CN104874014A - Preparation method of medical hemostatic occlusion dressing - Google Patents
Preparation method of medical hemostatic occlusion dressing Download PDFInfo
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- CN104874014A CN104874014A CN201510263377.0A CN201510263377A CN104874014A CN 104874014 A CN104874014 A CN 104874014A CN 201510263377 A CN201510263377 A CN 201510263377A CN 104874014 A CN104874014 A CN 104874014A
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Abstract
The invention discloses a preparation method of a medical hemostatic occlusion dressing. The preparation method comprises the following steps: (1), taking and pouring deionized water into a reactor, heating the reactor, slowly adding lemon peel pectin and gelatin, and mechanically stirring at the same time; (2), after the addition of the lemon peel pectin and gelatin, stirring continuously, then adding other components into the reactor, and carrying out mechanical stirring uniformly at the same time; (3), after the mixing of the materials, cooling hydrogel to be at a room temperature, so as to obtain the medical hemostatic occlusion dressing. The medical hemostatic occlusion dressing prepared through the method provided by the invention is high in bleeding stopping speed, has auxiliary functions of promoting wound surface healing, preventing adhesion and the like, is also better in biomechanics and air permeability, and has an important clinical application value; the preparation method provided by the invention has the advantages that the process is simple, requirements for equipment are relaxed, raw materials are low in cost and readily available, the cost is low, and industrialization is easy to realize.
Description
Technical field
The invention belongs to medical field of new, relate to a kind of preparation method of medical hemostatic shutoff dressing.
Technical background
Antibacterial anti hemorrhagic is the problem that hospital surgical often runs into always, is also the difficult problem that daily life often runs into.Medical dressing is a kind of medical supplies being used for covering the wounds such as burn, wound, ulcer, it is made temporarily to play the partial action of skin barrier function, an environment being conducive to wound healing is provided, waits for wound surface epithelization or be transitioned into and rebuild permanent skin barrier.Along with the physiopathologic further investigation to wound, people are also more and more deep to the understanding of wound, thus promoted updating and development of Wound dressing.Today, novel Wound dressing, relative to having there occurs revolutionary change in early days, from passive-type dressing, develops into coactive pattern dressing, then develops biological active dressing now.Desirable Wound dressing should meet following requirement: the loss of anti-sealing weight portion and body fluid; Resist bacterial invasion, protect from infection; There is affinity with wound surface, have good bonding force; Keep, promote granulation and epithelial tissue normal growth, promote recovery from illness; Preventing from scar, do not produce distortion; Softness, has certain mechanical strength; Ventilative, moisture-inhibiting, has moisture retention; Good biocompatibility; Comfortable, convenient, preparation is easily, cheap.The optimal method of flap coverage is self-skin transplant, but transplanting skin source is often not enough.Along with the development of Polymeric Industry, dressing prepared by synthetic material is also increasing.Between the nearly more than ten years, the research of dressing has had breakthrough progress, but still there is the poor biocompatibility with skin, be unfavorable for alleviating wound pain and promoting the defects such as wound healing, and dressing absorb wound fluid simultaneously and wound surface stick together, cause when removing and damage cambium, bring great misery to patient.Therefore how overcoming the deficiencies in the prior art is need the problem of solution at present badly.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, the preparation method of the medical hemostatic shutoff dressing that a kind of sealing characteristics that stops blooding is good is provided.
The object of the invention is to be achieved through the following technical solutions: a kind of preparation method of medical hemostatic shutoff dressing, this preparation method comprises the following steps: (1) is removed ionized water 20-30 weight portion and poured in reactor, reactor is heated to 76-85 DEG C, then in reactor, slowly add pectin from lemon peel 13-15 weight portion, gelatin 15-18 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 10-14 weight portion, Rhopilema esculenta collagen 3-6 weight portion, hyaluronate sodium 4-8 weight portion, starch 6-9 weight portion, Ammonium biphosphate 3-8 weight portion, Radix Glycyrrhizae extract 4-9 weight portion, Camellia oil 3-7 weight portion, nano zine oxide 4-9 weight portion and sodium alginate 2-5 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical hemostatic shutoff dressing.In step (1), mechanical agitation rotating speed is 30-60r/min.Described pectin from lemon peel molecular weight is 20-40kDa.Described gelatine molecular weight is 25-60kDa.
Described Radix Glycyrrhizae extract is filter through 80 eye mesh screens the powder obtained after Radix Glycyrrhizae powder comminution powder refines.
The present invention compared with prior art, tool has the following advantages and beneficial effect: the medical hemostatic shutoff dressing anthemorrhagic speed that (1) the inventive method obtains is fast, possesses wound healing, the ilities such as anti, also possess better biomechanical property and breathability, there is important clinical value; (2) preparation method technique of the present invention is simple, and do not have excessive demand to equipment, raw material valency is low to be easy to get, with low cost, is easy to realize industrialization.
Detailed description of the invention
embodiment 1
A kind of preparation method of medical hemostatic shutoff dressing, this preparation method comprises the following steps: (1) is removed ionized water 20 weight portion and poured in reactor, reactor is heated to 76-85 DEG C, then in reactor, slowly add pectin from lemon peel 13 weight portion, gelatin 15 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 10 weight portion, Rhopilema esculenta collagen 3 weight portion, hyaluronate sodium 4 weight portion, starch 6 weight portion, Ammonium biphosphate 3 weight portion, Radix Glycyrrhizae extract 4 weight portion, Camellia oil 3 weight portion, nano zine oxide 4 weight portion and sodium alginate 2 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical hemostatic shutoff dressing.In step (1), mechanical agitation rotating speed is 30-60r/min.Described pectin from lemon peel molecular weight is 20-40kDa.Described gelatine molecular weight is 25-60kDa.
Described Radix Glycyrrhizae extract is filter through 80 eye mesh screens the powder obtained after Radix Glycyrrhizae powder comminution powder refines.
embodiment 2
A kind of preparation method of medical hemostatic shutoff dressing, this preparation method comprises the following steps: (1) is removed ionized water 30 weight portion and poured in reactor, reactor is heated to 76-85 DEG C, then in reactor, slowly add pectin from lemon peel 15 weight portion, gelatin 18 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 14 weight portion, Rhopilema esculenta collagen 6 weight portion, hyaluronate sodium 8 weight portion, starch 9 weight portion, Ammonium biphosphate 8 weight portion, Radix Glycyrrhizae extract 9 weight portion, Camellia oil 7 weight portion, nano zine oxide 9 weight portion and sodium alginate 5 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical hemostatic shutoff dressing.In step (1), mechanical agitation rotating speed is 30-60r/min.Described pectin from lemon peel molecular weight is 20-40kDa.Described gelatine molecular weight is 25-60kDa.
Described Radix Glycyrrhizae extract is filter through 80 eye mesh screens the powder obtained after Radix Glycyrrhizae powder comminution powder refines.
embodiment 3
A kind of preparation method of medical hemostatic shutoff dressing, this preparation method comprises the following steps: (1) is removed ionized water 25 weight portion and poured in reactor, reactor is heated to 76-85 DEG C, then in reactor, slowly add pectin from lemon peel 14 weight portion, gelatin 16 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 12 weight portion, Rhopilema esculenta collagen 4 weight portion, hyaluronate sodium 6 weight portion, starch 7 weight portion, Ammonium biphosphate 6 weight portion, Radix Glycyrrhizae extract 6 weight portion, Camellia oil 5 weight portion, nano zine oxide 6 weight portion and sodium alginate 3 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical hemostatic shutoff dressing.In step (1), mechanical agitation rotating speed is 30-60r/min.Described pectin from lemon peel molecular weight is 20-40kDa.Described gelatine molecular weight is 25-60kDa.
Described Radix Glycyrrhizae extract is filter through 80 eye mesh screens the powder obtained after Radix Glycyrrhizae powder comminution powder refines.
Claims (5)
1. the preparation method of a medical hemostatic shutoff dressing, it is characterized in that this preparation method comprises the following steps: (1) is removed ionized water 20-30 weight portion and poured in reactor, reactor is heated to 76-85 DEG C, then in reactor, slowly add pectin from lemon peel 13-15 weight portion, gelatin 15-18 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 10-14 weight portion, Rhopilema esculenta collagen 3-6 weight portion, hyaluronate sodium 4-8 weight portion, starch 6-9 weight portion, Ammonium biphosphate 3-8 weight portion, Radix Glycyrrhizae extract 4-9 weight portion, Camellia oil 3-7 weight portion, nano zine oxide 4-9 weight portion and sodium alginate 2-5 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical hemostatic shutoff dressing.
2. the preparation method of a kind of medical hemostatic shutoff dressing according to claim 1, is characterized in that in step (1), mechanical agitation rotating speed is 30-60r/min.
3. the preparation method of a kind of medical hemostatic shutoff dressing according to claim 1, is characterized in that described pectin from lemon peel molecular weight is 20-40kDa.
4. the preparation method of a kind of medical hemostatic shutoff dressing according to claim 1, is characterized in that described gelatine molecular weight is 25-60kDa.
5. the preparation method of a kind of medical hemostatic shutoff dressing according to claim 1, is characterized in that described Radix Glycyrrhizae extract is filter through 80 eye mesh screens the powder obtained after Radix Glycyrrhizae powder comminution powder refines.
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| CN201510263377.0A CN104874014A (en) | 2015-05-22 | 2015-05-22 | Preparation method of medical hemostatic occlusion dressing |
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| CN201510263377.0A CN104874014A (en) | 2015-05-22 | 2015-05-22 | Preparation method of medical hemostatic occlusion dressing |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617448A (en) * | 2016-02-29 | 2016-06-01 | 苏州市贝克生物科技有限公司 | Fibrous protein compound hemostatic material and preparation method thereof |
| CN105617451A (en) * | 2016-02-29 | 2016-06-01 | 苏州市贝克生物科技有限公司 | Chitosan-based hemostatic material and preparation method thereof |
| CN105727355A (en) * | 2016-02-29 | 2016-07-06 | 苏州市贝克生物科技有限公司 | Air-permeable water-proof hemostatic thin film and preparation method thereof |
| CN105770970A (en) * | 2016-02-29 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Compound polysaccharide anti-hemorrhagic thin film and preparation method thereof |
| CN105854064A (en) * | 2016-03-28 | 2016-08-17 | 苏州蔻美新材料有限公司 | Breathable and hemostatic alginate dressing and preparation method thereof |
| CN106215230A (en) * | 2016-07-29 | 2016-12-14 | 江苏蓝湾生物科技有限公司 | A kind of preparation method of glass protecting wound surface gel |
| CN106512079A (en) * | 2016-11-28 | 2017-03-22 | 北京福爱乐科技发展有限公司 | Hemostasis spraying type adhesive and preparation method thereof |
| CN107754003A (en) * | 2017-10-19 | 2018-03-06 | 张永华 | A kind of method that bleeding-stopping dressing is prepared with hydrogel |
| CN108310449A (en) * | 2018-03-12 | 2018-07-24 | 常州市蒽盗钟情生物科技有限公司 | A kind of preparation method of gelfoam for hemostasis |
| CN109157670A (en) * | 2018-09-28 | 2019-01-08 | 常州大学 | A kind of composite antibacterial gel rubber material |
| CN110624103A (en) * | 2018-09-06 | 2019-12-31 | 美国海之萃生物科技有限公司 | Biomaterial device and topical composition for the treatment of skin disorders |
| EP3620152A1 (en) * | 2018-06-26 | 2020-03-11 | Marine Essence Biosciences Corporation of USA | Biomaterial devices and topical compositions for treatment of skin abnormalities |
| KR20200029362A (en) * | 2018-09-06 | 2020-03-18 | 미국 마린 에센스 바이오사이언시즈 코퍼레이션 | Biomaterial devices and topical compositions for guided tissue regeneration |
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Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617451A (en) * | 2016-02-29 | 2016-06-01 | 苏州市贝克生物科技有限公司 | Chitosan-based hemostatic material and preparation method thereof |
| CN105727355A (en) * | 2016-02-29 | 2016-07-06 | 苏州市贝克生物科技有限公司 | Air-permeable water-proof hemostatic thin film and preparation method thereof |
| CN105770970A (en) * | 2016-02-29 | 2016-07-20 | 苏州市贝克生物科技有限公司 | Compound polysaccharide anti-hemorrhagic thin film and preparation method thereof |
| CN105617448A (en) * | 2016-02-29 | 2016-06-01 | 苏州市贝克生物科技有限公司 | Fibrous protein compound hemostatic material and preparation method thereof |
| CN105854064A (en) * | 2016-03-28 | 2016-08-17 | 苏州蔻美新材料有限公司 | Breathable and hemostatic alginate dressing and preparation method thereof |
| CN106215230A (en) * | 2016-07-29 | 2016-12-14 | 江苏蓝湾生物科技有限公司 | A kind of preparation method of glass protecting wound surface gel |
| CN106512079B (en) * | 2016-11-28 | 2018-08-31 | 北京福爱乐科技发展有限公司 | A kind of hemostasis spary coating type adhesive and preparation method thereof |
| CN106512079A (en) * | 2016-11-28 | 2017-03-22 | 北京福爱乐科技发展有限公司 | Hemostasis spraying type adhesive and preparation method thereof |
| CN107754003A (en) * | 2017-10-19 | 2018-03-06 | 张永华 | A kind of method that bleeding-stopping dressing is prepared with hydrogel |
| CN108310449A (en) * | 2018-03-12 | 2018-07-24 | 常州市蒽盗钟情生物科技有限公司 | A kind of preparation method of gelfoam for hemostasis |
| EP3620152A1 (en) * | 2018-06-26 | 2020-03-11 | Marine Essence Biosciences Corporation of USA | Biomaterial devices and topical compositions for treatment of skin abnormalities |
| CN110624103A (en) * | 2018-09-06 | 2019-12-31 | 美国海之萃生物科技有限公司 | Biomaterial device and topical composition for the treatment of skin disorders |
| KR20200029363A (en) * | 2018-09-06 | 2020-03-18 | 미국 마린 에센스 바이오사이언시즈 코퍼레이션 | Biomaterial devices and topical compositions for treatment of skin abnormalities |
| KR20200029362A (en) * | 2018-09-06 | 2020-03-18 | 미국 마린 에센스 바이오사이언시즈 코퍼레이션 | Biomaterial devices and topical compositions for guided tissue regeneration |
| JP2020058785A (en) * | 2018-09-06 | 2020-04-16 | マリン エッセンス バイオサイエンシズ コーポレーション オブ ユーエスエーＭａｒｉｎｅ Ｅｓｓｅｎｃｅ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ ｏｆ ＵＳＡ | Biomaterial devices and topical compositions for treatment of skin abnormalities |
| KR102232371B1 (en) * | 2018-09-06 | 2021-03-30 | 미국 마린 에센스 바이오사이언시즈 코퍼레이션 | Biomaterial devices and topical compositions for treatment of skin abnormalities |
| KR102308773B1 (en) | 2018-09-06 | 2021-10-06 | 미국 마린 에센스 바이오사이언시즈 코퍼레이션 | Biomaterial devices and topical compositions for guided tissue regeneration |
| CN110624103B (en) * | 2018-09-06 | 2023-12-15 | 美国海之萃生物科技有限公司 | Biomaterial device and topical composition for the treatment of skin abnormalities |
| CN109157670A (en) * | 2018-09-28 | 2019-01-08 | 常州大学 | A kind of composite antibacterial gel rubber material |
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Application publication date: 20150902 |