CN105709261A - Preparation method of biological dressing for treating hemorrhoids - Google Patents

Preparation method of biological dressing for treating hemorrhoids Download PDF

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Publication number
CN105709261A
CN105709261A CN201610140654.3A CN201610140654A CN105709261A CN 105709261 A CN105709261 A CN 105709261A CN 201610140654 A CN201610140654 A CN 201610140654A CN 105709261 A CN105709261 A CN 105709261A
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China
Prior art keywords
preparation
biological dressing
alginate
powder
conducted
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Pending
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CN201610140654.3A
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Chinese (zh)
Inventor
李苏扬
李文遐
徐勤霞
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Suzhou Bec Biological Technology Co Ltd
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Suzhou Bec Biological Technology Co Ltd
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Priority to CN201610140654.3A priority Critical patent/CN105709261A/en
Publication of CN105709261A publication Critical patent/CN105709261A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a preparation method of a biological dressing for treating hemorrhoids. The method comprises the steps that the raw materials are weighed by weight and put into a reactor to be stirred to be uniform, and heating is conducted; the heated mixture is poured on a film making mold, screeding is conducted, thorough drying is conducted, demolding is conducted, and a drug storage layer is obtained; the obtained drug storage layer is composited with base cloth through a binder in a sticking mode, and a sticking composite material is punched by means of a dense acupuncture microporous machine; the punched dense composite material is cut into needed shapes, sealing and sterilizing are conducted, and the biological dressing is obtained. According to the biological dressing prepared through the method, the traditional Chinese medicine formula is adopted, irritation is small, no toxic or side effect exists, relapse is not prone to occur, the biological dressing has the advantages of being quick in effect, thorough in absorption, free of harm to mucous membrane, clean and sanitary, the drug action can be fully exerted, the duration of the action is long, and good curative effects on bleeding, swelling, pain, constipation and the like caused by external hemorrhoids are achieved.

Description

A kind of preparation method treating hemorrhoid biological dressing
Technical field
The invention belongs to medical bio field of new, relate to a kind of preparation method treating hemorrhoid biological dressing.
Technical background
In recent years, development along with society, the pressure of people is increasing, regular overtime work, causes that the time sat is oversize, add the change of dietary structure and dietary habit, the diet taste that height is warm, pungent, heavy wool becomes many people, and fat caused abdominal pressure increase, make the sickness rate of hemorrhoid substantially rise, in whole anorectal disease, the sickness rate of hemorrhoid accounts for 87.3%.Hemorrhoid are to be expanded, with venous plexus flexing under anal canal skin, the soft vein group formed by under human rectum's end mucosa.Hemorrhage, scratch where it itches, pain and to deviate from be four kinds of common clinical manifestation of hemorrhoid, hemorrhoid are also easy to other systemic diseases such as causing anal and intestinal disease, anemia, gynecological inflammation, anal eczema, vegetative nerve wadding disorderly simultaneously.Therefore hemorrhoid are treated timely, extremely important.
At present the Therapeutic Method of hemorrhoid there is operative therapy, medicine therapy for oral administration and medicine Topical therapy, operative therapy brings bigger misery to patient, complication is easily produced after being ill, and medicine therapy curative effect for oral administration is slow, the dosage form that medicine Topical therapy uses mostly is lotion, the time of washing is typically more of short duration, the time that medicament contacts with mucosa is little, medicine can not retain simultaneously, medicine can not be played a role fully, and curative effect is very micro-, zest is bigger, even a lot of people are for fast treating hemorrhoid, adopt injection for curing, but injection for curing can serve side effect by band, and often run hospital, cause inconvenience.
Biological dressing is the Novel wound reparation and protection material that grow up in repair in trauma " moistening healing " theoretical basis proposed such as Winter.Compared with traditional dressing, biological dressing has reduction and infects, improves wound healing quality, alleviate the misery of patient and facilitate the advantages such as medical personnel's operation, therefore obtains the favor of people.At present, dressing that is that China market has independent intellectual property right and that repair for hemorrhoid is also little, is almost blank.Therefore, study novel dressing and preparation method for treating hemorrhoid, be extremely important.
Summary of the invention
Present invention aims to the deficiencies in the prior art, it is provided that a kind of preparation method treating hemorrhoid biological dressing.
It is an object of the invention to be achieved through the following technical solutions: a kind of preparation method treating hemorrhoid biological dressing, this preparation method comprises the following steps: by weight, weigh hyaluronic acid 40-50 part, medical gelatin 10-20 part, alginate 6-12 part, Radix Sophorae Flavescentis powder 8-12 part, coltsfoot pollen 13-17 part, fig leaf powder 2-5 part, Fructus Cannabis powder 2-5 part, Stamen Nelumbinis powder 3-7 part, Herba Taraxaci powder 8-12 part, glycyrrhizic acid dipotassium 6-10 part, hyaluronate sodium 10-14 part, emulsifying agent 8-12 part and water 30-40 part are placed in after stirring in reactor, it is heated to 55 ~ 60 DEG C, heat time heating time is 20 ~ 25min；Mixture after heating is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Biological dressing prepared by the method by the present invention that the method have the advantages that adopts Chinese medicine formula, zest is little, have no side effect, not easily recur, have that disintegration rate is fast, rapid-action, absorb completely, do not hinder mucosa, the advantage of clean hygiene, good effect, it is possible to give full play to drug action, acting duration is long, and hemorrhage, swelling that external hemorrhoid is caused, pain, constipation etc. all have good curative effect.
Detailed description of the invention
Embodiment 1
A kind of preparation method treating hemorrhoid biological dressing, this preparation method comprises the following steps: by weight, weigh hyaluronic acid 40 parts, medical gelatin 10 parts, alginate 6 parts, Radix Sophorae Flavescentis powder 8 parts, coltsfoot pollen 13 parts, 2 parts of fig leaf powder, 2 parts of Fructus Cannabis powder, 3 parts of Stamen Nelumbinis powder, 8 parts of Herba Taraxaci powder, glycyrrhizic acid dipotassium 6 parts, hyaluronate sodium 10 parts, emulsifying agent 8 parts and 30 parts of water to be placed in after reactor stirs, being heated to 55 ~ 60 DEG C, heat time heating time is 20 ~ 25min；Mixture after heating is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Embodiment 2
A kind of preparation method treating hemorrhoid biological dressing, this preparation method comprises the following steps: by weight, weigh hyaluronic acid 50 parts, medical gelatin 20 parts, alginate 12 parts, Radix Sophorae Flavescentis powder 12 parts, coltsfoot pollen 17 parts, 5 parts of fig leaf powder, 5 parts of Fructus Cannabis powder, 7 parts of Stamen Nelumbinis powder, 12 parts of Herba Taraxaci powder, glycyrrhizic acid dipotassium 10 parts, hyaluronate sodium 14 parts, emulsifying agent 12 parts and 40 parts of water to be placed in after reactor stirs, being heated to 55 ~ 60 DEG C, heat time heating time is 20 ~ 25min；Mixture after heating is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Embodiment 3
A kind of preparation method treating hemorrhoid biological dressing, this preparation method comprises the following steps: by weight, weigh hyaluronic acid 45 parts, medical gelatin 15 parts, alginate 9 parts, Radix Sophorae Flavescentis powder 10 parts, coltsfoot pollen 15 parts, 3 parts of fig leaf powder, 3 parts of Fructus Cannabis powder, 5 parts of Stamen Nelumbinis powder, 10 parts of Herba Taraxaci powder, glycyrrhizic acid dipotassium 8 parts, hyaluronate sodium 10-14 part, emulsifying agent 9 parts and 35 parts of water to be placed in after reactor stirs, being heated to 55 ~ 60 DEG C, heat time heating time is 20 ~ 25min；Mixture after heating is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.

Claims (5)

1. the preparation method treating hemorrhoid biological dressing, it is characterized in that this preparation method comprises the following steps: by weight, weigh hyaluronic acid 40-50 part, medical gelatin 10-20 part, alginate 6-12 part, Radix Sophorae Flavescentis powder 8-12 part, coltsfoot pollen 13-17 part, fig leaf powder 2-5 part, Fructus Cannabis powder 2-5 part, Stamen Nelumbinis powder 3-7 part, Herba Taraxaci powder 8-12 part, glycyrrhizic acid dipotassium 6-10 part, hyaluronate sodium 10-14 part, emulsifying agent 8-12 part and water 30-40 part to be placed in after reactor stirs, being heated to 55 ~ 60 DEG C, heat time heating time is 20 ~ 25min；Mixture after heating is poured on masking mould, strikes off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
2. a kind of preparation method treating hemorrhoid biological dressing according to claim 1, it is characterised in that: described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
3. a kind of preparation method treating hemorrhoid biological dressing according to claim 1, it is characterised in that: described binding agent is pressure sensitive adhesive.
4. a kind of preparation method treating hemorrhoid biological dressing according to claim 1, it is characterised in that: described alginate is potassium alginate, sodium alginate or calcium alginate.
5. a kind of preparation method treating hemorrhoid biological dressing according to claim 1, it is characterised in that: described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
CN201610140654.3A 2016-03-14 2016-03-14 Preparation method of biological dressing for treating hemorrhoids Pending CN105709261A (en)

Priority Applications (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112057437A (en) * 2019-12-10 2020-12-11 江苏一全药业有限公司 Pharmaceutical preparation containing hyaluronic acid, pharmaceutical transdermal patch and preparation method thereof

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CN103463325A (en) * 2013-09-05 2013-12-25 刘风青 Traditional Chinese medicine preparation for treating haemorrhoids
CN104083591A (en) * 2014-07-27 2014-10-08 马磊 Externally-applied suppository for treating hemorrhoids and preparation method thereof
CN104324411A (en) * 2014-09-28 2015-02-04 张亚峰 Medical natural marine organism dressing

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112057437A (en) * 2019-12-10 2020-12-11 江苏一全药业有限公司 Pharmaceutical preparation containing hyaluronic acid, pharmaceutical transdermal patch and preparation method thereof
CN112057437B (en) * 2019-12-10 2021-08-06 江苏一全药业有限公司 Pharmaceutical preparation containing hyaluronic acid, pharmaceutical transdermal patch and preparation method thereof

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