CN104874009A - Method for preparing medical antibacterial gel material - Google Patents
Method for preparing medical antibacterial gel material Download PDFInfo
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- CN104874009A CN104874009A CN201510263409.7A CN201510263409A CN104874009A CN 104874009 A CN104874009 A CN 104874009A CN 201510263409 A CN201510263409 A CN 201510263409A CN 104874009 A CN104874009 A CN 104874009A
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- rubber material
- gel rubber
- medical antibacterial
- gel material
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Abstract
The invention discloses a method for preparing a medical antibacterial gel material. The method comprises the following steps: (1) taking beta-glucan by weight, dissolving beta-glucan in water, and stirring uniformly after beta-glucan is dissolved; (2) adding chitosan, nanometer titania and pseudo-ginseng powder into the beta-glucan aqueous solution and then fully stirring until the solution is uniform to obtain a gel material A; (3) taking and mixing alginic acid, polyethylene glycol, gelatin and water by weight, heating and stirring until the mixture is uniform to obtain a gel material B; (4) mixing the gel material A and the gel material B, and then adding hot water and stirring to obtain the medical antibacterial gel material. The medical antibacterial gel material prepared using the method provided by the invention is better in antibacterial effect and physical toughness, and is excellent in inhibiting effect on staphylococcus aureus and escherichia coli.
Description
Technical field
The invention belongs to medical field of new, relate to a kind of preparation method of medical antibacterial gel rubber material.
Technical background
Current treatment large-area burns, the most effective method of scald wound are epidermizations, adopt epidermization to treat wound and to protect.Adopt gel overlay should be good guard method, medical gel dressing materials should have following function: the loss preventing moisture and body fluid; Cover and protect wound surface not infected; Good biocompatibility; Ventilative, moisture retention is good; There is good bonding force with wound surface, do not produce distortion; There are enough mechanical strength sustenticular cell differentiation hypertrophy; Surface has enough cell adsorption abilities, and the firewood being conducive to cell echos growth; The normal growth of epithelial tissue and granulation can be promoted, promote wound healing, preventing from scar; Material source is sufficient, is easy to making, processing etc.In addition, medical gel material non-toxic, non-stimulated and without sensitization is also required.But the preparation process of existing gel is comparatively complicated, and technique controlling difficulty is higher, therefore needs a kind of preparation method comparatively simple, also there is the medical gel material of good antibacterial effect simultaneously.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, the preparation method of the medical antibacterial gel rubber material providing a kind of anti-microbial property good.
The object of the invention is to be achieved through the following technical solutions: a kind of preparation method of medical antibacterial gel rubber material, this preparation method comprises the following steps:
(1) get beta glucan 12-20 part by weight, with 10-14 part water dissolution, stir after dissolving;
(2) in the aqueous solution of beta glucan, adding chitosan 10-15 part, nano titanium oxide 1-3 part, Notoginseng Root 0.5-1.5 part, fully stir again, stir after adding, is gel rubber material A;
(3) separately get alginic acid 3-13 part, Polyethylene Glycol 4-12 part, gelatin 0.5-1.5 part, water 10-14 part by weight, heated and stirred, to evenly, is gel rubber material B;
(4) gel rubber material A and gel rubber material B is mixed, then add 30-40 DEG C of hot water 15-18 part and stirred 45min-90min, obtain medical antibacterial gel rubber material.Described polyvinyl alcohol molecule amount is 100-150kDa.Described alginic acid molecular weight is 20-100kDa.Described gelatine molecular weight is 25-60kDa.
In described step (3), heating-up temperature is 40-55 DEG C.
The present invention has following beneficial effect: the medical antibacterial gel rubber material prepared by method of the present invention achieves good effect on antibacterial and physical toughness, the material of preparation has extraordinary inhibitory action to staphylococcus aureus and escherichia coli, and by tests such as relevant ultrasonic impedances, sterilizing power, mucous membrane irritation, toxicity, rubber corrosiveness, show that product of the present invention meets relevant requirements involved by patent and standard.The hot strength of medical gel material of the present invention is also higher in addition, and the situation that gel rubber material can be avoided in use to occur to rupture occurs, and medical gel material of the present invention can not stick on wound face after a procedure in addition, reduces the healing difficulty of wound.The raw material of product of the present invention easily obtains simultaneously, and preparation method is simple, stop blooding, sterilize and promote that wound healing effect is positive among a small circle, and production cost is relatively low.
Detailed description of the invention
embodiment 1
A preparation method for medical antibacterial gel rubber material, this preparation method comprises the following steps:
(1) get beta glucan 12 parts by weight, with 10 parts of water dissolutioies, stir after dissolving;
(2) in the aqueous solution of beta glucan, adding chitosan 10 parts, nano titanium oxide 1 part, Notoginseng Root 0.5 part, fully stir again, stir after adding, is gel rubber material A;
(3) separately get alginic acid 3 parts, Polyethylene Glycol 4 parts, 0.5 part, gelatin, 10 parts, water by weight, heated and stirred, to evenly, is gel rubber material B;
(4) gel rubber material A and gel rubber material B is mixed, then add 30-40 DEG C of hot water 15 parts and stirred 45min-90min, obtain medical antibacterial gel rubber material.Described polyvinyl alcohol molecule amount is 100-150kDa.Described alginic acid molecular weight is 20-100kDa.Described gelatine molecular weight is 25-60kDa.
In described step (3), heating-up temperature is 40-55 DEG C.
embodiment 2
A preparation method for medical antibacterial gel rubber material, this preparation method comprises the following steps:
(1) get beta glucan 20 parts by weight, with 14 parts of water dissolutioies, stir after dissolving;
(2) in the aqueous solution of beta glucan, adding chitosan 15 parts, nano titanium oxide 3 parts, Notoginseng Root 1.5 parts, fully stir again, stir after adding, is gel rubber material A;
(3) separately get alginic acid 13 parts, Polyethylene Glycol 12 parts, 1.5 parts, gelatin, 14 parts, water by weight, heated and stirred, to evenly, is gel rubber material B;
(4) gel rubber material A and gel rubber material B is mixed, then add 30-40 DEG C of hot water 15-18 part and stirred 45min-90min, obtain medical antibacterial gel rubber material.Described polyvinyl alcohol molecule amount is 100-150kDa.Described alginic acid molecular weight is 20-100kDa.Described gelatine molecular weight is 25-60kDa.
In described step (3), heating-up temperature is 40-55 DEG C.
embodiment 3
A preparation method for medical antibacterial gel rubber material, this preparation method comprises the following steps:
(1) get beta glucan 16 parts by weight, with 12 parts of water dissolutioies, stir after dissolving;
(2) in the aqueous solution of beta glucan, adding chitosan 13 parts, nano titanium oxide 2 parts, Notoginseng Root 1 part, fully stir again, stir after adding, is gel rubber material A;
(3) separately get alginic acid 8 parts, Polyethylene Glycol 8 parts, 1 part, gelatin, 12 parts, water by weight, heated and stirred, to evenly, is gel rubber material B;
(4) gel rubber material A and gel rubber material B is mixed, then add 30-40 DEG C of hot water 17 parts and stirred 45min-90min, obtain medical antibacterial gel rubber material.Described polyvinyl alcohol molecule amount is 100-150kDa.Described alginic acid molecular weight is 20-100kDa.Described gelatine molecular weight is 25-60kDa.
In described step (3), heating-up temperature is 40-55 DEG C.
Claims (5)
1. a preparation method for medical antibacterial gel rubber material, is characterized in that this preparation method comprises the following steps:
(1) get beta glucan 12-20 part by weight, with 10-14 part water dissolution, stir after dissolving;
(2) in the aqueous solution of beta glucan, adding chitosan 10-15 part, nano titanium oxide 1-3 part, Notoginseng Root 0.5-1.5 part, fully stir again, stir after adding, is gel rubber material A;
(3) separately get alginic acid 3-13 part, Polyethylene Glycol 4-12 part, gelatin 0.5-1.5 part, water 10-14 part by weight, heated and stirred, to evenly, is gel rubber material B;
(4) gel rubber material A and gel rubber material B is mixed, then add 30-40 DEG C of hot water 15-18 part and stirred 45min-90min, obtain medical antibacterial gel rubber material.
2. the preparation method of a kind of medical antibacterial gel rubber material according to claim 1, is characterized in that described polyvinyl alcohol molecule amount is 100-150kDa.
3. the preparation method of a kind of medical antibacterial gel rubber material according to claim 1, is characterized in that described alginic acid molecular weight is 20-100kDa.
4. the preparation method of a kind of medical antibacterial gel rubber material according to claim 1, is characterized in that described gelatine molecular weight is 25-60kDa.
5. the preparation method of a kind of medical antibacterial gel rubber material according to claim 1, is characterized in that in described step (3), heating-up temperature is 40-55 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510263409.7A CN104874009A (en) | 2015-05-22 | 2015-05-22 | Method for preparing medical antibacterial gel material |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510263409.7A CN104874009A (en) | 2015-05-22 | 2015-05-22 | Method for preparing medical antibacterial gel material |
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| CN104874009A true CN104874009A (en) | 2015-09-02 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497087A (en) * | 2015-11-25 | 2016-04-20 | 牟杰 | Slow release gel loaded with sanqi and nanometer zinc oxide, preparing method thereof and applications of the slow-release gel |
| CN108066435A (en) * | 2018-01-30 | 2018-05-25 | 河南省商业科学研究所有限责任公司 | A kind of wound accelerator for concrescence containing persimmon leaf and wild jujube leaf extract |
| CN108939140A (en) * | 2018-08-14 | 2018-12-07 | 中山大学 | A kind of composition and medical hemostatic dressing for hemostasis |
| CN109157670A (en) * | 2018-09-28 | 2019-01-08 | 常州大学 | A kind of composite antibacterial gel rubber material |
| CN110038155A (en) * | 2019-04-11 | 2019-07-23 | 陕西仁浩医疗器械有限公司 | A kind of medical gel promoting wound healing |
| CN110075346A (en) * | 2019-04-30 | 2019-08-02 | 苏州卫生职业技术学院 | A kind of high-adhesiveness aerogel dressing and preparation method thereof |
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| EP0280737A1 (en) * | 1986-08-20 | 1988-09-07 | Teikoku Seiyaku Co., Ltd. | Steroidal drug-containing preparation for external use |
| CN101224310A (en) * | 2008-01-18 | 2008-07-23 | 中国人民解放军第四军医大学 | Medical wound dressing with anti-bacterial nanometer particulate |
| CN101664563A (en) * | 2009-09-21 | 2010-03-10 | 杭州国纳科技有限公司 | Preparation method of anti-bacterial hydrogel dressing |
| CN101897990A (en) * | 2010-07-06 | 2010-12-01 | 大连理工大学 | Dressing composition used for inhibiting scars and accelerating wound healing and application thereof |
| CN104043144A (en) * | 2014-07-03 | 2014-09-17 | 湖北科技学院 | Natural polysaccharide/nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing and radiation synthesis method thereof |
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2015
- 2015-05-22 CN CN201510263409.7A patent/CN104874009A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0280737A1 (en) * | 1986-08-20 | 1988-09-07 | Teikoku Seiyaku Co., Ltd. | Steroidal drug-containing preparation for external use |
| CN101224310A (en) * | 2008-01-18 | 2008-07-23 | 中国人民解放军第四军医大学 | Medical wound dressing with anti-bacterial nanometer particulate |
| CN101664563A (en) * | 2009-09-21 | 2010-03-10 | 杭州国纳科技有限公司 | Preparation method of anti-bacterial hydrogel dressing |
| CN101897990A (en) * | 2010-07-06 | 2010-12-01 | 大连理工大学 | Dressing composition used for inhibiting scars and accelerating wound healing and application thereof |
| CN104043144A (en) * | 2014-07-03 | 2014-09-17 | 湖北科技学院 | Natural polysaccharide/nano-TiO2 composite light-sensitive antimicrobial hydrogel dressing and radiation synthesis method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497087A (en) * | 2015-11-25 | 2016-04-20 | 牟杰 | Slow release gel loaded with sanqi and nanometer zinc oxide, preparing method thereof and applications of the slow-release gel |
| CN108066435A (en) * | 2018-01-30 | 2018-05-25 | 河南省商业科学研究所有限责任公司 | A kind of wound accelerator for concrescence containing persimmon leaf and wild jujube leaf extract |
| CN108939140A (en) * | 2018-08-14 | 2018-12-07 | 中山大学 | A kind of composition and medical hemostatic dressing for hemostasis |
| CN109157670A (en) * | 2018-09-28 | 2019-01-08 | 常州大学 | A kind of composite antibacterial gel rubber material |
| CN110038155A (en) * | 2019-04-11 | 2019-07-23 | 陕西仁浩医疗器械有限公司 | A kind of medical gel promoting wound healing |
| CN110075346A (en) * | 2019-04-30 | 2019-08-02 | 苏州卫生职业技术学院 | A kind of high-adhesiveness aerogel dressing and preparation method thereof |
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Application publication date: 20150902 |
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