CN105770975A - Preparation method of biological dressing capable of eliminating vitiligos - Google Patents

Preparation method of biological dressing capable of eliminating vitiligos Download PDF

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Publication number
CN105770975A
CN105770975A CN201610140652.4A CN201610140652A CN105770975A CN 105770975 A CN105770975 A CN 105770975A CN 201610140652 A CN201610140652 A CN 201610140652A CN 105770975 A CN105770975 A CN 105770975A
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CN
China
Prior art keywords
preparation
biological dressing
powder
parts
alginate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610140652.4A
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Chinese (zh)
Inventor
李苏扬
李文遐
徐勤霞
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Suzhou Bec Biological Technology Co Ltd
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Suzhou Bec Biological Technology Co Ltd
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Priority to CN201610140652.4A priority Critical patent/CN105770975A/en
Publication of CN105770975A publication Critical patent/CN105770975A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons

Abstract

The invention discloses a preparation method of a biological dressing capable of eliminating vitiligos. The preparation method comprises steps as follows: firstly, raw materials are weighed in parts by weight and put in a reactor for ultrasonic high-speed dispersion; secondly, the dispersed mixture is poured into a membrane production mold, strickled flat and fully dried, then demolding is performed, and a drug storing layer is prepared; thirdly, the prepared drug storing layer and a base fabric are bonded and compounded through a binder, and a dense microporous puncturing machine is used for puncturing the bonded composite; the punctured dense composite is cut into a required shape and sealed for sterilization. The effects of the components in the biological dressing prepared with the preparation method act cooperatively, so that proliferation of skin melanocytes and local immune adjustment can be effectively promoted, the effect of gradually eliminating skin vitiligos is achieved, and the biological dressing is non-toxic and has high biocompatibility; the biological dressing has the advantages of inhibiting growth of bacteria, promoting skin regeneration, accelerating healing and the like.

Description

A kind of preparation method eliminating white macula biological dressing
Technical field
The invention belongs to medical bio field of new, relate to a kind of preparation method eliminating white macula biological dressing.
Technical background
It is known that the skin often scar of empyrosis wound surface healing, often having cutaneous pigmentation or pigment obscission, As time goes on and gradually pigmentation would generally disappear, and the pigment white macula formed that comes off then is difficult to recover, until throughout one's life.In addition, due to tryrosinase hypofunction or disappearance in melanocyte, some constitutional vitiligo, the leukoplakia vulvaes causing the Progressive symmetric erythrokeratodermia that melanin generates to reduce or disappear and cause, bring great psychic trauma and life stress, even can make patient that future is lost confidence to patient.Everybody has a love of beauty, for most of women, is intended to change the appearance of oneself and has youth beautiful appearance.But current beauty industry is extremely complex, both advantageous and disadvantageous, many times, capital hears that some thus result in some cureless final results because of the former of cosmetics, for example with the mode playing hormone pin, patient body is had bigger side effect by this mode, it is easy to cause endocrine disturbance.And at present, the method commonly used in beauty industry includes therapeutic method of surgery, drug treatment and outer coating method.But operative treatment is not appropriate for for many patients, and risk is relatively larger；Pharmacotherapy, including oral medicine and medicine for external use, also ubiquity effect not significantly shortcoming.And owing to outer coating method is simple to operation, and the injury of patient is minimum, therefore, increasing consumer pays close attention to outer coating method.
Biological dressing is the Novel wound reparation and protection material that grow up in repair in trauma " moistening healing " theoretical basis proposed such as Winter.Compared with traditional dressing, biological dressing has reduction and infects, improves wound healing quality, alleviate the misery of patient and facilitate the advantages such as medical personnel's operation, therefore obtains the favor of people.But also little for the dressing of Firm speckle dispelling on the market at present, it is almost blank.In view of this, it is necessary to provide a kind of skin pigment that effectively can effectively solve to come off the dressing of white macula problem formed.
Summary of the invention
Present invention aims to the deficiencies in the prior art, it is provided that a kind of preparation method eliminating white macula biological dressing.
nullIt is an object of the invention to be achieved through the following technical solutions: a kind of preparation method eliminating white macula biological dressing，This preparation method comprises the following steps: by weight，Weigh hyaluronic acid 25-30 part、Collagen 20-25 part、Carbomer 10-14 part、Polyethylene Glycol 10-15 part、Sanguis Draxonis powder 10-15 part、Herba Taraxaci powder 2-5 part、Rhizoma Chuanxiong power 10-14 part、Alginate 6-12 part、Radix Salviae Miltiorrhizae powder 4-8 part、Helianthi powder 13-17 part、Rhizoma Belamcandae powder 3-6 part、Glycyrrhizic acid dipotassium 6-10 part、Emulsifying agent 3-10 part、Hyaluronate sodium 10-14 part and water 30-40 part are placed in reactor，Ultrasonic high speed dispersion，Ultrasonic frequency is 20-30KHz，Rate of dispersion 5000-5400r/min，Jitter time is 50-60min；Then the mixture after dispersion is poured on masking mould, strike off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
The method have the advantages that effect of each composition in biological dressing prepared by the present invention produces synergism, it is thus possible to effectively facilitate dermal melanin cell proliferation and Immunosuppressant therapy, reaching the effect of successive elimination leukoderma, nontoxic, biocompatibility is high；There is the advantages such as bacteria growing inhibiting, promotion skin regeneration, healing acceleration.
Detailed description of the invention
Embodiment 1
A kind of preparation method eliminating white macula biological dressing, this preparation method comprises the following steps: by weight, weigh hyaluronic acid 25 parts, collagen 20 parts, carbomer 10 parts, Polyethylene Glycol 10 parts, Sanguis Draxonis powder 10 parts, 2 parts of Herba Taraxaci powder, Rhizoma Chuanxiong power 10 parts, alginate 6 parts, Radix Salviae Miltiorrhizae powder 4 parts, 13 parts of Helianthi powder, 3 parts of Rhizoma Belamcandae powder, glycyrrhizic acid dipotassium 6 parts, emulsifying agent 3 parts, hyaluronate sodium 10 parts and 30 parts of water and be placed in reactor, ultrasonic high speed dispersion, ultrasonic frequency is 20-30KHz, rate of dispersion 5000-5400r/min, jitter time is 50-60min；Then the mixture after dispersion is poured on masking mould, strike off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Embodiment 2
A kind of preparation method eliminating white macula biological dressing, this preparation method comprises the following steps: by weight, weigh hyaluronic acid 30 parts, collagen 25 parts, carbomer 14 parts, Polyethylene Glycol 15 parts, Sanguis Draxonis powder 15 parts, 5 parts of Herba Taraxaci powder, Rhizoma Chuanxiong power 14 parts, alginate 12 parts, Radix Salviae Miltiorrhizae powder 8 parts, 17 parts of Helianthi powder, 6 parts of Rhizoma Belamcandae powder, glycyrrhizic acid dipotassium 10 parts, emulsifying agent 10 parts, hyaluronate sodium 14 parts and 40 parts of water are placed in reactor, ultrasonic high speed dispersion, ultrasonic frequency is 20-30KHz, rate of dispersion 5000-5400r/min, jitter time is 50-60min；Then the mixture after dispersion is poured on masking mould, strike off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
Embodiment 3
A kind of preparation method eliminating white macula biological dressing, this preparation method comprises the following steps: by weight, weigh hyaluronic acid 28 parts, collagen 23 parts, carbomer 12 parts, Polyethylene Glycol 13 parts, Sanguis Draxonis powder 13 parts, 3 parts of Herba Taraxaci powder, Rhizoma Chuanxiong power 12 parts, alginate 9 parts, Radix Salviae Miltiorrhizae powder 6 parts, 15 parts of Helianthi powder, 4 parts of Rhizoma Belamcandae powder, glycyrrhizic acid dipotassium 8 parts, emulsifying agent 6 parts, hyaluronate sodium 12 parts and 35 parts of water and be placed in reactor, ultrasonic high speed dispersion, ultrasonic frequency is 20-30KHz, rate of dispersion 5000-5400r/min, jitter time is 50-60min；Then the mixture after dispersion is poured on masking mould, strike off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
Described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
Described binding agent is pressure sensitive adhesive.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.

Claims (5)

1. the preparation method eliminating white macula biological dressing, it is characterized in that this preparation method comprises the following steps: by weight, weigh hyaluronic acid 25-30 part, collagen 20-25 part, carbomer 10-14 part, Polyethylene Glycol 10-15 part, Sanguis Draxonis powder 10-15 part, Herba Taraxaci powder 2-5 part, Rhizoma Chuanxiong power 10-14 part, alginate 6-12 part, Radix Salviae Miltiorrhizae powder 4-8 part, Helianthi powder 13-17 part, Rhizoma Belamcandae powder 3-6 part, glycyrrhizic acid dipotassium 6-10 part, emulsifying agent 3-10 part, hyaluronate sodium 10-14 part and water 30-40 part are placed in reactor, ultrasonic high speed dispersion, ultrasonic frequency is 20-30KHz, rate of dispersion 5000-5400r/min, jitter time is 50-60min；Then the mixture after dispersion is poured on masking mould, strike off, dry after fully, demoulding, prepare drug storing layer；Finally the drug storing layer prepared and base fabric are passed through the bonding compound of binding agent, utilize intensive acupuncture Micro hole machine to be punched by adhesive composite materials；Intensive composite after punching is cut into required form, seals sterilizing.
2. a kind of preparation method eliminating white macula biological dressing according to claim 1, it is characterised in that: described base cloth layer is non-woven fabrics or PU waterproof ventilated membrane.
3. a kind of preparation method eliminating white macula biological dressing according to claim 1, it is characterised in that: described binding agent is pressure sensitive adhesive.
4. a kind of preparation method eliminating white macula biological dressing according to claim 1, it is characterised in that: described alginate is potassium alginate, sodium alginate or calcium alginate.
5. a kind of preparation method eliminating white macula biological dressing according to claim 1, it is characterised in that: described emulsifying agent is stearic acid list glyceride or sodium lauryl sulphate.
CN201610140652.4A 2016-03-14 2016-03-14 Preparation method of biological dressing capable of eliminating vitiligos Pending CN105770975A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610140652.4A CN105770975A (en) 2016-03-14 2016-03-14 Preparation method of biological dressing capable of eliminating vitiligos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610140652.4A CN105770975A (en) 2016-03-14 2016-03-14 Preparation method of biological dressing capable of eliminating vitiligos

Publications (1)

Publication Number Publication Date
CN105770975A true CN105770975A (en) 2016-07-20

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Country Status (1)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1561959A (en) * 2004-04-09 2005-01-12 唐宝辉 Biological skin protective film
CN104324411A (en) * 2014-09-28 2015-02-04 张亚峰 Medical natural marine organism dressing
CN104368035A (en) * 2013-08-13 2015-02-25 凌峰 Biological dressing for eliminating white spots and scars on human body

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1561959A (en) * 2004-04-09 2005-01-12 唐宝辉 Biological skin protective film
CN104368035A (en) * 2013-08-13 2015-02-25 凌峰 Biological dressing for eliminating white spots and scars on human body
CN104324411A (en) * 2014-09-28 2015-02-04 张亚峰 Medical natural marine organism dressing

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
魏成广等: "《中国钾盐工业概览 第1版》", 31 July 2009, 上海交通大学出版社 *

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Application publication date: 20160720

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