CN104307029A - Medical natural biological dressing - Google Patents
Medical natural biological dressing Download PDFInfo
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- CN104307029A CN104307029A CN201410511405.1A CN201410511405A CN104307029A CN 104307029 A CN104307029 A CN 104307029A CN 201410511405 A CN201410511405 A CN 201410511405A CN 104307029 A CN104307029 A CN 104307029A
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Abstract
The invention discloses a medical natural biological dressing and a preparation method thereof. The medical natural biological dressing comprises a base fabric layer and an absorbing layer, wherein the base fabric layer is bonded to the absorbing layer through a binder, and the absorbing layer comprises the following raw materials in parts by weight: 10 to 40 parts of hydroxypropyl chitin, 10 to 40 parts of chitosan, 12 to 20 parts of chitosan lactate, 3 to 10 parts of pectin, 3 to 12 parts of alginate, 3-8 parts of inorganic nano-silver antibacterial agent, 3 to 8 parts of metronidazole, 5 to 20 parts of starch and 2 to 15 parts of plasticizer. The dressing provided by the invention is suitable for medical small-area hemostasis and bacteriostasis, promotion of wound healing and the like.
Description
Technical field
The present invention relates to a kind of medical dressing, be specifically related to a kind of medical natural biological dressing and preparation method thereof.
Background technology
Chitosan (CTS) is a kind of natural organic high-molecular polysaccharide deriving from shrimp, Carapax Eriocheir sinensis, there is good biocompatibility, have the biological function of cellulose in collagen and higher plant tissue in higher mammal tissue concurrently, to animal and plant, all there is good adaptability, be embodied on cellular level with the affine performance of organism, the probability producing antigen is very little.Have antiinflammatory, antibacterial, promote the biological activity such as wound repair, and play anastalsis by number of ways.
The bleeding-stopping dressing that current medical circle is commonly used mostly is cotton or gauze, although these hospital gauzes or cotton have good breathability, but itself there is no antibacterial, biocidal property, medicine must be coordinated carry out and treat or sterilize, and, traditional bleeding-stopping dressing run in the wild have people injured cause bleeding needs wrapping and process time, because rainy day or other environmental factors etc. extremely easily cause wound infection, and speed of wound healing is very slow.
In addition, natural marine organism class bleeding-stopping dressing ubiquity haemostatic effect commercially available is at present undesirable, and the problem such as the laminating degree difference of skin, therefore still await improving further its haemostatic effect and with the problem such as the stickiness of skin histology.
Summary of the invention
First object of the present invention is to provide a kind of medical natural biological dressing, and handbag draws together base cloth layer and absorbed layer, and base cloth layer is by binding agent and absorbed layer bonding.
Described absorbed layer comprises the raw material of following weight portion: Chitofilmer 10 ~ 40 parts, chitosan 10 ~ 40 parts, chitosan lactate 12 ~ 20 parts, pectin 3 ~ 10 parts, alginate 3 ~ 12 parts, nano silver inorganic antimicrobial agent 3 ~ 8 parts, metronidazole 3 ~ 8 parts, starch 5 ~ 20 parts, plasticizer 2 ~ 15 parts.
Described base cloth layer is non-woven fabrics, PU waterproof ventilated membrane or polyurethane film.
Described binding agent is pressure sensitive adhesive or PUR.
Described alginate is potassium alginate, sodium alginate or calcium alginate.
Described starch is corn starch or sweet potato starch.
Described plasticizer is glycerol, sorbitol, mannose or Polyethylene Glycol.
Second object of the present invention is to provide a kind of preparation method of medical natural biological dressing: take Chitofilmer, chitosan, chitosan lactate, alginate, nano silver inorganic antimicrobial agent, metronidazole, starch in proportion, be placed in reactor, add the acetic acid aqueous solution of 1.0% ~ 2.0%, be stirred to abundant dissolving; Add pectin and plasticizer, continue to stir and heated at constant temperature; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained absorbed layer; Absorbed layer and base cloth layer are passed through the bonding compound of binding agent; Air-dry 5 ~ 10 min of room temperature; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching cuts into required form, independent packaging after sterilization.
Described heated at constant temperature temperature is 50 ~ 70 DEG C, and heat time heating time is 10 ~ 20 min.
The micro-pore diameter on described adhesive composite materials surface is 2 ~ 4 mm, every 100 cm
2there are 80 ~ 120 micropores on adhesive composite materials surface.
The raw material of product of the present invention easily obtains, and preparation method is simple, stop blooding, sterilize and promote that wound healing effect is positive among a small circle, and production cost is relatively low.
detailed description of the invention:
Below in conjunction with concrete case study on implementation, the present invention is described in further detail:
Embodiment 1:
Take Chitofilmer 40 kg, chitosan 40 kg, chitosan lactate 20 kg, potassium alginate 12 kg, nano silver inorganic antimicrobial agent 8 kg, metronidazole 8 kg, corn starch 20 kg in proportion, be placed in reactor, add the acetic acid aqueous solution of 2.0%, be stirred to abundant dissolving; Add pectin 10 kg, sorbitol 15 kg, continue to stir and heated at constant temperature; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained absorbed layer; Absorbed layer and non-woven fabrics are passed through Performance of Pressure Sensitive Adhesive compound; Air-dry 10 min of room temperature; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching cuts into required form, independent packaging after sterilization.
Embodiment 2:
Take Chitofilmer 10 ~ 40 kg, chitosan 30 kg, chitosan lactate 18 kg, sodium alginate 10 kg, nano silver inorganic antimicrobial agent 5 kg, metronidazole 5 kg, corn starch 15 kg in proportion, be placed in reactor, add the acetic acid aqueous solution of 2.0%, be stirred to abundant dissolving; Add pectin 8 kg, mannose 12 kg, continue to stir and heated at constant temperature; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained absorbed layer; Absorbed layer and PU waterproof ventilated membrane are passed through Performance of Pressure Sensitive Adhesive compound; Air-dry 8 min of room temperature; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching cuts into required form, independent packaging after sterilization.
Embodiment 3:
Take Chitofilmer 10 kg, chitosan 10 kg, chitosan lactate 12 kg, calcium alginate 3 kg, nano silver inorganic antimicrobial agent 3 kg, metronidazole 3 kg, sweet potato starch 5 kg in proportion, be placed in reactor, add the acetic acid aqueous solution of 1.0%, be stirred to abundant dissolving; Add pectin 3 kg, mannose 2 kg, continue to stir and heated at constant temperature; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained absorbed layer; Absorbed layer and polyurethane film are passed through the bonding compound of PUR; Air-dry 5 min of room temperature; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching cuts into required form, independent packaging after sterilization.
Claims (9)
1. a medical natural biological dressing, it is characterized in that, comprise base cloth layer and absorbed layer, base cloth layer is by binding agent and absorbed layer bonding, and described absorbed layer comprises the raw material of following weight portion: Chitofilmer 10 ~ 40 parts, chitosan 10 ~ 40 parts, chitosan lactate 12 ~ 20 parts, pectin 3 ~ 10 parts, alginate 3 ~ 12 parts, nano silver inorganic antimicrobial agent 3 ~ 8 parts, metronidazole 3 ~ 8 parts, starch 5 ~ 20 parts, plasticizer 2 ~ 15 parts.
2. according to the medical natural biological dressing described in claim 1, it is characterized in that, described base cloth layer is non-woven fabrics, PU waterproof ventilated membrane or polyurethane film.
3. according to the medical natural biological dressing described in claim 2, it is characterized in that, described binding agent is pressure sensitive adhesive or PUR.
4. according to the medical natural biological dressing described in claim 3, it is characterized in that, described alginate is potassium alginate, sodium alginate or calcium alginate.
5. according to the medical natural biological dressing described in claim 4, it is characterized in that, described starch is corn starch or sweet potato starch.
6. according to the medical natural biological dressing described in claim 5, it is characterized in that, described plasticizer is glycerol, sorbitol, mannose or Polyethylene Glycol.
7. prepare the method for the medical natural biological dressing as described in claim 6 for one kind, it is characterized in that, take Chitofilmer, chitosan, chitosan lactate, alginate, nano silver inorganic antimicrobial agent, metronidazole, starch in proportion, be placed in reactor, add the acetic acid aqueous solution of 1.0% ~ 2.0%, be stirred to abundant dissolving; Add pectin and plasticizer, continue to stir and heated at constant temperature; This mixed solution is poured on masking mould, strikes off, after drying fully, demoulding, obtained absorbed layer; Absorbed layer and base cloth layer are passed through the bonding compound of binding agent; Air-dry 5 ~ 10 min of room temperature; Intensive acupuncture Micro hole machine is utilized to be punched by adhesive composite materials; Intensive composite after punching cuts into required form, independent packaging after sterilization.
8. according to the method for the medical natural biological dressing of the preparation described in claim 7, it is characterized in that, described heated at constant temperature temperature is 50 ~ 70 DEG C, and heat time heating time is 10 ~ 20 min.
9. the method for the medical natural biological dressing of preparation described according to Claim 8, it is characterized in that, the micro-pore diameter on described adhesive composite materials surface is 2 ~ 4 mm, every 100 cm
2there are 80 ~ 120 micropores on adhesive composite materials surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410511405.1A CN104307029A (en) | 2014-09-29 | 2014-09-29 | Medical natural biological dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410511405.1A CN104307029A (en) | 2014-09-29 | 2014-09-29 | Medical natural biological dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104307029A true CN104307029A (en) | 2015-01-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410511405.1A Pending CN104307029A (en) | 2014-09-29 | 2014-09-29 | Medical natural biological dressing |
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| CN (1) | CN104307029A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687087A (en) * | 2016-03-14 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Preparation method of skin-tightening and freckle-removing biological dressing |
| CN107653680A (en) * | 2017-08-31 | 2018-02-02 | 海宁文硕科技咨询有限公司 | A kind of antibacterial finishing process for fabric |
| CN110237295A (en) * | 2019-07-29 | 2019-09-17 | 河南亚都实业有限公司 | A kind of anthocyanidin alginate dressing |
| CN111529209A (en) * | 2020-05-07 | 2020-08-14 | 关怡 | Medical sanitary non-woven fabric |
Citations (7)
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| CN101664563A (en) * | 2009-09-21 | 2010-03-10 | 杭州国纳科技有限公司 | Preparation method of anti-bacterial hydrogel dressing |
| US20110218472A1 (en) * | 2010-03-02 | 2011-09-08 | Iran Polymer And Petrochemical Institute (Ippi) | Non drug based wound dressing polymer film and a method of producing the same |
| CN202366024U (en) * | 2011-11-15 | 2012-08-08 | 张剑钢 | Sterile plaster |
| CN103071181A (en) * | 2013-02-01 | 2013-05-01 | 刘昌桂 | Hydrogel as well as preparation method and purpose of hydrogel |
| CN103656731A (en) * | 2013-12-10 | 2014-03-26 | 徐广苓 | Medical chitosan dressing |
| CN103656730A (en) * | 2013-12-10 | 2014-03-26 | 徐花 | Medical chitosan dressing |
| CN103690989A (en) * | 2013-12-10 | 2014-04-02 | 徐广苓 | Medical chitosan haemostatic wound dressing |
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2014
- 2014-09-29 CN CN201410511405.1A patent/CN104307029A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664563A (en) * | 2009-09-21 | 2010-03-10 | 杭州国纳科技有限公司 | Preparation method of anti-bacterial hydrogel dressing |
| US20110218472A1 (en) * | 2010-03-02 | 2011-09-08 | Iran Polymer And Petrochemical Institute (Ippi) | Non drug based wound dressing polymer film and a method of producing the same |
| CN202366024U (en) * | 2011-11-15 | 2012-08-08 | 张剑钢 | Sterile plaster |
| CN103071181A (en) * | 2013-02-01 | 2013-05-01 | 刘昌桂 | Hydrogel as well as preparation method and purpose of hydrogel |
| CN103656731A (en) * | 2013-12-10 | 2014-03-26 | 徐广苓 | Medical chitosan dressing |
| CN103656730A (en) * | 2013-12-10 | 2014-03-26 | 徐花 | Medical chitosan dressing |
| CN103690989A (en) * | 2013-12-10 | 2014-04-02 | 徐广苓 | Medical chitosan haemostatic wound dressing |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687087A (en) * | 2016-03-14 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Preparation method of skin-tightening and freckle-removing biological dressing |
| CN107653680A (en) * | 2017-08-31 | 2018-02-02 | 海宁文硕科技咨询有限公司 | A kind of antibacterial finishing process for fabric |
| CN110237295A (en) * | 2019-07-29 | 2019-09-17 | 河南亚都实业有限公司 | A kind of anthocyanidin alginate dressing |
| CN111529209A (en) * | 2020-05-07 | 2020-08-14 | 关怡 | Medical sanitary non-woven fabric |
| CN111529209B (en) * | 2020-05-07 | 2021-03-02 | 济南瑞凝医药科技有限公司 | Medical sanitary non-woven fabric |
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| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20150128 |