CN102218157A - Preparation method of chitin functional hydrocolloid medical dressing - Google Patents
Preparation method of chitin functional hydrocolloid medical dressing Download PDFInfo
- Publication number
- CN102218157A CN102218157A CN2010101499606A CN201010149960A CN102218157A CN 102218157 A CN102218157 A CN 102218157A CN 2010101499606 A CN2010101499606 A CN 2010101499606A CN 201010149960 A CN201010149960 A CN 201010149960A CN 102218157 A CN102218157 A CN 102218157A
- Authority
- CN
- China
- Prior art keywords
- component
- chitin
- temperature
- preparation
- weight portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention provides a preparation method of chitin functional hydrocolloid medical dressing, comprising the following four steps of step 1: heating and dissolving 40 to 100 weight parts of medical polyisobutene hot-melt adhesives in a mixer under the temperature of 130 to 150 DEG C so as to form a component A; step 2: under the room temperature, mixing 20 to 40 weight parts of sodium carboxymethylcellulose, 0.5 to 5 weight parts of pectins and 5 to 30 weight parts of chitin or chitin deacetylation derivatives or chitosan to form a solid powder body, wherein the particle size of the powder body is 150 to 300 meshes; and the powder body is a component B; step 3: slowly adding the mixed component B into the component A; carrying out vacuum constant-temperature mixing for 60 to 90 minutes under the temperature of 120 to 130 DEG C; subsequently carrying out injection molding on a piece of release paper or a PU membrane; step 4: carrying out ageing treatment on formed hydrocolloid, subsequently forming shapes suitable for various wounds by extruding; and subsequently carrying out die-cutting and packaging to form a product, wherein the ageing treatment temperature is 30 to 65 DEG C; and the ageing treatment time is 72 hours. The dressing prepared by the preparation method is suitable for wounds with various shapes and is particularly suitable for the wounds at difficultly fixed parts.
Description
Technical field
The present invention relates to a kind of preparation method of hydrocolloid medical dressing, particularly a kind of preparation method of chitin activated water colloid medical dressing.
Background technology
The hydrocolloid medical dressing be a kind ofly have waterproof, anti, preserve moisture, the new pattern compress of advantage such as insulation.Used material and the effect difference of hydrocolloid medical dressing at present is very big, and the wound that bearing hydrocolloid dressing is nursed also is in different poses and with different expressions, at different wounds, needs safety good and have a hydrocolloid medical dressing of difference in functionality.
The patent of invention that relates to bearing hydrocolloid dressing from domestic patent retrieval to binomial, its publication number is respectively CN101569758A and CN101559236.The used main material of this binomial patent of invention bearing hydrocolloid dressing is adjuvants such as styrene, aliphatic petroleum resin, rubber, gelatin and sodium carboxymethyl cellulose, carboxymethyl chitosan, calcium alginate fibre, solid fine silver particle, preparation method complexity, safety remain to be proved.
Summary of the invention
The objective of the invention is in order to overcome the insecure defective of the complicated safety of existing bearing hydrocolloid dressing preparation method, invent a kind of polyisobutylene that adopts and make the preparation method that base material, chitin are made the chitin activated water colloid medical dressing of adjuvant.
The objective of the invention is to realize by following technical scheme:
The preparation method of described chitin activated water colloid medical dressing may further comprise the steps:
Step 1 is got 130 ℃ of-150 ℃ of dissolvings of heating of polyisobutylene medical hot melt glue 40-100 weight portion in blender, form the A component;
Step 2, at normal temperatures with sodium carboxymethyl cellulose 20-40 weight portion, pectin 0.5-5 weight portion and chitin or chitin deacetylase radical derivative or carapace polysaccharide 5-30 weight portion, be mixed into solid powder, diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and become product for being fit to the shape of various wounds then.
Good effect of the present invention is as follows: according to the chitin activated water colloid medical dressing of this method preparation, be applicable to the wound of different shape, be particularly suitable for the wound of difficult fixed position; The medical chitin bearing hydrocolloid dressing of the present invention, be composited by high molecular hydrophobic polyisobutylene adhesive and hydrophilic sodium carboxymethyl cellulose and chitin and pectin, double effects with bonding skin and absorption wound fluid, absorb transudate from wound surface, constitute moistening environment, be of value to the growth of cambium, promote wound healing.The medical chitin bearing hydrocolloid dressing of the present invention also has the effect of hemostasis, antiinflammatory, and effect is remarkable in the nursing of the part of wound formation initial stage and ulcer wound.
The polyisobutylene chemical property is stable, nontoxic, be applicable to medicine of different nature, do not change the character and the therapeutical effect of medicine, and weather-proof good, soft, the good springiness of polyisobutylene, hot strength are big, moulding processability is superior, and adhesion can be regulated, and is the desirable base material of bearing hydrocolloid dressing.Be added with the bearing hydrocolloid dressing of functional adjuvant sodium carboxymethyl cellulose, pectin and chitin, be applicable to that nursing ulcer is difficult for the wound of healing.Different wounds uses this bearing hydrocolloid dressing at different healing stages, can promote the healing of wound, reduces patient's misery.
The specific embodiment
One of embodiment:
Step 1 is got 75 kilograms in polyisobutylene medical hot melt glue, and heating up in de-airing mixer is heated to 130 ℃ of-150 ℃ of dissolvings, forms the A component;
Step 2 with 10 kilograms of 35 kilograms of sodium carboxymethyl cellulose, 4 kilograms of pectin and carapace polysaccharide, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4, with the hydrocolloid burin-in process of molding, the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and is become product for being fit to the shape of various wounds then.
Two of embodiment:
Step 1 is got 45 kilograms in polyisobutylene medical hot melt glue, and heating up in de-airing mixer is heated to 130 ℃ of-150 ℃ of dissolvings, forms the A component;
Step 2 with 5 kilograms of 25 kilograms of sodium carboxymethyl cellulose, 1 kilogram of pectin and chitins, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4, with the hydrocolloid burin-in process of molding, the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and is become product for being fit to the shape of various wounds then.
Three of embodiment:
Step 1 is got 95 kilograms in polyisobutylene medical hot melt glue, and heating up in de-airing mixer is heated to 130 ℃ of-150 ℃ of dissolvings, forms the A component;
Step 2 with 25 kilograms of 35 kilograms of sodium carboxymethyl cellulose, 5 kilograms of pectin and chitin deacetylase radical derivatives, is mixed into solid powder at normal temperatures, and diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4, with the hydrocolloid burin-in process of molding, the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and is become product for being fit to the shape of various wounds then.
The foregoing description is used for the present invention that explains, rather than limits the invention, and in the protection domain of spirit of the present invention and claim, any modification and change to the present invention makes all fall into protection scope of the present invention.
Claims (1)
1. the preparation method of a chitin activated water colloid medical dressing, it is characterized in that: the preparation method of described chitin activated water colloid medical dressing may further comprise the steps:
Step 1 is got 130 ℃ of-150 ℃ of dissolvings of heating of polyisobutylene medical hot melt glue 40-100 weight portion in blender, form the A component;
Step 2, at normal temperatures with sodium carboxymethyl cellulose 20-40 weight portion, pectin 0.5-5 weight portion and chitin or chitin deacetylase radical derivative or carapace polysaccharide 5-30 weight portion, be mixed into solid powder, diameter of particle is 150 orders-300 orders, and this powder body is the B component;
Step 3 slowly adds the A component with the B component that stirs, and carries out vacuum constant temperature and stirs, and temperature is 120 ℃-130 ℃, and the time is 60-90 minute, and injection mo(u)lding is on release paper or PU film then;
Step 4 is carried out burin-in process with the hydrocolloid of molding, and the burin-in process temperature is 30 ℃-65 ℃, and ageing treatment time is 72 hours, and compression molding is carried out the cross cutting packing again and become product for being fit to the shape of various wounds then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101499606A CN102218157A (en) | 2010-04-16 | 2010-04-16 | Preparation method of chitin functional hydrocolloid medical dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101499606A CN102218157A (en) | 2010-04-16 | 2010-04-16 | Preparation method of chitin functional hydrocolloid medical dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102218157A true CN102218157A (en) | 2011-10-19 |
Family
ID=44775024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101499606A Pending CN102218157A (en) | 2010-04-16 | 2010-04-16 | Preparation method of chitin functional hydrocolloid medical dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102218157A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716509A (en) * | 2012-06-25 | 2012-10-10 | 武汉纺织大学 | Antibacterial hydrocolloid and preparation method of antibacterial hydrocolloid |
| CN103028136A (en) * | 2012-12-14 | 2013-04-10 | 武汉奥绿新生物科技有限公司 | Hydrocolloid dressing and preparation method thereof |
| CN105797201A (en) * | 2016-03-11 | 2016-07-27 | 康迪菲（苏州）生物科技有限公司 | Composite hydrocolloid and preparation method thereof and hydrocolloid dressing and preparation method of hydrocolloid dressing |
| CN108578749A (en) * | 2018-07-11 | 2018-09-28 | 淮阴工学院 | A kind of medical compound pomelo-pectin sponge dressing and its preparation method and application of medicine-carried sustained release |
| CN109731122A (en) * | 2019-03-20 | 2019-05-10 | 安徽省康富医疗用品有限公司 | A kind of non-latex self-adhesive elastic bandage of hemostasis type and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2259464A (en) * | 1991-09-11 | 1993-03-17 | Robinson & Sons Ltd | Hydrocolloid dressing |
| US5534561A (en) * | 1993-06-01 | 1996-07-09 | Volke; Robert W. | Adhesives composition for a wound dressing |
| CN1268892A (en) * | 1997-08-29 | 2000-10-04 | 科洛普拉斯特公司 | Pressure sensitive adhesive composition |
| CN1679972A (en) * | 2005-02-02 | 2005-10-12 | 江汉大学 | Burn dressing of chitin gel with gradient structure and its preparation |
| CN101284145A (en) * | 2008-04-21 | 2008-10-15 | 武汉锐尔生物科技有限公司 | Medical dressing and its preparation method and application |
| CN101559236A (en) * | 2009-02-12 | 2009-10-21 | 泰州市三易医疗科技有限公司 | Silver-bearing hydrocolloid dressing and preparation method |
-
2010
- 2010-04-16 CN CN2010101499606A patent/CN102218157A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2259464A (en) * | 1991-09-11 | 1993-03-17 | Robinson & Sons Ltd | Hydrocolloid dressing |
| US5534561A (en) * | 1993-06-01 | 1996-07-09 | Volke; Robert W. | Adhesives composition for a wound dressing |
| CN1268892A (en) * | 1997-08-29 | 2000-10-04 | 科洛普拉斯特公司 | Pressure sensitive adhesive composition |
| CN1679972A (en) * | 2005-02-02 | 2005-10-12 | 江汉大学 | Burn dressing of chitin gel with gradient structure and its preparation |
| CN101284145A (en) * | 2008-04-21 | 2008-10-15 | 武汉锐尔生物科技有限公司 | Medical dressing and its preparation method and application |
| CN101559236A (en) * | 2009-02-12 | 2009-10-21 | 泰州市三易医疗科技有限公司 | Silver-bearing hydrocolloid dressing and preparation method |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716509A (en) * | 2012-06-25 | 2012-10-10 | 武汉纺织大学 | Antibacterial hydrocolloid and preparation method of antibacterial hydrocolloid |
| CN102716509B (en) * | 2012-06-25 | 2014-06-11 | 武汉纺织大学 | Antibacterial hydrocolloid and preparation method of antibacterial hydrocolloid |
| CN103028136A (en) * | 2012-12-14 | 2013-04-10 | 武汉奥绿新生物科技有限公司 | Hydrocolloid dressing and preparation method thereof |
| CN105797201A (en) * | 2016-03-11 | 2016-07-27 | 康迪菲（苏州）生物科技有限公司 | Composite hydrocolloid and preparation method thereof and hydrocolloid dressing and preparation method of hydrocolloid dressing |
| CN108578749A (en) * | 2018-07-11 | 2018-09-28 | 淮阴工学院 | A kind of medical compound pomelo-pectin sponge dressing and its preparation method and application of medicine-carried sustained release |
| CN109731122A (en) * | 2019-03-20 | 2019-05-10 | 安徽省康富医疗用品有限公司 | A kind of non-latex self-adhesive elastic bandage of hemostasis type and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102218157A (en) | Preparation method of chitin functional hydrocolloid medical dressing | |
| Ge et al. | Coordination of covalent cross-linked gelatin hydrogels via oxidized tannic acid and ferric ions with strong mechanical properties | |
| CN104324411A (en) | Medical natural marine organism dressing | |
| Cui et al. | Polysaccharide-based hydrogels for wound dressing: Design considerations and clinical applications | |
| CN101381906B (en) | Alginate nano Ag antibacterial fiber and method for making same | |
| CN104784741B (en) | chitosan functional hydrocolloid medical dressing | |
| CN103044700B (en) | Postoperative anti-adhesion membrane material and method for preparing same | |
| CN110917388A (en) | Injectable tissue adhesive hemostasis modified chitosan material, hydrogel thereof and preparation method thereof | |
| CN102908653A (en) | Preparation method of antiseptic dressing for deep infection wound | |
| CN103599558A (en) | Rapid hemostatic dressing and preparation method thereof | |
| CN102218156A (en) | Preparation method of alginate functional hydrocolloid medical dressing | |
| Wang et al. | Antibacterial porous sponge fabricated with capric acid-grafted chitosan and oxidized dextran as a novel hemostatic dressing | |
| CN105797201A (en) | Composite hydrocolloid and preparation method thereof and hydrocolloid dressing and preparation method of hydrocolloid dressing | |
| CN104307028A (en) | A medical natural-marine-organism bleeding-arresting dressing | |
| CN103007339A (en) | Biological powder medical dressing and preparation method thereof | |
| CN112717194A (en) | Degradable chitosan-based composite hemostatic film | |
| CN104874008A (en) | Method for preparing medical bio-antimicrobial dressing | |
| Bahú et al. | Plant polysaccharides in engineered pharmaceutical gels | |
| CN104208743A (en) | Bleeding-stopping pain-relieving dressing | |
| CN105727347A (en) | Composite hemostatic sponge and preparation method thereof | |
| CN102218155A (en) | Preparation method for nano-silver functional hydrocolloid medical dressing | |
| CN104307029A (en) | Medical natural biological dressing | |
| CN110124082A (en) | Swelling type medical bio gel filler based on Polysaccharide from Portulaca oleracea and chromocor extract | |
| CN101229146B (en) | Chitosan and polyvinyl alcohol compound cataplasm matrix and preparing method thereof | |
| CN106620834A (en) | Styptic powder dressing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20111019 |