CN104906623B - A kind of cellulose-based dressings and its preparation method and application - Google Patents
A kind of cellulose-based dressings and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of cellulose-based dressings, its preparation method comprises the following steps：1) cellulose solvent is cooled to 12~5 DEG C in advance, cellulose is then added, stirring and dissolving carries out deaeration, removal of impurities, obtains cellulose solution；2) cellulose solution is poured over glass plate one end, it is solidified in solidify liquid using the tape casting, obtain porous cellulose membrane；3) using step 2) made from cellulose membrane as the permeable membrane in osmosis device, and prepare surface modification solution, it is dynamically passed through cellulose membrane through cellulose fenestra, be finally washed with water, dry, obtain described cellulose-based dressings.Preparation method of the present invention is simple, with low cost, green non-poisonous, reproducible；The cellulose-based dressings of preparation had both possessed uniform pore structure, excellent intensity and toughness, had high transparency again and absorbed the ability of diffusate；And haemostatic effect is good, can remarkably promote wound healing, using safety, is expected to clinically promote the use of.
Description
Technical field
The invention belongs to Functional polymer materials technology field, and in particular to a kind of cellulose-based dressings and preparation method thereof
And application.
Background technology
Medical dressing in wound healing process, can substitute impaired skin and play temporarily as the covering of wound
The barrier action of when property, it is to avoid or there is provided the environment for being conducive to wound healing for control wound infection.With the aging of population and slow
Property exedens wound increases, and the market value of medical dressing also becomes more and more important.The second half in 19th century, surgeon
Gamgee has invented the Gamgee dressing with water imbibition and antibiotic property, i.e. cotton pad.From British scientist George in 1962
Doctor Winter has found that wet environment is conducive to wound healing, since proposing " wet wound healing is theoretical " so that people are to wound
The understanding of mouthful agglutination has breakthrough progress, and various new-type dressing have obtained broad development, occur in that film, foam,
The a series of new dressing such as aerogel dressing.And in China at present, surgical wound is still generally applied using the tradition such as gauze is single
Material.Improved with the improvement of people's life quality, surgical patients are also corresponding to the requirement such as wound healing, comfort level, therefore obtain one
Planting is conducive to wound healing and the dressing of rehabilitation to have become one of the problem of current scientific worker pays close attention to.Numerous studies
Show, film class compounded dressing for wound can keep wound wet union environment, it is thin with biocompatibility, antibiotic property, barrier
The invasion of the microorganisms such as bacterium, allow oxygen by and promote the characteristic such as wound healing, its technology of preparing is also increasingly by people
Concern.
Cellulose and its derivates play very important work as the existing considerably long history of membrane material in film industry
With " particularly recent years, various performance function cellulose films emerge in an endless stream, and are one researched and developed in Cellulose Science
Individual focus ".Cellulose is as a kind of inexhaustible renewable raw materials, in film industry, with synthetic polymer
The irreplaceable advantage of film:Stable chemical performance；Safety, good biocompatibility；Cost is low；Still there is high intensity under hygrometric state；Into
Film mechanical strength is good, and thin film fabrication is easy；Easily controllable aperture and porosity.There is potential Development volue.But, due to fibre
The plain structure and characteristic of itself of dimension, the exploitation of cellulose membrane show the feature different from other films.Cellulose is nature
The preferable two kinds of natural macromolecular materials of biodegradable in boundary, biocompatibility.Cellulose contains great amount of hydroxy group, is easily formed and divided
Sub interior and intermolecular hydrogen bonding, with certain mechanical strength.Native cellulose molecule and its derivative, are pharmaceutically widely used in increasing
The purposes such as thick, figuration, slow-release controlled-release, film forming.Due to its raw material extensively, the compatibility with human body, environment is good, obtains people pole
Big concern.
Wound healing process is a complicated process, and the different wounds stage different with same wound has to dressing
Different requirements.Any one homogenous material can not all meet the complicated needs of wound healing process at present, and natural material is made
The most of absorbability of dressing it is good, with good biocompatibility and biological activity, but bad mechanical property.Synthesize high score
Sub- material isolation performance is good, and mechanical strength is good, but absorbent properties are poorer with respect to natural material.Can be by answering material
Close, have the advantage of multiple material concurrently, realize the requirement of wound healing.Such as it is used in combination with hydrogel and built up membrane or foam,
Drug dressing can also be obtained by either physically or chemically introducing medicine in dressing, they can be same in the protection surface of a wound
When can play a part of treat wound again.Prepolymer method, completion method, infusion process can be used at present by the thing with specific function
Matter is loaded in dressing carrier, prepares composite multi-functional dressing.But these preparation methods are there is also some problems, such as some bases
Material does not possess natural pore structure, and preparing pore structure needs to add pore-foaming agent, and the later stage may need to remove pore-foaming agent, and technique is relatively multiple
It is miscellaneous；Selection of the simple Liquid-liquid mixing film method to functional mass has certain limitation；Film immersion method is likely to result in table
Face functional mass is uneven etc. in film internal coat.
The content of the invention
It is an object of the invention to provide a kind of cellulose-based dressings and its preparation method and application, the preparation method is simple
Easy, nontoxic pollution-free is reproducible, and obtained cellulose-based dressings intensity is high, good permeability, can effectively facilitate wound and be cured
Close, be adapted to popularization and application.
To achieve the above object, the technical solution adopted by the present invention is：A kind of preparation method of cellulose-based dressings, including
Following steps：
1) cellulose solvent is cooled to -12~-5 DEG C in advance, cellulose (natural polymer cellulose) is then added, stirred molten
Solution, carries out deaeration, removal of impurities, obtains cellulose solution；
2) by step 1) made from cellulose solution be poured over glass plate one end, using the tape casting consolidate in solidify liquid it
Change, obtain porous cellulose membrane；
3) using step 2) made from cellulose membrane as the permeable membrane in osmosis device, and prepare surface modification solution,
Surface modification solution is dynamically passed through cellulose membrane by the hole of cellulose membrane using osmosis method, be finally washed with water, do
It is dry, obtain described cellulose-based dressings.
In such scheme, the cellulose solvent is alkali/aqueous solution of urea or alkali/thiourea solution.
It is preferred that, the cellulose solvent is NaOH/ aqueous solution of urea or NaOH/ thiourea solutions.
It is preferred that, in the cellulose solvent, the mass concentration of sodium hydroxide is 6~10%, the quality of urea or thiocarbamide
Concentration is 2~20%.
It is preferred that, the mass concentration of cellulose is 0.5~15% in gained cellulose solution.
In such scheme, the solidify liquid is water or dilute acid solution.
In such scheme, the osmosis method is, using suction filtration, ultrafiltration or pressuring method, to pass through surface modification solution
The hole of cellulose membrane dynamically passes through cellulose membrane.
In such scheme, the surface modification solution is natural polymer solution, the synthesized polymer of natural polymer formation
Thing solution or drug solution.
In such scheme, the natural polymer is water-soluble chitosan, carboxymethyl chitin, chitosan or carboxymethyl shell
Glycan etc.；The synthetic polymer is polyvinyl alcohol, PVP or PEO；The medicine is antibacterial
Medicine, analgesics anti-inflammatory or the medicine for promoting wound healing.
In such scheme, the medicine be antimicrobial, analgesics anti-inflammatory and promote wound healing medicine in one kind or
It is a variety of to mix in any proportion.
It is preferred that, the choice of drug antimicrobial (such as tetracycline, hydroxy tetracycline and gentamicin), analgesics anti-inflammatory
(such as naproxen sodium salt and aspirin) and/or the medicine (such as Yunnan Baiyao) for promoting wound healing.
In such scheme, the mass concentration 0.005 of natural polymer or synthetic polymer in the surface modification solution~
30%, the mass concentration of medicine is 0.005~5% in drug solution.
In such scheme, medicine and/or nano-particle are also contained in described cellulose-based dressings.
In such scheme, the medicine be antimicrobial, analgesics anti-inflammatory and promote wound healing medicine in one kind or
It is a variety of to mix in any proportion.
It is preferred that, the choice of drug antimicrobial (such as tetracycline, hydroxy tetracycline and gentamicin), analgesics anti-inflammatory
(such as naproxen sodium salt and aspirin) and/or the medicine (such as Yunnan Baiyao) for promoting wound healing, described medicine is excellent
It is 0.005~5% to select mass content.Wherein, cellulose-based dressings drug content refers to the medicine that cellulose-based dressings are soaked
The concentration of drug in solution.
In such scheme, the nano-particle is with one kind in anti-microbial property, the nano-particle of promotion wound healing
Or a variety of mix in any proportion.
It is preferred that, the nano-particle is magnetic ferric oxide nanoparticles, titanium dioxide nano-particle, zinc oxide nano
One or more in rice corpuscles, Nano silver grain etc..
In such scheme, step 2) or step 3) described in cellulose membrane can be replaced marketed cellulose film, paper, gauze
Or cotton.
Cellulose-based dressings can be applied to biomedicine field according to made from such scheme.
Beneficial effects of the present invention are：
1) matrix material (cellulose membrane) of dressing of the present invention, compound species, compound quantity are controllable, substantially increase
Its application.
2) present invention is dissolved in cellulose solvent and prepares fibre using the natural polymer cellulose of abundance as raw material
The plain solution of dimension, then using osmosis method to prepare cellulose-based dressings, the preparation method being related to is simple and easy to apply, nontoxic without dirt
Dye, it is reproducible, and any chemical adhesive, initiator and pore-foaming agent need not be added, it is physical process, chemistry does not occur
Reaction, it is environment-friendly.
3) dressing prepared by this method has good biocompatibility and biological activity, and it is strong to possess higher stretching
Degree, with loose structure, gas permeability, moisture retention are good, will not adhesion wound, epithelial cell growth can be accelerated, accelerate new micro- blood
Pipe regenerates, and resists bacterial invasion, prevents wound infection, can also load various medicines, promotes wound tissue's healing, is further to face
Bed application is laid a good foundation.
Brief description of the drawings
Fig. 1 be embodiment 1 obtained by cellulose-based dressings undried state shape appearance figure.
Fig. 2 be embodiment 2 obtained by cellulose-based dressings undried state shape appearance figure.
Fig. 3 be embodiment 3 obtained by cellulose-based dressings ESEM (SEM) figure.
Fig. 4 is the cellulose-based dressings and the swelling behavior figure of pure cellulose film obtained by embodiment 3.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments and accompanying drawing, it is right
The present invention is further elaborated.It should be appreciated that specific embodiment described herein is only to explain the present invention, not
For limiting the present invention.
In following examples, unless specific instructions, the reagent of use is commercially available chemical reagent or industrial products.
The cellulose is natural polymer cellulose.
Embodiment 1
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by NaOH/ aqueous solution of urea (sodium hydroxide, urea, water mass ratio be 7:12:81) -12 DEG C of conducts are pre-chilled to
Cellulose solvent dissolves cellulose and carries out deaeration, removal of impurities, obtains the cellulose solution that cellulose mass concentration is 4%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 3% chitosan solution (surface modification solution), by step 2) made from porous fibre
Plain film makes hole dynamic of the 2ml chitosan solutions by cellulose membrane as the permeable membrane in osmosis device using ultrafiltration
Through cellulose membrane, finally with being dried after distillation water washing, described cellulose-based dressings are obtained.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 2
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by NaOH/ aqueous solution of urea (sodium hydroxide, urea, water mass ratio be 7:12:81) -12 DEG C of conducts are pre-chilled to
Cellulose solvent dissolves cellulose and carries out deaeration, removal of impurities, obtains the cellulose solution that cellulose mass concentration is 4%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 1% chitosan solution (surface modification solution), by step 2) made from porous fibre
Plain film makes hole dynamic of the 10ml chitosan solutions by cellulose membrane as the permeable membrane in osmosis device using suction method
Through cellulose membrane, finally with being dried after distillation water washing, described cellulose-based dressings are obtained.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 3
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by NaOH/ aqueous solution of urea (sodium hydroxide, urea, water mass ratio be 7:12:81) -12 DEG C of conducts are pre-chilled to
Cellulose solvent dissolves cellulose and carries out deaeration, removal of impurities, obtains the cellulose solution that cellulose mass concentration is 4%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 3% chitosan solution (surface modification solution), by step 2) made from perforated membrane make
For the permeable membrane in osmosis device, hole of the 10ml chitosan solutions through cellulose membrane is set dynamically to pass through fiber using ultrafiltration
Plain film, finally with being dried after distillation water washing, obtains described cellulose-based dressings.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 4
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by NaOH/ thiourea solutions (sodium hydroxide, thiocarbamide, water mass ratio be 9.5:4.5:86) -5 DEG C of works are pre-chilled to
Cellulose is dissolved for cellulose solvent and deaeration, removal of impurities is carried out, and obtains the cellulose solution that cellulose mass concentration is 5%；
2) by step 1) made from cellulose solution be poured over glass plate one end, preparation mass concentration is 9% sulfuric acid solution
As solidify liquid, the tape casting is used cellulose solution is solidified into porous cellulose film of the thickness for 0.30mm in solidify liquid；
3) prepare mass concentration be 5% chitosan solution (surface modification solution), by step 2) made from porous fibre
Plain film makes hole dynamic of the 20ml chitosan solutions by cellulose membrane as the permeable membrane in osmosis device using ultrafiltration
Through cellulose membrane, finally with being dried after distillation water washing, described cellulose-based dressings are obtained.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 5
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by NaOH/ aqueous solution of urea (sodium hydroxide, urea, water mass ratio be 7:12:81) -12 DEG C of conducts are pre-chilled to
Cellulose solvent dissolves cellulose and carries out deaeration, removal of impurities, obtains the cellulose solution that cellulose mass concentration is 15%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 1% chitosan solution (surface modification solution), by step 2) made from porous fibre
Plain film makes hole of the 20ml chitosan solutions through cellulose membrane dynamically saturating as the permeable membrane in osmosis device using ultrafiltration
Cellulose membrane is crossed, finally with being dried after distillation water washing, described cellulose-based dressings are obtained.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 6
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by NaOH/ aqueous solution of urea (sodium hydroxide, urea, water mass ratio be 7:12:81) -12 DEG C of conducts are pre-chilled to
Cellulose solvent dissolves cellulose and carries out deaeration, removal of impurities, obtains the cellulose solution that cellulose mass concentration is 9%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 1% chitosan solution (surface modification solution), by step 2) made from porous fibre
Plain film makes hole dynamic of the 20ml chitosan solutions by cellulose membrane as the permeable membrane in osmosis device using ultrafiltration
Through cellulose membrane, finally with being dried after distillation water washing, described cellulose-based dressings are obtained.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 7
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by NaOH/ aqueous solution of urea (sodium hydroxide, urea, water mass ratio be 10:9:81) -12 DEG C of conducts are pre-chilled to
Cellulose solvent dissolves cellulose and carries out deaeration, removal of impurities, obtains the cellulose solution that cellulose mass concentration is 0.5%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 1% chitosan solution (surface modification solution), by step 2) made from porous fibre
Plain film makes hole dynamic of the 20ml chitosan solutions by cellulose membrane as the permeable membrane in osmosis device using ultrafiltration
Through cellulose membrane, finally with being dried after distillation water washing, described cellulose-based dressings are obtained.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 8
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) NaOH/ aqueous solution of urea (sodium hydroxide, the urine of 0.421g magnetic ferric oxide nanoparticles will be added
Element, the mass ratio of the aqueous solution are 7:12:81) -12 DEG C are pre-chilled to dissolve cellulose as cellulose solvent and carry out deaeration, remove
It is miscellaneous, obtain the cellulose solution that cellulose mass concentration is 4%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 15% chitosan solution (surface modification solution), by step 2) made from porous fibre
Plain film makes hole dynamic of the 20ml chitosan solutions by cellulose membrane as the permeable membrane in osmosis device using ultrafiltration
Through cellulose membrane, finally with being dried after distillation water washing, described cellulose-based dressings are obtained.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 9
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by add 0.889g magnetic ferric oxide nanoparticles NaOH/ aqueous solution of urea (sodium hydroxide, urea,
The mass ratio of water is 7:12:81) -12 DEG C are pre-chilled to dissolve cellulose as cellulose solvent and carry out deaeration, removal of impurities, fiber is obtained
Plain mass concentration is 4% cellulose solution；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 25% chitosan solution (surface modification solution), by step 2) made from porous fibre
Plain film makes hole dynamic of the 20ml chitosan solutions by cellulose membrane as the permeable membrane in osmosis device using ultrafiltration
Through cellulose membrane, finally with being dried after distillation water washing, described cellulose-based dressings are obtained.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 10
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) will add 0.889g load Nano silver grain nano titanium oxide NaOH/ aqueous solution of urea (sodium hydroxide,
Urea, the mass ratio of water are 7:12:81) -12 DEG C are pre-chilled to dissolve cellulose as cellulose solvent and carry out deaeration, removal of impurities,
Obtain the cellulose solution that cellulose mass concentration is 4%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 15% chitosan solution (surface modification solution), by step 2) made from porous fibre
Plain film makes hole dynamic of the 20ml chitosan solutions by cellulose membrane as the permeable membrane in osmosis device using suction method
Through cellulose membrane, finally with being dried after distillation water washing, described cellulose-based dressings are obtained.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 11
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by NaOH/ aqueous solution of urea (sodium hydroxide, urea, water mass ratio be 7:12:81) -12 DEG C of conducts are pre-chilled to
Cellulose solvent dissolves cellulose and carries out deaeration, removal of impurities, obtains the cellulose solution that cellulose mass concentration is 4%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 3% poly-vinyl alcohol solution (surface modification solution), by step 2) made from perforated membrane
As the permeable membrane in osmosis device, 10ml chitosan solutions are made dynamically to be passed through by the hole of cellulose membrane using ultrafiltration
Cellulose membrane, finally with being dried after distillation water washing, obtains described cellulose-based dressings.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 12
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
1) by NaOH/ aqueous solution of urea (sodium hydroxide, urea, water mass ratio be 7:12:81) -12 DEG C of conducts are pre-chilled to
Cellulose solvent dissolves cellulose and carries out deaeration, removal of impurities, obtains the cellulose solution that cellulose mass concentration is 4%；
2) by step 1) made from cellulose solution be poured over glass plate one end, prepare mass concentration molten for 5% sulfuric acid
Liquid uses the tape casting cellulose solution is solidified into porous cellulose of the thickness for 0.25mm in solidify liquid as solidify liquid
Film；
3) prepare mass concentration be 0.5% tetracycline (surface modification solution), by step 2) made from perforated membrane
As the permeable membrane in osmosis device, 10ml chitosan solutions are made dynamically to be passed through by the hole of cellulose membrane using ultrafiltration
Cellulose membrane, finally with being dried after distillation water washing, obtains described cellulose-based dressings.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Embodiment 13
A kind of preparation method of cellulose-based dressings, is comprised the following steps that：
The chitosan solution that mass concentration is 20wt% is prepared, cotton is as the permeable membrane in osmosis device, using taking out
The mode of filter makes 50ml chitosan solutions pass through cotton, finally with being dried after distillation water washing, obtains described cellulose-based dressings.
Cellulose-based dressings made from the present embodiment can substitute impaired skin and play temporary barrier action, it is to avoid or
Controlling wound infection, there is provided the environment for being conducive to wound healing.
Fig. 1,2 are respectively that embodiment 1 and embodiment 2 are made in shape appearance figure of the cellulose-based dressings in undried state, figure
Show that obtained cellulose-based dressings color is homogeneous, illustrate that chitosan is uniformly adhered to cellulose membrane surface；Fig. 3 is embodiment
3 are made ESEM (SEM) figure of cellulose-based dressings, it can be seen that micro-nano is presented in cellulose-based dressings produced by the present invention
The pore structure of rice, illustrates that the introducing of chitosan does not change compatible between the natural pore structure of cellulose membrane, the material of composite membrane two
Property is good；Fig. 4 is the swelling behavior figure that cellulose-based dressings and pure cellulose film is made in embodiment 3, from fig. 4, it can be seen that this
The obtained cellulose-based dressings of invention are compared with pure cellulose film, and with higher swelling behavior, illustrating chitosan, this is hydrophilic
Property material addition, improve cellulose membrane adsorb wound fluid ability.
In addition, cellulose-based dressings produced by the present invention can be by changing cellulosic substrates used, pressuring method and molten
The conditions such as the difference of liquid species or concentration control the species and function of cellulose-based dressings.
Cellulose-based dressings produced by the present invention are easy to operate, cost is low, can substitute impaired skin and play temporary
Barrier action, it is to avoid or control wound infection can also load various medicines there is provided the environment for being conducive to wound healing, promote wound
Mouth organization healing, is that further clinical practice is laid a good foundation.
Above example is the better embodiment of the present invention, and still, embodiments of the present invention are not limited thereto, but
The modification of all various equivalent form of values to the present invention is replaced, all should be within protection scope of the present invention.
Claims (6)
1. a kind of preparation method of cellulose-based dressings, it is characterised in that comprise the following steps：
1) cellulose solvent is cooled to -12~-5 DEG C in advance, cellulose is then added, stirring and dissolving carries out deaeration, removal of impurities, obtains fine
The plain solution of dimension；
2) by step 1) made from cellulose solution be poured over glass plate one end, solidify it in solidify liquid using the tape casting,
Obtain porous cellulose membrane；
3) using step 2) made from cellulose membrane as the permeable membrane in osmosis device, and prepare surface modification solution, use
Osmosis method makes surface modification solution dynamically pass through cellulose membrane by the hole of cellulose membrane, is finally washed with water, dries, obtains
Described cellulose-based dressings；
The cellulose solvent is alkali/aqueous solution of urea or alkali/thiourea solution；Solidify liquid is water or dilute acid solution；
The surface modification solution is that natural polymer solution, the synthetic polymer solution of natural polymer formation or medicine are molten
Liquid；The mass concentration of natural polymer or synthetic polymer is 0.005~30% in the surface modification solution, in drug solution
The mass concentration of medicine is 0.005~5%.
2. the preparation method of cellulose-based dressings according to claim 1, it is characterised in that the osmosis method is uses
Suction filtration, ultrafiltration or pressuring method.
3. the preparation method of cellulose-based dressings according to claim 1, it is characterised in that the natural polymer is water-soluble
Property chitin, carboxymethyl chitin, chitosan or carboxymethyl chitosan；The synthetic polymer is polyvinyl alcohol, polyvinyl
Pyrrolidones or PEO；The medicine is antimicrobial, analgesics anti-inflammatory or the medicine for promoting wound healing.
4. the preparation method of cellulose-based dressings according to claim 1, it is characterised in that in described cellulose-based dressings
Also contain medicine and/or nano-particle.
5. the preparation method of cellulose-based dressings according to claim 4, it is characterised in that the medicine is antimicrobial, disappeared
One or more in scorching antalgesic, the medicine of promotion wound healing；Nano-particle is with anti-microbial property, promotes wound healing
Nano-particle in one or more.
6. cellulose-based dressings made from any one of Claims 1 to 5 preparation method.
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| CN106390188A (en) * | 2016-04-01 | 2017-02-15 | 浙江理工大学 | Hydrogel having wound repair function and preparation method of hydrogel |
| CN105949486B (en) * | 2016-05-05 | 2018-10-30 | 河南农业大学 | A method of preparing corn stalk fiber element film using maize straw as raw material |
| CN108997620B (en) * | 2018-08-03 | 2021-03-19 | 武汉工程大学 | Carbonate-protected mesoporous silica and cellulose blend membrane and preparation method and application thereof |
| CN109111591B (en) * | 2018-08-24 | 2020-10-09 | 郑州大学 | Preparation method of drug-loaded hemostatic sponge and drug-loaded hemostatic sponge prepared by preparation method |
| CN109731121B (en) * | 2018-12-31 | 2021-11-02 | 武汉工程大学 | Preparation method of cellulose and chitosan composite dressing containing mesoporous silica |
| CN111840633B (en) * | 2019-04-29 | 2022-08-23 | 上海硅健生物材料有限公司 | Skin repairing film and preparation method thereof |
| CN116474153B (en) * | 2022-01-17 | 2024-09-27 | 四川大学 | Skin ulcer nursing film based on bamboo fiber-eutectic solvent-gelatin |
| CN115874440B (en) * | 2022-12-30 | 2023-10-03 | 贵州金玖生物技术有限公司 | Preparation method of water-soluble gauze, product and application thereof |
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| EP1967343A4 (en) * | 2005-12-26 | 2013-05-15 | Konica Minolta Opto Inc | Process for producing cellulose film, apparatus for producing cellulose film, optical film produced by said production apparatus, polarizing plate using said optical film, and liquid crystal display device |
| CN101921410B (en) * | 2010-09-16 | 2012-03-21 | 武汉工程大学 | Method for preparing cellulose microspheres |
| CN104629067B (en) * | 2015-02-16 | 2017-10-27 | 东北林业大学 | A kind of preparation method for regenerating the plain composite membrane of polyvinyl alcohol of antibiotic fiber |
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