CN104906623A - Cellulose-based dressing and preparation method and application thereof - Google Patents
Cellulose-based dressing and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a cellulose-based dressing. A preparation method of the cellulose-based dressing comprises the following steps: 1) precooling a cellulose solvent to minus 12DEG C to minus 5DEG C, adding cellulose, stirring to dissolve the cellulose, defoaming, and removing impurities to obtain a cellulose solution; 2) pouring the cellulose solution onto one end of a glass plate, and curing the cellulose solution in curing liquid by a tape casting method to obtain a porous cellulose membrane; and 3) taking the cellulose membrane prepared in the step 2) as a permeable membrane in a pressure permeator, preparing a surface modification solution, making the surface modification solution dynamically permeate the cellulose membrane via cellulose membrane holes, and finally washing the cellulose membrane with water and drying the cellulose membrane to obtain the cellulose-based dressing. The preparation method provided by the invention is simple, low in cost, green and free of toxin and has good repeatability; and the cellulose-based dressing prepared according to the preparation method has a uniform hole structure, excellent strength and toughness, high transparency, high exudate absorption capacity and a good hemostatic effect, can remarkably promote wound healing, is safe to use and is expected to be popularized and used clinically.
Description
Technical field
The invention belongs to functional high molecule material technical field, be specifically related to a kind of cellulose-based dressings and its preparation method and application.
Background technology
Medical dressing, as the covering of wound, in wound healing process, can substitute impaired skin and play temporary barrier action, avoid or control wound infection, provide the environment being beneficial to wound healing.Along with the aging of population and increasing of chronic ulcerative wound, the market value of medical dressing also becomes more and more important.The second half in 19th century, surgeon Gamgee has invented the Gamgee dressing with water absorption and antibiotic property, i.e. cotton pad.Find that wet environment is conducive to wound healing from British scientist George doctor Winter in 1962, since proposing " wet wound healing is theoretical ", the understanding of people to wound healing process is made to have had breakthrough progress, various new-type dressing obtains broad development, has occurred the series of new dressing such as thin film, foam, aerogel dressing.And current in China, surgical wound still generally uses traditional single dressing such as gauze.Along with the raising of people's quality of life, surgical patients requires also corresponding raising to wound healing, comfort level etc., therefore obtains a kind of dressing being conducive to wound healing and rehabilitation and become one of problem that current scientist pays close attention to.Large quantity research shows, thin film class compounded dressing for wound can keep wound wet union environment, have the microorganism invasions such as biocompatibility, antibiotic property, obstruct antibacterial, allow oxygen to pass through and promote the characteristics such as wound healing, its technology of preparing also more and more receives the concern of people.
Cellulose and its derivates has quite long history as membrane material, plays a part very important " particularly recent years, various performance function cellulose film emerges in an endless stream, and is the focus researched and developed in Cellulose Science " in film industry.Cellulose, as a kind of inexhaustible renewable raw materials, in film industry, has the irreplaceable advantage of synthetic polymer membranes: stable chemical performance; Safety, good biocompatibility; Cost is low; Still there is high strength under hygrometric state; Film forming mechanical strength is good, and thin film fabrication is easy; Be easy to control aperture and porosity.There is potential Development volue.But due to the structure and characteristics of cellulose self, the exploitation of cellulose membrane show the feature being different from other films.Cellulose is that occurring in nature is biodegradable, the good two kinds of natural macromolecular materials of biocompatibility.Cellulose contains great amount of hydroxy group, is easily formed in molecule and intermolecular hydrogen bonding, has certain mechanical strength.Native cellulose molecule and derivant thereof, be pharmaceutically widely used in the objects such as thickening, figuration, slow release, controlled release, film forming.Because its raw material is extensive, good with the compatibility of human body, environment, obtain people and pay close attention to greatly.
Wound healing process is a complicated process, and there is different requirements in different wounds stage different with same wound to dressing.Current any one homogenous material all can not meet the complicated needs of wound healing process, and the dressing major part absorbability that natural material is made is good, has good biocompatibility and biologic activity, but bad mechanical property.Synthesized polymer material isolation performance is good, and mechanical strength is good, but the relative natural material difference of absorbent properties.By the compound to material, the advantage of multiple material can be had concurrently, realizes the requirement of wound healing.As being combined with hydrogel and built up membrane or foam, can also introducing medicine, obtain Drug dressing by physics or chemical method in dressing, they can play again the effect for the treatment of wound simultaneously at protection wound surface.Prepolymer method, completion method, infusion process can be adopted at present to load in dressing carrier by the material with specific function, prepare composite multi-functional dressing.But these preparation methoies also exist some problems, as some base material does not possess natural hole structure, preparation pore structure needs to add porogen, and the later stage may need to remove porogen, technique relative complex; The simple selection of Liquid-liquid mixing masking method to functional mass has certain limitation; Film immersion method may cause function of surface material uneven etc. in film internal coat.
Summary of the invention
The object of this invention is to provide a kind of cellulose-based dressings and its preparation method and application, described preparation method is simple, nontoxic pollution-free, reproducible, and obtained cellulose-based dressings intensity is high, good permeability, effectively can promote wound healing, be applicable to applying.
For achieving the above object, the technical solution used in the present invention is: a kind of preparation method of cellulose-based dressings, comprises the following steps:
1) cellulose solvent is chilled to-12 ~-5 DEG C in advance, then add cellulose (natural polymer cellulose), stirring and dissolving, carries out deaeration, remove impurity, obtains cellulose solution;
2) by step 1) obtained cellulose solution is poured over glass plate one end, and adopt the tape casting in consolidation liquid, make it solidify, obtain the cellulose membrane of porous;
3) using step 2) obtained cellulose membrane is as the permeable membrane in osmosis device, and prepare finishing solution, adopt osmosis method to make finishing solution by the hole of cellulose membrane dynamically through cellulose membrane, finally wash with water, dry, obtain described cellulose-based dressings.
In such scheme, described cellulose solvent is alkali/aqueous solution of urea or alkali/thiourea solution.
Preferably, described cellulose solvent is NaOH/ aqueous solution of urea or NaOH/ thiourea solution.
Preferably, in described cellulose solvent, the mass concentration of sodium hydroxide is 6 ~ 10%, and the mass concentration of carbamide or thiourea is 2 ~ 20%.
Preferably, in gained cellulose solution, cellulosic mass concentration is 0.5 ~ 15%.
In such scheme, described consolidation liquid is water or dilute acid solution.
In such scheme, described osmosis method, for adopting sucking filtration, ultrafiltration or pressuring method, makes finishing solution by the hole of cellulose membrane dynamically through cellulose membrane.
The synthetic polymer solution that in such scheme, described finishing solution is natural polymer solution, natural polymer is formed or drug solution.
In such scheme, described natural polymer is water-soluble chitosan, carboxymethyl chitin, chitosan or carboxymethyl chitosan etc.; Described synthetic polymer is polyvinyl alcohol, polyvinyl pyrrolidone or poly(ethylene oxide); Described medicine is the medicine of antimicrobial drug, anti-inflammatory analgesic or promotion wound healing.
In such scheme, described medicine is antimicrobial drug, one or more in the medicine of anti-inflammatory analgesic and promotion wound healing mix in any proportion.
Preferably, the medicine (as YUNNAN BAIYAO etc.) of described choice of drug antimicrobial drug (as tetracycline, hydroxy tetracycline and gentamycin etc.), anti-inflammatory analgesic (as naproxen sodium salt and aspirin etc.) and/or promotion wound healing.
In such scheme, the mass concentration 0.005 ~ 30% of natural polymer or synthetic polymer in described finishing solution, the mass concentration of drug solution Chinese medicine is 0.005 ~ 5%.
In such scheme, also containing medicine and/or nanoparticle in described cellulose-based dressings.
In such scheme, described medicine is antimicrobial drug, one or more in the medicine of anti-inflammatory analgesic and promotion wound healing mix in any proportion.
Preferably, the medicine (as YUNNAN BAIYAO etc.) of described choice of drug antimicrobial drug (as tetracycline, hydroxy tetracycline and gentamycin etc.), anti-inflammatory analgesic (as naproxen sodium salt and aspirin etc.) and/or promotion wound healing, described medicine preferred mass content is 0.005 ~ 5%.Wherein, cellulose-based dressings drug content refers to the concentration of the drug solution Chinese medicine that cellulose-based dressings soaks.
In such scheme, described nanoparticle be have anti-microbial property, promote wound healing nanoparticle in one or more mix in any proportion.
Preferably, described nanoparticle is one or more in magnetic ferric oxide nanoparticles, titanium dioxide nano-particle, zinc oxide nano-particle, Nano silver grain etc.
In such scheme, step 2) or step 3) described in cellulose membrane can be replaced marketed cellulose film, paper, gauze or cotton.
The cellulose-based dressings obtained according to such scheme can be applicable to biomedicine field.
Beneficial effect of the present invention is:
1) matrix material (cellulose membrane) of dressing of the present invention, complex kind, compound quantity are controlled, substantially increase its range of application.
2) the present invention with the natural polymer cellulose of abundance for raw material, be dissolved in cellulose solvent and prepare cellulose solution, then adopt osmosis legal system for cellulose-based dressings, the preparation method related to is simple, nontoxic pollution-free, reproducible, and do not need to add any chemical adhesive, initiator and porogen, be physical process, there is not chemical reaction, environmental friendliness.
3) dressing that prepared by this method has good biocompatibility and biologic activity, and possess higher hot strength, have loose structure, breathability, moisture retention are good, can not adhesion wound, can epithelial cell growth be accelerated, accelerate the regeneration of new blood capillary, opposing bacterial invasion, prevent wound infection, also can the various medicine of load, promote wound tissue's healing, for further clinical practice is laid a good foundation.
Accompanying drawing explanation
The cellulose-based dressings that Fig. 1 obtains for embodiment 1 is at the shape appearance figure of non-drying regime.
The cellulose-based dressings that Fig. 2 obtains for embodiment 2 is at the shape appearance figure of non-drying regime.
Scanning electron microscope (SEM) figure of the cellulose-based dressings that Fig. 3 obtains for embodiment 3.
The swelling behavior figure of the cellulose-based dressings that Fig. 4 obtains for embodiment 3 and pure cellulose film.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment and accompanying drawing, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
In following examples, as no specific instructions, the reagent of employing is commercially available chemical reagent or industrial products.
Described cellulose is natural polymer cellulose.
Embodiment 1
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 7:12:81) being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 4%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) chitosan solution (finishing solution) that mass concentration is 3% is prepared, using step 2) obtained porous cellulose film is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 2ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 2
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 7:12:81) being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 4%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) chitosan solution (finishing solution) that mass concentration is 1% is prepared, using step 2) obtained porous cellulose film is as the permeable membrane in osmosis device, suction method is adopted to make 10ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 3
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 7:12:81) being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 4%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) chitosan solution (finishing solution) that mass concentration is 3% is prepared, using step 2) obtained perforated membrane is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 10ml chitosan solution through the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 4
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) NaOH/ thiourea solution (mass ratio of sodium hydroxide, thiourea, water is 9.5:4.5:86) being pre-chilled to-5 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 5%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be 9% sulfuric acid solution as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.30mm;
3) chitosan solution (finishing solution) that mass concentration is 5% is prepared, using step 2) obtained porous cellulose film is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 20ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 5
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 7:12:81) being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 15%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) chitosan solution (finishing solution) that mass concentration is 1% is prepared, using step 2) obtained porous cellulose film is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 20ml chitosan solution through the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 6
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 7:12:81) being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 9%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) chitosan solution (finishing solution) that mass concentration is 1% is prepared, using step 2) obtained porous cellulose film is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 20ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 7
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 10:9:81) being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 0.5%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) chitosan solution (finishing solution) that mass concentration is 1% is prepared, using step 2) obtained porous cellulose film is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 20ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 8
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) the NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, aqueous solution is 7:12:81) of magnetic ferric oxide nanoparticles adding 0.421g being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 4%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) chitosan solution (finishing solution) that mass concentration is 15% is prepared, using step 2) obtained porous cellulose film is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 20ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 9
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) the NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 7:12:81) adding 0.889g magnetic ferric oxide nanoparticles being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 4%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) chitosan solution (finishing solution) that mass concentration is 25% is prepared, using step 2) obtained porous cellulose film is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 20ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 10
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) the NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 7:12:81) of the nano titanium oxide adding 0.889g load Nano silver grain being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 4%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) chitosan solution (finishing solution) that mass concentration is 15% is prepared, using step 2) obtained porous cellulose film is as the permeable membrane in osmosis device, suction method is adopted to make 20ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 11
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 7:12:81) being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 4%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) poly-vinyl alcohol solution (finishing solution) that mass concentration is 3% is prepared, using step 2) obtained perforated membrane is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 10ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 12
A preparation method for cellulose-based dressings, concrete steps are as follows:
1) NaOH/ aqueous solution of urea (mass ratio of sodium hydroxide, carbamide, water is 7:12:81) being pre-chilled to-12 DEG C as cellulose solvent dissolving cellulos carries out deaeration, remove impurity, obtains the cellulose solution that cellulose mass concentration is 4%;
2) by step 1) obtained cellulose solution is poured over glass plate one end, preparation mass concentration be the sulfuric acid solution of 5% as consolidation liquid, adopt the tape casting that cellulose solution is solidified in consolidation liquid porous cellulose film that thickness is 0.25mm;
3) tetracycline (finishing solution) that mass concentration is 0.5% is prepared, using step 2) obtained perforated membrane is as the permeable membrane in osmosis device, ultrafiltration is adopted to make 10ml chitosan solution by the hole of cellulose membrane dynamically through cellulose membrane, finally with dry after distilled water wash, obtain described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Embodiment 13
A preparation method for cellulose-based dressings, concrete steps are as follows:
Preparation mass concentration is the chitosan solution of 20wt%, and cotton, as the permeable membrane in osmosis device, adopts the mode of sucking filtration to make 50ml chitosan solution through cotton, finally with dry after distilled water wash, obtains described cellulose-based dressings.
The cellulose-based dressings that the present embodiment obtains can substitute impaired skin and play temporary barrier action, avoids or controls wound infection, provides the environment being beneficial to wound healing.
Fig. 1,2 is respectively embodiment 1 and embodiment 2 obtains the shape appearance figure of cellulose-based dressings in non-drying regime, shows that the cellulose-based dressings color obtained is homogeneous, illustrate that chitosan is attached to cellulose membrane surface uniformly in figure; Fig. 3 is scanning electron microscope (SEM) figure that embodiment 3 obtains cellulose-based dressings, can find out, the cellulose-based dressings that the present invention obtains presents micro-nano pore structure, illustrate that the introducing of chitosan does not change the natural pore structure of cellulose membrane, between composite membrane two material, the compatibility is good; Fig. 4 is the swelling behavior figure that embodiment 3 obtains cellulose-based dressings and pure cellulose film, as can be seen from Figure 4, the cellulose-based dressings that the present invention obtains is compared with pure cellulose film, there is higher swelling behavior, adding of this hydroaropic substance of chitosan is described, improves the ability of cellulose membrane absorption wound fluid.
In addition, the cellulose-based dressings that the present invention obtains can control kind and the function of cellulose-based dressings by changing the conditions such as the difference of cellulosic substrates used, pressuring method and solution type or concentration.
The cellulose-based dressings that the present invention obtains is easy and simple to handle, cost is low, impaired skin can be substituted and play temporary barrier action, avoid or control wound infection, provide the environment being beneficial to wound healing, also can the various medicine of load, promote wound tissue's healing, for further clinical practice is laid a good foundation.
Above embodiment is better embodiment of the present invention, but embodiments of the present invention are not limited thereto, as long as replace the amendment of the various equivalent form of value of the present invention, and all should within protection scope of the present invention.
Claims (10)
1. a preparation method for cellulose-based dressings, is characterized in that, comprises the following steps:
1) cellulose solvent is chilled to-12 ~-5 DEG C in advance, then adds cellulose, stirring and dissolving, carry out deaeration, remove impurity, obtain cellulose solution;
2) by step 1) obtained cellulose solution is poured over glass plate one end, and adopt the tape casting in consolidation liquid, make it solidify, obtain the cellulose membrane of porous;
3) using step 2) obtained cellulose membrane is as the permeable membrane in osmosis device, and prepare finishing solution, adopt osmosis method to make finishing solution by the hole of cellulose membrane dynamically through cellulose membrane, finally wash with water, dry, obtain described cellulose-based dressings.
2. the preparation method of cellulose-based dressings according to claim 1, it is characterized in that, described cellulose solvent is alkali/aqueous solution of urea or alkali/thiourea solution; Consolidation liquid is water or dilute acid solution.
3. the preparation method of cellulose-based dressings according to claim 1, is characterized in that, described osmosis method is for adopting sucking filtration, ultrafiltration or pressuring method.
4. the preparation method of cellulose-based dressings according to claim 1, is characterized in that, the synthetic polymer solution that described finishing solution is natural polymer solution, natural polymer is formed or drug solution; In described finishing solution, the mass concentration of natural polymer or synthetic polymer is 0.005 ~ 30%, and the mass concentration of drug solution Chinese medicine is 0.005 ~ 5%.
5. the preparation method of cellulose-based dressings according to claim 4, it is characterized in that, described natural polymer is water-soluble chitosan, carboxymethyl chitin, chitosan or carboxymethyl chitosan; Described synthetic polymer is polyvinyl alcohol, polyvinyl pyrrolidone or poly(ethylene oxide); Described medicine is the medicine of antimicrobial drug, anti-inflammatory analgesic or promotion wound healing.
6. the preparation method of cellulose-based dressings according to claim 1, is characterized in that, also containing medicine and/or nanoparticle in described cellulose-based dressings.
7. the preparation method of cellulose-based dressings according to claim 6, is characterized in that, described medicine is one or more in the medicine of antimicrobial drug, anti-inflammatory analgesic, promotion wound healing; Nanoparticle be have anti-microbial property, promote wound healing nanoparticle in one or more.
8. the preparation method of cellulose-based dressings according to claim 1, is characterized in that, step 2) or step 3) described in cellulose membrane can be replaced marketed cellulose film, paper, gauze or cotton.
9. the cellulose-based dressings that preparation method described in any one of claim 1 ~ 9 is obtained.
10. the cellulose-based dressings that described in any one of claim 1 ~ 9, preparation method obtains is in the application of biomedicine field.
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| US20070148371A1 (en) * | 2005-12-26 | 2007-06-28 | Konica Minolta Opto, Inc. | Method of manufacturing cellulose film, manufacturing apparatus, optical film, polarizing plate and liquid crystal display |
| CN101921410A (en) * | 2010-09-16 | 2010-12-22 | 武汉工程大学 | Method for preparing cellulose microspheres |
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