CN106039391A - Anti-bacterial high-viscosity medical glue and preparation method thereof - Google Patents
Anti-bacterial high-viscosity medical glue and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an anti-bacterial high-viscosity medical glue, which is prepared from the following ingredients: 2-cyano-acrylate isopropyl, polyisoprene, polypropylene, povidone iodine, magnesium sulfate, naringenin, halloysitum rubrum nano-powder, vitamin A palmitate, plant essential oil, paraffins, alginate, disodium EDTA, methacrylamide, polyvinyl alcohol, dioctyl phthalate, 1.5g/ml luffa extract, 0.8g/ml rhizoma bletillae extract, glycerol and sterile water. The invention further discloses a preparation method of the anti-bacterial high-viscosity medical glue. The adhesive strength and 48-hour compressive strength of the medical glue are in a relatively high level, the medical glue is high in anti-bacterial ratio, short in hemostasis time, high in overall healing efficiency, free from irritation on wound tissues and excellent in overall performance, and conforms to the application requirements of clinics for the medical glue.
Description
Technical field
The invention belongs to medical material tech field, be specifically related to the medical glue of a kind of antibacterial high bonding and preparation side thereof
Method.
Background technology
In daily life, inevitably being injured by external environment, generation scar, wound are bled the most in a large number,
For in this case, light the wounded can be carried out wrapping and process wound by the wrapper material such as commonly used gauze, but the wrapping such as gauze
Material had both easily caused wound infection, and the most used wrapper material also needs to subsequent treatment, otherwise pollutes the environment.This
Outward, wrapper material needs to tear the wrapper material that replacement is new, during tearing in use for some time, it is easy to right
Wound tissue causes secondary injury, brings violent pain to user.Weight the wounded needs to use medical line to sew up, this
Adds additional the pain of patient undoubtedly, it is also desirable to special early stage is disinfected, bring inconvenience to actually used.
In order to solve these problems, medical glue is to substitute wrapper material and the emerging curable product of suture needle, the most medical
The main component of glue is a-cyanoacrylate, it has, and the polymerization speed in biological tissue is fast, quick-acting haemostatic powder, pain relieving and
Promote the effects such as wound healing.But the adhesion strength of existing medical glue is inadequate, wound easily ftractures because of motion and bleeds,
Additionally, there may be antibacterial effect poor, easily cause wound infection, and easily biological tissue is brought the deficiencies such as certain stimulation.
Summary of the invention
Based on above prior art, it is an object of the invention to provide the medical glue of a kind of antibacterial high bonding and preparation side thereof
Method.
It is an object of the invention to be achieved through the following technical solutions:
The medical glue of a kind of antibacterial high bonding, including the component of following parts by weight: 2-isopropyl cyanoacrylate 40-58 part,
Polyisoprene 25-36 part, polypropylene 18-25 part, povidone iodine 4-8 part, magnesium sulfate 3-6 part, naringenin 3-7 part, Halloysitum Rubrum
Nano powder 2-4 part, vitamin A palmitate 5-9 part, plants essential oil 2-6 part, paraffin 2-4 part, alginate 2-4 part, EDTA bis-
Sodium 1-5 part, Methacrylamide 4-8 part, polyvinyl alcohol 4-7 part, o-phthalic acid dibutyl ester 3-6 part, 1.5g/ml Fructus Luffae extract
Thing 2-4 part, 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract 1-3 part, glycerol 150-200 part, sterilized water 100-160 part.
Preferably, including the component of following parts by weight: 2-isopropyl cyanoacrylate 46 parts, polyisoprene 27 parts,
Polypropylene 21 parts, povidone iodine 5 parts, 5 parts of magnesium sulfate, naringenin 4 parts, Halloysitum Rubrum nano powder 3 parts, vitamin A palmitate 5.8
Part, plants essential oil 4 parts, 2.5 parts of paraffin, alginate 2.2 parts, EDETATE SODIUM 2.4 parts, Methacrylamide 4 parts, polyvinyl alcohol
6 parts, o-phthalic acid dibutyl ester 4.8 parts, 1.5g/ml Fructus Luffae extract 2.8 parts, 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract 1.6 parts, glycerol
186 parts, sterilized water 145 parts.
Described plants essential oil is Fructus Litseae essential oil, lemon grass (Cymbopogon citratus) quintessence oil and the mixture of fennel essential oil.
Described plants essential oil is the mixture that weight ratio is 5:2:1 of Fructus Litseae essential oil, lemon grass (Cymbopogon citratus) quintessence oil and fennel essential oil.
Described Fructus Luffae extract is ethanol or the methanol extract liquid of Fructus Luffae, and concrete extraction step is: take dry Luffa powder
Broken, add ethanol or the methanol solution of the 75-95% mass concentration of 20-50 times of weight, soak 24-72 hour, filter centrifugation, take
Supernatant, concentrated by rotary evaporation to concentration is 1.5g/ml, and concentrated solution is degerming through microporous filter membrane device, obtains Fructus Luffae extract.
Described Pseudobulbus Bletillae (Rhizoma Bletillae) extract is ethanol or the methanol extract liquid of Pseudobulbus Bletillae (Rhizoma Bletillae), and concrete extraction step is: take dry Rhizoma Bletillae powder
Broken, add ethanol or the methanol solution of the 75-95% mass concentration of 15-40 times of weight, soak 24-72 hour, filter centrifugation, take
Supernatant, concentrated by rotary evaporation to concentration is 0.8g/ml, and concentrated solution is degerming through microporous filter membrane device, obtains Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
Described alginate is sodium alginate or potassium alginate.
The above-mentioned antibacterial high preparation method bonding medical glue, comprises the following steps:
Magnesium sulfate, naringenin, alginate and polyvinyl alcohol are added in deionized water, is heated to 80-90 DEG C, stirring and dissolving
60-120min, is cooled to room temperature, obtains aqueous solution；
2-isopropyl cyanoacrylate, polyisoprene, paraffin, polypropylene are placed in glycerol, are heated to 60-75 DEG C of stirring
20-60min, is cooled to room temperature, obtains glycerite；
By above-mentioned aqueous solution and glycerite mix homogeneously, and add surplus stock, stir 1-3 hour, process through filtration sterilization,
Obtain the medical glue of antibacterial high bonding.
Owing to have employed above technical scheme, there is advantages that
The medical glue adhesion strength of the present invention and 48 hours comprcssive strength are all in higher level, and to staphylococcus aureus
Antibiotic rate be up to more than 97.5%, to the bleeding stopping period of wound less than 115 seconds, overall healing efficiency is up to more than 98%, cures
Rate is high, and non-stimulated to wound tissue, combination property is outstanding, meets the clinical application requirement to medical glue；Additionally, institute of the present invention
State preparation method simple to operate, easily realize industrialization, there is environment friendly.
Detailed description of the invention
Below by embodiment, the present invention is specifically described, it is necessary to it is pointed out here that be that following example are only used
In being further described the present invention, it is impossible to be interpreted as limiting the scope of the invention, person skilled in art can
The present invention made some nonessential improvement and adjustment according to the invention described above content.
Embodiment 1
A kind of antibacterial high bond medical glue, including the component of following parts by weight: 2-isopropyl cyanoacrylate 40 parts, poly-different
Pentadiene 25 parts, polypropylene 18 parts, povidone iodine 4 parts, 3 parts of magnesium sulfate, naringenin 3 parts, Halloysitum Rubrum nano powder 2 parts, vitamin A
Cetylate 5 parts, plants essential oil 2 parts, 2 parts of paraffin, alginate 2 parts, EDETATE SODIUM 1 part, Methacrylamide 4 parts, poly-second
Enol 4 parts, o-phthalic acid dibutyl ester 3 parts, 1.5g/ml Fructus Luffae extract 2 parts, 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract 1 part, glycerol 150
Part, sterilized water 100 parts.
Described plants essential oil is the mixture that weight ratio is 3:1:2 of Fructus Litseae essential oil, lemon grass (Cymbopogon citratus) quintessence oil and fennel essential oil.
Described Fructus Luffae extract is ethanol or the methanol extract liquid of Fructus Luffae, and concrete extraction step is: take dry Luffa powder
Broken, add ethanol or the methanol solution of 75% mass concentration of 20 times of weight, soak 24 hours, filter centrifugation, take supernatant, rotation
It is 1.5g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Fructus Luffae extract.
Described Pseudobulbus Bletillae (Rhizoma Bletillae) extract is ethanol or the methanol extract liquid of Pseudobulbus Bletillae (Rhizoma Bletillae), and concrete extraction step is: take dry Rhizoma Bletillae powder
Broken, add ethanol or the methanol solution of 75% mass concentration of 15 times of weight, soak 24 hours, filter centrifugation, take supernatant, rotation
It is 0.8g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
Described alginate is sodium alginate.
The above-mentioned antibacterial high preparation method bonding medical glue, comprises the following steps:
Magnesium sulfate, naringenin, alginate and polyvinyl alcohol are added in deionized water, is heated to 80 DEG C, stirring and dissolving
600min, is cooled to room temperature, obtains aqueous solution；
2-isopropyl cyanoacrylate, polyisoprene, paraffin, polypropylene are placed in glycerol, are heated to 60 DEG C of stirrings
20min, is cooled to room temperature, obtains glycerite；
By above-mentioned aqueous solution and glycerite mix homogeneously, and add surplus stock, stir 1 hour, process through filtration sterilization, i.e.
Obtain the medical glue of antibacterial high bonding.
Embodiment 2
A kind of antibacterial high bond medical glue, including the component of following parts by weight: 2-isopropyl cyanoacrylate 49 parts, poly-different
Pentadiene 30 parts, polypropylene 21 parts, povidone iodine 6 parts, 4 parts of magnesium sulfate, naringenin 5 parts, Halloysitum Rubrum nano powder 3 parts, vitamin A
Cetylate 7 parts, plants essential oil 4 parts, 3 parts of paraffin, alginate 3 parts, EDETATE SODIUM 3 parts, Methacrylamide 6 parts, poly-second
Enol 5 parts, o-phthalic acid dibutyl ester 4 parts, 1.5g/ml Fructus Luffae extract 3 parts, 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract 2 parts, glycerol 175
Part, sterilized water 130 parts.
Described plants essential oil is the mixture that weight ratio is 3:2:1 of Fructus Litseae essential oil, lemon grass (Cymbopogon citratus) quintessence oil and fennel essential oil.
Described Fructus Luffae extract is ethanol or the methanol extract liquid of Fructus Luffae, and concrete extraction step is: take dry Luffa powder
Broken, add ethanol or the methanol solution of 85% mass concentration of 35 times of weight, soak 46 hours, filter centrifugation, take supernatant, rotation
It is 1.5g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Fructus Luffae extract.
Described Pseudobulbus Bletillae (Rhizoma Bletillae) extract is ethanol or the methanol extract liquid of Pseudobulbus Bletillae (Rhizoma Bletillae), and concrete extraction step is: take dry Rhizoma Bletillae powder
Broken, add ethanol or the methanol solution of 85% mass concentration of 22 times of weight, soak 48 hours, filter centrifugation, take supernatant, rotation
It is 0.8g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
Described alginate is sodium alginate.
The above-mentioned antibacterial high preparation method bonding medical glue, comprises the following steps:
Magnesium sulfate, naringenin, alginate and polyvinyl alcohol are added in deionized water, is heated to 85 DEG C, stirring and dissolving
90min, is cooled to room temperature, obtains aqueous solution；
2-isopropyl cyanoacrylate, polyisoprene, paraffin, polypropylene are placed in glycerol, are heated to 67 DEG C of stirrings
40min, is cooled to room temperature, obtains glycerite；
By above-mentioned aqueous solution and glycerite mix homogeneously, and add surplus stock, stir 2 hours, process through filtration sterilization, i.e.
Obtain the medical glue of antibacterial high bonding.
Embodiment 3
A kind of antibacterial high bond medical glue, including the component of following parts by weight: 2-isopropyl cyanoacrylate 58 parts, poly-different
Pentadiene 36 parts, polipropene 25 part, povidone iodine 8 parts, 6 parts of magnesium sulfate, naringenin 7 parts, Halloysitum Rubrum nano powder 4 parts, vitamin A
Cetylate 9 parts, plants essential oil 6 parts, 4 parts of paraffin, alginate 4 parts, EDETATE SODIUM 5 parts, Methacrylamide 8 parts, poly-second
Enol 7 parts, o-phthalic acid dibutyl ester 6 parts, 1.5g/ml Fructus Luffae extract 4 parts, 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract 3 parts, glycerol 200
Part, sterilized water 160 parts.
Described plants essential oil is the mixture that weight ratio is 2:1:1 of Fructus Litseae essential oil, lemon grass (Cymbopogon citratus) quintessence oil and fennel essential oil.
Described Fructus Luffae extract is ethanol or the methanol extract liquid of Fructus Luffae, and concrete extraction step is: take dry Luffa powder
Broken, add ethanol or the methanol solution of 95% mass concentration of 50 times of weight, soak 72 hours, filter centrifugation, take supernatant, rotation
It is 1.5g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Fructus Luffae extract.
Described Pseudobulbus Bletillae (Rhizoma Bletillae) extract is ethanol or the methanol extract liquid of Pseudobulbus Bletillae (Rhizoma Bletillae), and concrete extraction step is: take dry Rhizoma Bletillae powder
Broken, add ethanol or the methanol solution of 95% mass concentration of 40 times of weight, soak 72 hours, filter centrifugation, take supernatant, rotation
It is 0.8g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
Described alginate is potassium alginate.
The above-mentioned antibacterial high preparation method bonding medical glue, comprises the following steps:
Magnesium sulfate, naringenin, alginate and polyvinyl alcohol are added in deionized water, is heated to 90 DEG C, stirring and dissolving
120min, is cooled to room temperature, obtains aqueous solution；
2-isopropyl cyanoacrylate, polyisoprene, paraffin, polypropylene are placed in glycerol, are heated to 75 DEG C of stirrings
60min, is cooled to room temperature, obtains glycerite；
By above-mentioned aqueous solution and glycerite mix homogeneously, and add surplus stock, stir 1-3 hour, process through filtration sterilization,
Obtain the medical glue of antibacterial high bonding.
Embodiment 4
A kind of antibacterial high bond medical glue, including the component of following parts by weight: 2-isopropyl cyanoacrylate 46 parts, poly-different
Pentadiene 27 parts, polypropylene 21 parts, povidone iodine 5 parts, 5 parts of magnesium sulfate, naringenin 4 parts, Halloysitum Rubrum nano powder 3 parts, vitamin A
Cetylate 5.8 parts, plants essential oil 4 parts, 2.5 parts of paraffin, alginate 2.2 parts, EDETATE SODIUM 2.4 parts, Methacrylamide 4
Part, polyvinyl alcohol 6 parts, o-phthalic acid dibutyl ester 4.8 parts, 1.5g/ml Fructus Luffae extract 2.8 parts, 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract
1.6 parts, glycerol 186 parts, sterilized water 145 parts.
Described plants essential oil is the mixture that weight ratio is 5:2:1 of Fructus Litseae essential oil, lemon grass (Cymbopogon citratus) quintessence oil and fennel essential oil.
Described Fructus Luffae extract is ethanol or the methanol extract liquid of Fructus Luffae, and concrete extraction step is: take dry Luffa powder
Broken, add ethanol or the methanol solution of 80% mass concentration of 40 times of weight, soak 48 hours, filter centrifugation, take supernatant, rotation
It is 1.5g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Fructus Luffae extract.
Described Pseudobulbus Bletillae (Rhizoma Bletillae) extract is ethanol or the methanol extract liquid of Pseudobulbus Bletillae (Rhizoma Bletillae), and concrete extraction step is: take dry Rhizoma Bletillae powder
Broken, add ethanol or the methanol solution of 85% mass concentration of 30 times of weight, soak 48 hours, filter centrifugation, take supernatant, rotation
It is 0.8g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
Described alginate is sodium alginate or potassium alginate.
The above-mentioned antibacterial high preparation method bonding medical glue, comprises the following steps:
Magnesium sulfate, naringenin, alginate and polyvinyl alcohol are added in deionized water, is heated to 88 DEG C, stirring and dissolving
100min, is cooled to room temperature, obtains aqueous solution；
2-isopropyl cyanoacrylate, polyisoprene, paraffin, polypropylene are placed in glycerol, are heated to 72 DEG C of stirrings
50min, is cooled to room temperature, obtains glycerite；
By above-mentioned aqueous solution and glycerite mix homogeneously, and add surplus stock, stir 3 hours, process through filtration sterilization, i.e.
Obtain the medical glue of antibacterial high bonding.
Embodiment 5
A kind of antibacterial high bond medical glue, including the component of following parts by weight: 2-isopropyl cyanoacrylate 52 parts, poly-different
Pentadiene 27 parts, polypropylene 20 parts, povidone iodine 7 parts, 5 parts of magnesium sulfate, naringenin 4 parts, Halloysitum Rubrum nano powder 2.2 parts, dimension are raw
Element A cetylate 5 parts, plants essential oil 4 parts, 2.6 parts of paraffin, alginate 3 parts, EDETATE SODIUM 4 parts, Methacrylamide 5 parts,
Polyvinyl alcohol 5 parts, o-phthalic acid dibutyl ester 3.5 parts, 1.5g/ml Fructus Luffae extract 3 parts, 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract 1.8
Part, glycerol 175 parts, sterilized water 130 parts.
Described plants essential oil is the mixture that weight ratio is 4:1:2 of Fructus Litseae essential oil, lemon grass (Cymbopogon citratus) quintessence oil and fennel essential oil.
Described Fructus Luffae extract is ethanol or the methanol extract liquid of Fructus Luffae, and concrete extraction step is: take dry Luffa powder
Broken, add ethanol or the methanol solution of 80% mass concentration of 40 times of weight, soak 72 hours, filter centrifugation, take supernatant, rotation
It is 1.5g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Fructus Luffae extract.
Described Pseudobulbus Bletillae (Rhizoma Bletillae) extract is ethanol or the methanol extract liquid of Pseudobulbus Bletillae (Rhizoma Bletillae), and concrete extraction step is: take dry Rhizoma Bletillae powder
Broken, add ethanol or the methanol solution of 80% mass concentration of 30 times of weight, soak 48 hours, filter centrifugation, take supernatant, rotation
It is 0.8g/ml that inspissation is reduced to concentration, and concentrated solution is degerming through microporous filter membrane device, obtains Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
Described alginate is potassium alginate.
The above-mentioned antibacterial high preparation method bonding medical glue, comprises the following steps:
Magnesium sulfate, naringenin, alginate and polyvinyl alcohol are added in deionized water, is heated to 85 DEG C, stirring and dissolving
80min, is cooled to room temperature, obtains aqueous solution；
2-isopropyl cyanoacrylate, polyisoprene, paraffin, polypropylene are placed in glycerol, are heated to 68 DEG C of stirrings
30min, is cooled to room temperature, obtains glycerite；
By above-mentioned aqueous solution and glycerite mix homogeneously, and add surplus stock, stir 3 hours, process through filtration sterilization, i.e.
Obtain the medical glue of antibacterial high bonding.
Comparative example 1
This comparative example is in place of the difference of embodiment 1: without 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract, vitamin A palmitate and red
Halloysitum Rubrum nano powder.
Comparative example 2
This comparative example is in place of the difference of embodiment 1: without naringenin, povidone iodine and plants essential oil.
Performance test
Using above-described embodiment and comparative example to prepare medical glue and smear wound, and carry out correlated performance test, it is surveyed
Test result is:
Can be seen that from upper table, the medical glue adhesion strength of the present invention and 48 hours comprcssive strength all in higher level,
And the antibiotic rate of staphylococcus aureus is up to more than 97.5%, the bleeding stopping period of wound is less than 115 seconds, overall healing effect
Rate is up to more than 98%, and cure rate is high, and non-stimulated to wound tissue, combination property is outstanding, meets the clinical application to medical glue
Requirement.
Claims (8)
1. the medical glue of antibacterial high bonding, it is characterised in that include the component of following parts by weight: 2-alpha-cyanoacrylate is different
Propyl ester 40-58 part, polyisoprene 25-36 part, polypropylene 18-25 part, povidone iodine 4-8 part, magnesium sulfate 3-6 part, naringenin
3-7 part, Halloysitum Rubrum nano powder 2-4 part, vitamin A palmitate 5-9 part, plants essential oil 2-6 part, paraffin 2-4 part, alginate
2-4 part, EDETATE SODIUM 1-5 part, Methacrylamide 4-8 part, polyvinyl alcohol 4-7 part, o-phthalic acid dibutyl ester 3-6 part,
1.5g/ml Fructus Luffae extract 2-4 part, 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract 1-3 part, glycerol 150-200 part, sterilized water 100-160 part.
The medical glue of antibacterial high bonding the most according to claim 1, it is characterised in that include the group of following parts by weight
Point: 2-isopropyl cyanoacrylate 46 parts, polyisoprene 27 parts, polypropylene 21 parts, povidone iodine 5 parts, 5 parts of magnesium sulfate, Fructus Citri grandis
Skin element 4 parts, Halloysitum Rubrum nano powder 3 parts, vitamin A palmitate 5.8 parts, plants essential oil 4 parts, 2.5 parts of paraffin, alginate
2.2 parts, EDETATE SODIUM 2.4 parts, Methacrylamide 4 parts, polyvinyl alcohol 6 parts, o-phthalic acid dibutyl ester 4.8 parts, 1.5g/ml
Fructus Luffae extract 2.8 parts, 0.8g/ml Pseudobulbus Bletillae (Rhizoma Bletillae) extract 1.6 parts, glycerol 186 parts, sterilized water 145 parts.
The medical glue of antibacterial high bonding the most according to claim 1 and 2, it is characterised in that described plants essential oil is that mountain is grey
Sub-quintessence oil, lemon grass (Cymbopogon citratus) quintessence oil and the mixture of fennel essential oil.
The medical glue of antibacterial high bonding the most according to claim 1 and 2, it is characterised in that described plants essential oil is that mountain is grey
The mixture that weight ratio is 5:2:1 of sub-quintessence oil, lemon grass (Cymbopogon citratus) quintessence oil and fennel essential oil.
The medical glue of antibacterial high bonding the most according to claim 1 and 2, it is characterised in that described Fructus Luffae extract is silk
The ethanol of melon or methanol extract liquid, concrete extraction step is: takes dry Fructus Luffae and pulverizes, adds the 75-95% of 20-50 times of weight
The ethanol of mass concentration or methanol solution, soak 24-72 hour, filter centrifugation, take supernatant, and concentrated by rotary evaporation to concentration is
1.5g/ml, concentrated solution is degerming through microporous filter membrane device, obtains Fructus Luffae extract.
The medical glue of antibacterial high bonding the most according to claim 1 and 2, it is characterised in that described Pseudobulbus Bletillae (Rhizoma Bletillae) extract is white
And ethanol or methanol extract liquid, concrete extraction step is: takes dry Pseudobulbus Bletillae (Rhizoma Bletillae) and pulverizes, adds the 75-95% of 15-40 times of weight
The ethanol of mass concentration or methanol solution, soak 24-72 hour, filter centrifugation, take supernatant, and concentrated by rotary evaporation to concentration is
0.8g/ml, concentrated solution is degerming through microporous filter membrane device, obtains Pseudobulbus Bletillae (Rhizoma Bletillae) extract.
The medical glue of antibacterial high bonding the most according to claim 1 and 2, it is characterised in that described alginate is Sargassum
Acid sodium or potassium alginate.
8. the antibacterial high preparation method bonding medical glue as described in claim 1-7 is arbitrary, it is characterised in that include following
Step:
Magnesium sulfate, naringenin, alginate and polyvinyl alcohol are added in deionized water, is heated to 80-90 DEG C, stirring and dissolving
60-120min, is cooled to room temperature, obtains aqueous solution；
2-isopropyl cyanoacrylate, polyisoprene, paraffin, polypropylene are placed in glycerol, are heated to 60-75 DEG C of stirring
20-60min, is cooled to room temperature, obtains glycerite；
By above-mentioned aqueous solution and glycerite mix homogeneously, and add surplus stock, stir 1-3 hour, process through filtration sterilization,
Obtain the medical glue of antibacterial high bonding.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107126578A (en) * | 2017-04-21 | 2017-09-05 | 常州市蓝勖化工有限公司 | A kind of preparation method of adhesive of medical |
| CN107412846A (en) * | 2017-07-27 | 2017-12-01 | 苏州凌科特新材料有限公司 | A kind of composite antibacterial medical adhesive and preparation method thereof |
| CN108452369A (en) * | 2018-06-21 | 2018-08-28 | 浙江派菲特新材料科技有限公司 | A kind of preparation method of high anti-microbial property adhesive of medical |
| CN108635618A (en) * | 2018-08-01 | 2018-10-12 | 浙江派菲特新材料科技有限公司 | It is a kind of that there is the preparation method for promoting healing and repair function medical adhesive |
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| CN107126578A (en) * | 2017-04-21 | 2017-09-05 | 常州市蓝勖化工有限公司 | A kind of preparation method of adhesive of medical |
| CN107412846A (en) * | 2017-07-27 | 2017-12-01 | 苏州凌科特新材料有限公司 | A kind of composite antibacterial medical adhesive and preparation method thereof |
| CN108686257A (en) * | 2018-06-21 | 2018-10-23 | 浙江派菲特新材料科技有限公司 | A kind of high anti-microbial property adhesive of medical |
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| CN108904870A (en) * | 2018-08-01 | 2018-11-30 | 浙江派菲特新材料科技有限公司 | A kind of medical adhesive with promotion healing and repair function |
| CN108635618A (en) * | 2018-08-01 | 2018-10-12 | 浙江派菲特新材料科技有限公司 | It is a kind of that there is the preparation method for promoting healing and repair function medical adhesive |
| CN108888801A (en) * | 2018-08-04 | 2018-11-27 | 浙江派菲特新材料科技有限公司 | A kind of medical adhesive with efficient anti-inflammatory hemostatic function |
| CN108939139A (en) * | 2018-08-04 | 2018-12-07 | 浙江派菲特新材料科技有限公司 | A kind of preparation method with efficient anti-inflammatory hemostatic function medical adhesive |
| CN108888801B (en) * | 2018-08-04 | 2020-10-30 | 浙江派菲特新材料科技有限公司 | Medical glue with efficient anti-inflammatory and hemostatic functions |
| CN109173020A (en) * | 2018-09-30 | 2019-01-11 | 南宁腾科宝迪生物科技有限公司 | A kind of multi-functional abdominal suction of safely and effectively anti-blocking noninvasive anti-absorption |
| CN109173020B (en) * | 2018-09-30 | 2021-12-07 | 南宁腾科宝迪生物科技有限公司 | Safe and effective anti-blocking noninvasive adsorption-preventing multifunctional abdominal cavity drainage tube |
| CN110343471A (en) * | 2019-07-12 | 2019-10-18 | 杭州厚瑞科技有限公司 | A kind of medical instrument production line profession glue and preparation method thereof |
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Application publication date: 20161026 |