CN108686257A - A kind of high anti-microbial property adhesive of medical - Google Patents

Abstract

The present invention relates to a kind of high anti-microbial property adhesive of medical, which is characterized in that includes the component of following parts by weight:45-55 parts of poly- (isobutyl alpha-cyanoacrylate-alpha-cyanoacrylate monooctyl ester), 24-36 parts of high-efficiency antimicrobial component, 2-5 parts of polyurethane, 20-25 parts of polyisoprene, 2-4 parts of sodium alginate, 3-6 parts of lignin, 7-10 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, 150-200 parts of Seabuckthorm Seed Oil, 180 parts of sterile water.The adhesive of medical of the present invention has been especially added with three big antibacterial components antibiotic rates height, and adhesion strength is high, good biocompatibility, and whole cure rate is high, meets the clinical application requirement to adhesive of medical.

Description

A kind of high anti-microbial property adhesive of medical

Technical field

The invention belongs to medical material tech fields, and in particular to a kind of high anti-microbial property adhesive of medical.

Background technology

With the progress of medicine, the requirement clinically to surgical technic and auxiliary material effect is higher and higher.Modern medicine Theory be to reduce the pain of patient to the maximum extent, it is medical high score to allow to prestissimo patients ' recovery, adhesive of medical One branch of son, it is bonding object with biological tissue, and human body overwhelming majority tissue, organ can answer over the course for the treatment of Part is replaced to suture with adhering technique, ligation operation, it is not necessary to anaesthetize;Automatic-falling after wound healing.Compared with conventional method, doctor Operating time can be effectively shortened with the use of adhesive, reduce patient pain's sense.

The main direction of studying of adhesive of medical is to improve the adhesion strength of various adhesives at present, however outer at present The bio-medical material applied in section's operation does not have bacterial immune function, is easy to bacterial adhesion and breeding, becomes surrounding tissue The source of infection, to patient bring it is huge spirit and economic pressures, assign medical material antibacterial activity be solve this problem it is unique Effective way.The generation of formaldehyde generates side effect to bio-tissue during the storage of cyanoacrylate medical adhesive, use, and And as the increase of concentration of formaldehyde increases the damage of organism, effect and the application of adhesive of medical are seriously affected.

Invention content

Based on the above prior art, the purpose of the present invention is to provide a kind of a variety of effective antibacterial components of combination to greatly improve Antibacterial effect, while effectively inhibiting formaldehyde to generate, avoiding wound infection and there is high antibacterial to what biological tissue caused to stimulate Performance adhesive of medical and preparation method thereof.

The purpose of the present invention is what is be achieved through the following technical solutions:

A kind of high anti-microbial property adhesive of medical, which is characterized in that include the component of following parts by weight:Poly- (alpha-cyano Isobutyl acrylate-alpha-cyanoacrylate monooctyl ester) 45-55 parts, 24-36 parts of high-efficiency antimicrobial component, 2-5 parts of polyurethane, poly- isoamyl 20-25 parts of diene, 2-4 parts of sodium alginate, 3-6 parts of lignin, 7-10 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, sand 150-200 parts of spine seed oil, 180 parts of sterile water;

The high-efficiency antimicrobial component includes that 5 parts of special efficacy nano-antibacterial component, 12-18 parts of natural antibacterial components, Chinese medicine are anti- 5-10 parts of bacterium component;

The special efficacy nano-antibacterial component is by Ag-carried nanometer titanium dioxide, chlorhexidine acetate-montmorillonite and graphite oxide Alkene is 2 according to weight part ratio:2:1 mixes;

The natural antibacterial components in parts by weight, including 2 parts of butterfly berry extract, Black Box Tracing extraction 2 parts of object, 2 parts of 3 parts of Artemisinin, 2 parts of mulberry bark extract, 2 parts of citrus peel extract and phllostachys pubescens leaf ext;

The Chinese medicine antibacterial component in parts by weight, including 1 part of Extract of Euphorbiae, Yunnan Lindley Butterflybush Herb extract 1 part of 2 parts, 2 parts of Radix Ampelopsis extract, 2 parts of licorice and Radix Gentianae Macrophyllae extract.

Further, the formaldehyde inhibitor is benzoguanamine and hydantoins according to weight fraction 1:4 are composed.

Further, the butterfly berry extract is the ethanol extract of sinopimelodendron kwangsiense, and specific extraction step is:Take dry butterfly Butterfly fruit crushed 60 mesh sieve, and the ethanol solution of 95% mass concentration of 18 times of weight is added, and impregnate 80h, filter, in 3000rpm/ 15min is centrifuged under min rotating speeds;Supernatant is taken, concentrated by rotary evaporation to a concentration of 1.5g/ml, concentrate is through miillpore filter device degerming, i.e., Obtain butterfly berry extract.

Further, the system of the Artemisinin, mulberry bark extract, citrus peel extract and phllostachys pubescens leaf ext Preparation Method specifically includes following steps:By above-mentioned each raw material through drying, beat powder respectively after sieve with 100 mesh sieve, respectively obtain each raw material Powder, 95% ethanol solution is then added, under the conditions of 45 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 35min is obtained Extracting solution;Extracting solution is filtered and is concentrated under reduced pressure, slurry is obtained;By slurry with 1:12 volume ratios are dissolved in deionized water, through stirring Mix, shake up, after miillpore filter device degerming, respectively each raw extract.

Further, the preparation method of the Black Box Tracing extract is as follows:It is described to wash away black fruit gland with circulating water Rib Sorbus alnifloria table and silt, ozone generator is passed through in sterile water and cleans Black Box Tracing again, and pulp crushing is broken into fruit It is 40% addition deionized water by pulp volume, while adding pectase 2.5%, in 30 DEG C of conditions after stirring and evenly mixing after slurry Lower standing 40min;95% ethanol solution is added in supernatant liquor after standing, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, Ultrasonic extraction 15min centrifuges 10min under 4000rpm/min rotating speeds;Centrifugation gained supernatant liquor is concentrated into half flowing pulpous state After object, by slurry with 1:20 volume ratios are dissolved in deionized water, agitated, shake up, after miillpore filter device degerming, obtain black fruit Gland rib Sorbus alnifloria extract.

Further, the Extract of Euphorbiae, Yunnan Lindley Butterflybush Herb extract, Radix Ampelopsis extract, licorice and the Qin The specific extraction step of Macrophylla extract is:Dry moleplant seed, Yunnan Lindley Butterflybush Herb, radix ampelopsis, Radix Glycyrrhizae and bark of ash is taken to crushed 200 Mesh sieve, be added 30 times of weight 90% mass concentration ethanol solution, impregnate 75h, filtering, under 4000rpm/min rotating speeds from Heart 12min;Supernatant, concentrated by rotary evaporation to a concentration of 0.8g/ml, concentrate is taken to be carried to get moleplant seed through miillpore filter device degerming Take object, Yunnan Lindley Butterflybush Herb extract, Radix Ampelopsis extract, licorice and Radix Gentianae Macrophyllae extract.

A kind of preparation method of high anti-microbial property adhesive of medical, which is characterized in that include the following steps:

Sodium alginate, lignin, tannic acid, stabilizer are added according to number ratio in sterile water, are heated to by step 1 100 DEG C, stirring and dissolving 150min is cooled to room temperature, obtains water solution A;

Step 2 presses poly- (isobutyl alpha-cyanoacrylate-alpha-cyanoacrylate monooctyl ester), polyurethane, polyisoprene According to number ratio in Seabuckthorm Seed Oil, 80 DEG C of stirring 75min are heated to, is cooled to room temperature, obtains Seabuckthorm Seed Oil solution B;

Above-mentioned water solution A and Seabuckthorm Seed Oil solution B are uniformly mixed by step 3, and are added according to number ratio and are efficiently resisted Bacterium component and formaldehyde inhibitor stir 4h;

Step 4 handles step 3 products therefrom through filtration sterilization, dispenses, seals, packing and cured up to high anti-microbial property Use adhesive.

Since it has the advantages that a series of uniquenesses, i.e., singly it is why a-cyanoacrylate class medical adhesive, which quickly grows, Component, it is solvent-free, do not need additional catalyst etc., at normal temperatures can quick-binding.And bonding range is wide, intensity is high, Has the characteristics that instantaneous solidification, it is often more important that such medical adhesive has no toxic side effect substantially to organisms such as skins.Chemical constitution Particularity determine its advantageous property in terms of bonding, the molecular structure of a-cyanoacrylate class compound Alpha -carbon atom attracts the very competent of electronics in CNCH2CCOOR, when chemistry will occur immediately for the anion for touching denier Reaction.Form have on the basic substance gal4 amino acid chain of organism it is a large amount of be in electronegativity group-NH2 and-COOH, when connecing Contacting can react rapidly when a-cyanoacrylate, and the principle is but also medical adhesive is widely used in clinic.Alpha-cyano third The type and size of influence and alkyl of the olefin(e) acid ester for tissue have much relations.Ester group carbochain is longer under normal circumstances, polymerization Reaction rate is slower, reduces to the irritation of tissue, glue-line flexibility improves.The present invention selects poly- (alpha-cyanoacrylate isobutyl Ester-alpha-cyanoacrylate monooctyl ester) as the primary raw material in system, it is to be prepared using emulsion process, itself has Good biocompatibility and excellent anti-microbial property.A-cyanoacrylate class itself is sterile, for golden yellow and white grapes Coccus, bacillus tetragenus, hay bacillus etc. all have height bacteriostasis.

Adhesive for polyurethane is considered as one of the most promising biomedical material solved these problems, polyurethane adhesive Glutinous agent has each excellent shear strength and impact property, is suitable for various structural bonding fields, and have each excellent Flexibility.Adhesive for polyurethane is because of wherein very strong containing polarized, chemical activity is very high isocyanates and carbamic acid Ester group, so it suffers from excellent chemical adhesion with many materials containing active hydrogen.Polyurethane with by jointing material Between the hydrogen bond action that generates molcohesion can be made to enhance, to keep bonding more secured.In addition, adhesive for polyurethane also has There are the characteristics such as good toughness, controllability, adhesion technique simplicity, splendid resistance to low temperature and excellent stability.Cause Select appropriate addition polyurethane compositions to achieve the purpose that the toughness and adhesion strength that improve final products in this present invention, together When, because polyurethane has good biocompatibility to be easier to carry out good combination with anti-biotic material and merge, to enhance The purpose of integral material anti-microbial property.

Polyisoprene is the main rubber constituent of Heveatex, itself degree of purity is high, safe to the human body, has antibacterial Performance is suitable for medicine, health etc. and requires latex product safety and comprehensive performance high field.Cyanoacrylate with And the modified use of common addition of polyurethane, the stability of polyisoprene glue class product can be greatly improved, while can have again Polymerism, caking property, the various mechanical performances of flexibility and the biocompatibility of improvement cyanoacrylate of effect etc. are comprehensive Performance, final medical adhesive class product can be more in line with all requirements of clinical medical glue.

Optically catalytic TiO 2 antiseptic and silver-series antibacterial agent belong to inorganic antiseptic, have safety, lasting, broad-spectrum etc. Characteristic is widely used in recent years.Nano-titanium dioxide, also known as nanometer titanium dioxide.For size, usually produce The size of the fine particles of raw physicochemical properties significant changes is at 100 nanometers hereinafter, its appearance is fluffy white powder.Have Uvioresistant, antibacterial, self-cleaning, anti-aging effect, can be used for cosmetics, functional fibre, plastics, ink, coating, paint, essence The fields such as fine ceramic.Under action of ultraviolet radiation, pernicious sea can thoroughly be killed with the superfine TiO2 of 0.1mg/cm3 concentration and drawn and attenuated Born of the same parents, and increasing with superoxide dismutase (SOD) additive amount, the efficiency that cancer cell is killed in TiO2 photocatalysis also improve; With TiO2 photochemical catalytic oxidation advanced treating tap water, the bacterial population in water can be greatly reduced, without mutagenesis after drinking, reached The standard of safe drinking water.Nano TiO 2 is added in coating, and can to produce sterilization, antifouling, deodorization, self-cleaning antibacterial antifouling Coating can be applied to the place that the bacteriums such as hospital ward, operating room and family bathroom space are intensive, easily breed, and can effectively kill big The harmful bacterias such as enterobacteria, yellow glucose fungus, prevent from infecting.Therefore, nano TiO 2 can purify air, have deodorization functions. Nano silver can kill more than 600 kinds of germ, and can achieve the effect that 99% or more.Ag-carried nanometer titanium dioxide solution is great Improve deficiency of the nano-titanium dioxide in terms of sterilizing.Ag-carried nanometer titanium dioxide is a kind of and its excellent anti-biotic material. Ag-carried nanometer titanium dioxide antiseptic not only has antibiotic property, moreover it is possible to as uvioresistant, age resister.The antiseptic is added to obtain It obtains good anti-microbial property and there is antimicrobial long-acting.

Chlorhexidine acetate is also known as acetic acid chlorhexidine, is a kind of biguanides disinfectant, by with high degree of symmetry linear chain structure Chlorohexidene combines two acetic acid molecules to form.Chlorhexidine acetate is cationic surfactant preservative, has has a broad antifungal spectrum, is resisted Bacterium acts on stronger feature.Chlorhexidine acetate there is apparent compatibility, mechanism of action to be bonded to the thin of bacterium bacterium After birth surface, change permeability of the membrane, cause intracellular matter to flow out, cytoplasm precipitation and agglutination, inhibit cell growth to Kill cell.Numerous studies both domestic and external show chlorhexidine acetate to Escherichia coli, staphylococcus aureus, streptococcus mutans, Actinomyces, many Gram-positives such as Pseudomonas aeruginosa and negative bacteria and fungi such as Candida albicans are made with very strong inhibition With.Montmorillonite is also known as " bentonite ", and being one kind having 2:The natural mineral matter of 1 type phyllosilicate crystal structure, each unit Structure cell leans on public oxygen atom to connect, this four sides therebetween by carrying one layer of alumina octahedral secretly among two oxygen-octahedrons Body and octahedral close-packed structure make it have the crystal arrangement of high-sequential, and interfloor distance is about 1nm or so.Interlayer It is the commutative inorganic cations such as Na+, Ca2+ of hydration.Si4+ in montmorillonite tetrahedron is often substituted by Al3+, in octahedra Al3+ often by replacements such as Mg2+, Fe3+, Fe2+, Ni2+, Li+, to make interlayer generate weak negative electrical charge, superfluous negative electrical charge By cation balances such as the Na+, Ca2+ and the Mg2+ that are free on interlayer, therefore it is easy and alkyl quaternary ammonium salts or other organic cations It swaps reaction and generates organo montmorillonite.Using this property, montmorillonite can combine shape with antibacterials, large biological molecule etc. Functional composite material prepares the nanocomposite with control medicament slow release effect.

Chlorhexidine acetate-montmorillonite-based nano antibiotic complex of the present invention is a kind of novel nano antibacterials, Neng Gouyou The antibiotic property of effect enhancing chlorhexidine acetate and the slow release for ensureing anti-biotic material, greatly improve to Escherichia coli, golden yellow grape The inhibition of the Gram-positives such as coccus, streptococcus mutans, Pseudomonas aeruginosa and negative bacteria and fungi such as Candida albicans.Together When, chlorhexidine acetate-montmorillonite and the common addition of polyurethane make the anti-biotic material of preparation with long-acting, stable, safe and reliable And excellent mechanical performances, and this lower cost for material, more easily processing.

Graphene exists because of its good conductivity, heat conductivility, light transmission, biocompatibility and mechanical strength etc. Electronic device, biology and medicine and other fields cause the extensive concern of researcher.Graphene oxide (grapheneoxide) is The important derivatives of graphene, its agent structure and graphene are essentially identical, the difference is that the two dimension in monatomic arrangement is empty Between the basal plane that infinitely extends be connected with epoxy bond and hydroxyl in both sides up and down, be connected with the functional groups such as carboxyl in edge, it and graphene Relationship be similar to functionalization carbon nanotube and carbon nanotube, not only respectively had characteristic but also had more general character.Graphene oxide is because of it The abundant functional group of higher specific surface area and surface, in the compatibility to cell, and the enhancing to polymer nano material It has a wide range of applications in terms of anti-microbial property.Domestic and foreign scholars are mainly applied to electronics to the application of graphene oxide at present The fields such as device, reinforcing material, bio-medical.

The medical material and wound compatibility prepared using alginate as raw material is good, and has the characteristics that quick-acting haemostatic powder, Human tissue organ is can be used for repair and there is anti-microbial property.Sodium alginate chemical molecular formula is (C6H706Na) n, is one Kind natural polysaecharides carbohydrate, physicochemical properties are:Tasteless white or faint yellow unsetting powder, soluble easily in water, suction It is moist it is strong, insoluble in organic solvents such as alcohol, chloroforms, have bioadhesive, biocompatibility and biodegradable etc. special Point.The base material of drug is can be used as to use in medicine and biotechnology field, sodium alginate.Sodium alginate early in 1938 just Take in United States Pharmacopeia.Alginic acid is in 1963 annual income British Pharmacopoeias.Alginic acid is not soluble in water, but can expand into the water.Therefore, Traditionally, sodium alginate is used as the adhesive of tablet, while sodium alginate also has unique advantage, sodium alginate in terms of thickening Good mobility can prevent the viscosity during effect product sterilization from declining phenomenon.Meanwhile sodium alginate can function as system In stabilizer, the storage of more convenient product and transport.

Sinopimelodendron kwangsiense is that Euphorbiaceae is also known as Mi Bi, monkey fruit, mountain Chinese chestnut, acer fabri;Light, the warm more moistures of happiness are waited, are resisted cold, leaf The raw sprig top of collection, oval or long round shape ellipse, full edge, panicle, basidixed, the same sequence of flower unisexuality, male flower is smaller, fruit Drupe shape, single spherical or double spherical shapes.Cleidiocarpon arbor, fruit are close in the ovoid or double spherical shapes, style base beak, seed of deflection Spherical shape, 5-11 month flowering fruit bearing stages.It is distributed in Guizhou In China south, the Guangxi northwestward, western part and the west and south, southeastern Yunnan.It is born in In the hillside or cheuch evergreen forest of 150-1000 meters of mountainous regions of height above sea level or limestone, Vietnam and Burma also have.Sinopimelodendron kwangsiense is few kind Belong to, China's only this one kind, is a kind of timber Trees of grain and oil dual-purpose.Seed oil content 33-39%, protein 15-18%, starch 21-40%, sugar 2.5-12%.Containing ingredients such as Kaempferol, cyanidenons for staphylococcus, large intestine in butterfly berry extract The various bacterias such as bacillus, bacillus subtilis all have efficient inhibiting effect, antibacterial activity extremely strong.Meanwhile sinopimelodendron kwangsiense extracts Adjacent light yl benzoic acid methyl esters has local irritant effect in object, can promote local blood ring, there is detumescence, anti-inflammatory, analgesic to make With different caye the beautiful jade class compound of tetrahydrochysene has antifungal activity, it should be noted that contain more neighbour in butterfly berry extract Phthalates itself are exactly good plasticizer, the plasticizer that can be directly used as in system of the present invention so that product Flexibility enhances and reduces again while being easily worked the usage amount of plasticising agent aid, reduces cost.

Black Box Tracing also known as the wild cherry certain kind of berries, the not old certain kind of berries, the rose family, gland Aronia, perennial machaka.It originates in North America northeast, Baltic Sea bank to pacific rim are distributed.Include procyanidine, anthocyanin, Quercetin in fruit The equal bioactive ingredients such as polyphenol compounds and organic acid, triterpenes, phytosterin compound, wherein polyphenol compound Total amount is above the berries such as blueberry, cowberry and Cranberry up to 2.5%~3.5%.Black Box Tracing extract is to large intestine bar Bacterium, staphylococcus aureus have the function of efficient antibacterial activity while having anti-oxidant and anti-inflammatory again, can also be used as anti- Rotten agent uses.

Sweet wormwood is the aerial part of feverfew artemisia annua, annual herb plant.The main source of antimalarial artemisinine. It is as follows that sweet wormwood includes chemical composition:Sesquiterpenoids lactone:Qinghaosu series compound, such as qinghaosu, sweet wormwood first, second, sweet wormwood Lactone etc..Flavonoids:Campherol (Kaempferol), Quercetin.Active ingredient in sweet wormwood have efficient anastalsis and Significant anti-microbial property.

Contain a large amount of Flavonoid substances in citrus peel, there is antibacterial anti-inflammatory, antiallergy, analgesia, antiviral, antioxygen Change, antitumaous effect, is the fabulous raw material as drug, for Escherichia coli, staphylococcus aureus and bud pole bacterium Equal common bacterias have excellent antibacterial activity.Citrus peel of the present invention be the orange peel for originating from the western Hunan, sour shaddock ped or Person's fragrant citrus pericarp.

Mulberry tree is a kind of perennial xylophyta, and mulberry tree is right always as the main food source of silkworm for a long time The development of silk industry play the role of it is vital, the correlative study of mulberry tree also develop all around promotion silk industry and Carry out.However, in addition to the food source as silkworm, mulberry tree also has a lot of other important applications, Sang Gen, mulberry skin, mulberry leaf etc. Can all it be used as medicine.Contain a variety of rare flavones ingredients in mulberry skin:Mulberrin, mulberrochromene, cyclomulberrin, sanggenon A~P and contain mulberry Furans A, B, C, K, N, 0, M, P, Q, birch skin acid, mulberry polysaccharide and Coumarins ingredient, the root bark of white mulberry have staphylococcus aureus Stronger inhibiting effect;Also there is slight inhibiting effect to typhoid bacillus and shigella flexneri.Mulberry skin furans A is to golden yellow Portugal Grape coccus, mycobacterium have stronger bacteriostatic activity.Cyclomorusin also has antifungic action.

It is flavone compound, anthraquinone analog compound to have the ingredient of bacteriostatic activity in phllostachys pubescens leaf ext.Mainly pass through work Cell membrane for microorganism is to reach fungistatic effect.Isoflavones in phllostachys pubescens leaf ext can significantly inhibit the catalysis of junket ammonia enzyme Activity interrupts oxidation of melanin process, inhibits the generation and formation of melanin, to prevent the row of scar at;Isoflavones has Anti-oxidant, enhancing immunity of organisms.Contain a large amount of flavone compound and bioactive polysaccharide in Moso Bamboo Leaves and other are effective Ingredient, such as phenolic acid compound, anthraquinone analog compound, terpene lactone, extraordinary amino acid and active peptide, manganese, zinc, selenium substance. Function factor contained in Moso Bamboo Leaves is mainly flavone glycoside and Coumarins lactone.Phllostachys pubescens leaf ext has excellent suppression Many biological actions such as bacterium, Green Tea Extract, anti-oxidant.The mechanism of action of phllostachys pubescens leaf ext preservative, actually mainly It is to have an impact to enzymatic activity or to the hereditary particle structure of cellular plasm part.And phllostachys pubescens leaf ext is even more a kind of day Right bacteriostatic preservative, the one of which active component as the present invention can effectively play antisepsis, without especially adding Add for the harmful chemicals preservative ingredient of skin.

Moleplant seed, Chinese medicine name.For the dry mature seed of euphorbia plant Euphorbia lathyris.Contain diterpene alcohol and ester in moleplant seed Class compound, phytosterin compound, coumarin kind compound, flavone compound, volatile oil compound, fatty oil composition, Other class compounds.Have the function of the antibacterial anti-inflammatory of strength, ease pain detumescence, astringing to arrest bleeding.

Yunnan Lindley Butterflybush Herb is the plant that Scrophulariaceae Lindley Butterflybush Herb belongs to, and is the endemic plant in China.The ground such as Yunnan are distributed in, are grown It is how raw in mountainous region border and hillside bushes in 1,000 meter to 2,500 meters of area of height above sea level.What Genus Buddleja L contained Bioactive ingredients are more, including flavonoids, Phenylpropanoid Glycosides phenolic glycoside, terpene, saponin(e, lignanoid, sterol, long-chain fatty acid ester and life Alkaloids etc..Yunnan Lindley Butterflybush Herb has the function of antibacterial anti-inflammatory, sedation-analgesia.

Radix ampelopsis also known as mountainous region melon, wild sweet potato, V. amurensis seedling, Bai Gen, five pawl rattans etc., are the drying of vitaceae radix ampelopsis Root tuber.It is distributed in the ground such as North China, northeast, East China, Central-South and Shaanxi, Ningxia, Sichuan.Spring, the excavation of two season of autumn remove silt and thin Root is cut into vertical valve or inclined tab, dries.Radix Ampelopsis extract has clearing heat and detoxicating, dispersing swelling and dissipating binds, myogenic pain relieving, anti-inflammatory antibacterial work( Effect.

Radix Glycyrrhizae alias state is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, sweet tea root.Pulse family, Glycyrrhiza perennial herb, root and root-like stock It is sturdy, it is a kind of help Chinese herbal medicine.To human body, a kind of medicine, medicinal part are root and rhizomes well, and Medicinal Materials Characters root is in cylinder Shape, 25~100 centimetres long, 0.6~3.5 centimetre of diameter.Crust is elastic to differ, surface rufous or taupe brown.Rhizome is in cylinder There is bud scar on shape, surface, has marrow in the middle part of section.Gas is micro-, sweet and special.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc.. Happiness is dark moist, the low dry climate of the long temperature of sunshine.Radix Glycyrrhizae is grown in arid, semiarid desert steppe, desert edge more With loess hill area, root and root-like stock hyoscine.Researcher has found that the active ingredient in its Radix Glycyrrhizae is flavone compound example Such as liquiritin, glycyrrhizin etc., triterpene substance such as enoxolone, glycyrrhizin etc. and some polysaccharose substances.Radix Glycyrrhizae is extracted Inhibit the activity of tyrosinase while object uvioresistant, moreover it is possible to effective antibacterial and the problems such as improve inflammation, while can be with It is effectively promoted skin wound healing and improves scar situation.

Bark of ash is Gentianaceae herbaceos perennial, is to control one of main ingredients of diseases such as rheumatic arthritis.In Qinghai especially with Huang The bark of ash quality of south production is best.It is important one of the traditional Chinese medicine of China, first recorded in"Sheng Nong's herbal classic".Bark of ash has wind-dispelling, It is clearing heat and detoxicating, it is anti-inflammatory, it is antibacterial, the effects that analgesia.The main component of its extract is iridoid glycosides, triterpenes, sterols And carbohydrate, such compound all have good anti-microbial property, while it being effectively promoted wound healing and the growth of skin again.

Tannic acid belongs to typical glucose acyl compound, and it is a series of unique that the structure of polyphenol hydroxyl imparts it Chemical characteristic and physiological activity make its physical chemistry behavior change as being combined with protein, alkaloid, polysaccharide;It can be with Complexing and electrostatic interaction occur for various metals ion;Activity with reproducibility and capture free radical;With amphiphilic structure and all More derivative reaction activity etc..Multiple ortho position phenolic hydroxyl structures of tannic acid can be used as a kind of multidentate ligand and metal ion Complex reaction occurs.Two adjacent phenolic hydroxyl groups can form stable five-membered ring with metal ion with the form of negative oxygen ion and chelate Although object, the third phenolic hydroxyl group in pyrogallol structure are not engaged in complexing, but can promote other two phenolic hydroxyl group from Solution, to promote formation and the stabilization of complex compound.Ortho position phenolic hydroxyl group in the pyrogallol structure of tannic acid is easily oxidized At quinones structure, when having enzyme, sufficient moisture and higher ph (such as pH > 3.5), oxidation reaction carries out faster, to Consume the oxygen in environment.Phenol type structure is excellent hydrogen donor, is had obviously to free radicals such as negative oxygen ion and hydroxyl radical free radicals Inhibiting effect, and play the protective effect to biological tissue.Tannic acid traps certainly due to containing phenolic hydroxyl group with good By base function, it can be used as antioxidant.Such as sulfur dioxide is replaced to make grape wine antioxidant with food-grade tannic acid.

Due to containing unique polyphenol hydroxyl structure in tannic acid, can be combined with large biological molecules such as protein-polysaccharides Complexing can occur with metal ion, include catechol based structures in this polyphenol hydroxyl structure, so having well also Originality, convergence and antibiotic property are clinically used for treatment local hemorrhage, and tannic acid can be used for synthesizing gallic acid and Pyrogallol is (burnt Property gallic acid, pyrogallol).Tannic acid is the primary raw material for manufacturing Trimethoprim on medical industry.

Lignin is the second biomass resource that plant kingdom is only second to cellulose, contains about 15-30%'s in wood Lignin contains the lignin of about 12%-20% in annual plant;Lignin in nature as uniquely capable of providing virtue The biomass resource of perfume base group, lignin but can be biodegradable.There are a variety of functional groups for lignin, can directly be used as solidification Agent, lignin, which is added in resin, prepares adhesive with good ageing-resistant performance and excellent anti-microbial property.

Seabuckthorm Seed Oil is saturating to brownish red by the brown color that seabuckthorn seeds are obtained by supercritical extract or subcritical low-temperature extraction Bright oily liquids integrates the highly concentrated object of Effective Compositions of Seabuckthorn.Include flavones, organic acid, alkaloid, sterols, three The 140 multiple biological activities ingredient such as terpenes and various vitamins.Seabuckthorm Seed Oil as medicinal raw material there is apparent biology to make With, it is anti-infective it is strong, promote that healing is fast, there have to tonsillitis, stomatitis, skin inflammation, Gynecological cervical inflammation etc. to be good and steady Fixed curative effect.Seabuckthorm Seed Oil is the complex of multivitamin and bioactive substance.It can nourishes rough skin, promotion new old generation It thanks, antiallergy, antibacterial anti-inflammatory, promotes re-epithelilization, have repair to skin, the acidic environment of skin can be kept, have There is stronger permeability, thus is also the important source material of beauty and skin care.Total seabuckthorn flavone in sea-buckthorn can Direct Acquisition super oxygen from By base and hydroxy radical, Ve, Vc superoxide dismutase (SOD) have the function of anti-oxidant and eliminate free radical on cell membrane, Effective delaying human body caducity.The VC contents of sea-buckthorn occupy one and cut fruit, first of vegetables, are known as " king of VC ".And VC is exactly one kind Natural internal whitening agent can effectively inhibit the deposition of abnormal pigment and the activity of tyrosinase on skin, and help DOPA The reduction of pigment is formed to reduce melanin, effectively net white muscle skin.Rich in VE, carrotene, carotenoid, β-in sea-buckthorn Sitosterol, unsaturated fatty acid etc. can inhibit subcutaneous tissue inflammation, the anti-inflammatory effect at enhancing inflammation center, hence it is evident that promote ulcer Healing.

And have sulfonyl and usually by sulphur and the connection of two carbon atoms (such as with two alkyl or a simple divalent Base) a kind of organic compound for being characterized, usually crystalloid stable compound.Sulfone is often produced by sulfide oxidation, intermediate product For sulfoxide.The stabilizer that the present invention selects uses the composition of sulfone compound, and sulfone compound is to many Gram-positives It is all very effective antiseptic with negative bacteria.But because the toxicity problem of various sulfone compounds influences it in each neck The application in domain.The sulfone compound composition that the present invention selects is the innocuous substance haveing excellent performance, while containing cyanogen in addition Base acrylate substance and polyurethane can effectively improve the various mechanical performances of product.3,3'Diamino -4,4'- Dihydroxydiphenylsulisomer itself is nontoxic, can greatly enhance the heat resistance of product and have good thermal stability;Wherein dimethyl Sulfolane boiling point is high, and thermal stability is good, non-corrosive, can also improve product while stability can be improved after addition system Viscosity and the mechanical performances such as flexibility.

Advantageous effect

As a result of above technical scheme, the present invention has the advantages that:

1, the high anti-microbial property adhesive of medical of the present invention includes that special efficacy is received by testing the high-efficiency antimicrobial component of selection repeatedly 5 parts of nano antibacterial component, 12-18 parts of natural antibacterial components, the special of three big antibacterial system of Chinese medicine antibacterial component 5-10 parts composition resist Entire product is long-acting, efficient anti-microbial property comprehensively to improve for bacterium component, while improving the synthesis of adhesive of medical of the present invention Performance substantially reduces the risk of user.

Wherein, special efficacy nano-antibacterial component is by Ag-carried nanometer titanium dioxide, chlorhexidine acetate-montmorillonite and graphene oxide It mixes, the Ag-carried nanometer titanium dioxide that the present invention selects fully combines the advantage and nanometer material of two kinds of inorganic antiseptics Expect distinctive performance, at the same overcome again existing inorganic antibacterial material titanic oxide electronic to easily with hole-recombination and carry ag material silver Discharge fast and easy to change deficiency;Chlorhexidine acetate-montmorillonite-based nano antibiotic complex is a kind of novel nano antibacterials, energy The antibiotic property of enough effectively enhancing chlorhexidine acetates and the slow release for ensureing anti-biotic material;Graphene oxide is because of its higher specific surface , there are considerable advantage in product and the abundant functional group in surface in the compatibility and anti-microbial property to cell.Three kinds of special efficacys it is anti- Bacterium material mutually cooperates with the long-term effect of the anti-microbial property of the wide spectrum that product can be effectively ensured, safety and antibacterial.

In addition, montmorillonite and the addition of graphene oxide can effectively improve poly- (isobutyl alpha-cyanoacrylate-α- Octyl 2-cyanoacrylate) and polyurethane material mechanical property, play effective humidification.Meanwhile chlorhexidine acetate-Meng Tuo Common be added of soil and polyurethane makes the anti-biotic material of preparation have long-acting, stable, safe and reliable and excellent mechanical performances, and this Kind lower cost for material is easier to process.

2, the natural antibacterial components that the high anti-microbial property adhesive of medical of the present invention is selected include 2 parts of butterfly berry extract, it is black 2 parts of fruit gland rib Sorbus alnifloria extract, 3 parts of Artemisinin, 2 parts of mulberry bark extract, 2 parts of citrus peel extract and Moso Bamboo Leaves 2 parts of extract, containing ingredients such as Kaempferol, cyanidenons for staphylococcus, Escherichia coli, withered grass bud in butterfly berry extract The various bacterias such as spore bacillus all have efficient inhibiting effect, antibacterial activity extremely strong.Meanwhile adjacent light base benzene in butterfly berry extract Methyl formate has local irritant effect, can promote local blood ring, has detumescence, anti-inflammatory, analgesic effect, different caye the beautiful jade of tetrahydrochysene Class compound has antifungal activity.Black Box Tracing extract includes the Polyphenols such as procyanidine, anthocyanin, Quercetin Closing object has efficient antibacterial activity.Sesquiterpenoids lactone and Flavone content in Artemisinin is high, has height The anastalsis of effect and significant anti-microbial property.Make with high-efficiency antimicrobial anti-inflammatory containing a large amount of Flavonoid substances in citrus peel With.Mulberrin, mulberrochromene in mulberry bark extract, cyclomulberrin, the even more natural high-efficiency antimicrobial object such as sanggenon, mulberry furans Matter.Flavone glycoside and Coumarins lactone all have excellent antibacterial, Green Tea Extract, anti-oxidant etc. many in phllostachys pubescens leaf ext Biological action.The present invention fully combines the active ingredient of six kinds of natural plants and fruit, makees playing long-acting, high-efficiency antimicrobial With while, it is more preferable for human compatibility, and safe without toxic side effect.

It should be noted simultaneously that Black Box Tracing extract and phllostachys pubescens leaf ext are even more a kind of natural antibacterial anti- Rotten agent, the active component as the present invention can effectively play antisepsis, while chlorhexidine acetate is cationic Active preservative is equivalent in the system internal build of the present invention new preservative system of one tripartite, without especially addition pair In the harmful preservative ingredient of skin.

3, the Chinese medicine antibacterial component that the high anti-microbial property adhesive of medical of the present invention is selected includes 1 part of Extract of Euphorbiae, cloud 1 part of 2 parts of southern Lindley Butterflybush Herb extract, 2 parts of Radix Ampelopsis extract, 2 parts of licorice and Radix Gentianae Macrophyllae extract.In Extract of Euphorbiae It is anti-with strength containing diterpene alcohol and ester type compound, phytosterin compound, coumarin kind compound, flavone compound Bacterium anti-inflammatory, analgesia detumescence, the effect of astringing to arrest bleeding.The bioactive ingredients that Yunnan Genus Buddleja L contains are more, including Huang Ketone, Phenylpropanoid Glycosides phenolic glycoside, terpene, saponin(e, lignanoid and alkaloid etc., have the function of antibacterial anti-inflammatory, sedation-analgesia.Radix ampelopsis carries Take object have clearing heat and detoxicating, dispersing swelling and dissipating binds, myogenic pain relieving, it is anti-inflammatory antibacterial the effect of.Contain liquiritin, Radix Glycyrrhizae in licorice Element and polysaccharose substance can effective antibacterial and the problems such as improve inflammation, while can also be that being effectively promoted skin wound is cured Close and improve scar situation.The effects that bark of ash has wind-dispelling, clearing heat and detoxicating, anti-inflammatory antibacterial, analgesia.Its extract it is main at It is that iridoid glycosides, triterpenes, sterols and carbohydrate all have good anti-microbial property, while being effectively promoted wound again to divide The growth of healing and skin.While the present invention fully combines the main antibacterial action in five kinds in medicinal substances, and make full use of Extract of Euphorbiae anti-inflammatory analgesic, anastalsis;The anti-inflammatory of Yunnan Lindley Butterflybush Herb extract, analgesic activity;Radix Ampelopsis extract heat-clearing Removing toxic substances, dispersing swelling and dissipating binds, myogenic pain relieving effect;In licorice promote skin wound healing and improve scar situation effect with And bark of ash has the function of the growth that wind-dispelling promotes wound healing and skin.Chinese medicine antibacterial component is in auxiliary special efficacy nano-antibacterial group Point and natural antibacterial components while collectively form three big antibacterial systems, taken into account anti-inflammatory, eased pain, wind-dispelling promotes wound healing With the effect of skin growth so that product of the present invention can become be more suitable for that clinical operation uses full-featured medical viscous Mixture.The present invention selects natural antibacterial components and Chinese medicine antibacterial component to be combined, the advantage of more prominent product, because biology is thoroughly Skin accelerating agent derives from plant extracts, has good biocompatibility, and will not cause to damage to skin, has safety Property.

4, the other compositions that the high anti-microbial property adhesive of medical of the present invention is selected all have efficient antibacterial functions, become An entire antimicrobial product essential component part.The effect of a variety of antibacterial components, is like nature itself, this hair is prepared Bright high anti-microbial property adhesive of medical.Poly- (isobutyl alpha-cyanoacrylate-alpha-cyanoacrylate monooctyl ester) is as the master in system Raw material is wanted, is to be prepared using emulsion process, itself has good biocompatibility and excellent anti-microbial property.α- Cyanoacrylate itself is sterile, and all having height for golden yellow and staphylococcus albus, bacillus tetragenus, hay bacillus etc. presses down Bacterium acts on.Polyisoprene is the main rubber constituent of Heveatex, itself degree of purity is high, safe to the human body, has antibacterial Performance polyurethane has good biocompatibility to be easier to carry out good combination with anti-biotic material and merge, whole to enhance Body material anti-microbial property.

Due to containing unique polyphenol hydroxyl structure in tannic acid, can be combined with large biological molecules such as protein-polysaccharides Complexing can occur with metal ion, include catechol based structures in this polyphenol hydroxyl structure, so having well also Originality, convergence and antibiotic property are clinically used for treatment local hemorrhage, and tannic acid can be used for synthesizing gallic acid and Pyrogallol is (burnt Property gallic acid, pyrogallol).Tannic acid is the primary raw material for manufacturing Trimethoprim on medical industry.

There are a variety of functional groups for lignin, can directly be used as curing agent, lignin, which is added in resin, prepares adhesive tool There are good ageing-resistant performance and excellent anti-microbial property.

Seabuckthorm Seed Oil is the complex of multivitamin and bioactive substance.It can nourishes rough skin, boost metabolism, Antiallergy, antibacterial anti-inflammatory, promote re-epithelilization, have repair to skin, the acidic environment of skin can be kept, have compared with Strong permeability.

Sodium alginate is a kind of natural polysaecharides carbohydrate, the medical material and wound prepared using alginate as raw material Mouth compatibility is good, and has the characteristics that quick-acting haemostatic powder, can be used for human tissue organ and repairs and have anti-microbial property.

The stabilizer that the present invention selects uses the composition of sulfone compound, and sulfone compound is to many Gram-positives It is all very effective antiseptic with negative bacteria.

The formaldehyde inhibitor that the present invention selects is benzoguanamine and hydantoins, and benzoguanamine and hydantoins are inherently With broad spectrum antibiotic activity.

In conclusion whole raw materials itself that the present invention selects all have anti-microbial property, increase special efficacy again on this basis The anti-microbial property of nano-antibacterial component, natural antibacterial components, three big antibacterial system General Promotion product of Chinese medicine antibacterial component, collaboration Necessarily so that high anti-microbial property adhesive of medical prepared by the present invention has the more efficient antibiotic property of strength under synergistic effect Can, while comprehensive performance is also more complete.

5, the formaldehyde inhibitor that the bright high anti-microbial property adhesive of medical of the present invention selects is pressed for benzoguanamine and hydantoins According to weight fraction 1:4 are composed, and benzoguanamine and hydantoins inherently have broad spectrum antibiotic activity, can be in two components Coordinated inhibits that a power-assisted can be provided for the antibiotic property of the high anti-microbial property adhesive of medical of the present invention while formaldehyde.It needs It is further noted that inherently a kind of effective formaldehyde of the unique polyphenol hydroxyl structure of tannic acid in the present invention inhibits Agent, Seabuckthorm Seed Oil contain a variety of active ingredients, and triterpene alkenes therein are also effective formaldehyde inhibitor, described in the present invention Natural antibacterial components and Chinese medicine antibacterial component in many kinds of substance in contain triterpenes, sterol substance, substance of this kind It may be used as formaldehyde inhibitor.That is, the present invention is equivalent to has had been built up one mutually in the raw material of invention The formaldehyde inhibition system of collaboration, formaldehyde inhibitor, tannic acid, natural antibacterial components and the Chinese medicine antibacterial selected in conjunction with the present invention Many kinds of substance comprehensive function in component is played the role of efficiently inhibiting formaldehyde jointly, also fully demonstrates the medical viscous of the present invention Mixture has extremely low toxicity, and application risk will substantially reduce, and is more suitable for human body use.

The adhesion strength of the high anti-microbial property adhesive of medical of the present invention is all higher than 60N, to the antibacterial of staphylococcus aureus Rate is up to 98.5% or more, can reach 99% to the antibiotic rate of Escherichia coli, substantially increase whole healing efficiency, biofacies Capacitive is high, non-stimulated to wound tissue, reduces sensitization rate, and comprehensive performance is outstanding, meets clinic and is wanted to the application of adhesive of medical It asks, the anti-microbial property by improving adhesive of medical reduces the infection risk of patient to greatest extent, to reach higher healing The guarantee that rate provides.

Specific implementation mode

The present invention is specifically described below by specific embodiment:

Embodiment 1

A kind of high anti-microbial property adhesive of medical, includes the component of following parts by weight:

45 parts of poly- (isobutyl alpha-cyanoacrylate-alpha-cyanoacrylate monooctyl ester), 24 parts of high-efficiency antimicrobial component, polyurethane 2 Part, 20 parts of polyisoprene, 2 parts of sodium alginate, 3 parts of lignin, 7 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, sand Spine seed oily 150 parts, 180 parts of sterile water;High-efficiency antimicrobial component include 5 parts of special efficacy nano-antibacterial component, 12 parts of natural antibacterial components, 5 parts of Chinese medicine antibacterial component;Special efficacy nano-antibacterial component is by Ag-carried nanometer titanium dioxide, chlorhexidine acetate-montmorillonite and oxidation stone Black alkene is 2 according to weight part ratio:2:1 mixes;Natural antibacterial components in parts by weight, including butterfly berry extract 2 parts, 2 parts of Black Box Tracing extract, 3 parts of Artemisinin, 2 parts of mulberry bark extract, 2 parts of citrus peel extract and 2 parts of phllostachys pubescens leaf ext;Chinese medicine antibacterial component in parts by weight, including 1 part of Extract of Euphorbiae, Yunnan Lindley Butterflybush Herb extraction 1 part of 2 parts of object, 2 parts of Radix Ampelopsis extract, 2 parts of licorice and Radix Gentianae Macrophyllae extract.Stabilizer is 3,3'Diamino -4,4'- Dihydroxydiphenylsulisomer and dimethylsulfolane are according to parts by weight 3:1 is composed;Formaldehyde inhibitor is in benzoguanamine and second Uride is according to weight fraction 1:4 are composed.

Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested As a result it is:The adhesion strength of the high anti-microbial property adhesive of medical of the present invention is 62N, and the antibiotic rate to staphylococcus aureus is 98.3% or more, 99% is reached to the antibiotic rate of Escherichia coli.

Embodiment 2

A kind of high anti-microbial property adhesive of medical, includes the component of following parts by weight:

50 parts of poly- (isobutyl alpha-cyanoacrylate-alpha-cyanoacrylate monooctyl ester), 29 parts of high-efficiency antimicrobial component, polyurethane 3 Part, 21 parts of polyisoprene, 3 parts of sodium alginate, 4 parts of lignin, 8 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, sand Spine seed oily 180 parts, 180 parts of sterile water;High-efficiency antimicrobial component include 5 parts of special efficacy nano-antibacterial component, 14 parts of natural antibacterial components, 7 parts of Chinese medicine antibacterial component;Special efficacy nano-antibacterial component is by Ag-carried nanometer titanium dioxide, chlorhexidine acetate-montmorillonite and oxidation stone Black alkene is 2 according to weight part ratio:2:1 mixes;Natural antibacterial components in parts by weight, including butterfly berry extract 2 parts, 2 parts of Black Box Tracing extract, 3 parts of Artemisinin, 2 parts of mulberry bark extract, 2 parts of citrus peel extract and 2 parts of phllostachys pubescens leaf ext;Chinese medicine antibacterial component in parts by weight, including 1 part of Extract of Euphorbiae, Yunnan Lindley Butterflybush Herb extraction 1 part of 2 parts of object, 2 parts of Radix Ampelopsis extract, 2 parts of licorice and Radix Gentianae Macrophyllae extract.Stabilizer is 3,3'Diamino -4,4'- Dihydroxydiphenylsulisomer and dimethylsulfolane are according to parts by weight 3:1 is composed;Formaldehyde inhibitor is in benzoguanamine and second Uride is according to weight fraction 1:4 are composed.

Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested As a result it is:The adhesion strength of the high anti-microbial property adhesive of medical of the present invention is 62.6N, and the antibiotic rate to staphylococcus aureus is 98.5% or more, 99% is reached to the antibiotic rate of Escherichia coli.

Embodiment 3

A kind of high anti-microbial property adhesive of medical, includes the component of following parts by weight:

53 parts of poly- (isobutyl alpha-cyanoacrylate-alpha-cyanoacrylate monooctyl ester), 32 parts of high-efficiency antimicrobial component, polyurethane 4 Part, 23 parts of polyisoprene, 3 parts of sodium alginate, 5 parts of lignin, 9 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, sand Spine seed oily 190 parts, 180 parts of sterile water;High-efficiency antimicrobial component include 5 parts of special efficacy nano-antibacterial component, 16 parts of natural antibacterial components, 9 parts of Chinese medicine antibacterial component;Special efficacy nano-antibacterial component is by Ag-carried nanometer titanium dioxide, chlorhexidine acetate-montmorillonite and oxidation stone Black alkene is 2 according to weight part ratio:2:1 mixes;Natural antibacterial components in parts by weight, including butterfly berry extract 2 parts, 2 parts of Black Box Tracing extract, 3 parts of Artemisinin, 2 parts of mulberry bark extract, 2 parts of citrus peel extract and 2 parts of phllostachys pubescens leaf ext;Chinese medicine antibacterial component in parts by weight, including 1 part of Extract of Euphorbiae, Yunnan Lindley Butterflybush Herb extraction 1 part of 2 parts of object, 2 parts of Radix Ampelopsis extract, 2 parts of licorice and Radix Gentianae Macrophyllae extract.Stabilizer is 3,3'Diamino -4,4'- Dihydroxydiphenylsulisomer and dimethylsulfolane are according to parts by weight 3:1 is composed;Formaldehyde inhibitor is in benzoguanamine and second Uride is according to weight fraction 1:4 are composed.

Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested As a result it is:The adhesion strength of the high anti-microbial property adhesive of medical of the present invention is 63.3N, and the antibiotic rate to staphylococcus aureus is 98.7% or more, 99% is reached to the antibiotic rate of Escherichia coli.

Embodiment 4

A kind of high anti-microbial property adhesive of medical, includes the component of following parts by weight:

55 parts of poly- (isobutyl alpha-cyanoacrylate-alpha-cyanoacrylate monooctyl ester), 36 parts of high-efficiency antimicrobial component, polyurethane 5 Part, 25 parts of polyisoprene, 4 parts of sodium alginate, 6 parts of lignin, 10 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, sand Spine seed oily 200 parts, 180 parts of sterile water;High-efficiency antimicrobial component include 5 parts of special efficacy nano-antibacterial component, 18 parts of natural antibacterial components, 10 parts of Chinese medicine antibacterial component;Special efficacy nano-antibacterial component is by Ag-carried nanometer titanium dioxide, chlorhexidine acetate-montmorillonite and oxidation stone Black alkene is 2 according to weight part ratio:2:1 mixes;Natural antibacterial components in parts by weight, including butterfly berry extract 2 parts, 2 parts of Black Box Tracing extract, 3 parts of Artemisinin, 2 parts of mulberry bark extract, 2 parts of citrus peel extract and 2 parts of phllostachys pubescens leaf ext;Chinese medicine antibacterial component in parts by weight, including 1 part of Extract of Euphorbiae, Yunnan Lindley Butterflybush Herb extraction 1 part of 2 parts of object, 2 parts of Radix Ampelopsis extract, 2 parts of licorice and Radix Gentianae Macrophyllae extract.Stabilizer is 3,3'Diamino -4,4'- Dihydroxydiphenylsulisomer and dimethylsulfolane are according to parts by weight 3:1 is composed;Formaldehyde inhibitor is in benzoguanamine and second Uride is according to weight fraction 1:4 are composed.

Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested As a result it is:The adhesion strength of the high anti-microbial property adhesive of medical of the present invention is 64N, and the antibiotic rate to staphylococcus aureus is 98.9% or more, 99% is reached to the antibiotic rate of Escherichia coli.

In above-mentioned each embodiment

The specific extraction step of butterfly berry extract is:It takes dry sinopimelodendron kwangsiense to crushed 60 mesh sieve, 18 times of weight is added 95% mass concentration ethanol solution, impregnate 80h, filtering, centrifuge 15min under 3000rpm/min rotating speeds;Supernatant is taken, Concentrated by rotary evaporation is to a concentration of 1.5g/ml, and concentrate is through the degerming of miillpore filter device to get butterfly berry extract.

Artemisinin, mulberry bark extract, the preparation method of citrus peel extract and phllostachys pubescens leaf ext are specific Include the following steps:By above-mentioned each raw material through drying, beat powder respectively after sieve with 100 mesh sieve, respectively obtain the powder of each raw material, so After 95% ethanol solution is added, under the conditions of 45 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 35min obtains extracting solution;It will carry It takes liquid filtering to be concentrated under reduced pressure, obtains slurry;By slurry with 1:12 volume ratios are dissolved in deionized water, agitated, shake up, through micro- After the filter membrane device degerming of hole, respectively each raw extract.

The preparation method of Black Box Tracing extract is as follows:It is described to wash away Black Box Tracing table and mud with circulating water Ozone generator is passed through in sterile water and cleans Black Box Tracing again by sand, and pulp crushing is broken into pulp, presses pulp later Volume is 40% addition deionized water, while adding pectase 2.5%, and 40min is stood under the conditions of 30 DEG C after stirring and evenly mixing;It will 95% ethanol solution is added in supernatant liquor after standing, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 15min, 10min is centrifuged under 4000rpm/min rotating speeds;After centrifugation gained supernatant liquor is concentrated into half flowing slurry, by slurry With 1:20 volume ratios are dissolved in deionized water, agitated, shake up, after miillpore filter device degerming, obtain Black Box Tracing extraction Object.

The tool of Extract of Euphorbiae, Yunnan Lindley Butterflybush Herb extract, Radix Ampelopsis extract, licorice and Radix Gentianae Macrophyllae extract Body extraction step is:It takes dry moleplant seed, Yunnan Lindley Butterflybush Herb, radix ampelopsis, Radix Glycyrrhizae and bark of ash to crushed 200 mesh sieve, is added 30 The ethanol solution of 90% mass concentration of times weight, impregnates 75h, and filtering centrifuges 12min under 4000rpm/min rotating speeds;It takes Clear liquid, concentrated by rotary evaporation to a concentration of 0.8g/ml, concentrate is through the degerming of miillpore filter device to get Extract of Euphorbiae, the liquor-saturated fish in Yunnan Careless extract, Radix Ampelopsis extract, licorice and Radix Gentianae Macrophyllae extract.

The preparation method of above-mentioned high anti-microbial property adhesive of medical, includes the following steps:

Sodium alginate, lignin, tannic acid, stabilizer are added according to number ratio in sterile water, are heated to by step 1 100 DEG C, stirring and dissolving 150min is cooled to room temperature, obtains water solution A;

Step 2 presses poly- (isobutyl alpha-cyanoacrylate-alpha-cyanoacrylate monooctyl ester), polyurethane, polyisoprene According to number ratio in Seabuckthorm Seed Oil, 80 DEG C of stirring 75min are heated to, is cooled to room temperature, obtains Seabuckthorm Seed Oil solution B;

Above-mentioned water solution A and Seabuckthorm Seed Oil solution B are uniformly mixed by step 3, and are added according to number ratio and are efficiently resisted Bacterium component and formaldehyde inhibitor stir 4h;

Step 4 handles step 3 products therefrom through filtration sterilization, dispenses, seals, packing and cured up to high anti-microbial property Use adhesive.

Performance test

The adhesion strength of the high anti-microbial property adhesive of medical of the present invention is all higher than 60N, to the antibacterial of staphylococcus aureus Rate is up to 98% or more, can reach 99% to the antibiotic rate of Escherichia coli, greatly reduces the risk of user while improving Whole healing efficiency, good biocompatibility is non-stimulated to wound tissue, comprehensive performance is outstanding, meets clinic to adhesive of medical Application requirement, the anti-microbial property by improving adhesive of medical can reduce the infection risk of patient to greatest extent, to reach The guarantee provided to higher cure rate.

Example the above is only the implementation of the present invention is not intended to limit the scope of the invention, every to utilize this hair Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks Domain is included within the scope of the present invention.

Claims (6)

1. a kind of high anti-microbial property adhesive of medical, which is characterized in that include the component of following parts by weight:Poly- (alpha-cyano third Olefin(e) acid isobutyl ester-alpha-cyanoacrylate monooctyl ester) 45-55 parts, 24-36 parts of high-efficiency antimicrobial component, 2-5 parts of polyurethane, poly- isoamyl two 20-25 parts of alkene, 2-4 parts of sodium alginate, 3-6 parts of lignin, 7-10 parts of tannic acid, 1 part of stabilizer, 1 part of formaldehyde inhibitor, sea-buckthorn 150-200 parts of seed oil, 180 parts of sterile water;

The high-efficiency antimicrobial component includes 5 parts of special efficacy nano-antibacterial component, 12-18 parts of natural antibacterial components, Chinese medicine antibacterial group Divide 5-10 parts;

The special efficacy nano-antibacterial component is pressed by Ag-carried nanometer titanium dioxide, chlorhexidine acetate-montmorillonite and graphene oxide It is 2 according to weight part ratio:2:1 mixes;

The natural antibacterial components in parts by weight, including 2 parts of butterfly berry extract, Black Box Tracing extract 2 Part, 2 parts of 3 parts of Artemisinin, 2 parts of mulberry bark extract, 2 parts of citrus peel extract and phllostachys pubescens leaf ext;

The Chinese medicine antibacterial component in parts by weight, including 1 part of Extract of Euphorbiae, 2 parts of Yunnan Lindley Butterflybush Herb extract, 1 part of 2 parts of Radix Ampelopsis extract, 2 parts of licorice and Radix Gentianae Macrophyllae extract.

2. high anti-microbial property adhesive of medical according to claim 1, it is characterised in that:The stabilizer is 3,3'- two Amino -4,4'Dihydroxydiphenylsulisomer and dimethylsulfolane are according to parts by weight 3:1 is composed;The formaldehyde inhibitor is Benzoguanamine and hydantoins are according to weight fraction 1:4 are composed.

3. high anti-microbial property adhesive of medical according to claim 1 or 2, which is characterized in that the butterfly berry extract For the ethanol extract of sinopimelodendron kwangsiense, specific extraction step is:Dry sinopimelodendron kwangsiense is taken to crushed 60 mesh sieve, 18 times of weight of addition The ethanol solution of 95% mass concentration, impregnates 80h, and filtering centrifuges 15min under 3000rpm/min rotating speeds;Supernatant is taken, is revolved Inspissation is reduced to a concentration of 1.5g/ml, and concentrate is through the degerming of miillpore filter device to get butterfly berry extract.

4. high anti-microbial property adhesive of medical according to claim 3, which is characterized in that the Artemisinin, mulberry skin The preparation method of extract, citrus peel extract and phllostachys pubescens leaf ext specifically includes following steps:By above-mentioned each original Material through drying, beat powder respectively after sieve with 100 mesh sieve, respectively obtain the powder of each raw material, 95% ethanol solution be then added, in water 45 DEG C warm, under the conditions of ultrasonic power 200W, ultrasonic extraction 35min obtains extracting solution;Extracting solution is filtered and is concentrated under reduced pressure, pulpous state is obtained Object;By slurry with 1:12 volume ratios are dissolved in deionized water, agitated, shake up, after miillpore filter device degerming, respectively respectively Raw extract.

5. high anti-microbial property adhesive of medical according to claim 1 or 4, which is characterized in that the black fruit gland rib flower The preparation method of Chinese catalpa extract is as follows:It is described to wash away Black Box Tracing table and silt with circulating water, ozone generator is passed through Black Box Tracing is cleaned in sterile water again, by pulp crushing break into pulp after, by pulp volume be 40% addition go from Sub- water, while pectase 2.5% is added, after stirring and evenly mixing 40min is stood under the conditions of 30 DEG C;Supernatant liquor after standing is added Enter 95% ethanol solution, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 15min, in 4000rpm/min rotating speeds Lower centrifugation 10min;After centrifugation gained supernatant liquor is concentrated into half flowing slurry, by slurry with 1:20 volume ratios are dissolved in It is agitated, shake up, after miillpore filter device degerming in ionized water, obtain Black Box Tracing extract.

6. high anti-microbial property adhesive of medical according to claim 1 and preparation method thereof, which is characterized in that described a thousand pieces of gold The specific extraction step of seed extract, Yunnan Lindley Butterflybush Herb extract, Radix Ampelopsis extract, licorice and Radix Gentianae Macrophyllae extract For:Dry moleplant seed, Yunnan Lindley Butterflybush Herb, radix ampelopsis, Radix Glycyrrhizae and bark of ash is taken to crushed 200 mesh sieve, 30 times of weight of addition The ethanol solution of 90% mass concentration, impregnates 75h, and filtering centrifuges 12min under 4000rpm/min rotating speeds;Supernatant is taken, is revolved Inspissation is reduced to a concentration of 0.8g/ml, and concentrate is extracted through the degerming of miillpore filter device to get Extract of Euphorbiae, Yunnan Lindley Butterflybush Herb Object, Radix Ampelopsis extract, licorice and Radix Gentianae Macrophyllae extract.