CN108635618A - It is a kind of that there is the preparation method for promoting healing and repair function medical adhesive - Google Patents

Abstract

The invention discloses a kind of preparation methods for having and promoting healing and repair function medical adhesive, which is characterized in that includes the component of following parts by weight：25 35 parts of the different monooctyl ester of 20 25 parts of a n-butyl cyanoacrylate, a alpha-cyanoacrylates, 26 parts of phenylethylene thermoplastic elastomer microballoon efficiently promote healing and repair 25 37 parts of component, 24 parts of sodium alginate, 36 parts of Sodium Hyaluronate, 8 10 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizer, 150 220 parts of composite fruit oil ingredient, 200 parts of sterile water.Adhesive of medical of the invention has especially selected a variety of bio-extracts with regeneration function and has been added to three big promotion healings and repairs component to promote healing and improve repairing effect, and adhesion strength is high, good biocompatibility, meets the clinical application requirement to adhesive of medical.

Description

It is a kind of that there is the preparation method for promoting healing and repair function medical adhesive

Technical field

The invention belongs to medical material tech fields, and in particular to it is a kind of have promote healing and repair function it is medical Glue and preparation method thereof.

Background technology

With the progress of medicine, the requirement clinically to surgical technic and auxiliary material effect is higher and higher.Modern medicine Requirement to reduce the pain of patient to the maximum extent, while also more focusing on the reparation situation of post-surgical scars, especially in medicine In beauty and shaping industry, postoperative recovery and beauty are particularly important.Adhesive of medical is one point of medical high polymer Branch, it is bonding object with biological tissue, and human body overwhelming majority tissue, organ can apply adhering technique over the course for the treatment of Substitution part sutures, ligation operation, it is not necessary to anaesthetize；Automatic-falling after wound healing.Compared with conventional method, adhesive of medical Using that can effectively shorten operating time, patient pain's sense is reduced, and can be realized simultaneously quick reparation and guarantee U.S. of wound It sees.

The main direction of studying of adhesive of medical is to improve the adhesion strength of various adhesives at present, however outer at present The bio-medical material applied in section's operation seldom has the effect for being efficiently promoting healing and repairing scar, ugly scar It leaves and brings huge spirit and psychological pressure to patient, it is to solve this to assign medical material to promote healing and repair function The effective ways of problem.The generation of formaldehyde generates bio-tissue secondary during the storage of cyanoacrylate medical adhesive, use Effect, and as the increase of concentration of formaldehyde increases the damage of organism, seriously affected the effect of adhesive of medical and answered With.

Invention content

Based on the above prior art, the purpose of the present invention is to provide a kind of a variety of active principles of combination to greatly improve healing Rate, repairs and reduces scar, at the same effectively inhibit that formaldehyde generates have the medical adhesive for promoting healing and repair function and its Preparation method.

The purpose of the present invention is what is be achieved through the following technical solutions：

It is a kind of that there is the medical adhesive for promoting healing and repair function, which is characterized in that include the component of following parts by weight：a- 20-25 parts of n-butyl cyanoacrylate, a- alpha-cyanoacrylates be monooctyl ester 25-35 parts different, phenylethylene thermoplastic elastomer microballoon 2-6 Part efficiently promotes healing and repairs 25-37 parts of component, 2-4 parts of sodium alginate, 3-6 parts of Sodium Hyaluronate, allantoin 8-10 Part, 1 part of hydrolyzed wheat protein, 1 part of stabilizer, 150-220 parts of composite fruit oil ingredient, 200 parts of sterile water；

The efficient promotion healing and reparation component includes that special efficacy promotes healing and repairs 6 parts of component, natural promotion is cured 12-24 parts of component is closed and repaired, Chinese medicine promotes healing and repairs 6-12 parts of component；

The special efficacy promotes healing and repairs component in parts by weight, including 2 parts of jellyfish extract, starfish extract 2 parts, 1 part of gecko extract, 1 part of samandatrin, 4 parts of octopus polysaccharide, 4 parts of fish skin collagen；

The natural promotion heals and repairs component in parts by weight, including 2 parts of Fructificatio Tricholomatis Matsutakis extract, black fruit fructus lycii carry Take 5 parts of 2 parts of object, 3 parts of cacao seed extract and Kiwi extract；

The Chinese medicine promotes healing and repairs component in parts by weight, including 0.5 part of purple sesame extract, earthworm extraction 1.5 parts of 2 parts of object, 2 parts of Turmeric P.E and Cordyceps extract；

The composite fruit oil ingredient is by aloe, rose hip oil, evening primrose oil and Pu'er tea fruit oil according to weight fraction 5:3:2:1 composition.

Further, the stabilizer is polyanion cellulose and poloxamer according to parts by weight 5：1 is composed；Institute It according to weight ratio is 1 that state the starfish in starfish extract, which be asterias rollestoni, Asterias amuresis and solaster dakisoni Verrill,:1:1 group At；The particle size range of the phenylethylene thermoplastic elastomer microballoon is 50nm-3 μm, and particle diameter distribution is less than 0.5.

Further, the jellyfish and the specific extraction step of starfish extract are：Respectively with the jellyfish and starfish of fresh acquisition For raw material, raw material is cleaned, after shredding, by weight volume ratio be added 6 times of raw material weights 95% ethanol solution, refluxing extraction 3 times, 6 hours every time；Merge extracting solution, recycling design respectively obtains jellyfish extract and starfish extract.

Further, the preparation method of the cacao seed extract specifically includes following steps：By cocoa seed through drying, beat powder After sieve with 100 mesh sieve, obtain the powder of cocoa seed, 95% ethanol solution be then added, in 45 DEG C of water temperature, ultrasonic power 200W items Under part, ultrasonic extraction 35min obtains extracting solution；Extracting solution is filtered and is concentrated under reduced pressure, slurry is obtained；By slurry with 1：15 volumes It is agitated, shake up, after miillpore filter device degerming than being dissolved in deionized water, obtain cacao seed extract.

Further, the preparation method of the black fruit fructus lycii extract is as follows：Black fruit fructus lycii table is washed away with circulating water and mud Ozone generator is passed through in sterile water and cleans black fruit fructus lycii again by sand, after pulp crushing is broken into pulp, by pulp volume Deionized water is added for 30%, while adding pectase 2%, 50 min are stood under the conditions of 33 DEG C after stirring and evenly mixing；After standing Supernatant liquor be added 95% ethanol solution, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 20min, 10 min are centrifuged under 4000rpm/min rotating speeds；Will centrifugation gained supernatant liquor be concentrated into half flowing slurry after, by slurry with 1：20 volume ratios are dissolved in deionized water, agitated, shake up, after miillpore filter device degerming, obtain black fruit fructus lycii extract.

Further, the purple sesame extract, Pheretima extract, Turmeric P.E and Cordyceps extract specifically extract Step is：It takes dry purple sesame, earthworm, turmeric and cordyceps sinensis to crushed 200 mesh sieve respectively, the 90% of 20 times of weight is added The ethanol solution of mass concentration, impregnates 60h, and filtering centrifuges 10min under 3000 rpm/min rotating speeds；Take supernatant, revolving dense It is reduced to a concentration of 1g/ml, concentrate obtains purple sesame extract, Pheretima extract, turmeric extraction respectively through miillpore filter device degerming Object and Cordyceps extract.

A kind of preparation method with the medical adhesive for promoting healing and repair function, which is characterized in that including following step Suddenly：

Nothing is added according to number ratio in sodium alginate, Sodium Hyaluronate, allantoin, hydrolyzed wheat protein, stabilizer by step 1 In bacterium water, 75 DEG C are heated to, stirring and dissolving 150min is cooled to room temperature, obtains water solution A；

Step 2, by a- n-butyl cyanoacrylate, the different monooctyl ester of a- alpha-cyanoacrylates, phenylethylene thermoplastic elastomer microballoon according to Number ratio is heated to 70 DEG C of stirring 80min, is cooled to room temperature, obtains composite fruit oil solution B in composite fruit oil；

Above-mentioned water solution A and composite fruit oil solution B are uniformly mixed by step 3, and are added according to number ratio and are efficiently promoted to be cured Component is closed and repaired, 3.5h is stirred；

Step 4 handles step 3 products therefrom through filtration sterilization, dispense, seal, pack up to have promote healing and The medical adhesive of repair function.

Since it has the advantages that a series of uniquenesses, i.e., singly it is why a-cyanoacrylate class medical adhesive, which quickly grows, Component, it is solvent-free, do not need additional catalyst etc., at normal temperatures can quick-binding.And bonding range is wide, intensity is high, Has the characteristics that instantaneous solidification, it is often more important that such medical adhesive has no toxic side effect substantially to organisms such as skins.Chemical constitution Particularity determine its advantageous property in terms of bonding, the molecular structure of a-cyanoacrylate class compound Alpha -carbon atom attracts the very competent of electronics in CNCH2CCOOR, when chemistry will occur immediately for the anion for touching denier Reaction.Form have on the basic substance gal4 amino acid chain of organism it is a large amount of be in electronegativity group-NH2 and-COOH, when connecing Contacting can react rapidly when a-cyanoacrylate, and the principle is but also medical adhesive is widely used in clinic.Alpha-cyano third The type and size of influence and alkyl of the olefin(e) acid ester for tissue have much relations.Ester group carbochain is longer under normal circumstances, polymerization Reaction rate is slower, reduces to the irritation of tissue, glue-line flexibility improves.The present invention select a- n-butyl cyanoacrylate and The different monooctyl ester of a- alpha-cyanoacrylates itself has good biocompatibility and excellent promotion as the primary raw material in system Healing and repairing performance.Needle seam operation is substituted, is left no trace after so that skin incision is coincide.

Phenylethylene thermoplastic elastomer microballoon has good biocompatibility, blood compatibility, translucency and gas permeability Deng, and still there is excellent adhesion intensity when use under blood and tissue fluid environment and bond lasting feature, and styrene Class thermoplastic elastomer microballoon has effects that uniqueness in terms of tissue repair.Polymer microsphere inherently has the property of adhesive Matter can be used for the reparation and hemostasis of tissue, meanwhile, polymer microsphere can play the role of dispersant in system again.

Allantoin, alias Allantoin, Allantoin, Allantion, Allantoin are a kind of second Interior ureide derivative.About 50,000 tons of the annual production capacity of allantoin in the world at present, market be mainly medicine, cosmetics and Agriculture three big fields, due to traditional handicraft extracted from natural animal-plant natural allantoin content is very low, complex process, cost It is too high, it can not use on a large scale.In terms of medicine, allantoin, which has, promotes cell growth, accelerates wound healing, cutin-softening egg The physiological functions such as white, are the good consolidant and antiulcer agents of skin trauma.In addition, allantoin can be used as alleviating and treating skin Skin xerosis, skin ulcer have good therapeutic effect simultaneously for inflammation.Since allantoin is a kind of amphoteric compound, can combine more Kind of substance forms double salt, have be protected from light, sterilization and anticorrosion, analgesic, antioxidation, skin can be made to keep moisture content, more moisten and It is soft.

The medical material and wound compatibility prepared using alginate as raw material is good, and has the characteristics that quick-acting haemostatic powder, Human tissue organ is can be used for repair and there are promotion healing properties.Sodium alginate chemical molecular formula is (C6H706Na) n, It is a kind of natural polysaecharides carbohydrate, physicochemical properties are：Tasteless white or faint yellow unsetting powder are soluble in Water, hygroscopicity are strong, do not dissolve in the organic solvents such as alcohol, chloroform, have bioadhesive, biocompatibility and biodegradable The features such as.The base material of drug is can be used as to use in medicine and biotechnology field, sodium alginate.Sodium alginate is early in 1938 United States Pharmacopeia is just taken in.Alginic acid is in 1963 annual income British Pharmacopoeias.Alginic acid is not soluble in water, but can expand into the water. Therefore, traditionally, sodium alginate is used as the adhesive of tablet, while sodium alginate also has unique advantage in terms of thickening, sea The good mobility of mosanom can prevent the viscosity during effect product sterilization from declining phenomenon.Meanwhile sodium alginate can also fill When the stabilizer in system, the storage of more convenient product and transport.

Matsutake, scientific name Trichotoma matsutake also known as pine mushroom belong to Chinese Second Class Key Protected Plant.Matsutake be widely distributed in China northeast, Southwest, especially with Sichuan, Yunnan, Jilin great reputation the most, wherein Sichuan Yajiang matsutake because yield is high, head is big, meat is thin, Color and luster is good, the fragrant depth of taste is by favor both domestic and external, up to 1000 tons or more every year of the annual matsutake collection capacity of Yajiang, annual Japan, Yajiang purchase matsutake is come in the not far numerous mountains of the country businessman such as South Korea ten thousand.The wild rare mycotrophy in this rare plateau of matsutake It is abundant, containing multiple proteins, amino acid, polysaccharide, vitamin and mineral, there is analgesic, the effect of keeping fit and healthy, while The powerful work(that nutrition is quickly fed for the surface of a wound can be played in the present invention with polysaccharide special in its ingredient, vitamin and mineral Effect.

Black fruit fructus lycii extracting solution is the water extract of black fruit fructus lycii fruit powder.In lycium ruthenicum fruit rich in protein, amino acid, The ingredients such as flavones, procyanidine, fat, polysaccharide, vitamin E.Protein is the structural material of human skin, gives skin to seek It supports, impaired cell, tissue can be made to obtain the repairing of timely high quality, make skin gloss high resilience.In lycium ruthenicum fruit Containing 17 kinds of amino acid in addition to tryptophan, amino acid is to constitute organism protein and closely bound up most with vital movement One of base substance can provide nutrition, promote growth, maintain normal metabolism.Assessment of Pigment of Lycium ruthenicum Murr is anthocyanin class And flavone compound, inoxidizability are significantly stronger than than vitamin E, and have stabilization to visible light and ultraviolet light.Flavones Inoxidizability be mainly manifested in remove free radical and anti-peroxidation etc..The albumen being rich in lycium ruthenicum fruit The ingredients such as matter, amino acid, procyanidine, polysaccharide, vitamin E can be the healing of wound, and high quality resume and holding are beautiful Powerful support is provided.

Cacao seed extract, is rich in cocoa molecular peptide, carbohydrate and polyphenol, and efficient antioxidant promotes skin to resist indigo plant The oxidative pressure and dermal photodamage that light ray generates, are to help to station skin to ultraviolet and infrared protection the means of supplementing out economy Youthful appearance.Carbohydrate and polyphenol component in cacao seed extract can effectively slow down scar and be formed, and power-assisted keeps beautiful flesh here Skin.

Kiwi berry contains except abundant vitamin C, A, E and potassium, magnesium, cellulose, and it is fewer also to contain other fruit Nutritional ingredient-folic acid for seeing, carrotene, calcium, lutern, amino acid, natural inositol.Vitamin C can strengthening immune system, promote Absorption into wound healing and to irony；Inositol and amino acid can mend consumed nutrition；The perfect ratio of its low-sodium and high-potassium Example can mend and bear the muscle power that the sufferer of operation is lost.Folic acid（folic acid）One of vitamin B complex is equivalent to butterfly Acyl glutamic acid（Pteroylglutamic acid, PGA）, it is Michele（H.K.Mitchell, 1941）It is extracted from the leaf of spinach Purifying, so it is named as folic acid.There is promoting juvenile cell in marrow ripe, the mankind's such as shortage folic acid can cause huge red thin Born of the same parents' property anaemia and leukopenia.Folic acid is necessary material of human body when using sugar and amino acid, is body cell Substance necessary to growth and breeding.Folic acid is worked in the form of tetrahydrofolic acid in vivo, and tetrahydrofolic acid participates in fast in vivo The synthesis and conversion of purine nucleic acid and pyrimidine nucleotide.Folic acid is in manufacture nucleic acid（Ribonucleic acid, DNA）On play the part of weight The role wanted.Folic acid helps the metabolism of protein, and generation and the maturation of red blood cell are collectively promoted with vitamin B12, is manufacture The indispensable substance of red blood cell.Folic acid is also used as Lactobacillus casei（Lactobacillus casei）And other microorganisms Promote proliferation factor and works.Therefore Kiwi extract can more effectively help and promote healing and the high speed of wound It repairs, plays the role of in the component of the present invention very important.

Starfish (starfish) first recorded in《Medical Animals In China will》, it is Echinodermata (Echinodermata) starfish Guiding principle (Asteroidea) animal.Its type is various, resource very abundant, there is 5 mesh, nearly more than 1500 kinds, and China is about more than 100 kind, It is distributed in intertidal zone to 600m deep water.Its shape has three wrists, four wrists, more than ten wrists, up to 50 wrists.Starfish is the bottoms Hai Sheng Dwell animal, and natural disposition is fierce and cruel, specially eats clam, oyster, scallop, abalone, sea cucumber etc..Starfish can carry out fracture reproduction, breed energy Power, power of regeneration are very strong.Starfish taste is salty, mild-natured.The thoughts of returning home, stomach, large intestine channel.Have and the work(such as stomach and alleviating pain, relieving haperacidity, antidiarrheal, calmness Energy.Modern pharmacology it is demonstrated experimentally that there is good medical value at the positions such as its quil, gonad, it is such as antitumor, antiviral, Antibacterial, anti-inflammatory, antiulcer etc..The basic structure of starfish is by quil, bone shell and internal organ composition.Its main component has sterol, sugar Glycosides, alkaloid, a small amount of anthraquinone, lipid, polysaccharide, vitamins, protein, polypeptide and amino acid and terpene etc..Wherein starfish Saponin(e is the main source of its fertility, power of regeneration, and most of starfish saponin is combined with glycoprotein and lipoprotein, only A seldom part exists with free state, and the saponin(e in starfish belongs to steroid saponin, itself just has and adjusts reproduction and development Effect, therefore starfish extract, for the impaired surface of a wound, the tissue etc. of destruction has good promotions healing and transfers Reproduction, the ability for promoting cell Proliferation.Starfish has very strong power of regeneration, it can grow new part in wound quickly. The characteristic of this quick wound reparation of starfish has significant curative effect in terms of wound healing, while having the anti-microbial property of wide spectrum.

Gecko is the common name to clear all clear scorpions of scorpion suborder (Sauria) Gekkonidae (Gekkonidae), be commonly called as lizard, Eaves snake, house lizard, gecko, parthenocissus, eaves dragon, Ba Bihu or big dragon about contain 80 and belong to 750 kinds, wherein about 20 kinds of Gekko, China 8 kinds of production is distributed mainly on all areas on the south southwest and the Yangtze river basin in China.It is accounted for generation in China, people are just to the medicinal of gecko Value expands further investigation.The drug effect of gecko is most of in tail portion, thus often cuts the tail of gecko living and make medicine, waits it again Use is cut again after a raw new tail, with powerful regeneration function.Contain a variety of active ingredients in gecko body, wherein containing hornet poison Analog and protein, vitamin, histamine class ucleosides and amino acid etc., active material also has protein and peptide mixture, gland Glycosides, sulfated polysaccharide, sulfated polysaccharide albumen etc..As only door stunt of gecko, docking escape is always one kind that it is defended oneself Effective means is referred to as " cutting certainly " or " residuum self-defence " in biology.The nerve that body nerve endings discharges after gecko docking Glia growth factor -2, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, transferrins are the factors for promoting bastem cell survival and proliferation；Growth factor class blood platelet Derivative factor, fibroblast growth factor-2 (fibroblast growth factor-2, FGF-2), epidermal growth Factor (epidermal cell growth factor, EGF) etc. can make cell reenter the cell cycle.Therefore, gecko carries Take object effectively can improve and stimulate increment and the power of regeneration of body cell.Polysaccharide protein saccharide portion is glycosaminoglycan, Also known as amidohexose polysaccharide, is generated by fibroblast, is mainly divided to sulphation and non sulphate two classes.Preceding one kind mainly has sulfuric acid Chondroitin, keratan sulfate, heparin sulfate etc.；Latter class is hyaluronic acid, be twist tray around long-chain macromolecule, constitute albumen The trunk of matter polysaccharide compound, other glycosaminoglycans are then combined with protein, and proteoglycan subunit is formed, and the latter passes through knot again Hop protein even forms proteoglycan aggregate with hyaluronic acid long-chain molecule.A large amount of proteoglycan polymer form many small skies The molecular sieve of gap makes matrix become the barrier of restricting bacterial growth, has good antibacterial effect.

Jellyfish Jellyfish belongs to Coelenterata Coelentera, is divided into the water of the jellyfish and water daughter-in-law's guiding principle of Scyphozoa It is female.Jellyfish is distributed in temperate zone, subtropical zone and Tropical Ocean Area, and the littoral seas such as China Shandong, Zhejiang, Fujian, Guangdong are widely distributed. Jellyfish by structure compositions such as umbrella portion, oral arm portion and appendicles, containing abundant protein, fat, carbohydrate, vitamin, The chemical substances such as niacin, phosphorus, iodine, iron have good nutritive value and medical value.Shanxi is for Zhang Hua's《Natural science will》It records, It just has begun to eat for people in Shanxi.Pharmaceutically, have effects that clearing heat and detoxicating, softening and resolving hard mass, blood pressure lowering, can be used to Treat the illnesss such as chronic bronchitis, dermatitis.It is always the dream dreamed of although amputation regenerates for the mankind, It is the instinct saved one's life for jellyfish, the animal of jellyfish classification all has extremely powerful power of regeneration.In jellyfish not only Containing abundant nutriment, while scientist has also extracted vascular endothelial growth factor, antibacterial peptide and agglutinin etc..Its Vascular Endothelial growth participates in vascularization and permeability adjusting because can effectively stimulate cellular proliferation and migrate, for by There is good effect, antibacterial peptide and agglutinin etc. all to have efficient antibacterial ability for the healing and regeneration of traumatic part position, Important auxiliary antibacterial action is played in surface of a wound recuperation.The jellyfish that the present invention uses is Cyanea nozakii.

Newt is tailed amphibians, and the bodily form is similar with lizard, but body surface does not have squama.Newt as it is medicinal when have remove Wet, antipruritic, analgesia is clearing heat and detoxicating, is used for itchy skin eruption, burn etc..Its adult not only it is renewable go out complete tail and Limbs, also renewable spinal cord lead the Various Tissues such as bone, crystalline lens, retina up and down.Egg containing several functions in newt body In vain, gradient albumen, newt keratin, newt surface protein PROD1, bone morphogenetic protein etc. such as before newt, there is also big The fibroblast growth factor of amount, while playing the role of induction and promoting cell division proliferation, to be effectively promoted by wound The healing and reparation of mouth.Samandatrin is the activating cell and activating cell rich in induction programming instruction extracted out of newt body Decomposition product forms.Since samandatrin can promote any one position of newt body to be regenerated, so as to be wound Regeneration offer is mandatory to recompile program, delays sending out for histocyte itself healing instruction, is histocyte regeneration instructions Send out and race against time, to promote wound to be regenerated before incrustation, the perfect of wound is promoted to repair.

Collagen is a kind of protein of special acid composition.It is not only occur most frequent egg in animal and human body White matter, or intracellular connective tissue and the most important function inscape of supporting tissue.Fish belong in Chordata Vertebrate is a kind of aquatic cold-blooded vertebrate, is breathed with the gill have jaw and fin.Two main groups can be divided into： Cartilaginous fish and bony fish.The fingerling named of the whole world is at 2.6 ten thousand kinds or more at present, nearly 3,000 kinds of the existing fish in China, About 1000 kinds or so of middle fresh-water fishes.Fish protein human absorptivity up to 87~98%, and containing abundant vitamin A, D and Trace element, nutritive value are very high.By taking fresh-water fishes as an example, 100 grams 58-70 grams edible, energy 350-480 kilojoules.Often 100 grams of edible parts：70-78 grams of moisture, 0-2.4 grams of carbohydrate, 15-24 grams of protein, fatty 1.8-3.2 grams, ash 0.6-1.8 grams, and containing abundant minerals, vitamin and trace element.Fish not still diet food, and be good food Food, especially fish-skin are treated, in the Southern Song Dynasty of China period medicine book fish-skin on the books as medicinal effect.Theory of traditional Chinese medical science thinks：Fish Skin is sweet in flavor, salty, mild-natured, has effects that nourishing.In terms of dietotherapy, fish-skin contains abundant protein and various trace elements, Its protein is mainly the collagen and glycosaminoglycan fractions of macromolecular, also contain abundant amino acid, these all be protection and Ingredient necessary to skin is repaired, is played the role of during the reconditioning wound healing of skin extremely important.

The active constituent of Cordyceps extract include cordycepin, protein, amino acid, sterol, mannitol, alkaloid, Polysaccharide and minerals；Cordycepin has the function of broad-spectrum antiseptic, it can inhibit streptococcus, Actinobacillus mallei, bacillus anthracis, pig bleeding The growth of the property pathogens such as septicemia bacillus and staphylococcus.In addition, cordycepin is to gypsum sample little gemma tinea bacterium, ulotrichy budlet The skin pathogenicities fungies such as spore tinea bacterium, trichophyton mentagrophytes and hay bacillus also have inhibiting effect.Sugar, which demonstrates cordycepin, to be had Very strong antifungal activity, cordycepin also have stronger antiviral activity.Cordyceps sinensis because of mild in medicine property and, it is warm but not dry, mend and Not stagnant, not only qi-restoratives salubrity, but also the macrobiosis that can cure the disease, pharmacological property are more steady than ginseng, pilose antler, than less receptor matter, illness, season, The limitation at age can all be used and improve immunity and premunition.Meanwhile the Cordyceps sinensis polysaccharide in Cordyceps extract, super oxygen Object mutase SOD, 18 amino acid, vitamin V A, VB1, VB2 and calcium, iron, phosphorus, selenium and other trace elements can greatly improve wound Recovery and healing speed.

Purple sesame is the important member of Ganodermataceae, which is distributed mainly on Subtropic of China and torrid areas, is grown in broad-leaved Tree falls on wood, decayed timber and forest land.According to《Compendium of Materia Medica》Described in：" the wooden sesame of purple sesame one, smell is sweet, warm, nontoxic；Cure mainly ear Deaf, god, strengthening the essence gas, hard muscles and bones, good color, long term usage, not old macrobiosis of making light of one's life by commiting suicide are protected in sharp joint " (Li Shizhen (1518-1593 A.D.) 1978).Ganoderma Sinense is more The fructification of hole Cordycepps fungi purple sesame Ganodermasinense Zhao, Xu et Zhang.Scientific investigations showed that ganoderma lucidum class Pharmaceutical component is very abundant, and wherein effective ingredient can be divided into ten major class, including ganoderma lucidum polysaccharide, ganoderma lucidum polypeptide, triterpenes, 16 kinds of ammonia Base acid (wherein containing seven kinds of essential amino acids), protein, steroid, mannitol, coumarin glycosides, alkaloid, organic acid are (main Containing fumaric acid), and trace element Ge, P, Fe, Ca, Mn, Zn, etc..Ganoderma lucidum has dual regulation to human body.In addition, Most of ingredient in ganoderma lucidum is all to have maintenance effect to skin, it plays treatment different from general drug to certain disease Effect is also different from general nutritional health food and only the deficiency of nutrient in a certain respect is supplemented and strengthened, but whole Bidirectional modulation function of human body balances on body, transfers internal body vigor, adjusts human metabolism's function.It can also promote core The synthesis of acid, protein：Polysaccharide compound contained by purple sesame can promote the synthesis of human body protein, improve hematopoiesis function, To promote illness, sore spot and the wound healing of wound, body is allowed to reach a new equilibrium state again.Purple sesame institute spy contains Peptidoglycan can effectively remove the ability of human free radical, also reduce the production of lipofuscin in the heart, brain, improve the activity of cell With metabolic capability, delaying cell aging simultaneously makes Skin Cell that tight skin be kept to compact, glossy, is the upper good merchantable brand for repairing skin.

Earthworm, Li Shizhen (1518-1593 A.D.) exist《Compendium of Materia Medica》Referred to as has the function of clearing and activating the channels and collaterals, promoting blood circulation and removing blood stasis.Earthworm property is salty-cold, With heat-clearing, calm the frightened, relieving asthma, dredging collateral, promoting blood circulation the effect of.Earthworm can reduce exudation, shorten inflammatory phase, have wound healing The effect of.Pheretima extract has Activity simultaneously, has further facilitation for injured wound healing. Earthworm has removing toxic substances, promoting blood circulation and removing blood stasis, myogenic pain relieving and bacteriostasis, containing a variety of active ingredients, lumbricin, earthworm alkali, purine, Choline, vitamin, amino acid etc. have the effects that preferable fibrinolytic and anti-freezing, and activator of plasminogen vigor can be made to increase, to The healing of the surface of a wound is more efficiently promoting while easing pain antibacterial.

Turmeric Musales, Zingiber, curcuma genus perennial herb, turmeric（Classification system：Curcuma longa L.） Also known as：Radix Curcumae, tripod perfume, milli life, yellow ginger etc..Its main component has curcumin, turmerone, fragrance-turmerone, curcumene, virtue- Fragrant curcumene, sterols, aliphatic acid and Metal Elements K, sodium, magnesium, calcium, manganese, iron, copper, zinc etc..Wherein curcumin has strength Anti-inflammatory, antibacterial, oxidation resistant effect, curcumin can in conjunction with and fish skin collagen, Cordyceps extract, octopus polysaccharide, wall Polysaccharose substance in brave extract and starfish extract, and mutually cooperateed with it, the effective healing for realizing the surface of a wound.

Wheat is as a kind of important agricultural product, and main plantation is in China Middle-north Area, and for a long time, wheat is chiefly used in And powder produces.Protein is the second largest component in wheat flour, hydrolyzed wheat protein：The primary amino acid gliadin of wheat (gl5ad55) and the albumen of Mai Gu it is, a kind of sulfur-containing amino acid containing abundant cystine (cyst55e).It has moisturizing, resists Oxidation and soft refinement skin, have special moisturizing ingredient, can effectively improve skin condition.Meanwhile hydrolyzed wheat egg Essential amino acid is provided for body anabolism in vain, to maintain internal nitrogen budgets.Especially especially suitable for anti-inflammatory and outer The postoperative Protein intake of section.That is, hydrolyzed wheat protein can play supplement nutrient protein, skin is helped to repair simultaneously Multiple and anti-inflammatory effect.

Sodium Hyaluronate can improve skin physiology condition, for dermal collagen and elastomer synthesis provide it is superior The effect of skin care is played in external environment, the supply of reinforced nutrition matter.Hyaluronic acid can prevent the production of some enzymes in cell It is raw, the formation of free radical is reduced, eucaryotic cell structure is destroyed preventing free radical, generate lipid peroxidation and causes the faces such as human body aging It plays an important role, provides suitable place for cell Proliferation and differentiation, directly facilitate cell growth, differentiation, reconstruction and reparation Deng reaching humidification moisturizing and the effect of anti-inflammatory, there is fabulous repair to damage skin.

Aloe is a kind of Liliaceae meat herbaceous plant, originates in Africa.The aloe in incoming China is mainly the library in the U.S. Drag-line aloe, Aloe Liliaceae and Aloe ferox Miller form unique aloe sinensis through cultivating and growing for many years.Aloe contains There are relatively rich sugar, protein, amino acid, vitamin, organized enzyme and various trace elements.Its representative component is aloe anthracene Quinone, aloe is due to containing various bioactivators, civil by the anti-inflammatory, beauty as sterilization, hair care and treatment skin disease Natural drug.Its pharmacological property is return liver warp, the heart channel of Hang-Shaoyin, stomach, large intestine channel.Aloe primary efficacy is：Bactericidal effect；Anti-inflammatory effect； Moisten beautification function；The effect of letting out under stomach invigorating；Cardiac stimulant promoting blood circulation acts on；Immune and antitumor action；Detoxication；Anti-aging effects； Antalgic and sedative acts on.Aloe is blade using position, mainly contains the anthraquinone analog compounds such as aloin, aloe-emodin.Anthraquinone Class compound is main part in aloe organic active ingredients, including aloin (Aloin), also known as aloin, reed Luxuriant growth glucoside, aloe-emodin (Aloeemodin).Wherein aloin is most basic one of ingredient, has data to show in aloe sinensis Aloin content average out to：335.28mg/g.According to wearing such as qin：The component of polysaccharide is mannose, half in aloe sinensis leaf Lactose, glucose, xylose, arabinose, rhamnose, total content 3.45%.Relative amount mannose is 60.73%, galactolipin 16.42%, glucose 9.16%, xylose 3.83%, arabinose 5.45%, rhamnose 4.42%.Total protein content 9.50% or more.

Aloe has the irreplaceable special health-care effect for skin of other greases, is suitble to various skin quality, especially right Oily and easy inflammation skin are very helpful.Pure oiliness aloe lime set contained by aloe, can give injured skin and The moist and nutrient of the skin deeper to dry out, and impaired cell tissue is repaired rapidly, promote cytothesis, enables skin Quickly get well.

Rose hip oil deep layer moisturizing, provide nutrient, make skin it is soft, it is soft, moisten, prevent ultraviolet light from being made to skin At injury, skin whitening；Increase vigor of skin tissue, keep skin high resilience, dry cracked skin can be made to restore its brilliance naturally, It can improve and eliminate new and old scar after wound, the scar etc. left after sunburn, burn scar, operation.Rose hip oil can pass through promotion The activity of epidermal cell improves skin regeneration and updating ability, promotes new skin regeneration to have, due to being rich in natural dimension life Plain C, rose hip oil can also restore the optimum balance between aliphatic acid and moisture, and effective moist and maintenance can be played to skin and is made With.

Evening primrose oil contains saturated fatty acid and unsaturated fatty acid, wherein the high-carbon fat such as oleic acid, linoleic acid, gamma-Linolenic acid Fat acid content is very high, has resilient flexible sense to skin, and tactile and ductility are fine, and are easily absorbed by skin heart, can promote Into blood circulation, epidermal cell angling is prevented.Evening primrose oil is provided containing saturated fatty acid and unsaturated fatty acid for skin texture Sufficient toughness can restore the normal barrier function of skin.Evening primrose oil is harmless, non-stimulated, and to burn, wound There is preferable medical assistance to act on.

Pu'er tea fruit oil has high nutritive value, is rich in tea polyphenols, inherently has by force anti-oxidant and anti-inflammatory Effect, can improve the disposable performance of integumentary system, while tea polyphenols have good effect for the raising of human body body energy. Tea polyphenols have good reproducibility, convergence and antibiotic property, are clinically used for treatment local hemorrhage.In general, Pu'er tea fruit oil It is to have had both antibacterial, function and the one of anti-inflammatory, anti-oxidant, hemostasis and protection skin.

Native cellulose is that the polysaccharide most wide, content is most, source very abundant are distributed in nature.Current fibre element Modification technology is concentrated mainly on two aspect of etherificate and esterification.Carboxymethylation reaction is one kind of etherification technology.Cellulose is through carboxylic first Carboxymethyl cellulose is obtained after base（CMC）, aqueous solution is with works such as thickening, the protections of film forming, gluing, water tariff collection, colloid With.The high-end substitute products of carboxymethyl cellulose (CMC) are that polyanion cellulose (PAC) is also a kind of anionic cellulose Ether has higher degree of substitution and the substitution uniformity, and strand is shorter, and molecular structure is more stable, therefore with preferably comprehensive Performance is closed, dissolubility also enhances.Applied to the applicable all industries of carboxymethyl cellulose, it is possible to provide better stability and Meet higher technological requirement.Poloxamer (Poloxamer) is polyoxyethylene poly-oxygen propylene aether block copolymer, trade name Pluronic (Pluronic).This is a kind of novel macromolecule nonionic surfactant.Polyanion cellulose (PAC) and Being used in combination for both substances of poloxamer effectively can provide better stability for reaction system, while can enhance The bond properties of medical adhesive simultaneously has moisture retaining quality.

As a result of above technical scheme, the present invention has the advantages that：

1, wound healing is to be participated in, interacted jointly by inflammatory cell, epidermal cell, endothelial cell and fibroblast etc. Biochemistry and cytological process, and synthesized by fibroblast and the collagen secreted be then wound tissue main component. The present invention has the medical adhesive for promoting healing and repair function by testing the efficient promotion selected healing repeatedly and repairing All contain the important component that the process can be promoted to occur in component, can effectively improve the rate of wound healing, while right Also there is good effect in the reparation of scar.The jellyfish extract of special efficacy promotion healing and reparation component selection of the present invention, Starfish extract, gecko extract, samandatrin its organism itself all have the regenerated function of powerful amputation, in extract Also contain the various composition for promoting cell Proliferation and the important substance for promoting tissue repair, special efficacy of the present invention promotes healing and repaiies Multiple component makes full use of the promotion functions in various extracts for cell Proliferation and regeneration, in combination with octopus polysaccharide and Promotion wound healing of the fish skin collagen for the complementary capabilities strength of albumen and damaged skin thus forms this strong effective hair The promotion healing system of bright special efficacy.

In conjunction with it is natural promote healing and repair protein in component Fructificatio Tricholomatis Matsutakis extract, amino acid, special polysaccharide and Minerals；Protein, amino acid, flavones, procyanidine in black fruit fructus lycii extract and polysaccharide；It is rich in cacao seed extract Cocoa molecular peptide, carbohydrate and polyphenol；Folic acid, inositol in Kiwi extract and amino acid, the natural promotion are healed and are repaiied Multiple components system can give skin with nutrition, promote healing, and impaired cell, tissue can be made to obtain repairing for timely high quality It mends, and the protective layer for skin can be established.

In conjunction with Chinese medicine promote healing and repair component in Cordyceps extract active constituent cordycepin, protein, Amino acid, sterol etc.；Ganoderma lucidum polysaccharide, ganoderma lucidum polypeptide, triterpenes, alkaloid and a variety of amino acid in purple sesame extract etc., Lumbricin in Pheretima extract, earthworm alkali, purine, choline, vitamin, amino acid etc.；Curcumin, ginger in Turmeric P.E Flavones, fragrance-turmerone, curcumene, the fragrant curcumene of virtue-, sterols etc., in Chinese medicine promotes healing and reparation components system Many kinds of substance forms powerful recovery and repair ability system.Three major controls active ingredient complements each other, mutually collaboration to The effective present invention that realizes is efficiently promoting healing and repairs the purpose of wounded tissue.

2, the present invention combines animal protein simultaneously, and vegetable protein combines albumen and its sterilization in composite fruit oil anti-again Inflammation effect, makes the sore wound healing on skin, further increases the immunity of skin, simultaneously because fish skin collagen, wheat Also contain a large amount of protein in protein hydrolysate black fruit fructus lycii and aloe, trace element can improve skin texture, keep skin tight It causes, is formed simultaneously protective barrier, multiple protein, amino acid and trace element, which combine, makes product of the present invention It is better.

3, the present invention has sodium alginate, Sodium Hyaluronate, the urine for promoting the medical adhesive of healing and repair function to select The auxiliary elements such as Bursin, hydrolyzed wheat protein, stabilizer with comprehensively improve entire product is long-acting, be efficiently promoting healing and Repairing performance, while improving the comprehensive mechanical property of adhesive of medical of the present invention, substantially reduce the risk of user.The present invention's Compound additive is combined with other components, can enhance the gas permeability and permeability of final cosmetic product, improves final products Repairing effect.

4, the present invention has the composite fruit oil for promoting the medical adhesive of healing and repair function to select, by aloe, rose The collaboration of fruit oil, evening primrose oil and Pu'er tea fruit oil uses so that the entire fruit oil base body for participating in reaction can be simultaneously and fast Speed, which is realized, repairs impaired cell tissue, promotes cytothesis and wound healing, promotes blood circulation, and deeper nourishes skin, New and old scar can be the function that new skin establish protective barrier simultaneously after improvement and elimination wound.Composite fruit oil is combined as this The basis of most stable of promotion healing and reparation that the adhesive of medical of invention provides can continue, effectively enhancing skin supports Drag effectively prevent oxidative damage, while can repair skin, improves scar, and wound healing is promoted to restore.

5, there is the present invention medical adhesive for promoting healing and repair function to be especially added with allantoin, there is its uniqueness And important role.Allantoin, which has, promotes cell growth, accelerates wound healing, the physiological functions such as cutin-softening albumen, are skins The good consolidant of skin wound.In addition, allantoin can be used as alleviating and treat xerodermia, skin ulcer, simultaneously for inflammation Disease has good therapeutic effect.Since allantoin is a kind of amphoteric compound, double salt can be formed in conjunction with many kinds of substance, have and be protected from light, sterilize Anti-corrosion, analgesic, antioxidation can make skin keep moisture content, more moisten and soft.The use of allantoin, at the same it is also suitable In acting as formaldehyde inhibitor in system, effectively play the role of formaldehyde inhibitor, therefore this system is without additional addition Individual formaldehyde inhibitor and preservative.

6, the present invention has the curcumin that Turmeric P.E contains in the medical adhesive for promoting healing and repair function can In conjunction with the polysaccharide object in fish skin collagen, Cordyceps extract, octopus polysaccharide, gecko extract and starfish extract Matter, and mutually cooperateed with it, the effective healing for realizing the surface of a wound.

7, there is each other than stabilizer for promoting the medical adhesive of healing and repair function to select to add for invention Addition, which point all has, is efficiently promoting healing and repair function, becomes that entire promote healing and repair product must can not The effect of few component part, a variety of promotion healings and reparation component, is like nature itself, and the present invention, which is prepared, has rush Into healing and the medical adhesive of repair function.Sodium alginate is a kind of natural polysaecharides carbohydrate, is original with alginate Expect that the medical material prepared and wound compatibility are good, and have the characteristics that quick-acting haemostatic powder, can be used for human tissue organ and repair Redoubling, which has, promotes healing and repairing performance.The primary amino acid gliadin of wheat and the albumen of Mai Gu, containing abundant Cystine be a kind of sulfur-containing amino acid.Hydrolyzed wheat protein can play simultaneously supplement nutrient protein, help skin repair with And anti-inflammatory effect.Hyaluronic acid can prevent the generation of some enzymes in cell, reduce the formation of free radical, prevent free radical Eucaryotic cell structure is destroyed, lipid peroxidation is generated and the faces such as human body aging is caused to play an important role, is carried with differentiation for cell Proliferation For suitable place, cell growth, differentiation, reconstruction and reparation etc. are directly facilitated, there is fabulous repair to damage skin. Allantoin, which has, promotes cell growth, accelerates wound healing, and the physiological functions such as cutin-softening albumen are that the good of skin trauma is cured Mixture.In conclusion whole addition raw materials itself that the present invention selects all have promotion healing and repairing performance, it is basic herein Upper and increase special efficacy promotes to heal and repair component, naturally promotion healing and reparation component, Chinese medicine promote to heal and repair Multiple component three promotes greatly healing and repairs promotion healing and the repairing performance of system General Promotion product, synergistic function Under necessarily so that having of preparing of the present invention promotes the medical adhesive of healing and repair function to have, more strength is efficient to be promoted Into healing and repairing performance, while comprehensive performance is also more complete.

There is the present invention adhesion strength for promoting the medical adhesive of healing and repair function to be all higher than 60N, to golden yellow Portugal The antibiotic rate of grape coccus is up to 97.7% or more, and whole healing efficiency is up to 98.5% or more, and biocompatibility is high, to wound tissue It is non-stimulated, sensitization rate is reduced, comprehensive performance is outstanding, meets the clinical application requirement to adhesive of medical, medical viscous by improving The promotion healing of mixture and repairing performance reduce the spirit and psychological pressure of patient to greatest extent.

Specific implementation mode

The present invention is specifically described below by specific embodiment：

Embodiment 1

It is a kind of that there is the medical adhesive for promoting healing and repair function, include the component of following parts by weight：

25 parts of the different monooctyl ester of 20 parts of a- n-butyl cyanoacrylate, a- alpha-cyanoacrylates, 2 parts of phenylethylene thermoplastic elastomer microballoon, Efficiently promote healing and repairs 25 parts of component, 2 parts of sodium alginate, 3 parts of Sodium Hyaluronate, 8 parts of allantoin, hydrolyzed wheat egg White 1 part, 1 part of stabilizer, 150 parts of composite fruit oil ingredient, 200 parts of sterile water；Efficiently promote healing and repair component to include spy It imitates and promotes healing and 6 parts of component of reparation, natural promotion healing and repair 12 parts of component, Chinese medicine promotion healing and reparation group Divide 6 parts；Special efficacy promote healing and repair component in parts by weight, including 2 parts of jellyfish extract, 2 parts of starfish extract, 1 part of gecko extract, 1 part of samandatrin, 4 parts of octopus polysaccharide, 4 parts of fish skin collagen；It is natural promote healing and repair component according to Parts by weight meter, including 2 parts of Fructificatio Tricholomatis Matsutakis extract, 2 parts of black fruit fructus lycii extract, 3 parts of cacao seed extract and Kiwi berry extraction 5 parts of object；Chinese medicine promotes healing and repairs component in parts by weight, including 0.5 part of purple sesame extract, Pheretima extract 2 1.5 parts of part, 2 parts of Turmeric P.E and Cordyceps extract；Composite fruit oil ingredient was seen by aloe, rose hip oil, the moon Careless oil and Pu'er tea fruit oil are according to weight fraction 5:3:2:1 composition.

Stabilizer is polyanion cellulose and poloxamer according to parts by weight 5：1 is composed；In starfish extract Starfish be asterias rollestoni, Asterias amuresis and solaster dakisoni Verrill according to weight ratio be 1:1:1 composition；Phenylethylene thermoplastic The particle size range of elastomer microspheres is 50nm-3 μm, and particle diameter distribution is less than 0.5.

Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested As a result it is：It is 61N that the present invention, which has the adhesion strength for the medical adhesive for promoting healing and repair function, to staphylococcus aureus Antibiotic rate reach 97.7% or more, whole healing rate rate reaches 98.5%.

Embodiment 2

It is a kind of that there is the medical adhesive for promoting healing and repair function, include the component of following parts by weight：

28 parts of the different monooctyl ester of 22 parts of a- n-butyl cyanoacrylate, a- alpha-cyanoacrylates, 4 parts of phenylethylene thermoplastic elastomer microballoon, Efficiently promote healing and repairs 30 parts of component, 3 parts of sodium alginate, 4 parts of Sodium Hyaluronate, 9 parts of allantoin, hydrolyzed wheat egg White 1 part, 1 part of stabilizer, 180 parts of composite fruit oil ingredient, 200 parts of sterile water；Efficiently promote healing and repair component to include spy It imitates and promotes healing and 6 parts of component of reparation, natural promotion healing and repair 17 parts of component, Chinese medicine promotion healing and reparation group Divide 9 parts；Special efficacy promote healing and repair component in parts by weight, including 2 parts of jellyfish extract, 2 parts of starfish extract, 1 part of gecko extract, 1 part of samandatrin, 4 parts of octopus polysaccharide, 4 parts of fish skin collagen；It is natural promote healing and repair component according to Parts by weight meter, including 2 parts of Fructificatio Tricholomatis Matsutakis extract, 2 parts of black fruit fructus lycii extract, 3 parts of cacao seed extract and Kiwi berry extraction 5 parts of object；Chinese medicine promotes healing and repairs component in parts by weight, including 0.5 part of purple sesame extract, Pheretima extract 2 1.5 parts of part, 2 parts of Turmeric P.E and Cordyceps extract；Composite fruit oil ingredient was seen by aloe, rose hip oil, the moon Careless oil and Pu'er tea fruit oil are according to weight fraction 5:3:2:1 composition.

Stabilizer is polyanion cellulose and poloxamer according to parts by weight 5：1 is composed；In starfish extract Starfish be asterias rollestoni, Asterias amuresis and solaster dakisoni Verrill according to weight ratio be 1:1:1 composition；Phenylethylene thermoplastic The particle size range of elastomer microspheres is 50nm-3 μm, and particle diameter distribution is less than 0.5.

Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested As a result it is：It is 62N that the present invention, which has the adhesion strength for the medical adhesive for promoting healing and repair function, to staphylococcus aureus Antibiotic rate be 98% or more, whole healing rate rate reaches 99%.

Embodiment 3

It is a kind of that there is the medical adhesive for promoting healing and repair function, include the component of following parts by weight：

33 parts of the different monooctyl ester of 24 parts of a- n-butyl cyanoacrylate, a- alpha-cyanoacrylates, 5 parts of phenylethylene thermoplastic elastomer microballoon, Efficiently promote healing and repairs 35 parts of component, 4 parts of sodium alginate, 5 parts of Sodium Hyaluronate, 10 parts of allantoin, hydrolyzed wheat egg White 1 part, 1 part of stabilizer, 210 parts of composite fruit oil ingredient, 200 parts of sterile water；Efficiently promote healing and repair component to include spy It imitates and promotes healing and 6 parts of component of reparation, natural promotion healing and repair 22 parts of component, Chinese medicine promotion healing and reparation group Divide 10 parts；Special efficacy promotes healing and repairs component in parts by weight, including 2 parts of jellyfish extract, starfish extract 2 Part, 1 part of gecko extract, 1 part of samandatrin, 4 parts of octopus polysaccharide, 4 parts of fish skin collagen；It is natural that healing and reparation component is promoted to press It is carried according to parts by weight meter, including 2 parts of Fructificatio Tricholomatis Matsutakis extract, 2 parts of black fruit fructus lycii extract, 3 parts of cacao seed extract and Kiwi berry Take 5 parts of object；Chinese medicine promotes healing and repairs component in parts by weight, including 0.5 part of purple sesame extract, Pheretima extract 1.5 parts of 2 parts, 2 parts of Turmeric P.E and Cordyceps extract；Composite fruit oil ingredient was seen by aloe, rose hip oil, the moon Careless oil and Pu'er tea fruit oil are according to weight fraction 5:3:2:1 composition.

Stabilizer is polyanion cellulose and poloxamer according to parts by weight 5：1 is composed；In starfish extract Starfish be asterias rollestoni, Asterias amuresis and solaster dakisoni Verrill according to weight ratio be 1:1:1 composition；Phenylethylene thermoplastic The particle size range of elastomer microspheres is 50nm-3 μm, and particle diameter distribution is less than 0.5.

Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested As a result it is：It is 61.5N that the present invention, which has the adhesion strength for the medical adhesive for promoting healing and repair function, to Staphylococcus aureus The antibiotic rate of bacterium is 98.2% or more, and whole healing rate rate reaches 99%.

Embodiment 4

It is a kind of that there is the medical adhesive for promoting healing and repair function, include the component of following parts by weight：

35 parts of the different monooctyl ester of 25 parts of a- n-butyl cyanoacrylate, a- alpha-cyanoacrylates, 6 parts of phenylethylene thermoplastic elastomer microballoon, Efficiently promote healing and repairs 37 parts of component, 4 parts of sodium alginate, 6 parts of Sodium Hyaluronate, 10 parts of allantoin, hydrolyzed wheat egg White 1 part, 1 part of stabilizer, 220 parts of composite fruit oil ingredient, 200 parts of sterile water；Efficiently promote healing and repair component to include spy It imitates and promotes healing and 6 parts of component of reparation, natural promotion healing and repair 24 parts of component, Chinese medicine promotion healing and reparation group Divide 12 parts；Special efficacy promotes healing and repairs component in parts by weight, including 2 parts of jellyfish extract, starfish extract 2 Part, 1 part of gecko extract, 1 part of samandatrin, 4 parts of octopus polysaccharide, 4 parts of fish skin collagen；It is natural that healing and reparation component is promoted to press It is carried according to parts by weight meter, including 2 parts of Fructificatio Tricholomatis Matsutakis extract, 2 parts of black fruit fructus lycii extract, 3 parts of cacao seed extract and Kiwi berry Take 5 parts of object；Chinese medicine promotes healing and repairs component in parts by weight, including 0.5 part of purple sesame extract, Pheretima extract 1.5 parts of 2 parts, 2 parts of Turmeric P.E and Cordyceps extract；Composite fruit oil ingredient was seen by aloe, rose hip oil, the moon Careless oil and Pu'er tea fruit oil are according to weight fraction 5:3:2:1 composition.

Stabilizer is polyanion cellulose and poloxamer according to parts by weight 5：1 is composed；In starfish extract Starfish be asterias rollestoni, Asterias amuresis and solaster dakisoni Verrill according to weight ratio be 1:1:1 composition；Phenylethylene thermoplastic The particle size range of elastomer microspheres is 50nm-3 μm, and particle diameter distribution is less than 0.5.

Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested As a result it is：It is 62N that the present invention, which has the adhesion strength for the medical adhesive for promoting healing and repair function, to staphylococcus aureus Antibiotic rate be 98% or more, whole healing rate rate reaches 99%.

In above-mentioned each embodiment

The preparation method of jellyfish extract and starfish extract is as follows：

Respectively using the jellyfish of fresh acquisition and starfish as raw material, raw material is cleaned, and after shredding, 6 times of originals are added in volume ratio by weight 95% ethanol solution of material weight, refluxing extraction 3 times, 6 hours every time；Merge extracting solution, recycling design respectively obtains jellyfish extraction Object and starfish extract.

The preparation method of cacao seed extract is as follows：

By cocoa seed through drying, beat powder after sieve with 100 mesh sieve, obtain the powder of cocoa seed, 95% ethanol solution be then added, 45 DEG C of water temperature, under the conditions of ultrasonic power 200W, ultrasonic extraction 35min obtains extracting solution；Extracting solution is filtered and is concentrated under reduced pressure, must be starched Shape object；By slurry with 1：15 volume ratios are dissolved in deionized water, agitated, shake up, after miillpore filter device degerming, and obtaining can It can seed extract.

The preparation method of Kiwi extract is as follows：

The Kiwi extract is the ethanol extract of Kiwi berry, and specific extraction step is：Dry Kiwi berry is taken to crushed 60 mesh sieve, and the ethanol solution of 90% mass concentration of 17 times of weight is added, and impregnate 50h, filter, under 3000 rpm/min rotating speeds Centrifuge 10min；Supernatant is taken, concentrated by rotary evaporation to a concentration of 1.5g/ml, concentrate is through miillpore filter device degerming to get Kiwi berry Extract.

The preparation method of Fructificatio Tricholomatis Matsutakis extract is as follows：

Wild matsutake slice, drying, obtained matsutake air dried sheet is taken to crush matsutake air dried sheet, in mass ratio 1:6 add to 90% Ethanol solution in, and impregnate 40 hours, then circumfluence distillation 8 hours, and obtained circumfluence distillation object is refined, Ethyl alcohol is recycled, then is concentrated under reduced pressure, filters, and obtained filtrate decompression is concentrated, B liquid is refining to obtain, does not allow what is be obtained by filtration Object, which adds in butanediol aqueous solution, to be dissolved, and A liquid is refining to obtain, and is then uniformly mixed A liquid with B liquid, and deposited under conditions of 1 DEG C 50h is put to get to Fructificatio Tricholomatis Matsutakis extract.

The preparation method of black fruit fructus lycii extract is as follows：

Black fruit fructus lycii table is washed away with circulating water and silt, and ozone generator is passed through in sterile water and cleans black fruit fructus lycii again, it will Pulp crushing is broken into after pulp, is 30% addition deionized water by pulp volume, while adding pectase 2%, after stirring and evenly mixing 50 min are stood under the conditions of 33 DEG C；95% ethanol solution is added in supernatant liquor after standing, in 40 DEG C of water temperature, ultrasonic power Under the conditions of 200W, ultrasonic extraction 20min centrifuges 10 min under 4000rpm/min rotating speeds；It will centrifugation gained supernatant liquor concentration To half flowing slurry, by slurry with 1：20 volume ratios are dissolved in deionized water, agitated, shake up, through miillpore filter device After degerming, black fruit fructus lycii extract is obtained.

Purple sesame extract, Pheretima extract, Turmeric P.E and the specific extraction step of Cordyceps extract are：

It takes dry purple sesame, earthworm, turmeric and cordyceps sinensis to crushed 200 mesh sieve respectively, 90% matter of 20 times of weight is added The ethanol solution of concentration is measured, 60h is impregnated, filtering centrifuges 10min under 3000 rpm/min rotating speeds；Take supernatant, concentrated by rotary evaporation To a concentration of 1g/ml, concentrate obtains purple sesame extract, Pheretima extract, Turmeric P.E respectively through miillpore filter device degerming And Cordyceps extract.

The above-mentioned preparation method with the medical adhesive for promoting healing and repair function, includes the following steps：

Nothing is added according to number ratio in sodium alginate, Sodium Hyaluronate, allantoin, hydrolyzed wheat protein, stabilizer by step 1 In bacterium water, 75 DEG C are heated to, stirring and dissolving 150min is cooled to room temperature, obtains water solution A；

Step 2, by a- n-butyl cyanoacrylate, the different monooctyl ester of a- alpha-cyanoacrylates, phenylethylene thermoplastic elastomer microballoon according to Number ratio is heated to 70 DEG C of stirring 80min, is cooled to room temperature, obtains composite fruit oil solution B in composite fruit oil；

Above-mentioned water solution A and composite fruit oil solution B are uniformly mixed by step 3, and are added according to number ratio and are efficiently promoted to be cured Component is closed and repaired, 3.5h is stirred；

Step 4 handles step 3 products therefrom through filtration sterilization, dispense, seal, pack up to have promote healing and The medical adhesive of repair function.

Performance test

Adhesive of medical is prepared using above-described embodiment to smear wound, the present invention, which has, promotes healing and repair function The adhesion strength of medical adhesive be all higher than 60N, 97.7% or more is up to staphylococcus aureus antibiotic rate, whole healing efficiency Up to 98.5% or more, biocompatibility is high, non-stimulated to wound tissue, reduces sensitization rate, comprehensive performance is outstanding, meets clinic To the application requirement of adhesive of medical, reduced to greatest extent by the promotion healing and repairing performance that improve adhesive of medical The spirit and psychological pressure of patient.

Example the above is only the implementation of the present invention is not intended to limit the scope of the invention, every to utilize this hair Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks Domain is included within the scope of the present invention.

Claims (1)

1. a kind of having the preparation method for promoting healing and repair function medical adhesive, which is characterized in that include the following steps：

Nothing is added according to number ratio in sodium alginate, Sodium Hyaluronate, allantoin, hydrolyzed wheat protein, stabilizer by step 1 In bacterium water, 75 DEG C are heated to, stirring and dissolving 150min is cooled to room temperature, obtains water solution A；

Step 2, by a- n-butyl cyanoacrylate, the different monooctyl ester of a- alpha-cyanoacrylates, phenylethylene thermoplastic elastomer microballoon according to Number ratio is heated to 85 DEG C of stirring 70min, is cooled to room temperature, obtains composite fruit oil solution B in composite fruit oil；

Above-mentioned water solution A and composite fruit oil solution B are uniformly mixed by step 3, and are added according to number ratio and are efficiently promoted to be cured Component is closed and repaired, 3.5h is stirred；

Step 4 handles step 3 products therefrom through filtration sterilization, dispense, seal, pack up to have promote healing and The medical adhesive of repair function.