JP2006219431A - Composition having rough skin-preventing activity, cosmetic and beverage - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition having rough skin-preventing activity, and to provide a cosmetic and a beverage containing the composition. <P>SOLUTION: The composition having the rough skin-preventing activity contains one or more kinds of cucumber juice, carrot essence, peach leaf essence, chamomile flower essence and leaf bud essence of beech. The cosmetic having the rough skin-preventing activity contains the composition. The beverage having the rough skin-preventing activity contains the composition. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

The present invention relates to a composition having an effect of preventing rough skin and a cosmetic containing the composition.

In order to prevent rough skin, first of all, it is necessary not to drastically reduce the intake of lipids, and then to take vitamins that are effective for rough skin. As a measure of lipid intake, according to the four-group scoring method, fats and oils such as butter and vegetable oils themselves are 2 points (= 160 kcal). The nutritional requirement is shown as the ratio of lipid energy to the total energy intake, which also includes the lipids contained in all foods such as meat and fish. In 18-29 year old boys with a daily activity intensity of 2, 460-575 kcal in terms of energy, and intake of lipids equivalent to 360-450 kcal is recommended for girls with the same conditions. It is desirable to take from food as much as possible. Vitamin intake is also important. However, vitamins are not as effective as they are consumed. Fat-soluble vitamins have an allowable upper limit, and water-soluble vitamins are excreted in urine if the intake is too high. Therefore, it is enough to take it consciously in a normal diet without taking excessive amounts.

Vitamin B2, which enhances protein and lipid metabolism, is particularly effective in preventing the formation of lipid peroxide, which causes skin aging, and improving skin metabolism to prevent rough skin. In the same way, vitamin B6, which promotes skin metabolism, also has the effect of correcting skin roughness.
Niacin works to improve blood circulation and maintain smoothness. The vitamin B group works with each other, so it is more effective to take it together than to take it alone.
Vitamin A works to keep the mucosal tissue normal and smooth the skin. Vitamin C, which prevents skin spots caused by ultraviolet rays and reinforces collagen in the skin, is a strong point of view to protect the skin. Vitamin E improves blood circulation and helps metabolism, preventing skin aging by the antioxidant action of β-carotene and vitamin E. Nutrients related to moisturizing (moisturizing) skin make intercellular lipids with unsaturated fatty acids and vitamin A that are abundant in fish and vegetable oils and moisturize the skin.
In particular, it is said that it is good to take DHA / EPA that is abundant in blue fish. Zinc works well to make the skin keratinous tissue, to make the skin strong and to promote the regeneration of mucosal cells. Collagen is important for making the skin, but when applied to the skin, it is blocked by the stratum corneum barrier and does not enter the skin and accumulates on the surface, temporarily containing moisture and `` moist '' It is said that can be obtained. When you drink or eat collagen itself, it is broken down in the stomach and intestines to become amino acids and re-synthesized into collagen necessary for the body, but it does not necessarily create skin.

Moisturizing effect is expected for soap containing brown sugar and rice bran. Lemon packs contain a substance called psoralen in citrus fruits, and it is said that the skin may become darkened and stained when exposed to the sun. Also, even if you slice the pepper and potatoes into thin packs, there is no harm, but the effect seems to be almost the same as when a cold towel is applied. Calcium oxalate and garlic allicin contained in kiwifruit pulp can cause harm to the skin if applied directly to the skin.

Growing up in the harsh natural environment of the Andes Mountains, Maca contains nutrients that are important to the skin, creating beautiful skin and reducing the increase in melanin pigments. In addition, ultraviolet rays generate a large amount of active oxygen in the skin and cause spots and wrinkles, but Maka's antioxidant power is thought to reduce active oxygen and prevent skin problems caused by ultraviolet rays. . An essential amino acid that is important for the skin and the body is nutrition that cannot be made in the body. Therefore, in order to replenish essential amino acids, it is necessary to ingest from meals, etc., and it is also essential for the body. “Maca” contains plenty of these essential amino acids.

In general, it is due to lack of moisture in the stratum corneum, but it seems that the nose is hard and sensitive, so it is necessary to care for the skin to be soft. Moisturizing is important to soften the skin, but it should be moisturized after supplementing with lotion. It is also possible that there is not enough water for the oil. In addition, when applying make-up, it is desirable to make a thin coat after creating a protective film on the bare skin with basic cosmetics. If the foundation is a powder type, it will take away moisture and fat and dry your skin. The liquid type is better. Careful and enjoyable care for the foundation, considering one of the basic makeups, leads to beautiful healthy skin. Irregular life and smoking are not good for your skin and your health. The whole body and skin are linked. Physical problems are immediately reflected in the skin. It is said that the deterioration of skin begins at about 20 years old, depending on the constitution. If you have sensitive skin, it is important to protect your skin with care and care so as not to strain the skin. Sensitive skin is known to be deficient in ceramide, an intercellular lipid. For this reason, sensitive skin is usually dry. Skin is regularly exposed to various stimuli such as changes in temperature, air drying, dust, germs, and ultraviolet rays. There is a lack of a sebum film with a barrier function to prevent this irritation. It is sensitive to all kinds of irritation, so it is a characteristic of sensitive skin that it reacts quickly.

Originally, the skin is an organ that secretes and discharges waste products, sweat, and sebum from metabolism. When these functions decline, naturally the skin itself will also decline. Your skin tries to keep it healthy with your own strength. However, because it is covered with oil such as cosmetics, sweat glands and pores are blocked, and the skin cannot drain sweat and sebum, and cannot breathe, and metabolism is not actively performed. The original barrier function is also degraded. When it becomes dry skin, it is easy to feel dry and looks dull. The makeup of the makeup also worsens, and the foundation is applied thicker, which can have an adverse effect on the skin.
Therefore, it is necessary to prevent anything from drying your skin. It is fatal to dry your skin. If dry water in the winter, ultraviolet rays falling from the sky, the effects of air conditioning and heating, the metabolic function declines, etc., the necessary moisture cannot be maintained sufficiently and the water retention capacity of the stratum corneum cannot be maintained, causing dryness and rough skin It becomes like this. Moisture can cause wrinkles and cause various skin problems. Since the skin is a secretory and excretory organ, the skin hardly absorbs nutrients given from the outside.
On the contrary, if you continue to apply lotion, cream, milky lotion, you won't be able to regain the power to make your skin clean by yourself. The structure of the epidermis consists of four layers from the top: stratum corneum, granule layer, spiny layer, and basal layer. The epidermal cells that are born in the basal layer and reach the stratum corneum eventually become red and peel off, that is, the skin tissue is replaced. In order to recover lost skin as quickly as possible, you can have a healthy life, as well as daily cleansing, and cleansing your skin every day by removing makeup stains and waste from the pores. It is also important to ensure that this is done smoothly.

The following are known foods that are thought to be effective for rough skin.
Foods that contain zinc that may be effective against rough skin: oysters, meat, natto, scallops, black rice. Foods containing coenzyme Q10, which seems to be effective for rough skin: liver, rice bran, avocado, peanuts, spinach, soybeans, rice cakes, and sardines. Foods that contain collagen that may be effective for rough skin: Anago, eel, salmon, sanma, dojo, shark fin, fugu, burdock, abalone, sea bream, sardine, chicken, cartilage, mutton. Foods that contain ceramide that may be effective for rough skin: wheat, soy, millet, spinach, rice, yogurt, jelly. Foods containing niacin that may be effective for rough skin: flying fish, strawberry, marinated, scallop, corn, soy, pork liver, tarako, bonito, maitake, shimeji, taro, broad bean, boiled, Thai, sardine, dried Shiitake mushrooms, eringi, green peas, red beans, beef liver, puffer, salmon, glue, oyster mushrooms, enoki mushrooms, peanuts, buckwheat, black rice. Foods containing biotin that may be effective against rough skin: soy, egg yolk, and pork liver. Foods containing vitamin B1 that may be effective for rough skin:
Lamb meat, supper, salmon roe, paste, green peas, sesame seeds, red beans, pork liver, beef liver, eel, dried shiitake mushrooms, green soybeans, chestnuts, wheat germ, green tea, pork, yellowtail, how much, oyster mushrooms, pine nuts, soy beans , Wheat, yolk, chicken liver, tarako, hijiki, enoki mushrooms, sunflower seeds, broad beans, brown rice, black rice. Foods containing vitamin B2 that may be effective for rough skin: cheese, beef liver, dojo, liver liver, dried shiitake mushrooms, parsley, pine nuts, egg yolk, sea urchin, flatfish, rape blossoms, shimeji, natto, pork liver, Yellowtail, paste, jellyfish, shiso, broad bean, green tea, chicken liver, flounder, eel, maitake, moheroya, ashitaba, wheat germ, black rice. Foods containing vitamin B6 that may be effective for rough skin: wheat germ, walnuts, parsley, avocado, flying fish, beef liver, pork liver, red beans, sesame, me cabbage, banana, strawberry, egg yolk, broad bean, chili, moheroya, glue , Salmon, tuna, chicken liver, soy, garlic, leek, sardine, saury. Food containing bifidobacteria that seems to be effective for rough skin: Yogurt. Foods containing protamine that may be effective for rough skin: Shirako no Shirako, Shirako no Shirako, sea urchin. Foods that contain β-carotene that may be effective for rough skin: Asatsuki, Ashitaba, Okra, Japanese radish, Turnip leaf, Pumpkin, Watercress, Kale, Komatsuna, Shiso, Spring chrysanthemum, Radish leaf, Tsurumurazaki, Rape blossom, Lala , Carrot, parsley, leaf onion, broccoli, broccoli sprout, spinach, honey bee, moheroya, watermelon, loquat, hijiki, sea urchin, green tea. Foods containing lycopene that seems to be effective for rough skin: tomatoes and watermelons.

As described above, various materials for preventing rough skin are publicly known. However, regarding the viewpoint of cosmetics, the following can be exemplified from the viewpoint of patent literature.

Japanese Patent Application Laid-Open No. 2004-331530 (Patent Document 1) discloses that when applied directly to the skin as an external preparation, it promotes the metabolism of the skin without harming the skin, smoothes the skin, improves rough skin, and ages the skin. Provided is a cosmetic that exhibits an excellent beauty promoting effect that also serves as a prevention. For skin or hair cosmetic bases, spinach (Akazaceae, scientific name: Spinacia
Blend with extract or press from Oleracea L). It is disclosed.

Japanese Patent Application Laid-Open No. 2004-323466 (Patent Document 2) discloses a group consisting of hydrolyzing enzymes, moss and lactic acid bacteria in Sendangusa genus plants, particularly Bidence pylosa alone or in advance mixed with ginger. Disclosure that a cosmetic product comprising at least one selected product provides a cosmetic product that has an enhanced anti-inflammatory effect in atopic dermatitis, an improved itching effect, an improved odor, and a moist feeling Has been.

JP 2004-284962 A (Patent Document 3) considers deterioration of the barrier function in the stratum corneum as one of the causes of skin roughening, and recovery of the barrier function in the stratum corneum improves the skin external preparation. It has become one of the development themes. The barrier function in the stratum corneum is retained by keratin SS bonds. Therefore, it is generally said that this bond disorder and free SH groups increase are an indicator of the deterioration of the barrier function in the stratum corneum. Therefore, a skin roughening external preparation characterized by containing alum, calcium salt, and magnesium salt strengthened the SS bond of keratin and showed an excellent effect of improving the stratum corneum barrier function. It is disclosed.

Japanese Patent Application Laid-Open No. 2004-256485 (Patent Document 4) includes a scientific name: Curcuma.
A whitening agent comprising a plant of zeodoaria (Berg) Roscoe (Indonesia name: Temu Putih) or an extract thereof. Scientific name: Curcuma zedoaria (Berg) Roscoe (Indonesian name: Temu)
A rough skin improving agent comprising a plant of Putih) or an extract thereof. Scientific name: Curcuma zedoaria (Berg) Roscoe (Indonesian name: Temu)
A skin external preparation characterized by containing a plant of Putih) or an extract thereof. Furthermore, the scientific name: Uncaria gambil (Hunter) Roxb. A skin external preparation containing a plant of Indonesian name: Gambir or an extract thereof. Is disclosed.

Japanese Patent Application Laid-Open No. 2004-250372 (Patent Document 5) discloses that a component effective for skin beautification is selected from the group consisting of a biological collagen synthesis promoter, an abnormal protein removing agent, a female hormone-like agent, and a moisturizing agent. Or the drink which is 2 or more types. A beverage characterized in that the biological collagen synthesis promoter is a degradation product of collagen and / or gelatin. A beverage in which the abnormal protein remover is one or more selected from the group consisting of soybean-derived saponins, kale plants or extracts thereof. A beverage characterized in that the female hormone-like agent is isoflavone. A beverage in which the humectant is one or more selected from the group consisting of ceramide, glucosamine, N-acetylglucosamine, hyaluronic acid, and chondroitin. Furthermore, the drink containing an antioxidant. A beverage characterized by having at least one alcohol. A skin aging prevention / improvement agent and / or rough skin prevention / improvement agent kit characterized by a combination of a beverage and an external preparation containing soybean germ extract. Is disclosed.

Japanese Patent Application Laid-Open No. 2004-238318 (Patent Document 6) describes a skin external preparation for improving rough skin, which comprises dextran or a derivative thereof and a sugar alcohol having 4 to 6 carbon atoms as active ingredients. An anti-aging skin external preparation comprising dextran or a derivative thereof and a sugar alcohol having 4 to 6 carbon atoms as active ingredients. A topical skin preparation whose sugar alcohol is xylitol or erythritol. Is disclosed.

Japanese Patent Application Laid-Open No. 2004-217621 (Patent Document 7) includes a composite powder in which zinc oxide is coated on the surface of a lipophilic base powder and an oil component in which the composite powder is dispersed. An oily skin external preparation, wherein the ζ potential of the powder is a negative value at pH on the skin. In the cosmetic, at the time of oil dispersion, the coverage of zinc oxide with respect to the total surface area of the lipophilic base powder is preferably 1 to 90%. In the cosmetic, it is preferable that the lipophilic base powder swells during oil dispersion. The cosmetic can be used as a rough skin improving agent and a sensitive skin care agent. It is disclosed.

JP 2004-155678 A (Patent Document 8) discloses an extract of a plant belonging to the family Thygonaceae as a result of extensive research to obtain a component having excellent moisture retention and an excellent effect of improving and preventing rough skin. It has been disclosed that a composition suitable for external use, a moisturizing agent, and a rough skin improving agent, which are excellent in a moisturizing effect and a rough skin improving effect, can be obtained by containing.

JP 2004-155677 discloses (Patent Document 9), excellent moisture retention, as a result of intensive studies to obtain an excellent component in rough improvement and prevention effect, Molina genus (Morina), Puterokefarusu genus (Pterocephalus) A skin external preparation for moisturizing which contains an extract of one or more kinds of plants selected from plants belonging to any of the genus Triplostegia and has excellent moisturizing effect and rough skin improving effect And it has been disclosed that an external preparation for skin roughening can be obtained.

In JP 2004-149444 A (Patent Document 10), in order to find an active ingredient excellent in moisture retention and prevention and improvement of rough skin, as a result of intensive research on various substances, as a result, Stachyuraceae ) A plant extract was found. The stachyuraceae (Stachyuraceae) plant extracts by incorporating the skin external preparation excellent in moisture retention, can be obtained skin external agent exhibiting an excellent effect on the prevention and amelioration of skin roughness. It is disclosed.

In JP-A-2004-99503 (Patent Document 11), the present invention contains a rice extract such as white rice, black rice, red rice or the like, an HGF production promoter or anti-aging of skin, improvement of rough skin and Provides hair growth cosmetics. Skin anti-aging, rough skin improvement, and hair-growth cosmetics characterized by containing extracts of white rice, black rice, red rice, etc. were excellent in stability and showed excellent effects on the skin. It is disclosed.

Japanese Patent Application Laid-Open No. 2004-91351 (Patent Document 12) provides a whitening agent or an anti-skinning agent that has excellent whitening and anti-skinning effects and does not deteriorate in the preparation, and this A topical skin preparation that is stable over time, whitening, and excellent in preventing skin roughness. A whitening agent containing, as an active ingredient, a liquid (yokuinin water) obtained by steam distillation of an extract extracted from yokuinin with water. Also, an anti-skinning agent containing Yokuinin water as an active ingredient. Furthermore, the skin external preparation containing this. Furthermore, a topical skin preparation containing yokuinin water and one or more specific medicinal agents such as ascorbic acid, glycyrrhizic acid and derivatives thereof, and salts thereof. Is disclosed.

JP-A-2004-83541 (Patent Document 13) describes the outside of the skin that is excellent in use feeling as well as moisturizing and roughening effect. A skin external preparation containing an alkylene oxide derivative represented by the general formula (I). R ¹ O — [(AO) _m (EO) _n ] —R ² (I) (where AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and R ¹ and R ² are the same. Alternatively, it may be a hydrocarbon group having 1 to 4 carbon atoms or a hydrogen atom which may be different.) The alkylene oxide derivative (I) has a moisturizing effect and a rough skin improving effect, a stickiness improving effect and a percutaneous absorption promoting effect. It is disclosed.

Japanese Patent Application Laid-Open No. 2004-75661 (Patent Document 14) discloses a novel means for promoting repair and remodeling of the skin basement membrane structure and an external preparation for skin, and sufficient formation of a basement membrane in the production of artificial skin. Provide new means to achieve. Provided are an epidermal basement membrane structure formation promoter and an external preparation for skin, each of which comprises a serine protease inhibitor and optionally an extracellular matrix protein production promoter as an epidermal basement membrane component. Furthermore, as a method for producing artificial skin having a well-formed basement membrane, a serine protease inhibitor, optionally an extracellular matrix protein production promoter of epidermal basement membrane components, and an inhibitor of matrix metalloprotease are mixed. A medium for artificial skin culture containing the above and a method for producing the same are provided. It is disclosed.

Japanese Patent Application Laid-Open No. 2004-67676 (Patent Document 15) discloses a composition comprising an oxidation-sensitive active substance selected from ascorbic acid and derivatives thereof showing good cosmetic properties with respect to both feel and resistance, Provision of a composition that does not require specific measures, improves the synthesis of ceramide and the barrier function of the skin, and maintains the activity of the active substance to improve keratinocyte differentiation. In a physiologically acceptable medium comprising an aqueous phase, at least one oxidation-sensitive hydrophilic active substance selected from ascorbic acid and its derivatives, one or more maleic anhydride comonomers and vinyl acetate, vinyl alcohol , Vinylpyrrolidone, an olefin containing 2 to 20 carbon atoms, and at least one maleic anhydride copolymer containing one or more comonomers selected from styrene, comprising the synthesis of epidermis ceramide Cosmetic use of the composition for improving and / or improving the barrier function of the skin. Is disclosed.

Japanese Patent Application Laid-Open No. 2004-59440 (Patent Document 16) has an excellent preventive / ameliorating effect on skin diseases, mild and severe rough skin, and rough skin having a strong mucosal repair effect on damaged mucous membranes. Prophylactic and mucosal repair agents are provided. A rough skin prevention and mucosal repair agent containing pectin as an active ingredient. Is disclosed.

Japanese Patent Application Laid-Open No. 2004-35454 (Patent Document 17), when applied directly to the skin as an external preparation, promotes the metabolism of the skin without harming the skin, smoothes the skin, improves acne, rough skin, and the skin The cosmetics which show the outstanding beauty promotion effect which served as prevention of aging of the skin are provided. A cosmetic comprising morinda citrifolia (scientific name: Morinda Citrifolia L, Japanese name: Yaeyama Aoki, also known as Noni) in a skin or hair cosmetic base. Cosmetics wherein the fruit is an extract from fresh fruit, a pressed liquid, or a dry powder from dried fruit. Is disclosed.

JP 2004-35422 (Patent Document 18) provides a new use of bismuth subgallate in preventing and / or reducing skin deterioration. Disclosed is a new use of bismuth subgallate for use in preventing and / or reducing skin degradation. Also disclosed is the synergistic efficacy of bismuth subgallate in combination with borneol in preventing and / or reducing skin degradation.

JP-A-2004-26739 (Patent Document 19) relates to a cosmetic that can keep the skin healthy, and has an excellent improvement effect against dullness and darkness, and further excellent skin roughness prevention effect, keratin improvement effect, Quercetin or a quercetin derivative is blended as a cosmetic having an anti-aging effect and a skin-beautifying effect. It is disclosed.

JP-A-2004-18497 (Patent Document 20) finds a cell activator and an antioxidant having excellent effects, and further blends the cell activator and the antioxidant as active ingredients so that the skin can be treated. Provided is a skin external preparation having an excellent effect in preventing or improving aging and rough skin. A Cassytha L. plant extract having an activation effect and an antioxidant effect on dermal fibroblasts and epidermal cells is used as a cell activator and an antioxidant. Moreover, in order to prevent or improve skin aging and rough skin, a genus Cassytha L. is added to a skin external preparation as a cell activator and an antioxidant. It is disclosed.

Japanese Patent Application Laid-Open No. 2004-10559 (Patent Document 21) has a cell activator having an activation action of dermal fibroblasts and epidermal cells, an antioxidant, and an effect excellent in improving skin aging symptoms and rough skin. Provide skin external preparations and foods to exert. A cauler paracemosa algae extract having an activation effect on dermal fibroblasts and epidermal cells is used as a cell activator. Further, it used as an antioxidant to Kaurerupa racemosa (Caulerpa racemosa) algal extract having antioxidant effect. Furthermore, in order to improve aging symptoms and rough skin such as wrinkles, tarmi, and reduction of skin firmness, the skin extract of Caulerparacemosa (Cauler racemosa ) algae extract, which has dermal fibroblast and epidermal cell activation and antioxidant effects It mix | blends with an external preparation and a foodstuff. It is disclosed.

Japanese Patent Application Laid-Open No. 2004-10557 (Patent Document 22) finds a cell activator and an antioxidant having an excellent effect, and further blends the cell activator and the antioxidant as active ingredients, so that Provided is a skin external preparation having an excellent effect in preventing or improving aging and rough skin. Rhizophora L. plant extract having dermal fibroblast and epidermal cell activation and antioxidant effects is used as a cell activator and antioxidant. In addition, in order to prevent or improve skin aging and rough skin, Rhizophora L. plant extract is added to a skin external preparation as a cell activator and an antioxidant. It is disclosed.

JP-A-2003-342148 (Patent Document 23) finds a cell activator and an antioxidant having an excellent effect, and further blends the cell activator and the antioxidant as active ingredients, whereby Provided is a skin external preparation having an excellent effect in preventing or improving aging and rough skin. A Bruguiera plant extract having an activation effect and an antioxidant effect on dermal fibroblasts and epidermal cells is used as a cell activator and an antioxidant. Moreover, in order to prevent or improve skin aging and rough skin, a Brugiera plant extract is blended in a skin external preparation as a cell activator and an antioxidant. It is disclosed.

Japanese Patent Application Laid-Open No. 2003-342119 (Patent Document 24) promotes the metabolism of skin without harming the skin when applied directly to the skin as an external preparation, and improves spots, acne, rough skin and prevents skin aging. The cosmetics which show the outstanding beauty promotion effect which also served as the are provided. It is disclosed that a dry powder of a fruit of a vine moth (Cucurbitaceae, scientific name (Momordica Charantia L bitter melon)) is incorporated into a cosmetic base for skin or hair.

Japanese Patent Application Laid-Open No. 2003-267852 (Patent Document 25) discloses a cell activator having an activation action of dermal fibroblasts and epidermal cells, and skin exhibiting excellent effects in preventing and improving skin aging symptoms and rough skin. Provide external preparations. As a cell activator, a mock extract having an activating effect on dermal fibroblasts and epidermal cells is used. In addition, in order to prevent and improve aging symptoms and rough skin such as wrinkles, tarmi, and reduction of skin firmness, a mok extract having an activating effect on dermal fibroblasts and epidermal cells is added to an external preparation for skin. It is disclosed.

In JP2003-212785A (Patent Document 26), a squeezing step of squeezing the fruits of the plant belonging to the genus Solanum from the stem, a separation step of separating the squeezed juice into a liquid and a solid, A liquid eggplant extract produced through a preservative pre-addition step of adding a preservative to the separated liquid and a post-heat treatment step of heat-treating the preservative-added liquid. The preservative contains at least one of alcohol, wood vinegar, bamboo vinegar, and isodine, and is added in a range of 0.1 to 1 with respect to the liquid or concentrate 1 by weight. The eggplant extract according to any one of claims 1 to 4, wherein the eggplant extract is used. The plant belonging to the genus Solanum is an eggplant, a coral, a cypress, a violet shower, a pepino, a Solanum lannetetti, a horned fox face, a dog dung beetle, a porcupine, a chickweed, or a chickfish. The eggplant extract according to any one of 6. Liquid or ointment eggplant extract is used and carbonized to treat skin diseases such as athlete's foot, sputum, atopy, herpes, pimples, eczema, rough skin, or tropical and cultured fish diseases The eggplant extract according to any one of claims 1 to 7, wherein the eggplant extract is used as a therapeutic agent for periodontal disease. Is disclosed.

In JP2003-12558A (Patent Document 27), an adsorbent powder that sucks or adsorbs a specific enzyme and an action powder having an inhibition or activation characteristic of the enzyme are blended in a solidifying base. A solidifying skin external preparation characterized by the above. The external preparation for skin, wherein the adsorbed powder is a powder having a negative ζ potential at pH 7.5, the solidifying external preparation for skin. The external preparation for skin, wherein the adsorbed powder is a powder having a ζ potential of -20 mV or less at pH 7.5, the solidifying external preparation for skin. In a skin external preparation, the specific enzyme is a plasminogen activator, and the working powder is a powder capable of releasing a metal compound or metal ion having a plasminogen activator inhibitory action. Skin external preparation. In the external preparation for skin, the adsorbed powder and working powder, or the adsorbed powder, working powder and base powder are premixed before mixing with the solidifying base, and the adsorbed powder and working powder are directly Alternatively, the solidifying skin external preparation obtained by being disposed in the vicinity of the base powder and then mixed with the solidifying base. In the external preparation for skin, the working powder is a metal or a metal compound capable of releasing zinc ions, and the adsorbed powder is silica, talc or mica. A solidifying skin external preparation characterized by having an inhibition rate of plasminogen activator of 40% or more in the external preparation for skin. The inhibition rate of plasminogen activator is measured by the following method. Measurement of inhibitory action of plasminogen activator activity A buffer containing 0.1% of a test sample and a double-stranded urokinase type plasminogen activator (30 U / mL) was evaluated by a synthetic substrate degrading activity. A solidifying skin external preparation, characterized in that the external preparation for skin is used for improving rough skin. A solidifying skin external preparation characterized in that the external preparation for skin is for sensitive skin. Is disclosed.

JP-A-2002-356416 (Patent Document 28) discloses a water-in-oil emulsified cosmetic for preventing rough skin, containing 0.1-20% organopolysiloxane elastomer spherical powder and 3-25% glycerin. The water-in-oil emulsified cosmetic for preventing rough skin according to claim 1, wherein the average particle diameter of the organopolysiloxane elastomer spherical powder is 1.0 to 10.0 µm. A water-in-oil emulsified cosmetic for preventing rough skin, wherein the mass ratio of the organopolysiloxane elastomer spherical powder and glycerin is organopolysiloxane elastomer spherical powder: glycerin = 1: 2-3. Is disclosed.

JP 2002-302448 A (Patent Document 29) provides an external preparation for skin having an excellent moisture retention function and an effect of improving and preventing rough skin. It is disclosed that it has been found that the above problems can be solved by providing an external preparation for skin containing an oligosaccharide obtained by carrageenan degradation and / or a salt thereof as an active ingredient.

JP 2002-255728 A (Patent Document 30) is blended with various drugs and cosmetics, and is formulated with an anti-rough agent that effectively suppresses and prevents rough skin, and lysozyme chloride that provides an anti-skin effect and the like. To provide cosmetics for direct use on skin in the form of lotions, emulsions, gels or creams. The rough skin prevention agent contains lysozyme chloride as an active ingredient, and the cosmetics include lysozyme chloride, an antioxidant, edetic acid, edetate, sodium gluconate or a mixture thereof, and if necessary an inorganic thickener, Including a cationic polymer thickener, a nonionic polymer thickener or a mixture thereof, having a pH of 3.5 to 6.5, and having a form of lotion, emulsion, gel or cream. Directly used or contains lysotium chloride in an amount exceeding 0.8% by mass relative to the total amount of the cosmetic, has a pH of 3.5 to 6.5, and has a form of lotion, emulsion, gel or A cream that is used directly on the skin. It is disclosed.

Japanese Patent Application Laid-Open No. 2002-241295 (Patent Document 31) provides a skin external preparation characterized by containing an extract of a cat beard and / or a betel wax. A skin external preparation characterized by containing an extract of a cat beard and / or a betel wax. The extract of the present invention had excellent active oxygen scavenging action, histamine release inhibiting action, hyaluronidase inhibitory action and antibacterial action, and was excellent in stability. Furthermore, the external preparation for skin containing these extracts was safe and excellent in the effects of preventing skin aging, rough skin and acne. It is disclosed.

JP 2002-226356 A (Patent Document 32) has a moisturizing effect and a hair protecting effect, and prevents, reduces or improves dryness, rough skin, cracks, red spots, and inflammatory diseases on the skin. In addition, the present invention provides a cosmetic composition that is effective for drying, softening, split ends, broken hair, gloss, and the like. A moisturizing agent, a rough skin improving agent, a hair protecting agent, and a cosmetic composition containing these are characterized by containing collagen obtained by extraction from a pigmentless fish skin. It is disclosed.

Japanese Patent Application Laid-Open No. 2002-212050 (Patent Document 33) discloses that when applied directly to the skin as an external preparation, it promotes skin metabolism without harming the skin, smoothes the skin, acne, rough skin and aging of the skin. Provided is a cosmetic that exhibits an excellent beauty promoting effect that also serves as a prevention. The skin or hair cosmetic base, Momordica (Cucurbitaceae, scientific name (formulated with extract or squeezed liquid from the fruit of Momordica charantia L bitter melon (bitter melon)). It is disclosed.

JP-A-2002-193820 (Patent Document 34) has a sufficient amount of a medicinal component, which is produced when a medicinal component intended to prevent rough skin is blended, or is insufficient to obtain a medicinal effect. To provide an external preparation for skin, which is improved in that it lacks stability or deteriorates the feeling of use when added. Agave salmiana, Agave scalbra
skin external preparations containing as an active ingredient an agave extract obtained by extracting an agave genus plant selected from scarbra), agave celsii or agave tequilana, and the agave extract (component ( A skin external preparation composition comprising a)) and a drug (component (b)) selected from a humectant, an antioxidant, an anti-inflammatory agent, a cell activator, and an ultraviolet light inhibitor. Is disclosed.

Japanese Patent Laid-Open No. 2002-187838 (Patent Document 35) contains a fermentation product obtained by allowing a microorganism to act on a bean extract and one or more of vitamin A and / or its derivatives. A topical skin preparation.
An external preparation for skin which has a cell activation effect.
An external preparation for skin having an effect of promoting hyaluronic acid production. An external preparation for skin that is an agent for preventing and improving rough skin. A skin external preparation, wherein the microorganism is one or more microorganisms selected from lactic acid bacteria or bifidobacteria. An external preparation for skin that is a cosmetic. Is disclosed.

Japanese Patent Application Laid-Open No. 2002-121108 (Patent Document 36) discloses a skin external preparation for improving rough skin, comprising one or more selected from xylitol, arginine, and trimethylglycine and ginkgo biloba extract. Is disclosed.

JP 2002-87925 A (Patent Document 37) includes (1) a hydrolyzate of sponge protein and (2) trimethylglycine and / or N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylic acid. An external preparation for skin that is excellent in preventing rough skin, improving rough skin, and keeping skin moisturized. Is disclosed.

Japanese Patent Laid-Open No. 2002-80359 (Patent Document 38) describes skin diseases in which an activity change of serine protease such as plasmin and / or plasminogen activator (PA) is observed in the affected area, for example, contact Skin dermatitis, psoriasis, pemphigus vulgaris, congenital chicken pox, etc., skin external agents that have an effect of improving / preventing rough skin caused by dryness or cleaning agents, and skin external preparations for improving rough skin, Provided are a protease inhibitor, an antiplasmin agent, and an acne improving / preventing agent and an external skin preparation for improving acne that have an effect of improving / preventing acne and pimples while promoting recovery of acne. Aspartic acid-N, N-diacetic acid or a salt thereof is added. It is disclosed.

JP-A-2002-80338 (Patent Document 39) discloses a skin anti-aging agent for preventing aging and for improving rough skin, which is effective in preventing aging by preventing skin sag and loss of gloss in addition to preventing rough skin and improving rough skin. An external skin preparation is provided. Vitamin A or a derivative thereof, curcumin or a salt thereof or a derivative thereof, Astragalus sinicus Linne (Leguminosae), tormentilla (Potentilla tormentilla Schrk (Rosaceae)) or Thymus serpyllum L. or a solvent extract thereof Such a gelatinase activity inhibitor is blended as an active ingredient. It is disclosed.

Japanese Laid-Open Patent Publication No. 2002-3373 (Patent Document 40) contains a basic amino acid or a salt thereof or tranexamic acid, and a sugar alcohol having 4 to 6 carbon atoms as an active ingredient, for improving rough skin. Topical agent. A skin external preparation for anti-aging, comprising a basic amino acid or a salt thereof or tranexamic acid and a sugar alcohol having 4 to 6 carbon atoms as active ingredients. A topical skin preparation whose sugar alcohol is xylitol or erythritol. Is disclosed.

Japanese Unexamined Patent Publication No. 2002-3359 (Patent Document 41) discloses an external preparation for skin roughening characterized by containing vitamin A or a derivative thereof and a sugar alcohol having 4 to 6 carbon atoms as active ingredients. A skin external preparation for anti-aging, comprising vitamin A or a derivative thereof and a sugar alcohol having 4 to 6 carbon atoms as active ingredients.
A topical skin preparation whose sugar alcohol is xylitol or erythritol. A skin external preparation, wherein the amount of vitamin A or its derivative is 0.001 to 1.0% by weight and the amount of sugar alcohol having 4 to 6 carbon atoms is 0.001 to 20.0% by weight. Is disclosed.

JP-A-2002-3358 (Patent Document 42) includes one or more kinds of plant extracts selected from Clara, Asenyaku, Clove, Yukinoshita, Hop, Rosemary, Shikon, Hypericum, Hypericum and Cha. An external preparation for skin roughening characterized by containing tranexamic acid as an active ingredient. One or more of plant extracts selected from Clara, Asenyaku, Clove, Yukinoshita, Hops, Rosemary, Shikon, Hypericum, Hypericum perforatum and Cha are combined with tranexamic acid as an active ingredient. A skin preparation for anti-aging. The skin external preparation whose compounding quantity of a plant extract is 0.00001 to 0.1 weight% as dry solid content, and the compounding quantity of tranexamic acid is 0.01 to 10.0 weight%. Is disclosed.

JP 2001-342112 A (Patent Document 43) suppresses the production of melanin and is effective in preventing pigmentation / stain / freckle / liver spots after sunburn, contact dermatitis, psoriasis, The present invention provides an external preparation for skin having both a whitening effect and an effect of improving rough skin, which are effective in improving other skin diseases such as rough skin and rough skin. An akebi or a solvent extract thereof, and one or more plants selected from the group consisting of Choujinoki, Kay, Sagiomodaka, ginger and auren, or a solvent extract thereof are blended as active ingredients. It is disclosed.

JP 2001-335458 A (Patent Document 44) suppresses the production of melanin and is effective in preventing pigmentation / stain / freckle / liver spots after sunburn, as well as contact dermatitis, psoriasis, The present invention provides an external preparation for skin having both a whitening effect and an effect of improving rough skin, which are effective in improving other skin diseases such as rough skin and rough skin. Akebi or a solvent extract thereof and one or more selected from the group consisting of xylitol, mannitol, and erythritol are blended as active ingredients. It is disclosed.

JP-A-2001-335454 (Patent Document 45) has skin roughening prevention / improvement effect, keratin improvement effect, moisturizing effect, and prevention of loss of beam by promoting hyaluronic acid production of skin and improving collagen metabolism. To provide an agent for preventing and improving rough skin, which is effective in preventing skin aging. A rough skin prevention and improvement agent containing isoflavone aglycone as an active ingredient. Is disclosed.

JP 2001-278797 A (patent document 46) inhibits metabolism of arachidonic acid, in addition to rough skin symptoms and inflammation caused by various skin diseases such as atopic dermatitis, contact dermatitis, eczema, psoriasis, Provided are a skin external preparation for preventing rough skin, an anti-inflammatory agent and an arachidonic acid metabolism inhibitor, which are effective in preventing and improving rough skin and roughness of healthy people. Bold (scientific name: Peumus boldus), Cullen (scientific name: Psoral)
pubescens Pers.) and one or more plant extracts selected from Latania (scientific name: Krameria triandra) are blended as active ingredients. It is disclosed.

JP 2001-261545 A (Patent Document 47) has a platelet activating factor antagonistic action, in addition to rough skin symptoms due to various skin diseases such as atopic dermatitis, contact dermatitis, eczema, psoriasis, Provided is a skin external preparation for preventing rough skin, which has an effect of improving / preventing rough skin and rough skin of healthy people. Zingiberaceae Zingiber plant, Temu Kunci (Indonesia name: Temu Kunci, scientific name: Boesenbergia pandurataSchl.) Extract, Zingiberaceae Kaempferia plant, Knei Pepeto (Indonesian name: Kuney pepet, scientific name: Kaempferia angustifolia) or extract of Menilan (Indonesian name: Menilan, Scientific name: Phyllanthus niruri L.), a plant of the Euphorbiaceae genus Phyllanthus Blend as an ingredient. It is disclosed.

JP 2001-151659 A (Patent Document 48) is to provide a highly safe plant-derived protease inhibitor and a skin external preparation containing the same. A protease inhibitor containing, as an active ingredient, one or more selected from plants belonging to Cyperaceae and / or Elaeocarpaceae, and an anti-rough skin external preparation containing the same. Is disclosed.

Japanese Patent Application Laid-Open No. 2001-240551 (Patent Document 49) discloses various diseases caused by serine proteases, particularly serine proteases related to fibrinolytic systems such as plasmin and plasminogen activator, particularly skin diseases. The present invention provides a serine protease activity inhibitor having an excellent effect in improving and preventing rough skin and roughness of healthy people, and a skin external preparation for improving rough skin. Calophyllum brasiliense Cambess., Myrcia sphaerocarpa DC., And Hyptis
crenata Pohl ex Benth.) Serine protease activity inhibitor containing one or two or more plants selected from among them, or a solvent extract thereof, and skin external use for improving rough skin containing the plant or the solvent extract thereof Agent. Is disclosed.

JP-A-2001-240548 (Patent Document 50) provides a plasminogen activator inhibitor that exhibits an effect of improving skin roughness with an inorganic component, a skin external preparation containing the same, and a method of improving skin roughness using the same. . A plasminogen activator inhibitor comprising one or more zinc oxides that adsorb plasminogen activator and inhibit its activity, a skin external preparation containing the same, and rough skin using the same How to improve. Is disclosed.

Japanese Patent Laid-Open No. 2001-122792 (Patent Document 51) includes a new technique that can prevent and improve various skin diseases such as pigmentation, blemishes, freckles, keratinization abnormalities, rough skin, rough skin, and skin aging after sunburn. To find the right means. 1 selected from the group consisting of a plant belonging to the genus Akagi (Bischofia Bl.), A plant belonging to the genus Ivanashi (Epigaea L.), a plant belonging to the genus Camellia (Camptotheca Decne.), And a plant belonging to the genus Ryogen (Clethra L.) It has been disclosed that it has been found that the above-described problems can be solved by providing a skin external preparation containing a seed or two or more plant extracts as an active ingredient.

JP 2001-122728 A (Patent Document 52) provides an external preparation that exerts protease inhibitory activity in the skin, that is, a protease inhibitor, focusing on the action of proteases in the skin. An extract of one or more plants selected from the group consisting of plants belonging to the genus Pistacia L., plants belonging to the genus Lindera Thunb. And plants belonging to the genus Sapium P.Br It has been disclosed that it has been found that the above-mentioned problems can be solved by providing a protease inhibitor containing as an active ingredient.

Japanese Patent Application Laid-Open No. 2001-81008 (Patent Document 53) has an excellent effect of preventing rough skin and improving rough skin, and also has an effect of preventing aging by preventing sagging and loss of skin and preventing aging. An anti-aging skin external preparation is also provided. One or two extracts of a plant selected from Ichajak, Hypericum, Jujuk, Atlantic mint, Green mint, Gentian pepper, Buttons, Paramecium hops, Arnica, Roman chamomile, Sanosano, Dokudami, Kawara mugwort, apricot, grape leaves, safflower and birch More than seeds and a sugar alcohol having 4 to 6 carbon atoms such as xylitol and erythritol are blended. It is disclosed.

Japanese Patent Application Laid-Open No. 2001-39854 (Patent Document 54) has various useful effects such as whitening, roughening improvement / prevention, and moisturizing that have been conventionally desired in the art such as cosmetics, quasi-drugs, and pharmaceuticals. Provision of topical skin preparations. A topical skin preparation containing an extract of a plant belonging to the genus Lepidium of the family Brassica (Cruciferas) is used. In particular, an external preparation containing Lequadium meyenii Walp is used. It is disclosed.

Japanese Patent Application Laid-Open No. 2000-344651 (Patent Document 55) has an excellent effect of preventing aging by preventing skin sagging and loss of gloss by having an excellent effect of preventing rough skin and improving rough skin. An external preparation for skin is provided. Lysolecithin and at least one compound selected from serine, alanine and trimethylglycine are blended. It is disclosed.

Japanese Patent Application Laid-Open No. 2000-344650 (Patent Document 56) has an excellent effect of preventing aging by preventing skin sagging and shining by having an excellent effect of preventing rough skin and improving rough skin, without causing side effects. An external preparation for skin is provided. Phytosterol and at least one compound selected from serine, alanine and trimethylglycine are blended. It is disclosed.

Japanese Unexamined Patent Publication No. 2000-247907 (Patent Document 57) describes a skin exfoliation accelerator useful for promoting physiological exfoliation of skin and a healthy skin, and a skin external preparation such as skin cosmetics. The present invention provides a whitening cosmetic that is effective in removing melanin contained in an old stratum corneum by accelerating turnover speed and quickly removing old stratum corneum and restoring beautiful white skin. An exfoliating accelerator composed of apricot extract, rice bran extract, carrot extract and other substances that enhance the activity of aspartic proteinase in the skin, and further an exfoliating accelerator combined with a substance that enhances the activity of chymotrypsin-like proteinase in the skin. Various skin external preparations and skin cosmetics characterized by containing an accelerator, and a method for promoting exfoliation by enhancing the activity of aspartic proteinase in the skin. Is disclosed.

Japanese Unexamined Patent Publication No. 2000-247866 (Patent Document 58) provides a skin external preparation excellent in skin care effect. An external preparation for skin comprising (1) creatinine and / or creatine and (2) an active substance which is a medicinal substance and / or a physiologically active substance. Is disclosed.

JP 2000-212059 A (Patent Document 59) provides a cosmetic that is excellent in endothelial cell proliferation effect and angiogenesis effect and has a high effect of improving rough skin. Amihanaiguchi, Shironumeiuchi, Hanaiuchi, Utsurobenihanaiguchi, Amanita, Kinoboriguchi, Ezokogi, Yellow spirit, Gentian, Senna, Eucommia, Daiou, Merirot, Yokuinin, Japanese wolfberry, Toki, Chichi, Sanshishi, Liquorice, Carrot, Red ginseng A cosmetic comprising an extract selected from purple root and symbidium. It is a cosmetic that is excellent in angiogenic endothelial cell proliferation action and angiogenesis effect and has a high effect of improving rough skin. It is disclosed.

Japanese Patent Application Laid-Open No. 2000-191493 (Patent Document 60) shows an excellent effect in improving acne and rough skin when applied directly to the skin as an external preparation, and activates the function of the skin without harming the skin. Provide medicinal cosmetics that help skin regeneration. To the cosmetic base, ginger (Aipinia)
speciosa K. schum) leaves or stems are mixed with the extract or press. It is disclosed.

Japanese Unexamined Patent Publication No. 2000-95667 (Patent Document 61) provides a skin external preparation having a high effect of preventing rough skin and improving rough skin. A leaf and / or fruit extract of tea tree (Thea sinensiss Linne) is mixed with one or more compounds selected from serine, alanine, trimethylglycine, edetate and trisodium ethylenediaminehydroxyethyl triacetate. It is disclosed.

Japanese Patent Application Laid-Open No. 11-269029 (Patent Document 62) has an excellent effect in improving / preventing various skin diseases, rough skin, roughness, etc., and also prevents skin aging and prevents sagging. Provided is an external preparation for skin that is also excellent in effect. An extract of the beech family Beech genus plant, a specific 1-acyl lysophospholipid, and an extract of Asen medicine are blended. It is disclosed.

Japanese Patent Application Laid-Open No. 11-269028 (Patent Document 63) provides an external preparation for skin having excellent effects on improving rough skin and having excellent effects on improving and preventing various skin diseases, rough skin, roughness and the like. A mixture of an extract of a plant of the family Raffidae such as roots and / or stems (prevented) of a big oak and an amino acid or a derivative thereof. It is disclosed.

In JP-A-11-209298 (Patent Document 64), in addition to rough skin symptoms caused by various skin diseases such as contact dermatitis and psoriasis, rough skin improvement has an effect of improving / preventing rough skin and roughness of healthy persons. An external preparation for skin is provided. An external preparation for skin roughening containing a solvent extract of Cuachalalate (scientific name: Juliania adstringens). A protease inhibitor comprising the solvent extract. Is disclosed.

Japanese Patent Application Laid-Open No. 11-60436 (Patent Document 65) provides a cosmetic for improving rough skin, which can improve rough skin, in particular roughening of the horny skin, smoothness, smoothness, and smooth skin. L-alanine, D-alanine or DL-alanine is blended as an active ingredient. It is disclosed.

Japanese Patent Application Laid-Open No. 11-60435 (Patent Document 66) provides a cosmetic for improving rough skin, which can improve rough skin, in particular roughening of the horny skin, smoothness, smoothness and smooth skin.
L-serine, D-serine or DL-serine is blended as an active ingredient. It is disclosed.

Japanese Patent Application Laid-Open No. 11-35443 (Patent Document 67) has a novel moisturizing agent, skin roughening agent, and high safety, excellent moisturizing effect and skin roughening effect, and excellent usability. To provide an external preparation for skin. A moisturizing agent, an external preparation for skin, and an external preparation for skin containing the same, comprising a lower alkyl tetritol ether represented by the following general formula (1) as an active ingredient. A-Rn
(1) (A represents a tetritol residue excluding a hydrogen atom n, R is an alkyl group having 1 to 4 carbon atoms, and any of a linear alkyl group, a branched alkyl group, an unsaturated alkyl group, and a hydroxyalkyl group may be used. Good, n represents the average degree of substitution of R and is a number in the range of 1-4.

Japanese Patent Application Laid-Open No. 10-245334 (Patent Document 68) discloses the use of extracts and fucoidans extracted from Okinawa and Itomo for cosmetics, medicinal cosmetics, and skin external preparations. Okinawa Mozuku and Ito Mozuku are special products of Okinawa Prefecture, and more than 6,000 tons are produced annually by aquaculture. From these mozukus, mucilages; extracts (solid powders) and fucoidans are produced, and these are incorporated into cosmetics, medicinal cosmetics, and skin external preparations to produce products with completely new functions. It is disclosed.

Japanese Patent Application Laid-Open No. 10-120548 (Patent Document 69) has an excellent effect of preventing rough skin, and has an excellent effect in improving and preventing various skin diseases, rough skin, roughness and the like, and is also excellent in safety. Provides a rough skin prevention agent. Squalene or partially hydrogenated squalene is blended as a main component. It is disclosed.

Japanese Patent Application Laid-Open No. 10-72333 (patent document 70) describes prevention of rough skin caused by various skin diseases such as contact dermatitis and psoriasis as well as rough skin and roughness of healthy persons. An external preparation for skin having an improving effect is provided. To provide an external preparation for skin comprising an extract of chicory (Cichorium intybus L.) root, for example, an external preparation for improving rough skin. Is disclosed.

Japanese Patent Application Laid-Open No. 10-72312 (Patent Document 71) prevents and protects against rough skin symptoms caused by various skin diseases such as contact dermatitis and psoriasis as well as rough skin and roughness of healthy people. Provision of an external preparation for skin having an improving effect. To provide an external preparation for skin comprising an acid decomposition product of inulin, particularly an acid decomposition product of inulin derived from chicory, for example, an external preparation for skin roughening. Is disclosed.

Japanese Patent Laid-Open No. 10-17461 (Patent Document 72) discloses a rough skin improvement which has an effect of improving / preventing rough skin and rough skin of healthy people, as well as rough skin symptoms caused by various skin diseases such as contact dermatitis and psoriasis. Provide topical preparations. A solvent extract of Clara (scientific name: Sophora flavescens Aiton) is added. It is disclosed.

Japanese Patent Application Laid-Open No. 9-143048 (Patent Document 73) provides a skin external preparation having a high effect of improving rough skin. A mucopolysaccharide such as hyaluronic acid and a compound represented by the general formula NH ₂ CH ₂ CH ₂ X (wherein X represents —SO ₂ H or —SO ₂ SH) are blended. Moreover, preferably glycerin is further blended. It is disclosed.

Japanese Patent Application Laid-Open No. 9-25213 (Patent Document 74) has excellent effects on lightening and whitening of pigmentation, stains, freckles, liver spots, etc. after sunburn, as well as excellent protease inhibitory action, The present invention provides an external preparation for skin that is effective in improving skin diseases, rough skin, rough skin, and the like. Buah Tempayan
An external preparation for skin containing an extract of a genus Scapium belonging to the family of Sterculiaceae such as tempayang, scientific name: Scapium affinis Pierre. Is disclosed.

Japanese Patent Application Laid-Open No. 9-20643 (Patent Document 75) has an excellent effect of improving rough skin, has an excellent effect in improving and preventing various skin diseases, rough skin, roughness and the like, and has excellent safety. Provide topical preparations. An external preparation for improving rough skin, containing an extract of Zapote (scientific name: Quararibea amazonia). Is disclosed.

Japanese Patent Application Laid-Open No. 9-20640 (Patent Document 76) has an excellent effect on improving rough skin, and has an excellent effect in improving and preventing various skin diseases, rough skin, roughness and the like, and is excellent in safety. Provide topical preparations. Cola de Caballo
De caballo, scientific name: Equisetum giganteum). Is disclosed.

Japanese Patent Application Laid-Open No. 9-20642 (Patent Document 77) has an excellent effect of improving rough skin, and has an excellent effect in improving and preventing various skin diseases, rough skin, roughness and the like, and has excellent safety. Provide topical preparations. Que Sha (Que
An external preparation for improving rough skin, containing an extract of shuar, scientific name: Buddleja L.). Is disclosed.

Japanese Patent Application Laid-Open No. 8-325135 (Patent Document 78) provides a skin external preparation having excellent skin roughness prevention and improvement effects and high safety. Adenosine triphosphate-disodium and tranexamic acid are blended, more preferably carrot extract. It is disclosed.

Japanese Patent Application Laid-Open No. 7-309710 (Patent Document 79) provides a base for external use and a rough skin prevention / improving agent having excellent usability. Teprenone (chemical name: geranylgeranylacetone) is a base for external use and a rough skin prevention agent.
By using teprenone as a base for external use, it is possible to make the external preparation have excellent specifications in terms of nobi, smooth feeling, and stickiness. Teprenone has an effect of preventing and improving rough skin, and moisturizes and softens the skin. It is disclosed.

JP-A-6-183948 (Patent Document 80) discloses a rough skin alleviator comprising a monoglyceride having a fatty acid residue having 16 to 24 carbon atoms. This rough skin alleviating agent has an excellent relaxation and improvement effect against irritation and damage to the skin, particularly rough skin caused by the use of a cleaning agent and the like, and also has a high moisturizing effect on the skin. It is disclosed.

JP-A-6-100427 (Patent Document 81) discloses a rough skin preventive agent containing a solvent extract of Aitamago. It has a strong antioxidant effect and suppresses hyaluronidase activity and stabilizes hyaluronic acid. When formulated in cosmetics, it prevents rough skin, prevents wrinkles, increases moistness, maintains skin elasticity, and keeps the skin shiny. Well. Since it has been used as a soft drink for many years, safety against human skin is guaranteed. It is disclosed.

JP-A-5-339141 (Patent Document 82) discloses a rough skin preventing agent containing an acidic heteropolysaccharide derived from a callus of a plant belonging to the genus Polyantes. This rough skin preventive agent has high adhesion to the skin, blocks external irritation to the skin, and prolongs the turnover days of the skin, thus preventing and improving rough skin, especially rough skin accompanied by inflammation. It is effective, has no irritation to the skin, and is highly safe. It is disclosed.

JP-A-5-331040 (Patent Document 83) discloses a rough skin preventive agent, a detergent, and a rough skin prevention method capable of preventing rough hands caused by detergents and permanent agents by blending a specific herbal ingredient or herbal extract. I will provide a. One or more components selected from tannin, organic acids and glycosides, or a rough skin preventing agent containing a crude drug extract containing the above components, or the above components or the detergent containing the above extract and the above components or the above How to prevent rough skin by using extract. Rough skin can be prevented by preventing the cleavage of the SS bond in the skin stratum corneum. It is disclosed.

In WO00 / 21501 (Patent Document 84), fermented soybean obtained by extracting an organic solvent from a fermentation product obtained by allowing one or more microorganisms selected from Bifidobacterium to act on a soybean extract. The present invention relates to an external preparation for skin and a cosmetic containing an extract. This external preparation is excellent in the wrinkle improving effect and the rough skin improving effect. It is disclosed.

WO97 / 02803 (Patent Document 85) is to provide a skin external preparation that can sufficiently exhibit the moisturizing action and skin improving action of a specific quaternary ammonium salt. For this purpose, the external preparation for skin according to the present invention is selected from the group consisting of quaternary ammonium salts represented by the following groove structure formula (I), vitamin Es, vitamin A derivatives and alkyl-modified carboxyvinyl polymers. And an enhancer of moisturizing function and skin improving function of the quaternary ammonium salt. Is disclosed.

JP-A-4-124118 (Patent Document 86) contains a highly safe skin external preparation for rough skin, characterized by containing erythritol and epsilon aminocaproic acid as active ingredients. Is disclosed.

Japanese Patent Application Laid-Open No. 1-254610 (Patent Document 87) contains a skin healing component obtained by removing only substances having a molecular weight of 13,000 or more from raw milk, skin healing, skin wrinkles, and the like. Fee. It contains non-fat milk produced from raw milk, casein whey obtained from skim milk, or healing ingredients for skin roughness, kojiwa, spots, etc. obtained by removing only substances with a molecular weight of 13,000 or more from cheese whey. And skin cosmetics. A method for producing a skin cosmetic, characterized in that a substance having a molecular weight of 13,000 or more is removed from raw milk selected from raw milk, skim milk, casein whey, and cheese whey by ultrafiltration. Manufacturing method. Is disclosed.

JP-A-3-7212 (Patent Document 88) contains 0.5 to 5% by weight of tranexamic acid and 5 to 20% by weight of one or more polyhydric alcohols having 3 or more hydroxyl groups in the molecule. An external preparation for rough skin, characterized by Is disclosed.

JP-A-2-196709 (Patent Document 89) discloses at least one poorly water-soluble component selected from the group consisting of polar oils, ultraviolet absorbers, flame retardants, preservatives, bactericides, oil-soluble pigments and fragrances. Is a cosmetic with excellent skin roughening prevention / improvement performance that contains a clathrate containing hydroxyalkylated cyclodextrin and its inclusion content is 25% by weight or less of the total cosmetics -Cosmetics with improved performance. Contains a clathrate containing at least one poorly water-soluble component selected from the group consisting of polar oil, ultraviolet absorber, anti-inflammatory agent, antiseptic, bactericidal agent, oil-soluble coloring agent and fragrance with hydroxyalkylated cyclodextrin A powder cosmetic excellent in rough skin prevention / improvement performance, wherein the inclusion content is 50% by weight or less of the total cosmetics. Is disclosed.

JP-A-4-305509 (Patent Document 90) contains a skin external preparation for improving rough skin, characterized in that urea is mixed with tranexamic acid, or a salt thereof, a derivative thereof, or a mixture thereof. Is disclosed.

JP-A-5-32556 (Patent Document 91) discloses an external preparation for improving rough skin or preventing skin aging containing ginkgo biloba extract and superoxide dismutase. Is disclosed.

Japanese Patent Application Laid-Open No. 6-65041 (Patent Document 92) discloses (A ₁ ) micaika extract, and (B ₁ ) yeast extract, lactic acid bacteria extract, bifidobacteria extract, bovine blood deprotein, bovine spleen extract , Reindeer muscle enzyme degradation product, chicken crown enzyme degradation product, royal jelly, pearl protein extract, adenosine triphosphate, adenosine diphosphate, adenosine monophosphate, succinic acid and derivatives thereof A rough skin improving agent. (A ₂ ) Mokka extract, and (B ₂ ) One or more selected from yeast extract, bifidobacteria extract, bovine blood deproteinized product, chicken crown enzyme degradation product, adenosine triphosphate and derivatives thereof A rough skin improving agent. (A ₃ ) Icrinin extract, and (B ₃ ) a rough skin improving agent comprising one or more selected from adenosine triphosphate, succinic acid and derivatives thereof. Is disclosed.

JP-A-2001-213754 (Patent Document 93) includes the following components (A) and (B): (A) a moisturizing component selected from amino acids or salts thereof, lactic acid or salts thereof, urea and betaine, ) Cosmetic for improving rough skin and roughness with cedrol as an active ingredient. Is disclosed.

Japanese Patent Application Laid-Open No. 10-203920 (Patent Document 94) discloses a rough skin preventing / improving cosmetic material characterized by containing an urchinaceae extract and arginine hydrochloride. A cosmetic for preventing the disappearance of skin moisture and abundant skin, characterized in that it contains an urchinaceae extract and arginine hydrochloride. Is disclosed.
JP 2004-331530 A JP 2004-323466 A Japanese Patent Laid-Open No. 2004-284963 JP 2004-256485 A JP 2004-250372 A JP 2004-238318 A JP 2004-217621 A JP 2004-155678 A Japanese Patent Application Laid-Open No. 2004-155679 JP 2004-149444 A JP 2004-99503 A JP 2004-91351 A JP 2004-83541 A JP 2004-75661 A JP 2004-67676 A JP 2004-59440 A JP 2004-35454 A JP 2004-35422 A JP 2004-26739 A JP 2004-18497 A JP 2004-10559 A JP 2004-10557 A JP 2003-342148 A JP 2003-342119 A JP 2003-267852 A JP 2003-212785 A JP 2003-12558 A JP 2002-356416 A JP 2002-302448 A JP 2002-255728 A JP 2002-241295 A JP 2002-226356 A Japanese Patent Laid-Open No. 2002-212050 JP 2002-193820 A JP 2002-187838 A JP 2002-121108 A JP 2002-87925 A JP 2002-80359 A JP 2002-80338 A JP 2002-226356 A JP 2002-3359 A JP 2002-3358 A JP 2001-342112 A JP 2001-335458 A JP 2001-335454 A JP 2001-278797 A JP 2001-261545 A JP 2001-151659 A JP 2001-240551 A JP 2001-240548 A JP 2001-122792 A JP 2001-122728 A JP 2001-81008 A JP 2001-39854 A JP 2000-344651 A JP 2000-344650 A JP 2000-247907 A JP 2000-247866 A JP 2000-212059 A JP 2000-191493 A JP 2000-95667 A Japanese Patent Laid-Open No. 11-269029 Japanese Patent Laid-Open No. 11-269028 JP-A-11-209298 Japanese Patent Laid-Open No. 11-60436 Japanese Patent Laid-Open No. 11-60435 Japanese Patent Laid-Open No. 11-35443 Japanese Patent Laid-Open No. 10-245334 Japanese Patent Laid-Open No. 10-120548 Japanese Patent Laid-Open No. 10-72333 JP-A-10-72312 Japanese Patent Laid-Open No. 10-17461 Japanese Patent Laid-Open No. 9-143048 Japanese Patent Laid-Open No. 9-25213 Japanese Patent Laid-Open No. 9-20643 Japanese Patent Laid-Open No. 9-20640 Japanese Patent Laid-Open No. 9-20642 JP-A-8-325135 JP 7-309710 A JP-A-6-183948 JP-A-6-100427 JP-A-5-339141 JP-A-5-331040 WO00 / 21501 gazette WO97 / 02803 Publication JP-A-4-124118 JP-A-1-254610 JP-A-3-7212 JP-A-2-196709 JP-A-4-305509 JP-A-4-305509 JP-A-6-65041 JP 2001-213754 A JP-A-10-203920

The following knowledge is known about the moisturizer for preventing rough skin.

The moisturizing agent is blended for the purpose of preventing moisture evaporation of the product and adjusting the moisture on the skin surface to give the skin and hair a moist and moist feeling. The moisture content of the skin stratum corneum is closely related to the maintenance of skin health and the defense function against various external stimuli, and plays a major role in the feeling of skin aging prevention, moisture and smoothness. Moisture retention of this stratum corneum is usually controlled by NMF (natural moisturizing factor) and sebum membrane, but its function easily deteriorates due to aging or external stimuli. Is one of the important effects of basic cosmetics.

As a moisturizing component that supplements moisture in the skin, components that are the same as or similar to biological components are attracting attention and applied. Therefore, amino acids, pyrrolidone carboxylic acid, lactic acid and the like which are constituent elements of NMF are used. In addition, mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, which are deeply involved in moisturizing the dermis layer, are blended as raw materials that are familiar with the skin and have a high moisture retention effect. With the advancement of biotechnology, it became possible to produce hyaluronic acid and other things that were difficult to obtain from the natural world.

Furthermore, intercellular lipids are greatly involved in the water retention of epidermal cells, and similar substances of this lipid have been developed. In addition, polyhydric alcohols such as glycerin, propylene glycol, butylene glycol, and sorbit have been used as moisturizers for a long time. These do not work well to keep moisture, but greatly affect the feeling of use. Extract components from plants are also widely used because they supplement the moisture-retaining function of the stratum corneum, create moist skin, and are effective in maintaining skin homeostasis. In addition, protein hydrolysates such as soluble collagen, urasutin and keratin, placenta extract extracted from bovine placenta extract, gastric mucosa of mammals, and glycoprotein mucin, crab and shrimp shells produced and secreted in salivary glands. Many substances such as chitin / chitosan, bifidobacteria metabolites, yeast fermentation metabolites, and yeast extracts are used as moisturizers.

About polyhydric alcohol.

Glycerol, to a lesser extent, glycerin is a natural skin component produced by the degradation of the sebum. It is a moisturizing agent that has been used for a long time and is very hygroscopic and is still used in many cosmetics. It is obtained as a by-product in the production of soap or fatty acid from animal and vegetable fats and oils, and it is a colorless, odorless viscous liquid obtained by purification such as dehydration and deodorization, and has a sweet taste. Glycerin is used as a humectant for the purpose of keeping the hardness and viscosity of the product constant over a long period of time. Also, as a softening agent for the skin, it improves the spreading and sliding of the product. It has moisture absorption, moisturizes the skin, and gives it a moist feel. However, if the amount used is increased, it will absorb the moisture of the skin and may cause the skin to become rough. Study is necessary. It was found that the keratin softening effect was enhanced by using glycerin and sodium hyaluronate in combination.

Xylitol (xylitol) is a kind of sugar alcohol and can be obtained by reduction of xylose. Self-colored, odorless crystals or crystalline powder, no smell and sweetness. Used for the medical purpose of energy and hydration in diabetics. In cosmetics, it is used in various creams, lotions, etc. as a moisturizer and a fragrance. For pharmaceuticals, it is used as a wetting agent for ointment bases and suppositories. It is applied to foods to prevent deterioration of fats and oils, to stabilize pigments, to stabilize pitamine C, to store meat, and to prevent deterioration of fish paste products.

Diglycerin, a dehydrated condensate of glycerin. Almost colorless and transparent liquid with almost no odor. Used as a humectant like glycerin.

Dipropylene glycol (DPG), a dehydration condensate of propylene glycol. It is a colorless and transparent viscous liquid with a slightly unique smell. It is widely used in cosmetics as a moisturizing agent with little stickiness to the skin and as a softening agent for improving product spreading and slipping.

Sorbitol (Sorbit) is a polyhydric alcohol widely found in animals and plants, and is found in algae, seaweed, tobacco and many fruits (apples, peaches, etc.). Industrially, it is obtained by reducing purified glucose (glucose), and has a white sweet taste and a refreshing sweetness. The hygroscopic effect is milder than other moisturizers, but also has the property of keeping moisture constant with respect to drying, so it is used in various cosmetics as a moisturizer and softener. Since it is not toxic or irritating even at high concentrations on the skin and oral mucosa, it is used instead of glycerin for brushing teeth.

DL-pyrrolidone sodium carboxylate and pyrrolidone carboxylic acid are present in the skin in the form of salt (en) and are moisturizing ingredients that play an important role in NMF (natural moisturizing factor). There is an odorless solid obtained by the dehydration reaction of glutamic acid, a kind of amino acid. When used in cosmetics, pyrrolidone carboxylic acid is used in the form of a sodium salt. This is because pyrrolidonecarboxylic acid has no hygroscopicity, but sodium salt and potassium salt have strong hygroscopicity. Sodium salt has a better hygroscopic effect than glycerin, propylene glycol and sorbitol. It is highly safe and provides excellent moisturizing and softening agents to the skin and hair, so it is used as a moisturizer for cosmetics such as creams, lotions, and emulsions, as well as soaps, toothpastes, and pharmaceuticals.

A colorless, odorless liquid obtained by synthesizing 1,3-butylene glycol (1,3BG) and acetanoldehydride and slightly sweet. Since it has moderate wettability and antibacterial activity, and does not irritate the skin, it is useful as a cosmetic. It has a refreshing feel and less stickiness than glycerin, so it is widely used as a moisturizer in various creams, emulsions, aerosol products, toothpastes, etc., and as a fragrance retention agent.

Obtained by hydrolysis of propylene glycol, propylene chlorohydrin or propane oxide. It is a colorless and odorless transparent liquid that has an appearance and characteristics similar to glycerin, but it is refreshing due to its low viscosity compared to glycerin, and it has an excellent feel to use. In addition to being used as a heat retention agent, it is also used as a solubilizer because it has excellent properties as a solvent. Also has antibacterial action.

It is a polymer of polyethylene glycol (carbowax) and ethylene oxide. It is not a uniform simple compound but a mixture of polymers having different degrees of polymerization. By the way, ethylene oxide is a volatile liquid with a strong bactericidal action, and is used in cosmetics for the introduction of polyethylene glycol. Polyethylene glycol is water-soluble and non-irritating, so it is used in creams, emulsions, soaps, shampoos, rinses, hair cosmetics, and the like.

Polyglycerin, obtained by dehydration condensation of glycerin, is a viscous liquid substance. As the degree of polymerization increases, fluidity is lost. Like glycerin, it is used as a moisturizer, modifier, and physical property improver. Moreover, it is used as a hydrophilic group of a surfactant. Examples include diglycerin, triglycerin, pentaglyserin, and decaglycerin.

A mixture of U-jelly, glycerin, carboxyvinyl polymer, sodium polyacrylate and water. A colorless and transparent jelly-like viscous liquid with almost no odor. It is a water-soluble jelly-like component that combines high moisture retention land and high water retention. Once water is included, it works to keep moisture for a long time.

About biological moisturizing ingredients.

NMF (white moisturizing factor), NMF refers to a natural moisturizing factor sandwiched between intercellular lipids in the horny skin. The reason why the skin remains moist is that the sebum membrane has a moisture evaporation inhibiting action and the stratum corneum of the epidermis has the ability to retain moisture. A natural heat-retaining component in which this stratum corneum exhibits water retention ability is called NMF. NMF has the largest free amino acids at 40%, and when amino acid metabolites such as pyrrolidone carboxylic acid and urea are added to it, amino acids account for 60% of the composition of NMF. When this NMF decreases, the skin becomes dry and rough. In order to prevent or improve this, it is the humectant that plays a role in supplementing the decreased NMF.

It is a synthetic moisturizing component with the function closest to the AQUARIZER EJ and NMF components. Amino acids (glycine, DL-alanine, L-arginine, L-sodium glutamate, L-bistidine hydrochloride, sodium L-aspartate, L-valine, L-leucine) and reducing sugar (glucose, fructose) in an alcohol solution The product is condensed and sodium chloride, potassium chloride, calcium chloride, sodium lactate and urea are added to the product. It has the effect of regulating fluctuations in skin pH and moisture, and when formulated in cosmetics, it gives moisture to the skin and prevents rough skin.

It is an amino acid-based humectant in an aqueous solution of Produ, sodium DL pyrrolidone carboxylate, L-proline, sodium lactate, sorbit, and hydrolyzed collagen. As a complex of NMF components, it is particularly effective in keeping moisture and keeps the skin fresh.

It is a mixture of sugars obtained by mixing a mixed isomerized sugar (bentapaiten), a diluted alkaline processed product of glucose and a diluted alkaline processed product of lactose in a ratio of 19: 1, and mainly consists of glucose and fructose. A yellowish red transparent liquid with a slight odor. It is a mixture of sugars having almost the same composition as the neutral sugar component which is one of the skin moisturizing components (NMF). Compared to ordinary moisturizers, it has a moisturizing effect even at low humidity and is durable.

Amino acids and carboxylic acids having amino groups are collectively referred to as amino acids. Generally, it is a colorless crystal that is easily soluble in water and decomposes at 200-300 ° C. It is a component of the protein of one of the three major nutrients, and operates various metabolisms as the base of physiologically active substances such as nucleic acids and hormones. Twenty or more species are known in nature, of which eight amino acids that are not synthesized in the body and that need to be taken from food are called essential amino acids. Proteins in food are digested, broken down into amino acids, absorbed, biosynthesized again into proteins, and used in the living body. Proteins are the main constituents of skin and hair. It is also contained in sweat and has the function of adjusting the pH and moisture content of the skin. Amino acids have the effect of restoring hydration to the dry epidermis.

L-aspartic acid, many proteins, particularly present in the plant kingdom and abundant in germinated beans. Currently, it is industrially produced by an enzymatic method. It is not white crystalline powder and has almost no odor. It is a non-essential amino acid that is closely related to ammonia metabolism and the urea cycle, and has effects such as treatment of waste products in the body, promotion of liver function, and recovery from fatigue. In addition, it is effective for metabolism of the living body, has growth promotion and cell activation action, and is used for pharmaceuticals and cosmetics. It is also used as a seasoning for food.

It is obtained by neutralizing sodium L-aspartate and L-aspartate with sodium hydroxide. Other salts of aspartic acid include potassium aspartate, dipotassium aspartate, and magnesium aspartate. It has umami and salty taste and is used as a seasoning for food. In cosmetics, it is used for soaps, various creams, lotions, shampoos and rinses.

DL-alanine, the simplest amino acid with a single carbon. Colorless to white crystals or crystalline powder with no odor and sweet taste. It has an important link in carbohydrate metabolism and is involved in fatty acid biosynthesis. DL-alanine is used as a synthetic liquor, fruit juice drink, and antacid. Β-Alanine is the isomer of alanine, and is the only naturally occurring β-amino acid and a biologically important amino acid. The composition of NMF contains about 40% of 16 kinds of amino acids such as serine and alanine in free form, suggesting that amino acids are an interesting substance as a cosmetic raw material.

L-arginine is widely distributed as a component of biological proteins, but it is particularly abundant in protamine, a protein of fish larvae. It exists in a free state in plant seeds. White crystals or crystalline powder with a slightly unique odor. Although it is a non-essential amino acid, it is an essential amino acid in infants because of its slow in vivo production rate. Used as a sweat function promoter, a therapeutic agent for ammonia poisoning of liver disease, and an important component of protein source supplementation. In cosmetics, it is widely used as a neutralizing agent instead of triethanolamine.

L-isoleucine and L-isoleucine, together with L-leucine, enhance the water retention of a microemulsion that forms a structure (lamellar structure) similar to intercellular lipids. Almost all proteins are present with L-leucine. It is a component of peptide hormones and peptide antibiotics. White cord or crystalline powder with no odor and slightly bitter taste. It is an essential amino acid for growth and essential for infants. Deficiency causes skeletal muscle damage. Used as a protein synthesis material in vivo. Used as an essential amino acid fortifier in various fortified foods. It is also effective as a growth agent and anti-anemic agent, and is used as a raw material for nutrients and amino acid infusions. Also used in cosmetics.

Lysine hydrochloride (L-lysine salt salt), present as a constituent amino acid of almost all proteins. It has the same structure as natural lysine. White powder with no odor or slightly unique odor. Although it is an essential amino acid for nutrition, unlike other amino acids, once it undergoes metabolism, it will not be restored once it has been changed, so it must be replenished from outside the body. It is a kind of amino acid contained in a large amount in NMF contained in the stratum corneum, and gives skin flexibility and elasticity. It is effective for rough skin and red skin, and is used for protective creams and ointments. It also has the effect of promoting bone and tooth formation.

Glycine (aminoacetic acid), glycine, is the simplest and only amino acid with no carbon atoms. It is white crystals or crystalline powder, has no smell, and has a sweet taste. Glycine is biosynthesized from serine and the like in vivo. Furthermore, many physiologically important substances such as creatine, glutathione and glycolic acid are biosynthesized from glycine. Detoxifies and is excreted in the urine. In addition, it has a stronger vasodilatory effect than ethanol. As a pharmaceutical, it is used as a nutrient, an antacid, an antidote, and a creatine production promoter for myasthenia. As a food, it is used as a seasoning and preservation department. Cosmetic raw materials have antibacterial action, chelating action, antioxidant action, etc., and are used in soaps, toothpastes, hair products, creams, facials and the like.

L-glutamine is widely distributed in the plant kingdom as a constituent amino acid of free or protein. White crystalline powder with no smell and slightly unique taste. It is unstable in acid, alkali or hot water, and is hydrolyzed to L-pyrrolidone carboxylic acid. It is widely used as a therapeutic agent for digestive ulcers, and in cosmetics, it is used as an conditioning agent to a skin conditioning agent.

L-glutamic acid, a main constituent in natural proteins, is widely present in living tissues and foods in a free state. White crystals or crystalline powder with no odor and slightly unique taste and acidity. Glutamic acid is an amino acid that plays an important role in the in vivo metabolism of many substances. In addition, its content in the brain is remarkably high, it becomes an important energy source and is also involved in brain metabolism. Used in soaps, soaps, rinses, hair cosmetics, makeup cosmetics, and basic cosmetics. In food, it is often used as a sodium salt.

Sodium L-glutamate, a compound discovered by Kikuna Ikeda in 1908 by investigating the umami component of soup stock from kombu. Since then it has been commercialized as an artificial seasoning. The umami taste of sodium L-glutamate is said to be due to the molecular structure of glutamate ions. Industrially, it is produced by a fermentation method using bacteria having glutamic acid producing ability. It is also used in cosmetics such as soap, shampoo, rinse and basic cosmetics.

γ-aminobutyric acid (piperidine acid), potato rhizome, apple flesh, red beet root, legume root nodules, tea leaves, mammalian brain spinal cord, etc. Yes. Industrially, it can be obtained by synthesizing L-glutamic acid. γ-Aminobutyric acid has a function of enhancing the proliferation ability, repair ability, and water retention ability of skin cells. When skin cells lack energy, their ability to proliferate, repair, and retain water decreases, and healthy cells cannot be produced, resulting in aging phenomena such as reduced skin elasticity and generation of wrinkles. Mitochondria is responsible for the energy of cells, and γ-aminobutyric acid is attracting attention as a component that enhances the mitochondrial energie production. Used as a remedy for epilepsy, cerebral hemorrhage, and hypertension, but is also used in cosmetics.

L-threonine (L-threonine) is the last discovered essential amino acid. It is abundant in animal proteins such as milk, meat, and eggs as protein-constituting amino acids, and slightly less in plant proteins. It is a kind of essential amino acid and is used as a protein synthesis material in vivo. As a comprehensive amino acid preparation, hypoproteinemia, malnutrition, amino acid supplementation before and after surgery is administered intravenously, intravenously or intravenously. Applied to cosmetics as a skin moisturizer.

Sericin, a fibrous protein derived from silk, is a white solid hard protein obtained by hydrothermal treatment and ethanol purification of a brownish gray liquid. It consists of fibroin and forms a uniform protective film on the skin and hair. The double silk thread of the cocoon is covered with a sericin protective film. The amino acid chain (polypeptide) contained in this sericin is similar to the protein constituting the skin and has excellent adhesion. Moreover, since it contains a large amount of serine and aspartic acid, it has water retention. A hydrophilic amino acid group contained in a large amount in sericin has a high affinity for a large number of proteins. Has skin affinity, moisturizing effect, and cell activation effect. Used for basic cosmetics such as creams and emulsions because of its smooth feel and film properties.

Serine is contained in many proteins in small amounts, but is particularly found in sericin, a silk protein. A non-essential amino acid that is biosynthesized from glucose (dextrose) and is further degraded to produce glycine. NMF contains the largest amount as a free amino acid. Moisturizing effect is high and gives skin flexibility and elasticity.

It is an amino acid that produces L-tyrosine (L-tyrosine), adrenaline, which is an adrenal medullary hormone, and melanin, which is the black pigment of living organisms. Used as a treatment for Graves' disease (hyperthyroidism). In cosmetics, it is used as a nutrient.

L-tryptophan, a small amount of various proteins, is present. Moreover, it exists in the free state in the bud of a plant. It is an essential amino acid and is not synthesized in the body. It is an important amino acid that is indispensable for life support, such as changing to nicotinic acid, a kind of pitamine, and serotonin, a blood pressure-increasing substance. As a pharmaceutical, it is blended with other amino acids and used as a component in amino acid infusion solutions and prescription amino acid preparations. It has an antioxidant effect on fats and oils and is used as a food quality retainer and reinforcing agent. As a cosmetic, it is blended as a nutrient.

L-valine is an essential essential amino acid that is essential for nutrition and is involved in the expression of bitterness specific to sea urchin. White crystals or crystalline powder, no odor, slightly sweet taste but later bitter. Used in nutrients and food seasonings. In addition, it is used together with other essential amino acids in amino acid infusions and general amino acid preparations. In cosmetics, it is used in soaps, soaps, rinses, hair cosmetics, foundations, creams, milky lotions, lotions, packs, facials and the like.

It is obtained as a by-product in separating lysine from L-histidine hydrochloride, a defatted soybean hydrolyzate. White crystals or crystalline powder, odorless. Used in soaps, shampoos, rinses, makeup cosmetics, various creams and lotions.

L-hydroxyproline (L-oxyproline) is an amino acid that is contained in a large amount only in collagen and is not found in other general proteins. Thus, the presence of hydroxyproline is evidence of the presence of collagen. Hydroxyproline in collagen is considered to be oxidized to hydroxyproline after proline is synthesized into collagen. A non-essential amino acid, which has the same structure as proline, but is more susceptible to oxidation than proline because it has a hydroxyl group. It has skin conditioning and hair conditioning effects, and is used in creams, emulsions, lotions, packs, facial cleansers, etc.

Phenylalanine is present in about 2 to 5% in various proteins, but is often found in a free state in seed shoots. It is a white crystal or crystalline powder, smell is slightly bitter, and tastes slightly bitter. It is a kind of essential amino acid that is indispensable for nutrition and growth as the main course of protein production. In addition to being used to strengthen essential amino acids as a component of amino acid infusions and general amino acid preparations, it is also used as a moisturizer for cosmetics. Also used in food seasonings.

L-proline is contained in many proteins, but is most abundant in gelatin (about 15%). In vivo, glutamic acid is biosynthesized, but it is converted to pyrrolidone carboxylic acid by proline oxidase, and further to glutamic acid. No white crystals or crystalline powder, no odor, or a unique odor and a slightly sweet taste. It differs from others in that it is an amino acid that is easily soluble in ethanol. It has a conditioning effect and is used in basic cosmetics and hair cosmetics.

L-leucine exists as a constituent amino acid of most proteins. In addition to being used as a protein synthesis material in vivo, it undergoes a metabolic process similar to that of fatty acids and finally decomposes into acetyl coenzyme A and acetoacetate. It is a white crystal or crystalline powder, has no smell, and tastes slightly bitter. It is a kind of essential amino acid and is not synthesized in vivo. Has skin conditioning and hair conditioning effects and is used in creams, milky lotions, facial cleansers, shampoos, rinses, hair cosmetics, etc.

Pyrrolidone carboxylic acid is produced when DL-bilolidon carboxylic acid (PCA) and glutamic acid are heated to 150 ° C. or lower. Without white crystals or crystalline powder. There is no smell. Pyrrolidone carboxylic acid present in the skin is contained in the form of salt (en) and plays a role as a natural moisturizing group. When used for fermentation such as soy sauce, cosmetics widely used in products and plants such as soybeans, molasses and vegetables, pyrrolidone carboxylic acid is not hygroscopic and must be in the form of salt. Used as a triethanolamino salt, it provides warmth, softening and elasticity to skin and hair. Used as a moisturizer in soaps, creams, lotions, emulsions, hair cosmetics, facials, shampoos and rinses.

DL-pyrrolidone sodium carbonate solution (PCA soda), 50% aqueous solution of sodium pyrrolidonecarboxylate. A colorless, transparent liquid with no odor. Pyrrolidonecarboxylic acid is abundant in the skin in the form of a salt and plays an important role as NMF. It is very hygroscopic and exhibits good wettability to skin and hair, giving softener and elasticity. Stable at high and low temperatures. There is almost no irritation to skin and eyes even at high concentrations, and it is used as a moisturizer for basic cosmetics such as creams and emulsions. It is also used in soaps and shampoos.

Although known as lactic acid, an organic acid present in septic milk, it is widely present in the animal and plant kingdoms. Manufactured by a fermentation method using starch or a synthesis method in which acetaldehyde is allowed to act on acetaldehyde. A colorless to pale yellow viscous liquid with a slightly unique odor. Since the diluted solution has a bactericidal action as well as a gentle keratolytic action, it can be used for astringents, milky lotions, whitening creams, and hair-washing cosmetics. In addition to the early stage of liquor fermentation, it is also used to prevent the growth of spoilage bacteria.

Sodium lactate (liquid) is an important natural moisturizing component present in NMF, and exhibits high moisture absorption. It is a colorless and transparent viscous liquid with no odor or slightly unique odor. It is obtained by reacting lactic acid with a sodium hydroxide solution, and is widely used as a substitute for glycerin because it has glycerin-like properties. It also has the property of making the texture of O / W type cream finer.

In addition to the method of concentrating and separating from urea and urine, it can also be obtained industrially. Colorless to white crystals or crystalline powder with no odor and cool salty taste. It has mild bactericidal action and is said to increase antibacterial activity through a synergistic effect in combination with sulfamines, and its toxicity is extremely low. It has a wound healing effect and cell activation effect and is blended into hand creams and lotions. It is also used for cold wave liquid as a hair swelling agent and shampoo as a wetting agent. In addition, it is used for soap, eyeliner, foundation, sunscreen cream, shaving lotion, eye cream and the like. It is also used as an external skin preparation as a pharmaceutical urea ointment.

Uric acid, a substance produced when proteins break down in the animal's body and excreted in the urine. Colorless or white crystals, tasteless. It is used as a pH adjuster and emollient as a cosmetic raw material.

Acid mucopolysaccharide, a mucopolysaccharide that is one of the main components of the dermis, has a function of forming a complex with collagen to retain moisture in the dermis, and is thus also involved in skin aging. Acidic mucopolysaccharides extracted from bovine umbilical cords and chicken crests are used as cosmetic raw materials with the expectation of water retention effect on the skin. These acidic mucopolysaccharides are composed of hyaluronic acid and chondroitin sulfate, and dermatan sulfate and heparin are also combined. It has excellent moisturizing effect along with the excellent touch unique to polysaccharides. Hyaluronic acid, the main component of acid-injected mucopolysaccharides, is a polysaccharide composed of glucosamine (a kind of amino sugar) and glucuronic acid (a kind of uronic acid), but it retains a large amount of water around it. Theoretically, it is said that 600 ml or more of water can be held per 1 g of hyaluronic acid. Such moisture retention effect of hyaluronic acid has been in the limelight and is used in cosmetics in the form of sodium hyaluronate. Chondroitin sulfate sodium salt is a sodium salt of acidic mucopolysaccharides composed of hexosamine, uronic acid, and sulfuric acid, but is used for improving the moisturizing agent or feeling of use.

Saitai extract (saitai extract) is a pale yellow transparent and viscous liquid containing acidic mucopolysaccharide extracted from the umbilical cord of healthy cattle as a starting material. Ingredients are hyaluronic acid, chondroitin sulfate, dermatan sulfate, hebaran stone application, heparin, keratan sulfate. Excellent moisture retention and viscosity unique to polysaccharides. As a heat-retaining agent, it is used in basic cosmetics such as creams, lotions, and emulsions.

Tosaka extract (hydrolyzed Tosaka solution, Fipra N), a solution of acidic mucopolysaccharides rich in hyaluronic acid obtained by hydrolyzing chicken Tosaka with a proteolytic enzyme. A clear, colorless or slightly yellowish viscous liquid with a distinctive odor. It forms a film on the skin surface with high viscosity and high water retention, gives an excellent feeling of use, and is less susceptible to external humidity and moisturizes the skin compared to other moisturizing agents. It has high water retention and is widely used in various cosmetics as an excellent moisturizing agent.

Hyaluronic acid and hyaluronic acid are typical acidic mucopolysaccharides separated and named from the glass body of bovine eyes by Meyer et al. In 1934, and are distributed in connective tissues of mammals together with chondroitin sulfate. Functions within the connective tissue are to retain water in the interstitial space, and to form cells in the tissue to form a jelly-like matrix (lattice shape), to keep the skin moist and flexible, and to apply external force , And prevent bacterial infections. Hyaluronic acid is present in the epidermis and dermis more than chondroitin sulfate and heparin, and the moisture retention of this hyaluronic acid contributes to the freshness of the skin. The reason why the skin is not fresh and wrinkled is said to be because hyaluronic acid containing abundant water from the connective tissue of the dermis is reduced. Although it is a substance that plays a major role in water retention capacity in this way, hyaluronic acid is present only in trace amounts in the body, and because it forms a complex with proteins and other mucopolysaccharides, In manufacturing from chicken chicken etc., it has complicated processes such as separation and purification. For this reason, hyaluronic acid has become a very expensive raw material, and there have been practical restrictions. Therefore, a method for producing inexpensive and pure biohyaluronic acid obtained by fermentation using microorganisms was established and put into practical use. Biohyaluronic acid is chemically identical to natural hyaluronic acid. Due to these circumstances, many cosmetics containing hyaluronic acid have appeared today. Hyaluronic acid is well absorbed by the skin and does not stick well and has the effect of increasing the moisture content of the stratum corneum. In addition, it is greatly different from other moisturizing agents in that it has the property of keeping its moisturizing property constant regardless of the humidity in the air. Furthermore, the synergistic effect (moisturizing effect and skin improvement effect) of the combined use of polyalcohol such as hyaluronic acid and glycerin can be enhanced. Cosmetics are formulated in the form of sodium hyaluronate.

Some are derived from animals obtained from sodium hyaluronate, chicken Tosaka, etc., and some are obtained by fermentation using microorganisms. Natural sodium hyaluronate is a white to pale yellow powder with a slight odor. Sodium biohyaluronate is a white to pale yellow powder with a slight odor. The sodium hyaluronate solution is a colorless viscous liquid with a slight odor. It has excellent water retention and permeability, and gives skin firmness and smoothness. Widely used as a moisturizer such as cream, milky lotion, beauty essence, cosmetics for hair, lipstick, lip balm, shampoo, rinse, eye shadow, eyeliner, mascara, blusher, funny and foundation.

Chondroitin sulfate sodium salt is a sodium salt of chondroitin sulfate obtained by extraction and purification from mammalian or fish cartilage. A kind of acidic mucopolysaccharide that binds to proteins and is widely distributed in animals as a matrix component of cartilage, bone, health, blood vessel wall, skin and other connective tissues. White to pale yellowish white powder with slightly unique smell and taste. It is hygroscopic and well soluble in water, but is hardly soluble in alcohol, acetone, etc. It is used for creams, foundations, lipsticks, toothpastes, etc. as a moisturizing agent or a touch-improving agent that gives a smooth feeling of use because of its properties as a water-soluble polymer (dissolves in water to produce a highly viscous mucus). For medicinal purposes, it is used for the treatment and prevention of arteriosclerosis, detoxification, neuralgia, arthritis, or nephritis, and is also included in eye drops. It is also used as a food-related humectant and emulsion stabilizer.

Glucuronic acid, a typical uronic acid, is distributed in the animal kingdom as components such as chondroitin sulfate and hyaluronic acid. It exists in urine in the form of glycosides with alcohols and phenols, and in the liver, it functions to detoxify toxic substances having hydroxyl groups. It can be obtained by a general process for producing uronic acid.

Collagen and collagen are fibrous proteins that constitute collagen fibers of connective tissues such as mammalian skin, tendons, bones, and blood vessels. The structure consists of about 20 amino acids such as glycine, proline, alanine, hydroxyproline, glutamic acid, and arginine. Collagen includes soluble (insoluble) collagen and insoluble (insoluble) collagen. Soluble collagen is collagen that does not cause cross-linking (intermolecular cross-linking) in which the molecules can be freely replaced in the body tissue, and the skin. Gives water retention and elasticity. In addition, skin that has been aged or exposed to extraneous lines has increased collagen cross-linking and increased insoluble collagen, resulting in decreased elasticity and water retention capacity, formation of wrinkles, and aging of the skin. Soluble collagen stimulates fiber-forming cells in the connective tissue of the skin, promotes fresh fiber formation, enhances capillary function, increases water retention capacity and elasticity, so it can be used in cosmetics to prevent skin aging and rejuvenate. in use.

Extracted from soluble collagen (water-soluble collagen), bovine or porcine skin, bone marrow tissue or bovine placenta. Collagen molecules consist of three polypeptide chains with a molecular weight of 100,000 (consisting of about 1000 amino acids), and the three chains are braided in a spiral shape. Both ends of this molecule are not wrapped in a spiral and are called telopeptides. This part is cross-linked (bridged) and is related to antigenicity. When a young tissue such as calf skin is extracted with a dilute acid aqueous solution, collagen molecules that are not linked by intermolecular crosslinking (no cross-linking) are obtained. Thus, what is extracted by molecular dispersion is soluble collagen. The amount of soluble collagen obtained by extraction is very small, about several percent, and cannot be obtained in large quantities. Soluble collagen is a colorless or milky white liquid or paste, or a white to pale yellow powder with a unique odor. When the aqueous solution is heated to 40 ° C. or higher, the helix is unwound to become gelatin and the viscosity is lost. 1% of the amino acids contained in collagen is glycine, which is combined with hydroxyproline, which is not found in other proteins. When formulated in cosmetics, it has excellent compatibility with the skin and can be expected to have a protective effect on the skin. Because it hydrates well with water, it contributes to the improvement of the moisture retention function by hydrating the skin and does not interfere with the normal physiological function of the skin.

Collagen hydrolyzate (hydrolyzed collagen), a collagen protein hydrolyzate obtained by hydrolyzing mainly bone or skin of cow or pig with acid, alkali, enzyme or the like. Prevents hair damage, gives hair softness and gloss, and improves anti-combination due to its antistatic effect. For skin, keep moisture in dry skin to prevent rough skin and maintain moisture and suppleness.

It is an aqueous solution of a hydrolyzed collagen solution, a collagen protein hydrolyzate, or a salt thereof. Light yellow to dark brown clear or slightly turbid liquid with a specific odor. Protective, moisturizing and softening effects on skin and hair.

Hydrolyzed collagen powder and collagen protein hydrolyzate are powdered. White to light yellow powder with no odor or slightly specific odor. It dissolves in water and becomes a nearly transparent or slightly turbid viscous liquid that does not gel at room temperature. It has protective action, wetting action, and softening action and is widely used in cosmetics.

It is a 25% ethanol solution of hydrolyzed collagen ethyl and ethyl ester of collagen protein hydrolyzate. A pale yellow to brown transparent or turbid liquid with a specific odor. As a conditioning agent, it is used in shampoos, rinses, creams, milky lotions, makeup cosmetics and the like.

This is an ethanol solution of hydrolyzed collagen hexadecyl, an ester of a hydrolyzate of collagen protein and hexadecyl alcohol. It is a pale yellow transparent liquid with a smell. Protective, moisturizing and softening action on skin and hair. Gives an oily gloss.

It is a mixture of amino acids obtained by completely hydrolyzing collagen amino acids and collagen proteins. Including glycine, proline, hydroxyproline, glutamic acid, alanine, arginine, aspartic acid, leucine and isoleucine, lysine, valine, serine and the like. It has a conditioning effect on skin and hair, and is used in cosmetics for hair, creams, lotions and the like.

Atelocollagen and insoluble collagen are treated with protease (proteolytic enzyme) to remove the antigenic telopeptides at both ends of the collagen molecule, and the purified collagen is called atelocollagen. Originally, telopeptides are different from the collagen molecule body, and the amino acid composition is different from the body, and is likely to cause allergic reactions. Therefore, it can be said that atelocollagen from which telopeptides have been cleaved is less likely to cause an allergic reaction. Atelocollagen has been applied as a medical material such as a skin covering material for burns and skin defects, but since it is expected to have a moisturizing effect on the skin like soluble collagen, it is used in cosmetics.

It exhibits a jelly-like shape obtained by heating and scouring crude collagen obtained by treating gelatin, animal bones, skin, ligaments or tendons with acid or alkali. Colorless to pale yellow bookboard, strips, grains or powder with no odor and taste. Although it does not dissolve in water, when water is added, it gradually swells and absorbs 5 to 10 times the amount of water. Collagen contained in animal connective tissue is an anhydrous form of gelatin. Used in cosmetics as an emulsifier emulsion stabilizer, thickener, jelly base and the like. Moreover, it is used also as solid binder etc. as a binder. As pharmaceutical formulation bases, they are also used in capsules, tablets, troches, suppositories, and also in bacterial test media. In addition, it is widely used in confectionery, food crystal processing, photographic emulsion, black ink, adhesives, etc.

Hydrolyzed gelatin powder, a water-soluble powder protein obtained by hydrolyzing gelatin. The amino acid composition of gelatin is often combined with glycine, proline, oxyproline and the like. It has excellent effects such as protective colloid, emulsification and adhesion.

It is the same fibrous protein as elastin and collagen, and is a component of elastic fibers in connective tissues such as the dermis. It has elasticity like rubber, and unlike collagen, it does not change even with hot water treatment and does not become glue. It is also more resistant to collagen than acid, alkali and enzyme action. Elastin exhibits rubber-like elasticity because the elastin polypeptide chain is appropriately bound at the crosslinking point. When the skin deforms, the collagen network deforms and the elastin tangled with the collagen becomes tense. When the force is removed, the skin returns to its original state due to the contraction force of elastin. Thus, elastin plays an important role in preventing skin sagging and wrinkles. When the skin ages, the elastin content decreases, the elasticity is lost, and wrinkles are thought to occur.

Water-soluble elastin and elastin are present in connective tissue together with collagen and are involved in the stretchability of the tissue. The skin dermis contains 1.5 to 4.8% by dry weight. Elastin is usually insoluble and must be chemically treated to make it water soluble. Water-soluble elastin is water-soluble elastin extracted from tendon on the neck of cattle. It is a light tan liquid and odorless. The amino acid that constitutes elastin is most often glycine, and is also composed of alanine, valine, proline, and the like. Elastin blended in cosmetics is characterized by a high effect as a moisturizing component, like collagen. Gives moisture and shine to prevent dryness and smoothes skin that tends to sag. Used in creams, emulsions, lotions, packs, facials, foundations, etc.

Hydrolyzed elastin (elastin hydrolyzate), usually elastin is insoluble, so that hydrolyzed elastin is hydrolyzed by chemical treatment with acid or alkali or elastase to make it soluble. The aqueous solution is a light tan to brownish brown liquid with no odor or slightly unique odor. Elastin contains a fluorescent substance, and hydrolyzed elastin is often colored yellow. It is effective in improving the protection of skin and hair and increasing the flexibility of the epidermis. It is also useful for improving the feel of cosmetics.

Intercellular lipids and sebum prevent moisture from evaporating outside the skin, whereas substances that act to retain moisture inside the skin are substances called intercellular lipids. These lipids are composed of ceramide, free fatty acid, cholesterol, cholesterol sulfate and the like. The intercellular lipid fills the space between cells in the stratum corneum of the epidermis and plays a role in arranging a clean layer by connecting cells. If this is compared to a building, keratinocytes are blocks, and intercellular lipids are cement that serves to bond the blocks to each other. Intercellular lipids have a special layered structure (lipid bilayer), and the moisture retention function is achieved by inserting moisture into the intercellular lipid. In senile xeroderma that appears in the skin of the elderly, keratinization does not occur normally due to aging, and intercellular lipids are not formed normally, so that the horny layer transpiration increases and the skin becomes abnormally dry. Since intercellular lipids decrease with aging, they are also an indicator of skin youth.

Sphingolipid (ceramide), a kind of keratinocyte lipid, is an active ingredient that protects moisture and adjusts texture. Intercellular lipids have been found to fill epidermal cells and prevent moisture transpiration. Ceramide plays an important role in water retention in the keratin, and sphingolipids mainly composed of ceramide are extracted from the brain of mammals. It is blended as an agent. Similar intercellular lipids include extracted and purified soybean lecithin and aged chamomile.

Pale yellow obtained by further refinement of HS oil (HS lipid), fatty acids obtained by hydrolyzing terrestrial animal oil and marine animal oil, fractionating and purifying, adding and adding the fatty acid to this, and re-synthesized It is an ointment solid. It has a fatty acid composition similar to that of human sebum and is a stable fat and oil with little odor and change over time. It has excellent permeability to the skin and does not give a product oil feeling even if contained in a large amount. Widely used as oily raw material for various creams, lotions, ointments, etc.

A type of structural protein that forms the tissue that covers the outermost layer of the animal body, such as hair, nails, feathers, and horns, with the same fibrous protein as keratin and collagen. It plays a role in protecting the inside of a living body from chemical and physical stimuli outside the body. The keratin of the skin is also made of keratin and retains moisture in the stratum corneum. Unlike collagen and elastin, there are many cystine in the constituent amino acids, and many amino acid chains are tightly linked by cystine bond (SS bond), which is a tough, insoluble, physically and mechanically resistant cell. , Play the role of armor. However, it is weak against reducing agents such as thioglycolic acid, oxidizing agents such as hydrogen peroxide, and substances that cleave cystine bonds such as alkalis. Permanent wave agents and hair removal agents are made using this property. .

Hydrolyzed keratin and keratin are proteins contained in the stratum corneum of the epidermis, hair and nails, and contain a large amount of cystine, which is a sulfur-containing amino acid (amino acid containing sulfur atoms). Hydrolyzed keratin applied to cosmetics is obtained by further hydrolyzing a cistin bond (S-S bond) with acid, alkali, enzyme, etc. to make the molecular weight about several thousand. There are aqueous solutions and powdered ones. A pale yellow to brown powder with a slightly unique odor. The aqueous solution is a light yellow to brown transparent liquid. It contains many polar amino acids, with many of the constituent amino acids such as glutamic acid and cystine. As a skin and hair conditioning agent, it is used in creams, emulsions, shampoos, rinses, hair cosmetics and the like.

It is a mixture of keratin amino acids and amino acids obtained by completely hydrolyzing keratin. Contains a lot of glutamic acid, cystine, serine, arginine, leucine and isoleucine, proline and the like. It has skin and hair conditioning and action, and is used in cosmetics for hair, creams, emulsions, nail enamels and the like.

It is a kind of amino acid (containing amino acid) containing cystine and sulfur, and is contained in many proteins in small amounts. In particular, it is contained in a large amount in protein keratin constituting hair, skin and the like. It has a disulfide structure (-SS-) called a cystine bond in the molecule and plays an important role in hair hardness, toughness, elasticity, and extensibility. Cystine is a non-essential amino acid that is easily reduced to water-soluble cysteine, and returns to the original sparingly soluble cystine by air oxidation. In addition to being used as a hair nourishing agent, it is used to treat skin allergic diseases, antidote, hematopoietic, and psoriasis. Used in soaps, shyampoos, rinses, hair cosmetics, creams, milky lotions, lotions and packs.

L-methionine, a kind of sulfur-containing amino acid, is present in 2 to 4% in almost all proteins. As an essential amino acid, it promotes the growth of living organisms (especially hair, nails, etc.) and changes to cystine in vivo to show detoxification. It also prevents the deposition of fat in the liver in vivo. As a pharmaceutical, it is used as a comprehensive amino acid preparation for the purpose of supplementing amino acids and improving nutritional value. Cosmetics are used in shampoos, rinses, hair cosmetics, creams, emulsions, lotions, packs and the like.

Cysteine, a sulfur-containing amino acid, is a substance in which cystine is reduced and the cystine bond is broken, and is one of the substances that play an important role in metabolism in the body. The first agent of permanent wave agent (reducing agent) as well as thioglycolic acid, applying the property of reducing and releasing other substances by reducing hydrogen and oxidizing itself to cystine. It is used as the main component.

Nucleic acids are all contained in the cells that make up living organisms, and play an important role in living organisms. Depending on the type of sugar that makes them up, ribonucleic acid (RNA) and deoxyribobodies There are two types: nucleic acid (DNA). Nucleic acids are thought to play a strong role in protein synthesis in cells. There are various types of RNA, all of which are related to intracellular protein synthesis. There are three types of cells in the cell: messenger RNA that conveys information on DNA in the nucleus to the liposome, which is the place of synthesis, transfer RNA that transports amino acids, and liposome RNA that is a component of the liposome. DNA is the body of a gene that is contained in chromosomes in the nucleus, and in which molecular information is engraved in its molecular structure. With the rapid development of gene engineering and biochemical methods since the latter half of the 1970s, synthesis, replication, recombination, etc. have been attempted.

Extracted from deoxylipoic acid (DNA), calf thymus, or fish testis. This potassium salt is potassium deoxyribonucleic acid, and the sodium salt is sodium deoxyribonucleic acid. Deoxyribonucleic acid is a white or white powder and is odorless. Sodium deoxyribonucleic acid is a white or white powder. Deoxyribonucleic acid potassium is a white or white powder and has almost no odor. It is composed of nitrogen-containing base, pentose sugar and phosphoric acid. In cosmetics, DNA and its sodium salt and potassium salt are widely used because of their moisturizing effect, sebum secretion control, and cell activation.

Liponucleic acid (RNA)
It is obtained mainly by brewing and purifying from peel yeast cells. It is a white or white powder and has a slightly specific odor. Ribonucleic acid is converted into adenine, guanine, cytosine, uracil, ribose, and phosphate by complete hydrolysis. Used in soaps, shyampoos, rinses, creams, and emulsions. Obtained by extraction and purification from liponucleic acid sodium salt yeast cells. White to off-white crystalline powder, odorless. Widely used in soap, shampoo, rinse, eye shadow, blusher, foundation, cream, etc.

It is obtained by hydrolysis of guanosine and ribonucleic acid. It exists as a component of nucleic acids and is widely distributed in the living world. It is easily hydrolyzed with acid to yield guanine and D-ribose. In addition to being used as a skin conditioning agent in night creams and lotions, it is a synthetic raw material for seasonings.

It is a crystal of guanine, a constituent component of nucleic acid, and is one of important things along with adenine and hypoxanthine. Along with adenine, it is widely distributed in biological cells as a component of nucleic acid. A white to slightly yellow crystalline powder produced by chemical decomposition of guanosine with a slight odor. It is used in creams as a cell activator because it enhances the ability of skin cells to take in nutrients and helps the cells to be reborn. The aqueous solution absorbs ultraviolet rays.

Phosphoric acid is a colorless and transparent viscous liquid, but commercially available phosphoric acid is an aqueous solution of about 85%. Phosphoric acid does not exist in free form in nature, but exists in animals and plants in the form of salt. In the living body, it is an essential component for the maintenance growth and metabolism of the living body as a component of nucleic acid, and it has been clarified biochemically that it is an extremely important component. In cosmetics, it is blended as an antioxidant auxiliary agent for the purpose of synergistic effects of antioxidants, and is used as a pH adjuster for lotions and creams. Moreover, it may mix | blend with a mouthwash as a detergent.

ATP (adenosine triphosphate, adenosine triphosphate), an extremely important substance that serves as an energy source for living organisms, is called the living energy currency. It is a phosphate-bound adenosine and is widely found in various animal and plant cells, from bacteria and amoeba to humans. It is used in creams, milky lotions and the like as a cell activator that makes skin cells alive.

It is obtained by neutralizing riboflavin sodium phosphate or riboflavin phosphate obtained by phosphorylation of riboflavin with sodium carbonate or sodium hydroxide. It is a yellow to orange-yellow crystalline powder with no odor and a slightly bitter taste. Extremely hygroscopic and decomposes by light. In food, it is used as a fortifier in the same way as riboflavin. In cosmetics, it is used in creams, milky lotions, skin lotions, facials and the like.

A generic term for phospholipids and lipids bound to phosphoric acid. Some of them are widely distributed in the living body and play an important role in metabolic processes. Typical examples are lecithin and kephalin, which are abundant in egg yolk, soybean, germ and the like. In cosmetics, it is blended as an emulsifier, emollient and moisturizer. The lipid contained in the skin contains a considerable amount of phospholipid, and when it is removed by washing or the like, it can be compensated by using a cream containing phospholipid.

It is contained in lecithin, egg yolk, soybeans, etc., and these can be obtained as raw materials. It belongs to phospholipids and is a substance consisting of fatty acids, glycerin, phosphoric acid and choline. When absorbed from the skin, it produces choline or acetylcholine, which has a vasodilatory effect and promotes hair growth. Dermatology uses lecithin ointment for hair growth and frostbite. Lecithin has both lipophilic and hydrophilic properties and is applied to emulsifiers and liposomal agents.

Soybean phospholipid (soybean lecithin), a phospholipid extracted from soybeans. A pale yellow to brown transparent or translucent highly viscous substance with a slightly unique odor. As a natural surfactant, it is used for many purposes in many fields. Used as an emulsifier, moisturizer, liposomal agent in creams, emulsions, foundations, lotions and the like. In many cases, hydrogenated soybean lecithin that has been oxidized and stabilized by hydrogenation is used. In the pharmaceutical field, it is also used for the purpose of lowering anti-arteriosclerotic cholesterol and lowering blood pressure. Also in the food field, it is used as an emulsifying dispersant such as bread, a quality improving agent for noodles, and an emulsifying stabilizer such as margarine.

Soybean lysophospholipid (lysolecithin) and lecithin are obtained by removing one alkyl chain with an enzyme. More hydrophilic than lecithin and stronger surface activity. It is a kind of complex lipid. Like the liposome, it is very similar to the composition of the cell membrane, so it penetrates into the cells inside the skin and enters the cell membrane to enhance the moisturizing effect. It has been noted that lysophospholipid has a hyaluronic acid production promoting action by lysophospholipid.

Egg yolk lecithin (egg yolk phospholipid), light yellow to orange yellow sticky substance or powder obtained from chicken egg yolk. Contains 60% or more of phospholipids. There is also hydrogenated egg yolk lecithin that has been hydrogenated to egg yolk oil obtained from egg yolk and further refined to improve stability. It is a lecithin that is easy to use as a natural surfactant. In addition, it has a high moisturizing effect and extremely good adhesion to the skin. It is used as an emulsifier, moisturizer, emollient, and liposomal agent in creams, emulsions, foundations, lotions and the like.

Enzyme is a generic name for proteins that are made in living cells and act as catalysts. Innumerable complex chemical reactions such as decomposition, synthesis, oxidation, and reduction in vivo are easily and smoothly performed under mild conditions by the action of enzymes. In most cases, enzyme catalysis is very specific, acting only on two substances or a group of substances with common structural elements. There are many types of enzymes in the living body, but they are usually divided into six types such as oxidoreductase, hydrolase, transferase, detachment enzyme, isomerase, and synthase depending on their functions. Well known are digestive enzymes that hydrolyze food, and proteolytic enzymes (proteases) and lipolytic enzymes (lipases) are applied in cosmetics. Fermentation and rot are also reactions performed by enzymes produced by microorganisms. Since the enzyme is a protein, its action is quickly lost due to various external conditions, that is, the presence of water, temperature, pH, presence of metal ions, etc., and therefore strict attention is required for storage and storage.

Plant complex enzymes and plant complex enzymes are extracted from a group of over 60 types of plants such as vegetables, fruits, wild grasses, and seaweeds. The enzyme's unique functions include proteolytic action, lipolytic action, anti-inflammatory action, and permeation. There are other functions. Originally widely used for medical purposes, it has come to be used in the cosmetics field. Although the amount used in cosmetics is a small amount, the gentle action of the plant smoothly removes aging keratin, promotes sweat secretion from the sweat glands and sebum from the sebum line, and facilitates skin respiration. There is such a work.

A general term for proteolytic enzymes and enzymes that hydrolyze proteins, also called protease. It breaks down the peptide bond in the protein and breaks it down sequentially into proteose, peptone, and amino acid. It exists widely in living tissues and cells and plays an important role as a digestive enzyme. Digestive fluids include pepsin in gastric juice, trypsin in pancreatic juice, and engineered repsin in intestinal fluid. In cosmetics, it is blended in soaps, facials, bath preparations, etc. as an enzyme cleanser for the purpose of degrading aging skin and making it smooth skin.

It is a highly effective enzyme that decomposes and removes lipolytic enzymes (lipases) and unnecessary sebum on the skin surface that makes it difficult to remove dirt. Used in facial cleansing products.

About animal and vegetable ingredients.

Aseptically extracted with purified water from placenta extract of placenta extract (placenta representation), cow, pig and sheep. Various types of pitamines (thiamine, riboflavin, pyridoxine, pantothenic acid, other amino acids (arginine, cystine, glutamic acid, serine, etc.), minerals (calcium, sodium, potassium, etc.), and cholesterol, cholesterol esters , Enzyme (alkaline phosphatase), deoxyribonucleic acid, these components enhance skin tissue respiration, inhibit melanogenesis, soften skin, improve freckles, and improve peripheral blood flow disorders. A wide range of therapeutic effects are recognized, such as improvement, fine wrinkles, rough skin, etc. In cosmetics, in addition to moisturizing the skin, it has multiple purposes such as preventing pigmentation, preventing wrinkles, and preventing hair loss. in use.

Animal placenta extract, a tissue extract extracted from a healthy cow or pig animal placenta during the pregnancy service period at low temperature without heat treatment or chemical treatment. It is an extract containing no hormones from which oil-soluble components have been removed. It is a colorless to pale yellow liquid with a slightly unique odor. The components are about 10 water-soluble pitamines, about 17 amino acids, about 10 minerals, and 4 other components. It is recognized to promote the respiratory action of cells and is effective in the metabolism and regeneration of skin tissue. In addition, a whitening effect is recognized. Therefore, it is effective for rough skin, sunburn spots, buckwheat, and the like, and is widely used in cosmetics and quasi drugs.

It was obtained by removing protein from bovine blood (Cernew) and an aqueous solution of bovine blood. In addition to enhancing the ability of cells to take in oxygen, it helps cells to be reborn as a cell activation component.

It is a glycoprotein with a large number of oligosaccharide chains attached to the protein skeleton. In the living body, it is said that it wraps food and its digestion residues and acts as a lubricant when moving in the digestive tract, and also protects the mucous membrane from mechanical damage. It has a hygroscopic property that is intermediate between hyaluronic acid and collagen and is less susceptible to environmental humidity. Moreover, the adsorptivity to keratin is high compared with hyaluronic acid and collagen. It is applied to cosmetics as a moisturizer.

Cattle spleen extract (revitalin), a low-molecular water-soluble extract extracted from cattle spleen. The spleen is rich in blood vessels and limba tissue, and is the most important organ constituting the reticuloendothelial system. It is also known that the spleen of mammals has an agent (splenin) involved in capillary permeability and inflammation. Like the placenta extract, revitalin has a cell activation effect that enhances the function of cells to take up oxygen and assists the reincarnation of cells. It is a cell that makes collagen and elastin that keeps the skin firm and exists in the dermis. Fibroblast growth promoting effects have also been observed. Revitalin is mainly composed of amino acids, peptides, etc., and is blended in cosmetics as a high moisturizing effect.

A bovine thymus depiction, a clear yellow-brown to brown aqueous solution extracted from bovine thymus. It has the function of activating skin cells and is incorporated into basic cosmetics and hair products for the purpose of preventing aging such as creams, emulsions and lotions.

Albumin (dried desugared egg white) and albumin are generic names for a group of soluble proteins contained in animal and plant cells and body fluids. It is obtained by spray-drying a chicken egg white that has been desugared. White to lightly responsible powder with unique smell. Constituent amino acids include glutamic acid, aspartic acid, isoleucine, leucine and the like. It has film-forming action and skin-conditioning action, and is used in creams and emulsions.

Hydrolyzed eggshell membranes (eggshell membrane keratin powder, EM protein), a thin film present on the inner surface of avian eggshell that is obtained by hydrolyzing chicken eggshell membrane with alkali or enzyme, and has a wound healing effect, It is widely known among sumo wrestlers and is still used today. The main component is protein, and sugar is bound to it, and it exists as glycoprotein. Has moisturizing effect, active oxygen removal effect, cell activation effect. It works to increase collagen in the dermis and is applied to cosmetics to prevent wrinkles.

Serum albumin accounts for 55-60% of the serum protein obtained from plasma. Cosmetics have a film-forming action and a skin-conditioning action, and are used for basic cosmetics.

Non-fat dry milk, dried from animal milk, with fat removed, mainly milk. Yellowish white powder with slightly relaxed smell and taste. It is mainly composed of protein and lactose, and also contains ash and slightly fat. It has a moisturizing effect and skin protecting effect, and is used in facials, creams, emulsions, packs, bath preparations, soaps, shampoos and rinses.

Whey (whey, lactic acid bacteria fermentation liquid), whole milk or still skimmed milk, and a transparent liquid from which a coagulum formed by fermenting an aqueous solution of glucose with lactic acid bacteria is called whey. The main component of whey is lactose, but it also contains protein and minerals. It has excellent moisturizing and absorbing properties, and has skin softening and damaged skin repairing properties. It is used as a skin conditioner in basic cosmetics.

Lactose is one of two types of milk found in the milk of nursing workers. The production method is industrially obtained as a by-product of production of butter, cheese, casein and the like. It is white, odorless crystals or powder, has no smell, and has a slightly sweet taste. Lactose is less sweet than other sugars and is about 1/6 that of sucrose. It is broken down into glucose and galactose by the enzyme lactase in the mucosal cells of the small intestine.

It is a complex protein contained in casein, milk and beans. Milk contains about 3% and is a major component of protein. Usually, calcium and double compounds bonded to carboxyl groups and phosphate groups are made and dispersed in colloidal form. The main amino acid composition is glutamic acid, lysine, aspartic acid, tyrosine, leucine and the like. It is used as a food thickener, stabilizer, emulsifier, etc. by utilizing its nutritional value, emulsifying capacity, and water retention as an excellent protein source. In cosmetics, it is used for the purpose of thickeners, suspending agents, softening agents, emulsifying aids and the like. Industrially, it is mainly used as a paper coating agent in the paper industry.

It is a powder of milk sugar protein and yellow protein obtained by hydrolyzing casein obtained from milk. A white to milky white powder with a slightly specific odor. It has a melanin production inhibitory action and a collagen synthesis promoting action, and is used for packs, super pigments and the like.

Lactoferrin (lactokine), a physiologically active substance combined with milk. It is a light yellowish red transparent liquid with little smell. Mammal milk is rich in nutrients such as proteins, lipids, carbohydrates, pitamines, and minerals, as well as other components that have physiological functions related to the adjustment of the life of young animals. This lactoferrin is an iron-binding glycoprotein contained in breast milk. It has a high antioxidant capacity and works to enhance the skin's natural defenses. It has the same antioxidant ability as SOD (active oxygen scavenger). Lactocaine is a complex of lactoferrin, pitamines, and plant extracts. It has excellent action to stop the progress of oxidation, which is the cause of aging, to enhance the protective function of the skin, to suppress inflammation caused by oxidation, and to have affinity and moisturizing protection effects.

It is a water or ethanol solution of a soluble protein obtained by hydrolyzing hydrolyzed silk and protein fibroin constituting silkworm silk fiber under acid, alkali or proteolytic enzyme. It is a white to yellowish brown liquid with a slightly unique smell. It contains a large amount of glycine, alanine, and serine, and is slightly different in terms of preventing hydrolysis such as collagen and keratin. Although it is less hygroscopic than many protein hydrolysates, it can be expected to have a good moisturizing effect because of its excellent adsorptivity to skin and hair and penetration. It also has a tyrosinase activity-inhibiting action and a whitening odor that suppresses the formation of melanin pigments. Used in soaps, shampoos, rinses, cosmetics for hair, foundations, creams, milky lotions, lotions, packs, face wash, etc.

It is a mixture of amino acids obtained by hydrolyzing silk amino acids and fibroin, which is a protein constituting silk fibers of silkworms. The main components are glycine, alanine, serine, tyrosine, valine, leucine and isoleucine. It has excellent adsorptivity and permeability to skin and hair, and forms a uniform protective film. Used in cosmetics as a conditioner for skin and hand hair.

Silk fiber obtained from silk extract and silkworm is chemically treated to obtain filtrate. It is a solution obtained by adjusting the pH of this filtrate and filtering. Slightly yellow liquid with a slightly unique smell. The main components are glycine and alanine, which have excellent adsorptivity and permeability to the skin and hand hair, and are used for basic cosmetics, hair cosmetics, and the like.

It is a powder of fibroin, a protein that forms silk powder and silk fibers of silkworms. White or off-white powder with slightly unique odor. Has high affinity for skin and hair. The smooth touch, color tone, and luster of silk improve the feeling of use and improve the flexibility and moisture retention on the skin. Soap, shiampu, rinse, hair cosmetics, makeup. Used in cosmetics, creams, emulsions, packs, and super pigments.

After condensing hydrolyzed conchiolin solution (pearl protein drawing solution), pearl oyster shells or pearls into fine powder and decalcifying them, protein conchiolin is obtained. It is an aqueous solution of a conchiolin protein hydrolyzate obtained by hydrolyzing this conchiolin. Light brown to pale yellow liquid with amino acid odor. Excellent affinity for skin and hair, giving skin and hair a refreshing and refreshing feel.

Conchiolin powder and conchiolin are hard proteins peculiar to shellfish, and are contained in shells by about 3%. In addition, pearls contain similar proteins and are thought to be involved in the growth and gloss of shells and pearls as well as their defenses. It is a type of structural protein that exists in several layers of shell membranes in shells. There are many glycine, alanine, etc., and it is similar to collagen and silk. Excellent affinity for skin and hair, giving skin a gentle and refreshing feel.

Chitin, chitosan, and chitin are a kind of polysaccharide and have a structure similar to cellulose. Chitin is distributed in nature as crab, shrimp crustaceans, insect exoskeletons, and cell wall constituents of fungi. Industrially, chitin is obtained using crab and shrimp shells as the main course. Chitosan is contained in the cell walls of certain molds in nature and is industrially produced from chitin. Chitin and chitosan have a moisturizing effect similar to that of hyaluronic acid. When blended into cosmetics, chitin and chitosan adsorb to the skin and hair to form a moisturizing effect and form a film.

Glucosamine (chitosamine), a typical natural amino sugar, is a constituent of animal and plant, microbial polysaccharides, especially mucopolysaccharides, glycoproteins and glycolipids. It is abundantly contained in shrimp and crab shells as a structural unit of chitin, and is widely distributed in animal bodies as a constituent of hyaluronic acid. It is a white crystalline powder obtained by hydrolyzing chitin with hydrochloric acid to give a hydrochloride, and is odorless. Used in cosmetics as a moisturizer.

Royal jelly (a royal milk), a viscous substance secreted by a young bee worker, is called king milk in the Japanese name. It is very nutritious and is a food given to the queen bee hatching from larvae to adults. The queen bee grows faster, grows larger and has a longer life than other bees. The amazing laying ability of this queen bee and the life span of about four times that of a worker bee are thought to be due to the consumption of royal jelly, and in Europe and the United States, royal jelly has been respected as a longevity medicine since ancient times. In addition, it is a substance that can be absorbed from the body surface of the larvae of the queen bees, and is therefore attracting attention as a cosmetic cosmetics. The components of royal jelly are composed of proteins, carbohydrates, fats, enzymes, minerals, pitamines (particularly high in pantothenic acid), and the like. Royal jelly activates cells, promotes metabolism of skin tissues, prevents spots and wrinkles, and further enhances the moisture retention of the skin. Further, hydroxydecenoic acid contained only in royal jelly has an excellent antibacterial action.

It is a collection of honey-like, yellowish-brown syrup-like viscous liquid nectar collected by honey and bees in their nests. Rapeseed, lotus, pear, acacia, mandarin orange, clover, etc. are known as plants that become the source of nectar, and there are differences in smell and color depending on the type of plant. Generally, the lighter the color, the lighter the aroma and taste. Also, flowers with flower names are not blended with domestic or imported products. 80% is sugar, mainly fructose and glucose, and contains a small amount of sucrose and maltose. In addition, it contains 10 to 20% of water, and further contains trace amounts of formic acid, lactic acid, malic acid, gum, waxy, acetylcholine, and pitamine B group. In addition to being used as a nutrient and sweetener, it is also used to prevent food from drying out. Since cosmetics have the property of smoothing the skin, they are used in massage creams, soaps, etc., and are also used as thickeners such as emulsions, loin, and water.

It is made from glucose (glucose) and starch. The taste is sweet with white crystals or crystalline powder. The most important sugar, including the polysaccharides and glycosides, is the most abundant in nature. In the plant kingdom, it is abundant in ripe fruits and is the main component of honey. In the animal kingdom, it is found in blood and lymph and found in the urine of diabetics. In addition to being used as a nutritional supplement, it is used as a sweetener in foods. In cosmetics, it is used as a daily wetting agent to prevent moisture evaporation of products such as creams.

Soy protein, fiber, fat, etc. are removed from soybean. What refine | purified the protein part to 90% or more is called SPI (separated soybean protein). There are two methods for separating and purifying soy protein: chemical fractionation and physical fractionation. It is widely used as a food ingredient because of its stability and safety. It has excellent water retention, emulsifying properties, and gel-forming properties, and is also used in cosmetics as a moisturizing agent, emulsion stabilizer and the like.

A soybean protein hydrolyzate and defatted soybean for foods are dispersed in water and the pH is adjusted with sodium hydroxide, and then hydrolyzed by adding a protease protease trypsin. After decomposition, the mixture is filtered, the filtrate is concentrated and cooled, and hydrochloric acid is added. A pale yellow to brown liquid with a slightly unique odor. It is also used in cosmetics as a humectant and an emulsion stabilizer.

Natto extract (fermented soybean fermented metabolite), a bio ingredient based on soybean. A mixture of glutamic acid polypeptide and fructose polymer. It is an excellent moisturizing ingredient that keeps the skin moisturized for a long time. Moisturizing effect comparable to hyaluronic acid.

Alpha hydroxy acid (AHA), alpha hydroxy acid, is a kind of acid contained in plants and fruits, and acts on old keratin on the skin surface, and has an effect of promoting keratinization (metabolism). This substance may be abbreviated as AHA for the initial. A kind of organic acid that exists widely in nature, such as glycolic acid, lactic acid, citric acid, tartaric acid and malic acid. In the 1970s, it was recognized by J-Middleton that lactic acid, which is one of the alphahydroxy acids, penetrated into the keratin and had the effect of relieving the dry and hard skin condition. E-Van Scott has also found that lactic acid is effective for shark skin. Lactic acid is contained in the composition of NMF as about 12% as a lactate. It has been proved that glycolic acid, which is also one of alpha hydroxy acids, has an effect of improving wrinkles. In addition, glycolic acid and lactic acid have a moisturizing effect that works on keratinocytes to promote normalization of keratinization, and exfoliation effect that drains old keratin and moisture balance.

It is an extract obtained by extracting with water from mixed mucus extract (multi-fruit, BSC), berries, orange and lemon fruits, sugar cane stem and sugar maple sap. Its components mainly consist of lactic acid, glycolic acid and citric acid. Since this mixed fruit acid contains a lot of topical alphahydroxy acids, it can be expected to have an effect of normalizing keratinization along with its moisturizing effect.

It is a component present in glycolic acid, sugar cane, immature grapes and leaves. It can be obtained by hydrolyzing chloroacetic acid or by allowing nitrous acid to act on glycine. White crystals or crystalline powder. It is hygroscopic and is used in cosmetics as a pH adjuster. In addition, fibroblasts producing collagen, elastin, and the like are proliferated to produce dermal connective tissue, thereby improving wrinkles.

Malic acid, naturally found in fruits such as apples. A synthetic product is obtained by heating fumaric acid with an alkali and adding water. Alternatively, it can also be obtained by reduction of glucose or hydrolysis of brom succinic acid. White crystals or crystalline powder with no odor or slightly unique odor. Diisostearyl malate, which is an ester of malic acid, is a highly viscous liquid, is mild and is widely used in cosmetics as an oily component. In addition, sodium malate has a salty taste and has been used as a substitute for salt since ancient times.
In cosmetics, it is used in soaps, shampoos, rinses, lotions and creams.

This is a product obtained by further adding glycerin to an extract obtained by extraction from seaweed extract, brown algae, Hibamata, Kombu, etc., or red algae. It contains components such as mucous polysaccharides (polysaccharides), amino acids, minerals, and alginic acid. Excellent moisturizing effect and skin regenerating effect. Kombu seaweed extract promotes lipolysis, and Hibamata seaweed extract promotes blood circulation, promotes metabolism of water and waste products, and is applied to slimming cosmetics in the hope of reducing cellulite. Yes.

Brown algae extract, there are about 20,000 kinds of seaweed in the world. In Japan, the following four types of plum algae extracts are classified according to the type of seaweed and the extraction method. Seaweed extract (1) An extract extracted from whole algae of brown algae or mekabu (spore leaves or mature leaves) with water, utanol, various polyhydric alcohols or a mixture thereof, and mainly contains amino acids. Seaweed extract (2) An extract extracted from the whole algae of brown algae with a sodium chloride solution and mainly composed of alginic acid. Seaweed extract (3) An extract extracted with water from all algae belonging to the genus Kombu belonging to brown algae and Aegis belonging to red algae, and mainly composed of alginic acid and carrageenan. Seaweed extract (4) An extract extracted from all algae of brown algae, red algae and green algae with a butylene glycol solution.

It is a grayish white to gray powder composed of sulfur-containing aluminum silicate (marine clay), mainly hydrous aluminum silicate containing sulfur. It consists of degradation products of animals and plants that have accumulated on the seabed or lake bottom since ancient times, and minerals and components that have collapsed the soil. There are sea mud, peroid, mylonite nekton, mud mud, etc., and in Europe it has been applied for a long time to marine therapy (thalassotherapy) and spa therapy. Cosmetics include cleansing and packs that make use of the mud's superior sucker effect. The mud adsorption effect has the effect of removing pore dirt and excess sebum. In addition, valuable trace elements of various minerals help skin homeostasis and smooth skin texture.

Mironite Nekton (marine clay, marine soft mud), a dried sea mud composed mainly of hydrous aluminum silicate containing sulfur. It is a light porous white powder mined from the Tanagura crushing zone that stretches east and west in Tanagura Town, Fukushima Prefecture. The marine animals and plants of tens of millions of years ago were buried and deposited by the action of microorganisms, and repeatedly decomposed, metabolized and re-synthesized over time. is there. It contains calcium oxide, iron oxide, magnesium oxide, sulfur, phosphorus, titanium oxide in addition to aluminum oxide and silicon dioxide, and is different from general clay minerals. Because of its excellent adsorption effect, it is applied to cleansing and packing agents that remove pore dirt and excess sebum. A small amount of iron oxide and a small amount of sulfur also have an anti-inflammatory effect. In addition, valuable trace elements of various minerals help skin homeostasis and smooth skin texture.

It is a mixture of inorganic salt obtained from seawater dried and seawater, and consists of sodium chloride, magnesium chloride and potassium chloride. There are Oligomer and Sea Mineral Rich, which are reduced to less than half sodium chloride by the seawater concentration method. Dead Sea salt is also applied to cosmetics as a dried natural seawater. It is blended in basic cosmetics, body cosmetics and bath preparations. Sodium, potassium, magnesium, calcium, and many other trace ion components give energy to skin cells and promote skin metabolism and moisture. Also, body care is expected to have a slimming effect and a beautiful skin effect due to the drainage of water in the body. In Europe, thalassotherapy (marine therapy) using sea mud and seaweed is popular.

Bittern powder, natural seawater component, mainly containing magnesium chloride. Moisturizes the stratum corneum and prevents skin dryness. It is a cosmetic ingredient used for thalassotherapy.

Magnesium chloride exists in seawater as a component of bitter juice. Used as a coagulant for tofu. NMF substance (natural moisturizing factor) contained in the skin and has a high heat retention effect without stickiness.

Marine collagen, water-soluble collagen extracted from cod float. It is a colorless to light yellowish brown liquid with a unique odor. Collagen extracted from marine organisms and has a moisturizing effect.

Yeast extract and yeast are a group of unicellular fungi. It has strong fertility and fermenting power, and has the power to break down sugar into alcohol and carbon dioxide. Yeast extract is a light yellow to brown powder or liquid, and the following five types are blended in cosmetics. 1. 1. spray-dried digestive juice obtained by yeast autolysis, 2. Digested liquid obtained by self-digestion of dry yeast aseptically filtered through a microfilter, lyophilized and diluted (purified) with purified water. 3. A digestion solution obtained by self-digestion of yeast can be extracted with propylene glycol, 1,3-butylene glycol and purified water from a concentrated and dried solution. 4. A product obtained by extracting yeast cells from powder and extracting them with a mixture of purified water and concentrated glycerin. What is obtained by hydrolyzing yeast with acid, and then centrifuging, dialysis, filtration, and concentration. Yeast extract contains components such as various amino acids, pitamine, nucleic acid-related substances, minerals, organic acids, proteins, carbohydrates, and lipids. It has a moisturizing action and cell activation action, and is used in creams, skin lotions, hair cosmetics and the like.

Dry yeast, yeast cells are dried and powdered. Pale yellowish white to brown powder with unique smell and taste. Yeast was said to have been used for medical purposes in the Greek and Roman eras, and with the progress of biochemistry, the medicinal properties of yeast were recognized in this century. Dry yeast contains components such as vitamins, minerals, amino acids, proteins, sugars, and nucleic acid-related substances. Cosmetics are formulated into basic cosmetics such as lotions, creams and packs, shampoos and rinses.

It is made by fermentation using pullulan and black yeast. It is a water-soluble polysaccharide in which about 1000 glucoses are regularly connected. It has many hydroxyl groups, dissolves well in both hot and cold water, and has excellent moisture retention. Used to enhance the functionality and feel of various cosmetics.

SK2 Pitera (fermented yeast metabolite), a fermented metabolite produced by yeast called SK2 Pitera. This secreted metabolite is mixed with various amino acids, organic acids, water-soluble polysaccharides and proteins. . These components are rich in hydrophilicity and show excellent moisture retention. Therefore, there is an effect of replenishing skin NMF component and activating skin metabolism. In addition, since it contains various organic acids, it has an astringent action and a lipid secretion control action. This SK2 Pitera was the first case in which a foreign-affiliated manufacturer formulated this catch phrase “fermented metabolite” at the end of 1980, and the word “bio” appeared in cosmetics.

Lactic acid bacteria culture solution (natural SE solution) and lactic acid bacteria are known to control enteric bacteria and have an intestinal regulating effect, and are also used daily as lactic acid drinks. Already in Roman times, it was said that it was used for the purpose of whitening the skin with animal milk and fermented milk, and preventing the skin from drying out. A lactic acid bacteria culture solution is obtained from a kind of lactic acid bacteria by fermentation, and its components are composed of amino acids, soluble proteins, organic acids, saccharides and the like. SE stands for skin care essence or shirota essence. It has a moisturizing action and pH control action to prevent skin dryness, keeps it glossy, and keeps the skin weakly acidic. In addition, it has an antioxidant effect, suppresses the formation of lipid peroxides that cause spots and freckles, enhances skin metabolism, and prevents aging.

Bifidobacteria extract (culture B, B), an aqueous solution of an extract obtained from Pifidobacterium. Pifidobacterium is a bacterium that propagates physiologically in the intestinal tract, but it produces lactic acid to increase the acidity in the intestine and plays a role in preventing the growth and growth of pathogenic bacteria. It was also revealed that Pifidobacterium has immunostimulatory action and anticancer activity. The culture of Pifidobacterium is applied to basic cosmetics as a biocomponent that enhances the natural repair function of cells damaged by ultraviolet rays and aging, and regenerates the cells that have deteriorated.

Trehalose, yeast, red algae, lichen, and other ingredients that exist in nature. In recent years, it has been attracting attention as a sugar having a high moisturizing effect, and has been found to have an action of protecting cells from a dry environment. Sulfated trehalose obtained by sulfating trehalose was found to increase the water retention function of the stratum corneum in a continuous application effect test on the skin.

This invention makes it a subject to provide the composition which has the effect | action of rough skin prevention, the cosmetics containing it, and a drink.

The cucumber is native to the Himalayas and was introduced to Japan via China at the end of the 9th century. It is called cucumber because it is introduced from Hu. There are more than 400 cucumber varieties in the world, but what is cultivated in Japan is called “Shirobo”. The white cucumber has an elongated shape, with a small thorn on the surface of the skin, and the part of the stab is white. Burning tanned skin with grated cucumber will cause a hot flash. Also, for burns and sweats, sticking a thin slice of cucumber has the effect of cooling the skin. Shibori soup has the effect of stretching the wrinkles on the face.

In the method for producing cucumber juice (cucumber fruit of cucurbitaceae) used in the present invention, the varieties, origin, maturity, size, etc. of the raw material cucumber fruit can be freely selected. In addition, two or more kinds of cucumber fruits having different varieties, production areas, maturity levels, sizes and the like can be blended as raw materials.

In general, ginseng used for medicine is different from carrot used for food. From the botanical viewpoint, the former is the original plant of Panax ginseng, and the latter is the celery family. Other species of the genus Carrot family that are the same as medicinal ginseng are bamboo ginseng (Toshibaninjin), Western (American ginseng) 37 (Sanshininjin), these are also used for medicinal purposes, but each has a slightly different component, The efficacy and effects are also different.

Panax Ginseng, a perennial perennial plant of the araliaceae family, originally grows deep in the mountains, is extremely difficult to cultivate, and has been prized since ancient times for its remarkable efficacy. An important component is the saponin of various glycosides. Saponin, also called ginsenoside, is said to have effects such as regulating the functions of the body, increasing the defense ability of the body, preventing aging, and enhancing the ability of mental and physical activities. Perennial plant of Araliaceae. Active ingredients such as carrot saponin widen peripheral blood vessels and improve blood circulation. As a main component of carrot, triterpenoid saponin (0.7 to 3%), ginsenosides, acetylene compound, panaxane and sesquiterpene are included.

Peach (Prunus persica) Rosaceae are as rich in vitamins as milk. Vitamin E is abundantly contained in peach (0.7mg / 100g), and has a preventive effect on lifestyle-related diseases such as diabetes, arteriosclerosis, Alzheimer's disease and aging. Niacin is contained in 0.6 mg of peach. Niacin is involved in many redox reactions. Therefore, niacin is indispensable for the metabolism of carbohydrates, lipids, and proteins, and plays the same role as vitamin B2.

It can be obtained by using peach (Rosaceae) leaves as a raw material and using a suitable extraction solvent in accordance with a conventional method. As a raw material, it is preferable to use a product obtained by crushing or pulverizing a dried plant product. As the extraction solvent, for example, water, a water-soluble organic solvent, or a mixed solvent thereof can be used. Examples of the aqueous organic solvent include lower alcohols such as methanol, ethanol, and isopropanol. Use of an aqueous organic solvent is preferable from the standpoint of preventing corruption of the extract and the efficiency of extraction. The ratio in the case of using a mixed solvent of water and an organic solvent as an extraction solvent can be appropriately set according to the kind of raw material, etc., for example, the organic solvent is 50% (v / v) or less, preferably 30% ( v / v) can be: Extraction can be repeated 2 to 3 times by using the extraction solvent as described above, for example, about 1 to 100 times the volume of the raw material, preferably about 2 to 5 times the volume, heating as necessary. .

Camomile (German Chamomile) Japanese wild chrysanthemum, flowers contain beautiful blue essential oil. It grows naturally in Europe and has been used as a treatment for various diseases since ancient times. In addition to insomnia, it has sedative effects and is used for various medicinal products such as eczema, eye drops, fragrances and tea. German chamomile is a blue essential oil, flavonoid, proazulene, coumarin, amino acid, choline, camazulene, β pisapolol, en ein dicycle ether is an active ingredient with anti-inflammatory, anti-bacterial and anti-convulsant effects of chamomile Is considered part of

Active components such as phytostimulin and flavonoids in beech buds have the power to promote plant cell metabolism and lead to flowering. Extracts extracted from beech buds have a moisturizing effect.

Examples of the beech family beech plant used in the present invention include Fagus crenata Blume, Fagus japonika Maxim, Fagus japonika Maxim, and American beech family belonging to the same family. (Fagus grandifolia), the same genus European beech (Fagus sylvatica L.), the same genus same fern beech (Fagus sylvatica L.var. Orient beech (Fagus
orientalis Lipsky). As these plants, buds, flowers, stems, leaves, fruits, seeds, roots, whole plants and the like are used. The extraction method is not particularly limited. For example, a single solvent usually used for producing cosmetic raw materials such as water, ethanol, methanol, propanol, butanol, and hydrophilic organic solvents such as 1,3-butylene glycol. Alternatively, a mixture is used.

In addition to the above-described components, the cosmetics of the present invention can be blended with other components that are usually used in external preparations for skin, such as cosmetics and pharmaceuticals, as long as the effects of the present invention are not impaired. Examples of such components include powder components such as adenosine triphosphate-disodium, tranexamic acid, titanium dioxide, mica, talc, avocado oil, corn oil, olive oil, rapeseed oil, evening primrose oil, castor oil, sunflower oil , Tea seed oil, rice bran oil, jojoba oil, cacao oil, coconut oil, squalane, squalene, beef tallow, owl, beeswax, candelilla wax, carnauba wax, whale wax, lanolin, silicone oil, fluorine oil, liquid paraffin, ceresin, petrolatum Oils such as polyoxyethylene (8 mol) oleyl alcohol ether, glyceryl monooleate, higher alcohols such as capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, sterols such as cholesterol and phytosterol, capric acid, laur Acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, linolenic acid, and other higher fatty acids, paraaminobenzoic acid, homomenthyl-7N-acetylalananthanilate, butylmethoxybenzoylmethane, di-paramethoxy UV absorbers such as cinnamic acid-glyceryl mono-2-ethylhexanoate, amyl salicylate, octyl cinnamate, 2,4-dihydroxybenzophenone, moisturizers such as polyethylene glycol, glycerin, sorbitol, xylitol, maltitol, methylcellulose, Thickeners such as ethyl cellulose, gum arabic, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyvinyl alcohol, montmorillonite, laponite, ethanol, 1,3-butylene Organic solvents such as recall, antioxidants such as butylhydroxytoluene, tocopherol and phytic acid, benzoic acid, salicylic acid, sorbic acid, alkyl esters of paraoxybenzoic acid (ethyl paraben, butyl paraben, etc.), antibacterial preservatives such as hexachlorophene, Amino acids such as glycine, alanine, valine, leucine, serine, threonine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamine, taurine, arginine, histidine and their alkali metal salts and hydrochlorides, acyl sarcosine acids (eg, lauroylmethyl sarcosine sodium) Etc.), organic acids such as glutathione, malic acid, tartaric acid, vitamin A and its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 And derivatives thereof, vitamin B such as vitamin B12, vitamin B15 and derivatives thereof, ascorbic acid, ascorbic acid sulfate (salt), ascorbic acid phosphate (salt), vitamin C such as ascorbic acid dipalmitate, α-tocopherol , Β-tocopherol, γ-tocopherol, vitamin E acetate such as vitamin E acetate, vitamin E nicotinate, vitamin D, vitamin H, vitamins such as pantothenic acid, pantethine, nicotinamide, benzyl nicotinate, γ-oryzanol, Allantoin, glycyrrhizic acid (salt), glycyrrhetinic acid and its derivatives, hinokitiol, mucidin, bisabolol, eucalyptol, thymol, inositol, saponins (such as saikosaponin, hetimasaponin, muclodisaponin, etc.) , Pantothenyl ethyl ether, ethinyl estradiol, cephalanthin, placenta extract, arbutin and other drugs, sorbitan monolaurate, sorbitan monopalmitate, sorbitan sesquioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polystearic acid poly Nonionic surface activity such as oxyethylene sorbitan, polyethylene glycol monooleate, polyoxyethylene alkyl ether, polyglycol diether, lauroyl diethanol amide, fatty acid isopropanol amide, maltitol hydroxy fatty acid ether, alkylated polysaccharide, alkyl glucoside, sugar ester Agent, stearyltrimethylammonium chloride, benzalkonium chloride, lauryla Cationic surfactants such as minoxide, sodium palmitate, sodium laurate, sodium lauryl sulfate, potassium lauryl sulfate, alkyl sulfate triethanolamine ether, funnel oil, linear dodecylbenzene sulfate, polyoxyethylene hydrogenated castor oil maleic acid, Anionic surfactants such as acylmethyl taurine, amphoteric surfactants, fragrances, purified water and the like can be blended.

As a result of intensive studies, the present inventors have found that when cucumber juice is combined with one or more of carrot extract, peach leaf extract, chamomile flower extract, and beech bud extract, the composition has an effect of preventing rough skin. I discovered that. That is, the gist of the present invention is as follows.
(1) A composition having an effect of preventing rough skin, characterized by containing one or more of cucumber juice, carrot extract, peach leaf extract, chamomile flower extract, and beech bud extract.
(2) A cosmetic having an effect of preventing rough skin, characterized by containing the above composition.
(3) A beverage having an effect of preventing rough skin, characterized by containing the above composition.

It is possible to provide a composition that is safe, has no side effects, and has an action / effect for preventing rough skin, a cosmetic, and a beverage.

A composition having an effect of preventing rough skin, characterized by containing one or more of carrot extract, peach leaf extract, chamomile flower extract, and beech bud extract based on cucumber juice. And it is set as the cosmetics or drink which has the use for a rough skin prevention characterized by containing the composition.

EXAMPLES The present invention will be described below with reference to examples, but the present invention is not limited to the examples.

In the present invention, the whole pulp of cucumber containing pulp is crushed using a homogenizer (manufactured by Daito Food Machinery Co., Ltd.) to obtain cucumber juice, filtered, and concentrated under reduced pressure to obtain a 5-fold concentrate (cucumber) Juice).

In this example, the carrot extract refers to 100 g of dried ginseng (Armyceae) in 1 L of 60 ° C. hot water, extracted for 2 days and nights, and after centrifugation, separated into an extract and a residue. About 5 times the amount of hot water at 100 ° C is added again, extraction is performed for one day, and after centrifugation, the mixture of the extract extracted at 60 ° C and the extract extracted at 100 ° C is used as the koji extract. The extract was filtered and then concentrated under reduced pressure to obtain 10 g of extract (carrot extract).

In this example, the following procedure was performed. Put 100g of dried and crushed peach leaves in 1L of 60 ° C hot water, extract 2 days and nights, and after centrifugation, separate into extract and residue, add the residue again about 5 times amount of 100 ° C hot water. Extraction was carried out for one day and night, and after centrifugation, a mixture of the extract extracted at 60 ° C. and the extract extracted at 100 ° C. was used as a koji extract. After filtering this extract, it was concentrated under reduced pressure and 10 g Extract (peach leaf extract).

In this example, the following procedure was performed. 100 g of dried and crushed chamomile flowers are put in 1 L of 60 ° C. hot water, extracted for two days and nights, and after centrifugation, the extract is separated from the residue, and the residue is added about 5 times the amount of 100 ° C. hot water again. Extraction was performed one day and night, and after centrifugation, the mixture of the extract extracted at 60 ° C. and the extract extracted at 100 ° C. was used as the extract. After filtering this extract, it was concentrated under reduced pressure and 10 g An extract was obtained (camomile flower extract).

In this example, the following procedure was performed. Put 100g of dried and ground beech buds in 1L of 60 ° C hot water, extract it for 2 days and night, and after centrifugation, separate it into the extract and the residue. Add about 5 times the amount of 100 ° C hot water again. The mixture was extracted for one day and night, centrifuged, extracted at 60 ° C. and extracted at 100 ° C. The resulting extract was filtered, concentrated under reduced pressure, and 10 g Extract (beech bud extract).

A cosmetic having the following composition was prepared. Numbers indicate weight percent.
Formulation Example 1
Cucumber juice 1.0
Carrot extract 1.0
Peach leaf extract 1.0
Chamomile flower extract 1.0
Beech bud extract 1.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Fragrance Appropriate amount of purified water Residual manufacturing method: Heating, stirring, dissolving while keeping at 80 ° C., cooling to 20 ° C. with stirring.

Formulation Example 2
Cucumber juice 4.0
Carrot extract 1.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

Formulation Example 3
Cucumber juice 4.0
Carrot extract 0.0
Peach leaf extract 1.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

Formulation Example 4
Cucumber juice 4.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 1.0
Beech bud extract 0.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

Formulation Example 5
Cucumber juice 4.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 1.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

Formulation Example 6
Cucumber juice 5.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

Formulation Example 7
Cucumber juice 0.0
Carrot extract 5.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

Formulation Example 8
Cucumber juice 0.0
Carrot extract 0.0
Peach leaf extract 5.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

Formulation Example 9
Cucumber juice 0.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 5.0
Beech bud extract 0.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

Formulation Example 10
Cucumber juice 0.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 5.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

Formulation Example 11
Cucumber juice 0.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Propylene glycol 1.0
Citric acid 0.04
Sodium citrate 0.04
Ethanol 10.0
Methylparaben 0.1
Perfume Appropriate amount of purified water

About evaluation of the rough skin prevention of the cosmetics of the said mixing | blending, it carried out as follows. Using Formulation Example 1 to Formulation Example 11 prepared according to the above example by 10 general panelists (30 to 60 year old women), using 3 ml twice a day for 1 month per day The “feel of skin after drinking” was evaluated based on the following evaluation criteria. Table 1 shows the evaluation results of 10 people.

Evaluation standard ◎: The skin became quite moisturized. ○: The skin became moist. △: The skin became slightly moist. ×: The skin. There was no particular change in feeling

[Table 1]
Panel a b c de f gh i j
Formulation Example 1 ○ ◎ ○ ◎ ◎ ◎ ○ ◎ ◎ ◎
Formulation Example 2 ◎ ○ ◎ ○ ○ ◎ ○ ◎ ◎ ◎
Formulation Example 3 ○ ◎ ○ ◎ ○ ○ ◎ ○ ○ ◎
Formulation Example 4 ◎ ○ ◎ ◎ ○ ◎ ◎ ○ ◎ ○
Formulation Example 5 ○ ◎ ◎ ○ ○ ○ ○ ○ ◎ ○ ○
Formulation Example 6 △ ○ ○ ◎ × ○ ○ ○ × ×
Formulation Example 7 × ◎ × ○ ○ △ ○ × ○ ○
Formulation Example 8 ○ × ◎ ○ × △ × ○ × ◎
Formulation Example 9 ○ ◎ ○ × ○ × ○ × △ ○
Formulation Example 10 ○ ○ ○ ○ △ × ○ ○ ○ ○
Formulation Example 11 × × × × △ × × × × △

The composition of the beverage used in the test is shown below.

A beverage having the following composition was prepared. Numbers indicate weight percent.
Formulation example A
Cucumber juice 4.0
Carrot extract 1.0
Peach leaf extract 1.0
Chamomile flower extract 1.0
Beech bud extract 1.0
Citric acid 0.4
Sugar 5.0
Purified water Residual production method: While maintaining at 80 ° C, the mixture was heated, stirred, dissolved, and cooled to 20 ° C.

Formulation example B
Cucumber juice 4.0
Carrot extract 4.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Citric acid 0.4
Sugar 5.0
Purified water residue

Formulation example C
Cucumber juice 4.0
Carrot extract 0.0
Peach leaf extract 4.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Citric acid 0.4
Sugar 5.0
Purified water residue

Formulation example D
Cucumber juice 4.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 4.0
Beech bud extract 0.0
Citric acid 0.4
Sugar 5.0
Purified water residue

Formulation example E
Cucumber juice 4.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 4.0
Citric acid 0.4
Sugar 5.0
Purified water residue

Formulation Example F
Cucumber juice 8.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Citric acid 0.4
Sugar 5.0
Purified water residue

Formulation example G
Cucumber juice 0.0
Carrot extract 8.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Citric acid 0.4
Sugar 5.0
Purified water residue

Formulation example H
Cucumber juice 0.0
Carrot extract 0.0
Peach leaf extract 8.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Propylene glycol 0.0
Citric acid 0.4
Sugar 5.0
Purified water residue

Formulation Example I
Cucumber juice 0.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 8.0
Beech bud extract 1.0
Citric acid 0.4
Sugar 5.0
Purified water residue

Formulation example J
Cucumber juice 0.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 8.0
Citric acid 0.4
Sugar 5.0
Purified water residue

Formulation example K
Cucumber juice 0.0
Carrot extract 0.0
Peach leaf extract 0.0
Chamomile flower extract 0.0
Beech bud extract 0.0
Propylene glycol 0.0
Citric acid 0.4
Sugar 5.0
Purified water residue

About evaluation of the rough skin prevention of the drink of the said mixing | blending, it was as follows. 10 general panelists (30 to 60 year old women) ingested 100 ml of a total of 100 ml per day for 1 month each of Formulation Examples A to K prepared according to the above examples. The “feel of skin after drinking” was evaluated based on the following evaluation criteria. Table 2 shows the evaluation results of 10 people.

Evaluation standard ◎: The skin became quite moisturized. ○: The skin became moist. △: The skin became slightly moist. ×: The skin. There was no particular change in feeling

[Table 2]
Panel a b c de f gh i j
Formulation example A ◎ ○ ◎ ◎ ○ ◎ ○ ○ ◎ ◎
Formulation example B ○ ◎ ◎ ○ ◎ ○ ○ ◎ ○ ◎
Formulation example C ◎ ◎ ○ ◎ ○ ○ ◎ ◎ ○ ○
Formulation example D ○ ◎ ◎ ○ ○ ◎ ○ ○ ◎ ◎
Formulation Example E ○ ◎ ○ ◎ ○ ○ ○ ◎ ◎ ○
Formulation Example F ○ ○ △ ◎ × ○ ○ ○ × ×
Formulation example G × ◎ × △ ○ △ ○ × △ ○
Formulation Example H ○ × ○ ○ × △ × ○ × ◎
Formulation Example I ◎ ○ ○ × ○ × ○ × △ ○
Formulation Example J △ ○ △ ○ △ × ○ ○ ○ ○
Formulation example K × × △ × × × × × × × ×

In the above, no panelists complained of symptoms such as skin irritation such as pain and itchiness and allergic reaction in the group in which any of the formulation examples were drunk.

Claims (3)

A composition having an effect of preventing rough skin, characterized by containing one or more of cucumber juice, carrot extract, peach leaf extract, chamomile flower extract, and beech bud extract. A cosmetic having an effect of preventing rough skin, comprising the composition according to claim 1. A beverage having a rough skin-preventing action, comprising the composition according to claim 1.