CN113827764A - Medical dressing for postoperative repair based on globefish skin collagen - Google Patents
Medical dressing for postoperative repair based on globefish skin collagen Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
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Abstract
A globefish skin collagen-based postoperative repair medical dressing is characterized by comprising a gel layer and a non-woven fabric layer; the gel layer comprises the following formula: 40-95 parts of solvent, 0.1-2 parts of collagen, 0.05-0.1 part of DNA sodium, 0.01-1 part of asiaticoside, 1-20 parts of schizosaccharomyces fermentation product lysate, 1-25 parts of schizosaccharomyces fermentation product filtrate, 0.01-0.1 part of dipotassium glycyrrhizinate, 0.05-0.1 part of vitamin C, 0.1-4 parts of vitamin E acetate, 0.1-4 parts of tranexamic acid, 0.1-4 parts of thickening agent, 0.1-4 parts of pH regulator and 0.1-5 parts of antiseptic bacteriostatic agent; according to the invention, the probiotics extract, the microecological preparation, the collagen, the ceramide, the vitamin, the glucan and the like are matched, so that the cell generation and the arrangement are accelerated, the wet dressing environment is provided, the wound healing is promoted, the scar is reduced, the anti-inflammatory repair effect is achieved by adjusting the immunity, the melanin formation is reduced, and finally, a complete repair scheme is provided for the repair of postoperative injury by repairing the physical barrier and the microecological barrier of the epidermis.
Description
Technical Field
The invention relates to the field of medical dressings, in particular to a medical dressing for postoperative repair based on globefish skin collagen.
Background
At present, the shaping market at home and abroad is developed vigorously, China is the second largest shaping market second to the United states, and the latest popular shaping of lunch or micro-shaping is developed particularly rapidly. The american cosmetic society has found through research that for every doubling of income, the consumer demand for surgical orthopaedic surgery is reduced by 62%, while for micro-orthopaedic projects the consumer demand is increased by 463%. In the medical beauty consumer market of China, non-operative projects (namely micro-plastic) occupy 60% of the total income of medical and American industries with the advantages of relatively low risk, short recovery period and the like, the growth rate is up to 40%, and the rate is far higher than that of operative treatment projects. The two items of the micro plastic surgery, except for botulinum toxin and fillers (such as hyaluronic acid), are the most abundant ones, namely the hydro-acupuncture and the laser treatment, and the post-operative repair becomes a market for micro plastic surgery.
At present, sodium hyaluronate and collagen are used as main components of the postoperative repair dressing on the market, and the postoperative repair dressing is used as a wet dressing therapy to promote wound healing and is verified by researchers and the market. And the other scheme is that from the perspective of the material of the membrane cloth, the aim of improving the repair capability is fulfilled by improving the performance of the membrane cloth.
In fact, after operations such as laser acupuncture and laser surgery, repair of the skin, in addition to wounds, needs to be performed to repair barriers and relieve inflammation, and repair the micro-ecological structure of the epidermis, so as to achieve better performance, provide a satisfactory surgical plan for customers, shorten the post-operative repair time, and improve the plan effect, and thus a more comprehensive post-operative repair plan is urgently needed.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the postoperative medical dressing based on the globefish skin collagen can promote wound healing, reduce scars, achieve an anti-inflammatory repair effect and reduce melanin formation by adjusting immunity.
The technical scheme for solving the technical problems is as follows:
a medical dressing for postoperative repair based on globefish skin collagen comprises a gel layer and a non-woven fabric layer;
the gel layer comprises the following formula:
preferably, the collagen is derived from globefish skin.
Preferably, the DNA sodium is extracted from globefish milt, which is the testis of globefish.
Preferably, the solvent is selected from water.
Preferably, the thickener is selected from carbomers.
Preferably, the pH adjusting agent is selected from TEA.
Preferably, the thickener is selected from sodium hyaluronate or carbomer.
Preferably, the preservative bacteriostatic agent is selected from hydroxyacetophenone and hexanediol.
Preferably, the gel layer formulation is as follows:
preferably, the gel layer formulation is as follows:
the Chinese naming of the compound of the invention conflicts with the structural formula, and the structural formula is taken as the standard; except for obvious errors in the formula.
(1) The invention can repair wound rapidly through globefish skin collagen and globefish white DNA sodium.
(2) The invention utilizes the probiotic active substance and the lysate of the yeast fermentation product to promote the expression of TJs protein (tight junction protein) and quickly organize a cell barrier.
(3) The invention reduces the formation of melanin and reduces the skin blackening caused by inflammation through natural components such as vitamins, tranexamic acid and the like.
(4) The invention promotes the restoration of epidermal microecology by adding prebiotics components, such as the secondary fission yeast fermentation product filtrate.
Detailed Description
The invention is illustrated but not limited by the following examples. The technical solutions protected by the present invention are all the simple replacements or modifications made by the skilled person in the art.
Example 1:
the medical cold compress patch consists of a gel layer, a non-woven fabric and other substrates, wherein the preparation process of the gel layer is as follows:
weighing 93kg of purified water, placing in a water phase pot, adding 0.12kg of carbomer, uniformly dispersing, heating to 85 ℃, stirring, and keeping the temperature for half an hour; cooling to 65 ℃ after the carbomer is fully dissolved, and adding 0.12kg of TEA to adjust the pH to 6; cooling to below 45 deg.C, adding cracked yeast fermentation product lysate 1.5kg, cracked yeast fermentation product filtrate 3kg, vitamin C0.1 kg, vitamin E acetate 0.5kg, tranexamic acid 0.5kg, puffer fish skin collagen 0.1kg, globefish essence derived DNA sodium 0.05kg, asiaticoside 0.2kg, and dipotassium glycyrrhizinate 0.05 kg; adding 0.5kg of p-hydroxyacetophenone and 0.5kg of hexanediol, stirring for 0.5h, filtering, taking out of the pot, and filling the medical cold compress paste finished product.
Example 2:
after laser surgery is finished, a user uses the cold compress patch for 0.5-1 hour and then takes off the cold compress patch, and uses 1-2 pieces of the cold compress patch every day for 2 days.
Example 3:
after the water acupuncture operation is finished, a user uses the cold compress patch for 0.5 to 1 hour and then takes off the cold compress patch, and uses 2 to 3 pieces of cold compress patch every day for 3 days.
Example 4
Referring to example 1, a gel layer was prepared, wherein the raw material addition amounts were adjusted to: 89kg of purified water, 0.22kg of carbomer, 0.22kg of TEA, 3kg of schizosaccharomyces cerevisiae fermentation product lysate, 4kg of schizosaccharomyces cerevisiae fermentation product filtrate, 0.2kg of vitamin C, 0.6kg of vitamin E acetate, 0.6kg of tranexamic acid, 0.2kg of puffer skin collagen, 0.1kg of DNA sodium from globefish sperm white, 0.2kg of asiaticoside, 0.1kg of dipotassium glycyrrhizinate, 1kg of hydroxyacetophenone, 1kg of hexanediol and the balance of components.
Example 5
Referring to example 1, a gel layer was prepared, wherein the raw material addition amounts were adjusted to: 96kg of purified water, 0.05kg of carbomer, 0.15kg of TEA, 1kg of yeast fermentation product lysate of fission yeast, 2kg of yeast fermentation product filtrate of fission yeast, 0.05kg of vitamin C, 0.2kg of vitamin E acetate, 0.2kg of tranexamic acid, 0.1kg of puffer skin collagen, 0.05kg of DNA sodium from globefish white, 0.1kg of asiaticoside, 0.02kg of dipotassium glycyrrhizinate, 0.2kg of hydroxyacetophenone, 0.2kg of hexanediol and the balance of components are unchanged.
Comparative example 1
The dressing is prepared according to the scheme of example 1 of the CN111097066A patent.
Comparative example 2
The dressing is prepared according to the scheme of example 2 of the CN103989828A patent.
Example 6
The results of investigation of the recovery period and the degree of blackening after cold application using examples 1, 4, 5, comparative examples 1, and 2 were given to the laser surgery users and the hydro-acupuncture surgery users as follows:
according to clinical results, the recovery period is shortened after the medical dressing for postoperative repair is used, and the phenomenon of blackening does not occur or is only slightly caused after the operation. The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the inventive concept of the present invention, and these changes and modifications are all within the scope of the present invention.
Claims (9)
1. A globefish skin collagen-based postoperative repair medical dressing is characterized by comprising a gel layer and a non-woven fabric layer; the gel layer comprises the following formula:
2. a medical dressing for postoperative rehabilitation based on puffer fish skin collagen is characterized by comprising a gel layer and a non-woven fabric layer; the gel layer comprises the following formula:
3. a globefish skin collagen-based postoperative repair medical dressing is characterized by comprising a gel layer and a non-woven fabric layer; the gel layer comprises the following formula:
4. the medical dressing for post-operative repair based on puffer fish skin collagen according to any one of claims 1 to 3, wherein the collagen is derived from puffer fish skin.
5. The medical dressing for post-operative repair based on puffer fish skin collagen according to any one of claims 1 to 3, wherein said DNA sodium is extracted from puffer fish milt.
6. The puffer fish skin collagen-based postoperative repair medical dressing according to any one of claims 1 to 3, wherein the solvent is selected from water.
7. The puffer fish skin collagen-based postoperative repair medical dressing according to any one of claims 1 to 3, wherein the thickening agent is selected from carbomers.
8. The medical dressing for post-operative repair based on puffer fish skin collagen according to any one of claims 1 to 3, wherein the pH adjusting agent is selected from TEA.
9. The medical dressing for postoperative repair based on puffer fish skin collagen according to any one of claims 1 to 3, wherein the antiseptic bacteriostatic agent is selected from hydroxyacetophenone and hexanediol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110932061.1A CN113827764A (en) | 2021-08-13 | 2021-08-13 | Medical dressing for postoperative repair based on globefish skin collagen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110932061.1A CN113827764A (en) | 2021-08-13 | 2021-08-13 | Medical dressing for postoperative repair based on globefish skin collagen |
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| CN113827764A true CN113827764A (en) | 2021-12-24 |
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| CN202110932061.1A Pending CN113827764A (en) | 2021-08-13 | 2021-08-13 | Medical dressing for postoperative repair based on globefish skin collagen |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006219431A (en) * | 2005-02-10 | 2006-08-24 | Yukihiro Hirose | Composition having rough skin-preventing activity, cosmetic and beverage |
| JP2007211183A (en) * | 2006-02-10 | 2007-08-23 | Katakura Chikkarin Co Ltd | Puffer fish-originated collagen, derivative thereof and method for producing the same, and cosmetic containing the collagen and derivative thereof |
| CN107648168A (en) * | 2017-10-31 | 2018-02-02 | 福建师范大学 | A kind of filefish fish collagen protein facial mask liquid and preparation method thereof |
| CN109464316A (en) * | 2019-01-07 | 2019-03-15 | 广州市拓瑞科技有限公司 | Skin conditioning composition, Medical cold application with antiallergic anti-inflammatory effect and preparation method thereof |
| CN110760509A (en) * | 2019-07-03 | 2020-02-07 | 深圳瑞达生物股份有限公司 | Method for extracting milt component of globefish testis |
| CN112294673A (en) * | 2020-09-30 | 2021-02-02 | 华仁健康产业(青岛)有限公司 | Whitening mask and preparation method thereof |
| CN112315843A (en) * | 2020-12-03 | 2021-02-05 | 广东嘉丹婷日用品有限公司 | Whitening and freckle removing essence and preparation method thereof |
-
2021
- 2021-08-13 CN CN202110932061.1A patent/CN113827764A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006219431A (en) * | 2005-02-10 | 2006-08-24 | Yukihiro Hirose | Composition having rough skin-preventing activity, cosmetic and beverage |
| JP2007211183A (en) * | 2006-02-10 | 2007-08-23 | Katakura Chikkarin Co Ltd | Puffer fish-originated collagen, derivative thereof and method for producing the same, and cosmetic containing the collagen and derivative thereof |
| CN107648168A (en) * | 2017-10-31 | 2018-02-02 | 福建师范大学 | A kind of filefish fish collagen protein facial mask liquid and preparation method thereof |
| CN109464316A (en) * | 2019-01-07 | 2019-03-15 | 广州市拓瑞科技有限公司 | Skin conditioning composition, Medical cold application with antiallergic anti-inflammatory effect and preparation method thereof |
| CN110760509A (en) * | 2019-07-03 | 2020-02-07 | 深圳瑞达生物股份有限公司 | Method for extracting milt component of globefish testis |
| CN112294673A (en) * | 2020-09-30 | 2021-02-02 | 华仁健康产业(青岛)有限公司 | Whitening mask and preparation method thereof |
| CN112315843A (en) * | 2020-12-03 | 2021-02-05 | 广东嘉丹婷日用品有限公司 | Whitening and freckle removing essence and preparation method thereof |
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Application publication date: 20211224 |