CN113827764A - 一种基于河豚鱼皮胶原的术后修复医用敷料 - Google Patents

一种基于河豚鱼皮胶原的术后修复医用敷料 Download PDF

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CN113827764A
CN113827764A CN202110932061.1A CN202110932061A CN113827764A CN 113827764 A CN113827764 A CN 113827764A CN 202110932061 A CN202110932061 A CN 202110932061A CN 113827764 A CN113827764 A CN 113827764A
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repair
medical dressing
skin collagen
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钱陈
甘毅
潘健
王会
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Beijing Jingrui Agricultural Science And Technology Development Co ltd
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Changzhou Aisikang Biomedical Co ltd
Changzhou Anmei Biotechnology Co ltd
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Abstract

一种基于河豚鱼皮胶原的术后修复医用敷料，其特征在于，包括凝胶层和无纺布层；其中凝胶层配方如下：溶剂40‑95份，胶原蛋白0.1‑2份，DNA钠0.05‑0.1份，积雪草苷0.01‑1份，二裂酵母发酵产物溶胞物1‑20份，二裂酵母发酵产物滤液1‑25份，甘草酸二钾0.01‑0.1份，维生素C0.05‑0.1份，维生素E醋酸酯0.1‑4份，传明酸0.1‑4份，增稠剂0.1‑4份，pH调节剂0.1‑4份，防腐抑菌剂0.1‑5份；本发明通过益生菌提取物，微生态制剂，搭配胶原蛋白，神经酰胺，维生素以及葡聚糖等不仅可以加速细胞生成以及排列整齐，同时提供了湿敷环境，促进伤口愈合，减少瘢痕，同时通过调节免疫力，起到抗炎修复效果，减少黑色素形成，最后通过修复表皮物理屏障和微生态屏障，对术后损伤的修复提供了一套完整的修复方案。

Description

一种基于河豚鱼皮胶原的术后修复医用敷料
技术领域
本发明涉及医用敷料领域，具体涉及一种基于河豚鱼皮胶原的术后修复医用敷料。
背景技术
目前国内外整形市场蓬勃发展，中国已经成为仅次于美国的第二大整形市场，而最新流行的午餐整形，或者叫微整形发展尤为迅速。美国整容协会通过研究得出，收入每提升一倍，消费者对于外科整形手术的需求就会降低62％，而对于微整形项目，消费者的需求则会提升 463％。在我国医疗美容消费市场中，非手术类项目(即微整形)以风险相对较低、恢复期短等优势占据了医美行业总收入的60％，增长率高达40％，远远高于手术治疗项目。而微整形手术中除了肉毒素和填充剂(如玻尿酸)之外，数量最大的两个项目是水光针和激光治疗，而术后修复成为微整形的一个刚需市场。
目前市场上有的术后修复敷料以透明质酸钠和胶原蛋白为主要成分，作为湿敷疗法，促进伤口愈合已经被研究者以及市场验证。而另外一种方案是从膜布材质角度出发，通过提高膜布的性能，从而达到提高修复能力的目的。
而事实上，在像水光针以及激光手术之后，修复需要解决的除了创伤之外，还需要解决修复屏障以及舒缓炎症，以及修复表皮的微生态结构，从而达到较好，为客户提供满意的手术方案，缩短术后修复时间，并且提高方案效果，因此急需一款更为全面的术后修复方案。
发明内容
本发明要解决的技术问题是：提供一种能够促进伤口愈合，减少瘢痕，同时通过调节免疫力，起到抗炎修复效果，减少黑色素形成的基于河豚鱼皮胶原的术后医用敷料。
本发明解决上述技术问题的技术方案如下：
一种基于河豚鱼皮胶原的术后修复医用敷料，包括凝胶层和无纺布层；
其中凝胶层配方如下：
Figure RE-GDA0003363734370000011
Figure RE-GDA0003363734370000021
优选的，所述胶原蛋白来自河豚鱼皮。
优选的，所述DNA钠提取自河豚精白，河豚精白为河豚的精巢。
优选的，所述溶剂选自水。
优选的，所述增稠剂选自卡波姆。
优选的，所述pH调节剂选自TEA。
优选的，所述增稠剂选自透明质酸钠或者卡波姆。
优选的，所述防腐抑菌剂选自羟基苯乙酮和己二醇。
优选的，所述凝胶层配方如下：
Figure RE-GDA0003363734370000022
优选的，所述凝胶层配方如下：
Figure RE-GDA0003363734370000023
本发明中化合物的中文命名与结构式有冲突的，以结构式为准；结构式有明显错误的除外。
(1)本发明通过河豚鱼皮胶原和河豚精白来源的DNA钠，快速修复创伤。
(2)本发明利用益生菌活性物，二裂酵母发酵产物溶胞物，提升TJs蛋白(紧密连接蛋白)的表达，快速组织细胞屏障。
(3)本发明通过维生素以及传明酸等天然成分，降低黑色素的形成，减少炎症导致的皮肤返黑。
(4)本发明通过添加益生元成分，如二裂酵母发酵产物滤液，促进表皮微生态的恢复。
具体实施方式
以下结合实例说明本发明，但不限制本发明。在本领域内，技术人员对本发明所做的简单替换或改进均属于本发明所保护的技术方案内。
实施例1：
本发明所述医用冷敷贴有凝胶层和无纺布等基质组成，其中凝胶层制备工艺如下：
称取93kg纯化水置于水相锅中，加入卡波姆0.12kg，分散均匀，升温至85℃后，搅拌保温半个小时；待卡波姆充分溶解后降温至65℃，加入TEA约0.12kg调节pH至6；降温至45℃以下，后加入二裂酵母发酵产物溶胞物1.5kg，二裂酵母发酵产物滤液3kg，维生素C0.1kg，维生素E醋酸酯0.5kg，传明酸0.5kg，河豚鱼皮胶原蛋白0.1kg，河豚精白来源的DNA钠0.05kg，积雪草苷0.2kg，甘草酸二钾0.05kg；加入对羟基苯乙酮0.5kg，己二醇0.5kg，搅拌0.5h后过滤出锅，灌装医用冷敷贴成品。
实施例2：
用户在做完激光手术后，使用冷敷贴0.5小时-1小时，然后取下，以后每天使用1-2片，坚持2天。
实施例3：
用户在做完水光针手术后，使用冷敷贴0.5小时-1小时，然后取下，以后每天使用2-3片，坚持3天。
实施例4
参考实施例1，配置凝胶层，其中原料添加量调整为：纯化水89kg，卡波姆0.22kg，TEA0.22kg，二裂酵母发酵产物溶胞物3kg，二裂酵母发酵产物滤液4kg，维生素C0.2kg，维生素E醋酸酯0.6kg，传明酸0.6kg，河豚鱼皮胶原蛋白0.2kg，河豚精白来源的DNA钠0.1kg，积雪草苷0.2kg，甘草酸二钾0.1kg，羟基苯乙酮1kg，己二醇1kg，其余成分不变。
实施例5
参考实施例1，配置凝胶层，其中原料添加量调整为：纯化水96kg，卡波姆0.05kg，TEA0.15kg，二裂酵母发酵产物溶胞物1kg，二裂酵母发酵产物滤液2kg，维生素C0.05kg，维生素E醋酸酯0.2kg，传明酸0.2kg，河豚鱼皮胶原蛋白0.1kg，河豚精白来源的DNA钠0.05kg，积雪草苷0.1kg，甘草酸二钾0.02kg，羟基苯乙酮0.2kg，己二醇0.2kg，其余成分不变。
对比例1
按照CN111097066A专利实施例1方案制备得到敷料。
对比例2
按照CN103989828A专利实施例2方案制备得到敷料。
实施例6
给激光手术用户和水光针手术用户使用实施例1、实施例4、实施例5、对比例1、对比例2的冷敷贴后，恢复期以及反黑程度的调查结果如下：
Figure RE-GDA0003363734370000041
根据临床结果显示，使用本发明的术后修复医用敷料后，恢复期有所缩短，且在术后未发生或只有轻微的返黑现象。以上所述的仅是本发明的优选实施方式，应当指出，对于本领域的普通技术人员来说，在不脱离本发明创造构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。

Claims (9)

1.一种基于河豚鱼皮胶原的术后修复医用敷料，其特征在于，包括凝胶层和无纺布层；其中凝胶层配方如下：
Figure FDA0003211386120000011
2.一种基于河豚鱼皮胶原的术后修复用医用敷料，其特征在于，包括凝胶层和无纺布层；其中凝胶层配方如下：
Figure FDA0003211386120000012
3.一种基于河豚鱼皮胶原的术后修复医用敷料，其特征在于，包括凝胶层和无纺布层；其中凝胶层配方如下：
Figure FDA0003211386120000013
Figure FDA0003211386120000021
4.根据权利要求1～3任一项所述的基于河豚鱼皮胶原的术后修复医用敷料，其特征在于，所述胶原蛋白来自河豚鱼皮。
5.根据权利要求1～3任一项所述的基于河豚鱼皮胶原的术后修复医用敷料，其特征在于，所述DNA钠提取自河豚精白。
6.根据权利要求1～3任一项所述的基于河豚鱼皮胶原的术后修复医用敷料，其特征在于，所述溶剂选自水。
7.根据权利要求1～3任一项所述的基于河豚鱼皮胶原的术后修复医用敷料，其特征在于，所述增稠剂选自卡波姆。
8.根据权利要求1～3任一项所述的基于河豚鱼皮胶原的术后修复医用敷料，其特征在于，所述pH调节剂选自TEA。
9.根据权利要求1～3任一项所述的基于河豚鱼皮胶原的术后修复医用敷料，其特征在于，所述防腐抑菌剂选自羟基苯乙酮和己二醇。
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