CN108888801A - A kind of medical adhesive with efficient anti-inflammatory hemostatic function - Google Patents
A kind of medical adhesive with efficient anti-inflammatory hemostatic function Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention discloses a kind of medical adhesives with efficient anti-inflammatory hemostatic function, which is characterized in that the component including following parts by weight：20-25 parts of a- alpha-cyanoacrylate n-octyl, a- alpha-cyanoacrylate be monooctyl ester 25-35 parts different, 2-6 parts of polyvinyl acetate, efficiently anti-inflammatory component 12-20 part, efficiently stop blooding component 13-23 parts, 3-6 parts of cell-activating agent MG-60,8-10 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizer, compound 150-220 parts of anti-inflammatory fruit oil ingredient, 200 parts of sterile water.Medical adhesive of the invention has especially selected a variety of extracts with anti-inflammatory hemostatic function and has been added to two big efficiently anti-inflammatory components and a component of efficiently stopping blooding to improve whole anti-inflammatory hemostasis, and adhesion strength is high, bleeding stopping period is short, meets the clinical application requirement to adhesive of medical.
Description
Technical field
The invention belongs to medical material tech fields, and in particular to a kind of medical adhesive with efficient anti-inflammatory hemostatic function.
Background technique
With the progress of medicine, the requirement clinically to surgical technic and auxiliary material effect is higher and higher.Modern medicine
Requirement to reduce the pain of patient to the maximum extent and to the maximum life support of patient, therefore in surgical procedure
Quick hemostasis and anti-inflammation is particularly important.Adhesive of medical is a branch of medical high polymer, it is viscous with biological tissue
Object is closed, human body overwhelming majority tissue, organ can replace part to suture using adhering technique over the course for the treatment of, ligation behaviour
Make, it is not necessary to anaesthetize；Automatic-falling after wound healing.It is compared with the traditional method, the use of adhesive of medical can effectively shorten operation
Time reduces patient pain, quick-acting haemostatic powder anti-inflammatory may be implemented and can quickly repair wound, guarantees beautiful.
The main direction of studying of adhesive of medical is to improve the adhesion strength of various adhesives at present, however outer at present
The bio-medical material applied in section's operation seldom has the effect of efficiently anti-inflammatory and extensive wound hemostasis.It is first during surgery
Hemostasis is first rapidly completed, could preferably transmit drug；With good antiphlogistic effects patient just can more safety and earlier
Into recovery state.The generation of formaldehyde generates secondary make to bio-tissue in the storage of cyanoacrylate medical adhesive, use process
With, and as the increase of concentration of formaldehyde increases the damage of organism, seriously affect the effect and application of adhesive of medical.
Summary of the invention
Based on the above prior art, the purpose of the present invention is to provide a kind of a variety of active principles of combination to greatly improve hemostasis
Rate and antiphlogistic effects, while the medical adhesive with efficient anti-inflammatory hemostatic function for effectively inhibiting formaldehyde to generate and its preparation side
Method.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of medical adhesive with efficient anti-inflammatory hemostatic function, which is characterized in that the component including following parts by weight：A- cyano
20-25 parts of n-octyl, a- alpha-cyanoacrylate be monooctyl ester 25-35 parts different, 2-6 parts of polyvinyl acetate, efficiently anti-inflammatory component
12-20 parts, efficiently component 13-23 parts of hemostasis, 3-6 parts of cell-activating agent MG-60,8-10 parts of allantoin, hydrolyzed wheat protein 1
Part, 1 part of stabilizer, compound 150-220 parts of anti-inflammatory fruit oil ingredient, 200 parts of sterile water；
The efficient anti-inflammatory component is calculated according to weight fraction, including 2 parts of abalone anti-inflammatory peptides, yunnan pine caterpillar pupa chitin 3
Part, 6 parts of radix scrophulariae polysaccharide, 5 parts of Lignum Xanthoceratis extract；
The efficient hemostasis component is calculated according to weight fraction, including 5 parts of RADIX SANGUISORBA extract, 3 parts of lithospermum euchromum Royle extract,
3 parts of potato gelsemium extract, charred NODUS NELUMBINIS RHIZOMATIS extract 6,6 parts of sophora flower charcoal processing extract；
The compound anti-inflammatory fruit oil ingredient, calculates according to weight fraction, including 4 parts of Chinese gooseberry seed oil, 3 parts of oil and fat of sacha inchi, Du
Secondary 2 parts and 5 parts of magnolia vine fruit oil of seed oil.
Further, the stabilizer is by polyanion cellulose and 2, and 6- di-tert-butyl-4-methy phenol is according to weight
Number 10：1 is composed.
Further, the RADIX SANGUISORBA extract in the efficient hemostasis component is RADIX SANGUISORBA ethyl acetate extract；Described
Lithospermum euchromum Royle extract is the ethyl acetate extract of lithospermum euchromum Royle；The charred NODUS NELUMBINIS RHIZOMATIS extract is the ethyl acetate of charred NODUS NELUMBINIS RHIZOMATIS
Extract；The sophora flower charcoal processing extract is the ethyl acetate extract of sophora flower charcoal processing, and the potato gelsemium extract is potato gelsemium
Ethanol extract.
Further, the preparation of the potato gelsemium extract is the solid-liquid ratio 2 using 80% ethanol water as solvent:1, in 70
DEG C hot water in water-bath extract 3h, put dark place stand 15h, filtering, rotary evaporation be concentrated into 1.5g/ml, concentrate is filtered through micropore
Diaphragm degerming, then forced air drying is made under the conditions of 500 DEG C again.
Further, the preparation method of the Lignum Xanthoceratis extract is as follows：Shiny-leaved yellowhorn table is washed away and silt with circulating water, it will
Ozone generator is passed through in sterile water cleans shiny-leaved yellowhorn again, after pulp crushing is broken into pulp, adds by pulp volume for 30%
Add deionized water, while adding pectase 2.5%, stands 50 min under the conditions of 33 DEG C after stirring and evenly mixing；By the upper layer after standing
90% ethanol solution, under the conditions of 35 DEG C of water temperature, ultrasonic power 100W, ultrasonic extraction 20min, in 4000rpm/min is added in clear liquid
10 min are centrifuged under revolving speed；After centrifugation gained supernatant liquor is concentrated into half flowing slurry, by slurry with 1：12 volume ratios
It is dissolved in deionized water, it is agitated, shake up, after miillpore filter device degerming, obtain Lignum Xanthoceratis extract.
Further, the extracting method concrete operations of the yunnan pine caterpillar pupa chitin are as follows：
（1）De- albumen and lipid；Pine caterpillar is first packed into gauze bag, is dipped in water and squeezes, then washes, filter, separate egg
Pupa skin, be finally placed in sodium hydroxide solution and heat by the intradermal inclusion of white equal pupas and pupa skin, after abandoning spent lye, is washed to
Property is dried；
（2）Demineralization；Oneself the pupa skin through de- albumen, lipid in step 1 is placed in hydrochloric acid solution and is heated, spent acid is abandoned
After liquid, it is washed to neutrality, dries；
（3）Decoloration washing；With the obtained product of hydrogen peroxide processing step 2, it is washed to neutrality after decoloration, dries and obtains first
Chitin；
（4）Deacetylation；Step 3 products therefrom is placed in sodium hydroxide solution and is heated, spent lye is abandoned, is washed to neutrality,
Obtain yunnan pine caterpillar pupa chitin；
Wherein, the sodium hydroxide solution mass fraction is 8%, soaking time 2h, and soaking temperature is 80 DEG C；Hydrochloric acid solution matter
Amount score 2.5%, soaking time 20h, 30 DEG C of soaking temperature；Hydrogenperoxide steam generator mass fraction 11%, soaking time 2.5h impregnate
80 DEG C of temperature.
A kind of preparation method of the medical adhesive with efficient anti-inflammatory hemostatic function, which is characterized in that include the following steps：
Sterile water is added according to number ratio in cell-activating agent MG-60, allantoin, hydrolyzed wheat protein, stabilizer by step 1
In, 85 DEG C are heated to, stirring and dissolving 180min is cooled to room temperature, obtains water solution A；
Step 2, by a- alpha-cyanoacrylate n-octyl, the different monooctyl ester of a- alpha-cyanoacrylate, polyvinyl acetate according to number ratio in
In compound anti-inflammatory fruit oil ingredient, 70 DEG C of stirring 80min are heated to, are cooled to room temperature, compound anti-inflammatory fruit oil ingredient solution B is obtained；
Above-mentioned water solution A and compound anti-inflammatory fruit oil ingredient solution B are uniformly mixed by step 3, and height is added according to number ratio
Anti-inflammatory component and efficiently hemostasis component are imitated, 4h is stirred；
Step 4 handles step 3 products therefrom through filtration sterilization, dispenses, seals, packing up to having efficient anti-inflammatory hemostasis
The medical adhesive of function.
It is to have the advantages that a series of uniquenesses due to it why a-cyanoacrylate class medical adhesive, which quickly grows, i.e., singly
Component, it is solvent-free, do not need additional catalyst etc., at normal temperature can quick-binding.And bonding range is wide, intensity is high,
Has the characteristics that instantaneous solidification, it is often more important that such medical adhesive has no toxic side effect substantially to organisms such as skins.Chemical structure
Particularity determine its advantageous property in terms of bonding, the molecular structure of a-cyanoacrylate class compound
Alpha -carbon atom attracts the very competent of electronics in CNCH2CCOOR, when chemistry will occur immediately for the anion for touching denier
Reaction.Form have on the basic substance gal4 amino acid chain of organism it is a large amount of be in electronegativity group-NH2 and-COOH, when connecing
Contacting can react rapidly when a-cyanoacrylate, and the principle is but also medical adhesive is widely used in clinic.Alpha-cyano third
The type and size of influence and alkyl of the olefin(e) acid ester for tissue have much relations.Ester group carbochain is longer under normal circumstances, polymerization
Reaction rate is slower, reduces to the irritation of tissue, glue-line flexibility improves.The present invention select a- alpha-cyanoacrylate n-octyl and
The different monooctyl ester of a- alpha-cyanoacrylate itself has good biocompatibility and excellent efficient as the primary raw material in system
Anti-inflammatory anthemorrhagic performance.Needle seam operation is substituted, is left no trace after so that skin incision is coincide.Polyvinyl acetate（polyvinyl
acetate）Also known as polyvinyl acetate.It is vinyl acetate（Vinylacetate）Polymer.English abbreviation is PVAc.Letter
Claim PVAc, the polymer of the aggregated generation of vinylacetate.Itself it is exactly excellent adhesive, is added to alpha-cyanoacrylate
It can effectively improve the various comprehensive performances of adhesive in esters matrix.
Chitin is found so far in a kind of storage natural resources extremely abundant and nature on the earth
Unique positively charged tunicin.Due to having unsaturated cation group in its molecular structure, thus it is negative to band
All kinds of harmful substances of charge have powerful suction-operated.It is same it also to remove people intracorporal " rubbish ", reach prevention disease
Disease, the purpose promoted longevity.Due to chitin have this unique function, it by european and American scientists be described as with protein, fat,
Carbohydrate, vitamin, minerals the 6th vital principle of human body of equal importance.Chitin also known as chitin, chitin, chitin,
A kind of biopolymer of chitin, is widely present in the shell of invertebrate and the mycelia of fungi
In body and protozoan and certain green algas.There is chitin anticancer to inhibit cancer, oncocyte transfer, improves the immunity of the human body and protects
Liver detoxification, play the role of it is good control germs/bacteria/mould, while chitin anti-inflammatory and can promote the surface of a wound to be cured
It closes.Dissolved chitosan is in gel state, has stronger adsorption capacity, because containing hydroxyl, amino in chitin molecule
Isopolarity group, hygroscopicity is very strong, is also good moisturizer after skin repair.Pine moth is the forest evil of China's history
Worm, yunnan pine caterpillar are that most tight one of 6 big pine moths are endangered in the whole nation.It is found in the research of pine moth recycling, pinus yunnanensis
In caterpillar pupa and adult in addition to protein rich in and fat, the content of chitin is also higher.
Blood clotting is a series of enzymatic processes, so that fibrinogen is become fibrin, blood is by collosol state
Switch to gel state, fibrin ferment also played an important role in blood coagulation.Blood platelet plays in Blood Coagulation Process focuses on
It acts on, necessary to it sticks, assembles, discharging and play the role of than blood, while it is also provided for the activation of various factors
Membrane phospholipid.Mainly have Anthraquinones in the chemical component of lithospermum euchromum Royle, phenolic acid class, alkaloids, phenol and benzoquinones, triterpenes and
The substances such as sterols, flavonoids and polysaccharide.Lithospermum euchromum Royle ethyl acetate extract has efficient anastalsis, this to stop
Blood effect is to promote fibrinogen to be changed into fibrinous process by increasing fibrinogen content.Increased platelets counts
Quantity influences anticoagulant and fibrinolytic system and works, and on external source and the intrinsic coagulation factor without influence.
RADIX SANGUISORBA (Ceruuium .strictipe.s R. Knuth) MangNiu Er seedling section heroubill platymiscium RADIX SANGUISORBA,
It is used as medicine with root, civil to be also known as cynanchum wilfordii, the area such as Zhong Dian, water are peaceful, water wins in Yunnan, people's reason is widely distributed.For a long time in cloud
The ground such as Bai nationality, the Yi nationality, distributed over Yunnan, Sichuan and Guizhou in south are for treating the diseases such as enteritis.The study found that RADIX SANGUISORBA ethanol extract is in vitro to common enteron aisle
Infectious bacteria has significant antibacterial action, while RADIX SANGUISORBA is anti-inflammatory, and hemostasis, hemoglutination are very strong, and high dose RADIX SANGUISORBA mentions
Object haemostatic effect is taken to be better than Yunnan from medicine.It is anti-inflammatory and quick-acting haemostatic powder blood coagulation that the present invention selects RADIX SANGUISORBA extract to have both simultaneously
Effect.
Rhizoma nelumbinis is the dry root stem of nymphaeaceae plant lotus.First recorded in《This warp》, it is classified as top grade.The stir-fry of charred NODUS NELUMBINIS RHIZOMATIS system rhizoma nelumbinis
Charcoal product are recorded in example version《Chinese Pharmacopoeia》One and《National Chinese medicine preparation specification》.Have the function of hemostasis, dissipate the stasis of blood.Charred NODUS NELUMBINIS RHIZOMATIS
For the rhizome section portion of nymphaeaceae plant lotus.Autumn, two season of winter excavation rhizome (lotus root), section portion is cut, clean, dry, removes fibrous root.Lotus root
Save cylindrical, 2 to 4 centimetres, about 2 centimetres of diameter of length.Surface lark or taupe brown, section portion is expanded, and has most fibrous roots or root
There is crackle in trace, both ends residual face, and body is light and matter is hard, is not easily broken, and there is biggish circular hole 7 to 9 in cross section, differ in size, gas
Nothing, it is sweet in flavor, it is puckery.The sweet adstringency of charred NODUS NELUMBINIS RHIZOMATIS extract is flat, can astringing to arrest bleeding, and can scattered blood stasis, have the characteristics that stop blooding and do not stay the stasis of blood.
Potato gelsemium is distributed in the ground such as the Guangdong, Hunan, Guangxi of China's Mainland, is grown on 400 meters to 750 meters of height above sea level of area,
It is often born in hillside shrubbery or sparse woods, at present not yet by artificial introducing and planting.The reddish brown chief of alias, potato is good, chicken blood lotus, hematogen, cinnabar
Seven, Girald Pteroxygonum Root, Jin Huaguo, herba begoniae laciniatae, my child's blood, ox blood lotus, potato of dying cloth.The ethanol extract of potato gelsemium has good hemostasis and coagulates
The effect of blood, the main component in potato gelsemium extract are tannin and glucoside.Make after wound protein coagulating in exudate, forms knot
Scab film, cause reduce secretion and prevent from infecting, and can make wound and capilary shrink, have local hemostasis effect, wound can be used for outside,
Thus have the characteristics that rapidly and efficiently.In potato gelsemium extract other than above two substance class also containing alkaloids, terpene, steroid
Alcohol, phenols, flavonoids, quinones, thus the hemostasis efficiency that comprehensive function improves.
The major function of blood platelet is blood coagulation and hemostasis, repairs damaged blood vessel.When personal injury bleeds, blood platelet by
There is the aggregation of blood platelet to damage location activation factor stimulation, becomes platelet plug, play the role of primary hemostatic, blood platelet
With other blood coagulation substance calcium ions and fibrin ferment etc. in blood, assemble on damaged vascular wall agglomerating, forms thrombus, blocking
Damaged wound and blood vessel, blood platelet can also discharge adrenaline, cause vessel retraction, promote hemostasis.The ethyl alcohol of potato gelsemium extracts
Object can effectively improve the quantity of blood platelet, ask when so as to shorten bleeding and the clotting time.Exactly because the mechanism, sufficiently demonstrates
The ethanol extract of potato gelsemium has good haemostatic effect.
Sophora flower has cooling blood and hemostasis, and the effect of clearing liver-fire is the common hemostatic of Chinese medicine.Frying charcoal is the common big gun of Chinese medicine
One of method processed.Main component in sophora flower charcoal processing extract is rutin and tanning, Chinese scholartree saponin(e and Isorhamnetin -3-O- rue
It is the main component for playing anastalsis to sugar, can be obviously shortened the bleeding time.
Biologically active peptide is that have positive influence to body function or situation and may finally influence the specific of human health
Protein fragments；Its expection is provided by safe and reliable and consistent oral delivery system.The help of stomach proteolytic enzyme is digesting
Release peptide later, and these absorbed component Parts are physiologically active for people.Biologically active peptide is to anti-inflammatory, anti-
Have the effect of in terms of hypertension, anti-oxidant, anticancer, antibacterial and Antiarthritic excellent.Marine organisms possess with many nutrition
The various biologically active native components of physiological function relevant with pharmaceutical activity, the physiological function are for example anti-oxidant, anti-inflammatory, anti-
Cancer, antibacterial, anti-hypertension, anticoagulant, anti-cardiovascular disease etc..Abalone is ocean gastropod, they are Asia, Africa, Australia
One of important fishery and food industries resource with maricultures a large amount of in America.Abalone fresh goods edible part protein 24%, rouge
Fat 0.44%；Dry product is containing protein 40%, glycogen 33.7%, fat 0.9% and multivitamin and microelement, a kind of couple of people of foot
The very favorable high protein of body, low fat food.Protein rich in, amino acid and flat to body soda acid is adjusted in abalone
Weigh, maintain that nervimuscular excited aspect plays a significant role such as calcium（Ca）, iron（Fe）, zinc（Zn）, selenium（Se）, magnesium（Mg）Deng
Mineral matter element.Research shows that abalone high protein, low fat, amino acid classes are complete, proportion is reasonable, vitamin rich in
E and microelement, while such as EPA, DHA, taurine and superoxide dismutase physiological activator contain in abalone meat
Amount is also compared with horn of plenty.Peng Wenduo's etc. studies have shown that containing whole essential amino acids in Haliotis diversicolor, active material taurine contains
Amount almost maintains an equal level with free amino acid total amount, " kindling material of life " selenium（Se）Content it is very high, and each family vitamin contains
Equal very abundant is measured, phospholipid concentration is also higher.The abalone anti-inflammatory peptides extracted from abalone have higher anti-inflammatory activity, while with
Has most of nutriment in abalone, and healing anti-inflammatory for the hemostasis of post-operative wound is suffered from and be cannot be neglected
Important function.
Radix scrophulariae is Scrophulariaceae herbaceos perennial, has cool blood enriching yin, the function of purging fire for removing toxin.Radix scrophulariae main component is
Polysaccharide, alkaloid.Radix scrophulariae medicinal history is long, has the influence to cardiovascular system, and coronary artery dilator increases cardiac muscle
Nutrient flow amount is reduced blood pressure by expanding blood vessel, platelet aggregation-against, anti-inflammatory anti-oxidant, antibacterial, strengthen immunity etc. are made
With.
Shiny-leaved yellowhorn (Xanthocerassorbifolia Bunge) also known as pawpaw, Wendeng City pavilion, precipice pawpaw etc., belong to no trouble
Scarabaeidae, shiny-leaved yellowhorn category, drying stem branch are known as wood of shiny-leaved yellowhorn.China's traditional medicine thinks, the limb of shiny-leaved yellowhorn, blade, pericarp, flower
The positions such as device are all important medicinal materials, can be extracted with anti-inflammatory, improvement memory, prevention and cure of cardiovascular disease.The activity of shiny-leaved yellowhorn
Ingredient is classified largely into three categories at present：One kind is triterpene compound, and parent nucleus is mostly based on Triterpenoids sapogenins, packet
Include oleanolic acid and a series of saponins compounds；One kind is mainly flavonoids, refers to the classes such as the pure and mild flavane of flavonols, flavanone
Type, including Myricitrin, Quercetin, double hydrogen Myricitrins, epicatechin etc.；Another kind of is cumarin and sterol, including
Fraxin, aesculetin and xanthocerin etc..Xanthocerin therein is able to suppress the exudation and oedema of inflammation early stage, in inflammation
Phase leukocyte chemotaxis and migration inhibit the granulomatous formation of inflammation advanced stage, there is fabulous antiphlogistic effects.
It is also fewer containing other fruit except Kiwi berry vitamin C rich in, A, E and potassium, magnesium, cellulose
Nutritional ingredient-folic acid, carrotene, calcium, lutern, the amino acid, natural inositol seen.Vitamin C can strengthening immune system, promote
Into wound healing and to the absorption of irony；Inositol and amino acid can mend consumed nutrition；The perfect ratio of its low-sodium and high-potassium
Example can mend and bear the physical strength that the sufferer of operation is lost.Folic acid（folic acid）One of vitamin B complex is equivalent to butterfly
Acyl glutamic acid（Pteroylglutamic acid, PGA）, it is Michele（H.K.Mitchell, 1941）It is extracted from the leaf of spinach
Purifying, so it is named as folic acid.There is promoting juvenile cell in marrow mature, the mankind's such as shortage folic acid can cause huge red thin
Born of the same parents' property anaemia and leukopenia.Folic acid is necessary material of human body when using sugar and amino acid, is body cell
Substance necessary to growth and breeding.Folic acid is worked in the form of tetrahydrofolic acid in vivo, and tetrahydrofolic acid participates in fast in vivo
The synthesis and conversion of purine nucleic acid and pyrimidine nucleotide.Folic acid is in manufacture nucleic acid（Ribonucleic acid, DNA）On play the part of weight
The role wanted.Folic acid helps the metabolism of protein, and the generation and maturation of red blood cell are collectively promoted with vitamin B12, is manufacture
The indispensable substance of red blood cell.Folic acid is also used as Lactobacillus casei（Lactobacillus casei）And other microorganisms
Promote proliferation factor and works.Therefore Kiwi extract can more effectively help and promote the healing and high speed of wound
It repairs, and linolenic content is up to 67.34% in Chinese gooseberry seed oil.
Oil and fat of sacha inchi is to squeeze pale yellow transparent oily liquid obtained using the seed of euphorbia plant plukenetia volubilis linneo as raw material
Body.Plukenetia volubilis linneo original is grown in South America Andes area tropical rain forest of height above sea level 80-1700m, in Peru, Ecuador
Deng area, oneself by local original inhabitant has eaten more than one thousand years, introduces a fine variety to China within 2006.Oil and fat of sacha inchi is rich in unsaturated fatty acid, rouge
Soluble vitamin, microelement etc. have the effects of auxiliary reducing blood lipid, anti-oxidant, anti-inflammatory.Oil and fat of sacha inchi contains inhibition inflammatory cell
The factor has extremely good antiphlogistic effects.
Cortex Eucommiae（Scientific name Eucommiaulmoides Oliver）Also known as bakelite, it is Eucommiaceae plant.Cortex Eucommiae free amino acid
Seldom, a small amount of protein contained, be with adequate proteins as most foodstuffs, can hydrolyze detection to needed by human
8 kinds of amino acid.Determine 15 kinds of mineral elements contained by Cortex Eucommiae, wherein have the microelements such as zinc, copper, iron and calcium, phosphorus, potassium,
The macroelements such as magnesium.Linolenic content is up to 62.95% in eucommia ulmoides seed oil.
Schisandra chinensis（Scientific name：Schisandrachinensis （Turcz.）Baill）For magnoliaceae schisandra or China
The dry mature fruit of middle Schisandra chinensis SchisandrasphenantheraRehd. et Wils..The former practises title " Chinese Magnoliavine
Son ", the latter, which practises, claims " kadsura longepedunculata ".It picks, dry or is dried after steaming when the fruit matures in the fall, remove carpopodium and impurity.Tang etc.
《Tang materia medica》" five tastes skin and flesh sweet acid works hard in core, there is saline taste " is carried, therefore has the name of Schisandra chinensis.Schisandra chinensis is divided into south, north two
Kind.Ancient medical book Cheng Ta Chinese magnoliavine, Chinese magnoliavine, meeting and, be listed in Sheng Nong's herbal classic top grade Chinese medicine earliest, can strengthening by means of tonics power, medicinal valence
Be worth it is high, the benefits of keeping fit and healthy.Its fruit contains schizandrin（Schisandrin C23H3206）And vitamin C, resin, tan
Matter and a small amount of carbohydrate.Have and astringes the lung to stop cough, nourishes the benefits of arresting seminal emission, antidiarrheal hidroschesis.Its leaf, fruit can extract aromatic oil, and kernel contains
Fat oil.Wherein, the linoleic acid content in Schisandra chinensis oilseeds oil can be up to 93.30%.
Chinese gooseberry seed oil, Schisandra chinensis seed oil, oil and fat of sacha inchi and eucommia ulmoides seed oil contain a large amount of polyenoic acid, and polyenoic acid is planted
Object oil has fabulous auxiliary lipid-lowering function, anti-oxidation function, anti-senescence function and anti-inflammatory properties.Wherein about anti-inflammatory function
Can, Ω -3 polyenoic acid can by with arachidonic acid compete be metabolized, participate in the recession and tissue repair of inflammation, influence nucleus because
Sub- approach changes the mechanism such as Lipid Rafts approach and has the function that anti-inflammatory.Linoleic acid and methyl linoleate can reduce inflammation it is related because
Sub- interleukins, tumor necrosis factor and nitric oxide level improve significantly to Acute and chronic inflammation.Therefore
Compound anti-inflammatory fruit oil ingredient of the invention combines the extremely high fruit oil ingredient of four kinds of polyenoid acid contents, and it is anti-inflammatory to give full play to its
Effect, while can use other nutritional ingredients in fruit oil again and providing sufficient nutrient for healing skin, add while anti-inflammatory
Speed healing and the reparation of the surface of a wound.
Cell-activating agent MG-60 is that mycoside adds water-starch decomposition product mixed solution, and major function is that cell-activating is made
With；The protective effect for avoiding cell dry；Since ultraviolet light irradiating cell will be damaged, by adding MG-60, it is damaged journey
Degree is mitigated；MG-60 inhibits the generation of one of inflammatory cytokines TNF-a, has good anti-inflammatory effect.
Wheat is as a kind of important agricultural product, and main plantation is in China Middle-north Area, and for a long time, wheat is chiefly used in
And powder produces.Protein is the second largest component in wheat flour, hydrolyzed wheat protein：The primary amino acid gliadin of wheat
(gl5ad55) and the albumen of Mai Gu, cystine (cyst55e) rich in is a kind of sulfur-containing amino acid.It has moisturizing, resists
Oxidation and soft refinement skin, have special moisturizing ingredient, can effectively improve skin condition.Meanwhile hydrolyzed wheat egg
It is white to provide essential amino acid for body anabolism, to maintain internal nitrogen budgets.Especially especially suitable for anti-inflammatory and outer
The postoperative Protein intake of section.That is, hydrolyzed wheat protein can play supplement nutrient protein simultaneously, skin is helped to repair
Multiple and anti-inflammatory effect.
Allantoin, alias Allantoin, Allantoin, Allantion, Allantoin are a kind of second
Interior ureide derivative.About 50,000 tons of annual production capacity of allantoin in the world at present, market be mainly medicine, cosmetics and
Agriculture three big fields, the content that natural allantoin is extracted from natural animal-plant due to traditional handicraft is very low, complex process, cost
It is too high, it can not use on a large scale.In terms of medicine, allantoin, which has, promotes cell growth, accelerates wound healing, cutin-softening egg
The physiological functions such as white are the good consolidant and antiulcer agents of skin trauma.In addition, allantoin can be used as alleviating and treating skin
Skin xerosis, skin ulcer have good therapeutic effect simultaneously for inflammation.Since allantoin is a kind of amphoteric compound, can combine more
Kind of substance forms double salt, have be protected from light, sterilization and anticorrosion, analgesic, antioxidation, skin can be made to keep moisture content, more moisten and
It is soft.
Native cellulose is that the polysaccharide most wide, content is most, source very abundant are distributed in nature.Current fibre element
Modification technology is concentrated mainly on two aspect of etherificate and esterification.Carboxymethylation reaction is one kind of etherification technology.Cellulose is through carboxylic first
Carboxymethyl cellulose is obtained after base（CMC）, aqueous solution is with works such as thickening, the protections of film forming, gluing, water tariff collection, colloid
With.The high-end substitute products of carboxymethyl cellulose (CMC) are that polyanion cellulose (PAC) is also a kind of anionic cellulose
Ether has higher degree of substitution and replaces the uniformity, and strand is shorter, and molecular structure is more stable, therefore has preferably comprehensive
Performance is closed, dissolubility also enhances.Applied to the applicable all industries of carboxymethyl cellulose, it is possible to provide better stability and
Meet higher technique requirement.2,6- di-tert-butyl-4-methy phenols, it is popular for, be that polymer material can be prevented because of oxygen
Change causes rotten substance, is a kind of stabilizer for being effectively used for medical supplies.Polyanion cellulose (PAC) and 2,6- bis-
Being used in combination for both substances of tert-butyl-4-methyl-Phenol effectively can provide better stability for reaction system, mention
The comprehensive performances such as high-wearing feature, while the bond properties of medical adhesive can be enhanced and there is moisture retaining quality.
Due to using above technical scheme, the present invention is had the advantages that：
1, the efficient anti-inflammatory component that the efficiently anti-inflammatory hemostasis component of the present invention is selected includes abalone anti-inflammatory peptides, yunnan pine caterpillar pupa first
Shell element, radix scrophulariae polysaccharide, Lignum Xanthoceratis extract have effects that the component of completely different anti-inflammatory principle sum constitutes the using four kinds
One efficient anti-inflammatory system.Wherein, the abalone anti-inflammatory peptides of Ocean Living anti-inflammatory activity are sufficiently combined, anti-inflammatory and can promote to create
The yunnan pine caterpillar pupa chitin of the efficiency natural of face healing, platelet aggregation-against, anti-inflammatory oxidation resistant medicinal history are with regard to long
Radix scrophulariae polysaccharide and the exudation and oedema of inflammation early stage are able to suppress containing xanthocerin, inflammation mid-term leukocyte chemotaxis and trip
It walks, inhibits the granulomatous formation of inflammation advanced stage, there is the Lignum Xanthoceratis extract of fabulous antiphlogistic effects, four kinds of main anti-inflammatory components
Product of the present invention efficiently anti-inflammatory performance has just been established in collaboration mutual assistance.The composite fruit oil formed in conjunction with compound anti-inflammatory fruit oil ingredient
Anti-inflammatory system.Two big anti-inflammatory system effective components complement each other, shortening bleeding time and blood coagulation along with efficient hemostasis component
The quick-acting haemostatic powder effect of time mutually cooperates with the purpose for effectively realizing efficiently anti-inflammatory hemostasis of the invention.
2, lithospermum euchromum Royle ethyl acetate extract of the present invention has efficient anastalsis, and this anastalsis is to pass through
Increase fibrinogen content, fibrinogen is promoted to be changed into fibrinous process.Increased platelets counts quantity influences anticoagulant
It works with fibrinolytic system, and on external source and the intrinsic coagulation factor without influence.The ethanol extract of potato gelsemium can effectively improve blood
The quantity of platelet, is asked and the clotting time when so as to shorten bleeding.Chinese scholartree saponin(e and Isorhamnetin -3-O- rutinose its be to play
The main component of anastalsis can be obviously shortened the bleeding time.The sweet adstringency of charred NODUS NELUMBINIS RHIZOMATIS extract is flat, can astringing to arrest bleeding, and energy
Scattered blood stasis has the characteristics that the stasis of blood is not stayed in hemostasis.
RADIX SANGUISORBA it is anti-inflammatory, hemostasis, hemoglutination it is very strong, high dose RADIX SANGUISORBA extract haemostatic effect better than Yunnan from
Medicine, the present invention select RADIX SANGUISORBA extract to have both anti-inflammatory and quick-acting haemostatic powder blood coagulation effect simultaneously.The present invention sufficiently combines
The different hemostasis special efficacys of five kinds of substances, construct haemostatic system rapidly and efficiently in component of efficiently stopping blooding, big to combination two
Anti-inflammatory system realizes the purpose of efficient anti-inflammatory hemostasis jointly.
3, the present invention has the compound anti-inflammatory fruit oil that the medical adhesive of efficient anti-inflammatory hemostatic function is selected, by Chinese gooseberry seed oil,
Schisandra chinensis seed oil, oil and fat of sacha inchi and eucommia ulmoides seed oil collaboration use, one be made up of four kinds of fruit oil with anti-inflammatory efficacy
The basic and powerful anti-inflammatory system of fruit oil.Chinese gooseberry seed oil, Schisandra chinensis seed oil, oil and fat of sacha inchi and eucommia ulmoides seed oil contain largely
Polyenoic acid, polyenoic acid vegetable oil have fabulous auxiliary lipid-lowering function, anti-oxidation function, anti-senescence function and anti-inflammatory function
Energy.Wherein about anti-inflammatory properties, Ω -3 polyenoic acid can be metabolized by competing with arachidonic acid, participate in the recession and tissue of inflammation
It repairs, influences nuclear factor approach, change the mechanism such as Lipid Rafts approach and have the function that anti-inflammatory.Linoleic acid and methyl linoleate
Inflammation-related factor interleukins, tumor necrosis factor and nitric oxide level can be reduced, is had to Acute and chronic inflammation obvious
Improvement result.Therefore compound anti-inflammatory fruit oil ingredient of the invention combines the extremely high fruit oil ingredient of four kinds of polyenoid acid contents,
Its anti-inflammatory effect is given full play to, while can use other nutritional ingredients in fruit oil again and providing sufficient support for healing skin
Point, the reparation of healing acceleration and surface of a wound while anti-inflammatory.
4, there is the present invention medical adhesive of efficient anti-inflammatory hemostatic function to be especially added with allantoin, have its it is unique and
Important role.Allantoin, which has, promotes cell growth, accelerates wound healing, the physiological functions such as cutin-softening albumen, are skin
The good consolidant of wound.In addition, allantoin can be used as alleviating and treat xerodermia, skin ulcer, simultaneously for inflammation
There is good therapeutic effect.Since allantoin is a kind of amphoteric compound, double salt can be formed in conjunction with many kinds of substance, have and be protected from light, sterilize and prevent
Rotten, analgesic, antioxidation can make skin keep moisture content, more moisten and soft.The use of allantoin, also corresponds to simultaneously
Formaldehyde inhibitor is acted as in system, effectively plays the role of formaldehyde inhibitor, therefore this system is single without additional addition
Only formaldehyde inhibitor and preservative.
5, the present invention has each addition other than stabilizer that the medical adhesive of efficient anti-inflammatory hemostatic function is selected
Ingredient, which all has certain anti-inflammatory hemostatic function, including cell-activating agent MG-60, hydrolyzed wheat protein, allantoin etc., to be become
The effect of entire efficiently anti-inflammatory essential component part of hemostasia products, a variety of efficiently anti-inflammatory hemostasis components completely day
At the medical adhesive that the present invention has efficient anti-inflammatory hemostatic function is prepared.
There is the present invention adhesion strength of the medical adhesive of efficient anti-inflammatory hemostatic function to be all larger than 60N, when to the hemostasis of wound
Between be lower than 110 seconds, whole cure rate is higher, and biocompatibility is high, non-stimulated to wound tissue, reduces sensitization rate, comprehensive performance
It is outstanding, meet the clinical application requirement to adhesive of medical, it is maximum by the efficient anti-inflammatory anthemorrhagic performance for improving adhesive of medical
The pain that the needs of the reduction patient of limit are born.
Specific embodiment
The present invention is specifically described below by specific embodiment：
Embodiment 1
A kind of medical adhesive with efficient anti-inflammatory hemostatic function, the component including following parts by weight：A- alpha-cyanoacrylate is just pungent
25 parts of the different monooctyl ester of 20 parts of ester, a- alpha-cyanoacrylate, 2 parts of polyvinyl acetate, efficiently 12 parts of anti-inflammatory component, efficiently hemostasis component 13
Part, 3 parts of cell-activating agent MG-60,8 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizer, compound anti-inflammatory fruit oil ingredient
150 parts, 200 parts of sterile water；Efficient anti-inflammatory component is calculated according to weight fraction, including 2 parts of abalone anti-inflammatory peptides, yunnan pine caterpillar pupa
3 parts of chitin, 6 parts of radix scrophulariae polysaccharide, 5 parts of Lignum Xanthoceratis extract；Efficiently hemostasis component is calculated according to weight fraction, including RADIX SANGUISORBA
5 parts of extract, 3 parts of lithospermum euchromum Royle extract, 3 parts of potato gelsemium extract, charred NODUS NELUMBINIS RHIZOMATIS extract 6,6 parts of sophora flower charcoal processing extract；It is multiple
Anti-inflammatory fruit oil ingredient is closed, is calculated according to weight fraction, including 4 parts of Chinese gooseberry seed oil, 3 parts of oil and fat of sacha inchi, 2 parts of eucommia ulmoides seed oil and five
5 parts of taste seed oil.Stabilizer is by polyanion cellulose and 2,6 di tert butyl 4 methyl phenol according to parts by weight 10：1 group
It closes.Efficiently the RADIX SANGUISORBA extract in hemostasis component is RADIX SANGUISORBA ethyl acetate extract；Lithospermum euchromum Royle extract is new
The ethyl acetate extract of boundary Asian puccoon；Charred NODUS NELUMBINIS RHIZOMATIS extract is the ethyl acetate extract of charred NODUS NELUMBINIS RHIZOMATIS；Sophora flower charcoal processing extract is
The ethyl acetate extract of sophora flower charcoal processing, potato gelsemium extract are the ethanol extract of potato gelsemium.
Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested
As a result it is：It is 61N that the present invention, which has the adhesion strength of the medical adhesive of efficient anti-inflammatory hemostatic function, and the bleeding stopping period to wound is
109 seconds, whole cure rate was higher.
Embodiment 2
A kind of medical adhesive with efficient anti-inflammatory hemostatic function, the component including following parts by weight：A- alpha-cyanoacrylate is just pungent
28 parts of the different monooctyl ester of 22 parts of ester, a- alpha-cyanoacrylate, 4 parts of polyvinyl acetate, efficiently 16 parts of anti-inflammatory component, efficiently hemostasis component 18
Part, 4 parts of cell-activating agent MG-60,9 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizer, compound anti-inflammatory fruit oil ingredient
180 parts, 200 parts of sterile water；Efficient anti-inflammatory component is calculated according to weight fraction, including 2 parts of abalone anti-inflammatory peptides, yunnan pine caterpillar pupa
3 parts of chitin, 6 parts of radix scrophulariae polysaccharide, 5 parts of Lignum Xanthoceratis extract；Efficiently hemostasis component is calculated according to weight fraction, including RADIX SANGUISORBA
5 parts of extract, 3 parts of lithospermum euchromum Royle extract, 3 parts of potato gelsemium extract, charred NODUS NELUMBINIS RHIZOMATIS extract 6,6 parts of sophora flower charcoal processing extract；It is multiple
Anti-inflammatory fruit oil ingredient is closed, is calculated according to weight fraction, including 4 parts of Chinese gooseberry seed oil, 3 parts of oil and fat of sacha inchi, 2 parts of eucommia ulmoides seed oil and five
5 parts of taste seed oil.Stabilizer is by polyanion cellulose and 2,6 di tert butyl 4 methyl phenol according to parts by weight 10：1 group
It closes.Efficiently the RADIX SANGUISORBA extract in hemostasis component is RADIX SANGUISORBA ethyl acetate extract；Lithospermum euchromum Royle extract is new
The ethyl acetate extract of boundary Asian puccoon；Charred NODUS NELUMBINIS RHIZOMATIS extract is the ethyl acetate extract of charred NODUS NELUMBINIS RHIZOMATIS；Sophora flower charcoal processing extract is
The ethyl acetate extract of sophora flower charcoal processing, potato gelsemium extract are the ethanol extract of potato gelsemium.
Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested
As a result it is：It is 62N that the present invention, which has the adhesion strength of the medical adhesive of efficient anti-inflammatory hemostatic function, and the bleeding stopping period to wound is
106 seconds, whole cure rate was higher.
Embodiment 3
A kind of medical adhesive with efficient anti-inflammatory hemostatic function, the component including following parts by weight：A- alpha-cyanoacrylate is just pungent
32 parts of the different monooctyl ester of 24 parts of ester, a- alpha-cyanoacrylate, 5 parts of polyvinyl acetate, efficiently 18 parts of anti-inflammatory component, efficiently hemostasis component 20
Part, 5 parts of cell-activating agent MG-60,10 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizer, compound anti-inflammatory fruit oil ingredient
200 parts, 200 parts of sterile water；Efficient anti-inflammatory component is calculated according to weight fraction, including 2 parts of abalone anti-inflammatory peptides, yunnan pine caterpillar pupa
3 parts of chitin, 6 parts of radix scrophulariae polysaccharide, 5 parts of Lignum Xanthoceratis extract；Efficiently hemostasis component is calculated according to weight fraction, including RADIX SANGUISORBA
5 parts of extract, 3 parts of lithospermum euchromum Royle extract, 3 parts of potato gelsemium extract, charred NODUS NELUMBINIS RHIZOMATIS extract 6,6 parts of sophora flower charcoal processing extract；It is multiple
Anti-inflammatory fruit oil ingredient is closed, is calculated according to weight fraction, including 4 parts of Chinese gooseberry seed oil, 3 parts of oil and fat of sacha inchi, 2 parts of eucommia ulmoides seed oil and five
5 parts of taste seed oil.Stabilizer is by polyanion cellulose and 2,6 di tert butyl 4 methyl phenol according to parts by weight 10：1 group
It closes.Efficiently the RADIX SANGUISORBA extract in hemostasis component is RADIX SANGUISORBA ethyl acetate extract；Lithospermum euchromum Royle extract is new
The ethyl acetate extract of boundary Asian puccoon；Charred NODUS NELUMBINIS RHIZOMATIS extract is the ethyl acetate extract of charred NODUS NELUMBINIS RHIZOMATIS；Sophora flower charcoal processing extract is
The ethyl acetate extract of sophora flower charcoal processing, potato gelsemium extract are the ethanol extract of potato gelsemium.
Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested
As a result it is：It is 61.5N that the present invention, which has the adhesion strength of the medical adhesive of efficient anti-inflammatory hemostatic function, and the bleeding stopping period to wound is
107 seconds, whole cure rate was higher.
Embodiment 4
A kind of medical adhesive with efficient anti-inflammatory hemostatic function, the component including following parts by weight：A- alpha-cyanoacrylate is just pungent
35 parts of the different monooctyl ester of 25 parts of ester, a- alpha-cyanoacrylate, 6 parts of polyvinyl acetate, efficiently 20 parts of anti-inflammatory component, efficiently hemostasis component 23
Part, 6 parts of cell-activating agent MG-60,10 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizer, compound anti-inflammatory fruit oil ingredient
220 parts, 200 parts of sterile water；Efficient anti-inflammatory component is calculated according to weight fraction, including 2 parts of abalone anti-inflammatory peptides, yunnan pine caterpillar pupa
3 parts of chitin, 6 parts of radix scrophulariae polysaccharide, 5 parts of Lignum Xanthoceratis extract；Efficiently hemostasis component is calculated according to weight fraction, including RADIX SANGUISORBA
5 parts of extract, 3 parts of lithospermum euchromum Royle extract, 3 parts of potato gelsemium extract, charred NODUS NELUMBINIS RHIZOMATIS extract 6,6 parts of sophora flower charcoal processing extract；It is multiple
Anti-inflammatory fruit oil ingredient is closed, is calculated according to weight fraction, including 4 parts of Chinese gooseberry seed oil, 3 parts of oil and fat of sacha inchi, 2 parts of eucommia ulmoides seed oil and five
5 parts of taste seed oil.Stabilizer is by polyanion cellulose and 2,6 di tert butyl 4 methyl phenol according to parts by weight 10：1 group
It closes.Efficiently the RADIX SANGUISORBA extract in hemostasis component is RADIX SANGUISORBA ethyl acetate extract；Lithospermum euchromum Royle extract is new
The ethyl acetate extract of boundary Asian puccoon；Charred NODUS NELUMBINIS RHIZOMATIS extract is the ethyl acetate extract of charred NODUS NELUMBINIS RHIZOMATIS；Sophora flower charcoal processing extract is
The ethyl acetate extract of sophora flower charcoal processing, potato gelsemium extract are the ethanol extract of potato gelsemium.
Adhesive of medical is prepared using above-described embodiment to smear wound, and carries out correlated performance test, is tested
As a result it is：It is 62N that the present invention, which has the adhesion strength of the medical adhesive of efficient anti-inflammatory hemostatic function, and the bleeding stopping period to wound is
105 seconds, whole cure rate was higher.
In above-mentioned each embodiment
The preparation method of lithospermum euchromum Royle extract is as follows：
By lithospermum euchromum Royle through drying, beat powder after sieve with 100 mesh sieve, obtain the powder of lithospermum euchromum Royle, it is molten that 95% ethyl alcohol be then added
Liquid, under the conditions of 45 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 35min obtains extracting solution；Extracting solution is filtered and is concentrated under reduced pressure,
Obtain slurry；By slurry with 1：15 volume ratios are dissolved in deionized water, agitated, shake up, after miillpore filter device degerming, are obtained
To lithospermum euchromum Royle extract.
The preparation method of potato gelsemium extract is as follows：
The preparation of potato gelsemium extract is the solid-liquid ratio 2 using 80% ethanol water as solvent:1, the water-bath in 70 DEG C of hot water
3h is extracted, dark place is put and stands 15h, filtering, rotary evaporation are concentrated into 1.5g/ml, and concentrate is through miillpore filter device degerming, then again
Forced air drying is made under the conditions of 500 DEG C.
The preparation method of Lignum Xanthoceratis extract is as follows：
Shiny-leaved yellowhorn table is washed away and silt with circulating water, and ozone generator is passed through in sterile water and cleans shiny-leaved yellowhorn again, by pulp
Crushing is broken into after pulp, is 30% addition deionized water by pulp volume, while being added pectase 2.5%, after stirring and evenly mixing
50 min are stood under the conditions of 33 DEG C；90% ethanol solution, at 35 DEG C of water temperature, ultrasonic power is added in supernatant liquor after standing
Under the conditions of 100W, ultrasonic extraction 20min is centrifuged 10 min under 4000rpm/min revolving speed；It will centrifugation gained supernatant liquor concentration
To half flowing slurry, by slurry with 1：12 volume ratios are dissolved in deionized water, agitated, shake up, through miillpore filter device
After degerming, Lignum Xanthoceratis extract is obtained.
The extracting method concrete operations of yunnan pine caterpillar pupa chitin are as follows:
（1）De- albumen and lipid；Pine caterpillar is first packed into gauze bag, is dipped in water and squeezes, then washes, filter, separate egg
Pupa skin, be finally placed in sodium hydroxide solution and heat by the intradermal inclusion of white equal pupas and pupa skin, after abandoning spent lye, is washed to
Property is dried；
（2）Demineralization；Oneself the pupa skin through de- albumen, lipid in step 1 is placed in hydrochloric acid solution and is heated, spent acid is abandoned
After liquid, it is washed to neutrality, dries；
（3）Decoloration washing；With the obtained product of hydrogen peroxide processing step 2, it is washed to neutrality after decoloration, dries and obtains first
Chitin；
（4）Deacetylation；Step 3 products therefrom is placed in sodium hydroxide solution and is heated, spent lye is abandoned, is washed to neutrality,
Obtain yunnan pine caterpillar pupa chitin；
Wherein, the sodium hydroxide solution mass fraction is 8%, soaking time 2h, and soaking temperature is 80 DEG C；Hydrochloric acid solution matter
Amount score 2.5%, soaking time 20h, 30 DEG C of soaking temperature；Hydrogenperoxide steam generator mass fraction 11%, soaking time 2.5h impregnate
80 DEG C of temperature.
The preparation method of the above-mentioned medical adhesive with efficient anti-inflammatory hemostatic function, includes the following steps：
Sterile water is added according to number ratio in cell-activating agent MG-60, allantoin, hydrolyzed wheat protein, stabilizer by step 1
In, 85 DEG C are heated to, stirring and dissolving 180min is cooled to room temperature, obtains water solution A；
Step 2, by a- alpha-cyanoacrylate n-octyl, the different monooctyl ester of a- alpha-cyanoacrylate, polyvinyl acetate according to number ratio in
In compound anti-inflammatory fruit oil ingredient, 70 DEG C of stirring 80min are heated to, are cooled to room temperature, compound anti-inflammatory fruit oil ingredient solution B is obtained；
Above-mentioned water solution A and compound anti-inflammatory fruit oil ingredient solution B are uniformly mixed by step 3, and height is added according to number ratio
Anti-inflammatory component and efficiently hemostasis component are imitated, 4h is stirred；
Step 4 handles step 3 products therefrom through filtration sterilization, dispenses, seals, packing up to having efficient anti-inflammatory hemostasis
The medical adhesive of function.
Performance test
It prepares adhesive of medical using above-described embodiment to smear wound, the present invention has the doctor of efficient anti-inflammatory hemostatic function
It is all larger than 60N with the adhesion strength of glue, the bleeding stopping period to wound is lower than 110 seconds, and whole cure rate is higher, biocompatibility
Height, it is non-stimulated to wound tissue, sensitization rate is reduced, comprehensive performance is outstanding, meets the clinical application requirement to adhesive of medical.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (6)
1. a kind of medical adhesive with efficient anti-inflammatory hemostatic function, which is characterized in that the component including following parts by weight：A- cyanogen
20-25 parts of base n-octyl, a- alpha-cyanoacrylate be monooctyl ester 25-35 parts different, 2-6 parts of polyvinyl acetate, efficiently anti-inflammatory group
Divide 12-20 parts, efficiently stop blooding component 13-23 parts, 3-6 parts of cell-activating agent MG-60,8-10 parts of allantoin, hydrolyzed wheat protein
1 part, 1 part of stabilizer, compound 150-220 parts of anti-inflammatory fruit oil ingredient, 200 parts of sterile water；
The efficient anti-inflammatory component is calculated according to weight fraction, including 2 parts of abalone anti-inflammatory peptides, yunnan pine caterpillar pupa chitin 3
Part, 6 parts of radix scrophulariae polysaccharide, 5 parts of Lignum Xanthoceratis extract；
The efficient hemostasis component is calculated according to weight fraction, including 5 parts of RADIX SANGUISORBA extract, 3 parts of lithospermum euchromum Royle extract,
3 parts of potato gelsemium extract, charred NODUS NELUMBINIS RHIZOMATIS extract 6,6 parts of sophora flower charcoal processing extract；
The compound anti-inflammatory fruit oil ingredient, calculates according to weight fraction, including 4 parts of Chinese gooseberry seed oil, 3 parts of oil and fat of sacha inchi, Du
Secondary 2 parts and 5 parts of magnolia vine fruit oil of seed oil.
2. the medical adhesive with efficient anti-inflammatory hemostatic function according to claim 1, which is characterized in that the stabilizer is
By polyanion cellulose and 2,6 di tert butyl 4 methyl phenol according to parts by weight 10：1 is composed.
3. the medical adhesive with efficient anti-inflammatory hemostatic function according to claim 1 or 2, which is characterized in that described efficient
RADIX SANGUISORBA extract in component of stopping blooding is RADIX SANGUISORBA ethyl acetate extract；The lithospermum euchromum Royle extract is lithospermum euchromum Royle
Ethyl acetate extract；The charred NODUS NELUMBINIS RHIZOMATIS extract is the ethyl acetate extract of charred NODUS NELUMBINIS RHIZOMATIS；The sophora flower charcoal processing mentions
Taking object is the ethyl acetate extract of sophora flower charcoal processing, and the potato gelsemium extract is the ethanol extract of potato gelsemium.
4. the medical adhesive with efficient anti-inflammatory hemostatic function according to claim 3, which is characterized in that the potato gelsemium extracts
The preparation of object is the solid-liquid ratio 2 using 80% ethanol water as solvent:1, water-bath extracts 3h in 70 DEG C of hot water, puts dark place
15h is stood, filtering, rotary evaporation are concentrated into 1.5g/ml, and concentrate is through miillpore filter device degerming, then drum under the conditions of 500 DEG C again
Air-dry dry be made.
5. the medical adhesive with efficient anti-inflammatory hemostatic function according to claim 1 or 2 or 4, which is characterized in that described
The preparation method of Lignum Xanthoceratis extract is as follows：Shiny-leaved yellowhorn table is washed away and silt with circulating water, and ozone generator is passed through sterile water
In clean shiny-leaved yellowhorn again, by pulp crushing break into pulp after, by pulp volume be 30% add deionized water, add simultaneously
Pectase 2.5% stands 50 min under the conditions of 33 DEG C after stirring and evenly mixing；It is molten that 90% ethyl alcohol is added in supernatant liquor after standing
Liquid, under the conditions of 35 DEG C of water temperature, ultrasonic power 100W, ultrasonic extraction 20min is centrifuged 10 min under 4000rpm/min revolving speed；
After centrifugation gained supernatant liquor is concentrated into half flowing slurry, by slurry with 1：12 volume ratios are dissolved in deionized water, warp
It stirs, shake up, after miillpore filter device degerming, obtaining Lignum Xanthoceratis extract.
6. the medical adhesive with efficient anti-inflammatory hemostatic function according to claim 5, which is characterized in that the pinus yunnanensis
The extracting method concrete operations of caterpillar pupa chitin are as follows:
（1）De- albumen and lipid；Pine caterpillar is first packed into gauze bag, is dipped in water and squeezes, then washes, filter, separate egg
Pupa skin, be finally placed in sodium hydroxide solution and heat by the intradermal inclusion of white equal pupas and pupa skin, after abandoning spent lye, is washed to
Property is dried；
（2）Demineralization；Oneself the pupa skin through de- albumen, lipid in step 1 is placed in hydrochloric acid solution and is heated, spent acid is abandoned
After liquid, it is washed to neutrality, dries；
（3）Decoloration washing；With the obtained product of hydrogen peroxide processing step 2, it is washed to neutrality after decoloration, dries and obtains first
Chitin；
（4）Deacetylation；Step 3 products therefrom is placed in sodium hydroxide solution and is heated, spent lye is abandoned, is washed to neutrality,
Obtain yunnan pine caterpillar pupa chitin；
Wherein, the sodium hydroxide solution mass fraction is 8%, soaking time 2h, and soaking temperature is 80 DEG C；Hydrochloric acid solution matter
Amount score 2.5%, soaking time 20h, 30 DEG C of soaking temperature；Hydrogenperoxide steam generator mass fraction 11%, soaking time 2.5h impregnate
80 DEG C of temperature.
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