CN106474536A - A kind of liquid bandage for War injury - Google Patents
A kind of liquid bandage for War injury Download PDFInfo
- Publication number
- CN106474536A CN106474536A CN201610906714.8A CN201610906714A CN106474536A CN 106474536 A CN106474536 A CN 106474536A CN 201610906714 A CN201610906714 A CN 201610906714A CN 106474536 A CN106474536 A CN 106474536A
- Authority
- CN
- China
- Prior art keywords
- liquid bandage
- war injury
- injury according
- derivative
- war
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
Abstract
The invention discloses a kind of liquid bandage for War injury, including the acid derivative of matter containing sulfydryl, acrylate derivative, viscosifier, wetting agent, preservative, borate buffer solution and deionized water；Wherein sulfydryl matter acid derivative, viscosifier, wetting agent, preservative, deionized water are component A, and acrylate derivative, borate buffer solution, preservative, deionized water are component B；A and B component are sprayed at wound respectively, within 10 second time, quickly crosslink formation hydrogel application.The liquid bandage for War injury of the present invention has excellent biocompatibility, no skin irritation and cytotoxicity it is adaptable to the War injury such as the less gunshot wound of wound, burn and incised wound.
Description
Technical field
The present invention relates to a kind of liquid bandage for War injury, especially one kind are applied to the less gunshot wound of wound, burning
The liquid bandage of the War injury such as wound and incised wound.
Background technology
Interim in modern war, various types of burns increase, and how to be occurred in the form of combined injury, all have more wound
Face.For scars of war, widely used conventional bandages (gauze) are mainly using cotton yarn as base material, and its major function is wrapping
Wound or hemostasis.This conventional bandages is bound up a wound loaded down with trivial details, and will consume about up to ten thousand tons of cotton yarns every year.As conventional bandages
Deformation-common adhesive bandage is by gauze, rubber adhesive and to be attached to the active drug composition two on rubber adhesive
Part forms.Gauze plays support in effect, and has the function of absorbing wound transudate；Rubber adhesive adheres to skin table
Fixation is played in face；Active drug composition plays antibacterial, antiinflammatory, the function of hemostasis.But limited in one's ability due to absorbing sepage, and should
Class tourniquet bandage (gauze) is also subject to certain impact and restriction due to its mechanical performance that limits of its material, also can shadow during use
Sound is attractive in appearance.The greatest problem that the use of conventional bandages is restricted is in wound healing process, and binder is easy to regenerating tissues and occurs
Adhesion, when recovering from injury removing it is easy to cause secondary damage.
It is desirable to hydrogel is liquid when using in a lot of biological medicine applications, but fast after reaching appointed part
Speed forms gel, loses flowability." liquid bandage " overcomes many drawbacks of traditional wound surface protective material, imparts wound shield
Manage new function：As binder, adhesive bandage etc. to irregular wound face or some human body protective capacities of being inconvenient to use poor,
Water-proof breathable properties are bad, helpless to the bacterium infection of wound, use inaesthetic shortcoming.However, " liquid bandage "
For wound care, there is obviously advantage：Ratio, if the shape fully according to wound forms one layer of hydrogel, sticks
Hydrogel thin film can stop blooding, using being easily removed after terminating etc..Up to the present, research worker has investigated various ways in fact
The quick-gelatinizing of existing hydrogel.For example, the unsaturated derivant of water-soluble polyethylene glycol and derivant pass through photo-initiated crosslinking
Prepare gel；The solution of the triblock copolymer of the Polyethylene Glycol of specific composition and polypropylene glycol has the solidifying of temperature change initiation
Gel behavior；Cyanoacrylate polymerizable is cross-linked to form gel, gluing for organizing；Glutaraldehyde cross-linking material of gelatin etc..
In general, there are various defects in these above-mentioned hydrogels, such as poor biocompatibility, poor biodegradation
Performance etc..Quick-gelatinizing typically requires the cross-linking agent of high activity, and these compounds generally have larger toxic and side effects.
Sulfydryl is the naturally occurring functional group with good biocompatibility in vivo.It has good reaction
Activity, at identical conditions its reactivity generally than amino high several orders of magnitude.The crosslinking of sulfydryl may be selected activity relatively
Low bio-compatible cross-linking agent, prepared hydrogel has more preferable biocompatibility.Wallace etc. multi-arm (four arms or
12 arms) Polyethylene Glycol mercapto derivatives are dissolved in the sodium phosphate/sodium carbonate buffer (pH=9.6) of 0.3mol/L, multi-arm (four
Arm or 12 arms) Polyethylene Glycol butanediol succimide activated derivatives are dissolved in the sodium phosphate buffer of 0.0005mol/L
(pH=6.0), it is prepared for hydrogel by mixing above two solution, in wound care art, there is obvious advantage
(Wallace etc., US6,624,245).
From the point of view of the research, patent or the product that have just disclosed at present, will have antibacterial bacteriostatic, promote the functions such as wound healing
Macromole combined by various modes and make the research of hydrogel moist dressing and compare and receive publicity, and before market
Scape is huge.But although this hydrogel functionally meets, on wound surface formed gel have on earth how soon how good, still not
The requirement of emergency care of trauma can be reached.The Quick cross-linking time of current " liquid bandage " is mostly in a few minutes to a few hours.
And certain limitation is existed on using method.
Content of the invention
The technical problem to be solved is to overcome prior art defect, provides and a kind of has excellent biofacies
Capacitive, no skin irritation and the liquid bandage for War injury of cytotoxicity, energy Quick cross-linking.
In order to solve above-mentioned technical problem, provided by the present invention for the liquid bandage of War injury, spread out including sulfydryl matter acid
Biology, acrylate derivative, viscosifier, wetting agent, preservative, borate buffer solution and deionized water；Wherein sulfydryl matter acid
Derivant, viscosifier, wetting agent, preservative, deionized water are component A, and acrylate derivative, preservative, borate buffer are molten
Liquid, deionized water are component B.
As improvement, described sulfydryl matter acid derivative accounts for gross weight ratio and is：0.5-5%, described acrylate derivative accounts for
Than for 0.5-5%, described viscosifier account for gross weight than for 3-20% to gross weight, and described wetting agent accounts for gross weight than for 5-35%,
Described preservative accounts for gross weight than for 0.05-1%, and described deionized water accounts for gross weight than for 20-60%.
As improvement, described sulfydryl matter acid derivative is one kind of H-1, H-2 or two kinds.
As improvement, described sulfydryl matter acid derivative at least contains three sulfydryls.
As improvement, described acrylate derivative is tetramethyl acrylate derivative.
As improvement, described acrylate derivative be one kind of PEG-2, PEG-4, H-3 or two kinds and more than.
As improvement, described viscosifier are water soluble starch, Polyvinylpyrrolidone, polyvinyl alcohol, gelatin, carboxymethyl are fine
One or more of dimension element, polyvidone, collagen protein, vegetable polysaccharidess.
As improvement, described wetting agent is one of glycerol, propylene glycol, Polyethylene Glycol, glycerol, Sorbitol or many
Kind.
As improvement, described wetting agent is isopropanol.
As improvement, described preservative is parabenses, benzoic acid and its salt, sorbic acid and its salt, Ben Zha
Bromo-amine, one or more of chlorhexidine acetate.
As improvement, described preservative is Nipagin ester, and it accounts for total mass ratio is 0.05%-0.1%.
As improvement, the pH value of described borate buffer solution is 9.5-11.0.
The beneficial effects of the present invention is：The present invention is used for the acid of primary raw material matter containing sulfydryl used by liquid bandage of War injury
The good biocompatibility of derivant, the by-product not producing side reaction and not producing toxic side effect, each component being used is steady
Qualitative energy is good, consumption is few, with low cost, easy to use be easily achieved quick-gelatinizing, be easily achieved quick-gelatinizing spray
Preparation, be suitable for multiple difference medical usage the advantages of；Blending ingredients A and bis- kinds of solution of component B, can occur within 20 seconds
Gelation.The field emergency field of the especially suitable War injury of the present invention.
Brief description
Fig. 1 is sulfydryl matter acid derivative of the present invention and hyaluronic acid1H NMR spectra；
Specific embodiment
Below in conjunction with accompanying drawing, the present invention is elaborated.
Embodiment 1
The preparation of the acid derivative H-1 of matter containing sulfydryl：
10 grams of hyaluronic acids are dissolved in 1L distilled water.It is subsequently added 12 grams of dithio dipropyl two hydrazides, be sufficiently stirred for dissolving.
With 0.1mol/L dilute hydrochloric acid, above solution ph is adjusted to 4.75, add 19.2 grams of 1- ethyl -3- (3- dimethylamine propyl)
Carbodiimide hydrochloride, continuing stirring makes it fully dissolve.Reaction 12 hours, and keep reacting solution pH value 4.75.
With the sodium hydroxide solution of 1.0mol/L, the pH value of solution in 1 is adjusted to 7.0, is subsequently adding 50 grams of dithiothreitol, DTTs,
And adjust pH value of solution for 8.5.After normal-temperature reaction 24 hours, the hydrochloric acid conditioning solution pH using 1mol/L is 3.5.Then by sample
Load in bag filter and dialyse (molecular cut off 3500), dialysed 4-5 days using pure water, change a dialysis solution for every eight hours.Finally
Collect the solution in Dialysis tubing, lyophilization obtains white fluffy solid.Wherein, sulfydryl matter acid derivative and hyaluronic acid1H
NMR spectra is as shown in Figure 1.
Embodiment 2
The preparation of the PEG-2 of polyethyleneglycol derivative containing dimethacrylate：
4g Polyethylene Glycol is added in the dichloromethane of 50mL, adds 1g triethylamine, mixed liquor is cooled to 0 DEG C.Then
The dichloromethane solution of 1g methacrylic chloride is added dropwise in reaction system, reacts continuously stirred 12 hours.By three times two
Chloromethanes dissolving and ether deposition and purification finally give end-product.
Embodiment 3
The preparation of the derivant PEG-4 of polyalkylene glycol acrylate containing tetramethyl：
4g Polyethylene Glycol is added in the dichloromethane of 50mL, adds 1g triethylamine, mixed liquor is cooled to 0 DEG C.Then
The dichloromethane solution of 1g methacrylic chloride is added dropwise in reaction system, reacts continuously stirred 12 hours.Then by sample
Load in bag filter and dialyse (molecular cut off 3500), dialysed 4 days using pure water, change a dialysis solution for every eight hours.Finally receive
Solution in collection Dialysis tubing, lyophilization obtains white fluffy solid.
Embodiment 4
The preparation of acrylate derivative H-3：
The 1,4- dioxane of 50mL water for injection and 75mL is added in the hyaluronic acid aqueous solution of the 1wt% of 100mL；Thereto plus
Enter 3mL glycidyl thiophene acrylate, then stir 24 hours in 50 DEG C of thermostatic container；Add sodium chloride to gained
To solution in, be followed by stirring for, and pour the mixture into and in 800mL ethanol, obtain continuous shape precipitation.Fully rinse institute with ethanol
The H-3 precipitating and obtaining after being dried 1.1g obtaining.
Hyaluronic acid preferred molecular weight 20000 to 3000000, more preferably molecular weight 100000 to 2000000, and more preferably
Molecular weight 200000 to 1200000.
Embodiment 5
Configuration component solution A：By 0.5mL2% (mass ratio) sulfydryl matter acid derivative, 0.5mL15% (mass ratio) water solublity forms sediment
Powder solution, 1mL20 polyvinyl alcohol, 0.5mL propylene glycol is added to standby in 20mL syringe；
Configuration component B solution：Borate buffer solution configuration 2% (mass ratio) acrylate derivative being 9.5 with pH, standby；
Component solution A is sprayed on glass plate, then component B is sprayed on component solution A, it is possible to find after 10s, form one layer of tool
There are certain viscosity and the hydrogel layer of elasticity.
Embodiment 6
The impact to crosslinking time for the pH.
Embodiment 7
The impact to crosslinking time for the concentration (mass ratio) of component A and component B
1With distilling water dissolution, concentration is 2% (mass ratio)
2With boric acid-sodium hydrate buffer solution (pH=11.0) dissolving.Concentration is A+B after 2% (mass ratio) mixing, and concentration is respectively
1% (mass ratio).
Embodiment 8
The present invention is used for the test of the liquid bandage water retention property of War injury.Test shows, sample 4, No. 5 and No. 9 performances
Go out excellent water retention property.Preferably propylene glycol is as water-retaining agent.
Embodiment 9
The present invention is used for the optimization Test of each component of the liquid bandage of War injury.The experimental condition of preferred sample 8.
The above is only the preferred embodiment of the present invention it is noted that ordinary skill people for the art
For member, some improvement can also be made under the premise without departing from the principles of the invention, these improvement also should be regarded as the present invention's
Protection domain.
Claims (12)
1. a kind of liquid bandage for War injury it is characterised in that：Including sulfydryl matter acid derivative, acrylate derivative,
Viscosifier, wetting agent, preservative, borate buffer solution and deionized water.
2. the liquid bandage for War injury according to claim 1 it is characterised in that：Described sulfydryl matter acid derivative
Accounting for gross weight ratio is：0.5-5%, described acrylate derivative accounts for gross weight than for 0.5-5%, and described viscosifier account for gross weight ratio
For 3-20%, described wetting agent accounts for gross weight than for 5-35%, and described preservative accounts for gross weight than for 0.05-1%, described deionization
Water accounts for gross weight than for 20-60%.
3. the liquid bandage for War injury according to claim 1 and 2 it is characterised in that：Described sulfydryl matter acid is derivative
Thing is one kind of H-1, H-2 or two kinds.
4. the liquid bandage for War injury according to claim 1 and 2 it is characterised in that：Described sulfydryl matter acid is derivative
Thing at least contains three sulfydryls.
5. the liquid bandage for War injury according to claim 1 and 2 it is characterised in that：Described acrylate derives
Thing is tetramethyl acrylate derivative.
6. the liquid bandage for War injury according to claim 1 and 2 it is characterised in that：Described acrylate derives
Thing be one kind of PEG-2, PEG-4, H-3 or two kinds and more than.
7. the liquid bandage for War injury according to claim 1 and 2 it is characterised in that：Described viscosifier are water-soluble
In property starch, Polyvinylpyrrolidone, polyvinyl alcohol, gelatin, carboxymethyl cellulose, polyvidone, collagen protein, vegetable polysaccharidess
One or more.
8. the liquid bandage for War injury according to claim 1 and 2 it is characterised in that：Described wetting agent be glycerol,
One or more of propylene glycol, Polyethylene Glycol, glycerol, Sorbitol.
9. the liquid bandage for War injury according to claim 8 it is characterised in that：Described wetting agent is isopropanol.
10. the liquid bandage for War injury according to claim 1 and 2 it is characterised in that：Described preservative is to hydroxyl
Yl benzoic acid esters, benzoic acid and its salt, sorbic acid and its salt, this bundle bromo-amine, one or more of chlorhexidine acetate.
11. liquid bandage for War injury according to claim 10 it is characterised in that：Described preservative is nipalgin
Ester, it accounts for total mass ratio is 0.05%-0.1%.
12. liquid bandage for War injury according to claim 1 it is characterised in that：The pH value of borate buffer solution
For 9.5-11.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610906714.8A CN106474536A (en) | 2016-10-18 | 2016-10-18 | A kind of liquid bandage for War injury |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610906714.8A CN106474536A (en) | 2016-10-18 | 2016-10-18 | A kind of liquid bandage for War injury |
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| Publication Number | Publication Date |
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| CN106474536A true CN106474536A (en) | 2017-03-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610906714.8A Pending CN106474536A (en) | 2016-10-18 | 2016-10-18 | A kind of liquid bandage for War injury |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929804A (en) * | 2017-12-26 | 2018-04-20 | 常州百瑞吉生物医药有限公司 | Modified gelatin base composite sponge and its preparation method and application |
| CN109432480A (en) * | 2018-12-05 | 2019-03-08 | 大连大学 | A kind of wet active carbon loading silver fiber dressing of long acting antibiotic control and preparation method thereof |
| US11446256B1 (en) | 2021-08-20 | 2022-09-20 | Advantice Health, Llc | Aqueous wound healing formulation |
| CN115721770A (en) * | 2021-08-31 | 2023-03-03 | 苏州清蓝生物医药科技有限公司 | Hemostatic composition and application thereof as liquid bandage |
| CN115721773A (en) * | 2021-08-31 | 2023-03-03 | 苏州清蓝生物医药科技有限公司 | Preparation method of liquid bandage |
| CN116135222A (en) * | 2021-11-17 | 2023-05-19 | 苏州清蓝生物医药科技有限公司 | Hemostatic composition containing cannabidiol and application of hemostatic composition as liquid bandage |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929804A (en) * | 2017-12-26 | 2018-04-20 | 常州百瑞吉生物医药有限公司 | Modified gelatin base composite sponge and its preparation method and application |
| CN109432480A (en) * | 2018-12-05 | 2019-03-08 | 大连大学 | A kind of wet active carbon loading silver fiber dressing of long acting antibiotic control and preparation method thereof |
| US11446256B1 (en) | 2021-08-20 | 2022-09-20 | Advantice Health, Llc | Aqueous wound healing formulation |
| US11844869B2 (en) | 2021-08-20 | 2023-12-19 | Advantice Health, Llc | Aqueous wound healing formulation |
| CN115721770A (en) * | 2021-08-31 | 2023-03-03 | 苏州清蓝生物医药科技有限公司 | Hemostatic composition and application thereof as liquid bandage |
| CN115721773A (en) * | 2021-08-31 | 2023-03-03 | 苏州清蓝生物医药科技有限公司 | Preparation method of liquid bandage |
| CN116135222A (en) * | 2021-11-17 | 2023-05-19 | 苏州清蓝生物医药科技有限公司 | Hemostatic composition containing cannabidiol and application of hemostatic composition as liquid bandage |
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