CN101982202A - Medical hydrogel dressings and preparation method thereof - Google Patents
Medical hydrogel dressings and preparation method thereof Download PDFInfo
- Publication number
- CN101982202A CN101982202A CN2010105287118A CN201010528711A CN101982202A CN 101982202 A CN101982202 A CN 101982202A CN 2010105287118 A CN2010105287118 A CN 2010105287118A CN 201010528711 A CN201010528711 A CN 201010528711A CN 101982202 A CN101982202 A CN 101982202A
- Authority
- CN
- China
- Prior art keywords
- starch
- water
- dressing
- solution
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 34
- 238000003756 stirring Methods 0.000 claims abstract description 28
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 27
- 229920002472 Starch Polymers 0.000 claims abstract description 27
- 239000008107 starch Substances 0.000 claims abstract description 27
- 235000019698 starch Nutrition 0.000 claims abstract description 27
- 239000000243 solution Substances 0.000 claims abstract description 26
- 239000011259 mixed solution Substances 0.000 claims abstract description 18
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 14
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 239000008367 deionised water Substances 0.000 claims description 18
- 229910021641 deionized water Inorganic materials 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 16
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 14
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 14
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 13
- 238000010792 warming Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 9
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims description 6
- 238000006136 alcoholysis reaction Methods 0.000 claims description 5
- 238000006116 polymerization reaction Methods 0.000 claims description 5
- 229920001592 potato starch Polymers 0.000 claims description 5
- UWFRVQVNYNPBEF-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(C)C=C1C UWFRVQVNYNPBEF-UHFFFAOYSA-N 0.000 claims description 4
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 claims description 4
- 229920001817 Agar Polymers 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 239000008272 agar Substances 0.000 claims description 4
- 235000010418 carrageenan Nutrition 0.000 claims description 4
- 239000000679 carrageenan Substances 0.000 claims description 4
- 229920001525 carrageenan Polymers 0.000 claims description 4
- 229940113118 carrageenan Drugs 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 229960000789 guanidine hydrochloride Drugs 0.000 claims description 4
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
- SYEWHONLFGZGLK-UHFFFAOYSA-N 2-[1,3-bis(oxiran-2-ylmethoxy)propan-2-yloxymethyl]oxirane Chemical compound C1OC1COCC(OCC1OC1)COCC1CO1 SYEWHONLFGZGLK-UHFFFAOYSA-N 0.000 claims description 3
- 229920002261 Corn starch Polymers 0.000 claims description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 3
- QVYARBLCAHCSFJ-UHFFFAOYSA-N butane-1,1-diamine Chemical compound CCCC(N)N QVYARBLCAHCSFJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000008120 corn starch Substances 0.000 claims description 3
- PWGJDPKCLMLPJW-UHFFFAOYSA-N 1,8-diaminooctane Chemical compound NCCCCCCCCN PWGJDPKCLMLPJW-UHFFFAOYSA-N 0.000 claims description 2
- STMDPCBYJCIZOD-UHFFFAOYSA-N 2-(2,4-dinitroanilino)-4-methylpentanoic acid Chemical compound CC(C)CC(C(O)=O)NC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O STMDPCBYJCIZOD-UHFFFAOYSA-N 0.000 claims description 2
- 244000017020 Ipomoea batatas Species 0.000 claims description 2
- 235000002678 Ipomoea batatas Nutrition 0.000 claims description 2
- FDLQZKYLHJJBHD-UHFFFAOYSA-N [3-(aminomethyl)phenyl]methanamine Chemical compound NCC1=CC=CC(CN)=C1 FDLQZKYLHJJBHD-UHFFFAOYSA-N 0.000 claims description 2
- YQLZOAVZWJBZSY-UHFFFAOYSA-N decane-1,10-diamine Chemical compound NCCCCCCCCCCN YQLZOAVZWJBZSY-UHFFFAOYSA-N 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims description 2
- 238000006068 polycondensation reaction Methods 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 4
- 206010048038 Wound infection Diseases 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 238000001816 cooling Methods 0.000 abstract description 2
- 230000009545 invasion Effects 0.000 abstract description 2
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000002522 swelling effect Effects 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 description 51
- 206010052428 Wound Diseases 0.000 description 50
- 239000000499 gel Substances 0.000 description 28
- 238000000034 method Methods 0.000 description 20
- 229940068984 polyvinyl alcohol Drugs 0.000 description 12
- 230000005855 radiation Effects 0.000 description 10
- 230000029663 wound healing Effects 0.000 description 9
- 230000035876 healing Effects 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 6
- 239000000835 fiber Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000004964 aerogel Substances 0.000 description 5
- 210000000416 exudates and transudate Anatomy 0.000 description 5
- 239000004744 fabric Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- -1 polypropylene Polymers 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 229920005615 natural polymer Polymers 0.000 description 4
- 229920001661 Chitosan Polymers 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- 206010053615 Thermal burn Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 150000002357 guanidines Chemical class 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- JCVJEEJXXIFPCD-UHFFFAOYSA-N 1-methylideneguanidine;hydrochloride Chemical class Cl.NC(=N)N=C JCVJEEJXXIFPCD-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000008952 bacterial invasion Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000011262 co‐therapy Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000004915 pus Anatomy 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000004154 testing of material Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a medical hydrogel dressings and a preparation method thereof. The hydrogel dressings is prepared by taking 10-30% by mass of starch and 2-15% by mass of water-soluble polymer as raw materials, utilizing a guanidinesalt polycondensate as an anti-bacterial agent, adding a cross-linking agent, and reacting at the temperature of 40-80 DEG C. The operation steps are as follows: adding the starch and the water-soluble polymer in a solvent to prepare into a solution, regulating the pH value of the solution by a NaOH solution, heating for gelatinization, cooling, adding the anti-bacterial agent and the cross-linking agent, stirring to form a mixed solution, pouring the mixed solution into a die, and reacting at the temperature of 40-80 DEG C to obtain the anti-bacterial hydrogel. Compared with the prior art, the hydrogel dressings in the invention has the advantages of good swelling property, high transparency, moderate mechanic strength, excellent bacteria invasion resistance, wide raw material sources, cheap raw materials, good tissue compatibility and favorable medical application prospect, and can effectively prevent wound infection.
Description
Technical field
The present invention relates to dressing of a kind of burn, scald and traumatic wounds use and preparation method thereof, especially relate to a kind of medical aquogel dressing and preparation method thereof.
Background technology
Skin is the barrier of keeping homoiostasis and stoping the microorganism invasion.Owing to reasons such as wound, scratch, burn and skin ulcerations, may cause the injury on a large scale of skin.It is people's general knowledge that wound infects easily, and this breeds on wound easily and cause owing to pathogen such as staphylococcus aureus, candidiasis and escherichia coli.The wound that infects is difficult for healing, causes the body fluid loss easily and causes various complication.Though traditional dressing has protective effect to wound surface; but do not think that generally it has facilitation to wound healing; the damage granulation tissue then postpones wound healing on the contrary during as change dressings more, and the bacterial resistance that the topical application antibiotic causes in the gauze dressing more makes infective wound surface be difficult to healing.
Doctor Winter of London University in 1962 has invented " wet method therapy ", he finds in zoopery, to be exposed to the air drying wound surface fast again for the speed of wound healing ratio under airtight moist environment, thereby established the theoretical basis that adopts the processing wound surface of new pattern compress.Now prove, use moisture-preserving dressing can give wound the local wet condition of creating an imitation wound surface blister physiological healing, wound re-epithelialization ability is significantly improved, wound surface is healed at faster speed.Therefore, aerogel dressing arises at the historic moment.
Hydrogel is can swelling in water and keep the undissolvable again cross linked polymer of large quantity of moisture.Hydrogel has excellent biological compatibility, is widely used in multiple fields such as food, medicine.One of important use of medical aquogel is that such dressing water content reaches 96%, can keep the moist environment of wound surface as wound dressing; Repeatedly hydration, the exudate of continuous absorption wound can take place when contacting with tissue; Hydrogel thermal capacity is big, so gentle cooling effect is arranged, can significantly reduce the pain and the inflammation of postoperative; The translucent healing state of observing wound that is beneficial to.But such dressing is not strong to the buffer action of antibacterial, and the alternative gram-negative bacteria that allows is grown; Easily polluting needs duty to change dressings.
The main preparation methods of hydrogel has chemical method, radiation method and freeze-thaw method etc.Chemical method prepares needs to add a spot of cross-linking agent in the hydrogel process, be to prepare hydrogel method the most commonly used, and the hydrogel character of generation is subjected to the influence of cross-linking monomer, cross-linking agent and reaction condition.Radiation method causes the crosslinked hydrogel that makes by high-energy radiation, and its process need not added chemical cross-linking agent and initiator etc., and product is pure; Radiation can at room temperature be carried out, the reaction condition gentleness, and can be by control properties of product such as control radiation dose; Gel formation can carry out simultaneously with sterilization simultaneously.But mechanical strength is less generally speaking for the hydrogel of radiation method preparation, and is very high to equipment requirements, need electron linear accelerator or
60The Co therapy apparatus is restricted its extensive use.Freeze-thaw method is a kind of very effective method of being reported the earliest by Peppas for preparing polyvinyl alcohol (PVA) hydrogel.The hydrogel that this method makes has advantages such as good springiness and mechanical strength be big, but this hydrogel is a kind of physical gel, can be dissolved into solution when higher temperature; And the swellbility of hydrogel is less and opaque, influences in the therapeutic process observation to wound.The freezing thawing time of reporting in the document is 8～24h usually, and manufacturing cycle is long, is unfavorable for the production of product.
Synthetic high polymer and natural polymer are the materials of present modal preparation hydrogel.Natural polymer because have better biocompatibility and Biodegradable, can not cause rejection or cause wound infection, to the sensitivity of environment and abundant source, cheap price, be subjected to attention widely.
In existing patent documentation about aerogel dressing, Chinese patent CN 1225370 has introduced a kind of method for radio-grafting of medical high molecular aquagel membrane.This kind aquagel membrane is a raw material with polyethylene glycol oxide, polyvinyl alcohol, water, and through mold, cold cycling treatment, processing steps such as RADIATION PROCESSING are made aquagel membrane.Though this kind aquagel membrane has possessed the ability that absorbs and keep the wound exudate, but the water holding capacity of hydrogel is limited, also do not have in the hydrogel can the local antibacterials of using, and increased wound the danger that infects takes place, and have also increased the workload that medical personnel frequently change dressings.
Patent CN 2383500 provides a kind of hydrogel compounded dressing for wound, wet, permeability that this aquagel membrane has, but do not have in the gel to suppress or the composition of kill bacteria, do not possess antibacterial ability initiatively, be easy to cause traumatic infection.
Patent CN 1579559A discloses polyvinyl alcohol hydrogel wound dressing of a kind of pastille, chitosan and preparation method thereof.Contain chitosan in its prescription, but chitosan is water insoluble, and is dissolved in dilute acid soln, thus in preparation process, need the acid neutralization, otherwise dressing has stimulation to wound; This aerogel dressing also contains additives such as wetting agent, plasticizer, and these additives are easy to separate out in the use of dressing, and wound is had certain side effect; Circulating freezing resistance step in its preparation method, the time is longer, and the freezing and thawing time all needs 8～30 hours, influences its production efficiency.
Patent CN 101664563A discloses a kind of preparation method of anti-bacterial hydrogel dressing, with acrylamide, Polyethylene Glycol double methacrylate cross-linking agent with contain the water-soluble liquid-phase mixing of natural polymer of nanometer Ag, places under the room temperature then
60Co source cross-linking radiation gets anti-bacterial hydrogel dressing.Adopting the anti-bacterial hydrogel dressing of this method preparation is a kind of holey dressing with anti-microbial property and hydrating capacity, but that have antibacterial activity in this dressing is Ag
+, easy oxidation discoloration and enter human body by wound may cause harmful effect to health, and safety leaves a question open.
It is gel dressing that the Patent Application No.83305770.6 of EUROPEAN PATENT OFFICE discloses by " the Therapeutic Gel Dressing " of Johnson research and development-treatment.This is a kind of polyvinylpyrrolidone gel of the electron beam crosslinking by 1-5 millirad radiation dose; in manufacturing process, in dressing, add different medicaments, SSD (a kind of antibiotic preparation commonly used) for example, this gel is except absorbing the wound transudate; can also killing bacteria, the protection wound.Its shortcoming is that the gel dressing color of the interpolation medicament that makes under electron radiation is mottled, presents Huang, purple, different colours such as green, brown, and along with time variable color gradually, can influence the observation to the wound situation like this.
United States Patent (USP) United States Patent No.4294241, Miyata and Teruo have invented a kind of collagen dressing for skin.It adopts the decomposition of protein enzyme to handle collagen, forms molecular solution, through purification post-treatment flakiness shape Wound dressing.It has good skin compatibility, can quicken epithelial renewal, to organizing nonirritant.This series products water absorption rate is not high, therefore comparatively is fit to this class drying property wound of incised wound property.If the wound surface has more transudate or pus and blood then not too suitable.
Patent US 2009/0326496 A1 has invented a kind of transparent aquagel wound dressing, and this dressing comprises the gel formation fabric and strengthens the sheet-like hydrous gel polymer, and this fabric can absorb wound fluid and can see through dressing observes wound.The gel formation fiber is sodium alginate fiber, viscose rayon, modified cellulose, cellulose, polyester fiber, polypropylene and copolymer thereof, pectin, chitin fiber, hyaluronic acid fiber or other polysaccharide fiber.Hydrogel layer is then chosen from polyurethane adhesive, biopolymer gel, carboxymethyl cellulose gel, hydroxyethyl-cellulose gel, hydroxypropyl emthylcellulose, modified propylene amide and composition thereof.Gel takes place crosslinked by covalent bond or ionic bond.By extruder aquogel polymer is filled on the reinforced fabric, then dressing is pressed into lamellar.In addition, strengthening hydrogel can be by applying or steep water gel monomer on reinforced fabric, monomer is reacted and makes.
In addition, though commercially available aquogel type wound dressing has solved problems such as absorption transudate, breathability, obstruct antibacterial, waterproof, wound comfort level, but for the intensity that increases hydrogel, the cohesive that strengthens hydrogel and waterproof and breathable notacoria, majority has adopted fabric or non-woven fabrics as enhancement Layer, and taked the complicated technology of MULTILAYER COMPOSITE, resulting product is opaque structure like this, is not easy to observe the wound healing situation.
Summary of the invention
Purpose of the present invention is exactly to provide a kind of healing of wound, medical aquogel dressing that antibacterial effect is lasting, production cost is lower and preparation method thereof of promoting for the defective that overcomes above-mentioned prior art existence.
Purpose of the present invention can be achieved through the following technical solutions:
A kind of medical aquogel dressing is characterized in that, this dressing comprises following component and content (wt%):
Starch 10～30;
Water soluble polymer 2～15;
Cross-linking agent 0.5～10;
Antibacterial 0.1～5;
The solvent surplus.
Described starch is corn starch, wheaten starch, potato starch, soluble starch, sweet potato starch or green starch.
Described water soluble polymer is selected from one or more in polyvinyl alcohol, polyvinylpyrrolidone, carrageenan, gelatin or the agar.
The degree of polymerization of described polyvinyl alcohol is 1200～10000, and alcoholysis degree is 90～100%.
The molecular weight of described polyvinylpyrrolidone is 300000～1000000.
Described cross-linking agent is selected from one or more in epoxychloropropane, Ethylene glycol diglycidyl ether, glutaraldehyde, allyl glycidyl ether, trihydroxy propane triglycidyl ether or the glycerol triglycidyl ether.
Described antibacterial is the water solublity organic antibacterial agent, is selected from the melt polycondensation thing of butanediamine, hexamethylene diamine, octamethylenediamine, decamethylene diamine or m-xylene diamine and guanidine hydrochloride.
Described solvent is a deionized water.
A kind of preparation method of medical aquogel dressing may further comprise the steps:
(1) get the raw materials ready according to following component and kind degree:
Starch 10～30,
Water soluble polymer 2～15,
Cross-linking agent 0.5～10,
Antibacterial 0.1～5,
The solvent surplus;
(2) the water intaking soluble macromolecular is dissolved in the solvent deionized water, stirs, and makes water-soluble polymer solution, and starch is scattered in the water, makes starch dispersion liquid;
(3) with water-soluble polymer solution in the step (2) and starch dispersion liquid mix homogeneously, with NaOH solution regulation system pH value to 7～13, be warming up to 50～100 ℃ then and keep 5～30min, be cooled to 30～50 ℃;
(4) by formulation content antibacterial is joined in the reaction system that step (3) obtains, stir;
(5) add cross-linking agent by formulation content in the solution that step (4) obtains, stir and form mixed solution, pour mixed solution into mould, 40～80 ℃ are reacted 2～6h down and promptly get anti-bacterial hydrogel dressing.
Compared with prior art, the present invention has the following advantages:
(1) utilize the hydrogel wound dressing of the inventive method preparation to have higher swellbility, can absorb wound fluid in a large number and keep the moist environment of wound, can the adhesion wound, the secondary damage that has brought when having reduced more change dressings, reduced medical personnel's workload, and make wound be in a stable moist environment, promote the healing of wound;
(2) utilize the hydrogel wound dressing of the inventive method preparation to have the function of excellent opposing bacterial invasion, can prevent wound infection effectively, help the healing of wound, and save this step of dressing sterilization, simplify technology, reduced production cost;
(3) antibacterial of the present invention is organic guanidine class antibacterial, and it is based on physical action and the antibiotic mechanism of killing microorganisms makes aerogel dressing in use can not bring drug-fast problem;
(4) organic guanidine class antibacterial molecule of Cai Yonging is to be incorporated on the strand of starch gel with the chemical bond formal bond, even decocting in water, solvent pop also difficulty break away from antibacterial functions group, thereby can avoid human body to take in the antibacterial of stripping and cause murder by poisoning, and antibacterial effect is lasting;
(5) utilizing the hydrogel wound dressing of the inventive method preparation is matrix with natural polymer starch, raw material sources are extensively cheap, and no cytotoxicity and acute toxicity are to skin nonirritant and sensitization, histocompatibility is good, therefore has good medical application prospect.
The specific embodiment
The present invention is described in detail below in conjunction with specific embodiment.
Below the performance test methods of hydrogel among each embodiment, be summarized as follows:
(1) gel fraction: after the hydrogel drying, be solvent with the deionized water, apparatus,Soxhlet's extracting 24h:
Gel dry weight * 100% before gel fraction=(gel dry weight after the preceding gel dry weight-extracting of extracting)/extracting;
(2) secondary swelling ratio: the dry back 25 ℃ of abilities that absorb deionized water down of hydrogel:
Gel dry weight * 100% before secondary swelling ratio %=(the preceding gel dry weight of gel weight-suction after the suction balance)/suction;
(3) gel strength: use the Lloyd Material Testing Machine to measure and penetrate the required power of starch gel certain depth, the active force of the probe gel that puts on is defined as gel strength when gel breaks;
(4) anti-microbial property: carry out according to the bacteriostatic experiment method FZ/T01021-92 in the health ministry disinfection technology standard in 1992;
(5) wound healing experiment: laboratory animal adopts male Wistar rat, and point of observation is respectively hindered the back 3,5,10,18 days.Rat back is anaesthetized behind the 24h with 8% sodium sulfide loss of thick fluid hair, scalds with 80 ℃ of water-baths then and causes rat back 10% dark II degree skin scald in 15 seconds, hinders after the abdominal cavity gives 5mL normal saline.Respectively with the anti-bacterial hydrogel dressing flap coverage of embodiment gained; With the hospital gauze flap coverage, organize as a comparison; Put the wound healing rate of calculating observing time:
Wound healing rate=(original wound surface area-the wound surface area does not heal)/original wound surface area.
Embodiment 1
10g pva powder and 5g agar are scattered in the 70g deionized water, are warming up to 85 ℃ of dissolvings, be cooled to 40 ℃, wherein the degree of polymerization of polyvinyl alcohol is 2400, and alcoholysis degree is 99%; The 10g wheaten starch is scattered in the 10g deionized water, joins in above-mentioned polyvinyl alcohol and the agar solution, stir,, be warming up to 95 ℃ then and keep 20min, be cooled to 30 ℃ with 3wt%NaOH solution regulation system pH value to 9; It is that 2% aqueous solution joins in the reaction system that 0.8g polytetramethylene guanidine hydrochloride is mixed with mass concentration, stirs; Add the 5g epoxychloropropane again, stir and form mixed solution, pour mixed solution into mould, place 60 ℃ of reaction 3h down, get anti-bacterial hydrogel dressing.
Embodiment 2
The 10g polyvinylpyrrolidonepowder powder is scattered in the 50g deionized water, stirring and dissolving, wherein the molecular weight of polyvinylpyrrolidone is 1000000; The 15g potato starch is scattered in the 30g deionized water, joins in the above-mentioned polyvinylpyrrolidonesolution solution, stir,, be warming up to 80 ℃ then and keep 30min, be cooled to 40 ℃ with 2wt%NaOH solution regulation system pH value to 10; It is that 5% aqueous solution joins in the reaction system that 1.6g polyhexamethylene guanidine hydrochloride is mixed with mass concentration, stirs; Add the 4g Ethylene glycol diglycidyl ether again, stir and form mixed solution, pour mixed solution into mould, place 75 ℃ of reaction 3h down, get anti-bacterial hydrogel dressing.
Embodiment 3
5g pva powder and 2g gelatin are scattered in the 20g deionized water, are warming up to 85 ℃ of dissolvings, be cooled to 40 ℃, wherein the degree of polymerization of polyvinyl alcohol is 8000, and alcoholysis degree is 91.5%; The 18g soluble starch is scattered in the 60g deionized water, joins in above-mentioned polyvinyl alcohol and the gelatin solution, stir,, be warming up to 85 ℃ then and keep 15min, be cooled to 30 ℃ with 4wt%NaOH solution regulation system pH value to 11; It is that 10% aqueous solution joins in the reaction system that the poly-eight methylene guanidine hydrochlorides of 3.0g are mixed with mass concentration, stirs; Add 6g glycerol triglycidyl ether again, stir and form mixed solution, pour mixed solution into mould, place 70 ℃ of reaction 4h down, get anti-bacterial hydrogel dressing.
Embodiment 4
10g polyvinylpyrrolidonepowder powder and 5g carrageenan are scattered in the 65g deionized water, stirring and dissolving, wherein the molecular weight of polyvinylpyrrolidone is 800000; The 10g green starch is scattered in the 15g deionized water, joins in above-mentioned polyvinylpyrrolidone and the carrageenan solutions, stir,, be warming up to 85 ℃ then and keep 30min, be cooled to 30 ℃ with 4wt%NaOH solution regulation system pH value to 11; With 1.6g poly-between the xyxylene guanidine hydrochloride to be mixed with mass concentration be that 5% aqueous solution joins in the reaction system, stir; Add 4g trihydroxy propane triglycidyl ether again, stir and form mixed solution, pour mixed solution into mould, place 60 ℃ of reaction 4h down, get anti-bacterial hydrogel dressing.
Embodiment 5
The 2g pva powder is scattered in the 20g deionized water, is warming up to 70 ℃ of dissolvings, be cooled to 40 ℃, wherein the degree of polymerization of polyvinyl alcohol is 1200, and alcoholysis degree is 90%; The 20g corn starch is scattered in the 60g deionized water, joins in the above-mentioned poly-vinyl alcohol solution, stir,, be warming up to 50 ℃ then and keep 30min, be cooled to 30 ℃ again with 4wt%NaOH solution regulation system pH value to 7; It is that 2% aqueous solution joins in the reaction system that the mixture of 0.1g butanediamine and hexamethylene diamine is mixed with mass concentration, stirs; Add the 0.5g epoxychloropropane again, stir and form mixed solution, pour mixed solution into mould, place 40 ℃ of following reaction 6h promptly to get anti-bacterial hydrogel dressing.
Embodiment 6
The 10g polyvinylpyrrolidonepowder powder is scattered in the 40g deionized water, stirring and dissolving, wherein the molecular weight of polyvinylpyrrolidone is 300000; The 20g wheaten starch is scattered in the 30g deionized water, joins in the above-mentioned polyvinylpyrrolidonesolution solution, stir,, be warming up to 100 ℃ then and keep 5min, be cooled to 50 ℃ again with 4wt%NaOH solution regulation system pH value to 13; With 5g poly-between the xyxylene guanidine hydrochloride to be mixed with mass concentration be that 15% aqueous solution joins in the reaction system, stir; The mixture that adds 10g Ethylene glycol diglycidyl ether and glutaraldehyde again stirs and forms mixed solution, pours mixed solution into mould, places 80 ℃ of following reaction 2h promptly to get anti-bacterial hydrogel dressing.The performance of the anti-bacterial hydrogel dressing that embodiment 1～6 obtains is as shown in table 1.
Every performance of the aerogel dressing for preparing among each embodiment of table 1
The performance of the wound healing of embodiment 1～6 is as shown in table 2.
Table 2 wound healing experimental result
Claims (9)
1. a medical aquogel dressing is characterized in that, this dressing comprises following component and content (wt%):
Starch 10～30;
Water soluble polymer 2～15;
Cross-linking agent 0.5～10;
Antibacterial 0.1～5;
The solvent surplus.
2. a kind of medical aquogel dressing according to claim 1 is characterized in that described starch is corn starch, wheaten starch, potato starch, soluble starch, sweet potato starch or green starch.
3. a kind of medical aquogel dressing according to claim 1 is characterized in that described water soluble polymer is selected from one or more in polyvinyl alcohol, polyvinylpyrrolidone, carrageenan, gelatin or the agar.
4. a kind of medical aquogel dressing according to claim 3 is characterized in that the degree of polymerization of described polyvinyl alcohol is 1200～10000, and alcoholysis degree is 90～100%.
5. a kind of medical aquogel dressing according to claim 3 is characterized in that the molecular weight of described polyvinylpyrrolidone is 300000～1000000.
6. a kind of medical aquogel dressing according to claim 1, it is characterized in that described cross-linking agent is selected from one or more in epoxychloropropane, Ethylene glycol diglycidyl ether, glutaraldehyde, allyl glycidyl ether, trihydroxy propane triglycidyl ether or the glycerol triglycidyl ether.
7. a kind of medical aquogel dressing according to claim 1 is characterized in that described antibacterial is the water solublity organic antibacterial agent, is selected from the melt polycondensation thing of butanediamine, hexamethylene diamine, octamethylenediamine, decamethylene diamine or m-xylene diamine and guanidine hydrochloride.
8. a kind of medical aquogel dressing according to claim 1 is characterized in that described solvent is a deionized water.
9. the preparation method of a medical aquogel dressing as claimed in claim 1 may further comprise the steps:
(1) get the raw materials ready according to following component and kind degree:
Starch 10～30,
Water soluble polymer 2～15,
Cross-linking agent 0.5～10,
Antibacterial 0.1～5,
The solvent surplus;
(2) the water intaking soluble macromolecular is dissolved in the solvent deionized water, stirs, and makes water-soluble polymer solution, and starch is scattered in the water, makes starch dispersion liquid;
(3) with water-soluble polymer solution in the step (2) and starch dispersion liquid mix homogeneously, with NaOH solution regulation system pH value to 7～13, be warming up to 50～100 ℃ then and keep 5～30min, be cooled to 30～50 ℃;
(4) by formulation content antibacterial is joined in the reaction system that step (3) obtains, stir;
(5) add cross-linking agent by formulation content in the solution that step (4) obtains, stir and form mixed solution, pour mixed solution into mould, 40～80 ℃ are reacted 2～6h down and promptly get anti-bacterial hydrogel dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010528711 CN101982202B (en) | 2010-11-02 | 2010-11-02 | Medical hydrogel dressings and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010528711 CN101982202B (en) | 2010-11-02 | 2010-11-02 | Medical hydrogel dressings and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101982202A true CN101982202A (en) | 2011-03-02 |
| CN101982202B CN101982202B (en) | 2013-09-18 |
Family
ID=43619125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010528711 Expired - Fee Related CN101982202B (en) | 2010-11-02 | 2010-11-02 | Medical hydrogel dressings and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101982202B (en) |
Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908648A (en) * | 2012-10-24 | 2013-02-06 | 合肥工业大学 | Gel type paeonol air freshener |
| CN105496566A (en) * | 2015-12-14 | 2016-04-20 | 清华大学 | Medical multi-layer composite anti-adhesion membrane and preparation method thereof |
| CN105597143A (en) * | 2016-02-01 | 2016-05-25 | 山东省药学科学院 | Method for preparing styptic powder by pure aqueous phase |
| CN105920654A (en) * | 2016-04-27 | 2016-09-07 | 李明华 | Burn dressing applicable to department of burn and having antibacterial effect |
| CN106039395A (en) * | 2016-08-11 | 2016-10-26 | 潘忠宁 | Preparation method of bonded antibacterial hydrogel dressing |
| CN106620830A (en) * | 2016-12-09 | 2017-05-10 | 苏州纳贝通环境科技有限公司 | Medical tissue regeneration-promoting hydrogel dressing and preparation method thereof |
| CN108424533A (en) * | 2018-05-30 | 2018-08-21 | 中国科学院兰州化学物理研究所 | A kind of 3D printing bio-medical hydrogel and preparation method thereof |
| CN108478470A (en) * | 2018-04-24 | 2018-09-04 | 上海益好纳米科技有限公司 | A kind of carrier-free can absorb type gel mask and preparation method thereof |
| CN108530652A (en) * | 2018-03-29 | 2018-09-14 | 钦州学院 | A kind of converted starch plural gel and its preparation method and application |
| CN110157019A (en) * | 2019-05-17 | 2019-08-23 | 韩建中 | A kind of PVA gelatine starch hydrogel preparation method |
| CN110330658A (en) * | 2019-06-14 | 2019-10-15 | 浙江工业大学 | A kind of sterilization, low bacterial adhesion, the anti-bacterial hydrogel of bacterium release and its preparation method and application |
| CN110786989A (en) * | 2019-10-28 | 2020-02-14 | 安庆师范大学 | Preparation method of medical antibacterial gel dressing |
| CN111729123A (en) * | 2020-06-29 | 2020-10-02 | 苏州凝智新材料发展有限公司 | Suture-free hydrogel adhesive plaster for tissue wound closure and preparation method thereof |
| CN111870734A (en) * | 2020-08-19 | 2020-11-03 | 山东东贝医药科技有限公司 | Preparation method of medical antibacterial healing-promoting hydrogel dressing |
| CN112121225A (en) * | 2020-10-16 | 2020-12-25 | 广西大学 | Nanocomposite hydrogel for bleeding control and preparation method thereof |
| CN113058072A (en) * | 2021-03-16 | 2021-07-02 | 卫纳塞德(北京)医疗科技有限公司 | Antibacterial medical cold compress hydrogel and preparation method thereof |
| CN113058073A (en) * | 2021-03-16 | 2021-07-02 | 卫纳塞德(北京)医疗科技有限公司 | Cold compress type medical hydrogel and preparation method thereof |
| CN113136040A (en) * | 2021-05-08 | 2021-07-20 | 中国科学院华南植物园 | Cationic starch gel and preparation method and application thereof |
| CN113244443A (en) * | 2021-04-28 | 2021-08-13 | 广州大学 | Hydrogel dressing and preparation method and application thereof |
| CN114010836A (en) * | 2021-11-29 | 2022-02-08 | 深圳先进技术研究院 | Hemostatic dressing and preparation method thereof |
| CN114272434A (en) * | 2021-03-16 | 2022-04-05 | 卫纳塞德(北京)医疗科技有限公司 | Degradable medical cold compress hydrogel and preparation method thereof |
| CN114767933A (en) * | 2022-04-02 | 2022-07-22 | 伊索曼(中山)医疗器械有限公司 | Hydrogel and preparation method thereof |
| CN114796502A (en) * | 2021-06-23 | 2022-07-29 | 四川大学华西医院 | Response type hydrogel drug loading system and preparation method and application thereof |
| CN115317661A (en) * | 2022-08-29 | 2022-11-11 | 北京化工大学常州先进材料研究院 | Natural polymer composite hydrogel dressing |
| CN115770323A (en) * | 2022-12-22 | 2023-03-10 | 稳得希林(沈阳)生物科技有限公司 | Recombinant collagen gel dressing and preparation method and application thereof |
| WO2023231050A1 (en) * | 2022-05-30 | 2023-12-07 | 浙江大学 | Tough antibacterial hydrogel dressing and preparation method therefor |
| CN117860948A (en) * | 2024-03-12 | 2024-04-12 | 江西永通科技股份有限公司 | Medical composite functional antibacterial dressing and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480224A (en) * | 2002-07-26 | 2004-03-10 | 马来西亚核技术研究所 | Starch hydrogel |
| CN1482925A (en) * | 2000-12-27 | 2004-03-17 | ˹���հ����߹�˾ | Anhydrous, hydrophilic absorbent wound dressing |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
-
2010
- 2010-11-02 CN CN 201010528711 patent/CN101982202B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1482925A (en) * | 2000-12-27 | 2004-03-17 | ˹���հ����߹�˾ | Anhydrous, hydrophilic absorbent wound dressing |
| CN1480224A (en) * | 2002-07-26 | 2004-03-10 | 马来西亚核技术研究所 | Starch hydrogel |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
Non-Patent Citations (5)
| Title |
|---|
| DAFU WEI ET AL: "Structural characterization and antibacterial activity of oligoguanidine(polyhexamethylene guanidine hydrochloride)", 《MATERIALS SCIENCE AND ENGINEERING C》, vol. 29, 20 February 2009 (2009-02-20) * |
| KUNAL PAL ET AL: "Effect of heat treatment of starch on the properties of the starch hydrogels", 《MATERIALS LETTERS》, vol. 62, 17 May 2007 (2007-05-17) * |
| 尤春等: "PVA/壳聚糖/淀粉水凝胶的制备和性能", 《沈阳理工大学学报》, vol. 26, no. 4, 31 August 2007 (2007-08-31) * |
| 景欣欣等: "（键合胍盐低聚物的抗菌聚苯乙烯的制备及其抗菌活性", 《功能高分子学报》, vol. 23, no. 1, 31 March 2010 (2010-03-31) * |
| 潘国庆等: "羧甲基两性淀粉的制备及其在造纸中的应用", 《广西轻化工》, no. 5, 31 May 2007 (2007-05-31) * |
Cited By (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908648B (en) * | 2012-10-24 | 2014-01-15 | 合肥工业大学 | Gel type paeonol air freshener |
| CN102908648A (en) * | 2012-10-24 | 2013-02-06 | 合肥工业大学 | Gel type paeonol air freshener |
| CN105496566A (en) * | 2015-12-14 | 2016-04-20 | 清华大学 | Medical multi-layer composite anti-adhesion membrane and preparation method thereof |
| CN105496566B (en) * | 2015-12-14 | 2018-07-13 | 清华大学 | A kind of medical multilayer compound anti-adhesion film and preparation method thereof |
| CN105597143A (en) * | 2016-02-01 | 2016-05-25 | 山东省药学科学院 | Method for preparing styptic powder by pure aqueous phase |
| CN105597143B (en) * | 2016-02-01 | 2018-12-18 | 山东省药学科学院 | A kind of method that pure water mutually prepares styptic powder |
| CN105920654A (en) * | 2016-04-27 | 2016-09-07 | 李明华 | Burn dressing applicable to department of burn and having antibacterial effect |
| CN106039395A (en) * | 2016-08-11 | 2016-10-26 | 潘忠宁 | Preparation method of bonded antibacterial hydrogel dressing |
| CN106620830A (en) * | 2016-12-09 | 2017-05-10 | 苏州纳贝通环境科技有限公司 | Medical tissue regeneration-promoting hydrogel dressing and preparation method thereof |
| CN108530652B (en) * | 2018-03-29 | 2021-08-10 | 钦州学院 | Modified starch composite gel and preparation method and application thereof |
| CN108530652A (en) * | 2018-03-29 | 2018-09-14 | 钦州学院 | A kind of converted starch plural gel and its preparation method and application |
| CN108478470A (en) * | 2018-04-24 | 2018-09-04 | 上海益好纳米科技有限公司 | A kind of carrier-free can absorb type gel mask and preparation method thereof |
| CN108424533A (en) * | 2018-05-30 | 2018-08-21 | 中国科学院兰州化学物理研究所 | A kind of 3D printing bio-medical hydrogel and preparation method thereof |
| CN110157019A (en) * | 2019-05-17 | 2019-08-23 | 韩建中 | A kind of PVA gelatine starch hydrogel preparation method |
| CN110330658A (en) * | 2019-06-14 | 2019-10-15 | 浙江工业大学 | A kind of sterilization, low bacterial adhesion, the anti-bacterial hydrogel of bacterium release and its preparation method and application |
| CN110330658B (en) * | 2019-06-14 | 2021-06-22 | 浙江工业大学 | Antibacterial hydrogel with functions of sterilization, low bacterial adhesion and bacterial release and preparation method and application thereof |
| CN110786989B (en) * | 2019-10-28 | 2021-06-11 | 安庆师范大学 | Preparation method of medical antibacterial gel dressing |
| CN110786989A (en) * | 2019-10-28 | 2020-02-14 | 安庆师范大学 | Preparation method of medical antibacterial gel dressing |
| CN111729123A (en) * | 2020-06-29 | 2020-10-02 | 苏州凝智新材料发展有限公司 | Suture-free hydrogel adhesive plaster for tissue wound closure and preparation method thereof |
| CN111870734A (en) * | 2020-08-19 | 2020-11-03 | 山东东贝医药科技有限公司 | Preparation method of medical antibacterial healing-promoting hydrogel dressing |
| CN112121225A (en) * | 2020-10-16 | 2020-12-25 | 广西大学 | Nanocomposite hydrogel for bleeding control and preparation method thereof |
| CN113058072A (en) * | 2021-03-16 | 2021-07-02 | 卫纳塞德(北京)医疗科技有限公司 | Antibacterial medical cold compress hydrogel and preparation method thereof |
| CN113058073A (en) * | 2021-03-16 | 2021-07-02 | 卫纳塞德(北京)医疗科技有限公司 | Cold compress type medical hydrogel and preparation method thereof |
| CN114272434A (en) * | 2021-03-16 | 2022-04-05 | 卫纳塞德(北京)医疗科技有限公司 | Degradable medical cold compress hydrogel and preparation method thereof |
| CN113244443A (en) * | 2021-04-28 | 2021-08-13 | 广州大学 | Hydrogel dressing and preparation method and application thereof |
| CN113136040A (en) * | 2021-05-08 | 2021-07-20 | 中国科学院华南植物园 | Cationic starch gel and preparation method and application thereof |
| CN114796502A (en) * | 2021-06-23 | 2022-07-29 | 四川大学华西医院 | Response type hydrogel drug loading system and preparation method and application thereof |
| CN114796502B (en) * | 2021-06-23 | 2023-08-15 | 四川大学华西医院 | Responsive hydrogel drug-loading system and preparation method and application thereof |
| CN114010836A (en) * | 2021-11-29 | 2022-02-08 | 深圳先进技术研究院 | Hemostatic dressing and preparation method thereof |
| CN114767933A (en) * | 2022-04-02 | 2022-07-22 | 伊索曼(中山)医疗器械有限公司 | Hydrogel and preparation method thereof |
| WO2023231050A1 (en) * | 2022-05-30 | 2023-12-07 | 浙江大学 | Tough antibacterial hydrogel dressing and preparation method therefor |
| CN115317661A (en) * | 2022-08-29 | 2022-11-11 | 北京化工大学常州先进材料研究院 | Natural polymer composite hydrogel dressing |
| CN115770323A (en) * | 2022-12-22 | 2023-03-10 | 稳得希林(沈阳)生物科技有限公司 | Recombinant collagen gel dressing and preparation method and application thereof |
| CN115770323B (en) * | 2022-12-22 | 2024-01-16 | 稳得希林(沈阳)生物科技有限公司 | Recombinant collagen gel dressing and preparation method and application thereof |
| CN117860948A (en) * | 2024-03-12 | 2024-04-12 | 江西永通科技股份有限公司 | Medical composite functional antibacterial dressing and preparation method thereof |
| CN117860948B (en) * | 2024-03-12 | 2024-06-04 | 江西永通科技股份有限公司 | Medical composite functional antibacterial dressing and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101982202B (en) | 2013-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101982202B (en) | Medical hydrogel dressings and preparation method thereof | |
| CN106492260B (en) | Alginate-based hydrogel dressing and preparation method thereof | |
| CN1320931C (en) | Dressing material containing medicine chitoholosida and its preparation method | |
| CN108014366B (en) | Marine biological material composite hydrogel dressing and preparation method thereof | |
| CN103083713B (en) | A kind of aseptic polymerization wound-surface cover dressing | |
| Li et al. | An antibacterial bilayer hydrogel modified by tannic acid with oxidation resistance and adhesiveness to accelerate wound repair | |
| Yuan et al. | Chitosan, alginate, hyaluronic acid and other novel multifunctional hydrogel dressings for wound healing: A review | |
| CN103520767A (en) | Anti-microbial healing-promoting hydrogel dressing and preparation method therefor | |
| CN101502667B (en) | Medical chitosan transparent hydrogel wound dressing as well as preparation and application thereof | |
| Lu et al. | Construction and function of robust and moist bilayer chitosan-based hydrogel wound dressing | |
| Lima et al. | Skin wounds, the healing process, and hydrogel-based wound dressings: a short review | |
| CN103480033B (en) | A kind of medical bio polysaccharide hemostasia and healing sponge and preparation method thereof | |
| CN103463669A (en) | Liquid wound dressing and preparation method thereof | |
| CN107349459B (en) | A kind of glucan base hemostatic and antibacterial promoting healing material and preparation method thereof | |
| BRPI0613606A2 (en) | biomaterials in the form of non-woven felts, processes for their preparation and use and fibers | |
| CN102552966A (en) | Alginate antibacterial dressing and its preparation method | |
| CN105012993A (en) | Medical and antibacterial cationic biogel dressing and preparation method thereof | |
| Kibungu et al. | This review recent advances in chitosan and alginate‐based hydrogels for wound healing application | |
| CN101518481B (en) | Medical moisturized eye paste and method for preparing same | |
| Xie et al. | Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose‑sodium alginate composite sponges for accelerated wound healing | |
| Singh et al. | Application of tragacanth gum and alginate in hydrogel wound dressing's formation using gamma radiation | |
| CN105833331A (en) | Preparation method for degradable biological wound dressing and obtained product | |
| CN109432481A (en) | A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof | |
| CN109331215A (en) | A kind of medical antibacterial sponge and preparation method thereof | |
| CN111481735A (en) | Medical antibacterial wound-protecting hydrogel dressing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130918 |