CN110157019A - A kind of PVA gelatine starch hydrogel preparation method - Google Patents
A kind of PVA gelatine starch hydrogel preparation method Download PDFInfo
- Publication number
- CN110157019A CN110157019A CN201910414109.2A CN201910414109A CN110157019A CN 110157019 A CN110157019 A CN 110157019A CN 201910414109 A CN201910414109 A CN 201910414109A CN 110157019 A CN110157019 A CN 110157019A
- Authority
- CN
- China
- Prior art keywords
- starch
- pva
- hydrogel
- stirring
- quantitative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
- C08J2329/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2403/00—Characterised by the use of starch, amylose or amylopectin or of their derivatives or degradation products
- C08J2403/02—Starch; Degradation products thereof, e.g. dextrin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2429/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2429/02—Homopolymers or copolymers of unsaturated alcohols
- C08J2429/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2489/00—Characterised by the use of proteins; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of PVA gelatine starch hydrogel preparation methods, it includes: polyvinyl alcohol, gelatin, starch that the hydrogel, which prepares raw material, the hydrogel the preparation method is as follows: S1, weigh quantitative polyvinyl alcohol using electronic scale, put into flask；Quantitative distilled water is added into flask, is then heated to 85 DEG C, 1.5h is stirred with the rate of 150r/min, is configured to the PVA solution that mass fraction is 10%；S2, it quantitative starch is added after PVA solution is completely dissolved is mixed, continuous heating and stirring, 0.5h is heated, for the present invention by polyvinyl alcohol, starch and the common synthetic hydrogel of gelatin, the structure and performance of the macromolecule hydrogel of synthesis can finely regulatings, and it is reproducible, easy to process, mechanical property is preferable, and plasticity is strong, with lesser dehydration property and lesser swelling ratio, stability is high.
Description
Technical field
The present invention relates to bio-ink field more particularly to a kind of PVA gelatine starch hydrogel preparation methods.
Background technique
Pharmaceutical grade Polyethylene alcohol is different from chemical industry rank polyvinyl alcohol, it is a kind of extremely safe macromolecule organic, right
Human body is nontoxic, without side-effects, have good biocompatibility, especially in medical treatment if its aqueous gel is in ophthalmology, wound
Being widely used in terms of dressing and joint prosthesis, while in polyvinyl alcohol film in medicinal film, artificial kidney film etc. also has
It uses.
Gelatin (Gelatin), the structure that do not fix and relative molecular weight, by animal skin, bone, sarolemma, flesh evil spirit etc.
Collagenous portion in connective tissue degrades and becomes white or faint yellow, translucent, micro-strip gloss thin slice or powder;It is a kind of
Colorless and odorless, non-volatility, transparent hard non-crystalline material, dissolves in hot water, does not dissolve in cold water, but it is swollen slowly to absorb water
Swollen softening, the absorbable water for being equivalent to 5-10 times of weight of gelatin.
Natural polymer hydrogel cellular affinity is preferable, but since material source is different, the difference between batches of materials is bright
Aobvious, material property poor repeatability, mechanical property is difficult to meet the medical requirement under different condition, processing difficulties, poor mechanical property,
Poor plasticity, therefore, it is proposed that a kind of PVA gelatine starch hydrogel preparation method.
Summary of the invention
The purpose of the present invention is to provide a kind of PVA gelatine starch hydrogel preparation methods, solve institute in background technique
The problem of proposition.
To achieve the above object, the invention provides the following technical scheme: a kind of PVA gelatine starch hydrogel preparation method,
It includes: polyvinyl alcohol, gelatin, starch that the hydrogel, which prepares raw material, the hydrogel the preparation method is as follows:
S1, quantitative polyvinyl alcohol is weighed using electronic scale, put into flask；Quantitative distilled water is added into flask,
85 DEG C are then heated to, 1.5h is stirred with the rate of 150r/min, is configured to the PVA solution that mass fraction is 10%；
S2, it quantitative starch is added after PVA solution is completely dissolved is mixed, 0.5h is heated in continuous heating and stirring；
S3, after starch all dissolves, gelatin continuous heating and stirring is added, stirring exists to grainless object in solution, stops
It only stirs and cools the temperature to 40 DEG C, heat preservation 10min；
S4, deaeration processing is then carried out, mixed solution is poured on aluminium sheet, casting film-forming, squeezes and be sealed；
S5, it is put into progress freeze-thaw technique in low temperature thermostat bath.
As a kind of preferred embodiment of the invention, the freeze-thaw process flow are as follows: room temperature drops to -20 DEG C, protects
Warm 2h, being then warming up to incubation at room temperature 2h again is a circulation, and 6 circulations are repeated.
As a kind of preferred embodiment of the invention, the temperature and revolving speed of continuous heating and stirring in the S2 and S3
It is 85 DEG C and 150r/min.
As a kind of preferred embodiment of the invention, the alcoholysis degree of the polyvinyl alcohol is 99%.
As a kind of preferred embodiment of the invention, the mass ratio of the starch and polyvinyl alcohol is 1:5.
Compared with prior art, beneficial effects of the present invention are as follows:
1. PVA gelatine starch hydrogel preparation method of the invention, synthesizes water-setting by polyvinyl alcohol, starch and gelatin jointly
Glue, the structure and performance of the macromolecule hydrogel of synthesis can finely regulating, and reproducible, easy to process, mechanical property is preferable,
Plasticity is strong, has lesser dehydration property and lesser swelling ratio, and stability is high.
Specific embodiment
To be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, below with reference to
Specific embodiment, the present invention is further explained.
Embodiment one
Electronic scale weighs quantitative polyvinyl alcohol, is put into flask；Quantitative distilled water is added into flask, then plus
Heat is stirred 1.5h to 85 DEG C, with the rate of 150r/min, is configured to the PVA solution that mass fraction is 10%, works as PVA solution
Quantitative starch is added after being completely dissolved to be mixed, continuous heating and stirring, heats 0.5h, starch all after dissolution, is added
Gelatin continuous heating and stirring, stirring to grainless object in solution exist, and stop stirring and cooling the temperature to 40 DEG C, heat preservation
Then 10min carries out deaeration processing, mixed solution is poured on aluminium sheet so that gelatin and polyvinyl alcohol mass ratio are 1:1,
Casting film-forming is squeezed and is sealed, and is put into low temperature thermostat bath and is carried out freeze-thaw technique, and room temperature drops to -20 DEG C, keeps the temperature 2h,
Then being warming up to incubation at room temperature 2h again is a circulation, and 6 circulations are repeated.
Embodiment two
Electronic scale weighs quantitative polyvinyl alcohol, is put into flask；Quantitative distilled water is added into flask, then plus
Heat is stirred 1.5h to 85 DEG C, with the rate of 150r/min, is configured to the PVA solution that mass fraction is 10%, works as PVA solution
Quantitative starch is added after being completely dissolved to be mixed, continuous heating and stirring, heats 0.5h, starch all after dissolution, is added
Gelatin continuous heating and stirring, stirring to grainless object in solution exist, and stop stirring and cooling the temperature to 40 DEG C, heat preservation
Then 10min carries out deaeration processing, mixed solution is poured on aluminium sheet so that gelatin and polyvinyl alcohol mass ratio are 3:1,
Casting film-forming is squeezed and is sealed, and is put into low temperature thermostat bath and is carried out freeze-thaw technique, and room temperature drops to -20 DEG C, keeps the temperature 2h,
Then being warming up to incubation at room temperature 2h again is a circulation, and 6 circulations are repeated.
Embodiment three
Electronic scale weighs quantitative polyvinyl alcohol, is put into flask；Quantitative distilled water is added into flask, then plus
Heat is stirred 1.5h to 85 DEG C, with the rate of 150r/min, is configured to the PVA solution that mass fraction is 10%, works as PVA solution
Quantitative starch is added after being completely dissolved to be mixed, continuous heating and stirring, heats 0.5h, starch all after dissolution, is added
Gelatin continuous heating and stirring, stirring to grainless object in solution exist, and stop stirring and cooling the temperature to 40 DEG C, heat preservation
Then 10min carries out deaeration processing, mixed solution is poured on aluminium sheet so that gelatin and polyvinyl alcohol mass ratio are 6:1,
Casting film-forming is squeezed and is sealed, and is put into low temperature thermostat bath and is carried out freeze-thaw technique, and room temperature drops to -20 DEG C, keeps the temperature 2h,
Then being warming up to incubation at room temperature 2h again is a circulation, and 6 circulations are repeated.
Example IV
Electronic scale weighs quantitative polyvinyl alcohol, is put into flask；Quantitative distilled water is added into flask, then plus
Heat is stirred 1.5h to 85 DEG C, with the rate of 150r/min, is configured to the PVA solution that mass fraction is 10%, works as PVA solution
Quantitative starch is added after being completely dissolved to be mixed, continuous heating and stirring, heats 0.5h, starch all after dissolution, is added
Gelatin continuous heating and stirring, stirring to grainless object in solution exist, and stop stirring and cooling the temperature to 40 DEG C, heat preservation
Then 10min carries out deaeration processing, mixed solution is poured on aluminium sheet so that gelatin and polyvinyl alcohol mass ratio are 9:1,
Casting film-forming is squeezed and is sealed, and is put into low temperature thermostat bath and is carried out freeze-thaw technique, and room temperature drops to -20 DEG C, keeps the temperature 2h,
Then being warming up to incubation at room temperature 2h again is a circulation, and 6 circulations are repeated.
In conclusion the dehydration rate and swellbility of the hydrogel matched in example IV, show higher stability.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (5)
1. a kind of PVA gelatine starch hydrogel preparation method, it is characterised in that: it includes: polyethylene that the hydrogel, which prepares raw material,
Alcohol, gelatin, starch, the hydrogel the preparation method is as follows:
S1, quantitative polyvinyl alcohol is weighed using electronic scale, put into flask；Quantitative distilled water is added into flask,
85 DEG C are then heated to, 1.5h is stirred with the rate of 150r/min, is configured to the PVA solution that mass fraction is 10%；
S2, it quantitative starch is added after PVA solution is completely dissolved is mixed, 0.5h is heated in continuous heating and stirring；
S3, after starch all dissolves, gelatin continuous heating and stirring is added, stirring exists to grainless object in solution, stops
It only stirs and cools the temperature to 40 DEG C, heat preservation 10min.
S4, deaeration processing is then carried out, mixed solution is poured on aluminium sheet, casting film-forming, squeezes and be sealed；
S5, it is put into progress freeze-thaw technique in low temperature thermostat bath.
2. a kind of PVA gelatine starch hydrogel preparation method according to claim 1, it is characterised in that: the freezing solution
Freeze process flow are as follows: room temperature drops to -20 DEG C, keeps the temperature 2h, and being then warming up to incubation at room temperature 2h again is a circulation, is repeated 6
Secondary circulation.
3. a kind of PVA gelatine starch hydrogel preparation method according to claim 1, it is characterised in that: the S2 and S3
The temperature and revolving speed of middle continuous heating and stirring are 85 DEG C and 150r/min.
4. a kind of PVA gelatine starch hydrogel preparation method according to claim 1, it is characterised in that: the polyethylene
The alcoholysis degree of alcohol is 99%.
5. a kind of PVA gelatine starch hydrogel preparation method according to claim 1, it is characterised in that: the shallow lake
The mass ratio of powder and polyvinyl alcohol is 1:5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910414109.2A CN110157019A (en) | 2019-05-17 | 2019-05-17 | A kind of PVA gelatine starch hydrogel preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910414109.2A CN110157019A (en) | 2019-05-17 | 2019-05-17 | A kind of PVA gelatine starch hydrogel preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110157019A true CN110157019A (en) | 2019-08-23 |
Family
ID=67631072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910414109.2A Pending CN110157019A (en) | 2019-05-17 | 2019-05-17 | A kind of PVA gelatine starch hydrogel preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110157019A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114133750A (en) * | 2021-12-13 | 2022-03-04 | 武汉锐致科技有限公司 | Biodegradable secondary-throwing protection sealing sleeve/cap and preparation method thereof |
| CN114561076A (en) * | 2022-03-08 | 2022-05-31 | 韩建中 | Polyvinyl alcohol gelatin starch hydrogel and preparation method thereof |
| CN115895049A (en) * | 2022-11-08 | 2023-04-04 | 北京林业大学 | Fiber-reinforced crosslinked aerogel buffer material and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101982202A (en) * | 2010-11-02 | 2011-03-02 | 华东理工大学 | Medical hydrogel dressings and preparation method thereof |
| CN107602878A (en) * | 2017-10-09 | 2018-01-19 | 常州凯途纺织品有限公司 | A kind of preparation method of polyvinyl alcohol hydrogel |
-
2019
- 2019-05-17 CN CN201910414109.2A patent/CN110157019A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101982202A (en) * | 2010-11-02 | 2011-03-02 | 华东理工大学 | Medical hydrogel dressings and preparation method thereof |
| CN107602878A (en) * | 2017-10-09 | 2018-01-19 | 常州凯途纺织品有限公司 | A kind of preparation method of polyvinyl alcohol hydrogel |
Non-Patent Citations (2)
| Title |
|---|
| Y.LIU ET AL.: ""Physically Crosslinked Composite Hydrogels of PVA With Natural Macromolecules: Structure, Mechanical Properties, and Endothelial Cell Compatibility"", 《JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS》 * |
| 尤春 等: ""PVA/明胶/淀粉水凝胶的制备及性能"", 《塑料工业》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114133750A (en) * | 2021-12-13 | 2022-03-04 | 武汉锐致科技有限公司 | Biodegradable secondary-throwing protection sealing sleeve/cap and preparation method thereof |
| CN114561076A (en) * | 2022-03-08 | 2022-05-31 | 韩建中 | Polyvinyl alcohol gelatin starch hydrogel and preparation method thereof |
| CN114561076B (en) * | 2022-03-08 | 2023-09-26 | 韩建中 | Polyvinyl alcohol gelatin starch hydrogel and preparation method thereof |
| CN115895049A (en) * | 2022-11-08 | 2023-04-04 | 北京林业大学 | Fiber-reinforced crosslinked aerogel buffer material and preparation method thereof |
| CN115895049B (en) * | 2022-11-08 | 2024-01-26 | 北京林业大学 | Fiber-reinforced crosslinked aerogel buffer material and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110157019A (en) | A kind of PVA gelatine starch hydrogel preparation method | |
| WO2007003113A1 (en) | A composition of raw materials for a plant polyose-containing hollow capsule and the properation method of such capsure | |
| US3706631A (en) | Sterilization of protein-containing fluids | |
| CN107550764A (en) | A kind of preparation method of the oil and fat of sacha inchi water profit Q hoodles of high stability | |
| CN102362853B (en) | Genipin cross-linked soybean protein based theophylline controlled-release gel preparation and preparation method thereof | |
| CN105327382B (en) | The method that double cross connection method prepares medical transparent polyethylene alcohol hydrogel | |
| CN109251451A (en) | A kind of preparation method of pH responsive type xanthan gum/polyvinyl alcohol hydrogel | |
| CN106166143A (en) | A kind of plant hollow and hard capsule shell material and preparation method thereof | |
| CN113429589A (en) | Glycyrrhetinic acid-based pH-sensitive slow-release hydrogel material and preparation method and application thereof | |
| CN104844810A (en) | Pulullan-human-like collagen hydrogel and preparation method thereof | |
| CN109481339B (en) | Collagen-based composite hydrogel surface film material and preparation method and application thereof | |
| CN108030953A (en) | A kind of medical use hydrocolloid dressing and preparation method thereof | |
| WO2020073592A1 (en) | Pullulan empty hard capsule and preparation method therefor | |
| CN102350009A (en) | Preparation method of composite bone matrix gelatin polylactic acid porous bioactive material | |
| RU2089198C1 (en) | Method of preparing biomaterial for using in ophthalmology | |
| CN107759711B (en) | Epoxy chitosan quaternary ammonium salt and preparation method thereof | |
| CN110511405A (en) | A kind of antimicrobial form keratin based aquagel and preparation method thereof | |
| JP2001008634A (en) | Soluble polymerized gelatin, its production and method for adjusting its solubility | |
| JPH10310519A (en) | Capsule | |
| CN105616323A (en) | Silk sponge product for nourishing and caring skin and preparation method thereof | |
| CN109453078B (en) | Bionic matrix hydrogel mask and preparation method thereof | |
| JPS61152247A (en) | Production of protein membrane | |
| US5936256A (en) | Method of preparing a biological material for use in ophthalmology | |
| CN112336698A (en) | Rapidly disintegrating vaginal soft capsule composition and preparation method thereof | |
| CN101716185B (en) | Anti-adhesion agent and preparation process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190823 |