CN111407791A - External traditional Chinese medicine care solution for promoting wound healing - Google Patents

Abstract

The invention discloses an external traditional Chinese medicine care solution for promoting wound healing, which is prepared from the following traditional Chinese medicinal materials in parts by weight: 15-45 parts of astragalus membranaceus, 12-25 parts of pomegranate rind, 5-25 parts of gorse flabellatus, 5-20 parts of abelmoschus manihot, 10 parts of copper cash, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The external traditional Chinese medicine care solution has the effects of resisting bacteria, diminishing inflammation, astringing to stop bleeding, removing putrefaction, promoting granulation and the like under the synergistic cooperation of the medicinal materials, and integrally adjusts the level of wound surface epidermal growth factors, so that the wound surface is promoted to heal quickly.

Description

External traditional Chinese medicine care solution for promoting wound healing

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external traditional Chinese medicine care solution for promoting wound healing.

Background

The skin is the first barrier of the body to the outside world, and can prevent the invasion of bacteria, viruses and the like, but when the skin is damaged to form wounds, the human body or other animals can be invaded by the bacteria and the viruses. The wound is treated correctly and can heal rapidly, otherwise, the wound can be suppurative and infected for a long time and even complicated with systemic infection, gas gangrene, tetanus and the like which endanger life. Clinically, skin injuries caused by various reasons are common diseases and high morbidity, and scars formed after the wounds bring huge damage to the physiology and the psychology of patients. At present, common medicines for disinfecting and debriding skin comprise medical alcohol, diluted iodine tincture, iodophor, furacilin solution, benzalkonium bromide solution and the like, but clinical application finds that the medicines have strong irritation, cannot be applied in a large area, have unsatisfactory debridement effect and even have anaphylactic reaction. In addition, the medicines have no functions of promoting granulation growth, easing pain and the like, basically stay in the stage of waiting for the natural healing of the wound surface, and have very limited effect of promoting the healing of the wound surface. Some medicines contain some growth factors, although the growth factors have stronger cell proliferation promoting effect and can promote wound healing, the safety of the medicines is always the focus of attention of people because the wound healing needs a plurality of growth factors, the compatibility is complex, and the excessive proliferation of the cells can form proliferative scars and even cause canceration. Some medicines mainly take antibiotic treatment medicines, and the excessive use of the antibiotic medicines can easily cause pathogenic bacteria to generate drug resistance and reduce human immunity.

With the importance of Chinese medicine and the continuous acceleration of social rhythm, more people like or choose the method of external treatment of Chinese medicine to treat diseases or to keep health, and the Chinese medicine has the advantages of simplicity, convenience, low price, safety, reliability, quick curative effect, easy popularization and the like. Natural medicines are an important source for finding new medicines at present, and have attracted wide attention of all countries in the world; the Chinese medicine is an important component of the Chinese medicine and is also an advantageous field of new medicine development in China. The traditional Chinese medicine is externally used for promoting wound healing, has unique curative effect, takes 'pus accretion per nestle', 'removing putrefaction and promoting tissue regeneration', 'promoting blood circulation and removing blood stasis' as main treatment principles, plays a multi-target, multi-link and multi-level comprehensive regulation and control role aiming at main influencing factors of wound healing, improves the curative effect of the medicine, reduces adverse reactions and reduces the medication cost. At present, a plurality of traditional Chinese medicine preparations for promoting the healing of skin wounds have been developed successively at home and abroad, but the traditional Chinese medicine preparations for promoting the healing of the wounds have advantages and have defects of different degrees, so that the field needs to further research and develop a novel external traditional Chinese medicine nursing liquid which has good effect on promoting the healing of the skin wounds, simple preparation process, low cost, and outstanding antibacterial, anti-inflammatory, astringent, hemostatic, putrefaction-removing, granulation-promoting and granulation-promoting effects.

Disclosure of Invention

The invention aims to provide an external traditional Chinese medicine care solution for promoting wound healing, which has the effects of resisting bacteria, diminishing inflammation, astringing to stop bleeding, removing putrefaction, promoting granulation growth and the like under the synergistic cooperation of all medicinal materials, so that the level of wound surface epidermal growth factors is integrally increased, and the wound surface is promoted to heal quickly.

In order to achieve the purpose, the invention adopts the technical scheme that: an external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 15-45 parts of astragalus membranaceus, 12-25 parts of pomegranate rind, 5-25 parts of gorse flabellatus, 5-20 parts of abelmoschus manihot, 10 parts of copper cash, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol.

Preferably, the weight ratio of the astragalus to the pomegranate rind to the broom cypress to the abelmoschus manihot is as follows: pomegranate rind: broom cypress leaf: okra 2-3:1-2: 1.

preferably, the external traditional Chinese medicine care solution is prepared from the following traditional Chinese medicinal materials in parts by weight: 25 parts of astragalus membranaceus, 15 parts of pomegranate rind, 15 parts of sparrow's broom cypress, 12 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol.

The medicinal materials have the following properties and flavors:

astragalus root: has effects in enhancing immunity, inhibiting bacteria, invigorating qi, consolidating superficial resistance, arresting sweating, promoting granulation, inducing diuresis, and relieving swelling. Radix astragali Preparata has effects of invigorating qi, strengthening middle warmer, relieving exterior syndrome, promoting pus discharge, promoting urination, and promoting granulation, and can be used for treating qi deficiency, debilitation, chronic diarrhea, rectocele, spontaneous perspiration, edema, uterine prolapse, chronic nephritis proteinuria, diabetes, and unhealed wound. Astragalus membranaceus is produced in inner Mongolia, Shanxi, Gansu, Heilongjiang, Shaanxi, etc.

Pomegranate rind: has antibacterial, antidiarrheal, hemostatic, and anthelmintic effects. It is commonly used for chronic diarrhea, chronic dysentery, hematochezia, rectocele, metrorrhagia, leukorrhagia, abdominal pain due to parasitic infestation.

The sparrow's broom has mild nature and taste, has the effects of stopping bleeding, diminishing inflammation, resisting bacteria, eliminating free radicals and the like, is rich in antioxidant (SOD) components, can slow down oxidation, is beneficial to maintaining human health, delaying aging and enhancing the immunological competence of a system. Although the medicinal curative effect of the gorse seniavinii is proved by folks, the utilization rate of the gorse seniavinii is low at present, only a small amount of flowers are picked in the flowering phase as the raw materials of the traditional Chinese medicine, and a large amount of flowers are not treated by people after falling to the ground or are naturally lost after withering, so that the precious wild edible flower resources are wasted.

Yellow sunflower: slightly sweet and cold. Clear heat and remove toxicity, promote lactation and relax bowels. Can be used for treating hyperpyrexia, cough due to lung heat, dysentery, constipation, puerperal galactostasis, fracture, carbuncle, sore, abscess, undefined lump, and scald due to water and fire.

Herba lysimachiae: pungent and bitter in flavor and cool in nature. It enters gallbladder, liver, kidney and bladder meridians. Can clear away damp-heat, relieve stranguria and reduce swelling. Mainly used for treating heat stranguria, stranguria caused by sand, unsmooth and painful urination, jaundice and dark urine, carbuncle, swelling, furuncle and venomous snake bite; calculus of liver and gallbladder, and lithangiuria.

Folium artemisiae argyi: pungent, bitter and warm in nature; has little toxicity. The whole herb is used as a medicine and has the functions of warming channels, removing dampness, dispelling cold, stopping bleeding, diminishing inflammation, relieving asthma, relieving cough, preventing miscarriage, resisting allergy and the like.

Myrrh: can be used for treating traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Borneol: pungent and bitter with slight cold flavor, enter heart, spleen and lung meridians, and have the effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain. The borneol mainly contains borneol, has antibacterial and anti-inflammatory effects, and can relieve pain and promote transdermal absorption of other medicines.

The raw materials are plant effective parts including roots, stems, leaves, flowers and/or fruits or extracts thereof.

The care solution is a spray or a lotion.

Although the external traditional Chinese medicine care solution prepared by the conventional method can be used for preparing the external traditional Chinese medicine care solution, in order to obtain the effective ingredients of the traditional Chinese medicines to the maximum extent, the inventor optimizes the preparation method of the external traditional Chinese medicine care solution, and the preparation method comprises the following steps:

cleaning and drying astragalus, and grinding into fine powder respectively;

removing impurities from fresh maidenhair, pomegranate rind, abelmoschus manihot, folium artemisiae argyi and copper cash, purifying, draining, freezing at-18 ℃ for 5-10h respectively, drying at normal temperature in vacuum, and carrying out superfine grinding to obtain superfine powder; micronizing Borneolum Syntheticum to obtain superfine powder;

III, respectively adding the raw materials treated in the steps I and II into 4 times of ethanol solution by weight, and carrying out CO treatment at 40-50 ℃ under the pressure of 4.0MPa₂Performing supercritical extraction for 2 to 4 hours to obtain traditional Chinese medicine extraction liquid medicine, concentrating and drying the traditional Chinese medicine extraction liquid medicine into powder for later use;

and IV, weighing and mixing the Chinese medicinal powder obtained in the step III according to a weight ratio, adding the Chinese medicinal powder into deionized water of which the weight is 1000 times that of the Chinese medicinal powder, uniformly mixing, and filling to obtain the care solution.

Compared with the prior art, the invention has the beneficial effects that: (1) the formula of the wound care solution is optimized, multiple Chinese herbal medicines are selected and used together, the wound care solution has the effects of resisting bacteria, diminishing inflammation, astringing, stopping bleeding, removing putrefaction, promoting granulation and the like, and the level of wound surface epidermal growth factors is adjusted up on the whole, so that wound surface healing is promoted; (2) the invention compounds the pomegranate rind and the gorse lingua on the basis of the common trauma medicine raw materials of the astragalus, the folium artemisiae argyi, the myrrh, the borneol, the abelmoschus manihot and the cupramma, improves the antibacterial, hemostatic, anti-infection and other performances of the medicine, accelerates the falling of necrotic tissues, promotes the growth of granulation tissues, has obvious curative effect on promoting the healing of wounds, does not leave scars on the wound surfaces, is very suitable for the wounds such as common bruise, contusion, puncture, cutting and the like, and has low cost and good curative effect.

Detailed Description

The technical solutions of the present invention are described clearly and completely below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Through a large number of experiments, the inventor finds that the preparation method of the external traditional Chinese medicine care solution preferably comprises the following steps:

cleaning and drying astragalus, and grinding into fine powder respectively;

removing impurities from fresh maidenhair, pomegranate rind, abelmoschus manihot, folium artemisiae argyi and copper cash, purifying, draining, freezing at-18 ℃ for 5-10h respectively, drying at normal temperature in vacuum, and carrying out superfine grinding to obtain superfine powder; micronizing Borneolum Syntheticum to obtain superfine powder;

III, respectively adding the raw materials treated in the steps I and II into 4 times of ethanol solution by weight, and carrying out CO treatment at 40-50 ℃ under the pressure of 4.0MPa₂Supercritical extraction for 2-4 hours to obtainExtracting the Chinese medicinal liquid, concentrating, and drying to obtain powder;

and IV, weighing and mixing the Chinese medicinal powder obtained in the step III according to a weight ratio, adding the Chinese medicinal powder into deionized water of which the weight is 1000 times that of the Chinese medicinal powder, uniformly mixing, and filling to obtain the care solution.

The preparation method of the invention takes natural medicinal materials as raw materials, adopts a medicine extraction method of superfine grinding and supercritical extraction, increases the extraction rate of the medicine, and fully exerts the effects of antibiosis, antiphlogosis, hemostasis, analgesia, granulation promotion, granulation growth promotion, antioxidation and the like of the raw materials. The preparation method of the external traditional Chinese medicine nursing liquid is not further limited by the following embodiments of the invention, because the preparation method of the external traditional Chinese medicine nursing liquid belongs to the optimal preparation method of the invention, and the preparation methods have no influence on the efficacy of the product with the same formula and proportion.

Example 1

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 25 parts of astragalus membranaceus, 15 parts of pomegranate rind, 15 parts of sparrow's broom cypress, 12 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol.

The preparation method of the external traditional Chinese medicine care solution comprises the following steps:

cleaning and drying astragalus, and grinding into fine powder respectively;

removing impurities from the maidenhair, pomegranate rind, abelmoschus manihot, folium artemisiae argyi and copper cash, purifying, draining, freezing at-18 ℃ for 8 hours respectively, drying at normal temperature in vacuum, and performing superfine grinding to obtain superfine powder; micronizing Borneolum Syntheticum to obtain superfine powder;

III, respectively adding the raw materials treated in the steps I and II into 4 times of ethanol solution by weight, and carrying out CO treatment at the temperature of 45 ℃ and under the pressure of 4.0MPa₂Performing supercritical extraction for 3 hr to obtain Chinese medicinal extractive solution, concentrating, and drying to obtain powder;

and IV, weighing and mixing the Chinese medicinal powder obtained in the step III according to a weight ratio, adding the Chinese medicinal powder into deionized water of which the weight is 1000 times that of the Chinese medicinal powder, uniformly mixing, and filling to obtain the care solution.

Example 2

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 15 parts of astragalus membranaceus, 12 parts of pomegranate rind, 25 parts of sparrow's broom cypress, 20 parts of abelmoschus manihot, 10 parts of ramose palustris, 12 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The preparation method of the external traditional Chinese medicine care solution is the same as that of the example 1.

Example 3

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 15 parts of astragalus membranaceus, 20 parts of pomegranate rind, 20 parts of sparrow's broom cypress, 5 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The preparation method of the external traditional Chinese medicine care solution is the same as that of the example 1.

Example 4

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 15 parts of astragalus membranaceus, 25 parts of pomegranate rind, 10 parts of sparrow's broom cypress, 15 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The preparation method of the external traditional Chinese medicine care solution is the same as that of the example 1.

Example 5

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 25 parts of astragalus membranaceus, 15 parts of pomegranate rind, 20 parts of sparrow's broom cypress, 10 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The preparation method of the external traditional Chinese medicine care solution is the same as that of the example 1.

Example 6

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 25 parts of astragalus membranaceus, 20 parts of pomegranate rind, 20 parts of sparrow's broom cypress, 10 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The preparation method of the external traditional Chinese medicine care solution is the same as that of the example 1.

Example 7

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 45 parts of astragalus membranaceus, 10 parts of pomegranate rind, 10 parts of sparrow's broom cypress, 10 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The preparation method of the external traditional Chinese medicine care solution is the same as that of the example 1.

Comparative example 1

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 10 parts of astragalus membranaceus, 15 parts of pomegranate rind, 15 parts of sparrow's broom cypress, 12 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The preparation method of the external traditional Chinese medicine care solution is the same as that of the example 1.

Comparative example 2

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 55 parts of astragalus membranaceus, 12 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The difference between the comparative example and the example 1 is that the ingredients do not contain pomegranate rind and sparrow filiformis, the content of the pomegranate rind and the sparrow filiformis is replaced by the astragalus, and the preparation method of the care solution is unchanged.

Comparative example 3

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 40 parts of astragalus membranaceus, 15 parts of sparrow's broom cypress, 12 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The difference between the comparative example and the example 1 is that the ingredients do not contain pomegranate rind, the content of the pomegranate rind is replaced by the astragalus, and the preparation method of the care solution is not changed.

Comparative example 4

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 40 parts of astragalus membranaceus, 15 parts of pomegranate rind, 12 parts of abelmoschus manihot, 10 parts of copper cash, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The difference between the comparative example and the example 1 is that the ingredients do not contain sparrow leucomelas, the astragalus root is used for replacing the content of the sparrow leucomelas, and the preparation method of the care solution is not changed.

Comparative example 5

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 25 parts of astragalus membranaceus, 15 parts of sparrow's broom cypress, 12 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The difference between the comparative example and the example 1 is that the ingredients do not contain pomegranate rind, the content of the pomegranate rind is replaced by the maidenhair, and the preparation method of the care solution is not changed.

Comparative example 6

An external traditional Chinese medicine care solution for promoting wound healing is prepared from the following traditional Chinese medicinal materials in parts by weight: 25 parts of astragalus membranaceus, 30 parts of pomegranate rind, 12 parts of abelmoschus manihot, 10 parts of copper cash, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol. The difference between the comparative example and the example 1 is that the ingredients do not contain the sparrow crassipes, the content of the sparrow crassipes is replaced by the pomegranate rind, and the preparation method of the care solution is not changed.

Effect verification

The spray prepared from the above examples 1-7 and comparative examples 1-6 is tested for antibacterial, wound healing and scar reducing effects, and the effects of antibacterial, healing promotion, scar reduction and the like of the invention are analyzed.

First, antibacterial experiment

Taking slant cultures of staphylococcus aureus, escherichia coli and pseudomonas aeruginosa, respectively inoculating the slant cultures into a meat soup culture medium, culturing the slant cultures at 36.5 ℃ for 24 hours, respectively taking 0.5 ml of the slant cultures, concentrating the slant cultures into 13 plate culture media, respectively taking the same amount of the medicines prepared in the examples 1-7 and the comparative examples 1-6, and respectively dripping the medicines into the 13 plate culture media in equal amount; acting for 5 minutes to detect the sterilization rate; the results are shown in the following table:

as can be seen from the table above, the wound care solution prepared by the invention has good antibacterial effect. Compared with the prior art, the wound care solution prepared by the raw materials and the proportion of the raw materials has better antibacterial effect on most pathogenic bacteria than other care solutions.

Second, testing the hemostatic and healing promoting effects

Taking 156 healthy SD rats, randomly and evenly dividing into 13 groups, each group comprises 12 rats, performing pentobarbital anesthesia (30mg/kg), opening 1cm beside one side of back vertebral column, and performing full-layer skin excision with a sharp knife to form an area of 3cm²The wound surface is cut off from the circular full-thickness skin, and the skin at the symmetrical part on the opposite side is used as the normal self-contrast. The same amount of the external traditional Chinese medicine nursing liquid of examples 1 to 7 and comparative examples 1 to 6 was used for wound treatment three times a day. The dacron is thrown on the 3 rd and 7 th daysAnd (5) calculating the size of the wound surface by film drawing and calculating the healing rate of the wound surface. The results are as follows:

as can be seen from the above table, compared with the comparative examples, the embodiment of the invention has the advantages that the hemostasis speed is high, the wound healing rate in 3 rd and 7 th days is better than that in comparative examples 1-6, and particularly, the hemostasis and healing promotion effects of the embodiment 1 are optimal, so that the wound healing promotion effect of the invention is obvious.

In addition, 6 rats in example 1 and comparative examples 1-6 were selected at random on days 3 and 7 respectively and sacrificed by excessive anesthesia, granulation tissue at the wound margin boundary was cut off, expression of lysozyme was measured by S-P method, and in situ apoptosis was detected by Tunel-AP method.

Variation of the content of lysozyme (x. + -. s) for each group

As can be seen from the table, the lysozyme content of the rat wound surface of the example is larger on the 3 rd day, the lysozyme content of the wound surface of the comparative example is larger on the 7 th day, and the lysozyme content of the example 1 of the invention is higher than that of the comparative example on the 3 rd and 7 th days. The embodiment 1 has the advantages that the time for the lysozyme content is earlier than that of the comparative example group, and the embodiment shows that the macrophage activity and function are enhanced, the cell function is enhanced, the ruins cleaning effect is enhanced, and the debridement function is strong. The apoptosis index result shows that the apoptosis index of the rat wound apoptosis in the example 1 is the largest on the 3 rd day, the apoptosis index of the rat wound apoptosis in the example 1 group is obviously reduced on the 7 th day compared with the 7 th day, and the apoptosis index of the rat wound apoptosis in the comparative example is increased on the 7 th day. Therefore, the care solution provided by the embodiment of the invention has the effect of rapidly promoting local tissue cell apoptosis, particularly induces apoptosis of dying cells in a transition region between wound necrotic tissues and normal tissues, is beneficial to promoting shedding of the necrotic tissues, is beneficial to wound debridement and granulation tissue growth, and can promote skin wound healing.

The healing condition of the rest of the rats which are not killed is continuously observed, and by visual observation, no obvious bacterial infection condition is seen in 3 days after injury in the examples 1-7 of the invention, no fat liquefaction phenomenon exists, more than 90 percent of wound surfaces heal, and the wound surfaces are flat and have no dark color; comparative examples 2 and 6 had no obvious infection on the wound surface on day 3, but the wound surface healed for more than 7 days, and obvious scars remained after the wound surface healed; comparative examples 3, 4 and 5 no obvious infection of the wound surface on day 3, and wound surface healing was observed on day 10, and fine scars remained after wound surface healing; comparative example 1, small area of fat liquefaction occurred in the case of a small amount of bacterial infection on the wound surface on day 3, the wound surface healed on day 14, and fine scars remained after the wound surface healed.

It can be seen from this that: compared with the wound care solutions of comparative examples 1 to 6, the wound care solutions of examples 1 to 7 of the invention have higher hemostasis speed and wound recovery rate, better wound recovery condition and smoother healed wound surface. The wound sprays of examples 1 to 7 were also subjected to cytotoxicity, acute test, skin irritation, and sensitization test, and the results were: the spray has no potential cytotoxicity in cytotoxicity test, and has no adverse reaction in acute test, skin irritation test and skin sensitization test.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (6)

1. The external traditional Chinese medicine care solution for promoting wound healing is characterized by being prepared from the following traditional Chinese medicinal materials in parts by weight: 15-45 parts of astragalus membranaceus, 12-25 parts of pomegranate rind, 5-25 parts of gorse flabellatus, 5-20 parts of abelmoschus manihot, 10 parts of copper cash, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol.

2. The external traditional Chinese medicine care solution as claimed in claim 1, wherein the weight ratio of the astragalus membranaceus, the pomegranate rind, the gorgon fruit and the abelmoschus manihot is that the astragalus membranaceus: pomegranate rind: broom cypress leaf: okra 2-3:1-2: 1.

3. the external traditional Chinese medicine care solution as claimed in claim 1, which is prepared from the following traditional Chinese medicinal materials in parts by weight: 25 parts of astragalus membranaceus, 15 parts of pomegranate rind, 15 parts of sparrow's broom cypress, 12 parts of abelmoschus manihot, 10 parts of ramose palustris, 20 parts of folium artemisiae argyi, 10 parts of myrrh and 10 parts of borneol.

4. The topical traditional Chinese medicine care solution according to claim 1, wherein the raw material is a plant effective part including roots, stems, leaves, flowers and/or fruits, or an extract thereof.

5. The external traditional Chinese medicine care solution of claim 1, wherein the care solution is a spray or a lotion.

6. The method for preparing the external traditional Chinese medicine care solution as claimed in any one of claims 1 to 5, comprising the following steps:

cleaning and drying astragalus, and grinding into fine powder respectively;

removing impurities from fresh maidenhair, pomegranate rind, abelmoschus manihot, folium artemisiae argyi and copper cash, purifying, draining, freezing at-18 ℃ for 5-10h respectively, drying at normal temperature in vacuum, and carrying out superfine grinding to obtain superfine powder; micronizing Borneolum Syntheticum to obtain superfine powder;

III, respectively adding the raw materials treated in the steps I and II into 4 times of ethanol solution by weight, and carrying out CO treatment at 40-50 ℃ under the pressure of 4.0MPa₂Performing supercritical extraction for 2 to 4 hours to obtain traditional Chinese medicine extraction liquid medicine, concentrating and drying the traditional Chinese medicine extraction liquid medicine into powder for later use;

and IV, weighing and mixing the Chinese medicinal powder obtained in the step III according to a weight ratio, adding the Chinese medicinal powder into deionized water of which the weight is 1000 times that of the Chinese medicinal powder, uniformly mixing, and filling to obtain the care solution.