CN1947801A - Composite function liquid wound dressing and its use - Google Patents
Composite function liquid wound dressing and its use Download PDFInfo
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- CN1947801A CN1947801A CN 200610033349 CN200610033349A CN1947801A CN 1947801 A CN1947801 A CN 1947801A CN 200610033349 CN200610033349 CN 200610033349 CN 200610033349 A CN200610033349 A CN 200610033349A CN 1947801 A CN1947801 A CN 1947801A
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Abstract
A multifunctional liquid dressing for cleaning wound, fast haemostasis and filing, preventing infection and promoting healing is a liquid sol composed of the superfine inorganic superfine particles (0.01-20%) and the liquid medium (80-99.9%) consisting of water and disinfectant.
Description
Technical field
The present invention relates to a kind of wound dressing, especially a kind of composite function liquid wound dressing and uses thereof.Belong to the topical drug technical field.
Technical background
At present, be widely used in and handle and the adhesive bandage dressing of treatment wound carries with easy to use, be suitable for handling little wound, accepted widely and use.But there are many defectives in it: between pad of (1) adhesive bandage and the wound slit is arranged, can not waterproof, it is infected to advance dirt easily, cause healing time to prolong and cicatrix obvious.(2) adhesive-layer of adhesive bandage is airtight is attached on the wound periphery skin, and the wounded feels under the weather during use, with the passing of time also may cause skin allergy.(3) adhesive bandage with after when taking off, pad might cling wound, not only influences wound healing but also cause the wounded's misery.(4) shape of the adhesive bandage wound that is fit to surely not of uniform size is handled needs, and inconvenience is cured the wound.(5) adhesive bandage can not quick-acting haemostatic powder.(6) adhesive bandage does not possess the function of cleaning wound, and if wound during use easily causes infecting without suitable cleaning.(7) adhesive bandage anti-ultraviolet not, wound is subjected to ultraviolet radiation easily to cause the skin complexion changed.
In order to overcome the shortcoming that aforementioned adhesive bandage exists, people adopt various improvement schemes:
For example, publication number is the Chinese patent application of CN1294903A and CN1491627A, proposes to improve with the mode of preserving moisture to remove the shortcoming that following time easily clings wound behind the dressing paste.CN1170564A proposes zinc-calcium alginate fiber nonwoven fabric is used in the dressing, has anastalsis.CN1182578A adds the soluble fiber layer in wound pastes, be dissolved into pasty state behind the absorption blood and help hemostasis.CN1453008A discloses a kind of Chinese medicine adhesive bandage, just can stick and does not infect with the clear water back that simply cleans a wound.But CN1198921A and CN1528257A propose the adhesive bandage of debridement, are the subsidiary on the packaging sterilization cleaning articles for use that have.CN1666726A proposes additional ultraviolet blocking film on adhesive bandage, prevents wound healing delay and cutaneous pigmentation etc.CN1364646A and CN1395968A propose chitosan class I liquid I biological dressing, can protect wound, protect from infection, promote healing in wound nature film forming.CN1561966A discloses a kind of liquid bandage; be to be filmogen by Pioloform, polyvinyl acetal or chitin; with ethanol, acetone, glycerol, dibutyl ester etc. is solvent; add the paste that nanometer silver and Maifanitum powder mix; be coated on the wound and can form the water resisting protection film, the effect of have bactericidal, subsiding a swelling hemostasis, easing the pain.
These technical schemes can be gone to a certain extent from each side to solve existing problems, but up to the present do not proposed comprehensive solution as yet.
Summary of the invention
First purpose of the present invention is for a kind of composite function liquid wound dressing is provided, and has to clean wound, quick-acting haemostatic powder, water proof and breathe freely, protect from infection, promote the complex function that heals.
Second purpose of the present invention is in order to propose a kind of purposes of composite function liquid wound dressing.
First purpose of the present invention can reach by adopting following measure:
Composite function liquid wound dressing is characterized in that:
1) described dressing is the liquid colloidal sol with sterilizing function, and blood, the tissue of this colloidal sol and wound and can become gel after surrounding skin contacts has hemostasis and film forming function;
2) described colloidal sol is made of inorganic matter solid particle and liquid medium; Wherein, the content of inorganic matter solid particle is 0.01-20%, and the content of liquid medium is 80-99.9%;
3) described liquid medium is made of the solution of water or water and disinfectant; The content of disinfectant is 0-90%; Described inorganic matter solid particle can have sterilizing function;
First purpose of the present invention can also reach by adopting following measure:
The particle diameter of described inorganic matter solid particle is less than 100 nanometers; Can be titanium oxide, zinc oxide or silicon dioxide solid particle, also can be two kinds or above concurrent of titanium oxide, zinc oxide and silicon dioxide solid particle, also can be the concurrent of titanium oxide, zinc oxide or silicon dioxide solid particle and described concurrent thereof and aluminium oxide, ferrum oxide, copper oxide, silver oxide or silver-colored solid particle.
Described disinfectant can be the one matter of alcohol, acid, surfactant, salt etc., as ethanol, propanol, butanols, acetic acid, boric acid, bromo geramine, Sal or silver acetate etc., also can be two kinds or above compositions of described one matter; In the described disinfectant, the content of alcohol is 0-90%, and the content of acid is 0-6%, and the content of surfactant is 0-0.1%, and the content of salt is 0-5%.
Second purpose of the present invention can reach by adopting following measure:
The purposes of composite function liquid wound dressing is characterized in that:
1) can be with described dressing containers for medical use (as polypropylene or polyethylene can) packing, can be by standby mode or portable design container shapes and capacity, or Vessel Design is become smear type, ejection-type, drop type, curtain coating type and topple over form design containers such as type by the spreading mode;
2) at injured scene, can clean wound with cleanout fluid such as clear water earlier, follow described dressing coating, injection, drop or curtain coating on wound, perhaps wound be immersed a moment in the described dressing, described dressing is quick-acting haemostatic powder, disinfecting pain relieving, and forms the gel protecting film on the wound surface; If at the injured on-the-spot cleanout fluid that lacks for the moment, available described dressing cleans wound, so that in time handle wound and protect from infection.Therefore, described dressing is applicable to popular emergency care of trauma, both has been suitable for carrying and has handled open-air wound, is suitable for a kind of standby dressing as individual, family, army and all trades and professions emergency case again.
Second purpose of the present invention can also reach by adopting following measure:
Described dressing is filled in the various medical water absorption carriers, forms the hemostatic material that contains described dressing, can comprise sthptic sponge, styptic cotton, hemostasis cushion block, hemostatic gauze and hemostasis bandage etc., be used to the first aid of stopping blooding.
Described hemostatic material can be used containers for medical use (as polypropylene or polyethylene can) or packing bag for medical use (as polypropylene or polythene film bag) sealing packing, can can Vessel Design be become once to use formula or repeatedly use formula by standby mode or portable choosing and design containers kind, shape and size by occupation mode; At injured scene, relatively large when hemorrhage when wound, can promptly clean wound with cleanout fluid such as clear water, take out described hemostatic material then and pin, fill in or wrap up wound, quick-acting haemostatic powder and disinfecting pain relieving in advance, hospital treatment rapidly subsequently.If at the injured on-the-spot cleanout fluid that lacks for the moment, available described hemostatic material cleans wound, so that in time handle wound and protect from infection.Therefore, described hemostatic material is applicable to popular emergency care of trauma, both has been suitable for carrying and has handled open-air wound, is suitable for a kind of standby hemostatic material as individual, family, army and all trades and professions emergency case again.
Described dressing one of can be with the following method made:
1, with packing after the commercially available colloidal sol adjustment concentration that contains described inorganic matter solid particle.
2, adopt and evenly to sneak into packing after an amount of described disinfectant in the commercially available colloidal sol that contains described inorganic matter solid particle.
3, with the solation of commercially available described inorganic matter solid particle, direct packaging is perhaps evenly sneaked into packing after an amount of described disinfectant.
4, utilize the predecessor of synthetic described inorganic matter solid particle,, in building-up process, add described disinfectant in advance, make described colloidal sol, then packing by the sol-gel synthetic method.
5, utilize the predecessor of synthetic described inorganic matter solid particle,, in building-up process, generate described inorganic matter solid particle and described disinfectant simultaneously, make described colloidal sol, then packing by the sol-gel synthetic method.
6, described hemostatic material one of can be with the following method made:
1), with medical water absorption carrier as in the dressing as described in the immersions such as medical sponge, medical absorbent cotton, hospital gauze, medical bandage as described in be filled colloidal sol, pick up the back with containers for medical use (as polypropylene or polyethylene can) or packing bag for medical use (as polypropylene or polythene film bag) sealing packing.
2), with medical water absorption carrier such as medical sponge, medical absorbent cotton, hospital gauze, medical bandage etc. with containers for medical use (as polypropylene or polyethylene can) or packing bag for medical use (as polypropylene or polythene film bag) packing, add described dressing then to being filled sealing.
The present invention has following outstanding beneficial effect:
1, the present invention is a liquid form product, inorganic matter colloidal sol and disinfectant are scientifically combined, form to handle the liquid dressing of wound, the complex function that just has cleaning, quick-acting haemostatic powder, do not limit shape, water proof to breathe freely, protect from infection, promote to heal, reduce cicatrix, alleviate complexion changed, need not to peel off, can not sensitization.Can solve the problem that existing adhesive bandage exists comprehensively.
2, dressing of the present invention is to wound nonirritant and sensitization; The wounded does not have the difference sensation to protective film; Wound site can activity freely: reach the effect that no pain cures the wound.If lack cleanout fluid, described dressing can be used as cleanout fluid, so that in time handle wound and protect from infection in injured on-the-spot a period of time.Therefore, described dressing is applicable to popular emergency care of trauma, both has been suitable for carrying and has handled open-air wound, is suitable for a kind of standby dressing as individual, family, army and all trades and professions emergency case again.
3, with dressing processing of the present invention and treatment wound, can repeatedly apply in case of necessity, described dressing forms protective film in coating place, has the effect of protecting wound, water proof to breathe freely, protect from infection, promote to heal, reduce cicatrix and alleviate the skin complexion changed.Need not to peel off protective film during this time, after recovering from injury, the protective film on the wound comes off with crust, and surplus person cleans with clear water and gets final product.
The specific embodiment:
Specific embodiment 1:
2% titanium oxide sol, dehydrated alcohol and glacial acetic acid are fully mixed in agitator according to 35: 85: 2 weight ratio, leave standstill, make dressing, standby with polypropylene or polyethylene can packing.
The granularity of described titanium oxide is the 30-40 nanometer.
Described titanium oxide sol replaceable one-tenth zinc oxide colloidal sol or silicon dioxide gel.
Specific embodiment 2:
Glacial acetic acid in the specific embodiment 1 is changed into 36% acetum, feed intake at 30: 70: 3 according to weight ratio, all the other are with specific embodiment 1.
Specific embodiment 3:
The granularity of titanium oxide is changed into the 3-10 nanometer, and all the other are with specific embodiment 1-2.
Specific embodiment 4:
Replace precedent 2% titanium oxide sol with 1% titanium oxide sol, all the other are with specific embodiment 1-3.
Specific embodiment 5:
3% titanium oxide sol, dehydrated alcohol and 10% boric acid solution are fully mixed in agitator with 10: 20: 7 weight ratio, leave standstill, make dressing, standby with polypropylene or polyethylene can packing.
The granularity of described titanium oxide is the 80-100 nanometer.
Specific embodiment 6:
Medical water absorption carriers such as medical absorbent cotton, sponge are immersed moments later pull out in the prepared dressing of described specific embodiment 1-5, make hemostatic material, standby with polypropylene or the packing of polyethylene sealing bag.
Specific embodiment 6:
Medical water absorption carriers such as medical absorbent cotton, sponge with polypropylene or polyethylene can packing, are added the prepared dressing of an amount of described specific embodiment 1-4 in container, make hemostatic material, seal standby then.
The component of described dressing has following effect:
Described inorganic solid particle can form colloidal sol under proper condition.Described colloidal sol is solid particle the dispersion system in liquid medium (as aqueous medium) of particle diameter less than 100 nanometers.Under certain conditions, suitable as concentration, when pH value is suitable, temperature is suitable etc., sol system is stable, and solid particle form with individual particles in liquid medium is disperseed, so colloidal sol shows as liquid state.When condition changed, it is unstable that colloidal sol might become, and attracts each other between the solid particle and crosslinked action, produces flocculation or gel.Flocculation is meant the flocculent substance that separate the crosslinked back of reuniting of solid particle from liquid medium.That gel is meant is that the crosslinked back of solid particle produces, wherein be full of the three-dimensional netted aggregate of liquid medium, and outward appearance is for freezing the shape material.Become solid-state three-dimensional netted aggregate behind the gel drying.The solid particle that constitutes this three-dimensional netted aggregate is very little, can have a large amount of nano level holes in aggregate, and therefore, the thin film of aggregate formation is ventilative and waterproof thus.We find, inorganic matter colloidal sol as titanium oxide sol, is met blood and can be become gel rapidly, promotes blood clotting, plays the effect of quick-acting haemostatic powder; Applying on wound and surrounding skin also can quick-gelatinizing, and dry postforming becomes ventilative water resisting protection thin film, plays the effect of isolating foul, protection wound surface, protect from infection, promote to heal and reduce cicatrix.Titanium oxide can be used as the Chinese white of coating, plastics, rubber, paper, food etc., also can be used as UV absorbent, is used for medical dressing and cosmetics, can also be used as catalyst etc.Zinc oxide can be used as the Chinese white of coating and the inserts of rubber, also can be used as medical dressing, can also be as the UV absorbent of cosmetics.Silicon dioxide is used to make glass, pottery, enamel, refractory material etc., also can be used as the filler of coating, plastics and rubber, can also be as the UV absorbent of cosmetics.In described dressing, use titanium oxide, zinc oxide or silicon dioxide gel, can anti-ultraviolet and alleviate wound skin complexion changed.
Disinfectant in the described dressing, as alcohol, acid, phenol, surfactant, salt etc., its solution has the sterilizing effect, wound capable of washing.For example, the alcoholic solution of 70-80% is usually used in skin degerming; The acetum of 0.5-2% is usually used in the wound surface washing; The boric acid solution of 2-5% is usually used in wound and cleans; Bubble hands before the 0.05% bromo geramine solution Rhizoma Atractylodis Macrocephalae commonly used; The sodium chloride solution of 0.5-5% is usually used in cleaning wound.
Claims (10)
1, composite function liquid wound dressing is characterized in that:
1) described dressing is the liquid colloidal sol with sterilizing function, and blood, the tissue of this colloidal sol and wound and can become gel after surrounding skin contacts has hemostasis and film forming function;
2) described colloidal sol is made of inorganic matter solid particle and liquid medium; Wherein, the content of inorganic matter solid particle is 0.01-20%, and the content of liquid medium is 80-99.9%;
3) described liquid medium is made of the solution of water or water and disinfectant; The content of disinfectant is 0-90%; Described inorganic matter solid particle can have sterilizing function.
2, according to the described composite function liquid wound dressing of claim 1, it is characterized in that: the particle diameter of aforementioned inorganic matter solid particle is less than 100 nanometers.
3, according to the described composite function liquid wound dressing of claim 1, it is characterized in that: aforementioned inorganic matter solid particle is titanium oxide, zinc oxide or silicon dioxide solid particle.
4, according to the described composite function liquid wound dressing of claim 1, it is characterized in that: aforementioned inorganic matter solid particle is two kinds or an above concurrent in titanium oxide, zinc oxide and the silicon dioxide solid particle.
5, according to the described composite function liquid wound dressing of claim 1, it is characterized in that: aforementioned inorganic matter solid particle is the concurrent of titanium oxide, zinc oxide or silicon dioxide solid particle and described concurrent and aluminium oxide, ferrum oxide, copper oxide, silver oxide or silver-colored solid particle.
6, according to the described composite function liquid wound dressing of claim 1, it is characterized in that: aforementioned disinfectant can be the one matter of alcohol, acid, surfactant or salt, comprises ethanol, propanol, butanols, acetic acid, boric acid, bromo geramine, Sal or silver acetate.
7, according to the described composite function liquid wound dressing of claim 6, it is characterized in that: aforementioned disinfectant is by two kinds or above compositions of described one matter; In the described disinfectant, the content of alcohol is 0-90%, and the content of acid is 0-6%, and the content of surfactant is 0-0.1%, and the content of salt is 0-5%.
8, the purposes of composite function liquid wound dressing according to claim 1 is characterized in that:
1) with described dressing containers for medical use packing, press standby mode or portable design container shapes and capacity, perhaps Vessel Design is become smear type, ejection-type, drop type, curtain coating type and topples over type form design containers by the spreading mode;
2) clean wound with cleanout fluid such as clear water earlier; follow described dressing coating, injection, drop or curtain coating on wound; perhaps wound is immersed a moment in the described dressing, described dressing is quick-acting haemostatic powder, disinfecting pain relieving, and forms the gel protecting film on the wound surface.
3) described dressing is used for popular emergency care of trauma, is used to carry the open-air wound of processing, perhaps a kind of standby dressing of conduct individual, family, army and all trades and professions emergency case.
9, the purposes of composite function liquid wound dressing according to claim 1, it is characterized in that: described dressing is filled in the various medical water absorption carriers, formation contains the hemostatic material of described dressing, can comprise sthptic sponge, styptic cotton, hemostasis cushion block, hemostatic gauze and hemostasis bandage, be used to the first aid of stopping blooding.
10, the purposes of composite function liquid wound dressing according to claim 9 is characterized in that:
1) described hemostatic material can seal packing with containers for medical use, can Vessel Design be become once to use formula or repeatedly use formula by standby mode or portable choosing and design containers kind, shape and size by occupation mode;
2) at injured scene, relatively large when hemorrhage when wound, can promptly clean wound with cleanout fluid such as clear water, take out described hemostatic material then and pin, fill in or wrap up wound, quick-acting haemostatic powder and disinfecting pain relieving in advance, hospital treatment rapidly subsequently; If at the injured on-the-spot cleanout fluid that lacks for the moment, available described hemostatic material cleans wound, so that in time handle wound and protect from infection;
3) described hemostatic material is used for popular emergency care of trauma, is used to carry the open-air wound of processing, perhaps a kind of standby hemostatic material of conduct individual, family, army and all trades and professions emergency case.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100333490A CN100522262C (en) | 2006-01-27 | 2006-01-27 | Composite function liquid wound dressing and its use |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100333490A CN100522262C (en) | 2006-01-27 | 2006-01-27 | Composite function liquid wound dressing and its use |
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| Publication Number | Publication Date |
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| CN1947801A true CN1947801A (en) | 2007-04-18 |
| CN100522262C CN100522262C (en) | 2009-08-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2006100333490A Expired - Fee Related CN100522262C (en) | 2006-01-27 | 2006-01-27 | Composite function liquid wound dressing and its use |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721734A (en) * | 2008-10-22 | 2010-06-09 | 威海威高创新有限公司 | Medical calcium alginate antiseptic dressing and preparation method thereof |
| CN104353105A (en) * | 2014-11-10 | 2015-02-18 | 苏州蔻美新材料有限公司 | Medical nano antibacterial gel material and preparation method thereof |
| CN104368032A (en) * | 2014-11-14 | 2015-02-25 | 苏州蔻美新材料有限公司 | Biologic gel material for wound repairing and preparation method of biologic gel material |
| CN105536039A (en) * | 2015-12-25 | 2016-05-04 | 北京大清生物技术有限公司 | Hemostatic material capable of absorbing fluid and preparation method and application thereof |
| CN108498841A (en) * | 2018-04-20 | 2018-09-07 | 苏州睿烁环境科技有限公司 | A kind of antibacterial anti hemorrhagic material and preparation method thereof that using effect is good |
| CN109331219A (en) * | 2018-11-30 | 2019-02-15 | 广州润虹医药科技股份有限公司 | A kind of chitosan liquid dressing |
| CN111359002A (en) * | 2020-04-28 | 2020-07-03 | 天津大学 | RuCu2Preparation method of O-shaped photothermal healing promoting band-aid |
-
2006
- 2006-01-27 CN CNB2006100333490A patent/CN100522262C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721734A (en) * | 2008-10-22 | 2010-06-09 | 威海威高创新有限公司 | Medical calcium alginate antiseptic dressing and preparation method thereof |
| CN104353105A (en) * | 2014-11-10 | 2015-02-18 | 苏州蔻美新材料有限公司 | Medical nano antibacterial gel material and preparation method thereof |
| CN104353105B (en) * | 2014-11-10 | 2017-02-01 | 启东欣荣旅游开发有限公司 | Medical nano antibacterial gel material and preparation method thereof |
| CN104368032A (en) * | 2014-11-14 | 2015-02-25 | 苏州蔻美新材料有限公司 | Biologic gel material for wound repairing and preparation method of biologic gel material |
| CN105536039A (en) * | 2015-12-25 | 2016-05-04 | 北京大清生物技术有限公司 | Hemostatic material capable of absorbing fluid and preparation method and application thereof |
| CN108498841A (en) * | 2018-04-20 | 2018-09-07 | 苏州睿烁环境科技有限公司 | A kind of antibacterial anti hemorrhagic material and preparation method thereof that using effect is good |
| CN109331219A (en) * | 2018-11-30 | 2019-02-15 | 广州润虹医药科技股份有限公司 | A kind of chitosan liquid dressing |
| CN111359002A (en) * | 2020-04-28 | 2020-07-03 | 天津大学 | RuCu2Preparation method of O-shaped photothermal healing promoting band-aid |
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| Publication number | Publication date |
|---|---|
| CN100522262C (en) | 2009-08-05 |
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Granted publication date: 20090805 Termination date: 20120127 |