KR20110114195A - Hydrogel patch mixed inorganic materials for pets, and their process - Google Patents

Abstract

The present invention relates to a pet hydrogel patch containing an inorganic material that can be dissolved in external environmental conditions. The present invention provides an effective ingredient to a pet product, and at the same time, an inorganic material that can be continuously delivered to a pet for a predetermined time is mixed. Hydrogel patch is a dog hydrogel patch, characterized in that to prevent the penetration of bacteria and foreign substances with the effect of alleviating skin wounds and troubles from the external physical force.
The present invention promotes wound healing of pet animals by using a gel that is soluble when adhered to the skin, reduces the pain caused by the wound by returning to the state before the wound, and prevents the occurrence of severe scars for a long time. Recover damaged areas under environmental influences. An object of the present invention includes an inorganic material that has the effect of inhibiting the occurrence of scars and secondary infections by making the skin regenerate as fast as possible during wound healing, an agent for treating the skin, and an agent that helps the skin in the gel and is effective for skin adhesion. The entrained hydrogel is completely dissolved to develop a hydrogel patch that penetrates into the skin of a pet animal.
The present invention is a hydrogel patch incorporating a dissolvable inorganic material when the skin is adhered in the form of a formulation that can be innovatively applied to wound healing and pet grooming, in detail, the skin that can be used for wound treatment, beauty, scar removal, band, etc. The present invention relates to a hydrogel patch containing an inorganic material that can be dissolved during adhesion.

Description

Hydrogel patch mixed with inorganic materials and its manufacturing method {Hydrogel Patch mixed Inorganic Materials for Pets, and Their Process}

The present invention relates to a pet hydrogel patch composition and a method for manufacturing the same mixed with an inorganic material dissolved according to the external influence, the hydrogel composition can be effectively applied to wound healing and beauty when adhered to the skin of dogs It relates to a hydrogel patch composition and a method for producing the same.

   The skin of a pet animal is one of the organs that protects the pet's body from external stimuli, prevents the loss of water, and performs important life protection functions such as controlling the body temperature and preventing bacterial invasion. It causes the loss of its original function, and it causes various side effects and bacterial infection from the outside due to water loss, making it difficult to treat the affected area, or additional side effects such as secondary dysfunction or damage are severe. It also affects life extension. Therefore, in order to quickly heal wounds and to minimize secondary side effects, it is necessary to use wound dressings. When the skin of an animal is exposed to fine humid weather, the protection of the skin itself becomes weak. This causes a lot of skin secretions, such as sebum, the skin is stretched and the skin irritation caused by ultraviolet rays. So dogs need proper skin care. First, if you have sebum or other skin secretions, you should wipe them off immediately and wash them as often as possible to keep them clean and refreshed. However, if dogs are washed frequently, the skin loses moisture, which makes the skin dry and rough, so skin care is required to satisfy the absorption and supply of skin secretions. In addition, if the hair (hair) covering the skin of the animal is unsanitary care can also cause problems in the hygiene of people raising pets. Therefore, it is necessary to develop a product that can hygienically manage the hair of a pet and can absorb and remove skin secretions due to its absorbency.

The use of hydrogels mixed with inorganic materials to sanitize pet hair hygienically and to manage wound healing and skin problems can result in the rapid delivery of large amounts of inorganic materials and cosmetics from the hydrogels to the skin. Should be In order to satisfy such characteristics, the healing agent and the cosmetic agent in the hydrogel should be quickly and evenly delivered to the skin as compared with the conventional one. U. S. Patent No. 6,051, 425 describes the preparation of porous collagen dressing sheet materials made by lyophilization. Since the above techniques are required to use animal collagen, it is very expensive due to the high cost in the manufacturing process, and there is a problem of low hardness because it uses hydrated collagen gel. In addition, the freeze-drying method has the disadvantage of high energy consumption and long time.

Among the hydrogels used for wound treatment, the hydrogel types shown in US Pat. Nos. 5,501,661 and 5,489,262 form a form in which a hydrogel is applied to a polymer film layer having no permeability, and the polymer film layer is dehydrated or dried. The hydrogel layer absorbs the exudates in contact with the wound and maintains a moist environment to promote wound healing. However, due to low moisture permeability, it is impossible to use a wound with many exudates, and if the water swelling state continues, the dressing material collapses and causes troubles on the normal skin. The hydrophilic polyurethane foam dressing agent shown in U.S. Patent Nos. 5,445,604 and 5,065,752 is a structure in which the structure is lined with a film on both sides of the polyurethane foam, and the outer film is not mechanically perforated in the film contacting the wound surface. Since the moisture permeability is not sufficient, there is a problem that it is not suitable for long-term adhesion, there is a problem such that the regeneration tissue is attached due to the holes present in the film on the wound surface.

In general, dressing is used to effectively treat wounds of the skin such as wounds and traumas. Wound dressings require the ability to maintain adequate moisture at the contact surface with wounds, the ability to control wound secretions, ease of attachment and removal of dressings to wounds, and air and vapor permeability between external wounds. Insulation of the wound to the outside, resistance to the invasion of bacteria, non-toxic to the skin, excellent mechanical properties are required. The development of such dressing agents has been developed into the mainstream of dry dressing, but the revolutionary theoretical development of wet dressing instead of dry dressing has been developed by some important research results. Hinman and Maibach established a theory of the effect of moisture on wound healing, and by 1970 Michael et al. (Michael ZC, Hu and Mark Reeves, Biosorption of Uranium by Pseud omonas Aeruginosa strain CUS Immobilized in a Novel Matrix Biotechnology Progress, 13 (1), 1997) It contained a moderate amount of water in the wound, active epithelial cell migration, and shortened wound healing period. In particular, Winter proved that epithelial remodeling was about 40% faster in the presence of adequate moisture than in the wound. As the first dressing agent to meet this theory of wet environment, the first generation of modern dressings was launched in 1971 by Opportunity, Smith Nephew, which consists of polyurethane film, vinyl ether and adhesive. It is a semi-permeable film dressing that prevents the ingress of moisture and allows the permeation of gas and water vapor from the wound surface to prevent the skin around the wound from falling down and to prevent bacterial infection on the wound surface and to maintain a wet environment. Based on this theory, Opsite was widely used as an excellent dressing agent that satisfies the theory of wet environment, but its problems such as its properties and tackiness were revealed. Other manufacturers have developed a variety of materials that have attempted to improve the materials used for films and to change the pressure-sensitive adhesives to acrylates. This development resulted in the so-called second-generation dressings in the 1970s. A product using Convatec's Hydro colloid, a hydrocolloid is a generic term for a series of products based on hydrophilic polymers and is widely used in wound, stoma and incontinence management devices. . The emergence of hydrocolloids has helped significantly in the treatment of wound healing, especially chronic refractory skin ulcers such as pressure sores and lower ulcers. These dressings are not just covering the wounds and absorbing the secretions, but are being studied in various ways, including proper moisture to help remodel epithelium and prevent bacterial invasion.

In the study of drug delivery system (DDS), Zeng and Aeng (J. Control, Release, 92, 227 (2003)) have applied drugs to biodegradable poly (L-lactic acid) (PLA). After the nanofibers were prepared by incorporation and electrospinning, the release properties of the drug were evaluated. The release of the drug was not influenced by the diffusion or permeation of the drug inside the nanofibers, but only by the decomposition of the polymer fiber as a carrier. As such, the release of drugs is determined by the presence of proteinase K, which degrades PLA, and research and industrialization efforts are being made in the medical industry.

In general, it is difficult to attach a protection device for a long time to the beauty of the pet and to treat skin wounds. In particular, most pets are hairy, so if a wound or skin trouble occurs, the dressing agent cannot be applied directly to the skin. To enhance this effect, water-soluble polymer hydrogel patches containing inorganic materials such as silver nano, gold nano and clay that swell during wet absorption can be developed to effectively manage wound healing and skin troubles of pets. Can be. In particular, it may be effective if it contains a drug that can manage the simulated hygiene. These pet hydrogel patches contain drugs that can enhance affinity between skin and hygienically manage hair, especially when inorganic materials and cosmetics or drugs are dissolved, drugs are delivered to the skin, and the characteristics of inorganic materials Determining the correct antibacterial and temperature control of the skin can be very effective for pet skin care. That is, in the hydrogel patch containing an inorganic material having a high affinity for skin, the delivery of a cosmetic or drug to the skin of a dog can occur easily and quickly.

In this regard, the hydrogel patch for pets mixed with the inorganic material of the present invention can be dissolved slowly, and the pet dog mixed with inorganic materials for the treatment of beauty and wounds for the purpose of dogs can be quickly and evenly delivered to the skin. To provide a hydrogel patch and a method for producing the same.

According to one aspect of the invention,

0.1-90% by weight of at least one synthetic polymeric material selected from the group consisting of polyvinyl alcohol (PVA), polyethylene glycol (PEG), polyethylene oxide (PEO), polyvinyl acrylic acid (PVAc), and polymethacrylic acid (PMAc); Collagen, gelatin, agar, carrageenan, alginate, chitosan, chitosan derivatives, starch pullulan, galactomannan, glucomannan, guar gum, locust bean gum, pluronic, algin, elastin, pulloteoglucan, PLA, PGA, PLGA Hydrogels composed of 0.1-90% by weight of at least one natural polymeric material selected from the group consisting of xanthan and gellan may be used.

히드록시산, 레티놀, 비타민 C, 비타민 C유도체, 비타민 A, 비타민 E, 아미노산, 구아바, 포도씨앗 추출물, 카모마일, 히알루로닉산, 어성초, 도인, 도인피, 파란근, 리기다, 상황, 영지버섯, 신이화, 포공영, 율피, 동백유, 피톤치드, 버드나무, 자작나무, 소나무추출물, 감자, 감초, 고삼, 갈조, 굴, 그레이프씨드, 꿀, 녹차, 당근, 당약, 들국화, 딸기 로즈마리, 마카데미아넛 오일, 마트리카리아, 비피두스, 사플로워오일, 상백피, 세이지, 수세미, 식물성 스쿠알렌, 세리신, 피브로인, 아카시아. 쌀, 쑥, 아몬드오일, 아보카도오일, 아이비, 알로에, 옥수수, 올리브오일, 우유단백질, 울금, 유용성감초, 인삼, 작약, 장미, 창포, 천궁, 치자, 코코넛오일, 파슬리, 헨나, 호스테일, 호호바오일, 황토 등으로부터 최소 하나 또는 둘 이상 사용가능하고, 항상화, 항균성, 항염증성, 항세포독성, 항자극성, 항알러지성, 보습성, 미백효과, 수렴효과, 진정효과 등을 부여할 수 있는데, 0.1중량% 내지 30중량% 사이의 함량을 갖는 것을 특징으로 한다. 이것은 0.1중량%이하의 경우 효능이 미비하여 30중량%이상의 경우 추출물의 고유적인 색소가 전체의 제품에 영향을 미칠 수 있는 단점을 가지고 있다. In order to effectively manage skin troubles, skin-friendly natural materials are used. Natural materials include ceramide, kojic acid, a-hydroxy acid and

Hydroxy acids, retinol, vitamin C, vitamin C derivatives, vitamin A, vitamin E, amino acids, guava, grapeseed extract, chamomile, hyaluronic acid, effervescent, cabbage, cabbage, blue root, rigida, situation, ganoderma lucidum, Shin Ehwa, Pogongyoung, Yulpi, Camellia Oil, Phytoncide, Willow, Birch, Pine Extract, Potato, Licorice, Red Ginseng, Brown Sea, Oyster, Grape Seed, Honey, Green Tea, Carrot, Sugar, Wild Chrysanthemum, Strawberry Rosemary, Macadamia Nut Oil , Matricaria, Bifidus, Saffron Oil, Morus, Sage, Scrubber, Vegetable Squalene, Sericin, Fibroin, Acacia. Rice, mugwort, almond oil, avocado oil, ivy, aloe, corn, olive oil, milk protein, turmeric, useful licorice, ginseng, peony, rose, iris, celery, gardenia, coconut oil, parsley, henna, hostile, jojoba It can be used at least one or two from oil, ocher, etc., it can give homeostasis, antimicrobial, anti-inflammatory, anti-cytotoxic, anti-irritant, anti-allergic, moisturizing, whitening, astringent, calming effect, etc. It is characterized by having a content between 0.1% to 30% by weight. This is less than 0.1% by weight of the efficacy is less than 30% by weight has a disadvantage that the intrinsic pigment of the extract can affect the whole product.

Inorganic materials capable of imparting functionality may be provided with hydrogel patches containing 0.01-30% by weight of at least one material selected from materials such as MMT, Nano Ag, Au, SiO ₂ , TiO ₂ , ZnO, CdS, and the like. have.

Hydrogel incorporating the soluble inorganic material of the present invention promotes the healing of dogs and wounds, as close as possible to the state before the wound to reduce the pain caused by the wound, as a preparation for preventing severe scars In the early stage of wound healing, hemostasis can be performed by compressing the wound area, and the active ingredient is slowly released to promote healing of the wound, to help rejuvenate the damaged skin, and to regenerate the skin as soon as possible during the wound healing process. It provides a formulation used for wound treatment and pet dog grooming to help prevent scars, and to provide a hydrogel containing inorganic materials that are completely dissolved when the skin adheres to the active ingredients penetrated into the skin.

Hydrogel incorporating the inorganic material of the present invention is in the form of a formulation that can be curatively treated for wound treatment and dog grooming, in detail can be effectively used for wound treatment, scar removal, bands and the like.

The hydrogel patch containing the inorganic material for pet dog beauty and wound treatment of the present invention is a hydrogel containing a skin treatment and a beauty agent that can be dissolved when attached to the skin to improve the skin trouble enhancer and mock hygiene management. It is characterized in that a large amount of active ingredients such as drugs can be quickly delivered into the skin.

The hydrogel mixed with the inorganic material of the present invention is manufactured as a patch for dog beauty, mock hygiene management and wound treatment, so that it gradually dissolves when attached to the skin, so that an active ingredient such as a dog beauty agent or wound treatment agent is well delivered to the skin. In addition, the hydrogel contains a natural affinity enhancer that enhances skin transfer of inorganic materials and active ingredients, so that a satisfactory amount of active ingredients can be rapidly delivered into the percutaneous skin. Therefore, the hydrogel in which the inorganic material is mixed in the present invention is dissolved by a small amount of moisture present in the skin and thus provides a novel hydrogel patch for grooming and wound treatment, characterized in that it changes to an aqueous solution state. It is.

Composite compositions such as synthetic polymers, natural polymers, and effective natural drugs can be prepared in high concentrations and prepared in the form of sheets and patches using the freezing-thawing method. In particular, it was found that the degree of receptivity of the sheets and patches can be controlled by adjusting the freezing temperature by adjusting the freezing temperature from minus 70 degrees to minus 1 degree or by adjusting the thawing temperature from 1 degree to 50 degrees when freezing and thawing were produced. It was possible to complete the present invention.

The hydrogel composition in which the inorganic material of the present invention is mixed is dissolved in the hydrogel state when the sheet or patch is applied to the skin, thereby improving the affinity between the composition and the skin, thereby providing a pet dog beauty agent. There is a characteristic to be well delivered to the skin, and also has an inorganic material that removes the bacteria of the skin in the composition is characterized in that it can quickly obtain a satisfactory effect. Therefore, the present invention provides a hydrogel composition incorporating a new inorganic material, characterized in that the hydrogel in which the inorganic material is incorporated changes rapidly in a fluid state.

Hydrogel incorporating the inorganic material of the present invention has a physical property that the solid state changes to a liquid state (liquid state) by the influence of the skin. In particular, when used in the application of pet dog grooming products in the form of a hydrogel sheet (sheet) or patch (patch) incorporating the inorganic material of the present invention to the skin to change the flow state to change to a flowable composition It is a feature that greatly enhances the affinity with the skin while being in close contact with the skin automatically.

The hydrogel incorporating the inorganic material of the present invention prepared as described above is gradually dissolved by moisture when the skin is in contact, so that the active ingredients penetrate the skin, thereby promoting the healing of the wound, and returning it as close as possible to the wound before the wound. It is a preparation to reduce the pain caused and to prevent severe scars, and it is possible to bleed the wound area by pressing hydrogel with inorganic material in the early stage after the wound, and the active ingredient is gradually released to promote wound healing. It helps to regenerate damaged skin, and to regenerate the skin as soon as possible during wound healing, and is used for wound treatment and dog grooming to help prevent scars. In addition, the hydrogel incorporating the inorganic material of the present invention can be used for dog grooming, mock hygiene management, scar removal, bands and the like.

Example 1-7 (Preparation of Hydrogel with Inorganic Materials)

Each component was mixed as shown in Table 1 while stirring in a 1 L container at room temperature. First, the synthetic polymer material was added to deionized water, the temperature was raised to 70, and then completely dissolved under slow stirring. Then, the natural polymer material and the skin-friendly natural product were added later at room temperature.

Then, the gel in the form of a patch was formed through freeze thaw at minus 30 degrees and image 10 degrees.

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 PVA
(Polyvinyl alcohol) 4 5 6 7 6 5 4 Collagen 20 20 30 30 40 40 50 Silver nanoparticles One One One One One One One

Example 8-Solubility Experiments

Hydrogel containing the inorganic material prepared in the same manner as in Example 1-7 was measured by varying the water content to 0, 1, 5, 10, 20, 50% by weight of the solubility. The results are shown in Table 2.

In the absence of moisture, the hydrogel containing the inorganic material was not dissolved at all, but was dissolved in water of 1-5% by weight. Therefore, it was found that the hydrogel mixed with the inorganic material of the present invention was sufficiently soluble even with a small amount of water of 1-5%.

moisture% Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 0 X X X X X X X One O O O O O O O 5 O O O O O O O 10 O O O O O O O 20 O O O O O O O 50 or more O O O O O O O

;일부 용해됨, O;완전 용해됨)(X; not soluble,

; Some dissolved, O; fully dissolved)

Example 9-Cell Activity Test

Cellular activity test of macrophage Raw 264.7 cells was performed on the hydrogel containing the inorganic material prepared in Example 1 above. After dispensing cells into the T-bottle, the cells were replaced with serum free EMEM when reaching 80% confluency. Hydrogel containing the prepared inorganic material was added to a 6 well plate, and macrophage Raw 264.7 cells were divided into cells of 5 × 10 ⁴ cells / well, and then cell activities were measured for 24 hours and 48 hours. As a result of the measurement as described above, the cell culture was increased by 2-4 times after 48 hours and the cell activity was excellent.

Example 10 Antibacterial Test

The hydrogel incorporating the inorganic material of the present invention prepared in Example 1 was commissioned to the Textile Testing Laboratory (FITI), and the antimicrobial test was performed by the antimicrobial test method ((FC-TM-20) -2001). The results are shown in the table below (the hydrogel in which the inorganic material soluble in the skin adhesion of the present invention is mixed is prepared by preparing a soluble hydrogel in the skin adhesion of Example 1 and conditioning sufficiently).

 After inoculating the inoculated microorganisms on the antimicrobial processed product and the control piece, the number of viable cells was measured, and the activity of inhibiting the growth of the bacteria by comparing the antimicrobial processed product (processed fabric) and the control piece (standard fabric) (microbial reduction rate) Is calculated by the following equation.

Reduction of bacteriostatic percentage = (C-B) / CX100

(B = number of bacteria after culture of processed cloth, C = number of bacteria after orientation of standard cloth)

moisture% Average number of bacteria Test establishment 0 1) Test bacteria 2) coliform bacteria 1) public bacteria 2) public bacteria Initial bacterial count ("0" hours) 2.0 X 10 ⁴ 1.9 X 10 ⁴ 105 times increase
(More than 31.6 times) 200x increase
(More than 31.6 times) After standard culture 2.1 X 10 ⁶ 3.8X10 ⁶ Type of test Reduction of bacteriostatic rate (%) 1) Test bacteria 2) public bacteria Indication 99.9 or more 99.9 or more Nonionic surfactant Use 0.05% nonionic surfactant (TWEEN 80) for inoculation bacteria STOMACHER 400POLY-BAG

Test bacteria: 1) Staphylococcus aureus ATCC 6538

2) Klebsiella pneumoniae ) ATCC 4352

As shown in the above table, the hydrogel containing the soluble inorganic material of the present invention has a bacteriostatic rate of 99.9% or more for Staphylococcus aureus and Klebsiella pneumoniae . It can be seen that it has a very good antibacterial properties.

Claims (4)

0.1-90% by weight of synthetic polymers, 0.1-90% by weight of natural polymers, 0.1-30% by weight of skin-friendly natural active ingredients, inorganic materials0.01- 1, based on the total weight of the composition 30% by weight, prepared by freezing and thawing sheet and patch form prepared by adjusting the freezing temperature from minus 70 degrees to minus 1 degree, or thawing temperature is repeated once or 20 times from image 1 to 50 degrees Sheets and patches and methods of manufacturing them
The polymer according to claim 1, wherein the polymer capable of forming the hydrogel in which the inorganic material is incorporated is polyvinyl alcohol (PVA), polyethylene glycol (PEG), polyethylene oxide (PEO), polyvinyl acrylic acid (PVAc), and polymetha. 0.1-90% by weight of at least one synthetic polymeric material selected from the group consisting of acrylic acid (PMAc) and collagen, gelatin, agar, carrageenan, alginate, chitosan, chitosan derivatives, starch pullulan, galactomannan, glucomannan, guar gum, Hydrogel sheets and patches composed of 0.1-90% by weight of at least one natural polymeric material selected from the group consisting of locust bean gum, pluronic, algin, elastin, pulloteoglucan, PLA, PGA, PLGA, xanthan and gellan
The method of claim 1, wherein the skin-friendly natural active ingredient used is ceramide, kojic acid, a-hydroxy acid and

Hydroxy acids, retinol, vitamin C, vitamin C derivatives, vitamin A, vitamin E, amino acids, guava, grapeseed extract, chamomile, hyaluronic acid, effervescent, cabbage, cabbage, blue root, rigida, situation, ganoderma lucidum, Shin Ehwa, Pogongyoung, Yulpi, Camellia Oil, Phytoncide, Willow, Birch, Pine Extract, Potato, Licorice, Red Ginseng, Brown Sea, Oyster, Grape Seed, Honey, Green Tea, Carrot, Sugar, Wild Chrysanthemum, Strawberry Rosemary, Macadamia Nut Oil , Matricaria, Bifidus, Saffron Oil, Morus, Sage, Scrubber, Vegetable Squalene, Sericin, Fibroin, Acacia. Rice, mugwort, almond oil, avocado oil, ivy, aloe, corn, olive oil, milk protein, turmeric, useful licorice, ginseng, peony, rose, iris, celery, gardenia, coconut oil, parsley, henna, hostile, jojoba Hydrogel sheets and patches composed of at least one or two or more from oil, loess, etc. According to claim 1, Hydrogel sheet and patch consisting of at least one or more selected from among materials such as MMT, Nano Ag, Au, SiO ₂ , TiO ₂ , ZnO, CdS of the inorganic material