WO2006026928A1

WO2006026928A1 - The vulneraria and the method for producing and using it

Info

Publication number: WO2006026928A1
Application number: PCT/CN2005/001441
Authority: WO
Inventors: Yiming Lv
Original assignee: Yiming Lv
Priority date: 2004-09-09
Filing date: 2005-09-09
Publication date: 2006-03-16
Also published as: CN1628675A; CN1279917C

Abstract

The present invention discloses a vulneraria containing sucrose and/or glucose as effective ingredient and the suitable adjuvant in any dose form for haemostasis, dephlogisticate and promoting the healing of wound, without or reducing antibiotic, and the method for producing and using it.The vulneraria spend lower cost, and is produced simply and convenience to use.

Description

Wound medicine and preparation method and use method thereof

The invention relates to a wound medicine, a preparation method thereof and a use method. Background technique

In order to effectively treat the wounds on the skin of human body and other animals, people often apply antibacterial and anti-inflammatory drugs to the wounds, but the antibacterial and anti-inflammatory drugs are only antibacterial and have no effect of enhancing wound healing. The wound healing period is long and scars are easy to form. It takes time and effort to use it, especially when it is in an emergency such as a disaster. Summary of the invention

The problem to be solved by the present invention is to provide a wound medicine having a function of hemostasis, anti-inflammatory and wound healing, a preparation method thereof and a use method.

In order to solve the above problems, the present invention adopts the following technical solutions:

The wound medicine of the present invention is a wound medicine of any dosage form which is prepared by dispensing sucrose and/or glucose as an auxiliary ingredient.

In one embodiment, the concentration of sucrose and/or glucose is any concentration.

In another embodiment, the sucrose and/or glucose are in the form of fibers.

The dosage form of the present invention is a composite dressing, a wound wound medicine, a lotion, a rinsing agent, a spray, an ointment, a powder, a paint, and the like. The medical composite dressing includes the medical cotton pad, the medical gauze, the medical gauze tape, the medical perforated film, the medical breathable adhesive film, the medical through-hole foam, the wound patch, the first aid belt and the like.

The present invention also provides a method of preparing a wound medicine comprising the steps of: heating sucrose and/or glucose, melting it, and then forming a soft fiber by techniques well known in the art. These technologies include blowing with compressed air and using a centrifugal cotton machine. The fibers are layered over the dressing and isolated with a medical PE film or waxed tissue.

The invention provides a method for using a wound medicine, which is suitable for all human skin Wounds, including skin cracks caused by stab wounds, sharp scratches, abrasions, impacts, bruises, bruises, wounds, bloodless people, need to squeeze out blood or add clean water to dissolve sucrose and / or glucose in the wound, The dry wound is moistened and the wound medicine is then applied directly to the wound.

The invention also provides a method for using a wound medicine. After the wound of the old rotted wound is washed with hydrogen peroxide, the unconformed wound is washed with the disinfectant, and then washed with the powder-type wound medicine, and the wound medicine is directly applied to the wound.

Sucrose and glucose have hemostasis, anti-inflammatory and heal-promoting effects on human wounds. The effect of sucrose and glucose is that they are not allergic to human body and have good affinity for human tissues. After the high concentration of sucrose and glucose are in contact with blood, due to the principle of osmotic pressure, it can promote platelet aggregation and achieve rapid hemostasis, and form a membrane-like protective layer to prevent invasion of external bacteria, and high osmotic pressure simultaneously invades. The water in the bacterial cell wall is infiltrated to achieve bacteriostatic action. After sucrose and glucose molecules are immersed in human tissues, they can oxidize tissues through oxidation, provide energy for cell division, increase the phagocytic ability of white blood cells, promote the growth of wound granulation tissue, and thus promote the elimination of wound inflammation and make the wound heal faster. The remarkable healing effect of sucrose and glucose can reduce the formation of collagen fibers, thereby reducing the production of scar tissue. No or no antibiotics are needed.

The invention can be made into any dosage form suitable for treating wounds, including medical composite dressings, roll-shaped drug originals, lotions, rinsing agents, sprays, ointments, powders, paints, etc., low cost, single process, easy to use .

The sucrose and glucose are made into saccharose fiber cotton and compounded on the dressing material, and can be made into wound patch and composite dressing of various sizes, or the saccharide fiber can be composited by a separator film and a gas permeable film to form a roll product. For free cutting and application, sucrose, glucose alone or with other drugs can be used as a solution, mixed solution or powder tank, for all new and old wounds to be cleaned and washed again, in order to promote the healing of irregular wounds. Mix sucrose or glucose with glycerin, etc., and make a paste into the hose for use in wartime or in the wild. You can also use sponge fabric, through-hole, open-cell sponge to adsorb sucrose and glucose through glycerol. Rolled cotton wool with a certain width and covered with a separator film can be freely cut according to the size of the wound, and then the tearing off the barrier film to cover the wound, and then wrapped. It is easy to use, easy to apply, dissolve, absorb fast, and ensure the cleanliness of the wound. It can also be mixed with other drugs to make a powder for easy carrying.

The actual use of skin cracks caused by bruises, bruises, and impacts on human skin of different ages and genders, as long as sucrose is fully dissolved in the blood, there is no need to wipe off the blood. Blood, the purpose is to try to discharge infected bacteria and dirt, and help dissolve sucrose. Blood-free wounds should be added with boiled water to dissolve sucrose, then wrapped with gauze, must be kept aerated, if the wound is dry, it should be moistened. Generally, after 3 to 8 hours, the wound has no effect even if it enters domestic water, and it can be used normally. The old wound that has not been used for the wound medicine has been scarred, the skin of the skin is closed, and there is pus in the water, and the redness is swollen. The wound is opened, and the wound-type wound medicine is washed, and then the wound dressing compound dressing is applied. Wounds that injure the dermis will heal in 2 to 3 days, and those who have subcutaneous muscle tissue will eventually heal or heal in 3 to 5 days. After application with sucrose or glucose, the wound has almost no redness, swelling and pain, and the wound has no exudate and is clean. If the same wound is scrubbed with red mercury and sulfamethoxazole is applied, the wound is red and swollen for a period of time, and exudate is produced. At the same time, the wound is not clean and clean, the healing time is longer, and scarring occurs. It is well known that the blood circulation of the human humerus skin is poor, and the skin wound is not easy to heal. With the wound medicine applied by the present invention, even if the skin is swollen and bruised, the wound bleeding can be improved in about three days. Healed in 4 - 5 days.

The invention has been clinically observed in 300 patient systems.

Diagnostic criteria: Knife, bruise, sharp scratches, hammer damage, hard bumps, bleeding.

Treatment: Application using the present invention.

Effective standard:

1. Cure: The wound converges and heals;

1, effective: hemostasis, wound improvement 3. Invalid: The above conditions have not improved.

Clinical observation for 24 hours was a course of treatment, and 1 to 3 courses were observed. Among them, 2 cases were cured in the first course, 280 cases were effective, and 18 cases were ineffective. In the second course, 201 cases were cured, 87 cases were effective, and 12 cases were ineffective. In the third course of treatment, 243 cases were cured, 53 cases were effective, and 4 cases were ineffective.

100 cases were treated with transverse amine crystal dressing as a control group, and the results are shown in Table 1. Table 1 300 clinical observation results

detailed description

The heater used in the following examples is an oil bath thermostat heater. All finished products should be sterilized by ethylene oxide after packaging. The package has good water resistance, good air tightness and no pressure. All sucrose and/or glucose powders are ground and sieved through a 60 mesh screen.

Example 1 Preparation of sugar fiber cotton

Use edible white sugar or edible glucose powder in accordance with national standards to melt in oil bath thermostat heater, pay attention to control temperature lower than its decomposition temperature, and then be preheated with constant temperature The stainless steel tube is introduced into the blower, and the air passing through the air purifier is introduced into the blower through a high-pressure air pump to spray the molten sugar liquid into a soft sugar fiber cotton.

Example 2 Preparation of composite dressing

After the saccharide fiber cotton prepared in Example 1 is formed into a fiber wool layer of a certain thickness on a conveyor belt, it is rolled into a cotton wool layer of a predetermined specification by a roller, and then the sugar cotton layer is composited on the dressing substrate, and the dressing substrate includes Gauze, gauze, cotton, the material can be cotton, medical non-woven, medical PE breathable film and breathable fabric or non-woven fabric with self-adhesive. Composite method of sugar cotton: It can be easily adsorbed on fiber fabric or non-woven fabric. For relatively smooth film or fabric which is difficult to adsorb, it can be printed with point-shaped medical adhesive or medical adhesive. Then adhere. For the composite dressing in the form of a roll, in order to prevent the adhesion of the cotton wool to the other side of the fiber fabric, a separator may be covered, and the separator may be a plastic film or a smooth tissue paper which is waxed.

Example 3 Preparation of lotion, rinsing agent, spray

The ground sucrose or glucose powder is heated to 75 ° C in a water bath thermostat for 3 minutes, treated with acaricidal treatment, treated sucrose and / or glucose added to the distilled water, at room temperature of 15 - 37 ° C Stir the sucrose or glucose to a saturated solution, and allow the solution and the rinsing agent to have 10 to 50% of crystalline insoluble matter.

Example 4 Preparation of Sponge Dressing

' Sponge fabric or through-hole foam is wetted with 0.5-100% glycerol solution, then passed under vacuum suction, and the milled sucrose or glucose powder on the turntable is heated in a water bath thermostat heater to The temperature was maintained at 75 °C for 3 minutes, and the acaricidal treatment was carried out. The treated sucrose and/or glucose were inhaled and adsorbed on the dressing by the adsorption of glycerin.

Example 5 Preparation of Ointment

Add sucrose or glucose to 0.5 to 15% of medical glycerin, add an appropriate amount of distilled water, grind into a paste in a stainless steel grinder, and infuse it into a hose to seal.

Example 6 Preparation of powder

Take 70 - 80% of the sucrose powder that has been ground through a 60 mesh sieve and add 15 - 30 The medical zinc oxide powder which was dried and sterilized at 150 ° C for 2 hours and passed through a 60 mesh sieve was uniformly mixed and packaged in a sealed container.

Example 7 Usage of Trauma Drugs

The invention is applicable to the wounds of all skins of human bodies and other animals, including skin cracks caused by stab wounds, sharp scratches, abrasions, bruises and bruises caused by impacts, and bloody wounds need to be squeezed out of blood or wounds. Adding clean water to dissolve sucrose and/or glucose, infiltrating into the inside of the wound, and wetting the dry wound. If the old wound is closed, the exudate or pus and the skin are red and crusted, the wound should be closed. Open, and then the wound medicine is applied directly to the wound. The amount of the wound medicine is about 10 - 30 liters around the wound surface. Example 8 Usage of Trauma Drugs

After the old rot wound wound is rinsed with hydrogen peroxide, the untidy wound is washed with the disinfectant, and then washed with the wound medicine lotion, and the wound medicine is directly applied to the wound. About 10 - 30 周边 around the wound surface

While the various aspects and features of the present invention are described herein with reference to the preferred embodiments, the embodiments of the present invention are intended to be illustrative and not limiting. The scope of the invention is limited only by the claims. It is obvious to those skilled in the art that the present invention may be appropriately modified or changed without departing from the spirit and scope of the claims, and such modifications or changes are also intended to fall within the scope of the present invention.

Claims

Rights request

1. Use of sucrose and/or glucose for the preparation of a wound medicine.

2. A wound medicine characterized in that it is based on sucrose and/or glucose.

3. The wound medicine of claim 2, characterized in that it further comprises a suitable excipient.

The wound medicine according to claim 2, characterized in that the concentration of sucrose and/or glucose is any concentration.

5. A wound medicine according to claim 2, characterized in that the sucrose and/or glucose are in the form of fibers.

The wound medicine according to claim 2, characterized in that the wound medicine can be formulated into the following dosage forms: a medical composite dressing, a wound wound medicine, a lotion, a rinse, a spray, a soft paste, a powder or a paint.

7. The wound medicine according to claim 6, wherein the medical composite dressing comprises a medical cotton pad, a medical composite gauze, a medical composite gauze tape, a medical composite perforated film, a medical composite breathable adhesive film, and a medical composite through hole. Foam, medical composite sponge, bandage, first aid belt.

A method of preparing a wound medicine according to any one of claims 2 to 7, characterized in that it comprises the steps of: heating sucrose and/or glucose, melting it, and then forming a soft fiber, The fibers were layered over the dressing and isolated with a medical PE film.

A method of using the wound medicine according to any one of claims 2 to 7, characterized in that the wound medicine is used to treat wounds of human and other animal skin, including stab wounds, sharp scratches, abrasions, impacts. Skin ruptures caused by skin ruptures, gunshot wounds, bruises and stale rot wounds.