CN1628675A

CN1628675A - Vulnerary, its preparation method and process of using

Info

Publication number: CN1628675A
Application number: CNA2004100746263A
Authority: CN
Inventors: 吕益明
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-09-09
Filing date: 2004-09-09
Publication date: 2005-06-22
Anticipated expiration: 2024-09-09
Also published as: WO2006026928A1; CN1279917C

Abstract

The invention discloses a vulnerary, its preparation process and method of use, wherein the medicament is prepared by using sucrose and/or glucose as effective compositions and right adjuvant. The medicament has the functions of haemostasis, anti-inflammation and facilitating wound healing and the advantages of low cost, simple process for manufacturing, and ease in use.

Description

A kind of vulnerary and preparation method thereof and using method

[technical field]

The present invention relates to a kind of vulnerary and preparation method thereof and using method.

[background technology]

For the wound on human body and other animal skins can be obtained the effective treatment, people usually coat antibiosis anti-inflammatory drug at wound, there is not the composition that strengthens the wound healing function but antibacterial-anti-inflammatory drug is only simple antibiotic, the wound healing cycle is long, form cicatrix easily, using wastes time and energy, and when particularly meeting with emergencies such as the condition of a disaster, can't in time handle.

[summary of the invention]

The problem that the present invention need solve just is to provide a kind of wound is had hemostasis, antiinflammatory and promotion wound comparatively fast the heal vulnerary and preparation method thereof and the using method of function.

For addressing the above problem, the present invention adopts following technical scheme:

Vulnerary of the present invention, it is to be the vulnerary that effective ingredient is equipped with any dosage form that suitable treatment wound that adjuvant makes uses with sucrose and/or glucose.The concentration of sucrose and/or glucose is for arbitrarily.

Dosage form of the present invention is combine dressing, web-like vulnerary, lotion, irrigation, spray, ointment, powder, varnish etc.Wherein said medical combine dressing comprises medical cotton pad, hospital gauze, medical cotton yarn tape, medical hole film, medical air-permeable adhesive membrane, medical through-hole foam plastics, bandage, first aid band etc.

The present invention also provides a kind of preparation method of vulnerary, and it comprises following step: heating sucrose and/or glucose make its fusing, jet with compressed air then, become a kind of softish fiber, become stratiform multiple in dressing described fiber lay down, and isolate with the medical PE film or the thin paper of waxing.

The invention provides a kind of usage of vulnerary, it is applicable to the wound of all human body skins, the skin breach that causes is hindered in the congestion swelling that comprises knife injury, sharp object to scratch, abrade, clash into and cause, wound depletion of blood person need extrude blood or add clean water and make sucrose and/or glucose dissolving in wound, need carry out moistening to drier wounds, then described vulnerary be directly acted on wound.

The present invention also provides a kind of usage of vulnerary, and outmoded rotten wound surface is after the hydrogen peroxide flushing, and irregular wound cleans with this lotion type vulnerary after disinfectant cleans, and more described vulnerary is directly acted on wound.

Sucrose, glucose are to hemostasis, antiinflammatory and the promoting healing effect of human body wound; the generation of its effect is because sucrose, glucose has that human body is not had anaphylaxis; to the affinity of tissue characteristics preferably; the sucrose of high concentration, glucose and after blood contacts; because osmotic pressure principle; can intensify platelet and leukocyte, erythrocytic coagulation function; reach the purpose of quick-acting haemostatic powder; and form a kind of membranaceous protective layer; prevent the intrusion of extraneous antibacterial, hyperosmosis makes the interior moisture content of the bacteria cell wall of having invaded be reached bacteriostasis by imbibition simultaneously.After sucrose, glucose molecule immersed tissue, energy nutritive issue increased fissional energy, and the phagocytic activity of leukocyte increasing, increases the growth of wound granulation tissue, thereby impels the very fast elimination of wound inflammation, and wound is comparatively fast healed.Sucrose, the significant promoting healing effect of glucose still can reduce the formation of collagen fiber, thereby reduce the generation of scar tissue.

The present invention can make the dosage form of any suitable treatment wound, comprises medical combine dressing, the former medicine of web-like wound medicine, lotion, irrigation, spray, ointment, powder, varnish etc., and with low cost, technology is simple, and is easy to use.

Sucrose, glucose are made sugared cellucotton, be compounded in above the dressing, can make bandage, combine dressing that all size does not wait, perhaps above-mentioned sugared fiber is made rolled article with isolated film and breathable films after compound, can apply ointment or plaster for free cutting at any time, with sucrose, glucose separately or and other medicine to make solution, mixed solution or powder canned standby, clean once more after cleaning for all new and old wounds, in order to the promoting healing of irregular wound.With mixing such as sucrose or glucose and glycerol, make paste and pour into flexible pipe, in order to portably using in wartime or field, also can be with spongy fabric, through hole, porous sponge, by glycerol absorption sucrose, glucose, make certain width, have the web-like sugar of isolated film cotton again up and down, can be during use according to the free cutting of wound size needs, tear isolated film then off and be covered in wound, then wrapping.With sugar cotton than Powdered easy to use, execute and apply evenly, dissolving, absorb fast, as to guarantee wound sanitation and hygiene.Can also make powder with other medicament mixed, have easy to carry.

The knife injury of the human body skin of all ages and classes, different sexes, scratch, bump are caused congestion swelling hinders the actual use treatment of the skin breach that causes, as long as sucrose fully dissolves in the blood, need not wipe blood, the depletion of blood person need extrude blood, and purpose is to discharge infected antibacterial and dirt as far as possible, and helps dissolving saccharose, the depletion of blood wound should add boiled water with dissolving saccharose, with gauze wrapping, must keep ventilation then, if drying should be in addition moistening for wound.Even general after 3-8 hour wound enter domestic water and also do not have influence, can normal activity.Do not form a scab with the old wound of this vulnerary, the epidermis skin is remained silent, and in pus is arranged, red and swollen person makes wound open, with the cleaning of this lotion type vulnerary, applies this vulnerary combine dressing then.Promptly restrained healing in wound 2-3 days that injure corium, and injured subcutaneous muscular tissue person, promptly basic healing in 3-5 days or healing.With sucrose, glucose execute apply after, red, swollen, pain phenomenon that wound almost seldom has, and wound do not have transudate, cleaning totally.If same wound with mercurochrome clean, sulfanilamide crystal applies and executes wrapping, wound many red and swollen periods, and have transudate to produce, wound clean cleaning in the identical time, healing time is longer, and can produce cicatrix.As everyone knows, human tibia portion cutaneous circulation is relatively poor, and skin wound is difficult for healing, executes with wound drug application of the present invention, even this place is made the swelling of skin generation congestion by bump, wound bleeding also can take a turn for the better about three days, promptly heals in 4-5 days.

The present invention is through the clinical observation of 300 routine patient systems.

Diagnostic criteria: knife injury, scratch, sharp object scratch, hammer wounds, hard thing is damaged, with hemorrhage.

Therapeutic Method: use the present invention to execute deposited.

Criterion of therapeutical effect:

1, cures: wound convergence healing;

2, effective: hemostasis, wound improve

3, invalid: above-mentioned condition of illness does not improve.

Clinical observation 24 hours was a course of treatment, observed 1-3 the course of treatment, wherein cured 2 examples, effective 280 examples, invalid 18 examples in the 1st course of treatment; Cure 201 examples, effective 87 examples, invalid 12 examples in the 2nd course of treatment; Cure 243 examples, effective 53 examples, invalid 4 examples in the 3rd course of treatment.

Apply with sulfanilamide crystal that to execute wrapping 100 examples be matched group, it the results are shown in Table 1.

Table 1 300 routine clinical observation result

	Cure						Effectively						Invalid
	Cure						Effectively						Invalid						Example	Ratio %	Wherein				Example	Ratio %	Wherein				Example	Ratio %	Wherein
	The man		The woman		The man		The woman		The man		The woman										Wherein						Wherein						Wherein
	The man		The woman		The man		The woman		The man		The woman		Example	％	Example	％	Example	?％			Example	％	Example	??％			Example	??％
	First course of treatment	2	?0.7	?1	0.3	?1	0.4	?280	?93.3	140	?47	?140	Example	％	Example	％	Example	?％			Example	％	Example	??％			Example	??％	46	18			????6	??9	??3	??9	??3
Second course of treatment	First course of treatment	2	?0.7	?1	0.3	?1	0.4	?280	?93.3	140	?47	?140	201	?67	?108	36	?92	31	?87	?29	40	?13	?47	16	12	????4	??6	??2	46	18	??6	??2	????6	??9	??3	??9	??3
Second course of treatment	The 3rd course of treatment	243	?81	?120	40	?123	41	?53	?17.7	25	?8.3	?28	201	?67	?108	36	?92	31	?87	?29	40	?13	?47	16	12	????4	??6	??2	9.4	4	??6	??2	????1.3	??2	??0.6	??2	??0.7
Matched group	The 3rd course of treatment	243	?81	?120	40	?123	41	?53	?17.7	25	?8.3	?28	68	?68	?37	37	?31	31	?26	?26	14	?14	?12	12	6	????6	??2	??2	9.4	4	??4	??2	????1.3	??2	??0.6	??2	??0.7

[specific embodiment]

The heating appliances that uses among the following embodiment is the oil bath thermostatic heater, and ownership finished product is answered ethane via epoxyethane sterilization after packing, and packing has excellent waterproofness, and air-tightness is good and can not pressure-bearing.All sucrose and/or glucose powder are and cross 60 mesh sieves behind grindings.

The preparation of embodiment 1 sugared cellucotton

Select for use the edible white sugar or the table grapes Icing Sugar that meet national standard in the oil bath thermostatic heater, to fuse, notice that the control temperature is lower more than 5-25 ℃ than its decomposition temperature, contained the homothermic stainless steel tube of preheating then and introduced Apparatus for spraying and jetting particulate materials, import Apparatus for spraying and jetting particulate materials through the air behind the air purifier through high-pressure pump, the liquid glucose of molten is jetted into softish sugared cellucotton.

The preparation of embodiment 2 combine dressings

With the sugared cellucotton of preparation among the embodiment 1 after becoming certain thickness cellucotton layer on the conveyer belt, be rolled into the cotton layer of sugar of regulatory specifications through roller, then the cotton layer of this sugar is compounded on the dressing matrix, the dressing matrix comprises gauze, cotton yarn tape, cotton, and material can be the breathable fabric or the non-woven fabrics of cotton, medical adhesive-bonded fabric, medical PE breathable films and band adhesive sticker.The complex method that sugar is cotton: on fabric or non-woven fabrics, can be adsorbed easily, on the fabric for the thin film of smoother or difficult absorption, can stamp the point-like medical pressure-sensitive adhesive or coat medical pressure-sensitive adhesive sticking then multiple.To being the combine dressing of web-like, for preventing the adhesion of sugar cotton and fabric another side, can cover one deck isolating membrane, isolating membrane can be used plastic sheeting, also can use the smooth thin paper of wax.

The preparation of embodiment 3 lotions, irrigation, spray

To in the constant temperature water bath heater, be heated to 75 ℃ of constant temperature 3 minutes through the sucrose or the glucose powder of grinding, do acarid processing extremely, treated sucrose and/or glucose add distilled water, under 15-37 ℃ of room temperature, sucrose or glucose are dissolved in stirring, the solution that reaches capacity allows solution and irrigation that the crystallization insoluble matter of 10-50% is arranged.

The preparation of embodiment 4 spongy dressing

Spongy fabric or through-hole foam plastics are moistening with the 0.5-10% glycerine water solution, under vacuum machine suction inlet, pass through then, to in the constant temperature water bath heater, be heated to 75 ℃ of constant temperature 3 minutes at sucrose or the glucose powder on the rotating disk through grinding, do acarid processing extremely, treated sucrose and/or glucose are inhaled into, and rely on the adsorptivity of glycerol to be adsorbed in the dressing.

The preparation of embodiment 5 ointment

Medical glycerol with sucrose or glucose adding 0.5-15% adds an amount of distilled water again, grinds to form paste in the stainless-steel grinding machine, is fed in the flexible pipe to seal.

The preparation of embodiment 6 powders

That gets 70-80% crosses the cane sugar powder of 60 mesh sieves through grinding, add content and be 15-30% through 150 ℃ of 2 hours dry sterilizations and cross the medical Zinc oxide powder of 60 mesh sieves, mix homogeneously is packaged in the sealed container.

The usage of embodiment 7 vulnerarys

The present invention is applicable to all human bodies and other zoodermic wounds, the skin breach that the congestion swelling wound that comprises knife injury, sharp object to scratch, abrade, clash into and cause etc. causes, wound depletion of blood person need extrude blood or add clean water on wound and make sucrose and/or glucose dissolving, infiltration wound inside, need carry out moistening to drier wounds, do not heal as old wound epidermis closure, or in transudate or pus and skin rubefaction incrustation are arranged, should closure of wound is open, then described vulnerary is directly acted on wound.The consumption of vulnerary is for covering the about 10-30MM of wound face periphery.

The usage of embodiment 8 vulnerarys

Outmoded rotten wound surface is after the hydrogen peroxide flushing, and irregular wound cleans with this vulnerary lotion after disinfectant cleans, and more described vulnerary is directly acted on wound.The about 10-30MM of wound face periphery.

Claims

1, a kind of vulnerary is characterized in that it is is the vulnerary that effective ingredient is equipped with any dosage form that suitable treatment wound that suitable adjuvant makes uses with sucrose and/or glucose.

2, the described vulnerary of claim 1, the concentration that it is characterized in that sucrose and/or glucose is for arbitrarily.

3, the described vulnerary of claim 1 is characterized in that wherein said dosage form is medical combine dressing, web-like vulnerary, lotion, irrigation, spray, ointment, powder or varnish.

4, the described vulnerary of claim 2 is characterized in that wherein said combine dressing comprises medical cotton pad, medical composite gauze, medical compound cotton yarn tape, medical compound hole film, medical compound ventilative adhesive membrane, medical composite via foam plastics, medical composite sponge, bandage, first aid band.

5, the preparation method of arbitrary described vulnerary of claim 1-4, it is characterized in that it comprises following step: heating sucrose and/or glucose, make its fusing, jet with compressed air then, become a kind of softish fiber, become stratiform multiple in dressing described fiber lay down, and isolate with medical PE film.

6, the usage of arbitrary described vulnerary of claim 1-4, it is characterized in that it is applicable to all human bodies and other zoodermic wounds, the skin breach that causes is hindered in the congestion swelling that comprises knife injury, sharp object to scratch, abrade, clash into and cause, wound depletion of blood person need extrude blood or add clean water on wound and make sucrose and/or glucose dissolving, need carry out moistening to drier wounds, do not heal as wound epidermis closure, or in transudate or pus and skin rubefaction incrustation are arranged, should closure of wound is open, then described vulnerary is directly acted on wound.

7, the usage of arbitrary described vulnerary of claim 1-4, it is characterized in that: outmoded rotten wound surface is after the hydrogen peroxide flushing, irregular wound cleans with this lotion type vulnerary after disinfectant cleans, and more described vulnerary is directly acted on wound.