WO2006026928A1 - Vulneraire et procede de fabrication et d'utilisation associe - Google Patents

Vulneraire et procede de fabrication et d'utilisation associe Download PDF

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Publication number
WO2006026928A1
WO2006026928A1 PCT/CN2005/001441 CN2005001441W WO2006026928A1 WO 2006026928 A1 WO2006026928 A1 WO 2006026928A1 CN 2005001441 W CN2005001441 W CN 2005001441W WO 2006026928 A1 WO2006026928 A1 WO 2006026928A1
Authority
WO
WIPO (PCT)
Prior art keywords
wound
sucrose
wound medicine
glucose
medical
Prior art date
Application number
PCT/CN2005/001441
Other languages
English (en)
Chinese (zh)
Inventor
Yiming Lv
Original Assignee
Yiming Lv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yiming Lv filed Critical Yiming Lv
Publication of WO2006026928A1 publication Critical patent/WO2006026928A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the invention relates to a wound medicine, a preparation method thereof and a use method. Background technique
  • the problem to be solved by the present invention is to provide a wound medicine having a function of hemostasis, anti-inflammatory and wound healing, a preparation method thereof and a use method.
  • the present invention adopts the following technical solutions:
  • the wound medicine of the present invention is a wound medicine of any dosage form which is prepared by dispensing sucrose and/or glucose as an auxiliary ingredient.
  • the concentration of sucrose and/or glucose is any concentration.
  • sucrose and/or glucose are in the form of fibers.
  • the dosage form of the present invention is a composite dressing, a wound wound medicine, a lotion, a rinsing agent, a spray, an ointment, a powder, a paint, and the like.
  • the medical composite dressing includes the medical cotton pad, the medical gauze, the medical gauze tape, the medical perforated film, the medical breathable adhesive film, the medical through-hole foam, the wound patch, the first aid belt and the like.
  • the present invention also provides a method of preparing a wound medicine comprising the steps of: heating sucrose and/or glucose, melting it, and then forming a soft fiber by techniques well known in the art. These technologies include blowing with compressed air and using a centrifugal cotton machine. The fibers are layered over the dressing and isolated with a medical PE film or waxed tissue.
  • the invention provides a method for using a wound medicine, which is suitable for all human skin Wounds, including skin cracks caused by stab wounds, sharp scratches, abrasions, impacts, bruises, bruises, wounds, bloodless people, need to squeeze out blood or add clean water to dissolve sucrose and / or glucose in the wound, The dry wound is moistened and the wound medicine is then applied directly to the wound.
  • the invention also provides a method for using a wound medicine. After the wound of the old rotted wound is washed with hydrogen peroxide, the unconformed wound is washed with the disinfectant, and then washed with the powder-type wound medicine, and the wound medicine is directly applied to the wound.
  • sucrose and glucose have hemostasis, anti-inflammatory and heal-promoting effects on human wounds.
  • the effect of sucrose and glucose is that they are not allergic to human body and have good affinity for human tissues.
  • sucrose and glucose After the high concentration of sucrose and glucose are in contact with blood, due to the principle of osmotic pressure, it can promote platelet aggregation and achieve rapid hemostasis, and form a membrane-like protective layer to prevent invasion of external bacteria, and high osmotic pressure simultaneously invades.
  • the water in the bacterial cell wall is infiltrated to achieve bacteriostatic action.
  • sucrose and glucose molecules After sucrose and glucose molecules are immersed in human tissues, they can oxidize tissues through oxidation, provide energy for cell division, increase the phagocytic ability of white blood cells, promote the growth of wound granulation tissue, and thus promote the elimination of wound inflammation and make the wound heal faster.
  • the remarkable healing effect of sucrose and glucose can reduce the formation of collagen fibers, thereby reducing the production of scar tissue. No or no antibiotics are needed.
  • the invention can be made into any dosage form suitable for treating wounds, including medical composite dressings, roll-shaped drug originals, lotions, rinsing agents, sprays, ointments, powders, paints, etc., low cost, single process, easy to use .
  • sucrose and glucose are made into saccharose fiber cotton and compounded on the dressing material, and can be made into wound patch and composite dressing of various sizes, or the saccharide fiber can be composited by a separator film and a gas permeable film to form a roll product.
  • sucrose, glucose alone or with other drugs can be used as a solution, mixed solution or powder tank, for all new and old wounds to be cleaned and washed again, in order to promote the healing of irregular wounds.
  • Rolled cotton wool with a certain width and covered with a separator film can be freely cut according to the size of the wound, and then the tearing off the barrier film to cover the wound, and then wrapped. It is easy to use, easy to apply, dissolve, absorb fast, and ensure the cleanliness of the wound. It can also be mixed with other drugs to make a powder for easy carrying.
  • the wound is opened, and the wound-type wound medicine is washed, and then the wound dressing compound dressing is applied. Wounds that injure the dermis will heal in 2 to 3 days, and those who have subcutaneous muscle tissue will eventually heal or heal in 3 to 5 days. After application with sucrose or glucose, the wound has almost no redness, swelling and pain, and the wound has no exudate and is clean. If the same wound is scrubbed with red mercury and sulfamethoxazole is applied, the wound is red and swollen for a period of time, and exudate is produced. At the same time, the wound is not clean and clean, the healing time is longer, and scarring occurs.
  • the invention has been clinically observed in 300 patient systems.
  • Cure The wound converges and heals
  • Clinical observation for 24 hours was a course of treatment, and 1 to 3 courses were observed. Among them, 2 cases were cured in the first course, 280 cases were effective, and 18 cases were ineffective. In the second course, 201 cases were cured, 87 cases were effective, and 12 cases were ineffective. In the third course of treatment, 243 cases were cured, 53 cases were effective, and 4 cases were ineffective.
  • the heater used in the following examples is an oil bath thermostat heater. All finished products should be sterilized by ethylene oxide after packaging. The package has good water resistance, good air tightness and no pressure. All sucrose and/or glucose powders are ground and sieved through a 60 mesh screen.
  • the saccharide fiber cotton prepared in Example 1 is formed into a fiber wool layer of a certain thickness on a conveyor belt, it is rolled into a cotton wool layer of a predetermined specification by a roller, and then the sugar cotton layer is composited on the dressing substrate, and the dressing substrate includes Gauze, gauze, cotton, the material can be cotton, medical non-woven, medical PE breathable film and breathable fabric or non-woven fabric with self-adhesive.
  • Composite method of sugar cotton It can be easily adsorbed on fiber fabric or non-woven fabric. For relatively smooth film or fabric which is difficult to adsorb, it can be printed with point-shaped medical adhesive or medical adhesive. Then adhere.
  • a separator may be covered, and the separator may be a plastic film or a smooth tissue paper which is waxed.
  • the ground sucrose or glucose powder is heated to 75 ° C in a water bath thermostat for 3 minutes, treated with acaricidal treatment, treated sucrose and / or glucose added to the distilled water, at room temperature of 15 - 37 ° C Stir the sucrose or glucose to a saturated solution, and allow the solution and the rinsing agent to have 10 to 50% of crystalline insoluble matter.
  • sucrose or glucose to 0.5 to 15% of medical glycerin, add an appropriate amount of distilled water, grind into a paste in a stainless steel grinder, and infuse it into a hose to seal.
  • the invention is applicable to the wounds of all skins of human bodies and other animals, including skin cracks caused by stab wounds, sharp scratches, abrasions, bruises and bruises caused by impacts, and bloody wounds need to be squeezed out of blood or wounds.
  • the untidy wound is washed with the disinfectant, and then washed with the wound medicine lotion, and the wound medicine is directly applied to the wound.
  • the wound medicine is directly applied to the wound.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur une vulnéraire contenant du saccharose et/ou du glucose en tant qu'ingrédient efficace ainsi qu'un adjuvant convenable sous n'importe quelle forme de dosage, pour l'hémostase, la déphlogisticate, et la guérison des blessures, sans antibiotique ou avec peu d'antibiotiques. L'invention se rapporte aussi au procédé de fabrication et d'utilisation associé. La vulnéraire coûte moins cher, est facile à fabriquer et pratique à utiliser.
PCT/CN2005/001441 2004-09-09 2005-09-09 Vulneraire et procede de fabrication et d'utilisation associe WO2006026928A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200410074626.3 2004-09-09
CNB2004100746263A CN1279917C (zh) 2004-09-09 2004-09-09 一种创伤药及其制备方法和使用方法

Publications (1)

Publication Number Publication Date
WO2006026928A1 true WO2006026928A1 (fr) 2006-03-16

Family

ID=34846913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2005/001441 WO2006026928A1 (fr) 2004-09-09 2005-09-09 Vulneraire et procede de fabrication et d'utilisation associe

Country Status (2)

Country Link
CN (1) CN1279917C (fr)
WO (1) WO2006026928A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114269350A (zh) * 2019-08-14 2022-04-01 林春木 局部止血组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87105864A (zh) * 1986-09-02 1988-03-23 兴和株式会社 治疗创伤的制剂
CN1124143A (zh) * 1994-06-27 1996-06-12 兴和株式会社 医治受损皮肤的粉末制剂
CN2640447Y (zh) * 2003-08-27 2004-09-15 吕益明 促愈创口贴

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87105864A (zh) * 1986-09-02 1988-03-23 兴和株式会社 治疗创伤的制剂
CN1124143A (zh) * 1994-06-27 1996-06-12 兴和株式会社 医治受损皮肤的粉末制剂
CN2640447Y (zh) * 2003-08-27 2004-09-15 吕益明 促愈创口贴

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ACTA ACADEMIAE MEDICINAE SUZHOU, vol. 15, no. 4, 1995 *
DATABASE CHINESE PHARMACEUTICAL [online] LI S.: "Clinical Observation on Treating Infective wounds with secrose gauze", Database accession no. 90005525 *
DATABASE CHINESE PHARMACEUTICAL MAI Y.: "Effects of glucose solution on the burn and Infective wounds for 20 cases", Database accession no. 96014956 *
GUIZHOU MEDICAL JOURNAL, vol. 13, no. 2, 1989 *
LI.J.: "The Treatment of pyogenicm Infection with 50%glucose solution", J. HUAIHAI MED., vol. 16, no. 3, January 1998 (1998-01-01), pages 37 *

Also Published As

Publication number Publication date
CN1628675A (zh) 2005-06-22
CN1279917C (zh) 2006-10-18

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