CN117298321A - Medical skin care dressing and preparation method thereof - Google Patents
Medical skin care dressing and preparation method thereof Download PDFInfo
- Publication number
- CN117298321A CN117298321A CN202311228845.1A CN202311228845A CN117298321A CN 117298321 A CN117298321 A CN 117298321A CN 202311228845 A CN202311228845 A CN 202311228845A CN 117298321 A CN117298321 A CN 117298321A
- Authority
- CN
- China
- Prior art keywords
- skin care
- sodium hyaluronate
- stirring
- medical skin
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 63
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 63
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 63
- 239000004094 surface-active agent Substances 0.000 claims abstract description 58
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 39
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 35
- 239000003381 stabilizer Substances 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000000758 substrate Substances 0.000 claims abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 23
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 20
- 229920000615 alginic acid Polymers 0.000 claims abstract description 20
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 20
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229920000642 polymer Polymers 0.000 claims abstract description 20
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940072056 alginate Drugs 0.000 claims abstract description 19
- 239000001913 cellulose Substances 0.000 claims abstract description 19
- 229920002678 cellulose Polymers 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 19
- 239000000049 pigment Substances 0.000 claims abstract description 19
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 10
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 10
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 10
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 10
- 238000005516 engineering process Methods 0.000 claims abstract description 10
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 10
- 239000000835 fiber Substances 0.000 claims abstract description 9
- 238000009987 spinning Methods 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 54
- 238000005303 weighing Methods 0.000 claims description 39
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 18
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 14
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical group [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 9
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 9
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 9
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 9
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- MNCGMVDMOKPCSQ-UHFFFAOYSA-M sodium;2-phenylethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=CC1=CC=CC=C1 MNCGMVDMOKPCSQ-UHFFFAOYSA-M 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 230000007480 spreading Effects 0.000 claims description 6
- 238000003892 spreading Methods 0.000 claims description 6
- 238000011084 recovery Methods 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 6
- 230000035699 permeability Effects 0.000 abstract description 4
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 abstract 1
- 229960002446 octanoic acid Drugs 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 43
- 208000027418 Wounds and injury Diseases 0.000 description 43
- 241000699670 Mus sp. Species 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 11
- 238000010521 absorption reaction Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000029663 wound healing Effects 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000006260 foam Substances 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 230000001914 calming effect Effects 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000002452 interceptive effect Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 239000000648 calcium alginate Substances 0.000 description 2
- 235000010410 calcium alginate Nutrition 0.000 description 2
- 229960002681 calcium alginate Drugs 0.000 description 2
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000000416 hydrocolloid Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- -1 silver ions Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention discloses a medical skin care dressing, which comprises the following materials in percentage: 48% -60% of cellulose polymer, 30% -50% of stabilizer, 20% -35% of sodium hyaluronate, 40% -60% of antibacterial agent, 30% -50% of alginate, 20% -45% of surfactant, 6% -8% of pigment, 30% -50% of emulsifier and 50% -60% of water, sodium hyaluronate comprises sodium hyaluronate, sodium hyaluronate and sodium hyaluronate, the stabilizer is one of hydroxyethyl cellulose, caprylic acid and benzoic acid, the medical skin care dressing is dissolved and stirred by the cellulose polymer, so that the medical skin care dressing is spread into a film, a fiber structure is obtained by adopting a spinning technology, a drug substrate is formed, the thick drug is coated on the substrate, the whole body of the medical skin care dressing forms the dressing, the substrate can be adhered to wounded parts of personnel, the substrate has good air permeability, external bacteria can be prevented while wound recovery is not affected, and the wound surface is prevented from being infected.
Description
Technical Field
The invention relates to the technical field of medical skin care dressing, in particular to a medical skin care dressing and a preparation method thereof.
Background
Skin care dressings are a special material that is applied to the skin in order to provide protection, repair and treatment of the skin, which dressings may be of single or multi-layer construction, typically made of soft, breathable, comfortable materials, intended to contact the skin and provide the desired effect of a drug, care ingredient or physical property;
the dressing is an auxiliary material used outside the main material of the article, the traditional dressing is mainly dry gauze and oil gauze, and the modern wound dressing comprises an interactive wound dressing, a calcium alginate dressing, a silver dressing, a foam dressing, a hydrocolloid dressing, a hydrogel dressing and the like;
the interactive wound dressing contains an acrylate polymer with super-effective absorption, and after being activated by ringer's solution, the ringer's solution is released continuously for 24 hours, and the wound is cleaned continuously, actively and effectively, so that the interactive wound dressing is suitable for all open wounds (narrow-depth wounds) including infectious wounds and healing stages, and especially the debridement stage is preferable;
the calcium alginate dressing is a mixture of alginic acid and calcium ions, and forms smooth gel after contacting with wound seepage and blood seepage, thereby protecting the wound surface and effectively promoting wound healing;
the silver dressing is an ideal anti-infection dressing, and silver ions can directly kill bacteria, control wound infection, accelerate wound healing and remove peculiar smell generated by the bacteria;
most of foam dressings are made of water molecule materials through foaming, a layer of polyurethane semipermeable membrane is covered on the surface of the foam dressing, the high seepage absorption capacity, the high efficient seepage management capacity and the high hydrophilic materials are adopted, the risk of wound adhesion is reduced, wound healing is promoted, and the foam pad is used for buffering external pressure;
the hydrocolloid dressing adopts a closed moisturizing principle, hydrophilic CMC particles are in contact with wound exudation, a layer of moist gel is formed on the surface of the wound, a moist environment is continuously built, and the hydrophilic CMC particles are not adhered to the wound;
the hydrogel dressing is a hydrophilic polyurethane polymer with high water content, the wettability of the wound is automatically adjusted, the hydrogel dressing has the capacity of absorbing a small amount of seepage, is not stuck to the wound and is easy to remove;
however, the existing medical skin care dressing is generally set to be in a paste form, and the paste skin dressing is generally required to be smeared on a wounded part of the skin of a person to repair the wounded part, but after the paste skin dressing is smeared on the wounded part, the dressing is easily adhered to multiple parts of a body due to mistaken touch of the person, so that ointment on the wounded part is mistakenly smeared, recovery of the wounded part is affected, the application of the ointment dressing is easy to cause the waste of the ointment due to uneven smearing, the use cost is increased, and if the skin wounded part is on a clothing part, the clothing of the person is easy to be adhered on the wounded part, and external bacteria are easy to reach the wounded part through the ointment to cause infection of the wound, so that the medical skin care dressing is unfavorable for use; the existing part of medical skin care dressing is provided with a disinfection cloth coated with a wound to protect the affected part from infection, but the skin dressing has poor air permeability, and the affected part cannot be well moisturized, repaired and the like, so that the healing period of the affected part is longer, the size of the dressing is smaller, the dressing is generally suitable for slight wounds, the application range is limited, and therefore, the medical skin care dressing and the preparation method thereof are provided.
Disclosure of Invention
The invention aims to provide a medical skin care dressing and a preparation method thereof, which are used for solving the problems in the background technology.
In order to achieve the purpose, the invention provides a medical skin care dressing which comprises the following materials in percentage: 48% -60% of cellulose polymer, 30% -50% of stabilizer, 20% -35% of sodium hyaluronate, 40% -60% of antibacterial agent, 30% -50% of alginate, 20% -45% of surfactant, 6% -8% of pigment, 30% -50% of emulsifier and 50% -60% of water.
Preferably, the sodium hyaluronate comprises high molecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate, and can absorb and maintain moisture on the surface of skin through the sodium hyaluronate, so that the sodium hyaluronate has the effects of filling fine lines and wrinkles on a wound surface, adsorbing and damaging the skin, resisting inflammation and calming, and simultaneously has the effect of promoting collagen generation, and is more beneficial to recovery of the wound surface of the skin.
Preferably, the stabilizer is one of hydroxyethyl cellulose, octanoic acid and benzoic acid, and the stabilizer can maintain the physical property of the product, prevent component separation and have certain antibacterial and antiseptic properties.
Preferably, the emulsifier is one or more of glyceryl acteate, sodium dodecyl sulfate and cocamidopropyl betaine, and the concentration of the liquid medicament can be enhanced by the emulsifier, so that the adhesiveness of the dressing can be enhanced.
Preferably, the surfactant is one of sodium styrene sulfonate, amino acid surfactant and sodium polyethyleneglycol stearyl alcohol ether sulfate, and the surfactant is added into the dressing, so that the moisture absorption performance of the scene can be enhanced, a moisture absorption film is formed on the surface of the dressing, the liquid discharged from the wound surface is effectively absorbed, and the recovery of the wound is promoted.
Preferably, the antibacterial agent is silver ion antibacterial agent, and the silver ion antibacterial agent can have a good antibacterial effect, so that the wound surface is effectively prevented from being infected.
A method of preparing a medical skin care dressing according to any one of the preceding claims, comprising the steps of:
step one: weighing two containers according to a specified weighing amount, and respectively placing the two containers for standby;
step two: placing the cellulose polymer in a container in the first step, stirring and dissolving, spreading into a film, and finally obtaining a fiber structure by adopting a spinning technology to form a base material;
step three: sequentially weighing sodium hyaluronate, stabilizer, antibacterial agent, alginate and pigment according to preset amount;
step four: sequentially adding the weighed components in the third step into another container containing water in the first step;
step five: stirring the mixture easy to be in the fourth step, and standing after stirring for a period of time;
step six: stirring the solution obtained in the fifth step again to ensure the full mixing of the components in the container;
step seven: weighing a certain amount of surfactant according to a specified rule, adding the weighed surfactant into the container in the step six, and stirring to dissolve the surfactant;
step eight: weighing the emulsifier according to the regulation, adding the emulsifier into the container in the step seven, and stirring;
step nine: uniformly coating the medicament obtained in the step eight on the surface of the substrate obtained in the step one;
step ten: the substrate in step nine is cut or trimmed to the desired dressing size.
Preferably, the stirring time in the fifth step is 20-30 minutes, and the standing time is 8-10 hours.
Preferably, in the step ten, a plurality of dressing sizes are provided according to different parts of the skin.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, the cellulose polymer is dissolved and stirred to be spread into a film, a fiber structure is obtained by adopting a spinning technology, a medicine substrate is formed, and thick medicine is coated on the substrate to integrally form a dressing, so that the substrate can be adhered to a wounded part of a person, the substrate has good air permeability, external bacteria can be blocked while wound recovery is not influenced, and the wound surface of the wound is prevented from being infected;
2. the invention changes the traditional skin dressing in a liquid paste state, and effectively avoids the waste of the traditional paste dressing caused by the adhesion of multiple parts of the body due to the false touch of personnel;
3. the dressing with the base material is cut into various sizes, so that the dressing can adapt to wounds with different wound sizes at various parts of the skin, and the application range is enlarged;
4. the invention can keep the physical property of the product, prevent the separation of components and have certain antibacterial and antiseptic properties, and can absorb and keep the moisture on the surface of the skin through the sodium hyaluronate, thereby having the effects of filling fine lines and wrinkles on the wound surface, adsorbing damaged skin, resisting inflammation and calming, and simultaneously having the effect of promoting the generation of collagen, thereby being more beneficial to the recovery of the wound surface of the skin;
5. the silver ion antibacterial agent has a good antibacterial effect, and effectively avoids the infection of wound surfaces;
6. according to the invention, the surface active agent is added into the dressing, so that the moisture absorption performance of a scene can be enhanced, a moisture absorption film is formed on the surface of the dressing, the liquid discharged from the wound surface is effectively absorbed, and the recovery of the wound is quickened.
Detailed Description
The invention provides a technical scheme that: a medical skin care dressing comprising the following materials in percent: 48% -60% of cellulose polymer, 30% -50% of stabilizer, 20% -35% of sodium hyaluronate, 40% -60% of antibacterial agent, 30% -50% of alginate, 20% -45% of surfactant, 6% -8% of pigment, 30% -50% of emulsifier and 50% -60% of water.
The sodium hyaluronate comprises high molecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate, can absorb and maintain moisture on the surface of skin through the sodium hyaluronate, has the effects of filling fine lines and wrinkles on a wound surface, adsorbing damaged skin, resisting inflammation and calming, and simultaneously has the effect of promoting collagen generation, and is more beneficial to recovery of the wound surface of the skin.
The stabilizer is one of hydroxyethyl cellulose, octanoic acid and benzoic acid, and can keep the physical property of the product, prevent component separation and have certain antibacterial and antiseptic properties.
The emulsifier is one or more of the following components of the glyceryl acteate, sodium dodecyl sulfate and cocamidopropyl betaine, and can enhance the concentration of the liquid medicament and enhance the adhesiveness of the dressing.
The surface active agent is one of sodium styrene sulfonate, amino acid surface active agent and polyethylene glycol stearyl alcohol ether sodium sulfate, and the surface active agent is added into the dressing, so that the moisture absorption performance of the scene can be enhanced, a moisture absorption film is formed on the surface of the dressing, the discharged liquid of the wound surface is effectively absorbed, and the recovery of the wound is quickened.
The antibacterial agent is silver ion antibacterial agent, and can play a good role in antibacterial effect, so that the wound surface is effectively prevented from being infected.
A method of preparing a medical skin care dressing according to any one of the preceding claims, comprising the steps of:
step one: weighing two containers according to a specified weighing amount, and respectively placing the two containers for standby;
step two: placing the cellulose polymer in a container in the first step, stirring and dissolving, spreading into a film, and finally obtaining a fiber structure by adopting a spinning technology to form a base material;
step three: sequentially weighing sodium hyaluronate, stabilizer, antibacterial agent, alginate and pigment according to preset amount;
step four: sequentially adding the weighed components in the third step into another container containing water in the first step;
step five: stirring the mixture easy to be in the fourth step, and standing after stirring for a period of time;
step six: stirring the solution obtained in the fifth step again to ensure the full mixing of the components in the container;
step seven: weighing a certain amount of surfactant according to a specified rule, adding the weighed surfactant into the container in the step six, and stirring to dissolve the surfactant;
step eight: weighing the emulsifier according to the regulation, adding the emulsifier into the container in the step seven, and stirring;
step nine: uniformly coating the medicament obtained in the step eight on the surface of the substrate obtained in the step one;
step ten: the substrate in step nine is cut or trimmed to the desired dressing size.
The stirring time in the step five is 20-30 minutes, and the standing time is 8-10 hours.
In the step ten, a plurality of dressing sizes are arranged according to different parts of the skin.
Example 1
A medical skin care dressing comprising the following materials in percent: 48% of cellulose polymer, 30% of stabilizer, 20% of sodium hyaluronate, 40% of antibacterial agent, 30% of alginate, 20% of surfactant, 6% of pigment, 30% of emulsifier and 54% of water.
The sodium hyaluronate comprises high molecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate.
The stabilizer is one of hydroxyethyl cellulose, octanoic acid and benzoic acid.
The emulsifier is one or more of glyceryl aclacinate, sodium dodecyl sulfate and cocamidopropyl betaine.
The surfactant is one of sodium styrene sulfonate, amino acid surfactant and sodium polyethylene glycol stearyl alcohol ether sulfate.
The antibacterial agent is silver ion antibacterial agent.
A method of preparing a medical skin care dressing according to any one of the preceding claims, comprising the steps of:
step one: weighing two containers according to a specified weighing amount, and respectively placing the two containers for standby;
step two: placing the cellulose polymer in a container in the first step, stirring and dissolving, spreading into a film, and finally obtaining a fiber structure by adopting a spinning technology to form a base material;
step three: sequentially weighing sodium hyaluronate, stabilizer, antibacterial agent, alginate and pigment according to preset amount;
step four: sequentially adding the weighed components in the third step into another container containing water in the first step;
step five: stirring the mixture easy to be in the fourth step, and standing after stirring for a period of time;
step six: stirring the solution obtained in the fifth step again to ensure the full mixing of the components in the container;
step seven: weighing a certain amount of surfactant according to a specified rule, adding the weighed surfactant into the container in the step six, and stirring to dissolve the surfactant;
step eight: weighing the emulsifier according to the regulation, adding the emulsifier into the container in the step seven, and stirring;
step nine: uniformly coating the medicament obtained in the step eight on the surface of the substrate obtained in the step one;
step ten: the substrate in step nine is cut or trimmed to the desired dressing size.
The stirring time in the step five is 20-30 minutes, and the standing time is 8-10 hours.
In the step ten, a plurality of dressing sizes are arranged according to different parts of the skin.
Example 2
A medical skin care dressing comprising the following materials in percent: 50% of cellulose polymer, 40% of stabilizer, 30% of sodium hyaluronate, 45 of antibacterial agent, 40 of alginate, 28% of surfactant, 7% of pigment, 40% of emulsifier and 55% of water.
The sodium hyaluronate comprises high molecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate.
The stabilizer is one of hydroxyethyl cellulose, octanoic acid and benzoic acid.
The emulsifier is one or more of glyceryl aclacinate, sodium dodecyl sulfate and cocamidopropyl betaine.
The surfactant is one of sodium styrene sulfonate, amino acid surfactant and sodium polyethylene glycol stearyl alcohol ether sulfate.
The antibacterial agent is silver ion antibacterial agent.
A method of preparing a medical skin care dressing according to any one of the preceding claims, comprising the steps of:
step one: weighing two containers according to a specified weighing amount, and respectively placing the two containers for standby;
step two: placing the cellulose polymer in a container in the first step, stirring and dissolving, spreading into a film, and finally obtaining a fiber structure by adopting a spinning technology to form a base material;
step three: sequentially weighing sodium hyaluronate, stabilizer, antibacterial agent, alginate and pigment according to preset amount;
step four: sequentially adding the weighed components in the third step into another container containing water in the first step;
step five: stirring the mixture easy to be in the fourth step, and standing after stirring for a period of time;
step six: stirring the solution obtained in the fifth step again to ensure the full mixing of the components in the container;
step seven: weighing a certain amount of surfactant according to a specified rule, adding the weighed surfactant into the container in the step six, and stirring to dissolve the surfactant;
step eight: weighing the emulsifier according to the regulation, adding the emulsifier into the container in the step seven, and stirring;
step nine: uniformly coating the medicament obtained in the step eight on the surface of the substrate obtained in the step one;
step ten: the substrate in step nine is cut or trimmed to the desired dressing size.
The stirring time in the step five is 20-30 minutes, and the standing time is 8-10 hours.
In the step ten, a plurality of dressing sizes are arranged according to different parts of the skin.
Example 3
A medical skin care dressing comprising the following materials in percent: 48% -60% of cellulose polymer, 50% of stabilizer, 35% of sodium hyaluronate, 60% of antibacterial agent, 50% of alginate, 45% of surfactant, 8% of pigment, 50% of emulsifier and 60% of water.
The sodium hyaluronate comprises high molecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate.
The stabilizer is one of hydroxyethyl cellulose, octanoic acid and benzoic acid.
The emulsifier is one or more of glyceryl aclacinate, sodium dodecyl sulfate and cocamidopropyl betaine.
The surfactant is one of sodium styrene sulfonate, amino acid surfactant and sodium polyethylene glycol stearyl alcohol ether sulfate.
The antibacterial agent is silver ion antibacterial agent.
A method of preparing a medical skin care dressing according to any one of the preceding claims, comprising the steps of:
step one: weighing two containers according to a specified weighing amount, and respectively placing the two containers for standby;
step two: placing the cellulose polymer in a container in the first step, stirring and dissolving, spreading into a film, and finally obtaining a fiber structure by adopting a spinning technology to form a base material;
step three: sequentially weighing sodium hyaluronate, stabilizer, antibacterial agent, alginate and pigment according to preset amount;
step four: sequentially adding the weighed components in the third step into another container containing water in the first step;
step five: stirring the mixture easy to be in the fourth step, and standing after stirring for a period of time;
step six: stirring the solution obtained in the fifth step again to ensure the full mixing of the components in the container;
step seven: weighing a certain amount of surfactant according to a specified rule, adding the weighed surfactant into the container in the step six, and stirring to dissolve the surfactant;
step eight: weighing the emulsifier according to the regulation, adding the emulsifier into the container in the step seven, and stirring;
step nine: uniformly coating the medicament obtained in the step eight on the surface of the substrate obtained in the step one;
step ten: the substrate in step nine is cut or trimmed to the desired dressing size.
The stirring time in the step five is 20-30 minutes, and the standing time is 8-10 hours.
In the step ten, a plurality of dressing sizes are arranged according to different parts of the skin.
Comparative example 1
A medical skin care dressing comprising the following materials in percent: 48% of cellulose polymer, 30% of stabilizer, 20% of sodium hyaluronate, 40% of antibacterial agent, 30% of alginate, 20% of surfactant, 6% of pigment, 30% of emulsifier and 54% of water.
The sodium hyaluronate comprises high molecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate.
The stabilizer is one of hydroxyethyl cellulose, octanoic acid and benzoic acid.
The emulsifier is one or more of glyceryl aclacinate, sodium dodecyl sulfate and cocamidopropyl betaine.
The surfactant is one of sodium styrene sulfonate, amino acid surfactant and sodium polyethylene glycol stearyl alcohol ether sulfate.
The antibacterial agent is silver ion antibacterial agent.
A method of preparing a medical skin care dressing according to any one of the preceding claims, comprising the steps of:
step one: taking a container, weighing a proper amount of water according to a specified rule, and placing the water in the container for standby;
step two: sequentially weighing sodium hyaluronate, stabilizer, antibacterial agent, alginate and pigment according to preset amount;
step three: sequentially adding the weighed components in the second step into the container filled with water in the first step;
step four: stirring the mixture easy to be in the third step, and standing after stirring for a period of time;
step five: stirring the solution obtained in the step four again to ensure the full mixing of the components in the container;
step six: weighing a certain amount of surfactant according to a specified rule, adding the weighed surfactant into the container in the fifth step, and stirring to dissolve the surfactant;
step seven: the emulsifier is weighed according to the specification, added into the container in the step six and then stirred.
Comparative example 2
A medical skin care dressing comprising the following materials in percent: 50% of cellulose polymer, 40% of stabilizer, 30% of sodium hyaluronate, 45 of antibacterial agent, 40 of alginate, 28% of surfactant, 7% of pigment, 40% of emulsifier and 55% of water.
The sodium hyaluronate comprises high molecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate.
The stabilizer is one of hydroxyethyl cellulose, octanoic acid and benzoic acid.
The emulsifier is one or more of glyceryl aclacinate, sodium dodecyl sulfate and cocamidopropyl betaine.
The surfactant is one of sodium styrene sulfonate, amino acid surfactant and sodium polyethylene glycol stearyl alcohol ether sulfate.
The antibacterial agent is silver ion antibacterial agent.
A method of preparing a medical skin care dressing according to any one of the preceding claims, comprising the steps of:
step one: taking a container, weighing a proper amount of water according to a specified rule, and placing the water in the container for standby;
step two: sequentially weighing sodium hyaluronate, stabilizer, antibacterial agent, alginate and pigment according to preset amount;
step three: sequentially adding the weighed components in the second step into the container filled with water in the first step;
step four: stirring the mixture easy to be in the third step, and standing after stirring for a period of time;
step five: stirring the solution obtained in the step four again to ensure the full mixing of the components in the container;
step six: weighing a certain amount of surfactant according to a specified rule, adding the weighed surfactant into the container in the fifth step, and stirring to dissolve the surfactant;
step seven: the emulsifier is weighed according to the specification, added into the container in the step six and then stirred.
Comparative example 3
A medical skin care dressing comprising the following materials in percent: 48% -60% of cellulose polymer, 50% of stabilizer, 35% of sodium hyaluronate, 60% of antibacterial agent, 50% of alginate, 45% of surfactant, 8% of pigment, 50% of emulsifier and 60% of water.
The sodium hyaluronate comprises high molecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate.
The stabilizer is one of hydroxyethyl cellulose, octanoic acid and benzoic acid.
The emulsifier is one or more of glyceryl aclacinate, sodium dodecyl sulfate and cocamidopropyl betaine.
The surfactant is one of sodium styrene sulfonate, amino acid surfactant and sodium polyethylene glycol stearyl alcohol ether sulfate.
The antibacterial agent is silver ion antibacterial agent.
A method of preparing a medical skin care dressing according to any one of the preceding claims, comprising the steps of:
step one: taking a container, weighing a proper amount of water according to a specified rule, and placing the water in the container for standby;
step two: sequentially weighing sodium hyaluronate, stabilizer, antibacterial agent, alginate and pigment according to preset amount;
step three: sequentially adding the weighed components in the second step into the container filled with water in the first step;
step four: stirring the mixture easy to be in the third step, and standing after stirring for a period of time;
step five: stirring the solution obtained in the step four again to ensure the full mixing of the components in the container;
step six: weighing a certain amount of surfactant according to a specified rule, adding the weighed surfactant into the container in the fifth step, and stirring to dissolve the surfactant;
step seven: the emulsifier is weighed according to the specification, added into the container in the step six and then stirred.
The skin care dressings prepared in example 1, example 2, example 3 and comparative examples 1, comparative examples 2, comparative example 3 were subjected to wound healing performance testing, and specific procedures are as follows:
(1) The experimental animals adopt mice with uniform age, weight and sex, the mice are respectively subjected to the last 3 days, 6 days, 12 days and 20 days, 6 animals are prepared each time, the backs of the mice are subjected to the same-area unhairing treatment, the unhairing mice are subjected to the anesthesia treatment, and after the anesthesia treatment is finished, the mice are scalded for 10 seconds by adopting a water bath with the temperature of 85 ℃ to enable the positions of the areas of the backs of the mice to be subjected to the same-level scalding (detection of a disease detection slice);
(2) In a specific operation, the medical skin dressing prepared in the example 1, the example 2 and the example 3 is stuck to the scalded part of the back of the mouse; the medical skin paste dressings prepared in comparative examples 1, 2 and 3 are coated on the scalded parts of the backs of the mice, used three times a day and used for three days continuously, and the wounded condition of each mouse is observed after three days;
(3) The mice using the medicines for three days are sequentially and continuously used for 3 days, and the injury situation of the back of each mouse is observed;
(4) Continuously using the same drug for 6 days by the mice using the six-day drug, and observing the wound healing condition of the back of the mice;
(5) The mice after 12 days of medicine use are continuously used for 8 days, and the wound condition of the back of each mouse is observed;
the test conditions are shown in the following table:
wound healing conditions of medical skin care dressing obtained in examples 1 to 3 and comparative examples 1 to 3
In the operation process of the comparative example, the medical skin care dressing of the comparative example is used in a larger amount under the condition of the same amount as the example due to the pasty state of the smearing type, and the wound surface of the comparative example is infected due to the movement of a mouse in the use process.
Conclusion: according to the invention, the cellulose polymer is dissolved and stirred to be spread into a film, a fiber structure is obtained by adopting a spinning technology, a medicine substrate is formed, and thick medicine is coated on the substrate to integrally form a dressing, so that the substrate can be adhered to a wounded part of a person, the substrate has good air permeability, external bacteria can be blocked while wound recovery is not influenced, the condition that a wound surface is infected is avoided, the traditional liquid paste-state skin dressing is changed, and the condition that the traditional paste-state dressing is adhered to multiple parts of the body due to false touch of the person is effectively avoided.
Furthermore, the terms "first," "second," "third," "fourth," and the like are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated, whereby features defining "first," "second," "third," "fourth" may explicitly or implicitly include at least one such feature.
In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "configured," "connected," "secured," "screwed," and the like are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intermediaries, or in communication with each other or in interaction with each other, unless explicitly defined otherwise, the meaning of the terms described above in this application will be understood by those of ordinary skill in the art in view of the specific circumstances.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. A medical skin care dressing, characterized by comprising the following materials in percentage: 48% -60% of cellulose polymer, 30% -50% of stabilizer, 20% -35% of sodium hyaluronate, 40% -60% of antibacterial agent, 30% -50% of alginate, 20% -45% of surfactant, 6% -8% of pigment, 30% -50% of emulsifier and 50% -60% of water.
2. A medical skin care dressing according to claim 1, wherein: the sodium hyaluronate comprises high molecular sodium hyaluronate, medium molecular sodium hyaluronate and small molecular sodium hyaluronate.
3. A medical skin care dressing according to claim 1, wherein: the stabilizer is one of hydroxyethyl cellulose, octanoic acid and benzoic acid.
4. A medical skin care dressing according to claim 1, wherein: the emulsifier is one or more of glyceryl aclacinate, sodium dodecyl sulfate and cocamidopropyl betaine.
5. A medical skin care dressing according to claim 1, wherein: the surfactant is one of sodium styrene sulfonate, amino acid surfactant and sodium polyethylene glycol stearyl alcohol ether sulfate.
6. A medical skin care dressing according to claim 1, wherein: the antibacterial agent is silver ion antibacterial agent.
7. A method of preparing a medical skin care dressing according to any one of claims 1 to 6, comprising the steps of:
step one: weighing two containers according to a specified weighing amount, and respectively placing the two containers for standby;
step two: placing the cellulose polymer in a container in the first step, stirring and dissolving, spreading into a film, and finally obtaining a fiber structure by adopting a spinning technology to form a base material;
step three: sequentially weighing sodium hyaluronate, stabilizer, antibacterial agent, alginate and pigment according to preset amount;
step four: sequentially adding the weighed components in the third step into another container containing water in the first step;
step five: stirring the mixture easy to be in the fourth step, and standing after stirring for a period of time;
step six: stirring the solution obtained in the fifth step again to ensure the full mixing of the components in the container;
step seven: weighing a certain amount of surfactant according to a specified rule, adding the weighed surfactant into the container in the step six, and stirring to dissolve the surfactant;
step eight: weighing the emulsifier according to the regulation, adding the emulsifier into the container in the step seven, and stirring;
step nine: uniformly coating the medicament obtained in the step eight on the surface of the substrate obtained in the step one;
step ten: the substrate in step nine is cut or trimmed to the desired dressing size.
8. A method of preparing a medical skin care dressing according to claim 7, wherein: the stirring time in the step five is 20-30 minutes, and the standing time is 8-10 hours.
9. A method of preparing a medical skin care dressing according to claim 7, wherein: in the step ten, a plurality of dressing sizes are arranged according to different parts of the skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311228845.1A CN117298321A (en) | 2023-09-22 | 2023-09-22 | Medical skin care dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311228845.1A CN117298321A (en) | 2023-09-22 | 2023-09-22 | Medical skin care dressing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117298321A true CN117298321A (en) | 2023-12-29 |
Family
ID=89259591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311228845.1A Pending CN117298321A (en) | 2023-09-22 | 2023-09-22 | Medical skin care dressing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117298321A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1721004A (en) * | 2004-07-15 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | Biological active antibiotic dressing |
| US20070053960A1 (en) * | 2005-08-31 | 2007-03-08 | Board Of Regents, The University Of Texas System | Multiribbon nanocellulose as a matrix for wound healing |
| CN102670600A (en) * | 2011-03-12 | 2012-09-19 | 赵海静 | Medicinal product for inhibiting scar and promoting wound healing, and preparation method and application of medicinal product |
| CN108187122A (en) * | 2018-03-16 | 2018-06-22 | 苏州凌科特新材料有限公司 | A kind of preparation method of ventilative imbibition swelling medical dressing |
| CN108686255A (en) * | 2018-05-24 | 2018-10-23 | 广州芬森医学科技有限公司 | It is a kind of to prevent the biological dressing and preparation method thereof that scar is formed |
| CN114601959A (en) * | 2020-11-23 | 2022-06-10 | 山东融元康医疗科技有限公司 | Medical skin care dressing and preparation method and application thereof |
-
2023
- 2023-09-22 CN CN202311228845.1A patent/CN117298321A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1721004A (en) * | 2004-07-15 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | Biological active antibiotic dressing |
| US20070053960A1 (en) * | 2005-08-31 | 2007-03-08 | Board Of Regents, The University Of Texas System | Multiribbon nanocellulose as a matrix for wound healing |
| CN102670600A (en) * | 2011-03-12 | 2012-09-19 | 赵海静 | Medicinal product for inhibiting scar and promoting wound healing, and preparation method and application of medicinal product |
| CN108187122A (en) * | 2018-03-16 | 2018-06-22 | 苏州凌科特新材料有限公司 | A kind of preparation method of ventilative imbibition swelling medical dressing |
| CN108686255A (en) * | 2018-05-24 | 2018-10-23 | 广州芬森医学科技有限公司 | It is a kind of to prevent the biological dressing and preparation method thereof that scar is formed |
| CN114601959A (en) * | 2020-11-23 | 2022-06-10 | 山东融元康医疗科技有限公司 | Medical skin care dressing and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108014366B (en) | Marine biological material composite hydrogel dressing and preparation method thereof | |
| CN106492260B (en) | Alginate-based hydrogel dressing and preparation method thereof | |
| CN103520764B (en) | Functional dressing, and preparation method and application thereof | |
| CN111228040A (en) | Absorbable anti-adhesion dressing and preparation method thereof | |
| RU2422133C1 (en) | Hydrophylic gel, method of its obtaining (versions), wound covering and based on it bandage means | |
| EA010316B1 (en) | Wound dressing based on microbial-derived cellulose, use thereof and kit containing thereof | |
| CN110507845A (en) | Biological composite ventilating dressing and preparation method thereof | |
| Khorasani et al. | The effects of Aloe Vera cream on split-thickness skin graft donor site management: a randomized, blinded, placebo-controlled study | |
| JP6290184B2 (en) | Wound dressing | |
| WO2023198086A1 (en) | Antibacterial healing-promoting functionalized dressing and preparation method therefor | |
| CN109331215A (en) | A kind of medical antibacterial sponge and preparation method thereof | |
| CN106110369B (en) | A kind of medical composite type hyaluronic acid dressing and preparation method thereof | |
| CN110859989B (en) | Liquid band-aid and preparation method thereof | |
| KR100923122B1 (en) | Preparation for wound healing and prevention of bandage adhesion to the wound | |
| CN106139239A (en) | Full-service fluid dressing and preparation method thereof | |
| CN110876814A (en) | Liquid band-aid rich in antibacterial peptide and preparation method thereof | |
| CN104984383A (en) | Novel hydrogel dressing for treating burn wound and preparation method thereof | |
| CZ302380B6 (en) | Dry substance of hydrogel to cover wounds and process for preparing thereof | |
| Bülbül et al. | Traditional and advanced wound dressings: physical characterization and desirable properties for wound healing | |
| CN117298321A (en) | Medical skin care dressing and preparation method thereof | |
| CN111481733B (en) | Biological medicine wound surface dressing | |
| CN114225093A (en) | Antibacterial dressing with composite function and preparation method thereof | |
| CN109010907B (en) | A kind of functionality Wound-protection liquid body dressing and preparation method thereof | |
| KR20040051130A (en) | Method for the preparation of hydrogels for wound dressings | |
| KR101242573B1 (en) | Preparing method of Gel for treatment an ulcer including a honey and Gel for treatment an ulcer thereby |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |