CN108187122A - A kind of preparation method of ventilative imbibition swelling medical dressing - Google Patents
A kind of preparation method of ventilative imbibition swelling medical dressing Download PDFInfo
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- CN108187122A CN108187122A CN201810217235.4A CN201810217235A CN108187122A CN 108187122 A CN108187122 A CN 108187122A CN 201810217235 A CN201810217235 A CN 201810217235A CN 108187122 A CN108187122 A CN 108187122A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention discloses a kind of preparation methods of ventilative imbibition swelling medical dressing, the technique is by cellulose gum, polylactic acid, hydroxypropyl methyl cellulose, the main raw material(s)s such as hydroxyethyl cellulose are boiled by alkaline process, evaporation, it filters, washing, it is dry, the processing steps such as ball milling prepare the base material of dressing, then by laruyl alcohol sodium sulfovinate, sodium chloride, sucrose fatty ester, alkaline pectase, palmitic acid, Antiradon, pyrovinic acid, the raw materials such as disodium hydrogen phosphate are respectively by stirring and evenly mixing, vacuum defoamation, wet spinning, measure spinneret, coagulating bath, it stretches, sizing, weaving, rinsing, activation, damp and hot high temperature steam treatment, dehydration is dried, open-width, drying and etc. ventilative imbibition swelling medical dressing is prepared.The ventilative imbibition swelling medical dressing being prepared, permeability is good, water imbibition is strong, imbibition swelling function is strong, can meet it is medical it is medical in a variety of demands.
Description
Technical field
The present invention relates to this technical fields of medical material, are related specifically to the preparation side of ventilative imbibition swelling medical dressing
Method.
Background technology
Wound is a kind of integrality to human skin and successional destruction.In daily life, there are many type of wound,
Including the burn as caused by the factors such as machinery, electricity, heat, chemistry and due to the morphogenetic chronic trauma of the physiological disease of patient.Always
Often there are the chronic wounds such as the bedsore caused by poor circulation, ulcer in Nian Renzhong.In recent years, with population in the world
The trend substantially increased is presented in the whole world, particularly American-European countries for aging, chronic ulcerative wound.Medical dressing is a kind of
Flap coverage, the material of assist wound healing.From the 1980's so far, with advances in technology with people to wound healing process
With the deep understanding of wound care process, many novel materials are used in the preparation of medical dressing.It is medical in high-tech
In the market, the more material of application includes calcium alginate fibre, polyurethane film and foam, hydrocolloid, water-setting at present for dressing
The materials such as glue, carboxymethyl cellulose.Research shows that bacteria cellulose under moisture conditions high mechanical strength, to liquid, gas and electrolysis
Object has good permeability, good with skin-friendliness, nonirritant, can effectively relieve pain, and absorbs the liquid of wound exudation, promotees
Into the quick healing of wound, be conducive to skin histology growth.Research shows that cellulosic material mechanical strength under moisture conditions
Height has liquid, gas and electrolyte good permeability, is good with skin-friendliness, nonirritant, can effectively relieve pain, and absorbs
The liquid of wound exudation, promotes the quick healing of wound, is conducive to skin histology growth.
Invention content
According to above-mentioned technical background data, the invention discloses the preparation method of ventilative imbibition swelling medical dressing, the works
The main raw material(s)s such as cellulose gum, polylactic acid, hydroxypropyl methyl cellulose, hydroxyethyl cellulose by alkaline process are boiled, steamed by skill
The processing steps such as hair, suction filtration, washing, drying, ball milling prepare the base material of dressing, then by laruyl alcohol sodium sulfovinate, sodium chloride, sugarcane
The raw materials such as sugar fatty acid ester, alkaline pectase, palmitic acid, Antiradon, pyrovinic acid, disodium hydrogen phosphate are mixed by stirring respectively
Even, vacuum defoamation, wet spinning, metering spinneret, coagulating bath, stretching, sizing, weaving, rinsing, activation, at damp and hot high-temperature steam
Reason, dehydration are dried, open-width, drying and etc. ventilative imbibition swelling medical dressing is prepared.The ventilative imbibition being prepared is molten
Swollen medical dressing, permeability is good, water imbibition is strong, imbibition swelling function is strong, can meet medical treatment it is medical in a variety of demands.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of preparation method of ventilative imbibition swelling medical dressing, includes the following steps：
（1）By 9-15 parts of cellulose gum, 4-9 parts of polylactic acid, 12-18 parts of hydroxypropyl methyl cellulose, hydroxyethyl cellulose 15-20
Part is boiled 35 minutes after mixing with 10% sodium bicarbonate solution, and then mixed liquor is transferred on Rotary Evaporators, and rotation is steamed
About 20min is sent out to without apparent bubble and after there is white suspension particle, suspension is injected in Suction filtration device and is filtered, filters process
In be slowly added 100ml ethyl alcohol, washed filtering is to neutrality again for obtained solid, then through 65 DEG C of vacuum drying, ball grinds
End, it is spare；
（2）By step（1）In 20-25 parts of powder, 3-6 parts of laruyl alcohol sodium sulfovinate, 1-5 parts of sodium chloride, sucrose fatty ester
2-4 parts, 3-5 parts of alkaline pectase, 2-6 parts of palmitic acid, 1-3 parts of Antiradon, 3-7 parts of pyrovinic acid, disodium hydrogen phosphate 2-5
Part, carry out vacuum defoamation after being stirred, then add in wet-spinning frame in, by measure pump-metered, spinning head extrude after
It is precipitated in coagulating bath and forms fiber filaments, washing, drying, the coagulating bath is methyltriethoxysilane, citric acid, 1- fourths
The mixing alcoholic solution of base -3- methylimidazolium chlorides, glacial acetic acid, wherein Ethoxysilane, citric acid, 1- butyl -3- methyl chlorides
Imidazoles, glacial acetic acid molar ratio be 5:18:3:10, it handles to obtain primary dressing using stretching, sizing, weaving；
（3）By step（2）Obtained primary dressing is immersed in the hot water storgae of desizing, scouring and bleaching combined machine, sets bath raio as 1:27, first use
75-80 DEG C of water cleans 40-42 minutes, then water temperature is risen to 90-95 DEG C, adds in 2-6 parts of activator, cleans 30-45 minutes；
（4）By step（3）Obtained dressing is soaked in by propylene glycol alginate, ethylenediamine, triethylene tetramine, mannitol, nothing
Water-ethanol, water are according to mass ratio 7:3:2:2:9:In the mixed liquor of 100 compositions, damp and hot high-temperature vapor processing is carried out, then will
It is neutral that processed fabric, which is washed with clear water to surface, dries to obtain after-treatment dressing through dehydration；
（5）By obtained after-treatment dressing through scutcher open-width, then drying machine drying and processing 20- at 105-110 DEG C
40 minutes to get finished product.
Preferably, the step（1）In rotary evaporation parameter for 42-45 DEG C of temperature, pressure -0.05MPa.
Preferably, the step（2）In vacuum pressure be 2*10-8Pa。
Preferably, the step（2）In drying carried out by radiating, contacting heating, temperature is 110-115 DEG C.
Preferably, the step（3）In one kind in oxalic acid, sodium carbonate, copper sulphate, sodium citrate of activator or
It is several.
Preferably, the step（4）In high-temperature vapor temperature be 1000-1100 DEG C.
Compared with prior art, the present invention advantage is：
（1）The preparation method of the ventilative imbibition swelling medical dressing of the present invention is by cellulose gum, polylactic acid, hydroxypropyl methyl fiber
The processing steps systems such as the main raw material(s)s such as element, hydroxyethyl cellulose are boiled by alkaline process, evaporated, filtering, washing, drying, ball milling
The base material of standby dressing, then by laruyl alcohol sodium sulfovinate, sodium chloride, sucrose fatty ester, alkaline pectase, palmitic acid, ethamine
The raw materials such as thiocarbamide, pyrovinic acid, disodium hydrogen phosphate pass through respectively to be stirred and evenly mixed, vacuum defoamation, wet spinning, metering spinneret, coagulates
Gu bath, stretching, sizing, weaving, rinsing, activation, damp and hot high temperature steam treatment, dehydration dry, open-width, drying and etc. be prepared into
Medical dressing is swollen to ventilative imbibition.The ventilative imbibition swelling medical dressing being prepared, permeability is good, water imbibition is strong,
Imbibition swelling function is strong, can meet medical treatment it is medical in a variety of demands.
（2）The ventilative imbibition swelling medical dressing raw material of the present invention is easy to get, is simple for process, is transported suitable for heavy industrialization
With highly practical.
Specific embodiment
The technical solution of invention is described in detail with reference to specific embodiment.
Embodiment 1
（1）9 parts of cellulose gum, 4 parts of polylactic acid, 12 parts of hydroxypropyl methyl cellulose, 15 parts of hydroxyethyl cellulose are uniformly mixed
It is boiled 35 minutes with 10% sodium bicarbonate solution, mixed liquor is transferred on Rotary Evaporators afterwards then, rotary evaporation parameter is temperature
42 DEG C, pressure -0.05MPa of degree, rotary evaporation about 20min is extremely without apparent bubble and after there is white suspension particle, by suspension
It being filtered in injection Suction filtration device, 100ml ethyl alcohol is slowly added during filtering, obtained solid is washed again to be filtered to neutrality,
Then through 65 DEG C of vacuum drying, ball is clayed into power, spare；
（2）By step（1）In 20 parts of powder, 3 parts of laruyl alcohol sodium sulfovinate, 1 part of sodium chloride, 2 parts of sucrose fatty ester, alkalinity
3 parts of pectase, 2 parts of palmitic acid, 1 part of Antiradon, 3 parts of pyrovinic acid, 2 parts of disodium hydrogen phosphate, vacuum is carried out after being stirred
Deaeration, vacuum pressure 2*10-8Pa is then added in wet-spinning frame, by being solidified after measuring pump-metered, spinning head extrusion
It is precipitated in bath and forms fiber filaments, it is washing, dry, the coagulating bath is methyltriethoxysilane, citric acid, 1- butyl-
The mixing alcoholic solution of 3- methylimidazolium chlorides, glacial acetic acid, wherein Ethoxysilane, citric acid, 1- butyl -3- methyl chloride miaows
Azoles, glacial acetic acid molar ratio be 5:18:3:10, it handles to obtain primary dressing using stretching, sizing, weaving；
（3）By step（2）Obtained primary dressing is immersed in the hot water storgae of desizing, scouring and bleaching combined machine, sets bath raio as 1:27, first use
75 DEG C of water cleans 40-42 minutes, then water temperature is risen to 90 DEG C, adds in 2 parts of oxalic acid, cleans 30 minutes；
（4）By step（3）Obtained dressing is soaked in by propylene glycol alginate, ethylenediamine, triethylene tetramine, mannitol, nothing
Water-ethanol, water are according to mass ratio 7:3:2:2:9:In the mixed liquor of 100 compositions, damp and hot high-temperature vapor processing, high-temperature water are carried out
Steam temperature is 1000 DEG C, and it is neutral then to wash processed fabric to surface with clear water, dries to obtain through dehydration secondary
Handle dressing；
（5）By obtained after-treatment dressing through scutcher open-width, then drying machine drying and processing 20 minutes at 105 DEG C,
It gets product.
The performance test results of ventilative imbibition swelling medical dressing obtained are as shown in table 1.
Embodiment 2
（1）11 parts of cellulose gum, 6 parts of polylactic acid, 14 parts of hydroxypropyl methyl cellulose, 17 parts of hydroxyethyl cellulose are uniformly mixed
It is boiled 35 minutes with 10% sodium bicarbonate solution, mixed liquor is transferred on Rotary Evaporators afterwards then, rotary evaporation parameter is temperature
43 DEG C, pressure -0.05MPa of degree, rotary evaporation about 20min is extremely without apparent bubble and after there is white suspension particle, by suspension
It being filtered in injection Suction filtration device, 100ml ethyl alcohol is slowly added during filtering, obtained solid is washed again to be filtered to neutrality,
Then through 65 DEG C of vacuum drying, ball is clayed into power, spare；
（2）By step（1）In 22 parts of powder, 4 parts of laruyl alcohol sodium sulfovinate, 3 parts of sodium chloride, 2 parts of sucrose fatty ester, alkalinity
3 parts of pectase, 4 parts of palmitic acid, 2 parts of Antiradon, 5 parts of pyrovinic acid, 3 parts of disodium hydrogen phosphate, vacuum is carried out after being stirred
Deaeration, vacuum pressure 2*10-8Pa is then added in wet-spinning frame, by being solidified after measuring pump-metered, spinning head extrusion
It is precipitated in bath and forms fiber filaments, it is washing, dry, the coagulating bath is methyltriethoxysilane, citric acid, 1- butyl-
The mixing alcoholic solution of 3- methylimidazolium chlorides, glacial acetic acid, wherein Ethoxysilane, citric acid, 1- butyl -3- methyl chloride miaows
Azoles, glacial acetic acid molar ratio be 5:18:3:10, it handles to obtain primary dressing using stretching, sizing, weaving；
（3）By step（2）Obtained primary dressing is immersed in the hot water storgae of desizing, scouring and bleaching combined machine, sets bath raio as 1:27, first use
75 DEG C of water cleans 40-42 minutes, then water temperature is risen to 90 DEG C, adds in 2 parts of oxalic acid, cleans 30 minutes；
（4）By step（3）Obtained dressing is soaked in by propylene glycol alginate, ethylenediamine, triethylene tetramine, mannitol, nothing
Water-ethanol, water are according to mass ratio 7:3:2:2:9:In the mixed liquor of 100 compositions, damp and hot high-temperature vapor processing, high-temperature water are carried out
Steam temperature is 1000 DEG C, and it is neutral then to wash processed fabric to surface with clear water, dries to obtain through dehydration secondary
Handle dressing；
（5）By obtained after-treatment dressing through scutcher open-width, then drying machine drying and processing 20 minutes at 105 DEG C,
It gets product.
The performance test results of ventilative imbibition swelling medical dressing obtained are as shown in table 1.
Embodiment 3
（1）14 parts of cellulose gum, 8 parts of polylactic acid, 16 parts of hydroxypropyl methyl cellulose, 19 parts of hydroxyethyl cellulose are uniformly mixed
It is boiled 35 minutes with 10% sodium bicarbonate solution, mixed liquor is transferred on Rotary Evaporators afterwards then, rotary evaporation parameter is temperature
44 DEG C, pressure -0.05MPa of degree, rotary evaporation about 20min is extremely without apparent bubble and after there is white suspension particle, by suspension
It being filtered in injection Suction filtration device, 100ml ethyl alcohol is slowly added during filtering, obtained solid is washed again to be filtered to neutrality,
Then through 65 DEG C of vacuum drying, ball is clayed into power, spare；
（2）By step（1）In 24 parts of powder, 5 parts of laruyl alcohol sodium sulfovinate, 4 parts of sodium chloride, 3 parts of sucrose fatty ester, alkalinity
4 parts of pectase, 5 parts of palmitic acid, 2 parts of Antiradon, 6 parts of pyrovinic acid, 4 parts of disodium hydrogen phosphate, vacuum is carried out after being stirred
Deaeration, vacuum pressure 2*10-8Pa is then added in wet-spinning frame, by being solidified after measuring pump-metered, spinning head extrusion
It is precipitated in bath and forms fiber filaments, it is washing, dry, the coagulating bath is methyltriethoxysilane, citric acid, 1- butyl-
The mixing alcoholic solution of 3- methylimidazolium chlorides, glacial acetic acid, wherein Ethoxysilane, citric acid, 1- butyl -3- methyl chloride miaows
Azoles, glacial acetic acid molar ratio be 5:18:3:10, it handles to obtain primary dressing using stretching, sizing, weaving；
（3）By step（2）Obtained primary dressing is immersed in the hot water storgae of desizing, scouring and bleaching combined machine, sets bath raio as 1:27, first use
75 DEG C of water cleans 40-42 minutes, then water temperature is risen to 90 DEG C, adds in 2 parts of oxalic acid, cleans 30 minutes；
（4）By step（3）Obtained dressing is soaked in by propylene glycol alginate, ethylenediamine, triethylene tetramine, mannitol, nothing
Water-ethanol, water are according to mass ratio 7:3:2:2:9:In the mixed liquor of 100 compositions, damp and hot high-temperature vapor processing, high-temperature water are carried out
Steam temperature is 1000 DEG C, and it is neutral then to wash processed fabric to surface with clear water, dries to obtain through dehydration secondary
Handle dressing；
（5）By obtained after-treatment dressing through scutcher open-width, then drying machine drying and processing 20 minutes at 105 DEG C,
It gets product.
The performance test results of ventilative imbibition swelling medical dressing obtained are as shown in table 1.
Embodiment 4
（1）15 parts of cellulose gum, 9 parts of polylactic acid, 18 parts of hydroxypropyl methyl cellulose, 20 parts of hydroxyethyl cellulose are uniformly mixed
It is boiled 35 minutes with 10% sodium bicarbonate solution, mixed liquor is transferred on Rotary Evaporators afterwards then, rotary evaporation parameter is temperature
45 DEG C, pressure -0.05MPa of degree, rotary evaporation about 20min is extremely without apparent bubble and after there is white suspension particle, by suspension
It being filtered in injection Suction filtration device, 100ml ethyl alcohol is slowly added during filtering, obtained solid is washed again to be filtered to neutrality,
Then through 65 DEG C of vacuum drying, ball is clayed into power, spare；
（2）By step（1）In 25 parts of powder, 6 parts of laruyl alcohol sodium sulfovinate, 5 parts of sodium chloride, 4 parts of sucrose fatty ester, alkalinity
5 parts of pectase, 6 parts of palmitic acid, 3 parts of Antiradon, 7 parts of pyrovinic acid, 5 parts of disodium hydrogen phosphate, vacuum is carried out after being stirred
Deaeration, vacuum pressure 2*10-8Pa is then added in wet-spinning frame, by being solidified after measuring pump-metered, spinning head extrusion
It is precipitated in bath and forms fiber filaments, it is washing, dry, the coagulating bath is methyltriethoxysilane, citric acid, 1- butyl-
The mixing alcoholic solution of 3- methylimidazolium chlorides, glacial acetic acid, wherein Ethoxysilane, citric acid, 1- butyl -3- methyl chloride miaows
Azoles, glacial acetic acid molar ratio be 5:18:3:10, it handles to obtain primary dressing using stretching, sizing, weaving；
（3）By step（2）Obtained primary dressing is immersed in the hot water storgae of desizing, scouring and bleaching combined machine, sets bath raio as 1:27, first use
75 DEG C of water cleans 40-42 minutes, then water temperature is risen to 90 DEG C, adds in 2 parts of oxalic acid, cleans 30 minutes；
（4）By step（3）Obtained dressing is soaked in by propylene glycol alginate, ethylenediamine, triethylene tetramine, mannitol, nothing
Water-ethanol, water are according to mass ratio 7:3:2:2:9:In the mixed liquor of 100 compositions, damp and hot high-temperature vapor processing, high-temperature water are carried out
Steam temperature is 1000 DEG C, and it is neutral then to wash processed fabric to surface with clear water, dries to obtain through dehydration secondary
Handle dressing；
（5）By obtained after-treatment dressing through scutcher open-width, then drying machine drying and processing 20 minutes at 105 DEG C,
It gets product.
The performance test results of ventilative imbibition swelling medical dressing obtained are as shown in table 1.
Comparative example 1
（1）9 parts of cellulose gum, 4 parts of polylactic acid, 12 parts of hydroxypropyl methyl cellulose, 15 parts of hydroxyethyl cellulose are uniformly mixed
It is boiled 35 minutes with 10% sodium bicarbonate solution, mixed liquor is transferred on Rotary Evaporators afterwards then, rotary evaporation parameter is temperature
42 DEG C, pressure -0.05MPa of degree, rotary evaporation about 20min is extremely without apparent bubble and after there is white suspension particle, by suspension
It being filtered in injection Suction filtration device, 100ml ethyl alcohol is slowly added during filtering, obtained solid is washed again to be filtered to neutrality,
Then through 65 DEG C of vacuum drying, ball is clayed into power, spare；
（2）By step（1）In 20 parts of powder, 1 part of sodium chloride, 2 parts of sucrose fatty ester, 2 parts of palmitic acid, 1 part of Antiradon,
3 parts of pyrovinic acid, 2 parts of disodium hydrogen phosphate, carry out vacuum defoamation, vacuum pressure 2*10 after being stirred-8Pa is then added in wet
In method spinning-drawing machine, by being precipitated in coagulating bath after measuring pump-metered, spinning head extrusion and forming fiber filaments, washing, drying,
The coagulating bath is methyltriethoxysilane, the mixing alcoholic solution of citric acid, 1- butyl -3- methylimidazolium chlorides, glacial acetic acid,
Wherein Ethoxysilane, citric acid, 1- butyl -3- methylimidazolium chlorides, glacial acetic acid molar ratio be 5:18:3:10, using
It stretches, shape, weaving handles to obtain primary dressing；
（3）By step（2）Obtained primary dressing is immersed in the hot water storgae of desizing, scouring and bleaching combined machine, sets bath raio as 1:27, first use
75 DEG C of water cleans 40-42 minutes, then water temperature is risen to 90 DEG C, adds in 2 parts of oxalic acid, cleans 30 minutes；
（4）By step（3）Obtained dressing is soaked in by propylene glycol alginate, ethylenediamine, triethylene tetramine, mannitol, nothing
Water-ethanol, water are according to mass ratio 7:3:2:2:9:In the mixed liquor of 100 compositions, damp and hot high-temperature vapor processing, high-temperature water are carried out
Steam temperature is 1000 DEG C, and it is neutral then to wash processed fabric to surface with clear water, dries to obtain through dehydration secondary
Handle dressing；
（5）By obtained after-treatment dressing through scutcher open-width, then drying machine drying and processing 20 minutes at 105 DEG C,
It gets product.
The performance test results of ventilative imbibition swelling medical dressing obtained are as shown in table 1.
Comparative example 2
（1）15 parts of cellulose gum, 9 parts of polylactic acid, 18 parts of hydroxypropyl methyl cellulose, 20 parts of hydroxyethyl cellulose are uniformly mixed
It is boiled 35 minutes with 10% sodium bicarbonate solution, mixed liquor is transferred on Rotary Evaporators afterwards then, rotary evaporation parameter is temperature
45 DEG C, pressure -0.05MPa of degree, rotary evaporation about 20min is extremely without apparent bubble and after there is white suspension particle, by suspension
It being filtered in injection Suction filtration device, 100ml ethyl alcohol is slowly added during filtering, obtained solid is washed again to be filtered to neutrality,
Then through 65 DEG C of vacuum drying, ball is clayed into power, spare；
（2）By step（1）In 25 parts of powder, 6 parts of laruyl alcohol sodium sulfovinate, 5 parts of sodium chloride, 4 parts of sucrose fatty ester, alkalinity
5 parts of pectase, 6 parts of palmitic acid, 3 parts of Antiradon, 7 parts of pyrovinic acid, 5 parts of disodium hydrogen phosphate, vacuum is carried out after being stirred
Deaeration, vacuum pressure 2*10-8Pa is then added in wet-spinning frame, by forming fibre after measuring pump-metered, spinning head extrusion
Filament is tieed up, washing, drying handle to obtain primary dressing using stretching, sizing, weaving；
（3）By step（2）Obtained primary dressing is immersed in the hot water storgae of desizing, scouring and bleaching combined machine, sets bath raio as 1:27, first use
75 DEG C of water cleans 40-42 minutes, then water temperature is risen to 90 DEG C, adds in 2 parts of oxalic acid, cleans 30 minutes；
（4）By step（3）Obtained dressing is soaked in by propylene glycol alginate, ethylenediamine, triethylene tetramine, mannitol, nothing
Water-ethanol, water are according to mass ratio 7:3:2:2:9:In the mixed liquor of 100 compositions, damp and hot high-temperature vapor processing, high-temperature water are carried out
Steam temperature is 1000 DEG C, and it is neutral then to wash processed fabric to surface with clear water, dries to obtain through dehydration secondary
Handle dressing；
（5）By obtained after-treatment dressing through scutcher open-width, then drying machine drying and processing 20 minutes at 105 DEG C,
It gets product.
The performance test results of ventilative imbibition swelling medical dressing obtained are as shown in table 1.
The imbibition swelling medical dressing that will breathe freely made from embodiment 1-4 and comparative example 1-2 carries out gas permeability, moisture absorption respectively
This several rate, hydrostatic pressing performance tests.
Table 1
The present invention ventilative imbibition swelling medical dressing preparation method by cellulose gum, polylactic acid, hydroxypropyl methyl cellulose,
Prepared by the processing steps such as the main raw material(s)s such as hydroxyethyl cellulose are boiled by alkaline process, evaporated, filtering, washing, drying, ball milling applies
The base material of material, then by laruyl alcohol sodium sulfovinate, sodium chloride, sucrose fatty ester, alkaline pectase, palmitic acid, Antiradon,
The raw materials such as pyrovinic acid, disodium hydrogen phosphate respectively through stirring and evenly mixing, vacuum defoamation, wet spinning, metering spinneret, coagulating bath,
Stretching, sizing, weaving, rinsing, activation, damp and hot high temperature steam treatment, dehydration dry, open-width, drying and etc. be prepared
Aspiration liquid is swollen medical dressing.The ventilative imbibition swelling medical dressing being prepared, permeability is good, water imbibition is strong, imbibition
Swelling function is strong, can meet medical treatment it is medical in a variety of demands.The present invention ventilative imbibition swelling medical dressing raw material be easy to get,
It is simple for process, it is used suitable for heavy industrialization, it is highly practical.
The foregoing is merely the embodiment of the present invention, are not intended to limit the scope of the invention, every to utilize this hair
The equivalent structure or equivalent flow shift that bright description is made directly or indirectly is used in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (6)
1. a kind of preparation method of ventilative imbibition swelling medical dressing, which is characterized in that include the following steps：
（1）By 9-15 parts of cellulose gum, 4-9 parts of polylactic acid, 12-18 parts of hydroxypropyl methyl cellulose, hydroxyethyl cellulose 15-20
Part is boiled 35 minutes after mixing with 10% sodium bicarbonate solution, and then mixed liquor is transferred on Rotary Evaporators, and rotation is steamed
About 20min is sent out to without apparent bubble and after there is white suspension particle, suspension is injected in Suction filtration device and is filtered, filters process
In be slowly added 100ml ethyl alcohol, washed filtering is to neutrality again for obtained solid, then through 65 DEG C of vacuum drying, ball grinds
End, it is spare；
（2）By step（1）In 20-25 parts of powder, 3-6 parts of laruyl alcohol sodium sulfovinate, 1-5 parts of sodium chloride, sucrose fatty ester
2-4 parts, 3-5 parts of alkaline pectase, 2-6 parts of palmitic acid, 1-3 parts of Antiradon, 3-7 parts of pyrovinic acid, disodium hydrogen phosphate 2-5
Part, carry out vacuum defoamation after being stirred, then add in wet-spinning frame in, by measure pump-metered, spinning head extrude after
It is precipitated in coagulating bath and forms fiber filaments, washing, drying, the coagulating bath is methyltriethoxysilane, citric acid, 1- fourths
The mixing alcoholic solution of base -3- methylimidazolium chlorides, glacial acetic acid, wherein Ethoxysilane, citric acid, 1- butyl -3- methyl chlorides
Imidazoles, glacial acetic acid molar ratio be 5:18:3:10, it handles to obtain primary dressing using stretching, sizing, weaving；
（3）By step（2）Obtained primary dressing is immersed in the hot water storgae of desizing, scouring and bleaching combined machine, sets bath raio as 1:27, first use
75-80 DEG C of water cleans 40-42 minutes, then water temperature is risen to 90-95 DEG C, adds in 2-6 parts of activator, cleans 30-45 minutes；
（4）By step（3）Obtained dressing is soaked in by propylene glycol alginate, ethylenediamine, triethylene tetramine, mannitol, nothing
Water-ethanol, water are according to mass ratio 7:3:2:2:9:In the mixed liquor of 100 compositions, damp and hot high-temperature vapor processing is carried out, then will
It is neutral that processed fabric, which is washed with clear water to surface, dries to obtain after-treatment dressing through dehydration；
（5）By obtained after-treatment dressing through scutcher open-width, then drying machine drying and processing 20- at 105-110 DEG C
40 minutes to get finished product.
2. the preparation method of ventilative imbibition swelling medical dressing according to claim 1, which is characterized in that the step
（1）In rotary evaporation parameter for 42-45 DEG C of temperature, pressure -0.05MPa.
3. the preparation method of ventilative imbibition swelling medical dressing according to claim 1, which is characterized in that the step
（2）In vacuum pressure be 2*10-8Pa。
4. the preparation method of ventilative imbibition swelling medical dressing according to claim 1, which is characterized in that the step
（2）In drying carried out by radiating, contacting heating, temperature is 110-115 DEG C.
5. the preparation method of ventilative imbibition swelling medical dressing according to claim 1, which is characterized in that the step
（3）In activator be selected from oxalic acid, sodium carbonate, copper sulphate, one or more of sodium citrate.
6. the preparation method of ventilative imbibition swelling medical dressing according to claim 1, which is characterized in that the step
（4）In high-temperature vapor temperature be 1000-1100 DEG C.
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| CN117298321A (en) * | 2023-09-22 | 2023-12-29 | 山东融元康医疗科技有限公司 | Medical skin care dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101172164A (en) * | 2006-11-03 | 2008-05-07 | 中国科学院化学研究所 | Biopolymer nano tunica fibrosa material capable of being biological degraded and absorbed, preparing method and uses of the same |
| CN102908653A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Preparation method of antiseptic dressing for deep infection wound |
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2018
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101172164A (en) * | 2006-11-03 | 2008-05-07 | 中国科学院化学研究所 | Biopolymer nano tunica fibrosa material capable of being biological degraded and absorbed, preparing method and uses of the same |
| CN102908653A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Preparation method of antiseptic dressing for deep infection wound |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117298321A (en) * | 2023-09-22 | 2023-12-29 | 山东融元康医疗科技有限公司 | Medical skin care dressing and preparation method thereof |
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Application publication date: 20180622 |