CN106894111A - A kind of preparation method of the compound alginate dressing of soft moisture absorption - Google Patents
A kind of preparation method of the compound alginate dressing of soft moisture absorption Download PDFInfo
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- CN106894111A CN106894111A CN201710203445.3A CN201710203445A CN106894111A CN 106894111 A CN106894111 A CN 106894111A CN 201710203445 A CN201710203445 A CN 201710203445A CN 106894111 A CN106894111 A CN 106894111A
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/18—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from other substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F11/00—Chemical after-treatment of artificial filaments or the like during manufacture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention discloses a kind of preparation method of the compound alginate dressing of soft moisture absorption, carboxymethyl chitosan/sodium alginate mixed liquor is first formed be modified crosslinked with carboxymethyl chitosan of the sodium alginate extracted in brown alga, propylene glycol alginate is added to be uniformly mixed to form wet spinning stoste, with the solidification liquid that calcium chloride solution is the first coagulating bath, with zinc chloride, magnesium chloride, any one solution in copper chloride is the solidification liquid of the second gelation, carry out wet spinning technology and fiber is obtained, processed by needle punched non-woven fabrics again, cutting, packaging and sterilization process finished product.The alginate dressing that the present invention is prepared has good imbibition, moisturizing, antibacterial, hemostatic function, simultaneously because the three-dimensional effect of carboxymethyl causes to tie up the reaction force attenuation between macromolecular in dressing, so as to the pliability of enhanced fiber, so as to more conform to individual demand of the patient to dressing, have a good application prospect.
Description
Technical field
The present invention relates to medical disposable material technical field, specifically comprising a kind of preparation of the compound alginate dressing of soft moisture absorption
Method.
Background technology
Alginates（alginate）, also referred to as algin（algin）, alginic acid（alginic acid）, be one kind brown
The widely distributed anion polysaccharide of frustule wall, viscoloid is combined to form by with water.Extracted from natural brown seaweed
Alginates, be subsequently converted to mosanom or calcium alginate.The making of alginate dressing can use braiding or non-woven technology,
It is seemingly similar to cotton.When being placed in wound bed, can react to form gelatin with wound exudate, create wet
Property healing environment, bacterium " can additionally be bottled up ", reach purification wound bed effect.During dressing, gelatinous dressing can
To remove easily, residual can also be clean with normal saline flushing.
Alginates can be processed and be prepared into alginate fibre by wet spinning technology, and fiber can be further processed into yarn
Line, woven fabric, knitted fabric and non-woven fabric material.The non-weaving cloth being made up of calcium alginate fibre can be processed to Medical coating
Material, for nursing the wound bled and suppurate.Because calcium alginate fibre has unique ion-exchange performance and gel-forming property, by
The medical dressing that calcium alginate fibre is processed into has good hygroscopicity and moisture retention, and wound can be more promoted than traditional cotton gauze
The healing of mouth.But pure alginate fibre is harder crisp, strength is relatively low, shows according to another clinical practice result feedback, for oozing
The more wound of liquid, its moisture pick-up properties cannot also meet well.With the development of medical material, in the urgent need to having more
The fibrous material of high-hygroscopicity meets the market demand.
The content of the invention
It is an object of the invention to overcome above-mentioned deficiency of the prior art, there is provided a kind of compound alginates of soft moisture absorption
The preparation method of dressing, it has the function such as imbibition, insulation, analgesic, antibacterial.
To solve above-mentioned technical barrier, the technical scheme that the present invention is provided is：A kind of compound alginates of soft moisture absorption are applied
The preparation method of material, first forms carboxymethyl chitosan be modified crosslinked with carboxymethyl chitosan of the sodium alginate extracted in brown alga
Sugar/sodium alginate mixed liquor, adds propylene glycol alginate and is uniformly mixed to form wet spinning stoste, with calcium chloride solution
It is the solidification liquid of the first coagulating bath, the solidification with any one solution in zinc chloride, magnesium chloride, copper chloride as the second gelation
Liquid, carries out wet spinning technology and fiber is obtained, then by needle punched non-woven fabrics processing, cutting, packaging and sterilization process finished product.
Preferably, the sodium alginate process cross-linking modified with carboxymethyl chitosan is as follows：
（1）It is respectively configured carboxymethyl chitosan sugar aqueous solution and 1 ~ 10% sodium alginate aqueous solution that mass fraction is 1 ~ 10%；
（2）By weight it is 1 by two kinds of solution of carboxymethyl chitosan and sodium alginate：1 ~ 3 ratio is under 40 ~ 60 DEG C of hot baths
It is sufficiently mixed, is stirring evenly and then adding into the cross-linking agent aqueous solution that a certain amount of mass fraction is 0.1 ~ 1% so that entirely mixing
In liquid system the concentration of crosslinking agent be 0.5 ~ 1mmol/L, quickly stir evenly, and under same bath temperature heat 1 ~ 4 hour, fully
Reaction, obtains final product the carboxymethyl chitosan/sodium alginate mixed liquor after crosslinking.
Preferably, described step（2）Middle crosslinking agent is the mixture of glutaraldehyde and Geniposide, and its weight ratio is 1：2~5.
Preferably, the amount that the propylene glycol alginate is added is the weight hundred of carboxymethyl chitosan/sodium alginate mixed liquor
Divide the 0.5 ~ 30% of ratio, stirred under 40 ~ 60 DEG C of hot baths after addition and obtain final product wet spinning stoste.
Preferably, the wet spinning technology be by the spinning solution by measuring pump-metered, then through candle filter,
Connecting tube and enter spinning head；The stoste thread extruded from the eyelet on spinneret cap is solidified into coagulating bath, in solidification
Separated out in bath and form as-spun fibre；The solidification is at twice：The solidification liquid of solidification is the chlorination of mass fraction 2 ~ 5% for the first time
Calcium solution, setting temperature is 40 ~ 60 DEG C；The solidification liquid mass fraction for solidifying for second is 2 ~ 10% zinc chloride, magnesium chloride, chlorine
Change any one of copper, the setting temperature of the second gelation is 50 ~ 70 DEG C.
Preferably, sub-wire operation is included in the wet spinning technology.
Preferably, the sub-wire operation is sprayed and/or impregnated using sub-wire solution to fiber, described sub-wire solution
It is 50 ~ 100% glycerin solution.
Beneficial effects of the present invention are：（1）Carboxymethyl chitosan can pass through two with alginate under without organic solvent
Relatively stable structure is formed under person's electrostatic attraction effect, and the complexing that reacted in the presence of crosslinking agent forms what is more stablized
Compound, is conducive to keeping the stabilization of properties of product；（2）Simple glutaraldehyde cross-linking agent can be in alginate fibre remained on surface one
Divide glutaraldehyde, so as to carry out certain toxicity to dressing belt, toxicity problem is solved although with Geniposide, but cross-linking effect is less
It is preferable.And combine the two, a small amount of glutaraldehyde is mixed in Geniposide can not only control toxicity problem, and can be obviously improved
The effect of crosslinking；（3）Alginates process obtained blended fiber through wet spinning technology again after being crosslinked with carboxymethyl chitosan,
Because the three-dimensional effect of carboxymethyl causes the reaction force attenuation between blended fiber macromolecular, so that enhanced fiber is flexible
Property, simultaneously because contain amino in carboxymethyl chitosan, so as to enhance the antibiotic property of dressing；（4）In the preparation of blended fiber
During, the sub-wire operation of uniqueness is with the addition of, solve the problems, such as easily to be cohered between fiber and fiber, be conducive to follow-up adding
Work；（5）Due to adding water miscible nonionic propylene glycol alginate in blended fiber, in blended fiber and wound fluid
During contact, substantial amounts of moisture can be sucked fiber by the propylene glycol alginate in one side fiber, so as to increase fiber and by fibre
The moisture pick-up properties of the medical dressing that dimension is processed into；On the other hand, alginate is steady during propylene glycol alginate can activate blended fiber
Fixed structure, makes it easier to that ion exchange occurs with the sodium ion in wound fluid, therefore improve the gel-forming property of fiber
With moisture absorption, performance of keeping humidity.
Specific embodiment
The present invention is described further with reference to embodiment；Following examples are only used for clearly illustrating this hair
Bright object, technical solution and advantage, can not be limited the scope of the invention with this.
Embodiment 1：
（1）Configuration quality fraction is 1% carboxymethyl chitosan sugar aqueous solution, is designated as A liquid；The sodium alginate aqueous solution of configuration 5%, note
It is B liquid；Configuration quality fraction is that 0.5%, solute is that glutaraldehyde and Geniposide are 1 according to weight ratio：The aqueous solution of 2 mixing, is designated as
Crosslinking agent C liquid.
（2）By weight it is 1 by A liquid and B liquid：3 ratio is sufficiently mixed under 50 DEG C of hot baths, is stirring evenly and then adding into
A certain amount of C liquid so that the concentration of crosslinking agent is 0.6mmol/L in whole mixture system, is quickly stirred evenly, and in same water
Heated 1 hour under bath temperature, fully reaction, obtain final product the carboxymethyl chitosan/sodium alginate mixing D liquid after crosslinking.
（3）It is the 30% of D liquid propylene glycol alginate to add weight, is thoroughly mixed under 50 DEG C of hot baths, obtains final product spinning
Stoste E liquid.
（4）Spinning：Then spinning solution enters spinning head by measuring pump-metered through candle filter, connecting tube；From spray
The stoste thread extruded in eyelet on silk cap is solidified into coagulating bath, is separated out in coagulating bath and is formed as-spun fibre；
The solidification is at twice：The solidification liquid of solidification is the calcium chloride solution of mass fraction 5% for the first time, and setting temperature is 40 DEG C；Second
The solidification liquid of secondary solidification be 10% zinc chloride, magnesium chloride, copper chloride any one, the setting temperature of the second gelation is 60
℃。
（5）, through sub-wire pond sub-wire after washing, the sub-wire operation is using 50% glycerin solution to fiber for as-spun fibre
Sprayed and/or impregnated.
（6）The operations such as the processing of blended fiber needle punched non-woven fabrics, cutting, packaging, sterilizing through sub-wire are obtained described softness
The compound alginate dressing of moisture absorption.
Embodiment 2：
（1）Configuration quality fraction is 10% carboxymethyl chitosan sugar aqueous solution, is designated as A liquid；The sodium alginate aqueous solution of configuration 10%,
It is designated as B liquid；Configuration quality fraction is 0.1% and weight ratio is 1：The mixed liquor of 4 glutaraldehydes and Geniposide, is designated as crosslinking agent C liquid.
（2）By weight it is 1 by A liquid and B liquid：2 ratio is sufficiently mixed under 40 DEG C of hot baths, is stirring evenly and then adding into
A certain amount of C liquid so that the concentration of crosslinking agent is 0.5mmol/L in whole mixture system, is quickly stirred evenly, and in same water
Heated 2 hours under bath temperature, fully reaction, obtain final product the carboxymethyl chitosan/sodium alginate mixing D liquid after crosslinking.
（3）It is the 20% of D liquid propylene glycol alginate to add weight, is thoroughly mixed under 40 DEG C of hot baths, obtains final product spinning
Silk stock solution E liquid.
（4）Spinning：Then spinning solution enters spinning head by measuring pump-metered through candle filter, connecting tube；From spray
The stoste thread extruded in eyelet on silk cap is solidified into coagulating bath, is separated out in coagulating bath and is formed as-spun fibre；
The solidification is at twice：The solidification liquid of solidification is the calcium chloride solution of mass fraction 2% for the first time, and setting temperature is 55 DEG C；Second
The solidification liquid of secondary solidification be 6% zinc chloride, magnesium chloride, copper chloride any one, the setting temperature of the second gelation is 70
℃。
（5）, through sub-wire pond sub-wire after washing, the sub-wire operation is using 70% glycerin solution to fiber for as-spun fibre
Sprayed and/or impregnated.
（6）The operations such as the processing of blended fiber needle punched non-woven fabrics, cutting, packaging, sterilizing through sub-wire are obtained described softness
The compound alginate dressing of moisture absorption.
Embodiment 3：
（1）Configuration quality fraction is 5% carboxymethyl chitosan sugar aqueous solution, is designated as A liquid；The sodium alginate aqueous solution of configuration 6%, note
It is B liquid；Configuration quality fraction is 0.6% and weight ratio is 1：3 glutaraldehyde and the mixed liquor of Geniposide, are designated as crosslinking agent C liquid.
（2）By weight it is 2 by A liquid and B liquid：3 ratio is sufficiently mixed under 60 DEG C of hot baths, is stirring evenly and then adding into
A certain amount of C liquid so that the concentration of crosslinking agent is 1mmol/L in whole mixture system, is quickly stirred evenly, and in same water-bath
At a temperature of heat 3 hours, fully reaction, obtain final product crosslinking after carboxymethyl chitosan/sodium alginate mixing D liquid.
（3）It is the 5% of D liquid propylene glycol alginate to add weight, is thoroughly mixed under 60 DEG C of hot baths, obtains final product spinning
Stoste E liquid.
（4）Spinning：Then spinning solution enters spinning head by measuring pump-metered through candle filter, connecting tube；From spray
The stoste thread extruded in eyelet on silk cap is solidified into coagulating bath, is separated out in coagulating bath and is formed as-spun fibre；
The solidification is at twice：The solidification liquid of solidification is the calcium chloride solution of mass fraction 3% for the first time, and setting temperature is 60 DEG C；Second
The solidification liquid of secondary solidification be 8% zinc chloride, magnesium chloride, copper chloride any one, the setting temperature of the second gelation is 65
℃。
（5）, through sub-wire pond sub-wire after washing, the sub-wire operation is using 90% glycerin solution to fiber for as-spun fibre
Sprayed and/or impregnated.
（6）The operations such as the processing of blended fiber needle punched non-woven fabrics, cutting, packaging, sterilizing through sub-wire are obtained described softness
The compound alginate dressing of moisture absorption.
Embodiment 4：
（1）Configuration quality fraction is 6% carboxymethyl chitosan sugar aqueous solution, is designated as A liquid；The sodium alginate aqueous solution of configuration 1%, note
It is B liquid；Configuration quality fraction is 1% and weight ratio is 1：5 glutaraldehyde and the mixed liquor of Geniposide, are designated as crosslinking agent C liquid.
（2）By weight it is 1 by A liquid and B liquid：1 ratio is sufficiently mixed under 55 DEG C of hot baths, is stirring evenly and then adding into
A certain amount of C liquid so that the concentration of crosslinking agent is 0.8mmol/L in whole mixture system, is quickly stirred evenly, and in same water
Heated 4 hours under bath temperature, fully reaction, obtain final product the carboxymethyl chitosan/sodium alginate mixing D liquid after crosslinking.
（3）It is the 0.5% of D liquid propylene glycol alginate to add weight, is thoroughly mixed under 55 DEG C of hot baths, obtains final product spinning
Silk stock solution E liquid.
（4）Spinning：Then spinning solution enters spinning head by measuring pump-metered through candle filter, connecting tube；From spray
The stoste thread extruded in eyelet on silk cap is solidified into coagulating bath, is separated out in coagulating bath and is formed as-spun fibre；
The solidification is at twice：The solidification liquid of solidification is the calcium chloride solution of mass fraction 4% for the first time, and setting temperature is 50 DEG C；Second
The solidification liquid of secondary solidification be 2% zinc chloride, magnesium chloride, copper chloride any one, the setting temperature of the second gelation is 50
℃。
（5）, through sub-wire pond sub-wire after washing, the sub-wire operation is using 100% glycerin solution to fibre for as-spun fibre
Dimension is sprayed and/or impregnated.
（6）The operations such as the processing of blended fiber needle punched non-woven fabrics, cutting, packaging, sterilizing through sub-wire are obtained described softness
The compound alginate dressing of moisture absorption.
Embodiment 5：Absorbency is tested
Dressing of the present invention is tested the absorbency of water and physiological saline.Certain mass is weighed in 60 DEG C of freeze-day with constant temperature to constant-quality
NACF W1, it is put into 100ml distilled water or 100ml physiological saline (the homemade 0.9%NaCl aqueous solution) immersion 1h
Afterwards, in putting into centrifuge tube, the bottom of centrifuge tube is filled with some filter paper, to accommodate the liquid that centrifugation is dished out, then will be from
Heart pipe is centrifuged 20 minutes under 1500r/min, liquid of the removal absorption between fiber and fiber.The fiber after centrifugation is taken out to claim
Its quality is W2.Fiber presses (W to the absorptivity of water and salt solution2-W1)/W1Ratio is calculated.The size of absorbency such as following table institute
Show：
Absorbent properties of the dressing of table 1 to distilled water
Absorbent properties of the dressing of table 2 to physiological saline
Knowable to the data in upper table, suction of the preparation-obtained alginates combine dressing of the invention to distilled water and physiological saline
Yield has significant raising.
Embodiment 6：Mechanics Performance Testing
Alginate dressing obtained by the embodiment of the present invention is cut into dumbbell shape standard specimen, in room temperature, the environment of relative humidity 65%
Middle damping 48h is with up to constant.With reference to GB/T 1040-92《Plastic tensile method for testing performance》, with CMT6104 type microcomputer controls
Electronic universal tester (newly thinking carefully measurement technology Co., Ltd in Shenzhen) processed determines the tensile strength of dressing under normality, rate of extension
50mm/min, each sample is surveyed 5 times, is averaged, and compared with mechanical performance data under the normality of common alginate dressing
Compared with as a result as shown in the table：
The mechanical property contrast of the dressing of table 3
Knowable to the data in upper table, compared with common alginates, it draws preparation-obtained alginates combine dressing of the invention
Stretch Strength Changes less, but elongation at break has and is obviously improved, therefore the pliability of dressing has and is obviously improved.
Claims (7)
1. a kind of preparation method of the compound alginate dressing of soft moisture absorption, it is characterised in that the first marine alga to be extracted in brown alga
Be modified crosslinked with carboxymethyl chitosan of sour sodium forms carboxymethyl chitosan/sodium alginate mixed liquor, adds alginate propylene glycol
Ester is uniformly mixed to form wet spinning stoste, with the solidification liquid that calcium chloride solution is the first coagulating bath, with zinc chloride, chlorination
Any one solution in magnesium, copper chloride is the solidification liquid of the second gelation, carries out wet spinning technology and fiber is obtained, then pass through
Needle punched non-woven fabrics processing, cutting, packaging and sterilization process finished product.
2. a kind of preparation method of the compound alginate dressing of soft moisture absorption according to claim 1, it is characterised in that institute
State the sodium alginate process cross-linking modified with carboxymethyl chitosan as follows：
（1）It is respectively configured carboxymethyl chitosan sugar aqueous solution and 1 ~ 10% sodium alginate aqueous solution that mass fraction is 1 ~ 10%；
（2）By weight it is 1 by two kinds of solution of carboxymethyl chitosan and sodium alginate：1 ~ 3 ratio is under 40 ~ 60 DEG C of hot baths
It is sufficiently mixed, is stirring evenly and then adding into the cross-linking agent aqueous solution that a certain amount of mass fraction is 0.1 ~ 1% so that entirely mixing
In liquid system the concentration of crosslinking agent be 0.5 ~ 1mmol/L, quickly stir evenly, and under same bath temperature heat 1 ~ 4 hour, fully
Reaction, obtains final product the carboxymethyl chitosan/sodium alginate mixed liquor after crosslinking.
3. a kind of preparation method of the compound alginate dressing of soft moisture absorption according to claim 2, it is characterised in that described
The step of（2）Middle crosslinking agent is the mixture of glutaraldehyde and Geniposide, and its weight ratio is 1：2~5.
4. a kind of preparation method of the compound alginate dressing of soft moisture absorption according to claim 1, it is characterised in that described
The amount that propylene glycol alginate is added is the 0.5 ~ 30% of the percentage by weight of carboxymethyl chitosan/sodium alginate mixed liquor, after addition
Stirred under 40 ~ 60 DEG C of hot baths and obtain final product wet spinning stoste.
5. a kind of preparation method of the compound alginate dressing of soft moisture absorption according to claim 1, it is characterised in that described
Wet spinning technology is, by measuring pump-metered, then to enter spinning head through candle filter, connecting tube by the spinning solution；
The stoste thread extruded from the eyelet on spinneret cap is solidified into coagulating bath, is separated out in coagulating bath and is formed nascent fibre
Dimension；The solidification is at twice：For the first time solidification solidification liquid for mass fraction 2 ~ 5% calcium chloride solution, setting temperature be 40 ~
60℃；The solidification liquid mass fraction of second solidification for 2 ~ 10% zinc chloride, magnesium chloride, copper chloride any one, second coagulates
Gu the setting temperature of bath is 50 ~ 70 DEG C.
6. a kind of preparation method of the compound alginate dressing of soft moisture absorption according to claim 1, it is characterised in that carry out
After fiber obtained in the wet spinning technology, sub-wire operation has also been carried out.
7. a kind of preparation method of the compound alginate dressing of soft moisture absorption according to claim 8, it is characterised in that described
Sub-wire operation is sprayed and/or impregnated using sub-wire solution to fiber, and described sub-wire solution is 50 ~ 100% glycerine water
Solution.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875434A (en) * | 2017-12-18 | 2018-04-06 | 广东泰宝医疗科技股份有限公司 | A kind of new alginate dressing that prevents adhesion |
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| CN108221081A (en) * | 2017-12-13 | 2018-06-29 | 青岛海赛尔新材料科技有限公司 | High intensity carboxymethyl cellulose/sodium alginate blended fiber and preparation method thereof |
| CN108221081B (en) * | 2017-12-13 | 2020-05-26 | 青岛海赛尔新材料科技有限公司 | High-strength carboxymethyl cellulose/sodium alginate blend fiber and preparation method thereof |
| CN107875434A (en) * | 2017-12-18 | 2018-04-06 | 广东泰宝医疗科技股份有限公司 | A kind of new alginate dressing that prevents adhesion |
| CN108977931A (en) * | 2018-08-10 | 2018-12-11 | 嘉兴学院 | A kind of composite antibacterial fibre and preparation method thereof |
| CN109550072A (en) * | 2018-10-18 | 2019-04-02 | 青岛即发集团股份有限公司 | The alginate chitosan composite fiber and its preparation method and application of imbibition swelling |
| EP3786323A1 (en) * | 2019-09-02 | 2021-03-03 | Sinotech Academy Of Textile (Qingdao) Co., Ltd. | Algae modified pp spunbond non-woven fabric |
| CN112941667A (en) * | 2021-02-05 | 2021-06-11 | 大连工业大学 | Alginate fiber and preparation method thereof |
| CN114588307A (en) * | 2022-04-08 | 2022-06-07 | 山东万容生物科技有限公司 | Alginate dressing and preparation method thereof |
| CN114588307B (en) * | 2022-04-08 | 2022-12-23 | 山东万容生物科技有限公司 | Alginate dressing and preparation method thereof |
| CN114959946A (en) * | 2022-05-30 | 2022-08-30 | 泰州市榕兴医疗用品股份有限公司 | Gel type durable antibacterial calcium alginate fiber and preparation method thereof |
| CN115054720A (en) * | 2022-07-25 | 2022-09-16 | 东华大学 | Anti-adhesion medical dressing and preparation method thereof |
| CN115054720B (en) * | 2022-07-25 | 2023-06-06 | 东华大学 | Anti-adhesion medical dressing and preparation method thereof |
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