CN107115554A - A kind of efficient hemostasis is dispelled the compound dressing and preparation method thereof of pain - Google Patents
A kind of efficient hemostasis is dispelled the compound dressing and preparation method thereof of pain Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
The present invention relates to medical supplies technical field, disclose a kind of efficient hemostasis and dispel the compound dressing and preparation method thereof of pain.Described compound dressing is prepared by modified oxidized regenerated cellulose sodium/alginate blended fiber with far infrared functional fibre through needle punched non-woven fabrics processing technology.The invention provides one kind can significantly improve alginates it is hemostatic and analgesia property, while improve alginates hygrometric state mechanical strength and assign its certain bacteriostasis property efficient hemostasis Eradicates pains compound dressing.
Description
Technical field
The present invention relates to medical supplies technical field, and in particular to a kind of efficient hemostasis is dispelled the compound dressing and its system of pain
Preparation Method.
Background technology
Hemostasis is the common approach of human body treatment of wounds, knife wound, scuffing and the wound at any position of human body almost without
One is exceptionally related to bleeding and hemostasis, and hemostatic technique develops into modern surgery condition by past simple apparatus haemostatic measures
Under numerous and complicated technical system.And wound is in addition to oozing of blood, oedema and pain be clinically in surface of a wound nursing process most
Common complication, edema wound can cause pain to aggravate, wound healing is delayed, the surface of a wound leaves the complication such as skin is superfluous.Therefore, open
Send out a class material and both possessed efficient hemostasia effect, and detumescence can be promoted, mitigate patient pain, to Wound healing and raising patient's life
Bioplasm measurer is significant.
Alginic acid（alginic acid）, be a kind of anion polysaccharide widely distributed in brown alga cell membrane, by with water
Combine to form viscoloid.Alginic acid is the polysaccharide being made up of mannuronic acid and guluronic acid, has been used as Dressing substrate
Material decades.As dressing matrix, alginic acid has highly biocompatible characteristic, can absorb substantial amounts of wound fluid shape
Into gel, the healing environment of one " moistening " is provided for wound healing, wound surface is protected, wound infection rate is reduced, promotes wound
Mouth healing, reduces the discomfort of patient during change dressings.These superior functions of alginic acid are its answering in terms of medical dressing
With bringing wide prospect.
However, pure alginic acid based material to wound without analgesic activity, and exist wet strength and mechanical integrity compared with
Low, compliance is poor and the problem of limited anthemorrhagic performance.It is the common method for solving these problems that polymer, which is blended or is combined,.
In the prior art, it is existing a large amount of on the compound side to improve functional dressing performance of alginates and other biological functional material
Method, mainly includes chitosan, collagen, gelatin, polyvinyl alcohol, pectin, cellulose fibre, fibroin albumen, hyaluronic acid
Etc. being blended or the composite modified performance to improve alginic acid based material.But the above blending or composite modified material
It there are problems that, such as the use of collagen and gelatin has immunity risk；Although chitosan can significantly improve material
The antibiotic property of material, but mechanical strength, anthemorrhagic performance improve limited；Polyvinyl alcohol can improve the mechanical strength of material, but right
It is hemostatic, do not significantly improve effect.
The content of the invention
Undesirable the invention aims to solve existing alginate material haemostatic effect, structural intergrity, machinery are strong
Degree and the relatively low technical problem of stability there is provided one kind can significantly improve alginates it is hemostatic and analgesia property, while improve algae
The compound dressing of the efficient hemostasis Eradicates pains of its certain bacteriostasis property of hydrochlorate hygrometric state mechanical strength and imparting.There is provided a kind of high simultaneously
The preparation method of the compound dressing of effect hemostasis Eradicates pains.
To achieve these goals, the technical scheme that provides of the present invention is：
A kind of efficient hemostasis is dispelled the compound dressing of pain, by modified oxidized regenerated cellulose sodium/alginate blended fiber with it is remote
Infrared functional fibre is prepared through needle punched non-woven fabrics processing technology.
Further, described modified oxidized regenerated cellulose sodium/alginate blended fiber is passed through by regenerated cellulose
Just oxidation, modified oxidized obtained modified oxidized regenerated cellulose and sodium alginate are prepared by wet spinning technology.
Further, the first oxidation step of described regenerated cellulose is：With sodium metaperiodate oxygen occurs for regenerated cellulose
Change reaction, then reacted with glycol cleaning solution, you can obtain the regenerated cellulose of just oxidation.
Further, described modified oxidized step is：Oxygen is occurred into for the regenerated cellulose just aoxidized and silver ammino solution
Change reduction reaction, you can obtain modified oxidized regenerated cellulose.
A kind of efficient hemostasis dispel pain compound dressing preparation method, its specific preparation process is as follows：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in the sodium metaperiodate aqueous solution, the pH value of solution is adjusted,
Excessive IO is removed in stirring, the glycol cleaning solution for being then placed in 0.05 ~ 0.1mol/L4 -, then cleaned with high purity water, it is freeze-dried
The regenerated cellulose just aoxidized can be obtained；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In silver ammino solution, adjuvant is added, 40 ~ 60 DEG C are heated up to, until bubble-free is produced, after being rinsed with absolute ethyl alcohol, then
With high purity water by product cleaning to neutrality, finally 24 ~ 48h is dried in 30 ~ 45 DEG C of vacuum drying chambers, you can obtain modified oxidized regeneration
Cellulose；
（3）The preparation of compound dressing：Modified oxidized regenerated cellulose and sodium alginate powder are configured to blend solution, 30
Stirring at ~ 50 DEG C is until well mixed, filtering, deaeration, obtain modified oxidized regenerated cellulose/sodium alginate co-blended spinning former
Liquid；By spinning solution by entering spinning head after spinning pump, filter, stoste thread is extruded from spinneret orifice, stoste thread enters
Nascent blended fiber is formed in coagulating bath, then after drawing-off, washing, sub-wire, drying, rolling step, obtains modified oxidized regeneration
Nothing is made through needle punched non-woven fabrics processing technology with far infrared functional fibre in sodium cellulosate/alginate blended fiber, blended fiber
Cloth coiled material is spun, then compound dressing is made through cutting, packaging, sterilizing.
It is preferred that, described step（1）The mass percent of meso-periodic acid sodium water solution is 1 ~ 5%, described pH value for 2 ~
3, lucifuge persistently stirs 1 ~ 3h at 30 ~ 40 DEG C, and glycol cleaning solution is ethylene glycol, 1,3-PD or polyethylene glycol.
It is preferred that, described step（2）In go oil processing go fluid to be formulated by following components by weight percent：Sodium hydroxide
100 ~ 200 parts of 5 ~ 15 parts, 30 ~ 60 parts of sodium acetate, 30 ~ 60 parts of sodium carbonate and distilled water；The activating solution of activation process is by weight
Number meter, is dissolved in after 10 ~ 20 parts of water respectively by 0.2 ~ 2 part of silver nitrate, 0.1 ~ 1 part of EDTA, and mixing carries out reaction generation precipitation, then drips
Ammonification water is formulated to disappearance is precipitated.
It is preferred that, described step（2）In just oxidation regenerated cellulose and silver ammino solution in solute mol ratio be 1：4
~5。
It is preferred that, described step（2）Middle adjuvant is formulated by following components by weight percent：2 ~ 6 parts of tartaric acid, concentration are
95% 60 ~ 100 parts of 5 ~ 15 parts of ethanol, 5 ~ 10 parts of butanedioic acid, 0.002 part of thiocarbamide, 0.1 ~ 2 part of EDTA and distilled water, and auxiliary
Agent mixed liquor weight is the 10 ~ 20% of silver ammino solution.
It is preferred that, described step（3）In modified oxidized regenerated cellulose and sodium alginate powder mass ratio be 1 ~ 6：
9；The mass ratio of far infrared functional fibre and blended fiber is 1 ~ 3：7.
A kind of compound dressing of efficient hemostasis Eradicates pains of the present invention, by sodium metaperiodate on regenerated cellulose C2 and C3 positions
Secondary hydroxyl carried out the preliminary oxidation of selectivity, then further aoxidized by silver ammino solution so as to introducing dicarboxyl, a side
Face, assigns the oxidized regenerated cellulose preferable hydrophily, and the hydrophily makes the oxidized regenerated cellulose sodium be sent out with alginate
Raw molecular level is combined（Cross-linking process except participating in alginic acid, moreover it is possible to alginic acid strand formation semi-interpenetrating polymer network
Structure）, the structural intergrity, mechanical strength and stability of compound dressing are improved, common alginates non-woven fabrics is overcome and applies
Expect low, the yielding shortcoming of insufficient strength, mechanical integrity under hygrometric state；On the other hand, the silver with redox property is utilized
Mirror reaction, and adjuvant is introduced, its regenerated cellulose surface is realized chemical deposition, by the deposition of silver of reduction to regenerated cellulose
Surface, so as to assign dressing certain bacteria resistance function.Meanwhile, in the processing preparation process of non-woven fabrics, mix far-infrared functional
Fiber, makes material have anakmetomeres, improves cell permeability, and then improves wound oxygen content, improves microcirculation and skin matter
Element, reaches the effect of swelling and pain relieving.
Beneficial effects of the present invention are：
（1）The oxidized regenerated cellulose that modified crosslinking is obtained due to containing double carboxyl structures, making its hydrophily significantly improve,
Therefore when being contacted with the bleeding surface of a wound, meet blood and expand and the moisture in blood can be absorbed rapidly, make pachyemia, viscosity increases
Greatly, velocity of blood flow slows down；Viscosity very strong colloid can be formed after dissolving, and then can well block and oppress capillary.
（2）In the modified oxidized regenerated cellulose sodium of the present invention/alginate hemostasis composite, contained by alginate
Ca2+Release, can promote the formation of thrombokinase, accelerate hemostasis process.Therefore, modified oxidized regenerated cellulose sodium/
The double-hemostasis function that alginate hemostasis composite has oxidized regenerated cellulose sodium and alginate is acted on, and makes bleeding stopping period big
It is big to shorten, reach the effect of quick-acting haemostatic powder, overcome that common alginates adhesive-bonded fabric dressing hemostatic mechanism is single, anthemorrhagic speed slowly with
And the limited shortcoming of haemostatic effect.
（3）Far infrared functional fibre is introduced in alginate composite, improves microcirculation and skin quality, cell is improved
Permeability and skin oxygen content, possess preferable swelling and pain relieving effect.
（4）It is certain due to having after alginate imbibition itself into colloidality so that dressing is difficult and wound after imbibition
Adhesion, is effectively protected wound, prevents secondary injury.
（5）Regenerated cellulose it is modified oxidized during, using the generation of redox reaction, realize elemental silver
Chemical deposition, the surface of regenerated fiber forms the silver of a part of good bonding strength, so as to impart the certain antibacterial work(of dressing
Energy.
（6）The preparation process of the composite of the present invention without special installation, reaction condition gentle, technical maturity, be adapted to
In the large-scale production of modification regeneration sodium cellulosate/alginates hemostasis composite.
Specific embodiment
The present invention is described further with reference to embodiment；Following examples are only used for clearly illustrating this hair
Bright object, technical solution and advantage, can not be limited the scope of the invention with this.
Embodiment 1：
A kind of efficient hemostasis is dispelled the compound dressing of pain, by modified oxidized regenerated cellulose sodium/alginate blended fiber with it is remote
Infrared functional fibre is prepared through needle punched non-woven fabrics processing technology.Described modified oxidized regenerated cellulose sodium/alginate
Blended fiber is to be passed through by regenerated cellulose through just oxidation, modified oxidized obtained modified oxidized regenerated cellulose and sodium alginate
What wet spinning technology was prepared.
A kind of efficient hemostasis dispel pain compound dressing preparation method, its preparation method comprises the following steps that：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in mass percent in the 1% sodium metaperiodate aqueous solution, to adjust
The pH value of solution is saved to 3, lucifuge persistently stirs 2h at 35 DEG C, is then placed in 0.05mol/L ethylene glycol cleaning solution, finally
Cleaning, freezing, drying can obtain the regenerated cellulose just aoxidized；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In the silver ammino solution of 5 times of molal quantitys, adjuvant is added, 40 DEG C are heated up to, until bubble-free is produced, by product cleaning into
Property, the most vacuum drying chamber after 45 DEG C dries 24h, you can obtain modified oxidized regenerated cellulose；
（3）The preparation of compound dressing：By modified oxidized regenerated cellulose and sodium alginate powder according to mass ratio 1：9 are made into altogether
Miscible fluid, the stirring at 40 DEG C are until well mixed, filtering, deaeration, obtain modified oxidized regenerated cellulose/sodium alginate blending
Spinning solution, modified oxidized regenerated cellulose sodium/alginate blended fiber is made by wet spinning technology, blended fiber with
Far infrared functional fibre is 1 in mass ratio：7 ratio through needle punched non-woven fabrics processing technology be made non-woven fabric coiled material, then through cutting,
Compound dressing is made in packaging, sterilizing.
Above-mentioned step（2）In go fluid to be formulated by following components by weight percent：5 parts of sodium hydroxide, 40 parts of sodium acetate, carbon
150 parts of 60 parts of sour sodium and distilled water.Activating solution fraction meter by weight, 15 parts of water are dissolved in by 2 parts of silver nitrates, 0.8 part of EDTA respectively
Afterwards, mixing is carried out reacting generation precipitation, then dropwise addition ammoniacal liquor is formulated to disappearance is precipitated into the solution of generation precipitation.Adjuvant
It is formulated by following components by weight percent：4 parts of tartaric acid, concentration for 95% 15 parts of ethanol, 5 parts of butanedioic acid, 0.002 part of thiocarbamide,
EDTA0.5 parts and 70 parts of distilled water, adjuvant mixed liquor weight are the 15% of silver ammino solution.
Embodiment 2：
A kind of efficient hemostasis is dispelled the compound dressing of pain, by modified oxidized regenerated cellulose sodium/alginate blended fiber with it is remote
Infrared functional fibre is prepared through needle punched non-woven fabrics processing technology.Described modified oxidized regenerated cellulose sodium/alginate
Blended fiber is to be passed through by regenerated cellulose through just oxidation, modified oxidized obtained modified oxidized regenerated cellulose and sodium alginate
What wet spinning technology was prepared.
A kind of efficient hemostasis dispel pain compound dressing preparation method, its preparation method comprises the following steps that：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in mass percent in the 4% sodium metaperiodate aqueous solution, to adjust
The pH value of solution is saved to 2, lucifuge persistently stirs 3h at 30 DEG C, is then placed in 0.08mol/L 1,3-PD cleaning solution,
Finally clean, freeze, drying can obtain the regenerated cellulose just aoxidized；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In the silver ammino solution of 4 times of molal quantitys, adjuvant is added, 60 DEG C are heated up to, until bubble-free is produced, by product cleaning into
Property, the most vacuum drying chamber after 30 DEG C dries 48h, you can obtain modified oxidized regenerated cellulose；
（3）The preparation of compound dressing：By modified oxidized regenerated cellulose and sodium alginate powder according to mass ratio 2：9 are made into altogether
Miscible fluid, the stirring at 30 DEG C are until well mixed, filtering, deaeration, obtain modified oxidized regenerated cellulose/sodium alginate blending
Spinning solution, modified oxidized regenerated cellulose sodium/alginate blended fiber is made by wet spinning technology, blended fiber with
Far infrared functional fibre is 3 in mass ratio：7 ratio through needle punched non-woven fabrics processing technology be made non-woven fabric coiled material, then through cutting,
Compound dressing is made in packaging, sterilizing.
Above-mentioned step（2）In go fluid to be formulated by following components by weight percent：15 parts of sodium hydroxide, 30 parts of sodium acetate,
100 parts of 50 parts of sodium carbonate and distilled water.Activating solution fraction meter by weight, 18 parts are dissolved in by 1 part of silver nitrate, 0.1 part of EDTA respectively
After water, mixing is carried out reacting generation precipitation, then dropwise addition ammoniacal liquor is formulated to disappearance is precipitated into the solution of generation precipitation.Auxiliary
Agent is formulated by following components by weight percent：10 parts of ethanol, 8 parts of butanedioic acid, thiocarbamide 0.002 that 2 parts of tartaric acid, concentration are 95%
Part, EDTA0.1 parts and 80 parts of distilled water, adjuvant mixed liquor weight are the 10% of silver ammino solution.
Embodiment 3：
A kind of efficient hemostasis is dispelled the compound dressing of pain, by modified oxidized regenerated cellulose sodium/alginate blended fiber with it is remote
Infrared functional fibre is prepared through needle punched non-woven fabrics processing technology.Described modified oxidized regenerated cellulose sodium/alginate
Blended fiber is to be passed through by regenerated cellulose through just oxidation, modified oxidized obtained modified oxidized regenerated cellulose and sodium alginate
What wet spinning technology was prepared.
A kind of efficient hemostasis dispel pain compound dressing preparation method, its preparation method comprises the following steps that：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in mass percent in the 3% sodium metaperiodate aqueous solution, to adjust
The pH value of solution is saved to 2.5, lucifuge persistently stirs 1h at 40 DEG C, is then placed in 0.1mol/L polyethylene glycol cleaning solution,
Finally clean, freeze, drying can obtain the regenerated cellulose just aoxidized；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In the silver ammino solution of 5 times of molal quantitys, adjuvant is added, 50 DEG C are heated up to, until bubble-free is produced, by product cleaning into
Property, the most vacuum drying chamber after 40 DEG C dries 36h, you can obtain modified oxidized regenerated cellulose；
（3）The preparation of compound dressing：By modified oxidized regenerated cellulose and sodium alginate powder according to mass ratio 6：9 are made into altogether
Miscible fluid, the stirring at 45 DEG C are until well mixed, filtering, deaeration, obtain modified oxidized regenerated cellulose/sodium alginate blending
Spinning solution, modified oxidized regenerated cellulose sodium/alginate blended fiber is made by wet spinning technology, blended fiber with
Far infrared functional fibre is 2 in mass ratio：7 ratio through needle punched non-woven fabrics processing technology be made non-woven fabric coiled material, then through cutting,
Compound dressing is made in packaging, sterilizing.
Above-mentioned step（2）In go fluid to be formulated by following components by weight percent：10 parts of sodium hydroxide, 50 parts of sodium acetate,
200 parts of 30 parts of sodium carbonate and distilled water.Activating solution fraction meter by weight, 20 are dissolved in by 0.2 part of silver nitrate, 0.5 part of EDTA respectively
After part water, mixing react generating and precipitated, then the extremely precipitation disappearance of dropwise addition ammoniacal liquor is formulated into the solution of generation precipitation.It is auxiliary
Auxiliary agent is formulated by following components by weight percent：5 parts of ethanol, 6 parts of butanedioic acid, thiocarbamide 0.002 that 6 parts of tartaric acid, concentration are 95%
Part, EDTA2 parts and 60 parts of distilled water, adjuvant mixed liquor weight are the 18% of silver ammino solution.
Embodiment 4：
A kind of efficient hemostasis is dispelled the compound dressing of pain, by modified oxidized regenerated cellulose sodium/alginate blended fiber with it is remote
Infrared functional fibre is prepared through needle punched non-woven fabrics processing technology.Described modified oxidized regenerated cellulose sodium/alginate
Blended fiber is to be passed through by regenerated cellulose through just oxidation, modified oxidized obtained modified oxidized regenerated cellulose and sodium alginate
What wet spinning technology was prepared.
A kind of efficient hemostasis dispel pain compound dressing preparation method, its preparation method comprises the following steps that：
（1）The first oxidation of regenerated cellulose：Regenerated cellulose is soaked in mass percent in the 5% sodium metaperiodate aqueous solution, to adjust
The pH value of solution is saved to 3, lucifuge persistently stirs 2.5h at 37 DEG C, is then placed in 0.06mol/L 1,3-PD cleaning solution
In, finally clean, freeze, drying can obtain the regenerated cellulose just aoxidized；
（2）The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, immersion
In the silver ammino solution of 4 times of molal quantitys, adjuvant is added, 45 DEG C are heated up to, until bubble-free is produced, by product cleaning into
Property, the most vacuum drying chamber after 35 DEG C dries 30h, you can obtain modified oxidized regenerated cellulose；
（3）The preparation of compound dressing：By modified oxidized regenerated cellulose and sodium alginate powder according to mass ratio 5：9 are made into altogether
Miscible fluid, the stirring at 50 DEG C are until well mixed, filtering, deaeration, obtain modified oxidized regenerated cellulose/sodium alginate blending
Spinning solution, modified oxidized regenerated cellulose sodium/alginate blended fiber is made by wet spinning technology, blended fiber with
Far infrared functional fibre is 3 in mass ratio：7 ratio through needle punched non-woven fabrics processing technology be made non-woven fabric coiled material, then through cutting,
Compound dressing is made in packaging, sterilizing.
Above-mentioned step（2）In go fluid to be formulated by following components by weight percent：8 parts of sodium hydroxide, 60 parts of sodium acetate, carbon
180 parts of 40 parts of sour sodium and distilled water.Activating solution fraction meter by weight, 10 parts of water are dissolved in by 1.5 parts of silver nitrates, 1 part of EDTA respectively
Afterwards, mixing is carried out reacting generation precipitation, then dropwise addition ammoniacal liquor is formulated to disappearance is precipitated into the solution of generation precipitation.Adjuvant
It is formulated by following components by weight percent：3 parts of tartaric acid, concentration for 95% 8 parts of ethanol, 10 parts of butanedioic acid, 0.002 part of thiocarbamide,
EDTA1 parts and 100 parts of distilled water, adjuvant mixed liquor weight are the 20% of silver ammino solution.
Experimental example 5：Hemostasis trial
Choose body weight 3.0-5.0kg new zealand rabbits and be divided into six groups, every group 6, contrast four embodiment products of the present invention and common
The anthemorrhagic performance of alginates bleeding-stopping dressing.Test dressing is cut into some pieces of 2.0cm × 2.0cm sizes, weighs, sterilize, standby.
During experiment, slowly injected after Nembutal sodium solution anesthetized animal by 40mg/kg dose intravenous, its central arteria auricularis region is standby
Skin, sterilization, skin is cut along arteria auricularis direction, and blunt separation goes out arteria auricularis, vein and nerve, then dynamic with scalpel transversely cutting
Arteries and veins, is pasted on wound surface with 1 layer of test material immediately after blood is gushed out and is applied 3N pressure, record using pull and push dynamometer
Bleeding stopping period and blood loss, and the weight of hemostatic material or dressing used in weighing respectively before and after experiment.As a result it is as shown in table 1：
The thrombotest of the compound dressing of table 1
Upper table experiment results proved, combine dressing 100s at least faster than common tourniquet bandage bleeding stopping period prepared by the present invention, because
The haemostatic effect of this product of the invention is significantly improved, and this is primarily due to play alginates and modified oxidized regeneration
The double-hemostasis function effect of cellulose.
Experimental example 6：Swelling and pain relieving therapeutic effect
By the obtained compound dressing of the processing of the embodiment of the present invention 1 ~ 4 with common alginates functional dressing simultaneously for clinically
With the nursing for treating for the surface of a wound that swells and ache.
（1）Criterion of therapeutical effect
Formulated according to State Administration of Traditional Chinese Medicine《Chinese Illnesses Diagnoses criterion of therapeutical effect》：1. cure：The symptom such as swell and ache disappears, wound
Face is healed, and main physico-chemical examination index is normal.2. it is effective：Partial symptoms are eliminated or cardinal symptom is eliminated, and the surface of a wound heals substantially,
Physico-chemical examination index is normal.3. it is effective：Cardinal symptom is substantially eliminated, and is swollen and ache and is largely decorporated, and the surface of a wound starts healing, main
Physico-chemical examination index is wanted to make moderate progress.4. it is invalid：Swell and ache without being clearly better, the surface of a wound does not have healing.
（2）As a result
In this clinical practice, in totally 196, man 103, female 93,20~70 years old age.Seen using above-mentioned two classes product
Examine.The surface of a wound and sterilized using preceding cleaning, take out product, deposited core is directed at wound center.After every dressing is used 24~48 hours
Change, be within 1 week a course for the treatment of, continuously 2 courses for the treatment of of treatment.Without using other related methods for the treatment of and medicine of influence result during treatment
Thing.
As shown in Table 2, in 196 patients, 102 of healing, effective 40, effective 33, invalid 21.
The therapeutic effect of 2 three kinds of different symptoms of table
As can be seen that the combine dressing product that is formed of the present invention from above-mentioned table, although its total effective rate for being nursed to the surface of a wound with
Existing product correlation is not fairly obvious, but in terms of wound improvement（In healing, effective, effective differentiation）Still exist larger
Difference, the obvious nursing to the surface of a wound of product of the invention is more excellent, and it has effect of more significant swelling and pain relieving.
Experimental example 7：Hygrometric state mechanical strength
Hygrometric state mechanical property test：The compound dressing of alginates using the gained of embodiment 1 ~ 4 as test sample, common alginates without
Cloth dressing is spun as control sample, each dumbbell shape standard specimen will be cut into, the damping 48h in room temperature, the environment of relative humidity 65%
With up to constant.With reference to GB/T 1040-92《Plastic tensile method for testing performance》, with CMT6104 types microcomputer controlled electronic ten thousand
Energy testing machine (newly thinking carefully measurement technology Co., Ltd in Shenzhen) determines the tensile strength of dressing under normality, rate of extension 50mm/
Min, each sample is surveyed 5 times, is averaged, and be compared with mechanical performance data under the normality of common alginate dressing；Separately
Above two alginate dressing is immersed in simulation sepage（Weigh 8.3gNaCl and 0.367gCaCl22H2O is diluted to 1L
It is standby afterwards）, it is divided into 4 groups by the difference of soak time and is tested：4h, 8h, 12h and 24h, the result measured are as shown in table 3.From
As can be seen that the product of patent of the present invention significantly improves mechanical property of the dressing under hygrometric state in table.
The normality of table 3 under each time point hygrometric state with not improving the medical bar tensile strength of alginates（Unit：MPa）
As can be seen that the more common alginates of product of the present invention, especially its mechanical strength, hygrometric state from the result of the test of table 3
Mechanical strength is significantly improved.From the foregoing, it can be seen that because introduce double carboxyls in modification regeneration cellulose, it can be with
The cross-linking process of alginic acid, moreover it is possible to alginic acid strand formation semi-interpenetrating polymer network structure, applied so as to improve and be combined
Structural intergrity, mechanical strength and the stability of material, overcoming general insufficient strength can lack under alginates adhesive-bonded fabric dressing hygrometric state
Point.The present invention further demonstrates the correctness of the viewpoint by experiment.
Claims (10)
- The compound dressing of pain 1. a kind of efficient hemostasis is dispelled, it is characterised in that described compound dressing is by modified oxidized regeneration Sodium cellulosate/alginate blended fiber is prepared with far infrared functional fibre through needle punched non-woven fabrics processing technology.
- 2. a kind of compound dressing of efficient hemostasis Eradicates pains according to claim 1, it is characterised in that described modification oxygen Change regenerated cellulose sodium/alginate blended fiber be by regenerated cellulose through just oxidation, it is modified oxidized obtain it is modified oxidized What regenerated cellulose was prepared with sodium alginate by wet spinning technology.
- 3. the compound dressing of a kind of efficient hemostasis Eradicates pains according to claim 2, it is characterised in that described regeneration is fine Tieing up plain first oxidation step is：With sodium metaperiodate oxidation reaction occurs for regenerated cellulose, then is reacted with glycol cleaning solution, i.e., The regenerated cellulose just aoxidized can be obtained.
- 4. a kind of compound dressing of efficient hemostasis Eradicates pains according to claim 3, it is characterised in that described modification oxygen Changing step is：Redox reaction is occurred into for the regenerated cellulose just aoxidized and silver ammino solution, you can obtain modified oxidized regeneration fine Dimension element.
- The preparation method of the compound dressing of pain, its feature 5. a kind of efficient hemostasis as described in claim any one of 1-4 is dispelled It is, described preparation method is comprised the following steps that：The first oxidation of regenerated cellulose：Regenerated cellulose is dipped into the sodium metaperiodate aqueous solution, the pH value of solution is adjusted, stirs Mix, be then placed in 0.05 ~ 0.1mol/L glycol cleaning solution, then cleaned with high purity water, be freeze-dried to obtain what is just aoxidized Regenerated cellulose；The preparation of modified oxidized regenerated cellulose：The regenerated cellulose just aoxidized is deoiled, cleaned after activation process, silver is soaked in In ammonia solution, add adjuvant, be heated up to 40 ~ 60 DEG C, until bubble-free is produced, by product cleaning to neutrality, finally 30 ~ 45 DEG C of vacuum drying chambers dry 24 ~ 48h, you can obtain modified oxidized regenerated cellulose；The preparation of compound dressing：Modified oxidized regenerated cellulose and sodium alginate powder are configured to blend solution, 30 ~ 50 Stirring at DEG C is until well mixed, and filtering, deaeration obtains modified oxidized regenerated cellulose/sodium alginate co-blended spinning stoste, leads to Cross wet spinning technology and modified oxidized regenerated cellulose sodium/alginate blended fiber, blended fiber and far-infrared functional is made Non-woven fabric coiled material is made through needle punched non-woven fabrics processing technology in fiber, then compound dressing is made through cutting, packaging, sterilizing.
- 6. a kind of preparation method of the compound dressing of efficient hemostasis Eradicates pains according to claim 5, it is characterised in that institute The step of stating（1）The mass percent of meso-periodic acid sodium water solution is 1 ~ 5%, and described pH value is 2 ~ 3, the lucifuge at 30 ~ 40 DEG C 1 ~ 3h is persistently stirred, glycol cleaning solution is ethylene glycol, 1,3-PD or polyethylene glycol.
- 7. a kind of preparation method of the compound dressing of efficient hemostasis Eradicates pains according to claim 5, it is characterised in that institute The step of stating（2）In go oil processing go fluid to be formulated by following components by weight percent：5 ~ 15 parts of sodium hydroxide, sodium acetate 30 ~ 100 ~ 200 parts of 60 parts, 30 ~ 60 parts of sodium carbonate and distilled water；The activating solution of activation process is counted by weight, by 0.2 ~ 2 part of nitre Sour silver, 0.1 ~ 1 part of EDTA are distinguished after molten 10 ~ 20 parts of water, mix progress reaction generation precipitation, then ammoniacal liquor extremely precipitation disappearance is added dropwise and match somebody with somebody System is formed.
- 8. a kind of preparation method of the compound dressing of efficient hemostasis Eradicates pains according to claim 5, it is characterised in that institute The step of stating（2）In just oxidation regenerated cellulose and silver ammino solution in solute mol ratio be 1：4~5.
- 9. a kind of preparation method of the compound dressing of efficient hemostasis Eradicates pains according to claim 5, it is characterised in that institute The step of stating（2）Middle adjuvant is formulated by following components by weight percent：2 ~ 6 parts of tartaric acid, concentration for 95% 5 ~ 15 parts of ethanol, 60 ~ 100 parts of 5 ~ 10 parts of butanedioic acid, 0.002 part of thiocarbamide, 0.1 ~ 2 part of EDTA and distilled water, and adjuvant mixed liquor weight is silver The 10 ~ 20% of ammonia solution.
- 10. a kind of preparation method of the compound dressing of efficient hemostasis Eradicates pains according to claim 5, it is characterised in that Described step（3）In modified oxidized regenerated cellulose and sodium alginate powder mass ratio be 1 ~ 6：9；Far infrared functional fibre Mass ratio with blended fiber is 1 ~ 3：7.
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| CN113975455A (en) * | 2021-10-28 | 2022-01-28 | 赛克赛斯生物科技股份有限公司 | Absorbable styptic powder and preparation method and application thereof |
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