CN109589318A - A kind of composite membrane for the nursing of topical type staphylococcal scalded skin syndrome - Google Patents
A kind of composite membrane for the nursing of topical type staphylococcal scalded skin syndrome Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
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- A61P31/02—Local antiseptics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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Abstract
The present invention provides a kind of composite membranes for the nursing of topical type staphylococcal scalded skin syndrome, nursing suitable for infant patient's cutaneous lesion, the compound film raw material is fucoidin, sodium alginate, Phyla nodiflora nano-cellulose, the preparation method comprises the following steps: extracting polysaccharide from bladder-wrack；Then fucoidin and sodium alginate are configured to mixed solution；Phyla nodiflora herb is passed through into ultrasonic microwave simex cellulose and is prepared into nano-cellulose；Phyla nodiflora nano-cellulose is blended with fucoidin and mixed solution of sodium alginate again, is formed a film by electrostatic spinning technique preparation to obtain the final product.The composite membrane has effects that detoxify scattered silt, anti-inflammatory, acceleration of wound healing, has certain adsorption capacity to wound exudates, can be used for the nursing of infant's topical type staphylococcal scalded skin syndrome cutaneous lesion.
Description
Technical field
The present invention relates to medical instruments fields, and in particular to one kind is comprehensive for topical type staphylococcic scald sample skin
The composite membrane of nursing is levied, which is made using fucoidin, sodium alginate and Phyla nodiflora nano-cellulose by raw material, safety
It is non-stimulated, have effects that detoxify scattered silt, anti-inflammatory, acceleration of wound healing and there is certain adsorption capacity to wound exudates,
It can be used for the nursing of infant's topical type staphylococcal scalded skin syndrome cutaneous lesion.
Background technique
Staphylococcal scalded skin syndrome, which is that one kind is serious, strips off type impetigo, and onset is hurried, easily in erythema
On the basis of there is slackness bleb, then epidermis sheet strips off, and the surface of a wound is rendered as cerise erosion surface and such as scalds sample.This disease is mostly
Number betides infant, can clinically be divided into three types, be respectively: whole body type, frustration form and topical type.Topical type staphylococcic
Scalded skin syndrome can generate impetigo bullosa, flaccid vesicle wall, and blister is fragile.Clinic generallys use the deposited side of dressing humidification
Method nurses infant cutaneous lesion, however infant's skin is tender, and phylactic power defensive power is low, and soak may produce infant's skin
Raw stimulation, soak are also possible to induce infant flu, then cause to generate heat, causing infant, sb.'s illness took a turn for the worse.
Bladder-wrack main product France, polysaccharide is one of main component of bladder-wrack.Fucoidin not only has the work of moisturizing
With, and there are a variety of physiological actions such as antiviral, antimicrobial, anticoagulation.Fucoidin can also be by accelerating 2 β of surface α
Expression of 1 gene on fibroblast promotes the contraction of collagen gel, so that acceleration of wound heals.
Chinese medicine Phyla nodiflora is Verenaceae Phyla nodiflora book plant Phyla nodiflora Phyla nodiflora (L.) Greene
[Lippia nodiflora (L.) Rich.], with all herbal medicine, effect is clearing heat and detoxicating, scattered and swollen, and external application can treat ulcer
The diseases such as serious case of furuncle, shingles zoster, chronic eczema.
Sodium alginate is nontoxic food, can and its it is mild under conditions of quickly form gel, as stabilizer and
Thickener is widely used in food and medicine industry.
As previously mentioned, to staphylococcal scalded skin syndrome infant cutaneous lesion in such a way that dressing humidification applies
Carrying out nursing has certain risk.And fucoidin energy is antiviral, antimicrobial, anticoagulant and promotes blood circulation, accelerates wound
It recovers from injury and closes；Chinese medicine Phyla nodiflora also can be clearing heat and detoxicating, external curing dermatitis and eczema, the diseases such as ulcer serious case of furuncle, shingles zoster.If with black angle
Polysaccharides, Chinese medicine Phyla nodiflora are raw material, and sodium alginate is added, and researching and developing one kind has removing toxic substances scattered silt, anti-inflammatory, acceleration of wound healing function
Effect and the composite membrane for having certain adsorption capacity to wound exudates then can be used for infant's topical type staphylococcic scald sample
The nursing of skin syndrome cutaneous lesion helps infant early recovery.
Summary of the invention
In order to solve foregoing problems, the present invention provides a kind of for topical type staphylococcal scalded skin syndrome shield
The composite membrane of reason is used for the nursing of infant patient's cutaneous lesion, and the composite membrane is with fucoidin, sodium alginate and Phyla nodiflora
Nano-cellulose is made of raw material, safe and non-stimulating, has effects that detoxify scattered silt, anti-inflammatory, acceleration of wound healing, can be used for
The nursing of infant's topical type staphylococcal scalded skin syndrome cutaneous lesion.
A kind of composite membrane for the nursing of topical type staphylococcal scalded skin syndrome, by the following technical programs
It realizes:
(1) fucoidin is prepared；
(2) fucoidin and mixed solution of sodium alginate are prepared；
(3) Phyla nodiflora cellulose is prepared；
(4) Phyla nodiflora nano-cellulose is prepared
(5) Phyla nodiflora nano-cellulose is blended with fucoidin and mixed solution of sodium alginate and prepares composite membrane to get one
Composite membrane of the kind for the nursing of topical type staphylococcal scalded skin syndrome.
Further, the fucoidin is the preparation method comprises the following steps: take bladder-wrack that deionization is added according to solid-to-liquid ratio 1: 5
Water dialyses 3 days remove salinity at room temperature, crushes after drying, and crosses 100 meshes, and adding concentration according to solid-to-liquid ratio 1: 2 is 70%-
80% ethyl alcohol soaked overnight degreasing, filters and recycle ethyl alcohol, residue is according to solid-to-liquid ratio 1: (10-20) plus deionized water ultrasound mention
It takes.It is concentrated after extracting solution is filtered, addition dehydrated alcohol to alcohol content 80%, stands overnight precipitation precipitating, precipitating is collected by centrifugation
And with washes of absolute alcohol, then it is dried for standby for 45 DEG C.
Further, in fucoidin preparation process: the ultrasonic extraction time is 50-70min, power 300-400W；
It is 3000r/min, time 20min that revolving speed in precipitation process, which is collected by centrifugation,.
Further, the preparation method of the fucoidin and mixed solution of sodium alginate are as follows: weigh sodium alginate
It is dissolved in deionized water, the sodium alginate soln that concentration is 2wt% is configured to, then according to 100mL: the ratio of (5-10) g
Fucoidin is added to stir evenly.
Further, the Phyla nodiflora cellulose the preparation method comprises the following steps: take the dry herb of Phyla nodiflora, smash it through 100
Mesh is added 2%NaOH solution, is placed in ultrasonic-microwave association response system and reacts 1h, then filter out NaOH solution,
Substrate is washed to neutrality and dried；2% liquor natrii hypochloritis is added according to solid-to-liquid ratio 1: 10, then with 5% hydrochloric acid tune pH value
It is during which persistently stirred to 2-3 in 80 DEG C of water bath with thermostatic control 2h.Then it filters, residue washing to neutrality is dried for standby.
Further, in the preparation process of the Phyla nodiflora cellulose: Phyla nodiflora medicinal material and 2%NaOH solution solid-liquid
Than being 1: (10-15)；In ultrasound-microwave combined reaction system treatment process, ultrasound and microwave power are 300W.
Further, the Phyla nodiflora nano-cellulose the preparation method comprises the following steps: Phyla nodiflora cellulose is weighed, by solid-to-liquid ratio
1: (8-15) ratio is added deionized water and obtains pulpous state Phyla nodiflora in the ball mill with the revolving speed ball milling 3h of 1000r/min and receive
Rice cellulose colloidal solutions are then centrifuged for taking supernatant, be freeze-dried spare.
Further, Phyla nodiflora nano-cellulose be blended with fucoidin and mixed solution of sodium alginate be prepared into it is compound
The method of film are as follows: according to 100mL in fucoidin and mixed solution of sodium alginate: Phyla nodiflora is added in the ratio of (5-10) g
Nano-cellulose simultaneously persistently stirs 1h under the conditions of 40 DEG C, is formed a film after being cooled to 25 DEG C by electrostatic spinning technique preparation up to one
Composite membrane of the kind for the nursing of topical type staphylococcal scalded skin syndrome.
Further, the electrospinning conditions are as follows: spinning flow is 2-6mL/h；Spinning voltage is 8-12Kv；Spinning
Receiving distance is 10cm.
Beneficial effects of the present invention:
A kind of composite membrane for the nursing of topical type staphylococcal scalded skin syndrome of the present invention, the composite membrane
It is made using fucoidin, sodium alginate and Phyla nodiflora nano-cellulose by raw material, it is safe and non-stimulating, there is removing toxic substances scattered silt, resist
The effect of scorching, acceleration of wound heals, and have certain adsorption capacity to wound exudates, it can be used for infant's topical type Portugal
The nursing of the coccus scalded skin syndrome cutaneous lesion of grape.
Detailed description of the invention
Fig. 1 is the production technological process of composite membrane of the present invention.
Specific embodiment:
Complete detailed description is carried out to the present invention below in conjunction with specific embodiment, described embodiment is only this hair
A part in bright whole embodiments, but scope of protection of the present invention is not limited thereto, is equal to technology of the invention
Replacement or change are not innovated sufficiently, should be covered by the scope of protection of the present invention.
Embodiment 1
The present invention provides it is a kind of for topical type staphylococcal scalded skin syndrome nursing composite membrane and its
Preparation method, the composite membrane are prepared by fucoidin, sodium alginate, Phyla nodiflora nano-cellulose, including are prepared as follows
Step:
(1) fucoidin is prepared；
(2) fucoidin and mixed solution of sodium alginate are prepared；
(3) Phyla nodiflora cellulose is prepared；
(4) Phyla nodiflora nano-cellulose is prepared
(5) Phyla nodiflora nano-cellulose is blended with fucoidin and mixed solution of sodium alginate and prepares composite membrane to get one
Composite membrane of the kind for the nursing of topical type staphylococcal scalded skin syndrome.
The fucoidin is prepared by the following method to obtain: taking bladder-wrack that deionization is added according to solid-to-liquid ratio 1: 5
Water dialyses 3 days remove salinity at room temperature, crushes, sieve with 100 mesh sieve after drying, and adds 70% ethyl alcohol according to solid-to-liquid ratio 1: 2 and impregnated
Night degreasing, filters and recycles ethyl alcohol, and residue is according to solid-to-liquid ratio 1: 10 plus deionized water ultrasonic extraction 70min, ultrasonic power
300W.It is concentrated after extracting solution is filtered, addition dehydrated alcohol to alcohol content 80%, stands overnight precipitation precipitating, 3000rpm/
Min is centrifuged 20min, collects precipitating and with washes of absolute alcohol, is then dried for standby for 45 DEG C.
The preparation method of the fucoidin and mixed solution of sodium alginate are as follows: weigh sodium alginate 2g and be dissolved in
In 98g deionized water, 5g fucoidin is then added and stirs evenly.
The Phyla nodiflora cellulose the preparation method comprises the following steps: take the dry herb of Phyla nodiflora, smash it through 100 meshes, according to
2%NaOH solution is added in solid-to-liquid ratio 1: 10, is placed in the microwave combined reaction system of ultrasonic wave-and reacts 1h, ultrasonic wave and microwave function
Rate is set as 300W, then filters out NaOH solution, and substrate is washed to neutrality and dried；2% is added according to solid-to-liquid ratio 1: 10
Liquor natrii hypochloritis, then with 5% hydrochloric acid tune pH value to 2, in 80 DEG C of water bath with thermostatic control 2h, during which persistently stir.Then it filters, it will
Residue washing is dried for standby to neutrality.
The Phyla nodiflora nano-cellulose the preparation method comprises the following steps: weigh Phyla nodiflora cellulose, add in 1: 8 ratio of solid-to-liquid ratio
Enter deionized water, in the ball mill with the revolving speed ball milling 3h of 1000r/min, it is molten to obtain pulpous state Phyla nodiflora nano-cellulose colloid
Liquid is then centrifuged for taking supernatant, be freeze-dried spare.
Phyla nodiflora nano-cellulose is blended to the side for being prepared into composite membrane with fucoidin and mixed solution of sodium alginate
Method are as follows: take fucoidin and mixed solution of sodium alginate 100mL, 5g Phyla nodiflora nano-cellulose is added and under the conditions of 40 DEG C
1h is persistently stirred, passing through electrostatic spinning technique after being cooled to 25 DEG C according to spinning flow is 2mL/h, spinning voltage 8Kv, spinning
The condition that distance is 10cm is received, preparation, which forms a film, nurses up to a kind of for topical type staphylococcal scalded skin syndrome
Composite membrane.
Embodiment 2
The present invention provides it is a kind of for topical type staphylococcal scalded skin syndrome nursing composite membrane and its
Preparation method, the composite membrane are prepared by fucoidin, sodium alginate, Phyla nodiflora nano-cellulose, including are prepared as follows
Step:
(1) fucoidin is prepared；
(2) fucoidin and mixed solution of sodium alginate are prepared；
(3) Phyla nodiflora cellulose is prepared；
(4) Phyla nodiflora nano-cellulose is prepared
(5) Phyla nodiflora nano-cellulose is blended with fucoidin and mixed solution of sodium alginate and prepares composite membrane to get one
Composite membrane of the kind for the nursing of topical type staphylococcal scalded skin syndrome.
The fucoidin is prepared by the following method to obtain: taking bladder-wrack that deionization is added according to solid-to-liquid ratio 1: 5
Water dialyses 3 days remove salinity at room temperature, crushes, sieve with 100 mesh sieve after drying, and adds 75% ethyl alcohol according to solid-to-liquid ratio 1: 2 and impregnated
Night degreasing, filters and recycles ethyl alcohol, and residue is according to solid-to-liquid ratio 1: 15 plus deionized water ultrasonic extraction 60min, ultrasonic power
300W.It is concentrated after extracting solution is filtered, addition dehydrated alcohol to alcohol content 80%, stands overnight precipitation precipitating, 3000rpm/
Min is centrifuged 20min, collects precipitating and with washes of absolute alcohol, is then dried for standby for 45 DEG C.
The preparation method of the fucoidin and mixed solution of sodium alginate are as follows: weigh sodium alginate 2g and be dissolved in
In 98g deionized water, 7g fucoidin is then added and stirs evenly.
The Phyla nodiflora cellulose the preparation method comprises the following steps: take the dry herb of Phyla nodiflora, smash it through 100 meshes, according to
2%NaOH solution is added in solid-to-liquid ratio 1: 12, is placed in the microwave combined reaction system of ultrasonic wave-and reacts 1h, ultrasonic wave and microwave function
Rate is set as 300W, then filters out NaOH solution, and substrate is washed to neutrality and dried；2% is added according to solid-to-liquid ratio 1: 10
Liquor natrii hypochloritis, then with 5% hydrochloric acid tune pH value to 3, in 80 DEG C of water bath with thermostatic control 2h, during which persistently stir.Then it filters, it will
Residue washing is dried for standby to neutrality.
The Phyla nodiflora nano-cellulose the preparation method comprises the following steps: Phyla nodiflora cellulose is weighed, in 1: 10 ratio of solid-to-liquid ratio
Deionized water is added, it is molten to obtain pulpous state Phyla nodiflora nano-cellulose colloid in the ball mill with the revolving speed ball milling 3h of 1000r/min
Liquid is then centrifuged for taking supernatant, be freeze-dried spare.
Phyla nodiflora nano-cellulose is blended to the side for being prepared into composite membrane with fucoidin and mixed solution of sodium alginate
Method are as follows: take fucoidin and mixed solution of sodium alginate 100mL, 8g Phyla nodiflora nano-cellulose is added and under the conditions of 40 DEG C
1h is persistently stirred, passing through electrostatic spinning technique after being cooled to 25 DEG C according to spinning flow is 4mL/h, spinning voltage 10Kv, is spun
Silk receives the condition that distance is 10cm, and preparation, which forms a film, to be protected up to a kind of for topical type staphylococcal scalded skin syndrome
The composite membrane of reason.
Embodiment 3
The present invention provides it is a kind of for topical type staphylococcal scalded skin syndrome nursing composite membrane and its
Preparation method, the composite membrane are prepared by fucoidin, sodium alginate, Phyla nodiflora nano-cellulose, including are prepared as follows
Step:
(1) fucoidin is prepared；
(2) fucoidin and mixed solution of sodium alginate are prepared；
(3) Phyla nodiflora cellulose is prepared；
(4) Phyla nodiflora nano-cellulose is prepared
(5) Phyla nodiflora nano-cellulose is blended with fucoidin and mixed solution of sodium alginate and prepares composite membrane to get one
Composite membrane of the kind for the nursing of topical type staphylococcal scalded skin syndrome.
The fucoidin is prepared by the following method to obtain: taking bladder-wrack that deionization is added according to solid-to-liquid ratio 1: 5
Water dialyses 3 days remove salinity at room temperature, crushes, sieve with 100 mesh sieve after drying, and adds 80% ethyl alcohol according to solid-to-liquid ratio 1: 2 and impregnated
Night degreasing, filters and recycles ethyl alcohol, and residue is according to solid-to-liquid ratio 1: 20 plus deionized water ultrasonic extraction 50min, ultrasonic power
400W.It is concentrated after extracting solution is filtered, addition dehydrated alcohol to alcohol content 80%, stands overnight precipitation precipitating, 3000rpm/
Min is centrifuged 20min, collects precipitating and with washes of absolute alcohol, is then dried for standby for 45 DEG C.
The preparation method of the fucoidin and mixed solution of sodium alginate are as follows: weigh sodium alginate 3g and be dissolved in
In 147g deionized water, 15g fucoidin is then added and stirs evenly.
The Phyla nodiflora cellulose the preparation method comprises the following steps: take the dry herb of Phyla nodiflora, smash it through 100 meshes, according to
2%NaOH solution is added in solid-to-liquid ratio 1: 15, is placed in the microwave combined reaction system of ultrasonic wave-and reacts 1h, ultrasonic wave and microwave function
Rate is set as 300W, then filters out NaOH solution, and substrate is washed to neutrality and dried；2% is added according to solid-to-liquid ratio 1: 10
Liquor natrii hypochloritis, then with 5% hydrochloric acid tune pH value to 3, in 80 DEG C of water bath with thermostatic control 2h, during which persistently stir.Then it filters, it will
Residue washing is dried for standby to neutrality.
The Phyla nodiflora nano-cellulose the preparation method comprises the following steps: Phyla nodiflora cellulose is weighed, in 1: 15 ratio of solid-to-liquid ratio
Deionized water is added, it is molten to obtain pulpous state Phyla nodiflora nano-cellulose colloid in the ball mill with the revolving speed ball milling 3h of 1000r/min
Liquid is then centrifuged for taking supernatant, be freeze-dried spare.
Phyla nodiflora nano-cellulose is blended to the side for being prepared into composite membrane with fucoidin and mixed solution of sodium alginate
Method are as follows: take fucoidin and mixed solution of sodium alginate 100mL, 10g Phyla nodiflora nano-cellulose is added and in 40 DEG C of conditions
Persistently stir 1h down, after being cooled to 25 DEG C by electrostatic spinning technique according to spinning flow be 6mL/h, spinning voltage 12Kv,
Spinning receives the condition that distance is 10cm, and preparation forms a film up to a kind of for topical type staphylococcal scalded skin syndrome
The composite membrane of nursing.
Claims (9)
1. a kind of composite membrane for the nursing of topical type staphylococcal scalded skin syndrome, which is characterized in that prepare material
Material includes fucoidin, sodium alginate, Phyla nodiflora nano-cellulose, which is prepared by following preparation method:
(1) fucoidin is prepared；
(2) fucoidin and mixed solution of sodium alginate are prepared；
(3) Phyla nodiflora cellulose is prepared；
(4) Phyla nodiflora nano-cellulose is prepared
(5) Phyla nodiflora nano-cellulose is blended with fucoidin and mixed solution of sodium alginate and prepares composite membrane to get one
Composite membrane of the kind for the nursing of topical type staphylococcal scalded skin syndrome.
2. composite membrane according to claim 1, which is characterized in that the fucoidin is the preparation method comprises the following steps: take black angle
Deionized water is added according to solid-to-liquid ratio 1: 5 in algae, dialyses 3 days remove salinity at room temperature, crush, sieve with 100 mesh sieve after drying, according to solid
It is the soaked overnight degreasing of 70%-80% ethyl alcohol that liquor ratio 1: 2, which adds concentration, filters and recycle ethyl alcohol, residue is according to solid-to-liquid ratio 1:
(10-20) plus deionized water ultrasonic extraction.It is concentrated after extracting solution is filtered, adds dehydrated alcohol to alcohol content 80%, stood
Precipitating is precipitated in night, precipitating is collected by centrifugation and with washes of absolute alcohol, is then dried for standby for 45 DEG C.
3. compound membrane preparation method according to claim 2, the ultrasonic extraction time is 50-70min, power 300-
400W；It is 3000r/min, time 20min that revolving speed in precipitation process, which is collected by centrifugation,.
4. compound membrane preparation method according to claim 1, which is characterized in that the fucoidin and sodium alginate
The preparation method of mixed solution are as follows: weigh sodium alginate and be dissolved in deionized water, be configured to the sodium alginate that concentration is 2wt%
Solution, then according to 100mL: the ratio of (5-10) g is added fucoidin and stirs evenly.
5. compound membrane preparation method according to claim 1, which is characterized in that Phyla nodiflora cellulose the preparation method comprises the following steps:
The dry herb of Phyla nodiflora is taken, 100 meshes is smashed it through, 2%NaOH solution is added, is placed in ultrasonic-microwave association response system
Middle reaction 1h, then filters out NaOH solution, and substrate is washed to neutrality and dried；2% chlorine is added according to solid-to-liquid ratio 1: 10
Acid sodium solution, then during which persistently stirred to 2-3 in 80 DEG C of water bath with thermostatic control 2h with 5% hydrochloric acid tune pH value.Then it filters, will filter
Wash heat is washed to neutrality, is dried for standby.
6. compound membrane preparation method according to claim 5, which is characterized in that Phyla nodiflora medicinal material and 2%NaOH solution are solid
Liquor ratio is 1: (10-15)；In ultrasound-microwave combined reaction system treatment process, ultrasound and microwave power are 300W.
7. compound membrane preparation method according to claim 1, which is characterized in that the preparation method of Phyla nodiflora nano-cellulose
Are as follows: Phyla nodiflora cellulose is weighed, in solid-to-liquid ratio 1: deionized water is added in (8-15) ratio, in the ball mill with 1000r/min's
Revolving speed ball milling 3h obtains pulpous state Phyla nodiflora nano-cellulose colloidal solution, is then centrifuged for taking supernatant, be freeze-dried spare.
8. compound membrane preparation method according to claim 1, which is characterized in that by Phyla nodiflora nano-cellulose and bladder-wrack
The method for being prepared into composite membrane is blended in polysaccharide and mixed solution of sodium alginate are as follows: in fucoidin and mixed solution of sodium alginate
According to 100mL: the ratio of (5-10) g is added Phyla nodiflora nano-cellulose and simultaneously persistently stirs 1h under the conditions of 40 DEG C, is cooled to
It is formed a film after 25 DEG C by electrostatic spinning technique preparation and is protected up to a kind of for topical type staphylococcal scalded skin syndrome
The composite membrane of reason.
9. compound membrane preparation method according to claim 8, which is characterized in that the electrospinning conditions are as follows: spinning
Flow is 2-6mL/h；Spinning voltage is 8-12Kv；It is 10cm that spinning, which receives distance,.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811568690.5A CN109589318A (en) | 2018-12-12 | 2018-12-12 | A kind of composite membrane for the nursing of topical type staphylococcal scalded skin syndrome |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811568690.5A CN109589318A (en) | 2018-12-12 | 2018-12-12 | A kind of composite membrane for the nursing of topical type staphylococcal scalded skin syndrome |
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| CN109589318A true CN109589318A (en) | 2019-04-09 |
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| CN201811568690.5A Pending CN109589318A (en) | 2018-12-12 | 2018-12-12 | A kind of composite membrane for the nursing of topical type staphylococcal scalded skin syndrome |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110184680A (en) * | 2019-05-20 | 2019-08-30 | 青岛大学 | A kind of fucoidin micro Nano material and preparation method thereof |
| WO2021161252A1 (en) * | 2020-02-13 | 2021-08-19 | Bakel S.R.L. | Method of electrospinning natural polymers |
| WO2021161250A1 (en) * | 2020-02-13 | 2021-08-19 | Bakel S.R.L. | Natural composition based on polymers to be electrospun, and method to prepare the same |
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| CN105251045A (en) * | 2015-10-20 | 2016-01-20 | 青岛明月生物医用材料有限公司 | Fucoidin-containing biomedical hydrogel and preparation method thereof |
| CN106521706A (en) * | 2016-11-15 | 2017-03-22 | 青岛大学 | Preparation method of composite fiber of cellulose nanometer fibrils/alginate |
| CN107115554A (en) * | 2017-04-28 | 2017-09-01 | 广东泰宝医疗科技股份有限公司 | A kind of efficient hemostasis is dispelled the compound dressing and preparation method thereof of pain |
| CN108283727A (en) * | 2018-03-26 | 2018-07-17 | 广东工业大学 | A kind of nanofiber dressing and preparation method thereof |
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| CN105251045A (en) * | 2015-10-20 | 2016-01-20 | 青岛明月生物医用材料有限公司 | Fucoidin-containing biomedical hydrogel and preparation method thereof |
| CN106521706A (en) * | 2016-11-15 | 2017-03-22 | 青岛大学 | Preparation method of composite fiber of cellulose nanometer fibrils/alginate |
| CN107115554A (en) * | 2017-04-28 | 2017-09-01 | 广东泰宝医疗科技股份有限公司 | A kind of efficient hemostasis is dispelled the compound dressing and preparation method thereof of pain |
| CN108283727A (en) * | 2018-03-26 | 2018-07-17 | 广东工业大学 | A kind of nanofiber dressing and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110184680A (en) * | 2019-05-20 | 2019-08-30 | 青岛大学 | A kind of fucoidin micro Nano material and preparation method thereof |
| WO2021161252A1 (en) * | 2020-02-13 | 2021-08-19 | Bakel S.R.L. | Method of electrospinning natural polymers |
| WO2021161250A1 (en) * | 2020-02-13 | 2021-08-19 | Bakel S.R.L. | Natural composition based on polymers to be electrospun, and method to prepare the same |
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