CN104368032A - Biologic gel material for wound repairing and preparation method of biologic gel material - Google Patents
Biologic gel material for wound repairing and preparation method of biologic gel material Download PDFInfo
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- CN104368032A CN104368032A CN201410641510.7A CN201410641510A CN104368032A CN 104368032 A CN104368032 A CN 104368032A CN 201410641510 A CN201410641510 A CN 201410641510A CN 104368032 A CN104368032 A CN 104368032A
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Abstract
The invention belongs to the field of new biologic materials and discloses a biologic gel material for wound repairing and a preparation method of the biologic gel material. The biologic gel material for the wound repairing comprises Arabic gum, flaxseed gum, oligo-isomaltose, hydroxy propyl cellulose, n-butyl alcohol and water. The preparation method comprises the following steps: (1) dissolving the Arabic gum and the flaxseed gum in water by virtue of stirring, to form a material A; (2) dissolving oligo-isomaltose and hydroxy propyl cellulose in water by virtue of stirring, so as to form a material B; (3) mixing the material A, the material B and n-butyl alcohol, wherein the mixture comprises the following components in percentage by weight: 3wt%-8wt% of Arabic gum, 2wt%-6wt% of flaxseed gum, 0.5wt%-1.5wt% oligo-isomaltose, 1.5wt%-3wt% hydroxy propyl cellulose, 3wt%-6wt% n-butyl alcohol and the balance of water; and uniformly stirring, and cooling so as to obtain the biologic gel material for the wound repairing.
Description
Technical field
The invention belongs to biological material field, relate to a kind of biogel material and preparation method thereof, particularly relate to a kind of wound repair biogel material and preparation method thereof.
Background technology
Wound surface to be normal skin (tissue) in the external world the cause injury factor as surgical operation, external force, heat, electric current, chemical substance, low temperature and body intrinsic factor as under the effects such as local blood supply obstacle the infringement that causes.Normal with the destruction of skin integrity and the loss of a certain amount of normal structure, meanwhile, the normal function of skin is impaired.Also referred to as wound or wound.Wound repair is wound repair both.
Material for wound repair is also more, has organic polymer repair materials, gel rubber material etc.The biocompatibility of organic polymer repair materials is poor, and some high-molecular organic materials also can the symptom of making patients.The advantages such as gel rubber material is used for having extraordinary effect in wound repair, and good breathability, biocompatibility, anthemorrhagic speed be fast as having.License notification number is that the patent of invention of CN CN102698312 discloses a kind of gel rubber material, and it chooses after chitosan solution mixes with Aloe virgin rubber, forms gel after dropwise adding β-sodium glycerophosphate.This gel rubber material has certain effect, but the physical strength of its pick up, gel is lower, needs to be further improved the performance of this gel rubber material.
Summary of the invention
The technical problem solved: the gel rubber material that wound repair uses has compared to some other wrapper material that anthemorrhagic performance is good, the effect of wound healing, the pick up of common wound repair gel rubber material is lower, when stopping blooding, effect is poor, the intensity of gel rubber material common is in addition lower, the object of this invention is to provide a kind of wound repair biogel material and preparation method thereof possessed compared with high-liquid absorbing rate and intensity newly.
Technical scheme: for the problems referred to above, the invention discloses a kind of wound repair biogel material and preparation method thereof.Described wound repair biogel material comprises the composition of following weight parts:
Arabic gum 3wt%-8wt%,
Semen Lini glue 2wt%-6wt%,
Oligomeric isomaltose 0.5wt%-1.5wt%,
Hydroxypropyl cellulose 1.5wt%-3wt%,
N-butyl alcohol 3wt%-6wt%,
Surplus is water.
Described a kind of wound repair biogel material, described wound repair biogel material comprises the composition of following weight parts:
Arabic gum 4wt%-6wt%,
Semen Lini glue 3wt%-5wt%,
Oligomeric isomaltose 0.8wt%-1.2wt%,
Hydroxypropyl cellulose 2wt%-2.6wt%,
N-butyl alcohol 4wt%-5wt%,
Surplus is water.
A preparation method for wound repair biogel material, the preparation method of described wound repair biogel material comprises the following steps:
(1) getting arabic gum, Semen Lini glue temperature is that the water of 50-70 DEG C stirs, be stirred to arabic gum and Semen Lini glue is dissolved in the water sufficiently uniformly, is material A;
(2) separately getting oligomeric isomaltose, hydroxypropyl cellulose again, stir with the water that temperature is 50-70 DEG C, be stirred to oligomeric isomaltose and hydroxypropyl cellulose is dissolved in the water sufficiently uniformly, is material B;
(3) also have n-butyl alcohol to mix material A and material B, each composition is respectively arabic gum 3wt%-8wt%, Semen Lini glue 2wt%-6wt% according to weight percent content, oligomeric isomaltose 0.5wt%-1.5wt%, hydroxypropyl cellulose 1.5wt%-3wt%, n-butyl alcohol 3wt%-6wt%, surplus be water; Stir during mixing, being stirred to evenly, is wound repair biogel material after cooling.
Preferably, the arabic gum described in preparation method, the Semen Lini glue of described a kind of wound repair biogel material are Powdered.
Preferably, get arabic gum in the preparation method step (1) of described a kind of wound repair biogel material, Semen Lini glue temperature is that the water of 60 DEG C stirs.
Preferably, in the preparation method step (3) of described a kind of wound repair biogel material, arabic gum is 4wt%-6wt%.
Preferably, in the preparation method step (3) of described a kind of wound repair biogel material, Semen Lini glue is 3wt%-5wt%.
Preferably, in the preparation method step (3) of described a kind of wound repair biogel material, oligomeric isomaltose is 0.8wt%-1.2wt%.
Preferably, in the preparation method step (3) of described a kind of wound repair biogel material, hydroxypropyl cellulose is 2wt%-2.6wt%.
Preferably, in the preparation method step (3) of described a kind of wound repair biogel material, n-butyl alcohol is 4wt%-5wt%.
Beneficial effect: Semen Lini glue and oligomeric isomaltose are as two kinds of colloidal materials, use in biogel is less, after the present invention verifies by experiment in biogel and adds Semen Lini glue and oligomeric isomaltose, pick up and the mechanical strength of the biogel material of preparation all promote significantly, all higher than common gel rubber material.When arabic gum in biogel material be 4wt%-6wt%, Semen Lini glue is 3wt%-5wt%, oligomeric isomaltose is 0.8wt%-1.2wt%, hydroxypropyl cellulose is 2wt%-2.6wt%, n-butyl alcohol is 4wt%-5wt%, surplus is water time, the performance of the biogel material of preparation is better.
Detailed description of the invention
Embodiment 1
(1) getting arabic gum, Semen Lini glue temperature is that the water of 70 DEG C stirs, be stirred to arabic gum and Semen Lini glue is dissolved in the water sufficiently uniformly, is material A; (2) separately getting oligomeric isomaltose, hydroxypropyl cellulose again, stir with the water that temperature is 70 DEG C, be stirred to oligomeric isomaltose and hydroxypropyl cellulose is dissolved in the water sufficiently uniformly, is material B; (3) also have n-butyl alcohol to mix material A and material B, each composition is respectively arabic gum 3wt%, Semen Lini glue 6wt% according to weight percent content, oligomeric isomaltose 0.5wt%, hydroxypropyl cellulose 3wt%, n-butyl alcohol 3wt%, surplus be water; Stir during mixing, being stirred to evenly, is wound repair biogel material after cooling.
Embodiment 2
(1) getting arabic gum, Semen Lini glue temperature is that the water of 50 DEG C stirs, be stirred to arabic gum and Semen Lini glue is dissolved in the water sufficiently uniformly, is material A; (2) separately getting oligomeric isomaltose, hydroxypropyl cellulose again, stir with the water that temperature is 50 DEG C, be stirred to oligomeric isomaltose and hydroxypropyl cellulose is dissolved in the water sufficiently uniformly, is material B; (3) also have n-butyl alcohol to mix material A and material B, each composition is respectively arabic gum 8wt%, Semen Lini glue 2wt% according to weight percent content, oligomeric isomaltose 1.5wt%, hydroxypropyl cellulose 1.5wt%, n-butyl alcohol 6wt%, surplus be water; Stir during mixing, being stirred to evenly, is wound repair biogel material after cooling.
Embodiment 3
(1) getting arabic gum, Semen Lini glue temperature is that the water of 70 DEG C stirs, be stirred to arabic gum and Semen Lini glue is dissolved in the water sufficiently uniformly, is material A; (2) separately getting oligomeric isomaltose, hydroxypropyl cellulose again, stir with the water that temperature is 70 DEG C, be stirred to oligomeric isomaltose and hydroxypropyl cellulose is dissolved in the water sufficiently uniformly, is material B; (3) also have n-butyl alcohol to mix material A and material B, each composition is respectively arabic gum 4wt%, Semen Lini glue 5wt% according to weight percent content, oligomeric isomaltose 0.8wt%, hydroxypropyl cellulose 2.6wt%, n-butyl alcohol 4wt%, surplus be water; Stir during mixing, being stirred to evenly, is wound repair biogel material after cooling.
Embodiment 4
(1) getting arabic gum, Semen Lini glue temperature is that the water of 50 DEG C stirs, be stirred to arabic gum and Semen Lini glue is dissolved in the water sufficiently uniformly, is material A; (2) separately getting oligomeric isomaltose, hydroxypropyl cellulose again, stir with the water that temperature is 50 DEG C, be stirred to oligomeric isomaltose and hydroxypropyl cellulose is dissolved in the water sufficiently uniformly, is material B; (3) also have n-butyl alcohol to mix material A and material B, each composition is respectively arabic gum 6wt%, Semen Lini glue 3wt% according to weight percent content, oligomeric isomaltose 1.2wt%, hydroxypropyl cellulose 2wt%, n-butyl alcohol 5wt%, surplus be water; Stir during mixing, being stirred to evenly, is wound repair biogel material after cooling.
Embodiment 5
(1) getting arabic gum, Semen Lini glue temperature is that the water of 60 DEG C stirs, be stirred to arabic gum and Semen Lini glue is dissolved in the water sufficiently uniformly, is material A; (2) separately getting oligomeric isomaltose, hydroxypropyl cellulose again, stir with the water that temperature is 60 DEG C, be stirred to oligomeric isomaltose and hydroxypropyl cellulose is dissolved in the water sufficiently uniformly, is material B; (3) also have n-butyl alcohol to mix material A and material B, each composition is respectively arabic gum 5wt%, Semen Lini glue 4wt% according to weight percent content, oligomeric isomaltose 1.0wt%, hydroxypropyl cellulose 2.3wt%, n-butyl alcohol 4.5wt%, surplus be water; Stir during mixing, being stirred to evenly, is wound repair biogel material after cooling.
Comparative example 1
(1) getting arabic gum temperature is that the water of 70 DEG C stirs, and is stirred to arabic gum and Semen Lini glue is dissolved in the water sufficiently uniformly, is material A; (2) separately getting hydroxypropyl cellulose again, stir, be stirred to hydroxypropyl cellulose and be dissolved in the water sufficiently uniformly with the water that temperature is 70 DEG C, is material B; (3) also have n-butyl alcohol to mix material A and material B, each composition is respectively arabic gum 3wt%, hydroxypropyl cellulose 3wt% according to weight percent content, n-butyl alcohol 3wt%, surplus be water; Stir during mixing, being stirred to evenly, is wound repair biogel material after cooling.
Comparative example 2
License notification number is CN102698312: choose 10 years fresh Aloe vulgariss of tissue regeneration promoting, after tap water cleans up, with distilled water cleaning twice, is placed in aseptic operating platform, ultra-vioket radiation sterilizing 30min.After sterilizing completes, get sarcocarp with scalpel stripping blade, sarcocarp, with after juice extractor fragmentation, loads in the centrifuge tube of 50mL, after 15000 turns/min high speed centrifugation 5min, is separated and obtains supernatant, be aseptic Aloe virgin rubber.4g chitosan joins 100mL 3%(v/v) acetum molten in, stirring and dissolving at 40 DEG C, obtain separate 4%(w/v) chitosan solution.Get 50mL chitosan solution to load in 3000kDa dialyzer, at 4 DEG C, be placed in 2L distilled water dialysis 6 days, every other day change water.Then the chitosan solution after dialysis dilution is placed in beaker, is placed on transpiring moisture in 50 DEG C of baking ovens and is concentrated to 50mL, the pH value of the chitosan solution after dialysis purification is about 6.3.Prepare 40%(w/v with distilled water) β-sodium glycerophosphate, with the membrane filtration sterilizing of 0.22um, obtain aseptic β-phosphoglycerol sodium water solution.At 4 DEG C, after the chitosan solution of 4% after dialysis is mixed according to volume ratio 1: 1 with Aloe virgin rubber, stir, then dropwise add β-sodium glycerophosphate, between the pH value 7.2 ~ 7.4 of adjustment solution.Just gel can be formed in 37 DEG C of (body temperature) 5min.
Be film by the equal vacuum drying of gel of embodiment 1 to 5, comparative example 1 and 2, measure its water absorption rate, survey its fracture strength and elongation at break more in addition, result is as following table:
After adding Semen Lini glue and oligomeric isomaltose bi-material, the water absorption rate of wound repair biogel material, fracture strength, elongation at break are all higher than the biogel material not adding Semen Lini glue and oligomeric isomaltose.In addition, in gel rubber material, the proportion of composing of various material also creates larger impact to the gel rubber material of preparation, and the properties of biogel material of the present invention is all better than the gel rubber material in comparative example 1 and comparative example 2.
Claims (10)
1. a wound repair biogel material, is characterized in that, described wound repair biogel material comprises the composition of following weight parts:
Arabic gum 3wt%-8wt%,
Semen Lini glue 2wt%-6wt%,
Oligomeric isomaltose 0.5wt%-1.5wt%,
Hydroxypropyl cellulose 1.5wt%-3wt%,
N-butyl alcohol 3wt%-6wt%,
Surplus is water.
2. a kind of wound repair biogel material according to claim 1, is characterized in that, described wound repair biogel material comprises the composition of following weight parts:
Arabic gum 4wt%-6wt%,
Semen Lini glue 3wt%-5wt%,
Oligomeric isomaltose 0.8wt%-1.2wt%,
Hydroxypropyl cellulose 2wt%-2.6wt%,
N-butyl alcohol 4wt%-5wt%,
Surplus is water.
3. a wound repair preparation method for biogel material, is characterized in that, the preparation method of described wound repair biogel material comprises the following steps:
(1) getting arabic gum, Semen Lini glue temperature is that the water of 50-70 DEG C stirs, be stirred to arabic gum and Semen Lini glue is dissolved in the water sufficiently uniformly, is material A;
(2) separately getting oligomeric isomaltose, hydroxypropyl cellulose again, stir with the water that temperature is 50-70 DEG C, be stirred to oligomeric isomaltose and hydroxypropyl cellulose is dissolved in the water sufficiently uniformly, is material B;
(3) also have n-butyl alcohol to mix material A and material B, each composition is respectively arabic gum 3wt%-8wt%, Semen Lini glue 2wt%-6wt% according to weight percent content, oligomeric isomaltose 0.5wt%-1.5wt%, hydroxypropyl cellulose 1.5wt%-3wt%, n-butyl alcohol 3wt%-6wt%, surplus be water; Stir during mixing, being stirred to evenly, is wound repair biogel material after cooling.
4. the preparation method of a kind of wound repair biogel material according to claim 3, is characterized in that, the arabic gum described in preparation method, the Semen Lini glue of described wound repair biogel material are Powdered.
5. the preparation method of a kind of wound repair biogel material according to claim 3, it is characterized in that, in the preparation method step (1) of described wound repair biogel material, get arabic gum, Semen Lini glue temperature is that the water of 60 DEG C stirs.
6. the preparation method of a kind of wound repair biogel material according to claim 3, is characterized in that, in the preparation method step (3) of described wound repair biogel material, arabic gum is 4wt%-6wt%.
7. the preparation method of a kind of wound repair biogel material according to claim 3, is characterized in that, in the preparation method step (3) of described wound repair biogel material, Semen Lini glue is 3wt%-5wt%.
8. the preparation method of a kind of wound repair biogel material according to claim 3, is characterized in that, in the preparation method step (3) of described wound repair biogel material, oligomeric isomaltose is 0.8wt%-1.2wt%.
9. the preparation method of a kind of wound repair biogel material according to claim 3, is characterized in that, in the preparation method step (3) of described wound repair biogel material, hydroxypropyl cellulose is 2wt%-2.6wt%.
10. the preparation method of a kind of wound repair biogel material according to claim 3, is characterized in that, in the preparation method step (3) of described wound repair biogel material, n-butyl alcohol is 4wt%-5wt%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106478963A (en) * | 2016-10-11 | 2017-03-08 | 中国农业科学院油料作物研究所 | Flaxseed gum/cellulose composite aquogel and preparation method thereof |
| CN113244455A (en) * | 2021-05-17 | 2021-08-13 | 广西医科大学 | 3D printing flaxseed hydrogel support and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040153040A1 (en) * | 2003-02-05 | 2004-08-05 | Lucie Martineau | Multi-layer synthetic dressing with cooling characteristics |
| CN1947801A (en) * | 2006-01-27 | 2007-04-18 | 邢宪生 | Composite function liquid wound dressing and its use |
| US20090010998A1 (en) * | 2007-07-03 | 2009-01-08 | Marchitto Kevin S | Drug-delivery patch comprising a dissolvable layer and uses thereof |
| CN102036691A (en) * | 2008-04-24 | 2011-04-27 | 桑尼维普斯Pty有限公司 | Disinfecting formulation |
| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| CN103611184A (en) * | 2013-11-27 | 2014-03-05 | 长春吉原生物科技有限公司 | Hydrogel of composite semipermeable membrane and preparation method thereof |
-
2014
- 2014-11-14 CN CN201410641510.7A patent/CN104368032B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040153040A1 (en) * | 2003-02-05 | 2004-08-05 | Lucie Martineau | Multi-layer synthetic dressing with cooling characteristics |
| CN1947801A (en) * | 2006-01-27 | 2007-04-18 | 邢宪生 | Composite function liquid wound dressing and its use |
| US20090010998A1 (en) * | 2007-07-03 | 2009-01-08 | Marchitto Kevin S | Drug-delivery patch comprising a dissolvable layer and uses thereof |
| CN102036691A (en) * | 2008-04-24 | 2011-04-27 | 桑尼维普斯Pty有限公司 | Disinfecting formulation |
| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| CN103611184A (en) * | 2013-11-27 | 2014-03-05 | 长春吉原生物科技有限公司 | Hydrogel of composite semipermeable membrane and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 熊亚兰等: ""低聚异麦芽糖凝胶防治大鼠霉菌性阴道炎的研究"", 《华西药学杂志》, vol. 29, no. 4, 31 August 2014 (2014-08-31), pages 392 - 395 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106478963A (en) * | 2016-10-11 | 2017-03-08 | 中国农业科学院油料作物研究所 | Flaxseed gum/cellulose composite aquogel and preparation method thereof |
| CN113244455A (en) * | 2021-05-17 | 2021-08-13 | 广西医科大学 | 3D printing flaxseed hydrogel support and preparation method and application thereof |
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| CN104368032B (en) | 2016-08-24 |
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Inventor after: Li Donghang Inventor after: Jin Zhongen Inventor after: Quan Chunlan Inventor after: Zhang Fan Inventor before: Jin Zhongen Inventor before: Quan Chunlan Inventor before: Zhang Fan |
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Effective date of registration: 20160701 Address after: 100085, Beijing, Haidian District Road, No. 5, 3, A305 Applicant after: Aojing Medicine, Sci. & Tech. Co., Ltd., Beijing Address before: 215163 Suzhou province high tech Zone Longshan Road, No. 10, Jiangsu Applicant before: Suzhou Koumei New Material Co., Ltd. |
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Address after: 100085, Beijing, Haidian District Road, No. 5, 3, A305 Patentee after: Aojing Medical Technology Co., Ltd Address before: 100085, Beijing, Haidian District Road, No. 5, 3, A305 Patentee before: Beijing Allgens Medical Science and Technology Co.,Ltd. |