CN114652884A

CN114652884A - Camellia soothing essence disposable hygienic product nursing base material, preparation method and application

Info

Publication number: CN114652884A
Application number: CN202210301885.3A
Authority: CN
Inventors: 许旭芳
Original assignee: Kingdom Healthcare Holdings Ltd Guangdong
Current assignee: Kingdom Healthcare Holdings Ltd Guangdong
Priority date: 2022-03-24
Filing date: 2022-03-24
Publication date: 2022-06-24
Anticipated expiration: 2042-03-24
Also published as: CN114652884B

Abstract

The invention discloses a camellia soothing essence disposable hygienic product nursing base material, a preparation method and application, wherein the camellia soothing essence disposable hygienic product nursing base material is prepared from the following raw materials: camellia extract, a microemulsion efficacy emulsifier, a polygonatum extract, a thickening agent, a humectant, an accelerant, an anti-allergy agent, a solubilizer, a non-irritant preservative composition and pure water. The components of the sanitary towel are mutually cooperated, so that the prepared sanitary towel can obviously reduce the irritation and pain and itch discomfort of female pudendum and relieve the symptoms of pudendum inflammation, pudendum itch, irritation and the like; the preparation method comprises the preparation of the components A and B and the mixed discharge, wherein the microemulsion functional emulsifier has fine grain diameter and is easy to absorb, and can better permeate the effective components into the skin, nourish the vulva skin and keep the vitality of the functional components; in addition, the polygonatum extract contains viscous saponin, and generates a certain synergistic effect with sclerotium rolfsii gum, so that silky smooth texture is brought to skin, and the prepared sanitary towel is not silky and sticky.

Description

Camellia soothing essence disposable hygienic product nursing base material, preparation method and application

Technical Field

The invention relates to a disposable hygienic product nursing base material, in particular to a camellia soothing essence disposable hygienic product nursing base material, a preparation method and application.

Background

Sanitary towel (pad) and sanitary pants product are close to vulva skin, women's vulva can cause vulva red and swollen, pain and itch discomfort and other feelings because of being in moist and sultry environment for a long time, and the long-time contact of chemical substances is easy to be stimulated and allergic, when the bacterial quantity is too much, inflammation is easy to be induced and discomfort is produced, and the life quality of women is seriously influenced by the problems.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention provides a camellia soothing essence disposable hygienic product nursing base material, a preparation method and application

The technical scheme adopted by the invention for solving the technical problems is as follows:

a camellia soothing essence disposable hygienic product nursing base material is prepared from the following raw materials in parts by weight: 6.0-10.0 parts of camellia extract, 2.0-5.0 parts of microemulsion efficacy emulsifier, 5.0-10.0 parts of polygonatum extract, 0.05-0.2 part of thickener, 5.0-10.0 parts of humectant, 0.1-1.0 part of accelerant, 0.1-1.0 part of anti-allergic agent, 1.0-5.0 parts of solubilizer, 0.5-1.0 part of non-irritant preservative combination and 56.8-80.75 parts of pure water.

The microemulsion functional emulsifier is prepared from the following raw materials in parts by weight: 10-15 parts of butanediol, 10-15 parts of hydrogenated castor oil, 1-3 parts of hydrogenated polyisobutene, 3-5 parts of cetyl ethyl hexanoate, 15-20 parts of sodium dilysine, 1-3 parts of phenoxyethanol and 50-60 parts of pure water.

The thickening agent is sclerotium rolfsii gum.

The humectant is butanediol.

The promoter is naringenin.

The anti-allergic agent is a mixture of centella asiatica extract and cyclodextrin in any proportion.

The solubilizer is polysorbate-80.

The non-irritating and antiseptic composition is a mixture of glyceryl caprylate, caprylyl hydroxamic acid, p-hydroxyacetophenone and butanediol in the same proportion.

A method of making a care substrate as described above, comprising the steps of:

(1) and preparation of component A: adding the microemulsion effect emulsifier, the camellia extract and the polygonatum extract in parts by weight into a stirrer A, and then mixing for 5-10 minutes at the rotating speed of 50-60 revolutions per minute to obtain the component A.

(2) And preparation of component B: adding the accelerator, the humectant, the anti-allergic agent, the solubilizer and the non-irritant anticorrosion composition into the stirrer B in parts by weight, and then mixing for 5-10 minutes at the rotating speed of 50-60 revolutions per minute to obtain the component B.

(3) And mixed discharging: adding the pure water in parts by weight into a main stirring kettle, adding the component A into the main stirring kettle, keeping the rotation speed at 50-60 rpm, stirring for 15-25 minutes, heating the main stirring kettle to 45 ℃ while stirring, adding the component B into the main stirring kettle at 45 ℃, keeping the rotation speed at 50-60 rpm, stirring for 5-10 minutes, adding the thickening agent in parts by weight into the main stirring kettle, keeping the rotation speed at 50-60 rpm, stirring for 15-25 minutes, standing, and discharging.

A sanitary towel applying the nursing substrate is prepared by the following process: and spraying the camellia soothing essence disposable sanitary product nursing base material on the non-woven fabric on the surface layer of the sanitary towel, then carrying out roller extrusion on the non-woven fabric, and then drying at the drying temperature of 80-85 ℃ to obtain the camellia soothing essence disposable sanitary towel.

The invention has the beneficial effects that: the camellia extract, the polygonatum extract, the centella extract, the naringenin, the microemulsion emulsifier, the thickener, the humectant, the solubilizer and the non-irritating and antiseptic combination are added into the sanitary towel (pad) and the sanitary pants, and all the components are mutually cooperated, so that the prepared sanitary towel (pad) and the sanitary pants can obviously reduce the irritation and pain and itch discomfort of the female pudendum, and relieve the symptoms of pudendum inflammation, pudendum itch, stabbing pain and the like; the microemulsion-effect emulsifier has small particle size and easy absorption, can better permeate effective components into skin, can moisten vulvar skin and keep the activity of the effective components; in addition, the polygonatum extract contains viscous saponin, and generates a certain synergistic effect with the sclerotium rolfsii gum, so that silky smooth texture is brought to the skin, and the prepared sanitary towel (pad) and sanitary pants are not easy to be silky and sticky.

Drawings

The invention is further illustrated with reference to the following figures and examples.

FIG. 1 is a graph of the antioxidant assay results of Camellia japonica extract;

FIG. 2 is a graph showing the anti-inflammatory assay results of Camellia japonica extract;

FIG. 3 is a graph showing the results of testing camellia extract against contaminants;

FIG. 4 is a graph of the results of a camellia extract on human skin irritation test;

FIG. 5 is a graph of a camellia extract stability test;

FIG. 6 is a test chart of moisturizing function of Yuzhu extract;

FIG. 7 is a test chart of the inhibition of alpha-MSH-induced melanin synthesis by Polygonatum odoratum extract.

Detailed Description

In all examples of the present invention, the temperature and pressure are not particularly emphasized and are both normal temperature and normal pressure, and the equipment use is not particularly described and may be used in a conventional manner.

Referring to fig. 1 to 7, a camellia soothing essence sanitary towel (panty liner) and sanitary pant nursing base material is prepared from the following raw materials in percentage by weight: 6.0-10.0 percent of camellia extract, 2.0-5.0 percent of microemulsion emulsifier, 5.0-10.0 percent of MUSAP fragrant solomonseal rhizome extract, 0.05-0.2 percent of thickening agent, 5.0-10.0 percent of humectant, 0.1-1.0 percent of accelerant, 0.1-1.0 percent of anti-allergic agent, 1.0-5.0 percent of solubilizer, 0.5-1.0 percent of non-irritant preservative composition and the balance of pure water.

The camellia extract is selected from "wintersweet" from jizhou island, wintersweet being one of the most well-known camellia species, also known as winter rose, which is a flowering small tree, native to korea and japan, which is commonly referred to as "Dongbaek" in korea and "Tsubaki" in japan, which is one of the primary plants grown in jizhou island. Therefore, people are also called Jizhou island as the island of the hiba cypress tree. The camellia extract (redsinow) is prepared by washing, steam extracting, collecting, standing, filtering, QC experiment and packaging. The extraction method of the camellia extract is a conventional method and the method is known.

As shown in FIG. 1, the antioxidant effect of Camellia extract (RedSnow) was tested. Both DPPH and ABTS showed concentration-dependent increase, and showed excellent antioxidant effect at 500ppm and 1000ppm concentrations.

As shown in FIG. 2, anti-inflammatory effects of Camellia extract (RedSnow) were measured. Induction of inflammatory cell growth factor: LPS or lL-4. RedSnow significantly inhibited the induction of inflammatory factors such as Nitric Oxide (NO) and Eotaxin-1, and RedSnow reduced the expression of cyclooxygenase (COX-2). RedSnow promotes collagen synthesis.

As shown in FIG. 3, Camellia extract (RedSnow) is effective against the problem of skin aging caused by contaminants. RedSnow shows a rather good efficacy against skin aging caused by pollutant stress. Note that: d5: standing for 5 days; PD 5: mixture of heavy metals and hydrocarbon compounds + standing for 5 days; general Morphology: morphology; collagen I: collagen protein; MMP-1: a collagenase; MDA: malondialdehyde; cells with pycnotic core, preservation of DEJ deletion: cell nuclei are fixed and contracted, and DEJ is prevented from being separated; collagen diversity: a collagen density; slight: slightly; moderate: medium; quite Clear: clearly; SB: an upper base layer; a BL base layer.

As shown in fig. 4: no irritation was confirmed in the patch test. The primary stimulation test of human shows that no stimulation response occurs to human skin. Note that: reaction grade standards: a reaction scoring criterion; squalane: squalane; RedSnow: camellia extract.

As shown in fig. 5: under extreme ultraviolet and thermal conditions, the color and content are not changed obviously, and the stability is maintained. The microemulsion functional emulsifier is prepared from the following raw materials in parts by weight: butanediol, hydrogenated castor oil, hydrogenated polyisobutene, cetyl ethylhexanoate, sodium dilysine, phenoxyethanol and pure water.

The microemulsion efficacy emulsifier is butanediol (chemical formula is C)₄H₁₀O₂)10-15 parts of hydrogenated castor oil (preferably Cao in North lake)10-15 parts of PEG-60 hydrogenated castor oil produced by scientific and technological limited company, 1-3 parts of hydrogenated polyisobutene (preferably produced by Hubei Xin Rundy chemical Co., Ltd.), 3-5 parts of cetyl ethyl hexanoate (preferably produced by Kandis chemical (Hubei)) 15-20 parts of sodium dilysine (also called sodium bis (lauramide glutamine) lysine produced by Guangzhou Kogyo Co., Ltd.), and phenoxyethanol (the molecular formula is C8H)₁₀O₂)1-3 parts of pure water (any one of deionized water, pure water, distilled water and pure water) and 50-60 parts of pure water. The microemulsion effect emulsifier has fine particle size and easy absorption, can better permeate effective components into skin, can moisten vulvar skin, and keeps the activity of the effective components.

The preparation process of the microemulsion efficacy emulsifier comprises the following steps: preheating a reaction kettle, heating the reaction kettle to 50-60 ℃, adding the hydrogenated castor oil, the hydrogenated polyisobutene, the cetyl ethylhexanoate and the phenoxyethanol in parts by weight, and stirring for 15-20min at the stirring speed of 60-65r/min to obtain an oil phase; after stirring, adding butanediol, sodium dilysine and pure water, continuing to react for 20-25min, keeping the stirring speed of 60-65r/min and the reaction temperature of 50-60 ℃, then cooling to room temperature, and standing to obtain the microemulsion effect emulsifier.

The polygonatum odoratum extract (MUSAP) can brighten, whiten and lustrous the skin according to the traditional Chinese medicine. Yuzhu contains a large amount of mucus, carbohydrate, starch (more than about 60%) and saponin. Polygonatum odoratum can be used as herbal medicine for treating intestinal problems, pain, rheumatism and gout, and as diuretic. Polygonatum odoratum (Polygonatum odoratum) extracts obtained by extracting with different solvents have different appearance characteristics. Therefore, only the ethanol aqueous solution within the specific range can be extracted to obtain the polygonatum odoratum extract with better viscosity. The polygonatum extract is prepared by extracting with ethanol water solution, filtering, concentrating, purifying and reconstructing. The extraction method of the polygonatum extract is a conventional method and the method is known.

As shown in fig. 6: the rhizoma Polygonati Odorati extract has moisture keeping effect. Note that: MUSAP is extract of rhizoma Polygonati Odorati.

As shown in fig. 7: polygonatum odoratum extract inhibits alpha-MSH-induced melanin synthesis. Note that: melanogenesis inhibition: inhibition; control: contrast control; on mouse melanoma cell: a melanoma cell.

The thickening agent is sclerotium rolfsii gum (produced by Shandong Changzhao new material Co., Ltd.). The sclerotium rolfsii gum is cooperated with polygonatum mucopolysaccharide (odoratan) and 4 polygonatum fructans (polygland-fructan-O-A, B, C and D) in the polygonatum extract to improve the viscosity of A system, so that the system is kept in A uniform and stable suspension state or an emulsion state; the rhizoma Polygonati Odorati extract also contains viscous saponin, and can provide silky texture to skin, and the obtained sanitary towel has no tendency to get silky and sticky.

The humectant is butanediol (chemical formula is C)₄H₁₀O₂). Butylene glycol is a hydrophilic emollient substance that has the ability to bind water in the lower humidity range, moisturizing the skin, and it serves to reduce skin dryness by maintaining the skin in a state of equilibrium at a higher than normal water content by controlling the exchange of moisture between the product and the ambient air.

The promoter is naringenin (molecular formula is C)₁₅H₁₂O5). Naringenin has antibacterial effect on Staphylococcus epidermidis, Staphylococcus aureus, Bacillus subtilis, Flavobacterium and Escherichia coli. Naringenin can reduce the production of HCV-infected hepatovirus cultured in vitro. This may be secondary to the effect of naringenin in inhibiting secretion of very low density lipoproteins. Naringenin also has significant antioxidant properties. It has been shown to reduce oxidative damage to DNA in vitro and in animal studies. The naringenin can be combined with the non-irritant anticorrosion agent to generate an excellent compatibility effect, and the anticorrosion and antibacterial properties of the system can be improved.

The anti-allergic agent is herba Centellae extract (herba Centellae extract produced by Shanyang Bifeng Biotech. Limited liability company) and cyclodextrin (molecular formula is C)₄₂H₇₀O₃₅) Mixtures in any proportion. Can effectively relieve irritation and pain and itch of female pudendum, and relieve pudendum inflammation, pudendum itch, irritation, etc.

The solubilizer is polysorbate-80 (chemical)Formula is C₆₄H₁₂₄O₂₆). Polysorbate-80 is an excellent O/W emulsifier, and the emulsifying capacity is slightly influenced by high-concentration electrolyte and pH value change. Has good emulsification effect on vegetable oil, mineral oil, animal fat and the like. Has good solubilizing effect on both non-polar compounds and compounds containing polar groups.

The non-irritant and antiseptic composition comprises glyceryl caprylate (produced by Guangzhou Dada New Material Co., Ltd.) and caprylyl hydroximic acid (chemical formula C)₈H₁₇NO₂) P-hydroxyacetophenone (molecular formula C)₈H₈O₂) And butanediol (formula C)₄H₁₀O₂) A mixture of (a). The adopted raw materials are mild raw materials, and have no stimulation to skin, and the stimulation-free and antiseptic combination can endow the product with excellent antiseptic performance, and prolong the storage time of the product.

A method for preparing the camellia soothing essence sanitary towel (panty liner) and the sanitary pant nursing base material comprises the following steps:

1) adding the microemulsion effect emulsifier, the camellia extract and the polygonatum extract in parts by weight into a stirrer A, and then mixing for 5-10 minutes at the rotating speed of 50-60 revolutions per minute to obtain the component A.

2) Adding the accelerator, the humectant, the anti-allergic agent, the solubilizer and the non-irritant anticorrosion composition into a stirrer B in parts by weight, and then mixing for 5-10 minutes at the rotating speed of 50-60 revolutions per minute to obtain a component B.

3) Adding the pure water in parts by weight into a main stirring kettle, adding the component A into the main stirring kettle, keeping the rotation speed at 50-60 rpm, stirring for 15-25 minutes, heating the main stirring kettle to 45 ℃ while stirring, adding the component B into the main stirring kettle at the temperature of below 45 ℃, keeping the rotation speed at 50-60 rpm, stirring for 5-10 minutes, adding the thickening agent in parts by weight into the main stirring kettle, keeping the rotation speed at 50-60 rpm, stirring for 15-25 minutes, standing, and discharging.

A sanitary towel applying the nursing base material is characterized in that the preparation process comprises the following steps: and spraying the camellia soothing essence disposable sanitary product nursing base material on the non-woven fabric on the surface layer of the sanitary towel, then carrying out roller extrusion on the non-woven fabric, and then drying at the drying temperature of 80-85 ℃ to obtain the camellia soothing essence sanitary towel.

Actual use test of volunteers:

volunteers were recruited in a hospital gynecological clinic under the following conditions: the sanitary towel has pudendum sensitive constitution, 400 female volunteers are recruited together, and divided into 5 groups according to regions, 80 persons in each group are randomly divided into 2 groups, namely a test group 1 and a test group 2, the test group 1 uses the sanitary towel prepared in the embodiment 1-3, the test group 2 uses a foreign brand certain antibacterial sanitary towel (pad) and sanitary trousers, and the number of samples is counted according to the physiological period of three months.

The sanitary towel (pad) and the sanitary trousers used in the test are all torn off with the marked substances such as trademarks, and the volunteers do not know which kind of sanitary towel (pad) and sanitary trousers are used by themselves, and need to provide own use feeling for the experimenters after the menstruation ends. The use experience comprises: whether the pudendum is fresh and cool, whether the vagina is painful and itchy, whether the leucorrhea is reduced, whether discomfort in the menstrual period is relieved, whether the discomfort is experienced with the sanitation and whether the discomfort is experienced with the friction feeling are graded, each full grade is 10 points, the better the feeling is, the higher the grade is, and the average score of three times in the three menstrual periods of each group of volunteers is calculated. The test results are shown in the following table:

from the table data, it can be seen that: the test group 1 using the sanitary napkin (panty liner) and the sanitary pants of examples 1 to 3 was significantly superior to the test group 2 in refreshing pudendal region, alleviating itching, alleviating discomfort during menstruation, reducing the sensation of rubbing with the sanitary, and the like. Therefore, the nutrient components of the sanitary towel (pad) prepared from the camellia soothing essence and the sanitary towel (pad) prepared from the sanitary pants nursing base material can be absorbed by the skin of the vulva when the sanitary towel (pad) is used, the activity of skin cells can be enhanced, the symptoms such as pudendum inflammation and the like can be relieved, the skin feels silky after use, and the purpose of nourishing the skin and balancing the microecology of the skin is achieved.

In the description herein, the description of the terms "one embodiment," "some embodiments," "specific embodiments," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the claims and their equivalents.

Claims

1. A camellia soothing essence disposable hygienic product nursing base material is characterized by being prepared from the following raw materials in parts by weight: 6.0-10.0 parts of camellia extract, 2.0-5.0 parts of microemulsion efficacy emulsifier, 5.0-10.0 parts of polygonatum extract, 0.05-0.2 part of thickener, 5.0-10.0 parts of humectant, 0.1-1.0 part of accelerant, 0.1-1.0 part of anti-allergic agent, 1.0-5.0 parts of solubilizer, 0.5-1.0 part of non-irritant preservative combination and 56.8-80.75 parts of pure water.

2. The care substrate according to claim 1, wherein the microemulsion efficacy emulsifier is prepared from the following raw materials in parts by weight: 10-15 parts of butanediol, 10-15 parts of hydrogenated castor oil, 1-3 parts of hydrogenated polyisobutene, 3-5 parts of cetyl ethyl hexanoate, 15-20 parts of sodium dilysine, 1-3 parts of phenoxyethanol and 50-60 parts of pure water.

3. The care substrate of claim 1, wherein the thickening agent is sclerotium rolfsii gum.

4. The care substrate of claim 1, wherein the humectant is butylene glycol.

5. The care substrate of claim 1, wherein the enhancer is naringenin.

6. The care substrate according to claim 1, characterized in that the anti-sensitivity agent is a mixture of centella asiatica extract and cyclodextrin in any ratio.

7. The care substrate according to claim 1, characterized in that the solubilizer is polysorbate-80.

8. The care substrate of claim 1, characterized in that the non-irritating preservative combination is a mixture of glyceryl caprylate, caprylhydroxamic acid, p-hydroxyacetophenone, and butylene glycol in the same proportions.

9. A process for preparing a care substrate according to any of claims 1 to 8, characterized by the following steps:

(1) and preparation of component A: adding the microemulsion functional emulsifier, the camellia extract and the polygonatum extract in parts by weight into a stirrer A, and then mixing for 5-10 minutes at the rotating speed of 50-60 revolutions per minute to prepare a component A;

(2) and preparation of component B: adding the accelerator, the humectant, the anti-allergic agent, the solubilizer and the non-irritant anti-corrosion composition in parts by weight into a stirrer B, and then mixing for 5-10 minutes at a rotating speed of 50-60 revolutions per minute to prepare a component B;

10. A sanitary napkin employing a care substrate according to any one of claims 1 to 8, characterized in that it is prepared by the process of: and spraying the camellia soothing essence disposable sanitary product nursing base material on the non-woven fabric on the surface layer of the sanitary towel, then carrying out roller extrusion on the non-woven fabric, and then drying at the drying temperature of 80-85 ℃ to obtain the camellia soothing essence sanitary towel.