CN111135108A - Compound preservative containing amino acid derivatives, preparation method thereof and cosmetics - Google Patents
Compound preservative containing amino acid derivatives, preparation method thereof and cosmetics Download PDFInfo
- Publication number
- CN111135108A CN111135108A CN202010041667.1A CN202010041667A CN111135108A CN 111135108 A CN111135108 A CN 111135108A CN 202010041667 A CN202010041667 A CN 202010041667A CN 111135108 A CN111135108 A CN 111135108A
- Authority
- CN
- China
- Prior art keywords
- amino acid
- acid derivative
- compound preservative
- caprylyl
- lauroyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003755 preservative agent Substances 0.000 title claims abstract description 81
- 230000002335 preservative effect Effects 0.000 title claims abstract description 77
- 150000001875 compounds Chemical class 0.000 title claims abstract description 50
- 150000003862 amino acid derivatives Chemical class 0.000 title claims abstract description 40
- 239000002537 cosmetic Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title abstract description 8
- -1 caprylyl amino Chemical group 0.000 claims abstract description 54
- 150000002009 diols Chemical group 0.000 claims abstract description 20
- 239000002904 solvent Chemical group 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 235000001014 amino acid Nutrition 0.000 claims description 36
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 21
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 230000003472 neutralizing effect Effects 0.000 claims description 17
- SAVLIIGUQOSOEP-UHFFFAOYSA-N N-octanoylglycine Chemical compound CCCCCCCC(=O)NCC(O)=O SAVLIIGUQOSOEP-UHFFFAOYSA-N 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 8
- 239000004471 Glycine Substances 0.000 claims description 8
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 8
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 6
- GYDYJUYZBRGMCC-INIZCTEOSA-N (2s)-2-amino-6-(dodecanoylamino)hexanoic acid Chemical compound CCCCCCCCCCCC(=O)NCCCC[C@H](N)C(O)=O GYDYJUYZBRGMCC-INIZCTEOSA-N 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- JCQLZKNHLVROBO-JTQLQIEISA-N (2s)-2-(octanoylamino)pentanedioic acid Chemical compound CCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O JCQLZKNHLVROBO-JTQLQIEISA-N 0.000 claims description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 4
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 claims description 4
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 3
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 3
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- GGCVGFFRMZLQBP-LBPRGKRZSA-N (2s)-6-amino-2-(octanoylamino)hexanoic acid Chemical compound CCCCCCCC(=O)N[C@H](C(O)=O)CCCCN GGCVGFFRMZLQBP-LBPRGKRZSA-N 0.000 claims description 2
- FSKNXCHJIFBRBT-UHFFFAOYSA-N 2-[2-[2-(dodecylamino)ethylamino]ethylamino]acetic acid Chemical compound CCCCCCCCCCCCNCCNCCNCC(O)=O FSKNXCHJIFBRBT-UHFFFAOYSA-N 0.000 claims description 2
- FDKNTODVCFVEDJ-UHFFFAOYSA-N 2-[3-(dodecylamino)propylamino]acetic acid Chemical compound CCCCCCCCCCCCNCCCNCC(O)=O FDKNTODVCFVEDJ-UHFFFAOYSA-N 0.000 claims description 2
- AEDQNOLIADXSBB-UHFFFAOYSA-N 3-(dodecylazaniumyl)propanoate Chemical compound CCCCCCCCCCCCNCCC(O)=O AEDQNOLIADXSBB-UHFFFAOYSA-N 0.000 claims description 2
- 150000004985 diamines Chemical class 0.000 claims description 2
- JRBPAEWTRLWTQC-UHFFFAOYSA-N dodecylamine Chemical compound CCCCCCCCCCCCN JRBPAEWTRLWTQC-UHFFFAOYSA-N 0.000 claims description 2
- 229940096989 lauryl aminopropylglycine Drugs 0.000 claims description 2
- 229960002449 glycine Drugs 0.000 claims 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 14
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract description 8
- 244000005700 microbiome Species 0.000 abstract description 7
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract description 7
- 230000002421 anti-septic effect Effects 0.000 abstract description 4
- 210000000170 cell membrane Anatomy 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 238000004945 emulsification Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 14
- 241000894006 Bacteria Species 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 239000006071 cream Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 241000191967 Staphylococcus aureus Species 0.000 description 6
- 230000001815 facial effect Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 238000006386 neutralization reaction Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- XYYUAOIALFMRGY-UHFFFAOYSA-N 3-[2-carboxyethyl(dodecyl)amino]propanoic acid Chemical compound CCCCCCCCCCCCN(CCC(O)=O)CCC(O)=O XYYUAOIALFMRGY-UHFFFAOYSA-N 0.000 description 3
- 241000228245 Aspergillus niger Species 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 150000002332 glycine derivatives Chemical class 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 108700004121 sarkosyl Proteins 0.000 description 3
- 241000228212 Aspergillus Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 108010058846 Ovalbumin Proteins 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 241000223261 Trichoderma viride Species 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 229940051368 capryloyl glycine Drugs 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 210000002390 cell membrane structure Anatomy 0.000 description 2
- 239000012459 cleaning agent Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 2
- 229940092253 ovalbumin Drugs 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- KIUKXJAPPMFGSW-YXBJCWEESA-N (2s,4s,5r,6s)-6-[(2s,3r,5s,6r)-3-acetamido-2-[(3s,4r,5r,6r)-6-[(3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@@H]3[C@@H]([C@@H](O)C(O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)C(C(O)=O)O1 KIUKXJAPPMFGSW-YXBJCWEESA-N 0.000 description 1
- JPYYAMAZLDVDFQ-UHFFFAOYSA-N 2-[2,2-diaminoethyl(octyl)amino]acetic acid hydrochloride Chemical compound Cl.C(CCCCCCC)N(CC(=O)O)CC(N)N JPYYAMAZLDVDFQ-UHFFFAOYSA-N 0.000 description 1
- JKXYOQDLERSFPT-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO JKXYOQDLERSFPT-UHFFFAOYSA-N 0.000 description 1
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000589513 Burkholderia cepacia Species 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- AXISYYRBXTVTFY-UHFFFAOYSA-N Isopropyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC(C)C AXISYYRBXTVTFY-UHFFFAOYSA-N 0.000 description 1
- 244000134336 Malus baccata Species 0.000 description 1
- 235000005079 Malus baccata Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 1
- 108010020346 Polyglutamic Acid Proteins 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000002216 antistatic agent Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 229940065859 sodium cocoyl glycinate Drugs 0.000 description 1
- 229940083608 sodium hydroxide Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 description 1
- RLJSXMVTLMHXJS-UHFFFAOYSA-M sodium;4-decylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCC1=CC=C(S([O-])(=O)=O)C=C1 RLJSXMVTLMHXJS-UHFFFAOYSA-M 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a compound preservative containing amino acid derivatives, which comprises the amino acid derivatives, 1, 2-vicinal diol and a solvent, wherein the amino acid derivatives are caprylyl amino acid derivatives and/or lauroyl amino acid derivatives. The invention can interfere the physiological environment of the cell membrane, namely selectively gather on the water-oil interface in the oil-in-water emulsification system, so that the food source of the microorganism in the area is changed to be unfavorable for the growth of the microorganism, thereby inhibiting the growth of the microorganism; after the 1, 2-vicinal diol is compounded with the caprylyl amino acid derivative and the lauroyl amino acid derivative dissolved in the solvent, a synergistic effect is generated, and the antiseptic and bacteriostatic effects of an octyl chain in the caprylyl amino acid derivative and a lauryl chain in the lauroyl amino acid derivative can be improved, so that the compound preservative has a good antiseptic and bacteriostatic effect and is very safe and mild to use. The invention also provides a preparation method of the compound preservative and cosmetics containing the compound preservative.
Description
Technical Field
The invention relates to the technical field of preservatives, in particular to a compound preservative containing amino acid derivatives, a preparation method thereof and cosmetics containing the compound preservative.
Background
Preservatives are one of the indispensable ingredients of cosmetics, and ensure that the cosmetics are not deteriorated by contamination with microorganisms during production, storage and use. In recent years, more and more consumers use cosmetics to improve the image and beautify themselves. Although the existing preservative has a certain preservative effect, the preservative has a certain stimulation effect on skin, and the preservative effect is not ideal. Therefore, the development of a mild, safe and efficient preservative system has very important practical significance.
The prior art discloses a multifunctional facial cleanser and a preparation method thereof, and the multifunctional facial cleanser is recorded to contain a thickening agent, isononyl isononanoate, glycerol, caprylyl glycine, lauroyl sarcosine, sodium cocoyl glycinate, polyethylene glycol-1500, sodium hydroxide, sodium cocoyl malate, pineapple ferment, sodium decyl benzene sulfonate, a deodorant, a skin penetrating agent, a preservative, a natural perfume extract and water. The preservative selected in the prior art is ovalbumin or a modified substance thereof, is used for replacing the traditional preservatives such as phenoxyethanol and the like which have certain probability of causing allergy to human bodies, and is suitable for vast people with allergic constitution.
Disclosure of Invention
The invention aims to provide a compound preservative containing amino acid derivatives and a preparation method thereof, and the prepared compound preservative containing amino acid derivatives has good preservative and bacteriostatic effects, and is very safe and mild.
The invention also aims to provide a cosmetic which has good antiseptic and bacteriostatic effects.
In order to achieve the purpose, the invention adopts the following technical scheme:
in one aspect, the compound preservative containing the amino acid derivative comprises the amino acid derivative, 1, 2-vicinal diol and a solvent, wherein the amino acid derivative is an octanoyl amino acid derivative and/or a lauroyl amino acid derivative.
Wherein, octyl chain in caprylyl amino acid derivative and lauryl chain in lauroyl amino acid derivative can promote degradation of cell membrane structure; specifically, the carbon chain lengths of the octyl and lauryl chains can be combined with the microbial cell structure to interfere with the physiological environment of the suppressor cell membrane, i.e., selectively accumulate at the water-oil interface in an oil-in-water emulsified system, so that the food source of the microbes in this region is changed to be unfavorable for the growth of the microbes, thereby suppressing the growth of the microbes. The 1, 2-vicinal diol can be used as an additive-free preservative, and can generate a synergistic effect after being compounded with the caprylyl amino acid derivative and the lauroyl amino acid derivative dissolved in a solvent, so that the preservative and bacteriostatic effects of an octyl chain in the caprylyl amino acid derivative and a lauryl chain in the lauroyl amino acid derivative can be improved.
Caprylyl glycine and lauroyl sarcosine disclosed in the formula of the multifunctional face cleansing milk described in the prior art are not used as preservatives, but ovalbumin or modified products thereof are selected as preservatives, so that the person skilled in the art does not consider that caprylyl glycine and lauroyl sarcosine have a preservative effect in cosmetics, and needs to use other preservatives to enable the cosmetics to have the preservative effect. The application just overcomes the prejudice of the technical personnel in the field, and through repeated research, the discovery shows that the antiseptic and bacteriostatic effects of the single addition of the amino acid derivatives of the caprylyl amino acid derivatives and/or the lauroyl amino acid derivatives into the cosmetics are poor, but after the amino acid derivatives containing the caprylyl amino acid derivatives and/or the lauroyl amino acid derivatives are compounded with the 1, 2-vicinal diol and the solvent, the carbon chains of the caprylyl chain and the lauryl chain can be rapidly combined with the cell structure of the microorganism, and the growth of the microorganism can be effectively inhibited. The research shows that the compound preservative has broad-spectrum antibacterial effect and can replace the traditional preservative to be applied to cosmetics. Therefore, the key point of the compound preservative with good preservative and bacteriostatic effects is that the amino acid derivative containing the caprylyl amino acid derivative and/or the lauroyl amino acid derivative is compounded with the 1, 2-vicinal diol and the solvent.
Further, the compound preservative containing the amino acid derivative comprises the following components in percentage by weight:
0 to 40% of caprylyl amino acid derivative, for example, 0, 0.02%, 0.03%, 0.05%, 0.1%, 0.2%, 0.3%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 2%, 2.5%, 3%, 3.4%, 3.8%, 4%, 4.2%, 4.5%, 5%, 5.5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 20%, 22%, 25%, 30%, 35%, 38%, 39%, or 40% or the like;
0 to 40% of lauroyl amino acid derivative, for example, 0, 0.02%, 0.03%, 0.05%, 0.1%, 0.2%, 0.3%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 2%, 2.5%, 3%, 3.4%, 3.8%, 4%, 4.2%, 4.5%, 5%, 5.5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 20%, 22%, 25%, 30%, 35%, 38%, 39%, or 40%, etc.;
1 to 30% of 1, 2-vicinal diol, for example, 1%, 1.2%, 1.5%, 2%, 2.5%, 3%, 3.4%, 3.8%, 4%, 4.2%, 4.5%, 5%, 5.5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, or 30%;
the balance of solvent.
Wherein the compound preservative containing the amino acid derivative comprises the following components in percentage by weight, and the sum of the percentages is 100%.
Further, the compound preservative containing the amino acid derivative further comprises 0-10% of a neutralizing agent by weight percentage, such as 0, 0.02%, 0.03%, 0.05%, 0.1%, 0.2%, 0.3%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 2%, 2.5%, 3%, 3.4%, 3.8%, 4%, 4.2%, 4.5%, 5%, 5.5%, 6%, 7%, 8%, 9%, or 10%. When the other components except the neutralizing agent are in a non-transparent liquid state after being mixed, the neutralizing agent is added to enable the components to be quickly dissolved into a transparent liquid state, so that the quality of the compound preservative containing the amino acid derivative is improved.
Preferably, the neutralizing agent is selected from any one of sodium hydroxide, potassium hydroxide, triethanolamine or aminomethyl propanol. Wherein, any one of sodium hydroxide, potassium hydroxide, triethanolamine or aminomethyl propanol can be subjected to neutralization reaction with water-insoluble compound components such as caprylyl glycine in the compound preservative, so that the compound components are converted from a molecular state into a water-soluble ionic state, and the whole mixed solution is transparent.
Further, the 1, 2-vicinal diol is selected from any one or a mixture of at least two of pentanediol, hexanediol, octanediol and ethylhexyl glycerol. The amino acid derivative is added to the 1, 2-vicinal diol which is composed of pentanediol, hexanediol, octanediol and ethylhexylglycerin, wherein one or a mixture of at least two of the pentanediol, the hexanediol, the octanediol and the ethylhexylglycerin can be used as a preservative synergist, so that the preservative and bacteriostatic effects of an octanoyl chain and a lauroyl chain in the amino acid derivative can be effectively improved.
Further, the caprylyl amino acid derivative is selected from any one of caprylyl glycine, caprylyl lysine, bis-octylaminoethylglycine, N-octyl-diaminoethylglycine hydrochloride, and caprylyl glutamic acid or a mixture of at least two of the same.
Wherein, the di-octyl aminoethyl glycine has broad-spectrum antibacterial function and has excellent antibacterial capacity on gram-negative bacteria, positive bacteria, mould and microzyme. In addition, the di-octyl aminoethyl glycine has the property of an amphoteric surfactant, so that the foaming and cleaning performances are good, and the compatibility with other surfactants and high molecular auxiliary materials is good. When the di-octyl aminoethyl glycine is used as the amino acid derivative of the compound preservative, the prepared compound preservative has the following characteristics: (1) the bactericidal composition has broad-spectrum bactericidal capability and strong bactericidal capability on gram-negative bacteria, gram-positive bacteria, mould and yeast; (2) the bactericidal capacity is less influenced by the change of pH, and the product can adapt to a wider acid-base range; (3) the bactericidal activity is still strong in the presence of organic matters such as serum and protein; (4) the product is easy to be compatible with other surfactants and macromolecular thickeners; (5) has good cleaning ability, wetting ability and foamability and good thermal stability; (6) good solubility, no precipitate at low temperature; (7) no allergy and irritation to skin; (8) has high use safety and is a nontoxic substance.
The caprylyl glycine is used as an effective component of the cosmetics, can be used as a conditioner, a cleaning agent and the like in the compound preservative, can ensure that the cosmetics added with the compound preservative have good affinity to skin in the use process, can take effect efficiently, and can also convey other components efficiently, thereby improving the use effect of other effective products. In addition, the capryloyl glycine serving as an amino acid derivative can have a good antibacterial effect after being compounded with other components, has a strong inhibiting effect on staphylococcus aureus, propionibacterium acnes and the like, can resist excessive sebum secretion, and has a relatively obvious effect on preventing and treating acnes. When the compound preservative containing caprylyl glycine is used as a preservative in cosmetics without adding any preservative, the activation of elastase can be effectively inhibited, the decomposition of elastin is prevented, skin wrinkles are reduced, and the self-repairing function of skin can be adjusted.
The caprylyl glutamic acid has good cleaning and deodorizing effects, brings moistening and softening effects to skin and hair, and can be used safely. In addition, the caprylyl glutamic acid also has the effect of complexing metal ions, can limit the growth of mould in the environment with limited metal ions, and has strong bacteriostatic action because the carbon chain length can promote the degradation of a cell membrane structure.
Further, the lauroyl amino acid derivative is selected from any one of lauryl aminopropyl glycine, lauryl diethylene diamino glycine, sodium lauryl imino dipropionate, lauryl amino propionic acid, lauroyl lysine, and lauramine dipropylene diamine or a mixture of at least two of the same.
Among them, lauroyl lysine is used as a skin conditioner and a hair conditioner in cosmetics, and has a smooth skin feeling, antistatic property, and antioxidant property. Bacteriostatic tests show that the raw material has a strong inhibition effect on common mould such as aspergillus niger, candida albicans, trichoderma viride and the like, and also has a strong inhibition effect on staphylococcus aureus, bacillus subtilis, streptococcus pneumoniae and the like. Is a potential novel preservative substitute.
In recent years, the di-octyl aminoethyl glycine is widely used for disinfection and sterilization in places such as hospitals, animal husbandry, swimming pools, food and beverage processing industry and the like, is safe and non-irritant, is very mild to skin, and has wide market prospect.
Wherein, the lauryliminodipropionic acid is used as an antistatic agent, a cleaning agent and a foam booster in cosmetics. According to bacteriostasis tests, the lauryliminodipropionic acid has a strong inhibition effect on common mold such as aspergillus niger, pili, malus baccata, trichoderma viride and the like, has a strong inhibition effect on staphylococcus aureus, burkholderia cepacia and other bacteria, and is a potential novel preservative substitute.
Further, the solvent is selected from any one of water, propylene glycol and butanediol or a mixture of at least two of the water, the propylene glycol and the butanediol.
On the other hand, the preparation method of the compound preservative containing the amino acid derivative is provided, the amino acid derivative and the 1, 2-vicinal diol are dissolved in the solvent, then the neutralizing agent is selectively added, and the compound preservative in a transparent liquid state is prepared after dissolution.
After the amino acid derivative and the 1, 2-vicinal diol are dissolved in the solvent, an octyl chain and a lauryl chain in the prepared compound preservative can be rapidly combined with a microbial cell structure to interfere and inhibit the physiological environment of a cell membrane and effectively inhibit the growth of microorganisms.
Further, the preparation method comprises the following steps:
s10, weighing 0-40% of caprylyl amino acid derivative, 0-40% of lauroyl amino acid derivative, 1-30% of 1, 2-vicinal diol, 0-10% of neutralizing agent and the balance of solvent in percentage by weight, and uniformly stirring the caprylyl amino acid derivative, the lauroyl amino acid derivative, the 1, 2-vicinal diol and the solvent at 50-70 ℃ to prepare a mixture;
s20, selectively adding the neutralizer into the mixture, and completely dissolving the neutralizer into transparent liquid to obtain the compound preservative;
wherein the selective addition of neutralizing agent to the mixture is: when the mixture is a non-transparent liquid, the neutralizing agent needs to be added, otherwise the neutralizing agent does not need to be added.
Specifically, when the amino acid derivative contains caprylyl glycine, a neutralizing agent is added to neutralize the caprylyl glycine, so that the caprylyl glycine in a molecular state insoluble in water is converted into an ionic state soluble in water.
In another aspect, the invention also provides a cosmetic which comprises the compound preservative containing the amino acid derivative, and the cosmetic has good preservative and bacteriostatic effects and is safe and mild to use.
The invention has the beneficial effects that: octyl chains in the caprylyl amino acid derivatives and lauryl chains in the lauroyl amino acid derivatives can be combined with microbial cell structures to interfere with the physiological environment of the inhibited cell membranes, namely selectively gather on the water-oil interface in an oil-in-water emulsification system, so that the food sources of the microbes in the area are changed to be unfavorable for the growth of the microbes, thereby inhibiting the growth of the microbes; the 1, 2-vicinal diol can be used as an additive-free preservative, and can generate a synergistic effect after being compounded with the caprylyl amino acid derivative and the lauroyl amino acid derivative dissolved in a solvent, so that the preservative and bacteriostatic effects of an octyl chain in the caprylyl amino acid derivative and a lauryl chain in the lauroyl amino acid derivative can be improved, and the compound preservative has a good preservative and bacteriostatic effect and is very safe and mild to use.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments.
Unless otherwise specified, various starting materials of the present invention are commercially available or prepared according to conventional methods in the art.
Example 1
The compound preservative containing the glycine derivative in the embodiment is prepared by the following method:
step A, weighing the following components in percentage by weight:
bis-octylaminoethylglycine: 10 percent of
Capryloyl glycine: 3 percent of
Sodium hydroxide: 0.55 percent
Hexanediol: 30 percent of
Water: 56.45 percent;
b, stirring and mixing the di-octyl aminoethyl glycine, the caprylyl glycine, the hexanediol and the water at 50-70 ℃;
and step C, adding sodium hydroxide for neutralization, so that the raw materials are completely dissolved into transparent liquid.
Example 2
The compound preservative containing the glycine derivative in the embodiment is prepared by the following method:
step A, weighing the following components in percentage by weight:
bis-octylaminoethylglycine: 5 percent of
Lauroyl lysine: 5 percent of
Potassium hydroxide: 0.75 percent
And (3) pentanediol: 30 percent of
Butanediol: 10 percent of
Water: 49.25 percent;
b, stirring and mixing the di-octyl aminoethyl glycine, the lauroyl lysine, the potassium hydroxide, the pentanediol, the butanediol and the water at 50-70 ℃;
and step C, adding potassium hydroxide for neutralization, so that the raw materials are completely dissolved into transparent liquid.
Example 3
The compound preservative containing the glycine derivative in the embodiment is prepared by the following method:
step A, weighing the following components in percentage by weight:
bis-octylaminoethylglycine: 10 percent of
Lauryiminodipropionic acid: 2 percent of
Sodium hydroxide: 0.4 percent
Hexanediol: 30 percent of
Water: 57.6 percent;
b, stirring and mixing the di-octyl aminoethyl glycine, the lauryliminodipropionic acid, the hexanediol and the water at 50-70 ℃;
and step C, adding sodium hydroxide for neutralization, so that the raw materials are completely dissolved into transparent liquid.
And (3) verification test:
in this experiment, the compound preservative prepared in examples 1 to 3 was tested using mixed bacteria of escherichia coli, pseudomonas aeruginosa, and staphylococcus aureus, and mixed fungi of aspergillus niger and candida albicans.
Experiment 1 facial mask liquid
The ingredients of the mask solution are shown in table 1, the mask solution is divided into 7 equal parts, wherein the first part of the mask solution is the mask solution without any preservative, 0.5% of the compound preservative in example 1 is added into the second part of the mask solution and the third part of the mask solution respectively, 0.5% of the compound preservative in example 2 is added into the fourth part of the mask solution and the fifth part of the mask solution respectively, and 0.5% of the compound preservative in example 3 is added into the sixth part of the mask solution and the seventh part of the mask solution respectively. The following bacteria and molds were added to the samples to which the preservatives had been added: 1X 106cfu/g Staphylo coccus aureus ATCC 6538、1×106cfu/g Pseudomonas aeruginosaATCC 9027、1×106cfu/g Escherichia coli ATCC 8739、1×106cfu/g Canadida albicanaATCC 10231、1×106cfu/g Aspergillus nigre ATCC 16404. Placing in an incubator at 37 deg.CThe total number of colonies in each facial mask solution was measured after 7 days, 14 days and 28 days, respectively, and the results are shown in Table 2.
TABLE 1 composition of facial mask solutions
| Name (R) | Mass/g |
| Water (W) | 84.47 |
| EDTA2Na | 0.01 |
| Oat glucan | 1.00 |
| Fructose | 8.00 |
| Polyglutamic acid sodium salt | 1.00 |
| Hydroxyethyl cellulose | 0.03 |
| Carbomer 941 | 0.20 |
| TEA | 0.1 |
| Hyaluronic acid sodium salt | 0.10 |
| Chinese gum | 0.20 |
| Glycerol | 5.00 |
TABLE 2 comparative data for bacteria and mold in various facial mask solutions
Experiment 2 cream
The cream composition is shown in table 3, and the cream is divided into 7 equal parts, the first part is blank cream without preservative; the second and third creams were each supplemented with 0.5% of the formulated preservative of example 1, the fourth and fifth creams were each supplemented with 0.5% of the formulated preservative of example 2, and the sixth and seventh creams were each supplemented with 0.5% of the formulated preservative of example 3. The following bacteria and molds were added to the samples to which the preservatives had been added: 1X 106cfu/g Staphylo coccusaureus ATCC 6538、1×106cfu/g Pseudomonas aeruginosa ATCC 9027、1×106cfu/gEscherichia coli ATCC 8739、1×106cfu/g Canadida albicana ATCC 10231、1×106cfu/g Aspergillus nigre ATCC 16404. The culture boxes were placed at 37 ℃ for 7 days, 14 days and 28 days, and the total number of colonies was measured, respectively, and the results of the measurements are shown in Table 4.
TABLE 3 cream composition
| Name (R) | Mass/g |
| Cetostearyl alcohol | 1.50 |
| 15#White oil | 1.00 |
| Caprylic capric acid triglyceride | 5.00 |
| Myristic acid isopropyl ester | 3.00 |
| Jojoba oil | 4.00 |
| Brij 72 | 1.00 |
| Brij 721 | 1.50 |
| 1, 3-butanediol | 10.00 |
| Glycerol | 5.00 |
| Chinese gum | 0.10 |
| EDTA-2Na | 0.03 |
| Deionized water | 67.87 |
TABLE 4 comparison data of bacteria and mold for each cream
Tests show that the compound preservative has a good bacteriostatic effect, is very safe and mild, and is suitable for a cosmetic system with high formula mildness.
The above examples are only intended to illustrate the detailed process of the present invention, and the present invention is not limited to the above detailed process, i.e., it is not intended that the present invention necessarily depends on the above detailed process for its implementation. It is understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention and the addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. The compound preservative containing the amino acid derivative is characterized by comprising the amino acid derivative, 1, 2-vicinal diol and a solvent, wherein the amino acid derivative is an octanoyl amino acid derivative and/or a lauroyl amino acid derivative.
2. The compound preservative containing the amino acid derivative according to claim 1, which is characterized by comprising the following components in percentage by weight:
3. the compound preservative containing the amino acid derivative according to claim 2, characterized by further comprising 0-10% by weight of a neutralizing agent;
preferably, the neutralizing agent is selected from any one of sodium hydroxide, potassium hydroxide, triethanolamine or aminomethyl propanol.
4. The compound preservative containing the amino acid derivative as claimed in claim 1, wherein the 1, 2-vicinal diol is selected from any one or a mixture of at least two of pentanediol, hexanediol, octanediol, and ethylhexylglycerin.
5. The compound preservative containing the amino acid derivatives as claimed in claim 1, wherein the caprylyl amino acid derivatives are selected from any one or a mixture of at least two of caprylyl glycine, caprylyl lysine, bis-octyl aminoethyl glycine, N-octyl-diamino ethyl glycine hydrochloride and caprylyl glutamic acid.
6. The compound preservative containing the amino acid derivatives as claimed in claim 1, wherein the lauroyl amino acid derivatives are selected from any one or a mixture of at least two of lauryl aminopropyl glycine, lauryl diethylene diamino glycine, sodium lauryl imino dipropionate, lauryl amino propionic acid, lauroyl lysine and lauramine dipropylene diamine.
7. The compound preservative containing the amino acid derivative as claimed in claim 1, wherein the solvent is selected from any one of water, propylene glycol and butylene glycol or a mixture of at least two of the water, the propylene glycol and the butylene glycol.
8. The method for preparing the compound preservative containing the amino acid derivative as claimed in any one of claims 1 to 7, wherein the amino acid derivative and the 1, 2-vicinal diol are dissolved in the solvent, and then a neutralizing agent is selectively added to dissolve the amino acid derivative and the 1, 2-vicinal diol to obtain the compound preservative in a transparent liquid state.
9. The method of claim 8, comprising the steps of:
s10, weighing 0-40% of caprylyl amino acid derivative, 0-40% of lauroyl amino acid derivative, 1-30% of 1, 2-vicinal diol, 0-10% of neutralizing agent and the balance of solvent in percentage by weight, and uniformly stirring the caprylyl amino acid derivative, the lauroyl amino acid derivative, the 1, 2-vicinal diol and the solvent at 50-70 ℃ to prepare a mixture;
s20, selectively adding the neutralizer into the mixture, and completely dissolving the neutralizer into transparent liquid to obtain the compound preservative;
wherein the selective addition of neutralizing agent to the mixture is: when the mixture is a non-transparent liquid, the neutralizing agent needs to be added, otherwise the neutralizing agent does not need to be added.
10. A cosmetic comprising the compound preservative containing an amino acid derivative according to any one of claims 1 to 7.
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| CN109528523A (en) * | 2018-12-28 | 2019-03-29 | 广州蔻赛生物科技有限公司 | A kind of amino acid cleansing cream |
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| CN110279603A (en) * | 2019-07-16 | 2019-09-27 | 伊乐生物科技（广州）有限公司 | A kind of Compositional antiseptic agent and preparation method for cosmetics |
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| CN107821398A (en) * | 2017-10-18 | 2018-03-23 | 福建恒安集团有限公司 | A kind of water-soluble amino acids Compositional antiseptic agent |
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| CN109528523A (en) * | 2018-12-28 | 2019-03-29 | 广州蔻赛生物科技有限公司 | A kind of amino acid cleansing cream |
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Application publication date: 20200512 |