KR20090001268A - Cosmetic composition comprising thyme oil for treating acne vulgaris - Google Patents

Abstract

A cosmetic composition for treating pimple is provided to reduce side effect and to improve the antibacterial effect to Propionibacterium acnes by using a thyme oil. A cosmetic composition for treating pimple comprises a thyme oil in an effective amount; and an already-known cosmetic composition. Preferably the content of a thyme oil is 0.005-20 wt% based on the total weight of the cosmetic composition.

Description

Cosmetic composition for treating acne including thyme oil {Cosmetic composition comprising thyme oil for treating acne vulgaris}

Figure 1 is a graph showing the results of quantitative analysis of thyme oil (Thyme oil) shown by gas chromatography (Gas Chromatography) measurement method.

Figure 2 shows the results of antimicrobial activity against propionibacterium acne of thyme oil (Thyme oil) shown by viable cell count method.

The present invention relates to a composition for skin containing a natural fragrance that is effective against acne, and more particularly to a natural fragrance having antibacterial activity against propionibacterium acnes, which is a major cause of skin diseases such as acne. The present invention relates to a cosmetic composition for treating and preventing acne diseases containing thyme oil as an active ingredient.

Acne is an inflammatory disease of the fur branch and is one of the most common skin diseases that cause inflammation of the facial skin hair follicles. The causes include hormones, excess serum and bacteria. Of these, acne rashes caused by bacteria are typically caused by propionibacterium acnes called acne. Propionibacterium acne produces lipolytic enzymes to digest excess oils and serum in the skin. Antigen reactions between fatty acids and bacteria, which are digested by it, promote inflammation in the skin, which leads to acne. Bring. In order to prevent skin damage caused by acne, synthetic antibacterial substance such as erythromycin, which has excellent antibacterial activity against propionibacterium acne, is used, but physical side effects such as gastrointestinal disorder, liver and kidney damage, etc. In addition, it is pointed out that it only increases the immunity of antibacterial agents of the flora.

In addition, to treat acne, it may be applied chemically with vitamin A derivatives, azelaic acid, triclosan, or a coating agent of benzolperoxide, which may cause skin irritation. There is this. Although bactericidal treatments are used, antimicrobial agents such as Tetracycline have caused many problems such as causing resistant bacteria and causing side effects such as photosensitivity (Webster GF, Acne vulgaris. J Am Acad Derm 1995 (33)). pp247-253).

Therefore, there is a need for hypoallergenic cosmetic compositions developed from natural-derived raw materials that do not cause skin irritation and cause side effects other than chemical raw materials.

Thus, the present inventors have found that the thyme oil (Thyme oil) has an excellent effect as a result of measuring the antibacterial effect and acne-producing function against the acne bacteria in the natural flavor to solve the above problems.

An object of the present invention is to be effective in the prevention and treatment of acne by having an excellent antibacterial effect and the reduction of cotton cloth on the acne bacterium Propionibacterium acnes, while improving the disadvantages and side effects of conventional acne treatments It is an object to provide a cosmetic composition that can be.

The cosmetic composition for acne treatment containing the thyme oil which concerns on this invention mixes the effective amount of thyme oil with a well-known cosmetic composition.

The effective amount of the thyme oil may be within 0.05 to 20% by weight, preferably 2 to 10% by weight based on the total weight of the known cosmetic composition.

The known cosmetic composition may be selected from the group consisting of lotion, lotion, essence, nourishing cream, concealer, pack, massage cream, cleansing foam, patches.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

The present invention provides a cosmetic composition containing thyme oil in an amount effective for treating and improving acne. The effective amount of the thyme (Thyme oil) is preferably 0.05 to 20% by weight based on the total weight of the cosmetic, the most preferred content is 2 to 10% by weight in terms of stability of the cosmetic formulation and efficacy against acne bacteria. The cosmetics containing the thyme oil (Thyme oil) is used in the form of lotion, lotion, essence, nourishing cream, concealer, pack, massage cream, cleansing foam, patch, the base properties are liquid, solid, cream Any of a paste form is possible.

Thyme oil used in the present invention is a horse derived from the Greek word 'disinfect' and contains a strong bactericidal component called thymol, which has been used as an antiseptic agent since ancient times. The ancient Egyptians used it as a preservative of the carcass, and in the late Middle Ages, because of the strong disinfection of the plant, the judges reportedly brought small stems of thyme to court to prevent infection (The Directory of Essential Oils, pp 229-231.1996).

Thyme oil (Thyme oil) used in the present invention showed an excellent antimicrobial activity against acne bacteria and even when applied to the cosmetic composition it showed an antibacterial effect regardless of the physical properties.

The thyme oil can be used to obtain an essential oil of 1.58 to 14.9% by steaming and distilling the herb in the flowering of Timus vulgaris, and to obtain 2.6% of essential oil from hay, or solvent extraction to make an anhydrous essential oil. .

Hereinafter, preferred embodiments and comparative examples of the present invention will be described.

The following examples are intended to illustrate the invention and should not be understood as limiting the scope of the invention.

Example  One

Evaluation of Antimicrobial Activity against Thyme Oil against Acne Bacteria (Propionibacterium acnes)

Propionibacterium Acne (KCTC 4314) received from the Korea Microbial Conservation Center was activated by incubation in anaerobic conditions at 37 ° C. for 72 hours in Reinforced Clostridial Medium (hereinafter referred to as 'RCM'). With this culture, a paper disc method was performed. At this time, the bacterial count of propionibacterium acne, an acne-causing strain in the activated culture, was 2x10 ⁹ cfu / ml as measured by the viable cell count method. In the experiment, 1.5% agar was added to the RCM, and then the flow plate method was used. After incubating the strains for 3 days under the same conditions, 100 μl of each petri dish was smeared, and the thyme oil was diluted to 1.0%, 0.5%, and 0.1% using dimethyl sulfoxide (DMSO). After incubation at 60 μl in paper discs for 72 hours under the same conditions, the presence or absence of clear zones was observed. As a result, as shown in Figure 2, forming a transparent region at each concentration, showed an effective result, as a result it was confirmed that the thyme oil has a very high antibacterial activity.

Therefore, in order to more accurately measure the antimicrobial activity concentration of propionibacterium acne, the acne causative strain of thyme oil, the minimum inhibitory concentration (MIC) of acne causative strain (P.acnes) was measured. After dispensing acne causative strain (P.acnes, 2x109 cfu / ml) cultured in 9ml of sterilized RCM to 1ml, the final concentration of thyme oil can be 1%, 0.5%, 0.1%, 0.05%, 0.01%. After diluting each, incubation for 72 hours under the same conditions to confirm the suspension, in order to confirm the growth of the correct strain, each experimental section was smeared 100 μl on RCM plate agar and cultured for 72 hours under the same conditions. After that, the growth of acne causing strain (P.acnes) was confirmed.

After cultivation, the presence of acne causative strain growth of petri dish was not shown in Table 1, the acne causative strain (P.acnes) did not grow in the experimental group containing more than 0.05% of thyme oil, the growth of the bacteria in 0.01% And it was found. Accordingly, the minimum inhibitory concentration of thyme oil against acne causative strain (P.acnes) was 0.05%. In addition, similar results were found for various strains that were present in human resources and could cause skin problems.Thus, thyme oil (Thyme Oil) Cosmetic formulations containing) were prepared and tested.

Sample concentration One% 0.5% 0.1% 0.05% 0.01% Thyme oil-containing medium - - - - *  *: Propionibacterium acne growth possible concentration-: Propionibacterium acne growth impossible concentration

Below is an example of a cosmetic composition that contains thyme oil in each cosmetic formulation to prevent the damage to the skin by inhibiting the growth of various strains that can cause acne and skin problems. An example follows.

Table 2 below shows the composition of the lotion preparation containing thyme oil.

ingredient Content (% by weight) Thyme Oil (Thyme) 2.0 1,3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 POE (20) sorbitan monolauric acid ester 0.5 POE (15) lauryl alcohol ether 0.5 ethanol 10.0 Triethanolamine 0.1 Ethylenediaminetetraacetate 0.1 antiseptic 0.1 Purified water Remaining amount  POE; Polyoxyethylene (carbon number)

Table 3 below shows the composition of the lotion formulation containing thyme oil.

ingredient Content (% by weight) Thyme Oil (Thyme) 2.0 Dipropylene glycol 6.0 glycerin 4.0 Sorbitan stearate sucrose cocoate 2.0 Mineral oil 4.0 Trioctanoine 1.0 Stearic acid 1.0 Glyceryl Stearate 0.5 Sorbitan monostearate 2.0 Dimethicone 0.6 Antioxidant 0.3 Carbomer 0.1 Triethanolamine 0.1 Ethylenediaminetetraacetate 0.1 antiseptic 0.1 Purified water Remaining amount

Table 4 below shows the composition of the essence formulation containing thyme oil.

ingredient Content (% by weight) Thyme Oil (Thyme) 2.0 Sorbitol 8.0 1,3-butylene glycol 5.0 PEG 1500 7.0 Hyaluronic acid 0.1 Carbomer 1.0 Glycine 3.0 Polyacrylamide 2.0 Hydroxyethyl Cellulose 0.2 ethanol 7.0 POE oleyl alcohol ether 1.0 Antioxidant 0.3 Triethanolamine 0.1 Ethylenediaminetetraacetate 0.1 antiseptic 0.1 Purified water Remaining amount

Table 5 below shows the composition of the nourishing cream formulation containing thyme oil.

ingredient Content (% by weight) Thyme Oil (Thyme) 2.0 Dipropylene glycol 3.0 glycerin 3.0 Hydrogenated Lecithin 1.0 Trioctanoine 3.0 Trioctanoine 2.0 Stearic acid 2.0 Sorbitan sesquioleate 2.0 Dimethicone 3.0 Cetostearyl alcohol 1.5 Polysorbate 60 1.5 Antioxidant 0.3 Xanthan Gum 0.2 Triethanolamine 0.1 Ethylenediaminetetraacetate 0.1 antiseptic 0.1 Purified water Remaining amount

Table 6 below shows the composition of the concealer (stick type) formulation containing thyme oil.

ingredient Content (% by weight) Thyme Oil (Thyme) 2.0 kaoline 20.0 Titanium dioxide 17.5 Talc 2.8 Mica 3.0 Iron sulfate 3.0 Black iron oxide 0.2 Bengara 1.0 Solid paraffin 3.0 Microcrystalline Wax 7.0 Vaseline 15.0 Dimethyl Polysiloxane 3.0 Squalane 5.0 Isopropyl Palmitate 17.0 Antioxidant 0.5

Table 7 below shows the composition of the pack formulation containing thyme oil.

ingredient Content (% by weight) Thyme Oil (Thyme) 2.0 PEG1500 3.0 Sorbitol 3.0 glycerin 4.0 Squalene 3.0 Dimethicone 2.0 Glycine 2.0 Sodium hyaluronate 0.1 Polyacrylamide 4.0 Antioxidant 0.3 Carboxy Vinyl Polymer 5.0 Xanthan Gum 1.0 Triethanolamine 0.1 Ethylenediaminetetraacetate 0.1 antiseptic 0.1 Purified water Remaining amount

Table 8 below shows the composition of a massage cream formulation containing thyme oil.

ingredient Content (% by weight) Thyme Oil (Thyme) 2.0 Microcrystalline Wax 9.0 Solid paraffin 3.0 Beeswax 3.0 Vaseline 5.0 Reduced lanolin 4.0 Hexadecyl Adipic Acid Ester 10.0 Squalane 34.0 Propylene glycol 5.0 Glycerin Monooleate 3.5 POE (20) sorbitan monooleic acid ester 1.0 antiseptic 0.1 Antioxidant 0.05 Purified water Remaining amount

Table 9 below shows the composition of the cleansing foam formulation containing thyme oil.

ingredient Content (% by weight) Thyme Oil (Thyme) 2.0 Myristic acid 14.0 Stearic acid 12.0 Lauric acid 5.0 Potassium hydroxide 5.0 Jojoba You 3.0 Solbite (Sorbitol 70% Soln) 15.0 1,3-butylene glycol 10.0 glycerin 10.0 Acylmethyltaurine 4.0 POE (20) Glycerol Monostearic Acid Ester 2.0 Ethylenediaminetetraacetate 0.1 Purified water Remaining amount

Table 10 below shows the composition of the patch formulation containing thyme oil.

ingredient Content (% by weight) Thyme Oil (Thyme) 5.0 1,3-butylene glycol 6.0 glycerin 4.0 ethanol 10.0 Triethanolamine 0.1 Ethylenediaminetetraacetate 0.1 antiseptic 0.1 Purified water Remaining amount

Therefore, according to the present invention for treating and preventing acne diseases containing a natural fragrance thyme oil (Thyme oil) having an antimicrobial activity against propionibacterium acnes, the main cause of acne and other skin diseases It is effective in providing a cosmetic composition.

Although the present invention has been described in detail only with respect to the described embodiments, it will be apparent to those skilled in the art that various modifications and variations are possible within the technical scope of the present invention, and such modifications and modifications are within the scope of the appended claims.

Claims (4)

Cosmetic composition for treating acne comprising thyme oil, characterized in that the effective amount of thyme oil is mixed with a known cosmetic composition. The method of claim 1, Cosmetic composition for treating acne comprising thyme oil, characterized in that the effective amount of the thyme oil is within 0.005 to 20% by weight based on the total weight of the known cosmetic composition. The method of claim 2, Cosmetic composition for treating acne comprising thyme oil, characterized in that the effective amount of the thyme oil is within 2 to 10% by weight based on the total weight of the known cosmetic composition. The method according to any one of claims 1 to 3, The cosmetic composition for acne treatment comprising a thyme oil, characterized in that the known cosmetic composition is selected from the group consisting of lotion, lotion, essence, nutrition cream, concealer, pack, massage cream, cleansing foam, patches.

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