KR20100089698A - A cosmetic composition - Google Patents

Abstract

PURPOSE: A cosmetic composition containing hexylene glycol is provided to prevent denaturation and ensure moisturization without irritation. CONSTITUTION: A cosmetic composition contains 0.1-10 weight parts of hexylene glycol of chemical formula 1 based on 100 weight part. The addition of hexylene glycol improves antibacterial activity of the cosmetic composition. The composition further contains 0.1-10 weight parts of ethylhexyl glycerin of chemical formula 2. The athylhexyl glycerin enhances antibacterial function and moisturization. The cosmetic composition is used in the form of lotion, cream, pack, cleansing, or essence.

Description

A cosmetic composition

The present invention relates to a cosmetic composition, and more particularly to a cosmetic composition having an excellent antimicrobial activity and adding a substitute of artificial preservatives that prevents the deterioration of the cosmetic composition, without the use of preservatives or fungicides. In addition, it relates to a cosmetic composition that not only has excellent antimicrobial activity but also has no irritation to the skin and improves moisturizing ability.

In order to keep skin clean and healthy, cosmetics are formulated with moisturizers and nutrients such as glycerin, sorbitol, amino acid derivatives and sodium hyaluronate. The components blended in the cosmetics are a carbon source or nitrogen source of the microorganisms, and the cosmetics are in a state suitable for growth of the microorganisms. In addition, cosmetics are easily infiltrated by microorganisms such as bacteria, molds, and bacteria, and are easily contaminated through fingers or the like during use. Therefore, fungicides or preservatives are added for long-term storage of cosmetics from malodor, decay, chemical changes, and the like.

Some of the materials used as preservatives for cosmetics are natural ones, but most of them are chemically synthesized artificial substances. Examples of preservatives include inexpensive parabens artificially synthesized, imidazolidinyl urea, diazolidinyl urea, phenoxyethanol and the like. However, the antiseptic and preservatives are formulated into cosmetics to prevent deterioration caused by various bacteria, molds, bacteria and the like, and to maintain them stably, and may also cause skin troubles such as porgy and itching. Even the parabens preservatives, which are known to be the safest among the existing preservatives, are widely used in cosmetics and medicines (Andrea Counti Etal., Contact Dermatitis, 1997, 37; 35-36), the potential as environmental hormones ( Edwin et al., Toxicology and applied pharmacology, 1998, 153; 12-19), and resistant bacteria.

As described above, due to the risk of such artificial preservatives, many companies feel the need for artificial preservative substitutes, but they are not commercialized due to the high cost and the lack of technology. Recently, a product using a natural extract having an antiseptic effect has been developed. However, in the case of natural active substances, commercialization is particularly difficult due to color odor, deterioration of stability, narrow antibacterial spectrum, and formulation problems. Only a few parts, such as hinokitiol (nanobaek extract), magnolol (magnolol) and grapefruit extract (DF-100) are commercially available.

In addition, when developing an artificial preservative substitute, there is a difficulty in selecting a raw material in consideration of preservative performance and safety of skin irritation.

Therefore, there is a need for the development of an antiseptic composition which reduces the side effects of the existing artificial synthetic preservatives and at the same time has a broad antibacterial spectrum, formulation stability and the like.

An object of the present invention to solve the above problems is excellent cosmetics, and has a broad antibacterial spectrum, so that the cosmetic composition containing a substitute for artificial preservatives that do not need to use a separate preservative because it can be stored for a long time when formulated in cosmetics To provide a composition. In addition, to provide a cosmetic composition that not only has excellent antimicrobial activity but also has no irritation and safety on the skin, and improves moisturizing ability.

The present invention to achieve the above object,

It provides a cosmetic composition comprising 0.1 to 10 parts by weight of hexylene glycol based on a total of 100 parts by weight of the cosmetic composition.

The cosmetic composition may further include 0.1 to 10 parts by weight of ethylhexylglycerin based on 100 parts by weight of the total cosmetic composition.

The cosmetic composition may be a formulation selected from the group consisting of lotion, lotion, cream, pack, cleansing and essence.

The cosmetic composition of the present invention is excellent in antibacterial effect, the antimicrobial spectrum is wide, preventing contamination by microorganisms. In addition, there is no need to add artificial preservatives or fungicides to cosmetics because it does not deteriorate well and can be stored for a long time.

The cosmetic composition of the present invention is excellent in skin safety, there is no irritation on the skin, and does not cause skin allergy, troubles, etc., and thus it can be used for various skin types.

Not only antibacterial and skin safety, but also moisturizing.

In addition, the cosmetic composition of the present invention can be formulated into a variety of formulations, such as creams, lotions, essences, the formulation is stable.

Hereinafter, the present invention will be described in detail so that those skilled in the art can easily implement the present invention.

Cosmetic composition of the present invention comprises hexylene glycol (hexylene glycol). In addition, the cosmetic composition may further include ethylhexyl glycerin (ethylhexyl glycerin). The cosmetic composition has an antibacterial effect on pathogens, molds, yeast, etc., including E. coli, the antimicrobial spectrum is broad, and the antimicrobial activity is excellent and does not deteriorate due to microbial contamination and maintains purity during use. In addition, the skin is less irritating and improves moisturizing power. Typically, the cosmetic composition is added to the disinfectant and preservatives for long-term preservation of cosmetics, the cosmetic composition of the present invention has excellent antimicrobial power and is safe for the skin, so the cosmetic composition of the present invention is a artificial artificial preservative or There is no need to add fungicides.

The hexylene glycol is represented by the following Chemical Formula 1:

The hexylene glycol is excellent in the antibacterial effect and prevents the deterioration of the cosmetic and increases the moisturizing power of the cosmetic.

The hexylene glycol may be included in an amount of 0.1 to 10 parts by weight based on 100 parts by weight of the total cosmetic composition. If less than 0.1 part by weight, the antimicrobial activity is insignificant, and when added in excess of 10 parts by weight, the antibacterial activity synergistic effect is insignificant compared to the added amount, irritating the skin and unstable cosmetic emulsion phase.

The ethylhexyl glycerin is represented by the following Formula 1:

When the ethylhexyl glycerin is used in combination with the hexylene glycol, the antibacterial and moisturizing properties are increased. In addition, the ethylhexyl glycerin is less irritating to the skin and does not cause allergies or skin problems. The ethylhexyl glycerin has excellent skin moisturizing effect and provides nutrition to the skin, so it is widely used in skin conditioning products and also has a deodorizing effect.

The ethylhexyl glycerine may be included in 0.1 to 10 parts by weight based on 100 parts by weight of the total cosmetic composition. When included in less than 0.1 part by weight, the antimicrobial activity for achieving the object of the present invention is insignificant, and when added in excess of 10 parts by weight, the effect of increasing the antimicrobial activity, moisturizing power is insignificant compared to the added amount and the cosmetic emulsion is unstable and inefficient.

The cosmetic composition may be formulated in various ways. Preferably it may be a formulation selected from the group consisting of lotion, lotion, cream, pack, cleansing and essence. Extensive formulations include Skin Lotion, Skin Softener, Skin Toner, Astringent, Lotion, Milk Lotion, Moisturizing Lotion, Nutrition Lotion, Massage Cream, Nutrition Cream, Moisture Cream, Hand Cream, Essence, Nutrition Essence, Pack, Cleansing Foam, Cleansing Lotion, cleansing cream, body lotion, press powder, loose powder, eye shadow and the like.

To the cosmetic composition, as a known component generally used in cosmetics, surfactants, ultraviolet absorbers, moisturizers, fragrances, salts, antioxidants, skin care ingredients, oils and vitamins can be added, the effects of the present invention It can mix suitably in the range which does not impair.

The cosmetic composition of the present invention may be included in bath articles, soaps, external pharmaceutical preparations, pack products and the like. The external preparation for medicines may be formulated as a solution, suspension, spray, patch, pad, cream, ointment, gel and the like.

Hereinafter, the present invention will be described in more detail with reference to Examples. The following examples are only intended to explain the present invention more easily, but the scope of the present invention is not limited thereto.

<Examples 1 to 7 and Comparative Examples 1 to 4> Preparation of the cream of the O / W type

To prepare a cream of the O / W type according to a known method known in the art in the composition of Table 1. In addition, the cream of the comparative example was manufactured by the composition of Table 2 in the same method as the cream manufacturing method of the Example. The units in Tables 1 and 2 below are parts by weight.

ingredient Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Mineral oil 25.0 25.0 25.0 25.0 25.0 25.0 25.0 Isopropyl Palmitate 10.0 10.0 10.0 10.0 10.0 10.0 10.0 Cetyl alcohol 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Stearic acid 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Vaseline 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Tocopheryl acetate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Spices A reasonable amount A reasonable amount A reasonable amount A reasonable amount A reasonable amount A reasonable amount A reasonable amount Polysorbate 60 2.5 2.5 2.5 2.5 2.5 2.5 2.5 Sorbitan monostearate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Glyceryl Monostearate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Sodium Ethylenediaminetetraacetic Acid 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Methyl paraben - - - - - - - Phenoxyethanol - - - - - - - Propylparaben - - - - - - - Hexylene glycol 2.0 0.1 10.0 2.0 5.0 5.0 5.0 Ethylhexylglycerin - - - 0.5 0.1 5.0 10.0 Purified water Balance Balance Balance Balance Balance Balance Balance

ingredient Comparative Example 1 Comparative Example 2 Comparative example
3 Comparative example
4 Mineral oil 25.0 25.0 25.0 25.0 Isopropyl Palmitate 10.0 10.0 10.0 10.0 Cetyl alcohol 0.22 0.22 0.22 0.22 Stearic acid 3.0 3.0 3.0 3.0 Vaseline 3.0 3.0 3.0 3.0 Tocopheryl acetate 0.2 0.2 0.2 0.2 Spices A reasonable amount A reasonable amount A reasonable amount A reasonable amount Polysorbate 60 2.5 2.5 2.5 2.5 Sorbitan monostearate 1.0 1.0 1.0 1.0 Glyceryl Monostearate 0.5 0.5 0.5 0.5 Butylene glycol 5.0 5.0 5.0 5.0 Sodium Ethylenediaminetetraacetic Acid 0.05 0.05 0.05 0.05 Methyl paraben 0.15 - - - Phenoxyethanol 0.2 - - - Propylparaben 0.02 - - - Pentylene glycol - - 5.0 5.0 Caprylyl Glycol - - - 0.5 Hexylene glycol - - - - Ethylhexylglycerin - 10 - - Purified water Balance Balance Balance Balance

<Example 8, 9 and Comparative Example 5> Preparation of O / W type lotion

To the lotion of the O / W type by a method known in the art in the composition of Table 3 below.

ingredient Example 8 Example 9 Comparative Example 5 Mineral oil 10.0 10.0 10.0 Isopropyl Palmitate 5.0 5.0 5.0 Cetyl alcohol 0.5 0.5 0.5 Stearic acid 1.0 1.0 1.0 Vaseline 1.0 1.0 1.0 Tocopheryl acetate 0.2 0.2 0.2 Spices A reasonable amount A reasonable amount A reasonable amount Polysorbate 60 2.0 2.0 2.0 Sorbitan monostearate 1.0 1.0 1.0 Glyceryl Monostearate 0.5 0.5 0.5 Butylene glycol 5.0 5.0 5.0 Sodium Ethylenediaminetetraacetic Acid 0.05 0.05 0.05 Methyl paraben - - 0.15 Phenoxyethanol - - 0.2 Propylparaben - - - Hexylene glycol 1.5 1.5 - Ethylhexylglycerin - 0.4 - Purified water Balance Balance Balance

<Example 10,11 and Comparative Example 6> Preparation of skin lotion of the lotion type

To a skin lotion of the lotion type by a method known in the art in the composition of Table 4 below.

Example 10 Example 11 Comparative Example 6 ethanol 7.0 7.0 7.0 Propylene glycol 5.0 5.0 5.0 Butylene Glycol 3.0 3.0 3.0 Polysorbate 20 2.0 2.0 2.0 Pigment A reasonable amount A reasonable amount A reasonable amount Spices A reasonable amount A reasonable amount A reasonable amount Methyl paraben - - 0.15 Phenoxyethanol - - 0.2 Propylparaben - - - Hexylene glycol 2.0 2.0 - Ethylhexylglycerin - 0.5 - Purified water Balance Balance Balance

Experimental Example 1 Measurement of Minimum Inhibitory Concentration (MIC)

Escherichia Coli (ATCC 9637), Candida albicans (ATCC 22019) and Propionibacterium Acnes (ATCC 1916) were used as experimental strains. First, the experimental strains were BHI liquid medium containing Tryptic Soy Broth (Difco. USA) and abouraud Dextrose Broth (Difco. USA), Tryptic Soy Agar (Difco. USA), abouraud Dextrose Agar (Difco. USA) and Micro, respectively. Agar (DUCHEFA BIOCHEMID, Netherlands) was incubated for 24 hours under 37 ° C., anaerobic (85% N ₂ , 10% CO ₂ , 5% H ₂ ) in BHI agar medium. 10 μl of 100-fold dilutions of the cultured strains were inoculated in BHI liquid medium. Ethylhexyl glycerin and hexylene glycol were added to the BHI liquid medium, respectively, in order to determine the minimum inhibitory concentration (MIC) of each of the hexyl glycerin and hexylene glycol for each experimental strain. The BHI liquid medium to which the experimental strain, ethylhexyl glycerin and hexylene glycol were added, was subjected to CO ₂ at 37 ° C. After 24 hours of incubation in an incubator (80% N ₂ , 10% CO ₂ , 10% H ₂ ), the absorbance was measured at 600 nm. The concentrations of each of the hexahexyl glycerine and hexylene glycol added to the experimental strain culture medium having absorbance measured at 0.050 or less were determined by MIC for the experimental strain. The results are shown in Table 5 below.

division Ethylhexyl glycerin (% by weight) Hexylene glycol (% by weight) Escherichia Coli (ATCC 9637) 1.25 7 Candida albicans (ATCC 22019) 0.3 7.5 Propionibacterium Acnes (ATCC 1916) 1.5 8.0

As shown in Table 5, when hexylene glycol and ethyl hexyl glycerine are used in combination, when hexylene glycol is added in an amount of 7 to 8 wt. Able to know. In addition, it can be seen that the combination of hexylene glycol and ethylhexyl glycerin has an antibacterial effect on various bacteria such as Escherichia coli, yeast, and acne causing bacteria.

Experimental Example 2 Preservation Effect

In order to confirm the preservative effects of the cosmetic preparations prepared in Examples 1 to 11 and Comparative Examples 1 to 6, a challenge test (Challenge Test) was performed to confirm the death by inoculating microorganisms. Escherichia coli (a liquid medium containing Tryptic Soy Broth (Difco. USA) and abouraud Dextrose Broth (Difco. USA)) and agar medium containing Tryptic Soy Agar (Difco. USA) and abouraud Dextrose Agar (Difco. USA). ATCC 9637), Pseudononas aeruginosa (ATCC 15522), Candida parapsilosis (ATCC 22019), Candida albicans (ATCC 11006), Aspergilius niger (ATCC 16404) Were inoculated respectively and incubated for 24 days under 37 ° C., anaerobic (85% N ₂ , 10% CO ₂ , 5% H ₂ ).

Escherichia which is an experimental strain cultured in the above after containing 40g each of the cosmetic composition prepared in Examples 1 to 11 and Comparative Examples 1 to 7 coli (ATCC 9637) and Pseudononas aeruginosa (ATCC 15522) were mixed and added to 10 ⁶ per g of cosmetics and mixed for 4 weeks. Then, the results of the antiseptic force measured and checked every 1, 3, 5 days from the day of inoculation of the change of inoculated bacterial counts are shown in Table 6 and Table 7 below.

division Example
One Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 inoculation
Bacteria 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 1 day later 1 × 10 ⁶ 1 × 10 ⁶ 2 × 10 ³ 1 × 10 ⁶ <20 <20 <20 1 × 10 ⁵ <20 1 × 10 ⁶ <20 3 days later <20 1 × 10 ³ <20 <20 <20 <20 <20 <20 <20 <20 <20 5 days later <20 <20 <20 <20 <20 <20 <20 <20 <20 <20 <20

division Comparative example
One Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 inoculation
Bacteria 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 1 day later 1 × 10 ⁶ 10 × 10 ⁴ 1 × 10 ⁶ 1 × 10 ⁶ 1 × 10 ⁶ 1 × 10 ⁶ 3 days later 4 × 10 ⁴ 1 × 10 ⁶ 1 × 10 ⁵ 3 × 10 ⁴ 3 × 10 ⁴ 2 × 10 ⁴ 5 days later <20 <20 <20 <20 <20 <20

Yeast which is the experimental strain cultured in the above after containing 40g each of the cosmetic composition prepared in Examples 1 to 11 and Comparative Examples 1 to 7 Candida parapsilosis (ATCC 22019) and Candida albicans (ATCC 11006) were mixed and added to 10 ⁶ per g of cosmetics and stored for 4 weeks. Then, the results of the antiseptic force measured and checked every 1, 3, 5 days from the date of inoculation of the inoculated bacterial counts are shown in Tables 8 and 9 below.

division Example
One Example 4 Example 8 Example 9 Example 10 Example 11 inoculation
Bacteria 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 1 day later 1 × 10 ⁶ <20 1 × 10 ⁶ <20 1 × 10 ⁶ <20 3 days later <20 <20 <20 <20 <20 <20 5 days later <20 <20 <20 <20 <20 <20

division Comparative example
One Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 inoculation
Bacteria 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 10 ⁶ 1 day later 1 × 10 ⁶ 1 × 10 ⁶ 1 × 10 ⁶ 1 × 10 ⁶ 1 × 10 ⁶ 1 × 10 ⁶ 3 days later 2 × 10 ⁴ 1 × 10 ⁴ 20 × 10 ⁴ 5 × 10 ⁴ 5 × 10 ⁴ 2 × 10 ⁴ 5 days later <20 <20 <20 <20 <20 <20

According to Tables 6 to 9, in the case of the cosmetic composition containing hexylene glycol or hexylene glycol and ethyl hexyl glycerin, it can be seen that the rate of microbial killing is faster than the composition of the comparative example. In addition, it can be seen that the antimicrobial activity is increased when the combination of hexylene glycol and ethyl hexyl glycerine is increased when the combination of ethyl hexyl glycerine is faster than when hexylene glycol is used alone. In addition, when hexylene glycol is used alone or in combination with ethylhexyl glycerin, it can be seen that the antimicrobial spectrum is wide because it has antimicrobial activity against various microorganisms such as bacteria and yeast.

Experimental Example 3 Skin Safety

A patch test was carried out on 30 healthy adult men and women with appropriate amounts (2.0 g) of the cosmetic composition samples of Examples 1 to 11 and Comparative Examples 1 to 7 buried inside the lower arm. After patching for 48 hours, the hazel chamber was removed, and after 1 hour, the skin condition change was read and visually judged first, and after 48 hours, the second judgment was made. Judgment criteria are as follows, and the judgment results and the stimulus degree calculation results are shown in Table 12 below.

* Criteria

－: No reaction (irritation degree: 0)

±: suspected positive reaction. Slight erythema reactions. (Stimulation degree: 0.5)

+: Slight positive reaction; Erythema, papules, positive pullback reactions (irritation degree: 1.0)

++: Severe positive reaction. Vesicular reactions: erythema, papules, infiltrating lesions, vesicles (irritation degree: 2.0)

+++: Severe positive reaction. (Stimulation degree: 3.0)

* Stimulus

division
Primary judgment (number) Second judgment (the number of people) score
- ± + ++ - ± + ++ Example 1 30 0 0 0 30 0 0 0 0.00 Example 2 30 0 0 0 30 0 0 0 0.00 Example 3 29 One 0 0 30 0 0 0 0.56 Example 4 30 0 0 0 30 0 0 0 0.00 Example 5 30 0 0 0 30 0 0 0 0.00 Example 6 30 0 0 0 30 0 0 0 0.00 Example 7 29 One 0 0 29 One 0 0 0.56 Example 8 29 One 0 0 29 One 0 0 0.56 Example 9 30 0 0 0 30 0 0 0 0.00 Example 10 30 0 0 0 30 0 0 0 0.00 Example 11 30 0 0 0 28 2 0 0 0.56 Comparative Example 1 28 2 0 0 27 3 0 0 1.38 Comparative Example 2 27 3 0 0 28 2 0 0 1.38 Comparative Example 3 30 0 0 0 28 2 0 0 0.56 Comparative Example 4 28 2 0 0 28 2 0 0 1.11 Comparative Example 5 29 One 0 0 28 2 0 0 0.83

As shown in Table 10, the cosmetic composition of the embodiment containing hexylene glycol or hexylene glycol and ethyl hexyl glycerin was found to have little skin irritation, and was safer to the skin than the composition of the comparative example.

Experimental Example 4 Measurement of Skin Moisturizing Effect

In order to examine the moisturizing power of the cosmetic composition containing hexylene glycol or hexylene glycol and hexylethyl glycerin according to the present invention, the moisture retention capacity of the cosmetic compositions of Examples 1 to 11 and Comparative Examples 1 to 7 was evaluated. After applying the samples of the cosmetic composition of the Examples and Comparative Examples to the skin in a constant temperature and humidity room maintaining 25 ℃, 40% relative humidity, the moisture retention capacity of 30 minutes, 1 hour was measured. Moisture retention was measured using Corneometer (Courage + Khazaka, GmbH, Germany) to measure the electrical conductivity of the skin surface. Twenty subjects were measured three times and their average values are shown in Tables 13 and 14.

Measure
time Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 Before application 76 75 76 76 77 75 75 75 76 75 76 apply
30 minutes later 96 92 96 92 92 92 96 98 97 85 88 apply
1 hour later 91 88 94 95 90 89 92 94 92 78 80

Measure
time Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Before application 74 75 75 73 73 73 apply
30 minutes later 85 90 85 88 84 85 apply
1 hour later 78 82 75 80 77 77

According to Table 11 and Table 12, the cosmetic composition of the embodiment of the present invention containing hexylene glycol or hexylene glycol and ethyl hexyl glycerin was superior to the comparative example water retention capacity. That is, hexylene glycol and ethylhexyl glycerin can be seen that contributes to the improvement of the moisturizing power as a polyhydric alcohol.

As described above, hexylene glycol has excellent antibacterial and moisturizing properties, no irritation to the skin, and when used in combination with ethylhexyl glycerin, the effect is further improved. Therefore, when using a combination of hexylene glycol or hexylene glycol and ethyl hexyl glycerin, it is not necessary to add a separate preservative or bactericide to the cosmetic.

Claims (3)

Cosmetic composition comprising hexylene glycol in an amount of 0.1 to 10 parts by weight based on 100 parts by weight of the total cosmetic composition. The method of claim 1, Cosmetic composition, characterized in that it further comprises 0.1 to 10 parts by weight of ethylhexyl glycerin with respect to 100 parts by weight of the total cosmetic composition. The method of claim 1, Cosmetic composition, characterized in that the formulation of the cosmetic composition is selected from the group consisting of lotion, lotion, cream, pack, cleansing and essence.