CN113476322A - Raspberry ketone antibacterial preservative and preparation method and application thereof - Google Patents
Raspberry ketone antibacterial preservative and preparation method and application thereof Download PDFInfo
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- CN113476322A CN113476322A CN202110772232.9A CN202110772232A CN113476322A CN 113476322 A CN113476322 A CN 113476322A CN 202110772232 A CN202110772232 A CN 202110772232A CN 113476322 A CN113476322 A CN 113476322A
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- agent
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- preservative
- raspberry ketone
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- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 description 1
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- PEQJBOMPGWYIRO-UHFFFAOYSA-N n-ethyl-3,4-dimethoxyaniline Chemical compound CCNC1=CC=C(OC)C(OC)=C1 PEQJBOMPGWYIRO-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Abstract
A raspberry ketone antibacterial preservative comprises raspberry ketone, dihydric alcohol and water-soluble solid polyhydric alcohol, and the raspberry ketone antibacterial preservative is solid powder or particles formed by uniformly distributing raspberry ketone after being dissolved and dispersed in water solution of the dihydric alcohol and being dried in the water-soluble solid polyhydric alcohol. The raspberry ketone antibacterial preservative provided by the invention changes the original water insolubility of raspberry ketone through a unique technical method, so that the raspberry ketone antibacterial preservative can be uniformly dispersed in a water body to play the antibacterial and preservative effects, the processes of storage, transportation, metering, use and the like are more convenient than the existing liquid antibacterial preservative, the product performance is stable, the use is convenient, the effect is reliable, the addition types of the antibacterial preservative can be reduced during use, various application scenes are adapted, different requirements of users are met, and the raspberry ketone antibacterial preservative serving as an antibacterial preservative taking a natural product as a main body is more easily accepted by the users, so that the raspberry ketone antibacterial preservative has great popularization and application values.
Description
Technical Field
The invention relates to an antibacterial preservative and a preparation method and application thereof, in particular to a raspberry ketone antibacterial preservative and a preparation method and application thereof, and belongs to the technical field of production, manufacture and application of antibacterial preservatives.
Background
Raspberry ketone, the english name is 4- (4-hydroxypentyl) -2-butanone, and the chinese name includes: raspberry flavone, raspberry ketone, rasidone, natural raspberry ketone, p-hydroxy butanone, raspberry ketone and the like.
The chemical names of raspberry ketone include: 4- (4-hydroxyphenyl) -2-butanone, 4- (p-hydroxyphenyl) -2-butanone, 4-p-hydroxyphenyl-2-butanone, 4- (4-hydroxyphenyl) butyl-2-one, 4- (4-hydroxyphenyl) -2-butanone, 4-hydroxybenzylacetone and the like.
The molecular formula of raspberry ketone is C10H12O2The raspberry fruit essence is a white acicular crystal or granular solid with the molecular weight of 164.22, the melting point of 82-83 ℃ and the boiling point of 200 ℃, is in raspberry fragrance and fruit fragrance sweet taste, is insoluble in water and petroleum ether, is soluble in ethanol, diethyl ether and volatile oil, exists in natural products such as raspberry (raspberry), is also a synthetic product at present, is mainly prepared by condensing hydroxybenzaldehyde and acetone and then hydrogenating, or is prepared by condensing tetronic acid and phenol, is mainly used as a spice, is used for preparing food spices, has the functions of increasing fragrance and sweetening, and can also be used in cosmetics and soap essence.
With the progress of the research, in recent years, raspberry ketone has been found and demonstrated to have preservative and antibacterial activity, as noted in the publication of raspberry flavone bacteriostatic properties study by huixianxia:
raspberry flavone has a strong inhibitory effect on escherichia coli, bacillus subtilis and staphylococcus aureus (modern food science and technology 2012, vol.28, No.11, page 1487).
However, practical application of raspberry ketone as bacteriostatic preservative has certain difficulties and limitations:
firstly, the raspberry ketone is insoluble in water and petroleum ether and only soluble in ethanol, diethyl ether and volatile oil, so that for products or application scenes mainly taking water as a dispersion medium, the raspberry ketone cannot be dissolved and diffused in the water, and therefore, a good antibacterial preservative effect cannot be achieved;
secondly, raspberry ketone has a relatively thick fragrance, and when the raspberry ketone is used alone, the raspberry ketone has certain irritation, which can cause irritation to skin, certainly, the raspberry ketone is an indispensable bacteriostatic and preservative product for products requiring a thick fragrance, and for products not requiring a thick fragrance or only needing a slight and soft fragrance, raspberry ketone is simply and directly used as a bacteriostatic preservative, which is obviously not suitable;
in addition, experiments show that raspberry purified flavone shows different antibacterial properties to different thalli, high temperature has a destructive effect on antibacterial components of raspberry flavone, the pH value range also has a certain influence on antibacterial activity of raspberry ketone, and when the pH value is increased to 9, the antibacterial activity of raspberry ketone is weakened.
In summary, it can be seen that:
raspberry ketone as a novel antibacterial preservative has wide application prospect, but the action, the application range and the application scene of the raspberry ketone are greatly limited in the existing application mode, and the antibacterial and preservative effects of the raspberry ketone are not well played and utilized.
Although the invention patent CN111407682B provides a cosmetic preservative, which comprises 22% of raspberry ketone, 13% of sodium dehydroacetate, dihydric alcohol and solubilizer, wherein the dihydric alcohol is 55% of 1, 2-octanediol, the solubilizer is 8.0% of alkyl glycoside and 2.0% of fatty alcohol polyoxyethylene ether, and the cosmetic preservative does not contain formaldehyde releaser, paraben and isothiazolinone, has broad-spectrum antibacterial and bactericidal capability, can not only have good preservative effect, but also reduce the consumption of the preservative, has small mild irritation to skin and is particularly suitable for sensitive skin.
However, it can be seen that the cosmetic preservative actually comprises two bacteriostatic preservatives, namely a mixture of raspberry ketone and sodium dehydroacetate, and the raspberry ketone alone plays a role in bacteriostatic preservation. Although the current experiments prove that the sodium dehydroacetate is nontoxic and harmless to the environment, the withdrawal of people for the disease is not excluded under the large background that people generally use the multi-purpose bacteriostatic preservative for the Xinxianjia.
Therefore, the substances obtained from natural products or the substances synthesized by taking the natural products as samples are developed to carry out bacteriostasis and preservation on the products, the addition amount and the addition type of the bacteriostasis and preservation agent can be reduced in the products, and the products produced by adopting the bacteriostasis and preservation agent obviously can be more popular among consumers.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a raspberry ketone antibacterial preservative on one hand, a preparation method of the raspberry ketone antibacterial preservative on the other hand, and simultaneously provides application modes of various raspberry ketone antibacterial preservatives, aiming at:
the antibacterial preservative taking a natural product as a main body is developed, the adding types of the antibacterial preservative are reduced on the premise of providing an effective antibacterial and preservative effect, the antibacterial preservative is suitable for various application scenes, and different requirements of users are met.
In order to achieve the purpose, the invention firstly provides a raspberry ketone antibacterial preservative.
The raspberry ketone antibacterial preservative provided by the invention comprises raspberry ketone, dihydric alcohol and water-soluble solid polyhydric alcohol, and
the raspberry ketone antibacterial preservative is solid powder or particles formed by uniformly distributing raspberry ketone in water-soluble solid polyol after the raspberry ketone is dissolved and dispersed in a water solution of dihydric alcohol, wherein:
the raspberry ketone antibacterial preservative comprises, by weight, 10-30 parts of raspberry ketone, 2-15 parts of a dihydric alcohol aqueous solution and 45-65 parts of water-soluble solid polyhydric alcohol.
Further, in the raspberry ketone antibacterial preservative provided by the invention:
the dihydric alcohol is one or more of 1, 3-propylene glycol, butanediol, 2, 3-butanediol, dipropylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, caprylyl glycol, methyl propylene glycol, polyethylene glycol and ethylhexyl glycerin;
the water-soluble solid polyalcohol is one or a mixture of two of sorbitol and mannitol.
Secondly, the invention also provides a preparation method of the raspberry ketone antibacterial preservative, and the preparation method of the raspberry ketone antibacterial preservative comprises the following steps:
dissolving raspberry ketone in aqueous solution of dihydric alcohol to obtain raspberry ketone dihydric alcohol solution;
crushing water-soluble solid polyol into powder, placing the powder in a container, and introducing heating and drying gas with the temperature not higher than 65 ℃ to enable the powdery water-soluble solid polyol to be in a heating boiling state;
spraying the raspberry ketone binary alcohol solution on the powdery water-soluble solid polyol in a heating boiling state by a spraying method, and drying to obtain the raspberry ketone antibacterial preservative.
Thirdly, on the basis of the raspberry ketone antibacterial preservative provided by the invention, the invention also provides application modes of the raspberry ketone antibacterial preservative, wherein the raspberry ketone antibacterial preservative comprises a ceramide repair essence milk which comprises the following components in parts by weight:
an emulsifier, a first thickener, an emollient, an antioxidant, a humectant, a first skin-feel conditioner, a second thickener, a chelating agent, a second skin-feel conditioner, a preservative, an aromatizing agent and a solvent, wherein the preservative is the raspberry ketone bacteriostatic preservative of any one of claims 1-2;
the ceramide repair essence milk comprises the following components in parts by weight based on 100 parts by weight:
10-20 parts by weight of an emulsifier, 0.5-1.5 parts by weight of a first thickener, 5-15 parts by weight of an emollient, 0.2-0.8 part by weight of an antioxidant, 5-15 parts by weight of a humectant, 0.1-0.5 part by weight of a first skin feel conditioner, 0.5-1 part by weight of a second thickener, 0.02-0.08 part by weight of a chelating agent, 0.5-2 parts by weight of a second skin feel conditioner, 1-2 parts by weight of a preservative, 0.05-0.15 part by weight of an aromatizing agent, and the balance of a solvent.
Further, the ceramide repair essence milk comprises:
the emulsifier is one or a mixture of two of olive oil polyglycerol-6 esters and sodium stearoyl lactylate;
the first thickening agent is cetostearyl alcohol;
the emollient is one or more of shea butter, hydrogenated polydecene, isononyl isononanoate, polydimethylsiloxane and dimethiconol;
the antioxidant is tocopherol acetate;
the humectant is one or a mixture of more of glyceryl polyether-26, butanediol and erythritol;
the first skin feeling conditioning agent is one or a mixture of two of allantoin or sodium hyaluronate;
the second thickening agent is one or a mixture of two of xanthan gum and hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer;
the chelating agent is EDTA disodium;
the second skin feel conditioning agent is one or a mixture of glycerol, octyldodecanol, hydrogenated lecithin, ceramide 3, phytosterol/octyldodecanol lauroyl glutamate, 1, 2-hexanediol and oat kernel extract;
the flavoring agent is essence for daily use;
the solvent is water.
Further, the preparation method of the ceramide repair essence milk provided by the invention comprises the following steps:
mixing the emulsifier, the first thickener, the emollient and the antioxidant together, stirring and heating until completely dissolving to form a phase A;
mixing the moisturizer, the first skin feel conditioner, the second thickener, the chelating agent and part of the solvent together, stirring and heating until all the materials are uniformly dispersed to form a phase B;
mixing the second skin-feel conditioner, the preservative, the aromatizing agent and part of the solvent together, stirring and heating until the materials are uniformly dispersed to form a phase C;
adding the phase A into the phase B, heating and homogenizing until complete emulsification forms an AB mixed phase, and cooling;
adding the phase C into the mixed phase AB, and uniformly stirring; wherein:
the heating temperature for preparing the phase A is 70-75 ℃, the heating temperature for preparing the phase B is 80-85 ℃, and the temperature of the AB mixed phase is kept about 45 ℃ when the phase C is added into the AB mixed phase.
In addition, in the application mode of the raspberry ketone antibacterial preservative provided by the invention, the raspberry ketone antibacterial preservative also comprises a relieving makeup removing wet tissue, and the relieving makeup removing wet tissue comprises:
surfactant, chelating agent, skin feel conditioner, humectant, aromatizer, solubilizer, preservative and solvent, wherein the preservative is the raspberry ketone antibacterial preservative as claimed in any one of claims 1-2, wherein the total amount is 100 parts by weight:
2-6 parts by weight of surfactant, 0.02-0.1 part by weight of chelating agent, 1.5-2.5 parts by weight of skin-feel conditioner, 2-4 parts by weight of humectant, 0.01-0.03 part by weight of aromatizer, 0.05-0.15 part by weight of solubilizer, 1-1.5 parts by weight of preservative, and the balance of solvent.
Further, in the soothing makeup removing wet tissue:
the skin-feel conditioning agent is one or a mixture of more of oat kernel extract, fructo-oligosaccharide, cocamidopropyl PG-dimethyl ammonium chloride phosphate and aloe vera, the humectant is glycerin, the flavoring agent is essence, and the solubilizer is PEG-40 hydrogenated castor oil.
Further, the preparation method of the soothing makeup-removing wet tissue provided by the invention comprises the following steps:
adding the surfactant, the chelating agent, the skin-feel conditioner and the humectant into the solvent in sequence, and stirring uniformly in sequence to form a phase A;
dissolving the aromatizing agent in the solubilizer, and stirring uniformly to form a phase B;
adding the phase B into the phase A, stirring and mixing uniformly, then adding the preservative, and stirring and mixing uniformly to form a makeup removing mixed solution;
immersing the non-woven fabric in the makeup removing mixed liquid to enable the non-woven fabric to fully adsorb the makeup removing mixed liquid, taking out the non-woven fabric adsorbing the makeup removing mixed liquid, and cutting the non-woven fabric according to a set specification to obtain the makeup removing wet tissue.
Further, in the application mode of the raspberry ketone antibacterial preservative provided by the invention, the raspberry ketone antibacterial preservative also comprises a repairing and conditioning shampoo, and the repairing and conditioning shampoo comprises the following components:
a suspending agent, a chelating agent, a first surfactant, a thickening agent, a pearlescing agent, a fat-endowing agent, a second surfactant, a cation conditioner, a conditioner, an antioxidant, an aromatizing agent, a preservative and a solvent, wherein the preservative is the raspberry ketone antibacterial preservative as defined in any one of claims 1-2, wherein:
the repairing and conditioning shampoo comprises the following components in parts by weight based on 100 parts by weight:
0.2-0.5 part by weight of a suspending agent, 0.005-0.015 part by weight of a chelating agent, 30-35 parts by weight of a first surfactant, 1.0-2.5 parts by weight of a thickening agent, 1.0-2.5 parts by weight of a pearling agent, 1.0-2.5 parts by weight of a fat-liquoring agent, 10-12 parts by weight of a second surfactant, 0.3-0.6 part by weight of a cation conditioner, 3.5-5.5 parts by weight of a conditioner, 0.025-0.075 part by weight of an antioxidant, 0.2-0.6 part by weight of an aromatizing agent, 1-1.5 parts by weight of a raspberry ketone antibacterial preservative, and the balance of a solvent.
Further, in the repairing and conditioning shampoo:
the suspending agent is carbomer, the chelating agent is disodium edetate, the first surfactant is a mixture of sodium laureth sulfate and sodium dodecyl sulfate in a ratio of 1: 0.88, the thickening agent is coconut oil fatty acid monoethanolamide, the pearling agent is ethylene glycol stearic acid diester, the fatting agent is cetostearyl alcohol, the second surfactant is a mixture of ammonium xylene sulfonate, cocamidopropyl betaine and sodium lauroyl sarcosinate according to the ratio of 1: 5, the cationic conditioner is cationic guar gum, the conditioner is a mixture prepared from cationic panthenol, amino silicone oil, small-particle-size emulsified silicone oil TC-1352 and large-particle-size emulsified silicone oil TC-3560 according to the ratio of 1: 0.5: 1: 2, the antioxidant is vitamin E, and the flavoring agent is essence.
Further, the preparation method of the repairing and conditioning shampoo provided by the invention comprises the following steps:
mixing the fatting agent and the second surfactant to form a second surfactant mixture;
adding the suspending agent into the solvent, stirring uniformly, then sequentially adding a chelating agent, a first surfactant, a thickening agent and a pearling agent, heating and stirring until all solid materials are completely dissolved and uniformly dispersed to obtain a first mixed solution;
adding the second surfactant mixture into the first mixed solution, and uniformly stirring to obtain a second mixed solution;
adding the cationic conditioner into the second mixed solution, uniformly stirring, preserving heat for a period of time to fully fuse all materials, and then carrying out first cooling to obtain a third mixed solution;
adding the conditioner and the antioxidant into the third mixed solution, and uniformly stirring to obtain a fourth mixed solution;
cooling the fourth mixed solution for the second time, then adding the aromatizer and the preservative into the fourth mixed solution, and stirring and mixing uniformly to obtain the repairing conditioning shampoo; wherein:
the heating temperature during the preparation of the first mixed solution is 70-75 ℃, the heat preservation temperature during the preparation of the third mixed solution is 70-75 ℃ and the heat preservation time is not less than 30 minutes, the final temperature during the first cooling is controlled to be about 60 ℃, and the final temperature during the second cooling of the fourth mixed solution is controlled to be about 45 ℃.
Further, in an application mode of the raspberry ketone antibacterial preservative provided by the invention, the raspberry ketone antibacterial preservative further comprises a glycogen skin-brightening and firming mask, wherein the glycogen skin-brightening and firming mask comprises:
the raspberry ketone bacteriostatic and preservative comprises a humectant, a chelating agent, a film forming agent, a suspending agent, a whitening agent, a gel agent, a penetrating agent, a pH regulator, a skin feel conditioner, an anti-inflammatory agent, a preservative and a solvent, wherein the preservative is the raspberry ketone bacteriostatic and preservative as claimed in any one of claims 1-2, and the repairing and conditioning shampoo comprises the following components in parts by weight based on 100 parts:
the anti-inflammatory raspberry ketone skin conditioner comprises, by weight, 6-8 parts of a humectant, 0.01-0.05 part of a chelating agent, 0.1-0.3 part of a film forming agent, 0.1-0.15 part of a suspending agent, 1-3 parts of a whitening agent, 0.05-0.15 part of a gelling agent, 2-4 parts of a penetrating agent, 0.5-0.8 part of a pH regulator, 5-8 parts of a skin conditioning agent, 0.05-0.15 part of an anti-inflammatory agent, 1-1.5 parts of a raspberry ketone antibacterial preservative and the balance of a solvent.
Further, in the glycogen skin-lightening and firming mask:
the skin feeling conditioner is a mixture prepared from 1:1.5:1 of sodium hyaluronate containing 1% of low molecular weight sodium hyaluronate, 1% of sodium hyaluronate containing 1% of medium molecular weight sodium hyaluronate and 1% of sodium hyaluronate containing 1% of high molecular weight sodium hyaluronate, and an oat kernel extract, and the anti-inflammatory agent is dipotassium glycyrrhizinate.
Further, the preparation method of the glycogen skin-brightening and firming mask provided by the invention comprises the following steps:
adding the humectant, the chelating agent, the film forming agent, the suspending agent, the whitening agent and the gel into the solvent, stirring and heating until the components are dissolved and dispersed uniformly to form a phase A, and then cooling and preserving heat;
stirring the penetrant, the pH regulator, the skin-feel conditioner and the anti-inflammatory agent uniformly to form a phase B;
adding the phase B into the phase A, stirring and mixing uniformly, then adding the preservative, and stirring and mixing uniformly to obtain the glycogen skin-brightening and tightening mask; wherein:
the heating temperature for preparing the phase A is 75-85 ℃, and the cooling and heat preservation temperature is 45-55 ℃.
Compared with the prior art, the invention has the beneficial effects and remarkable progresses that:
1) the raspberry ketone antibacterial preservative provided by the invention comprises raspberry ketone, dihydric alcohol and water-soluble solid polyhydric alcohol, and the raspberry ketone antibacterial preservative is solid powder or particles formed by uniformly distributing raspberry ketone in water-soluble solid polyhydric alcohol after the raspberry ketone is dissolved and dispersed by aqueous solution of the dihydric alcohol and is dried;
2) the raspberry ketone antibacterial preservative provided by the invention is characterized in that a water-insoluble antibacterial preservative main substance, namely raspberry ketone, is dissolved and dispersed in a water-soluble solid polyol through a water solution of dihydric alcohol and then is uniformly distributed in the water-soluble solid polyol, when the water-soluble solid polyol is dissolved and dispersed in water, raspberry ketone molecules which are dissolved and dispersed and wrapped by the water solution of the dihydric alcohol are dispersed in a water body along with the dissolution of the water solution of the dihydric alcohol, so that the original common application field of water-insoluble substances is changed, the raspberry ketone molecules can be uniformly dispersed in the water body to play the antibacterial and preservative effects of the raspberry ketone molecules, and the raspberry ketone antibacterial preservative can be applied to various products which take water as a main carrier or a main solvent to be used as an antibacterial preservative;
3) according to the raspberry ketone antibacterial preservative provided by the invention, raspberry ketone is dissolved and dispersed by the aqueous solution of dihydric alcohol and then uniformly distributed in the water-soluble solid polyhydric alcohol to form solid powder or particles, and the storage, transportation, metering, use and other processes of the raspberry ketone antibacterial preservative are more convenient than those of the raspberry ketone dissolved in a solvent to form a liquid antibacterial preservative, so that the raspberry ketone antibacterial preservative is more convenient for users to accept;
4) the raspberry ketone antibacterial preservative provided by the invention has strong raspberry fragrance, and after the raspberry ketone is dissolved and dispersed in the aqueous solution of dihydric alcohol and then uniformly distributed in the water-soluble solid polyhydric alcohol, the raspberry ketone antibacterial preservative is dispersed by the dihydric alcohol and the water-soluble solid polyhydric alcohol and encapsulates part of fragrance emitted by the raspberry ketone, so that the raspberry ketone antibacterial preservative can be suitable for products which are difficult to emit strong fragrance, and soft and warm raspberry fragrance can be kept for a longer time;
5) the raspberry ketone antibacterial preservative provided by the invention changes the physical properties of raspberry ketone by adopting a unique technical means, thereby expanding the application field, so that the antibacterial preservative substance obtained from natural plants can be widely applied to daily products, has the functions of bacteriostasis and corrosion prevention, has clear, unique, creative and inspirational ideas for solving the technical problems, is novel and ingenious in the adopted technical means, is unique and creative, and has stable product performance, convenient use and reliable effect, thereby having great popularization and application values.
Drawings
To more clearly illustrate the technical solution of the present invention, the drawings related to the embodiments of the present invention will be briefly described below.
Obviously:
the drawings in the following description are only part of the embodiments of the present invention, and it is obvious to those skilled in the art that other drawings can be obtained according to the drawings without creative efforts, but the other drawings also belong to the drawings required to be used by the embodiments of the present invention.
FIG. 1 is a diagram of a detection result of inhibitory effects of Ft-001 batch raspberry ketone bacteriostatic preservative on Escherichia coli provided by an embodiment of the invention;
FIG. 2 is a diagram showing the detection result of the Ft-001 batch raspberry ketone bacteriostatic preservative on the inhibition effect of pseudomonas aeruginosa according to the embodiment of the invention;
FIG. 3 is a graph of a detection result of inhibitory effects of Ft-001 batch raspberry ketone bacteriostatic preservative on Staphylococcus aureus, provided by an embodiment of the invention;
FIG. 4 is a graph showing the results of detecting the inhibitory effect of Ft-001 batch of raspberry ketone bacteriostatic preservative on Candida albicans;
FIG. 5 is a graph of the results of detection of inhibition effects of Ft-001 batch of raspberry ketone bacteriostatic preservative on Aspergillus niger;
FIG. 6 is a diagram of a detection result of inhibitory effects of Ft-002 batch raspberry ketone bacteriostatic preservative on Escherichia coli provided by an embodiment of the invention;
FIG. 7 is a diagram showing the result of detection of the inhibitory effect of Ft-002 batch raspberry ketone bacteriostatic preservative on Pseudomonas aeruginosa according to the embodiment of the invention;
fig. 8 is a diagram of a detection result of inhibitory effects of Ft-002 batch raspberry ketone bacteriostatic preservative on Staphylococcus aureus provided by the embodiment of the invention;
fig. 9 is a diagram of a detection result of the inhibitory effect of Ft-002 batch raspberry ketone bacteriostatic preservative on Candida albicans provided by the embodiment of the invention;
FIG. 10 is a graph of the results of detection of inhibition effects of Ft-002 batch raspberry ketone bacteriostatic preservative on Aspergillus niger provided by the embodiment of the invention;
FIG. 11 is a graph of the results of detection of inhibitory effects of Ft-003 lot raspberry ketone bacteriostatic preservatives on Escherichia coli provided by embodiments of the present invention;
FIG. 12 is a diagram showing the results of detection of the inhibitory effect of Ft-003 batch raspberry ketone bacteriostatic preservative on Pseudomonas aeruginosa according to the embodiment of the invention;
fig. 13 is a graph of a detection result of inhibitory effects of an Ft-003 batch of raspberry ketone bacteriostatic preservative on Staphylococcus aureus, provided by an embodiment of the present invention;
FIG. 14 is a graph showing the results of detecting the inhibitory effect of raspberry ketone bacteriostatic preservative on Candida albicans in batches Ft-003 according to the embodiment of the present invention;
fig. 15 is a detection result graph of the inhibition effect of the Ft-003 batch of raspberry ketone bacteriostatic preservative on aspergillus niger.
Detailed Description
In order to make the objects, technical solutions, advantages and significant progress of the embodiments of the present invention clearer and more obvious, the technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the drawings provided in the embodiments of the present invention, it is obvious that all the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments, and all other embodiments obtained by a person of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.
It should be noted that:
the terms "first," "second," and "third" (if any), etc. in the description and claims of the present invention and the accompanying drawings of embodiments of the present invention are used for distinguishing between different objects and not for describing a particular order; furthermore, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to the listed steps or elements, but may alternatively include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
It should also be noted that:
the following embodiments may be combined with each other, and the same or similar concepts or processes may not be described in detail in some embodiments;
materials, devices and the like mentioned in the following examples are commercially available, and the detection methods and the like adopted are relevant operation procedures and detection standards in the prior art except for specific description.
The technical means of the present invention will be described in detail below with specific examples.
Example one
The embodiment provides a raspberry ketone antibacterial preservative, a preparation method thereof and an effect detection result.
Firstly, the raspberry ketone antibacterial preservative provided by the embodiment.
The raspberry ketone antibacterial preservative provided by the embodiment comprises raspberry ketone, a water solution of dihydric alcohol and water-soluble solid polyhydric alcohol; and is
The raspberry ketone antibacterial preservative is solid powder or particles formed by uniformly distributing raspberry ketone after being dissolved and dispersed in a dihydric alcohol aqueous solution in water-soluble solid polyhydric alcohol and being dried.
Specifically, the raspberry ketone antibacterial preservative comprises the following components in parts by weight:
10-30 parts of raspberry ketone, 2-15 parts of a dihydric alcohol aqueous solution and 40-65 parts of water-soluble solid polyhydric alcohol.
In a preferred proportioning combination, the raspberry ketone antibacterial preservative comprises the following components in parts by weight:
20 parts by weight of raspberry ketone, 5 parts by weight of aqueous solution of dihydric alcohol and 50 parts by weight of water-soluble solid polyhydric alcohol.
In the raspberry ketone antibacterial preservative provided by the embodiment, the following materials can be selected for compatibility:
the dihydric alcohol can be selected from one or more of 1, 3-propylene glycol, butanediol, 2, 3-butanediol, dipropylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, octyl glycol, methyl propylene glycol, polyethylene glycol, and ethyl hexyl glycerol;
the water-soluble solid polyol can be one or two of sorbitol and mannitol.
The preparation method of the raspberry ketone antibacterial preservative provided by the embodiment comprises the following steps:
dissolving raspberry ketone in aqueous solution of dihydric alcohol to obtain raspberry ketone dihydric alcohol solution;
crushing the water-soluble solid polyol into powder, and putting the powder into a container to be filled with heated dry gas so as to enable the powder-shaped water-soluble solid polyol to be in a heating boiling state;
spraying the raspberry ketone binary alcohol solution on powdered water-soluble solid polyhydric alcohol in a heating boiling state by a spraying method, and drying to obtain the raspberry ketone antibacterial preservative.
The preparation method of the raspberry ketone antibacterial preservative comprises the following steps:
drying raspberry ketone diol solution by spraying onto powdered water-soluble solid polyol in boiling state, and introducing heated drying gas with temperature not higher than 65 deg.C.
In order to clearly illustrate the effect of the raspberry ketone antibacterial preservative provided in this example, raspberry ketone antibacterial preservative samples obtained by a specific preparation method are provided below, and the raspberry ketone antibacterial preservative samples are detected, and the effect of the raspberry ketone antibacterial preservative samples is illustrated by detection, where:
table 1 is a material formula table of three batches of detection samples for detecting the effect of the raspberry ketone antibacterial preservative, which are prepared by the preparation method of the raspberry ketone antibacterial preservative provided in this embodiment and the component substances and the mixture ratio thereof;
table 2 shows the data of the test results of the related batches of raspberry ketone antibacterial preservatives in table 1, wherein:
1) percent Minimum inhibitory concentration (Minimum inhibitory concentration, abbreviation: MIC) according to a detection method specified in disinfection technical Specification 2017 edition published by Ministry of health of the people's republic of China;
2) the antioxidant activity test adopts DPPH clearance test to detect, wherein:
2.1) preparation of DPPH test solution: weighing 10mg of DPPH, adding the DPPH into 20mL of absolute ethyl alcohol, performing ultrasonic treatment for 5min, and adding 18mL of absolute ethyl alcohol into 2mL of solution for dilution;
2.2) preparing raspberry ketone bacteriostatic preservative sample solution as follows: dissolving the raspberry ketone antibacterial preservative prepared in the embodiment by using 1.3-butanediol as a solvent, firstly preparing a stock solution containing 1% of raspberry ketone, and then diluting according to experimental needs, wherein the diluting method comprises the steps of adding absolute ethyl alcohol into the stock solution to dilute the stock solution until the concentration is required by detection;
2.3) the test method is as follows: taking 2mL of 0.05g/LDPPH solution in a test tube, and adding 1mL of absolute ethanol solution to form a blank reference solution; 60 mu L of sample is added with 940 mu L of absolute ethyl alcohol to form a test solution; mixing the blank reference solution and the detected solution in a test tube uniformly, reacting at normal temperature for 30min, absorbing 200 mu L, transferring to a 96-well plate, measuring absorbance at 517nm by using an enzyme-labeling instrument, and calculating DPPH clearance according to the following formula:
3) the whitening activity is judged by adopting a tyrosinase inhibition rate experiment, wherein:
3.1) reagents comprising: disodium hydrogen phosphate buffer solution with pH 6.8, levodopa absolute ethanol solution with 1mg/mL, and 1000U tyrosinase solution prepared by diluting disodium hydrogen phosphate buffer solution with pH 6.8;
3.2) the solution of the sample to be detected is: 0.015mg of the raspberry ketone antibacterial preservative prepared in the embodiment is taken firstly, 0.485mL of disodium hydrogen phosphate buffer solution is added for dissolution, then 0.3mL is removed, and 0.2mL of disodium hydrogen phosphate buffer solution is added and mixed uniformly to obtain the raspberry ketone antibacterial preservative.
Table 1:
table 2:
from tables 1 and 2, it can be seen that:
according to the raspberry ketone antibacterial preservative formula and the preparation method thereof provided by the embodiment, the raspberry ketone antibacterial preservative which is required by compounding the appearance and other physical and chemical indexes can be prepared, and an antioxidant activity test, a whitening activity test and a minimum antibacterial concentration test prove that the prepared raspberry ketone antibacterial preservative has antibacterial effect and antioxidant activity which meet the requirements of serving as the antibacterial preservative, and has no whitening activity, so that the raspberry ketone antibacterial preservative can be used as an antibacterial preservative which takes a substance obtained from a natural product or a substance synthesized by taking the natural product as a sample as a main body, and is popular with consumers.
It is to be noted in particular that:
although table 1 only lists three raspberry ketone antimicrobial preservatives prepared from raspberry ketone, aqueous solutions of different specific diols, water-soluble solid polyols and weights, and table 2 also only lists the detection results of raspberry ketone antimicrobial preservatives prepared from the specific composition formulas and weight compositions adopted in table 1, experiments prove that:
according to the formula of 10-30 parts by weight of raspberry ketone, 2-15 parts by weight of aqueous solution of dihydric alcohol and 40-65 parts by weight of water-soluble solid polyhydric alcohol provided by the embodiment, and the dihydric alcohol is selected from one or a mixture of more of 1, 3-propylene glycol, butanediol, 2, 3-butanediol, dipropylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, caprylyl glycol, methyl propylene glycol, polyethylene glycol and ethylhexylglycerin, the water-soluble solid polyalcohol is selected from one or a mixture of two of sorbitol and mannitol for various combination compatibility, the raspberry ketone antibacterial preservative meeting the requirements can be prepared and produced, the results of the tests are substantially the same as those of the raspberry ketone bacteriostatic preservative in the batch listed in table 2, and for the sake of brevity, the detailed description is omitted and only a general description is provided here.
From the above description, it can be seen that:
firstly, the raspberry ketone antibacterial preservative provided by the embodiment comprises raspberry ketone, a water solution of dihydric alcohol and water-soluble solid polyhydric alcohol, and the raspberry ketone antibacterial preservative is solid powder or particles formed by uniformly distributing raspberry ketone in the water-soluble solid polyhydric alcohol after the raspberry ketone is dissolved and dispersed in the water solution of the dihydric alcohol and is dried;
secondly, in the raspberry ketone antibacterial preservative provided by this embodiment, a water-insoluble antibacterial preservative main substance, namely raspberry ketone, is dissolved and dispersed in a water-soluble solid polyol through a glycol aqueous solution and then uniformly distributed in the water-soluble solid polyol, when the water-soluble solid polyol is dissolved and dispersed in water, raspberry ketone molecules which are dissolved and dispersed and wrapped by the glycol aqueous solution are dispersed in a water body along with the dissolution of the glycol aqueous solution in water, so that the original common application field of water-insoluble substances is changed, the raspberry ketone molecules can be uniformly dispersed in the water body to play a role in antibacterial and preservative, and therefore, the raspberry ketone antibacterial preservative can be applied to various products which take water as a main carrier or a main solvent and can be used as an antibacterial preservative;
thirdly, in the raspberry ketone antibacterial preservative provided by the embodiment, the raspberry ketone is dissolved and dispersed by the aqueous solution of the dihydric alcohol and then uniformly distributed in the water-soluble solid polyhydric alcohol to form solid powder or particles, and the storage, transportation, metering, use and other processes of the raspberry ketone antibacterial preservative are more convenient than those of the raspberry ketone dissolved in the solvent to form the liquid antibacterial preservative, so that the raspberry ketone antibacterial preservative is more convenient for users to accept;
in addition, the raspberry ketone antibacterial preservative provided by the embodiment has strong raspberry fragrance, and after the raspberry ketone is dissolved and dispersed in the aqueous solution of the dihydric alcohol and then uniformly distributed in the water-soluble solid polyol, the raspberry ketone is dispersed by the dihydric alcohol and the water-soluble solid polyol and encapsulates part of fragrance emitted by the raspberry ketone, so that the raspberry ketone antibacterial preservative can be suitable for products which are not easy to emit strong fragrance, and soft and warm raspberry fragrance can be maintained for a longer time;
in addition, the raspberry ketone antibacterial preservative provided by the embodiment adopts a unique technical means to change the physical properties of raspberry ketone, so that the application field is expanded, the antibacterial preservative substance obtained from natural plants can be widely applied to daily products, and has the antibacterial and preservative effects.
Example two
The embodiment provides the application of the raspberry ketone antibacterial preservative provided in the first embodiment in various products, and an application mode and an application effect thereof.
Case 1
The present case provides an embodiment of an application of the raspberry ketone antibacterial preservative provided in the first embodiment of the present invention in a ceramide repair essence milk, and the ceramide repair essence milk includes:
an emulsifier, a first thickener, an emollient, an antioxidant, a humectant, a first skin conditioning agent, a second thickener, a chelating agent, a second skin conditioning agent, a preservative, an aroma-imparting agent, and a solvent, wherein:
the preservative is any one raspberry ketone antibacterial preservative obtained in the first embodiment.
In the embodiment, the ceramide repair essence milk comprises the following components in parts by weight:
10-20 parts of emulsifier, 0.5-1.5 parts of first thickener, 5-15 parts of emollient, 0.2-0.8 part of antioxidant, 5-15 parts of humectant, 0.1-0.5 part of first skin feel conditioner, 0.5-1 part of second thickener, 0.02-0.08 part of chelating agent, 0.5-2 parts of second skin feel conditioner, 1-2 parts of preservative, 0.05-0.15 part of flavoring agent and the balance of solvent.
In a preferred embodiment, the ceramide repair essence milk comprises the following components in parts by weight:
15 parts of emulsifier, 1 part of first thickener, 8 parts of emollient, 0.5 part of antioxidant, 10 parts of humectant, 0.22 part of first skin-feel conditioner, 0.7 part of second thickener, 0.05 part of chelating agent, 1.5 parts of second skin-feel conditioner, 1.2 parts of preservative, 0.1 part of fragrance-imparting agent and the balance of solvent.
Specifically, the ceramide repair essence milk comprises the following components in percentage by weight:
the emulsifier is one or a mixture of two of olive oil polyglycerol-6 esters and sodium stearoyl lactylate;
the first thickening agent is cetostearyl alcohol;
the emollient is one or more of shea butter, hydrogenated polydecene, isononyl isononanoate, polydimethylsiloxane, and dimethiconol;
the antioxidant is tocopherol acetate;
the humectant is one or more of glyceryl polyether-26, butanediol, and erythritol;
the first skin feeling conditioning agent is one or a mixture of two of allantoin or sodium hyaluronate;
the second thickener is one or a mixture of two of xanthan gum and hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer;
the chelating agent is EDTA disodium;
the second skin feeling conditioning agent is one or more of glycerol, octyldodecanol, hydrogenated lecithin, ceramide 3, phytosterol/octyldodecanol lauroyl glutamate, 1, 2-hexanediol, and oat kernel extract;
the flavoring agent is essence for daily use;
the solvent is water.
In this embodiment, the preparation method of the ceramide repair essence milk comprises the following steps:
mixing the emulsifier, the first thickener, the emollient and the antioxidant together, stirring and heating until the emulsifier, the first thickener, the emollient and the antioxidant are completely dissolved to form a phase A;
mixing the humectant, the first skin-feel conditioner, the second thickener, the chelating agent and part of the solvent together, stirring and heating until all the materials are uniformly dispersed to form a phase B;
mixing the second skin-feel conditioner, the preservative, the aromatizing agent and part of the solvent together, stirring and heating until all the materials are uniformly dispersed to form a phase C;
adding phase A into phase B, heating and homogenizing to completely emulsify to form AB mixed phase, and cooling;
adding phase C into the AB mixed phase, and stirring uniformly.
In the preparation process of the ceramide repair essence milk:
when preparing phase A, the heating temperature is 70-75 ℃;
when preparing phase B, the heating temperature is 80-85 ℃;
when the phase C is added into the AB mixed phase, the temperature of the AB mixed phase is kept at about 45 ℃.
As a specific example embodiment, table 3 lists a ceramide repair essence milk product prepared by compounding according to the formula of the ceramide repair essence milk and preparing according to the preparation method of the ceramide repair essence milk, and the test results of the ceramide repair essence milk product prepared according to the compounding formula given in table 3 are given in table 8.
TABLE 3
The following are specifically mentioned:
table 3 shows only one ceramide repair essence milk product prepared by the compatibility of the ceramide repair essence milk formula provided in the present example and the preparation method of the ceramide repair essence milk, and table 8 shows only the detection results of the ceramide repair essence milk product prepared by the compatibility of the formula provided in table 3;
in fact, the detection results of various other ceramide repair essence milk products prepared by matching specific materials and quantities in other forms according to the ceramide repair essence milk formula provided in the present embodiment and the preparation method of the ceramide repair essence milk provided in the present embodiment are substantially consistent, and those skilled in the art can obtain various other ceramide repair essence milks having substantially consistent effects according to the formula and the preparation method, so that the description is omitted and only summarized, but the embodiments summarized and described in the summary all belong to the scope of the claimed invention.
The raspberry ketone antibacterial preservative provided by the embodiment of the invention is applied to a soothing makeup-removing wet tissue, and the soothing makeup-removing wet tissue comprises the following components in parts by weight:
the raspberry ketone antibacterial preservative comprises a surfactant, a chelating agent, a skin feeling conditioning agent, a humectant, an aromatizing agent, a solubilizer, a preservative and a solvent, wherein the preservative is any one of the raspberry ketone antibacterial preservatives obtained in the first embodiment.
In this case, the soothing makeup-removing wet tissue comprises the following components in parts by weight:
2-6 parts of surfactant, 0.02-0.1 part of chelating agent, 1.5-2.5 parts of skin feel conditioner, 2-4 parts of humectant, 0.01-0.03 part of flavoring agent, 0.05-0.15 part of solubilizer, 1-1.5 parts of raspberry ketone antibacterial preservative, and the balance of solvent.
In a preferred embodiment, the soothing makeup-removing wet tissue provided in this case comprises, by weight:
4 parts of surfactant, 0.05 part of chelating agent, 1.95 parts of skin-feel conditioner, 3 parts of humectant, 0.02 part of aromatizing agent, 0.1 part of solubilizer, 1.2 parts of preservative, namely raspberry ketone bacteriostatic preservative containing 20% raspberry ketone, and the balance of solvent.
Specifically, in the soothing makeup-removing wet tissue provided by the embodiment:
the surfactant is PEG-6 caprylic/capric glyceride, the chelating agent is EDTA disodium, the skin feeling conditioner is one or more of oat kernel extract, fructo-oligosaccharide, cocamidopropyl PG-dimethyl ammonium chloride phosphate and aloe vera, the humectant is glycerin, the flavoring agent is essence, and the solubilizer is PEG-40 hydrogenated castor oil.
In this case, the preparation method of the soothing makeup-removing wet tissue comprises the following steps:
sequentially adding a surfactant, a chelating agent, a skin feeling conditioner and a humectant into a solvent, and uniformly stirring to form a phase A;
dissolving an aromatizer in a solubilizer, and uniformly stirring to form a phase B;
adding the phase B into the phase A, stirring and mixing uniformly, then adding the preservative serving as the phase C, and stirring and mixing uniformly to form a makeup removing mixed solution;
immersing the non-woven fabric in the makeup removing mixed liquid to enable the non-woven fabric to fully adsorb the makeup removing mixed liquid, taking out the non-woven fabric adsorbing the makeup removing mixed liquid, and cutting the non-woven fabric according to a set specification to obtain the makeup removing wet tissue.
As a specific embodiment, table 4 shows a makeup removing mixed solution prepared by combining the components of the makeup removing wet tissue, and a makeup removing wet tissue product prepared by the preparation method of the makeup removing wet tissue, and table 8 shows the detection results of the makeup removing wet tissue product prepared by combining the components given in table 4.
TABLE 4
The following are specifically mentioned:
table 4 shows only the combination of the make-up-relieving wet wipes provided in the present example and a make-up-relieving wet wipe product prepared by the preparation method of the make-up-relieving wet wipe provided in the present example, and table 8 shows only the detection results of the make-up-relieving wet wipe product prepared by the combination formula provided in table 4;
in fact, other specific materials and weights are matched according to the prescription of the make-up-relieving wet tissue provided by the embodiment, and other specific make-up-relieving wet tissue products prepared according to the preparation method of the make-up-relieving wet tissue provided by the embodiment have basically consistent detection results, and a person skilled in the art can obtain other various make-up-relieving wet tissues with basically consistent effects according to the prescription of the make-up-relieving wet tissue provided by the embodiment and the preparation method thereof, so that the description is not repeated and only summarized, but the implementation modes summarized and described in the summary are all within the scope of the claimed invention.
Case 3
The present case provides an application of the raspberry ketone antibacterial preservative provided in the first embodiment of the present invention in a repairing and conditioning shampoo, and the repairing and conditioning shampoo comprises:
suspending agent, chelating agent, first surfactant, thickener, pearlizing agent, lipid-forming agent, second surfactant, cation conditioner, antioxidant, aroma-forming agent, preservative and solvent, wherein:
the preservative is any one raspberry ketone antibacterial preservative obtained in the first embodiment.
In this case, the repairing and conditioning shampoo comprises the following components in parts by weight:
0.2-0.5 part by weight of a suspending agent, 0.005-0.015 part by weight of a chelating agent, 30-35 parts by weight of a first surfactant, 1.0-2.5 parts by weight of a thickening agent, 1.0-2.5 parts by weight of a pearling agent, 1.0-2.5 parts by weight of a fat-imparting agent, 10-12 parts by weight of a second surfactant, 0.3-0.6 part by weight of a cation conditioner, 3.5-5.5 parts by weight of a conditioner, 0.025-0.075 part by weight of an antioxidant, 0.2-0.6 part by weight of an aromatizing agent, 1-1.5 parts by weight of a preservative, and the balance of a solvent.
In a preferred embodiment, the repairing and conditioning shampoo provided by the example comprises the following components in parts by weight:
0.3 part by weight of suspending agent, 0.01 part by weight of chelating agent, 32 parts by weight of first surfactant, 1.5 parts by weight of thickening agent, 1.5 parts by weight of pearling agent, 1.5 parts by weight of fat-imparting agent, 6 parts by weight of second surfactant, 0.4 part by weight of cation conditioner, 4.5 parts by weight of conditioner, 0.05 part by weight of antioxidant, 0.4 part by weight of fragrance-imparting agent, 1.2 parts by weight of preservative, raspberry ketone bacteriostatic preservative containing 20% raspberry ketone, and the balance solvent.
Specifically, the repairing and conditioning shampoo provided in this example:
the suspending agent is carbomer, the chelating agent is disodium edetate, the first surfactant is a mixture formed by lauryl polyoxyethylene ether sodium sulfate and lauryl sodium sulfate in a ratio of 1: 0.88, the thickening agent is coconut oil fatty acid monoethanolamide, the pearling agent is ethylene glycol stearic acid diester, the fat-imparting agent is cetostearyl alcohol, the second surfactant is a mixture formed by ammonium xylene sulfonate, cocamidopropyl betaine and sodium lauroyl sarcosinate in a ratio of 1: 5, the cationic conditioner is cationic guar gum, the conditioner is a mixture prepared by cationic panthenol, amino silicone oil, small-particle-size emulsified silicone oil TC-1352 and large-particle-size emulsified silicone oil TC-3560 in a ratio of 1: 0.5: 1: 2, the antioxidant is vitamin E, and the fragrance-imparting agent is essence.
In this case, the preparation method of the repairing conditioning shampoo comprises the following steps:
mixing the fatting agent and a second surfactant to form a second surfactant mixture;
adding a suspending agent into a solvent, stirring uniformly, then sequentially adding a chelating agent, a first surfactant, a thickening agent and a pearling agent, heating and stirring until all solid materials are completely dissolved and uniformly dispersed to obtain a first mixed solution;
adding a second surface active mixing agent into the first mixed solution, and uniformly stirring to obtain a second mixed solution;
adding a cation conditioner into the second mixed solution, uniformly stirring, preserving heat for a period of time to fully fuse all the materials, and then carrying out first cooling to obtain a third mixed solution;
adding a conditioner and an antioxidant into the third mixed solution, and uniformly stirring to obtain a fourth mixed solution;
and cooling the fourth mixed solution for the second time, then adding the aromatizer and the preservative into the fourth mixed solution, and stirring and mixing uniformly to obtain the repairing and conditioning shampoo.
In the preparation process of the repairing and conditioning shampoo provided by the embodiment, the following control conditions are included:
when preparing the first mixed solution, heating the first mixed solution at the temperature of 70-75 ℃;
when the third mixed solution is prepared, the heat preservation temperature is 70-75 ℃, the heat preservation time is not less than 30 minutes, and the final temperature of the first cooling is controlled to be about 60 ℃;
and when the fourth mixed solution is cooled for the second time, the final temperature is controlled to be about 45 ℃.
As a specific example implementation, table 5 lists a repairing conditioning shampoo product prepared by combining the components of the repairing conditioning shampoo provided in this example and preparing the repairing conditioning shampoo provided in this example, and in table 8, the test results of the repairing conditioning shampoo product prepared by combining the components given in table 5 are given.
TABLE 5
The following are specifically mentioned:
table 5 shows only one repairing conditioning shampoo product prepared by the recipe of the repairing conditioning shampoo provided in the present case and the preparation method of the repairing conditioning shampoo provided in the present case, and table 8 shows only the detection results of the repairing conditioning shampoo product prepared by the recipe of the recipe given in table 5;
in fact, a series of repairing and conditioning shampoo products can be obtained by matching the components of the repairing and conditioning shampoo provided by the embodiment in other forms and preparing the repairing and conditioning shampoo provided by the embodiment according to the preparation method of the repairing and conditioning shampoo provided by the embodiment, and the detection shows that the results are basically consistent, and a person skilled in the art can obtain other ceramide repairing and conditioning essence emulsions with basically consistent effects according to the components and the preparation method of the repairing and conditioning shampoo provided by the embodiment, so that the description is not repeated one by one, and only the summary description is provided herein, but the summary description illustrates that the implementation modes all belong to the protection scope claimed by the invention.
Case 4
The present case provides an application of the raspberry ketone antibacterial preservative provided in the embodiment of the present invention in a glycogen skin-brightening and firming mask, which includes:
the raspberry ketone antibacterial preservative comprises a humectant, a chelating agent, a film forming agent, a suspending agent, a whitening agent, a gel agent, a penetrating agent, a pH regulator, a skin feel conditioning agent, an anti-inflammatory agent, a preservative and a solvent, wherein the preservative is any one raspberry ketone antibacterial preservative in the first embodiment.
In this case, the glycogen skin-lightening firming mask comprises the following components in parts by weight:
6-8 parts of humectant, 0.01-0.05 part of chelating agent, 0.1-0.3 part of film forming agent, 0.1-0.15 part of suspending agent, 1-3 parts of whitening agent, 0.05-0.15 part of gel, 2-4 parts of penetrating agent, 0.5-0.8 part of pH regulator, 5-8 parts of skin feel conditioner, 0.05-0.15 part of anti-inflammatory agent, 1-1.5 parts of raspberry ketone antibacterial preservative containing 20% raspberry ketone and the balance of solvent.
In a preferred embodiment, the glycogen skin-lightening and firming mask provided by the present case comprises the following components in parts by weight:
7.1 parts by weight of humectant, 0.02 part by weight of chelating agent, 0.2 part by weight of film forming agent, 0.12 part by weight of suspending agent, 2 parts by weight of whitening agent, 0.1 part by weight of gelling agent, 3 parts by weight of penetrating agent, 0.62 part by weight of pH regulator, 7.6 parts by weight of skin feel conditioner, 0.1 part by weight of anti-inflammatory agent, 1 part by weight of preservative, raspberry ketone antibacterial preservative containing 20% raspberry ketone, and the balance of solvent.
Specifically, the glycogen skin-brightening and skin-tightening mask provided by the case comprises the following components:
the skin-feel conditioning agent is a mixture prepared from 1:1.5:1 of sodium hyaluronate solution containing 1% of low molecular weight sodium hyaluronate, 1% of sodium hyaluronate solution containing 1% of medium molecular weight sodium hyaluronate and 1% of high molecular weight sodium hyaluronate, and oat kernel extract, and the anti-inflammatory agent is dipotassium glycyrrhizinate.
In this case, the preparation method of the glycogen skin-brightening and tightening mask comprises the following steps:
adding a humectant, a chelating agent, a film forming agent, a suspending agent, a whitening agent and a gel into a solvent, stirring and heating until the components are dissolved and dispersed uniformly to form a phase A, and then cooling and preserving heat; uniformly stirring the penetrating agent, the pH regulator, the skin feeling conditioner and the anti-inflammatory agent to form a phase B; and adding the phase B into the phase A, stirring and mixing uniformly, adding the preservative serving as the phase C, and stirring and mixing uniformly to obtain the glycogen skin-brightening and firming mask.
In the preparation process of the glycogen skin-brightening and firming mask, the control conditions are as follows:
when the phase A is prepared, the heating temperature is 75-85 ℃, and the cooling and heat preservation temperature is 45-55 ℃.
As a specific embodiment, table 6 shows a glycogen skin-brightening and firming mask product prepared by combining the components of the glycogen skin-brightening and firming mask provided in this embodiment and by the preparation method of the glycogen skin-brightening and firming mask provided in this embodiment, and table 8 shows the detection results of the glycogen skin-brightening and firming mask prepared by the components given in table 6.
TABLE 6
The following are specifically mentioned:
table 6 shows only a glycogen skin-brightening and firming mask product prepared by the formulation of the glycogen skin-brightening and firming mask provided in the present case and the preparation method of the glycogen skin-brightening and firming mask provided in the present case, and table 8 shows only the detection results of the glycogen skin-brightening and firming mask product prepared by the formulation provided in table 6;
in fact, different compatibility compositions are carried out according to the composition of the glycogen skin-brightening and firming mask provided by the embodiment, and various other glycogen skin-brightening and firming mask products can be obtained by preparing the glycogen skin-brightening and firming mask according to the preparation method of the glycogen skin-brightening and firming mask provided by the embodiment, because the detection results of the glycogen skin-brightening and firming mask products are basically consistent, and other ceramide repairing essence emulsions with basically consistent effects can be obtained by a person skilled in the art according to the composition and the preparation method, the description is omitted, and only summary descriptions are provided, but the implementation modes summarized and described all belong to the protection scope of the invention.
Effect test
In order to further help understanding of the technical scheme provided by the invention, four products obtained by applying the raspberry ketone antibacterial preservative provided by the first embodiment of the invention as the only antibacterial preservative are tested, so that the positive and significant beneficial effects of the raspberry ketone antibacterial preservative provided by the first embodiment of the invention are judged.
Table 8 shows the safety performance evaluation test results of four daily care products prepared by applying the raspberry ketone antibacterial preservative provided in the first embodiment of the present invention;
table 9 shows the results of testing bacteriostatic and antiseptic properties of four daily care products prepared by applying the raspberry ketone bacteriostatic and antiseptic agent provided in the first embodiment of the present invention, wherein:
sample 1 is a ceramide repair essence milk product prepared according to the formula listed in table 3 and the preparation method of the ceramide repair essence milk provided in example two case 1 of the present invention;
sample 3 is a repair conditioning shampoo product prepared according to the recipe listed in table 5 and the preparation method of the repair conditioning shampoo provided in example two case 3 of the present invention;
sample 4 is a glycogen skin-lightening firming mask product prepared according to the formula shown in table 6 and the preparation method of the glycogen skin-lightening firming mask provided in example two case 4 of the present invention;
the safety performance evaluation is carried out according to the 'cosmetic hygiene code' (2007 edition) issued by the ministry of health of the people's republic of China, in particular to a detection test of a' human skin patch test 'recorded in the' cosmetic evaluation method 'edited by the ran people's errant, wherein:
the evaluation criteria of the degree of reaction in the human skin open patch test are evaluated and judged according to the criteria listed in the following table 7;
the bacteriostatic and antiseptic performance Test refers to the Standard and Method specified in ASTM E640-06(2012) Standard Test Method for preservations in Water-cosmetic Cosmetics (Chinese meaning: Standard Test Method of antiseptic in Water-Containing Cosmetics) and European pharmacopoeia 5.1.3 (effective of antimicrobial preservation) (Chinese meaning: antibacterial preservation Effect) to perform antiseptic challenge Test, and the Test result is one of the main judgment methods for the bacteriostatic and antiseptic effects of the raspberry ketone bacteriostatic antiseptic applied to daily skin care products provided by this example.
TABLE 7
TABLE 8
TABLE 9
From tables 8 and 9, it can be seen that:
firstly, the raspberry ketone antibacterial preservative provided by the embodiment of the invention is applied to daily care products, has no obvious harm to human skin, and is safe to use;
secondly, the raspberry ketone antibacterial preservative provided by the embodiment of the invention can play a definite antibacterial and preservative role when being applied to daily care products, is effective to use and has a definite effect.
In summary, it can be seen that:
the raspberry ketone antibacterial preservative provided by the invention changes the physical properties of raspberry ketone through a unique technical means, thereby expanding the application field, so that the antibacterial preservative substance obtained from natural plants can be widely applied to daily products, has the functions of bacteriostasis and corrosion prevention, has clear, unique, creative and inspirational ideas for solving the technical problems, is novel and ingenious in the adopted technical means, is unique, and is unique, stable in product performance, convenient to use and reliable in effect, can be accepted by users easily as an antibacterial preservative taking a natural product as a main body, can reduce the addition types of the antibacterial preservative during use, is suitable for various application scenes, and meets different requirements of users, and therefore, has great popularization and application values.
During the description of the above description:
the description of the terms "present embodiment," "as shown at … …," "further improved technical solution," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention, and the schematic representation of the terms in this specification is not necessarily intended to refer to the same embodiment or example, and the particular feature, structure, material, or characteristic described, etc., may be combined or coupled in any suitable manner in any one or more embodiments or examples;
furthermore, those of ordinary skill in the art may combine or combine features of different embodiments or examples and features of different embodiments or examples described in this specification without undue conflict.
Finally, it should be noted that:
although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made on the technical solutions described in the foregoing embodiments, or some or all of the technical features of the embodiments can be equivalently replaced, and the corresponding technical solutions do not depart from the technical solutions of the embodiments of the present invention.
Claims (15)
1. A raspberry ketone antibacterial preservative is characterized by comprising:
raspberry ketone, dihydric alcohol and water-soluble solid polyhydric alcohol, and
the raspberry ketone antibacterial preservative is solid powder or particles formed by uniformly distributing raspberry ketone in water-soluble solid polyol after the raspberry ketone is dissolved and dispersed in a water solution of dihydric alcohol, wherein:
the raspberry ketone antibacterial preservative comprises, by weight, 10-30 parts of raspberry ketone, 2-15 parts of a dihydric alcohol aqueous solution and 45-65 parts of water-soluble solid polyhydric alcohol.
2. The raspberry ketone bacteriostatic preservative of claim 1, wherein:
the dihydric alcohol is one or more of 1, 3-propylene glycol, butanediol, 2, 3-butanediol, dipropylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, caprylyl glycol, methyl propylene glycol, polyethylene glycol and ethylhexyl glycerin;
the water-soluble solid polyalcohol is one or a mixture of two of sorbitol and mannitol.
3. A preparation method of a raspberry ketone antibacterial preservative is characterized by comprising the following steps:
dissolving raspberry ketone in aqueous solution of dihydric alcohol to obtain raspberry ketone dihydric alcohol solution;
crushing water-soluble solid polyol into powder, placing the powder in a container, and introducing heating and drying gas with the temperature not higher than 65 ℃ to enable the powdery water-soluble solid polyol to be in a heating boiling state;
spraying the raspberry ketone binary alcohol solution on the powdery water-soluble solid polyol in a heating boiling state by a spraying method, and drying to obtain the raspberry ketone antibacterial preservative.
4. A ceramide repair essence milk, which is characterized by comprising:
an emulsifier, a first thickener, an emollient, an antioxidant, a humectant, a first skin-feel conditioner, a second thickener, a chelating agent, a second skin-feel conditioner, a preservative, an aromatizing agent and a solvent, wherein the preservative is the raspberry ketone bacteriostatic preservative of any one of claims 1-2;
the ceramide repair essence milk comprises the following components in parts by weight based on 100 parts by weight:
10-20 parts by weight of an emulsifier, 0.5-1.5 parts by weight of a first thickener, 5-15 parts by weight of an emollient, 0.2-0.8 part by weight of an antioxidant, 5-15 parts by weight of a humectant, 0.1-0.5 part by weight of a first skin feel conditioner, 0.5-1 part by weight of a second thickener, 0.02-0.08 part by weight of a chelating agent, 0.5-2 parts by weight of a second skin feel conditioner, 1-2 parts by weight of a preservative, 0.05-0.15 part by weight of an aromatizing agent, and the balance of a solvent.
5. The ceramide repair serum as claimed in claim 4, characterized in that:
the skin-feel conditioner comprises an emulsifier, a first thickening agent, a humectant, a second thickening agent and a chelating agent, wherein the emulsifier is one or a mixture of two of olive oil polyglycerol-6 esters and sodium stearoyl lactylate, the first thickening agent is cetostearyl alcohol, the emollient is one or a mixture of more of shea butter, hydrogenated polydecene, isononyl isononanoate, polydimethylsiloxane and dimethiconol, the antioxidant is tocopherol acetate, the humectant is one or a mixture of more of polyether-26, butanediol and erythritol, the first skin-feel conditioner is one or a mixture of two of allantoin and sodium hyaluronate, the second thickening agent is one or a mixture of two of xanthan gum and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, the chelating agent is disodium EDTA, and the second skin-feel conditioner is glycerol, lauryl alcohol, sodium stearoyl lactylate, Hydrogenated lecithin, ceramide 3, phytosterol/octyldodecanol lauroyl glutamate, 1, 2-hexanediol and/or oat kernel extract, wherein the flavoring agent is daily essence, and the solvent is water.
6. A method for preparing the ceramide repair essence as claimed in claim 4, which comprises the following steps:
mixing the emulsifier, the first thickener, the emollient and the antioxidant together, stirring and heating until completely dissolving to form a phase A;
mixing the moisturizer, the first skin feel conditioner, the second thickener, the chelating agent and part of the solvent together, stirring and heating until all the materials are uniformly dispersed to form a phase B;
mixing the second skin-feel conditioner, the preservative, the aromatizing agent and part of the solvent together, stirring and heating until the materials are uniformly dispersed to form a phase C;
adding the phase A into the phase B, heating and homogenizing until complete emulsification forms an AB mixed phase, and cooling;
adding the phase C into the mixed phase AB, and uniformly stirring; wherein:
the heating temperature for preparing the phase A is 70-75 ℃, the heating temperature for preparing the phase B is 80-85 ℃, and the temperature of the AB mixed phase is kept about 45 ℃ when the phase C is added into the AB mixed phase.
7. A soothing makeup-removing wet wipe, comprising:
surfactant, chelating agent, skin feel conditioner, humectant, aromatizer, solubilizer, preservative and solvent, wherein the preservative is the raspberry ketone antibacterial preservative as claimed in any one of claims 1-2, wherein the total amount is 100 parts by weight:
2-6 parts by weight of surfactant, 0.02-0.1 part by weight of chelating agent, 1.5-2.5 parts by weight of skin-feel conditioner, 2-4 parts by weight of humectant, 0.01-0.03 part by weight of aromatizer, 0.05-0.15 part by weight of solubilizer, 1-1.5 parts by weight of preservative, and the balance of solvent.
8. A soothing makeup removing wet wipe as claimed in claim 7, wherein:
the skin-feel conditioning agent is one or a mixture of more of oat kernel extract, fructo-oligosaccharide, cocamidopropyl PG-dimethyl ammonium chloride phosphate and aloe vera, the humectant is glycerin, the flavoring agent is essence, and the solubilizer is PEG-40 hydrogenated castor oil.
9. A method of making a soothing makeup removing towelette as recited in claim 7, comprising the steps of:
adding the surfactant, the chelating agent, the skin-feel conditioner and the humectant into the solvent in sequence, and stirring uniformly in sequence to form a phase A;
dissolving the aromatizing agent in the solubilizer, and stirring uniformly to form a phase B;
adding the phase B into the phase A, stirring and mixing uniformly, then adding the preservative, and stirring and mixing uniformly to form a makeup removing mixed solution;
immersing the non-woven fabric in the makeup removing mixed liquid to enable the non-woven fabric to fully adsorb the makeup removing mixed liquid, taking out the non-woven fabric adsorbing the makeup removing mixed liquid, and cutting the non-woven fabric according to a set specification to obtain the makeup removing wet tissue.
10. A repairing and conditioning shampoo is characterized by comprising:
a suspending agent, a chelating agent, a first surfactant, a thickening agent, a pearlescing agent, a fat-endowing agent, a second surfactant, a cation conditioner, a conditioner, an antioxidant, an aromatizing agent, a preservative and a solvent, wherein the preservative is the raspberry ketone antibacterial preservative as defined in any one of claims 1-2, wherein:
the repairing and conditioning shampoo comprises the following components in parts by weight based on 100 parts by weight:
0.2-0.5 part by weight of a suspending agent, 0.005-0.015 part by weight of a chelating agent, 30-35 parts by weight of a first surfactant, 1.0-2.5 parts by weight of a thickening agent, 1.0-2.5 parts by weight of a pearling agent, 1.0-2.5 parts by weight of a fat-liquoring agent, 10-12 parts by weight of a second surfactant, 0.3-0.6 part by weight of a cation conditioner, 3.5-5.5 parts by weight of a conditioner, 0.025-0.075 part by weight of an antioxidant, 0.2-0.6 part by weight of an aromatizing agent, 1-1.5 parts by weight of a raspberry ketone antibacterial preservative, and the balance of a solvent.
11. The conditioning shampoo of claim 10 further characterized by:
the suspending agent is carbomer, the chelating agent is disodium edetate, the first surfactant is a mixture of sodium laureth sulfate and sodium dodecyl sulfate in a ratio of 1: 0.88, the thickening agent is coconut oil fatty acid monoethanolamide, the pearling agent is ethylene glycol stearic acid diester, the fatting agent is cetostearyl alcohol, the second surfactant is a mixture of ammonium xylene sulfonate, cocamidopropyl betaine and sodium lauroyl sarcosinate according to the ratio of 1: 5, the cationic conditioner is cationic guar gum, the conditioner is a mixture prepared from cationic panthenol, amino silicone oil, small-particle-size emulsified silicone oil TC-1352 and large-particle-size emulsified silicone oil TC-3560 according to the ratio of 1: 0.5: 1: 2, the antioxidant is vitamin E, and the flavoring agent is essence.
12. A method of preparing a conditioning shampoo as defined in claim 10 comprising the steps of:
mixing the fatting agent and the second surfactant to form a second surfactant mixture;
adding the suspending agent into the solvent, stirring uniformly, then sequentially adding a chelating agent, a first surfactant, a thickening agent and a pearling agent, heating and stirring until all solid materials are completely dissolved and uniformly dispersed to obtain a first mixed solution;
adding the second surfactant mixture into the first mixed solution, and uniformly stirring to obtain a second mixed solution;
adding the cationic conditioner into the second mixed solution, uniformly stirring, preserving heat for a period of time to fully fuse all materials, and then carrying out first cooling to obtain a third mixed solution;
adding the conditioner and the antioxidant into the third mixed solution, and uniformly stirring to obtain a fourth mixed solution;
cooling the fourth mixed solution for the second time, then adding the aromatizer and the preservative into the fourth mixed solution, and stirring and mixing uniformly to obtain the repairing conditioning shampoo; wherein:
the heating temperature during the preparation of the first mixed solution is 70-75 ℃, the heat preservation temperature during the preparation of the third mixed solution is 70-75 ℃ and the heat preservation time is not less than 30 minutes, the final temperature during the first cooling is controlled to be about 60 ℃, and the final temperature during the second cooling of the fourth mixed solution is controlled to be about 45 ℃.
13. A glycogen skin-lightening firming mask, comprising:
the raspberry ketone bacteriostatic and preservative comprises a humectant, a chelating agent, a film forming agent, a suspending agent, a whitening agent, a gel agent, a penetrating agent, a pH regulator, a skin feel conditioner, an anti-inflammatory agent, a preservative and a solvent, wherein the preservative is the raspberry ketone bacteriostatic and preservative as claimed in any one of claims 1-2, and the repairing and conditioning shampoo comprises the following components in parts by weight based on 100 parts:
the anti-inflammatory raspberry ketone skin conditioner comprises, by weight, 6-8 parts of a humectant, 0.01-0.05 part of a chelating agent, 0.1-0.3 part of a film forming agent, 0.1-0.15 part of a suspending agent, 1-3 parts of a whitening agent, 0.05-0.15 part of a gelling agent, 2-4 parts of a penetrating agent, 0.5-0.8 part of a pH regulator, 5-8 parts of a skin conditioning agent, 0.05-0.15 part of an anti-inflammatory agent, 1-1.5 parts of a raspberry ketone antibacterial preservative and the balance of a solvent.
14. The glycogen skin-lightening mask of claim 13, wherein:
the skin feeling conditioner is a mixture prepared from 1:1.5:1 of sodium hyaluronate containing 1% of low molecular weight sodium hyaluronate, 1% of sodium hyaluronate containing 1% of medium molecular weight sodium hyaluronate and 1% of sodium hyaluronate containing 1% of high molecular weight sodium hyaluronate, and an oat kernel extract, and the anti-inflammatory agent is dipotassium glycyrrhizinate.
15. The method of preparing the glycogen skin-lightening firming mask of claim 13, comprising the steps of:
adding the humectant, the chelating agent, the film forming agent, the suspending agent, the whitening agent and the gel into the solvent, stirring and heating until the components are dissolved and dispersed uniformly to form a phase A, and then cooling and preserving heat;
stirring the penetrant, the pH regulator, the skin-feel conditioner and the anti-inflammatory agent uniformly to form a phase B;
adding the phase B into the phase A, stirring and mixing uniformly, then adding the preservative, and stirring and mixing uniformly to obtain the glycogen skin-brightening and tightening mask; wherein:
the heating temperature for preparing the phase A is 75-85 ℃, and the cooling and heat preservation temperature is 45-55 ℃.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114983834A (en) * | 2022-05-25 | 2022-09-02 | 广州环亚化妆品科技股份有限公司 | Wet tissue without preservative and preparation method and application thereof |
| CN115463043A (en) * | 2022-08-25 | 2022-12-13 | 克劳丽化妆品股份有限公司 | Oral care composition and mouthwash |
| WO2023122003A1 (en) * | 2021-12-21 | 2023-06-29 | Isp Investments Llc | An antimicrobial liquid composition, process for preparing the same and method of use thereof |
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2021
- 2021-07-06 CN CN202110772232.9A patent/CN113476322A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023122003A1 (en) * | 2021-12-21 | 2023-06-29 | Isp Investments Llc | An antimicrobial liquid composition, process for preparing the same and method of use thereof |
| CN114983834A (en) * | 2022-05-25 | 2022-09-02 | 广州环亚化妆品科技股份有限公司 | Wet tissue without preservative and preparation method and application thereof |
| CN114983834B (en) * | 2022-05-25 | 2023-09-05 | 广州环亚化妆品科技股份有限公司 | Preservative-free wet tissue and preparation method and application thereof |
| CN115463043A (en) * | 2022-08-25 | 2022-12-13 | 克劳丽化妆品股份有限公司 | Oral care composition and mouthwash |
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