CN115463043A - Oral care composition and mouthwash - Google Patents
Oral care composition and mouthwash Download PDFInfo
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- CN115463043A CN115463043A CN202211026294.6A CN202211026294A CN115463043A CN 115463043 A CN115463043 A CN 115463043A CN 202211026294 A CN202211026294 A CN 202211026294A CN 115463043 A CN115463043 A CN 115463043A
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- Prior art keywords
- ether
- vinyl
- oral care
- zinc
- care composition
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- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 239000002324 mouth wash Substances 0.000 title claims abstract description 33
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 31
- 229920001577 copolymer Polymers 0.000 claims abstract description 45
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 25
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract description 17
- 125000005670 ethenylalkyl group Chemical group 0.000 claims abstract description 16
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims abstract description 13
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- 229940034610 toothpaste Drugs 0.000 claims abstract description 6
- 239000000606 toothpaste Substances 0.000 claims abstract description 6
- 229940041678 oral spray Drugs 0.000 claims abstract description 4
- 239000000668 oral spray Substances 0.000 claims abstract description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 33
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 22
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- WSELJKAMVUHMJP-PUZYILPLSA-N (2s,3r,4s,5r)-2,3-dichloro-2,3,4,5,6-pentahydroxyhexanoyl chloride Chemical compound OC[C@@H](O)[C@H](O)[C@@](O)(Cl)[C@](O)(Cl)C(Cl)=O WSELJKAMVUHMJP-PUZYILPLSA-N 0.000 claims description 11
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 11
- 235000005074 zinc chloride Nutrition 0.000 claims description 11
- 239000011592 zinc chloride Substances 0.000 claims description 11
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 claims description 10
- 239000004359 castor oil Substances 0.000 claims description 9
- 235000019438 castor oil Nutrition 0.000 claims description 9
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 9
- 229920001983 poloxamer Polymers 0.000 claims description 9
- 229960000502 poloxamer Drugs 0.000 claims description 9
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 8
- 235000006076 zinc citrate Nutrition 0.000 claims description 8
- 239000011746 zinc citrate Substances 0.000 claims description 8
- 229940068475 zinc citrate Drugs 0.000 claims description 8
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 claims description 8
- NPFYZDNDJHZQKY-UHFFFAOYSA-N 4-Hydroxybenzophenone Chemical compound C1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 NPFYZDNDJHZQKY-UHFFFAOYSA-N 0.000 claims description 6
- RJYQSBZWJQBWBT-UHFFFAOYSA-N 1,7-bis(4-hydroxyphenyl)heptan-4-one Chemical compound C1=CC(O)=CC=C1CCCC(=O)CCCC1=CC=C(O)C=C1 RJYQSBZWJQBWBT-UHFFFAOYSA-N 0.000 claims description 5
- HMBNQNDUEFFFNZ-UHFFFAOYSA-N 4-ethenoxybutan-1-ol Chemical compound OCCCCOC=C HMBNQNDUEFFFNZ-UHFFFAOYSA-N 0.000 claims description 5
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 5
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 5
- 235000011478 zinc gluconate Nutrition 0.000 claims description 5
- 239000011670 zinc gluconate Substances 0.000 claims description 5
- 229960000306 zinc gluconate Drugs 0.000 claims description 5
- VUIWJRYTWUGOOF-UHFFFAOYSA-N 2-ethenoxyethanol Chemical compound OCCOC=C VUIWJRYTWUGOOF-UHFFFAOYSA-N 0.000 claims description 4
- VGIYPVFBQRUBDD-UHFFFAOYSA-N ethenoxycyclohexane Chemical compound C=COC1CCCCC1 VGIYPVFBQRUBDD-UHFFFAOYSA-N 0.000 claims description 4
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 4
- 229960001763 zinc sulfate Drugs 0.000 claims description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 4
- CYIGRWUIQAVBFG-UHFFFAOYSA-N 1,2-bis(2-ethenoxyethoxy)ethane Chemical compound C=COCCOCCOCCOC=C CYIGRWUIQAVBFG-UHFFFAOYSA-N 0.000 claims description 3
- CMTIUBRAGNDCRZ-UHFFFAOYSA-N 1-(2-hydroxyethoxy)but-3-en-2-ol Chemical compound C(=C)C(COCCO)O CMTIUBRAGNDCRZ-UHFFFAOYSA-N 0.000 claims description 3
- SAMJGBVVQUEMGC-UHFFFAOYSA-N 1-ethenoxy-2-(2-ethenoxyethoxy)ethane Chemical compound C=COCCOCCOC=C SAMJGBVVQUEMGC-UHFFFAOYSA-N 0.000 claims description 3
- LAYAKLSFVAPMEL-UHFFFAOYSA-N 1-ethenoxydodecane Chemical compound CCCCCCCCCCCCOC=C LAYAKLSFVAPMEL-UHFFFAOYSA-N 0.000 claims description 3
- XXCVIFJHBFNFBO-UHFFFAOYSA-N 1-ethenoxyoctane Chemical compound CCCCCCCCOC=C XXCVIFJHBFNFBO-UHFFFAOYSA-N 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 3
- 229960001939 zinc chloride Drugs 0.000 claims description 3
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 3
- 229910000165 zinc phosphate Inorganic materials 0.000 claims description 3
- 229940077935 zinc phosphate Drugs 0.000 claims description 3
- OWVLYQRCCIEOPF-QHTZZOMLSA-L zinc;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Zn+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 OWVLYQRCCIEOPF-QHTZZOMLSA-L 0.000 claims description 3
- DSSAWHFZNWVJEC-UHFFFAOYSA-N 3-(ethenoxymethyl)heptane Chemical compound CCCCC(CC)COC=C DSSAWHFZNWVJEC-UHFFFAOYSA-N 0.000 claims description 2
- 239000012965 benzophenone Substances 0.000 claims description 2
- NWRQECKGIJYTPP-UHFFFAOYSA-N 2,2-bis(ethenyl)oxolane Chemical compound C(=C)C1(OCCC1)C=C NWRQECKGIJYTPP-UHFFFAOYSA-N 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 11
- 150000003751 zinc Chemical class 0.000 abstract description 9
- 235000019640 taste Nutrition 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 6
- 239000011701 zinc Substances 0.000 abstract description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 5
- 229910052725 zinc Inorganic materials 0.000 abstract description 5
- 206010013911 Dysgeusia Diseases 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 3
- 235000019658 bitter taste Nutrition 0.000 abstract description 2
- 239000002244 precipitate Substances 0.000 abstract description 2
- 235000019643 salty taste Nutrition 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 23
- 238000012360 testing method Methods 0.000 description 19
- 238000002156 mixing Methods 0.000 description 18
- 206010006326 Breath odour Diseases 0.000 description 16
- 208000032139 Halitosis Diseases 0.000 description 16
- 238000006243 chemical reaction Methods 0.000 description 15
- 238000003756 stirring Methods 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 12
- 238000001556 precipitation Methods 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 238000013112 stability test Methods 0.000 description 5
- PARHMNZPOUVEIQ-UHFFFAOYSA-N 1-(4-hydroxyphenyl)butan-2-one Chemical compound CCC(=O)CC1=CC=C(O)C=C1 PARHMNZPOUVEIQ-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000007800 oxidant agent Substances 0.000 description 4
- -1 p-hydroxybenzoic acid ethanone Chemical compound 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 230000001590 oxidative effect Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- 208000034619 Gingival inflammation Diseases 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229960001173 oxybenzone Drugs 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 229920001992 poloxamer 407 Polymers 0.000 description 2
- 229940044476 poloxamer 407 Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229960000834 vinyl ether Drugs 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- KIOBFQQEFSRYOV-UHFFFAOYSA-N 4-ethenylhex-5-ene-1,4-diol Chemical compound C(=C)C(CCCO)(O)C=C KIOBFQQEFSRYOV-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000234282 Allium Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000021438 curry Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000011841 epidemiological investigation Methods 0.000 description 1
- 229940052303 ethers for general anesthesia Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 230000002414 glycolytic effect Effects 0.000 description 1
- 239000008266 hair spray Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000021268 hot food Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- NJGBTKGETPDVIK-UHFFFAOYSA-N raspberry ketone Chemical compound CC(=O)CCC1=CC=C(O)C=C1 NJGBTKGETPDVIK-UHFFFAOYSA-N 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 235000021259 spicy food Nutrition 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Abstract
The invention provides an oral care composition and mouthwash, belonging to the technical field of oral care and comprising the following components: a zinc ion source, a copolymer formed from a vinyl alkyl ether and maleic anhydride, and a p-hydroxyalkylphenone compound; the weight ratio of the zinc ion source, the copolymer formed by vinyl alkyl ether and maleic anhydride and the p-hydroxyalkylphenone compounds is 0.01-1. The product form of the oral care composition is a toothpaste, a mouthwash or an oral spray. The oral care composition prepared by the invention is not turbid and does not precipitate at low temperature, room temperature and high temperature, the stability of the zinc-containing oral care substance is improved, the oral care composition has the effects of refreshing breath and preventing or reducing dental plaque generation, and simultaneously, the salty or bitter taste brought by zinc salt is reduced or improved, the bad taste of the zinc salt can be covered, and the product has good taste.
Description
Technical Field
The invention relates to the technical field of oral care, in particular to an oral care composition and mouthwash.
Background
Breath is also called halitosis, which is a symptom of odor emitted during breathing or mouth opening. Halitosis is quite common among adults, and epidemiological investigations have shown that the incidence of halitosis is high, with 24% of adults over 30 years of age in Japan complaints of halitosis symptoms; in the united states, 92% of dentists encounter patients seeking treatment for halitosis, and nearly 50% of dentists encounter more than 6 patients with halitosis per week.
At present, the commonly reported effective substances for improving halitosis are mainly broad-spectrum antibacterial agents, such as chlorhexidine, cetylpyridinium chloride, triclosan and the like. However, long-term use of these broad-spectrum antibacterial agents is likely to cause drug resistance and other side effects of oral bacteria, such as staining of teeth and mucous membranes by long-term use of chlorhexidine, and change of the sexual taste after gargling. Besides broad-spectrum antibacterial agents, essential oils, oxidants, metal ions, and the like are used in many cases. Essential oils have a good inhibitory effect on breath-producing bacteria, but are less stable in oral care products and are not easily stored stably for a long period of time. The oxidant mainly comprises chlorine dioxide and hydrogen peroxide, and can directly oxidize Volatile Sulfides (VSCs) to form tasteless products so as to inhibit halitosis, but the oxidant has an irritation effect on oral mucosa, and adverse reactions can be caused after the oxidant is used by people with sensitive oral cavity.
Metal ions are functional substances which have been receiving attention from researchers in recent years, and have a certain degree of inhibitory effect on oral bacteria. Among a plurality of metal ions, zinc has small molecular weight, small activity, little tooth coloring, light metal taste and ideal action effect, thereby having good application prospect. The mechanism of inhibiting halitosis by zinc ions is as follows: first, zn 2+ Can generate affinity with sulfur, oxidize the sulfhydryl groups in the VSCs or the substances capable of generating the VSCs, and make the VSCs into nonvolatile products. Zinc ion can be absorbed by newly secreting Ca in saliva 2+ The ion replacement is carried out, and the ion replacement is combined with substances such as carboxyl, phosphate radical and the like, so that the ion replacement can be retained in the oral cavity for a long time, slow and lasting release is obtained, and the function of inhibiting the VSCs is continuously exerted.Its second, zn 2+ Can oxidize sulfydryl in glycolytic enzyme, so as to reduce the metabolic activity of bacteria in bacterial plaque, and achieve the effect of inhibiting bacterial plaque. But containing Zn 2+ The mouthwash is easy to hydrolyze, easily influences surfactant micelles, and easily generates unstable phenomena such as turbidity, precipitation and the like after being placed for a long time. Therefore, there is a need for improvement of the existing halitosis products, which can improve the halitosis while improving the taste and stability of the products.
Disclosure of Invention
The invention aims to provide an oral care composition and a mouth wash, wherein the oral care composition improves the stability of a zinc-containing dentifrice, covers the bad taste of zinc salts, and has the effects of refreshing breath and preventing or reducing dental plaque generation.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides an oral care composition, which comprises the following components: a zinc ion source, a copolymer formed from a vinyl alkyl ether and maleic anhydride, and a p-hydroxyalkylphenone compound; the weight ratio of the zinc ion source, the copolymer formed by vinyl alkyl ether and maleic anhydride and the p-hydroxyalkylphenone compounds is 0.01-2.
Further, the zinc ion source is one or more of zinc citrate, zinc chloride, zinc sulfate, zinc phosphate, zinc nitrate, zinc gluconate and zinc PCA.
Further, the vinyl alkyl ether is one or more of vinyl methyl ether, vinyl ethyl ether, vinyl cyclohexyl ether, vinyl glycol ether, vinyl diglycol ether, 4-hydroxybutyl vinyl ether, diethylene glycol divinyl ether, divinyl-1, 4-butylene glycol ether, 2-ethylhexyl vinyl ether, triethylene glycol divinyl ether, vinyl dodecyl ether and vinyl n-octyl ether.
Furthermore, the p-hydroxyalkyl phenone compound is one or more of p-hydroxyacetophenone, p-hydroxyphenylethyl methyl ketone, p-hydroxybenzophenone, p-hydroxybenzoic acid ethanone and p-hydroxy-butanone.
Further, the oral care composition also comprises a carrier, wherein the carrier is one or more of water, a nonionic surfactant, a humectant, a sweetener, citric acid, a solubilizer, essence and an abrasive.
Further, the product form of the oral care composition is a toothpaste, a mouthwash or an oral spray.
The invention also provides mouthwash, which comprises the following components in parts by weight: 1 to 5 parts of oral care composition, 1 to 10 parts of glycerol, 1 to 10 parts of propylene glycol, 0.01 to 0.1 part of trichlorogalactose, 0.1 to 5 parts of poloxamer, 0.1 to 2 parts of PEG-40 hydrogenated castor oil, 0.01 to 0.5 part of essence, 0.005 to 0.100 part of citric acid and 70 to 90 parts of water.
Compared with the prior art, the invention has the beneficial effects that:
the invention utilizes the interaction of zinc ion source, copolymer formed by vinyl alkyl ether and maleic anhydride and p-hydroxyalkyl benzophenone compound, and the copolymer formed by vinyl alkyl ether and maleic anhydride and surfactant are used, so that the stability of zinc salt can be improved, and the oral astringent feeling brought by zinc ion can be improved.
The oral care composition provided by the invention does not get turbid or precipitate at low temperature (-18 ℃), room temperature (25 ℃) and high temperature (50 ℃), and improves the stability of the zinc-containing dentifrice. The toothpaste also has the effects of removing oral peculiar smell, refreshing breath, preventing or reducing dental plaque generation, providing an oral hygiene environment, further avoiding the occurrence of gingival inflammation and slowing down the gingival inflammation degree, and finally improving the health condition of the oral cavity.
The oral care composition can cover the bad taste of the zinc salt, reduce or improve the salty or bitter taste caused by the zinc salt, and ensure that the product has good taste.
Detailed Description
The invention provides an oral care composition, which comprises the following components: zinc ion sources, copolymers formed from vinyl alkyl ethers and maleic anhydride, and p-hydroxyalkylphenones.
In the present invention, the weight ratio of the zinc ion source, the copolymer of a vinyl alkyl ether and maleic anhydride, and the p-hydroxyalkylphenone-based compound is from 0.01 to 1.
In the present invention, the preparation of the oral care composition comprises a zinc ion source which is one or more of zinc citrate, zinc chloride, zinc sulfate, zinc phosphate, zinc nitrate, zinc gluconate and zinc PCA, preferably zinc citrate, zinc chloride, zinc nitrate and zinc gluconate, and more preferably zinc chloride and zinc citrate.
In the present invention, the preparation of the oral care composition comprises a copolymer of vinyl alkyl ether and maleic anhydride, wherein the vinyl alkyl ether is one or more of vinyl methyl ether, vinyl ethyl ether, vinyl cyclohexyl ether, vinyl glycol ether, vinyl diglycol ether, 4-hydroxybutyl vinyl ether, diethylene glycol divinyl ether, divinyl-1, 4-butylene glycol ether, 2-ethylhexyl vinyl ether, triethylene glycol divinyl ether, vinyl dodecyl ether and vinyl n-octyl ether, preferably vinyl methyl ether, vinyl ethyl ether, vinyl cyclohexyl ether, vinyl diglycol ether, 4-hydroxybutyl vinyl ether and 2-ethylhexyl vinyl ether, and further preferably vinyl methyl ether, vinyl ethyl ether and 4-hydroxybutyl vinyl ether.
In the present invention, the oral care composition is prepared by including a copolymer of vinyl alkyl ether and maleic anhydride, which is one or more of vinyl methyl ether-maleic anhydride copolymer, vinyl ethyl ether-maleic anhydride copolymer, vinyl cyclohexyl ether-maleic anhydride copolymer, vinyl glycol ether-maleic anhydride copolymer, vinyl diethylene glycol ether-maleic anhydride copolymer, 4-hydroxybutyl vinyl ether-maleic anhydride copolymer, diethylene glycol divinyl ether-maleic anhydride copolymer, divinyl-1, 4-butylene glycol ether-maleic anhydride copolymer, 2-ethylhexyl vinyl ether-maleic anhydride copolymer, triethylene glycol divinyl ether-maleic anhydride copolymer, vinyl dodecyl ether-maleic anhydride copolymer, and vinyl n-octyl ether-maleic anhydride copolymer, preferably vinyl methyl ether-maleic anhydride copolymer, vinyl ethyl ether-maleic anhydride copolymer, vinyl cyclohexyl ether-maleic anhydride copolymer, vinyl diethylene glycol ether-maleic anhydride copolymer, 4-hydroxybutyl vinyl ether-maleic anhydride copolymer, and 2-ethylhexyl vinyl ether-maleic anhydride copolymer, and further preferably vinyl methyl ether-maleic anhydride copolymer, vinyl ethyl ether-maleic anhydride copolymer, and 4-hydroxybutyl vinyl ether-maleic anhydride copolymer.
In the present invention, the preparation of the oral care composition comprises p-hydroxyalkyl phenone compounds which are one or more of p-hydroxyacetophenone, p-hydroxyphenylethylmethyl ketone, p-hydroxycetone, p-hydroxybenzoic acid ketone and p-hydroxy-oxybenzone, preferably p-hydroxyacetophenone, p-hydroxyphenylethylmethyl ketone and p-hydroxybenzoic acid ketone, and more preferably p-hydroxyphenylethylmethyl ketone and p-oxybenzone.
In the invention, the oral care composition further comprises a carrier, wherein the carrier is one or more of water, a nonionic surfactant, a humectant, a sweetener, citric acid, a solubilizer, an essence and an abrasive, and preferably water, the humectant, the sweetener, citric acid, the solubilizer and the essence.
In the present invention, the product form of the oral care composition is a toothpaste, a mouthwash or an oral spray.
The invention also provides mouthwash, which comprises the following components in parts by weight: 1 to 5 parts of oral care composition, 1 to 10 parts of glycerol, 1 to 10 parts of propylene glycol, 0.01 to 0.1 part of trichlorogalactose, 0.1 to 5 parts of poloxamer, 0.1 to 2 parts of PEG-40 hydrogenated castor oil, 0.01 to 0.5 part of essence, 0.005 to 0.100 part of citric acid and 70 to 90 parts of water.
In the invention, the components for preparing the mouthwash comprise 1 to 5 parts by weight of the oral care composition, preferably 1.5 to 4.5 parts by weight, and more preferably 2 to 4 parts by weight.
In the invention, the components for preparing the mouthwash comprise 1-10 parts of glycerol, preferably 2-8 parts of glycerol, and more preferably 4-6 parts of glycerol.
In the invention, the components for preparing the mouthwash comprise 1 to 10 parts of propylene glycol, preferably 2 to 8 parts of propylene glycol, and more preferably 3 to 6 parts of propylene glycol.
In the invention, the components for preparing the mouthwash comprise 0.01 to 0.1 part of trichlorogalactose, preferably 0.02 to 0.05 part of trichlorogalactose, and more preferably 0.03 to 0.04 part of trichlorogalactose.
In the invention, the components for preparing the mouthwash comprise 0.1-5 parts of poloxamer, preferably 0.5-4 parts of poloxamer, and further preferably 0.8-3 parts of poloxamer.
In the invention, the components for preparing the mouthwash comprise 0.1-2 parts of PEG-40 hydrogenated castor oil, preferably 0.2-1.5 parts, and more preferably 0.5-1 part by weight.
In the invention, the components for preparing the mouthwash comprise 0.01 to 0.5 part of essence, preferably 0.05 to 0.3 part, and further preferably 0.1 to 0.2 part by weight.
In the invention, the components for preparing the mouthwash comprise 0.005 to 0.100 part of citric acid, preferably 0.010 to 0.090 part, and more preferably 0.015 to 0.080 part by weight.
In the invention, the components for preparing the mouthwash comprise 70-90 parts of water, preferably 73-88 parts of water, and more preferably 75-85 parts of water.
In the invention, the preparation method of the mouthwash comprises the following steps:
(1) Adding water, glycerol, trichlorogalactose and poloxamer into a reaction pot, and mixing;
(2) Adding a copolymer formed by vinyl alkyl ether and maleic anhydride into a reaction pot, and mixing;
(3) Adding a zinc ion source into a reaction kettle, and mixing;
(4) Mixing propylene glycol and p-hydroxy alkyl benzophenone compounds, heating to dissolve, stirring uniformly, adding into a reaction kettle, and mixing.
(5) Adding PEG-40 hydrogenated castor oil and essence into reaction kettle, and mixing.
(6) Citric acid was used to adjust the pH.
In the present invention, the temperature of heating in step (4) of the preparation method of the mouthwash is 50 to 70 ℃, preferably 55 to 65 ℃, and more preferably 58 to 62 ℃.
In the present invention, the pH value adjusted in step (6) of the method for preparing a mouthwash is 5.0 to 7.5, preferably 5.5 to 7.0, and more preferably 5.8 to 6.5.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
This example provides an oral care composition comprising 0.6g of zinc chloride, 2g of vinyl methyl ether-maleic anhydride copolymer, and 0.4g of p-hydroxy butanone.
Example 2
This example provides an oral care composition comprising zinc sulfate 0.3g, vinylcyclohexane-maleic anhydride copolymer 1g, and p-hydroxyphenylethylmethylketone 0.6g.
Example 3
This example provides an oral care composition comprising zinc gluconate 0.2g, divinyl-1, 4-butylene glycol-maleic anhydride copolymer 3g, and acetophenon p-hydroxybenzoate 0.5g.
Example 4
This example provides an oral care composition comprising zinc citrate 0.5g, zinc chloride 0.2g, vinyl dodecyl ether-maleic anhydride copolymer 5g, and p-hydroxybenzophenone 0.6g.
Example 5
The embodiment provides mouthwash, which comprises 0.2g of zinc chloride, 2g of vinyl methyl ether-maleic anhydride copolymer, 0.5g of p-hydroxy-phenyl butanone, 10g of glycerol, 5g of propylene glycol, 0.03g of trichlorogalactose, 0.8g of poloxamer, 0.5g of PEG-40 hydrogenated castor oil, 0.1g of essence, 0.015g of citric acid and 80.855g of water.
The preparation method of the mouthwash comprises the following steps:
1. sequentially adding water, glycerol, trichlorogalactose and poloxamer 407 into a reaction pot, and uniformly mixing and stirring;
2. adding vinyl methyl ether-maleic anhydride copolymer into a reaction kettle, and uniformly mixing and stirring;
3. adding zinc chloride into a reaction kettle, and uniformly mixing and stirring;
4. mixing propylene glycol and p-hydroxy butanone, heating to 60 ℃, mixing and stirring to completely dissolve the p-hydroxy butanone, then adding the mixture into a reaction pot, and stirring uniformly;
5. uniformly mixing PEG-40 hydrogenated castor oil and essence, adding into a reaction kettle, and stirring;
6. citric acid was used to adjust the pH to 6.2.
Example 6
The embodiment provides mouthwash, which comprises 0.3g of zinc citrate, 3g of vinyl ethyl ether-maleic anhydride copolymer, 0.5g of p-hydroxyacetophenone, 10g of glycerol, 5g of propylene glycol, 0.04g of trichlorogalactose, 1g of poloxamer, 0.8g of PEG-40 hydrogenated castor oil, 0.2g of essence, 0.02g of citric acid and 79.14g of water.
The preparation method of the mouthwash comprises the following steps:
1. sequentially adding water, glycerol, trichlorogalactose and poloxamer 407 into a reaction pot, and uniformly mixing and stirring;
2. adding the vinyl ether-maleic anhydride copolymer into a reaction kettle, and uniformly mixing and stirring;
3. adding zinc citrate into a reaction kettle, and mixing and stirring uniformly;
4. mixing propylene glycol and p-hydroxyacetophenone, heating to 60 ℃, mixing and stirring to completely dissolve the p-hydroxyacetophenone, then adding the mixture into a reaction kettle, and stirring uniformly;
5. uniformly mixing PEG-40 hydrogenated castor oil and essence, adding into a reaction kettle, and stirring;
6. citric acid was used to adjust the pH to 6.0.
Comparative example 1
Compared with the embodiment 5, the comparison example does not add vinyl methyl ether-maleic anhydride copolymer, and the rest raw materials, the use amount and the preparation method are the same.
Comparative example 2
Compared with the embodiment 5, the comparative example does not add zinc chloride, and the rest raw materials, the use amount and the preparation method are the same.
Comparative example 3
Compared with the example 5, the comparative example does not add p-hydroxy-phenyl butanone, and the other raw materials, the dosage and the preparation method are the same.
Comparative example 4
In the comparative example, compared with example 5, the vinyl methyl ether-maleic anhydride copolymer and the p-hydroxy-phenyl butanone are not added, and the other raw materials, the dosage and the preparation method are the same.
Comparative example 5
In the comparative example, compared with example 5, zinc chloride, vinyl methyl ether-maleic anhydride copolymer and p-hydroxy-phenyl butanone are not added, and the rest raw materials, the use amount and the preparation method are the same.
Examples of the experiments
The above examples 5 to 6 and comparative examples 1 to 5 were evaluated for stability, halitosis-removal and mouth-feel.
1. Stability test
The experimental product and the reference product after standing for 24 hours are respectively put into a 100mL transparent plastic bottle, and are respectively stood for 3 months at the temperature of minus 18 ℃, 25 ℃ and 50 ℃, and whether substances are separated out or not is observed, and the results are shown in Table 1.
TABLE 1 stability testing
| Examples | -18℃ | 25℃ | 50℃ | The result of the judgment |
| Example 5 | Colorless and transparent | Colorless and transparent | Colorless and transparent | By passing |
| Example 6 | Colorless and transparent | Colorless and transparent | Colorless and transparent | By passing |
| Comparative example 1 | Precipitation out of | Precipitation out | Turbidity by precipitation | Do not pass through |
| Comparative example 2 | Colorless and transparent | Colorless and transparent | Colorless and transparent | By passing |
| Comparative example 3 | Colorless and transparent | Colorless and transparent | Colorless and transparent | By passing |
| Comparative example 4 | Precipitation out of | Precipitation out of | Turbidity by precipitation | Do not pass through |
| Comparative example 5 | Colorless and transparent | Colorless and transparent | Colorless and transparent | By passing |
As is clear from the stability test data in Table 1, the samples of examples 5 and 6 did not show turbidity, precipitation, etc., and passed the stability test at-18 deg.C, 25 deg.C, and 50 deg.C for 3 months. Comparative examples 1 and 4, which contained a zinc ion source, failed the stability test. The oral care composition has better stability.
2. Halitosis-removing efficacy and mouth feel test
The mouthwashes of examples 5 to 6, comparative example 2, comparative example 3, and comparative example 5 that passed the stability test described above (which did not participate in the halitosis-removing efficacy test because of their poor stability in comparative example 1 and comparative example 4) were stored at room temperature, and after three months of storage from the date of production, the mouth odor analysis and the mouth feel test were performed.
The test is carried out by selecting 250 patients with halitosis as chief complaint symptom, randomly dividing the patients into five groups, wherein each group comprises 50 patients, 130 male patients, 120 female patients, 60 with the largest age and 20 with the smallest age. The test day before the test requires that the subject should not eat spicy and hot foods, the test day should not eat foods such as eggs, onions, garlic, sugar, curry, etc., the test day should not use oral cleaning products such as toothpaste and mouthwash, and the test day should not use perfumes, hair spray, lipstick, etc., which may affect the test result.
The test method comprises the following steps:
(1) The baseline VSCs of the subjects were measured using an Oral analyzer Oral Chroma (abimetical corporation).
(2) After 10min, the subject rinses with the test sample for 1-2min, and the level of VSCs in the exhaled breath of the subject is tested, and the group of test products has a breath freshening effect when the total number of VSCs is below the decision threshold (VSCs threshold 176 ppb). Meanwhile, the evaluator performs human body sensory evaluation on the breath and gives an evaluation result.
And (3) evaluating an instrument:
TABLE 2 results of instrumental testing
Human body evaluation:
TABLE 3 evaluation results of human body
And (3) testing results: as can be seen from the test data in tables 2 and 3, the Oral Chroma test results and the human body evaluation results show consistency, and the mouth rinses of example 5 and example 6 of the invention have better instant halitosis removing efficacy, and the breath freshening is still maintained at more than 80% for 3 hours, which is obviously higher than that of the comparative examples 2, 3 and 5.
Table 4 taste testing results
And (3) testing results: as can be seen from the test data in table 4, the oral care composition of the present invention has a higher lubricating feeling, and has a higher astringent feeling and bitter feeling compared to comparative example 1, so that the oral care composition of the present invention has a breath freshening effect, can mask the bad taste of the zinc salt, and can reduce or improve the salty or bitter feeling caused by the zinc salt, so as to provide a good taste.
As can be seen from the above examples, the present invention provides an oral care composition and a mouthwash, which improve the stability of zinc-containing dentifrices, mask the unpleasant taste of zinc salts, and have the effects of freshening breath, preventing or reducing plaque formation.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (7)
1. An oral care composition comprising the following components: a zinc ion source, a copolymer formed from a vinyl alkyl ether and maleic anhydride, and a p-hydroxyalkylphenone compound; the weight ratio of the zinc ion source, the copolymer formed by vinyl alkyl ether and maleic anhydride and p-hydroxy alkyl benzophenone compound is 0.01-1.
2. The oral care composition of claim 1, wherein the zinc ion source is one or more of zinc citrate, zinc chloride, zinc sulfate, zinc phosphate, zinc nitrate, zinc gluconate, and zinc PCA.
3. The oral care composition of claim 1, wherein the vinyl alkyl ether is one or more of vinyl methyl ether, vinyl ethyl ether, vinyl cyclohexyl ether, vinyl glycol ether, vinyl diethylene glycol ether, 4-hydroxybutyl vinyl ether, diethylene glycol divinyl ether, divinyl-1, 4-butylene ether, 2-ethylhexyl vinyl ether, triethylene glycol divinyl ether, vinyl dodecyl ether, vinyl n-octyl ether.
4. The oral care composition according to claim 1, wherein the p-hydroxyalkylphenone compounds are one or more of p-hydroxyacetophenone, p-hydroxyphenylethylmethyl ketone, p-hydroxybenzophenone, p-hydroxyacetophenone, and p-hydroxy-butanone.
5. The oral care composition according to claim 1, further comprising a carrier, wherein the carrier is one or more of water, a nonionic surfactant, a humectant, a sweetener, citric acid, a solubilizer, a flavor and an abrasive.
6. The oral care composition according to any one of claims 1 to 6, wherein the product form of the oral care composition is a toothpaste, a mouthwash or an oral spray.
7. The mouthwash is characterized by comprising the following components in parts by weight: 1-5 parts of oral care composition as defined in any one of claims 1-7, 1-10 parts of glycerol, 1-10 parts of propylene glycol, 0.01-0.1 part of trichlorogalactose, 0.1-5 parts of poloxamer, 0.1-2 parts of PEG-40 hydrogenated castor oil, 0.01-0.5 part of essence, 0.005-0.100 part of citric acid and 70-90 parts of water.
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