CN109893463A - A kind of whitening peptide composition and its preparation and use - Google Patents
A kind of whitening peptide composition and its preparation and use Download PDFInfo
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- CN109893463A CN109893463A CN201910334004.6A CN201910334004A CN109893463A CN 109893463 A CN109893463 A CN 109893463A CN 201910334004 A CN201910334004 A CN 201910334004A CN 109893463 A CN109893463 A CN 109893463A
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Abstract
The invention belongs to cosmetic fields, and in particular to a kind of whitening peptide composition and its preparation and use.The peptide composition includes following component by mass percentage: glutathione 0.1%-0.5%, -5 1%-5% of palmityl tripeptides, -1 0.1%-0.5% of nonapeptide, carnosine 0.05%-0.2%.Tests prove that whitening peptide composition of the present invention can effectively inhibit the activity of tyrosinase, the generation of melanin is reduced, bright color is reached, is lightened the stain, improvement skin is dark yellow, brightens the purpose of skin quality.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of whitening peptide composition, the invention further relates to whitenings
The preparation method and purposes of peptide composition.
Background technique
The sense of loving to make up and wearing beautiful clothes that today's society masses pursue high face value more and more highlights, and a ugly white screening hundred is even more to be rooted in the hearts of the people, beauty
White nti-freckle becomes popular selection, and skin-lightening cosmetic type is also increasing therewith, have on the market at present cream, lotion, gel,
The whitening products such as facial mask.
Currently, mainly there is a sunlight irradiation in the reason of influencing the colour of skin, endocrine disturbance, pigmentation after wound, sleeping problems,
The factors such as skin water humidity is insufficient, the use of bad cosmetics, and the cutin that gives up is too many.These reasons can often cause melanin excessively raw
Slack-off at the oxidation of, cutin, organism metabolism saccharification, so as to cause pigementation, skin tarnishes and final influences the colour of skin.
Wherein, melanin influences skin color maximum.The forming process of melanin is as follows: when skin is by environmental stimuli
Or when ultraviolet light irradiation, α-melanotropin (α-MSH) in basal layer cell will be with the receiving on melanocyte
Device combines, direct stimulation melanin cell, activated tyrosine, starts to secrete melanin.Free radical is human body as human body waste
Interior important one of endotoxin.Numerous medical researches and clinical test prove: free radical fights for electronics after entering human body everywhere, such as
Fruit destroys protein, can make the increased activity of tyrosinase, generates melanin；Carbohydrate is destroyed, hyaluronic acid can be made to drop
Solution, skin become obscure；Fat is destroyed, lipid peroxidation can be made, local pigment is showed and sexually revise；Destroy cell membrane, interference
The metabolism of cell, cell precipitation form color spot.
Other than age, ultraviolet light can cause melanin increase, excessive sugar is also to cause melanin secretion increase can not
The reason of ignorance.The metabolism of human body mechanism " saccharification " effect in 25 years old or more is gradually slack-off, and the secretion of melanin is enabled to increase, so as to cause
Skin light transmittance is deteriorated.So-called saccharification, be exactly in skin it is excessive sugar and protein react, generate final product AGEs
(Advanced glycation endproducts).AGEs can be combined with the histocyte of body and destroy them, it will lead to skin and declines
Always, relaxation, pigment deposition, allow people to seem many bigger than actual age.In the generating process of melanin, sugar can make tyrosine
Enzyme becomes more active, and then increases the generation of melanin, and skin will gradually become dark yellow, coarse.
Up to now, there are mainly two types of for method for whitening: one is avoid ultraviolet light from reaching the sun-proof method inside skin；
One is avoid black cell from secreting melanin.The oxidant (sodium hypochlorite and hydrogen peroxide) that is conventionally used in whitening and mercurous
Though substance significant effect, since its toxic side effect is larger, so gradually by market.Now it is widely used that quinhydrones, bear
Fruit glycosides, kojic acid and some plant extracts etc..Wherein, quinhydrones has cytotoxicity, is easy to cause permanent hickie；Arbutin has light
Quick property is not suitable for using daytime；Kojic acid is obtained, oxidizable and irritation by refining in Eurotium and the fermentation liquid of Penicillium
It is larger；Plant extracts has certain security risk since its ingredient and the mechanism of action are still not clear.Polypeptide is as novel whitening original
Material acts on the active oxygen (ROS) in melanocyte by antioxidant removal, inhibits because of UV-induced horn cell
The effect of the melanocyte activation factor released, it is possible to reduce the proliferation of melanocyte is accelerated in epidermal keratinocytes
The destruction or reduction of melanin.
Polypeptide is a-amino acid with the compound that peptide bond links together and is formed, and is the intermediate product of protein hydrolysis,
There is homology with body substance, without toxicity or mutagenicity；And molecular weight is small, is easy to Transdermal absorption；Its biochemical physiological mechanism
It is clear；Stability is good in formula, has protective effect to the stability of formula, is to generally acknowledge safer beauty and skin care at present
Raw material.
Glutathione can be got involved in the metabolic process of melanin, effectively reduce ultraviolet light to the thorn of melanocyte
Swash, prevent melanin from being formed in vivo, and then fundamentally inhibit or reduce melanin, prevent melanin deposition, it can be with
Copper ion in tyrosinase combines, and inactivates tyrosinase, and melanin can not be formed by lacking enzyme tyrosine, inhibits spot and sparrow
Spot, so that it is guaranteed that achieving the effect that whitening.
Palmityl tripeptides -5 are a kind of signal peptides of synthesis.It can simulate the sequence of platelet factor4, cause sequence
Column KRFK is tied to sluggish transforming growth factor TGF-β, leads to the release of active TGF-β.TGF-β can make melanocyte
Middle PAX3 expression reduces, and MITF (microphthalmia associated transcription factor) is also lowered therewith, reduces tyrosinase activity and lowers it
Expression, and then reduce the generation of melanin.
Nonapeptide -1 is a kind of bionical peptide, can be with antagonism melanocyte-stimulating hormone α-MSH.On α-MSH and melanocyte
MC1 receptor combine, tyrosinase is activated, further synthesis of melanin.MC1 receptor on nonapeptide -1 and melanocyte has
Extraordinary matching, therefore can be used as the antagonist of melanocyte-stimulating hormone.Nonapeptide -1 just can form source in melanin
Head is blocked, stops the conduction of α-melanotropin information, is avoided in conjunction with recipient on melanocyte, to prevent junket ammonia
Sour enzyme is further activated.There is extraordinary effect to the bad colour of skin and freckle is controlled.
Carnosine is a kind of naturally occurring dipeptides, it to free radical and metal ion cause lipid oxidation have it is significant
Inhibiting effect, the effect that can prevent the aging of skin and skin from brightening.Carnosine can also prevent the trip generated by smoking
From base, and this free radical but will injure skin than sunlight, and free radical is the very strong atom of activity in man or atomic group, energy
It is enough that other materials in human body are aoxidized.In the generating process of melanin, sugar can make tyrosinase become more active, in turn
Increase the generation of melanin, skin will gradually become dark yellow, coarse.
The present invention is had found by many experiments, the polypeptide with different whitening function mechanism is selected, as α-MSH competitiveness is short of money
Anti-agent, free radical scavenger, resists glycosylated substance etc. at tyrosinase inhibitor, forms peptide composition, plays polypeptide and is pressing down
Effect in melanin production processed can achieve the effect of whitening.
Summary of the invention
To overcome above-mentioned the deficiencies in the prior art, the present invention provides a kind of whitening peptide composition and its preparation and use
On the way.The whitening peptide composition can effectively inhibit the activity of tyrosinase, reduce the generation of melanin, reach bright color,
It lightens the stain, improvement skin is dark yellow, brightens the purpose of skin quality.
The technical scheme adopted by the invention is that:
A kind of whitening peptide composition, the whitening peptide composition includes: glutathione, palmityl tripeptides -5, nonapeptide -
1, carnosine.
A kind of whitening peptide composition of the present invention, which is characterized in that be with the whitening peptide composition gross mass
Benchmark, the whitening peptide composition active constituent mass percent range is: glutathione 0.1%-0.5%, palmityl three
- 5 1%-5% of peptide, -1 0.1%-0.5% of nonapeptide, carnosine 0.05%-0.2%.
A kind of whitening peptide composition, which is characterized in that a kind of whitening peptide composition dosage form is selected from:
Capsule, freeze-dried powder, lotion, cream, gel or aqua.
A kind of whitening peptide composition dosage form is cream, which is characterized in that with the whitening peptide composition gross mass
On the basis of, the mass percent range of the cream is: whitening peptide composition 1.25%-8%, moisturizer 5%-15%, cream
Agent 4%-8%, emollient 8%-15%, thickener 0.2%-0.5%, preservative 0.3%-1.0%, arginine 0.1%-
0.2%, pyrenomycetes (SCLEROTIUM ROLFSSII) glue 0.03%-0.08%, allantoin 0.1%-0.2%, tocopheryl acetate
Ester 0.05-2% and water surplus.
The cream, which is characterized in that the moisturizer is selected from butanediol, glycerol, trehalose, 1,5-PD, red
One of moss sugar alcohol is a variety of.
The cream, which is characterized in that the emulsifier is selected from cetearyl glucoside, cetostearyl alcohol, PEG-
One of 100 stearates are a variety of.
The cream, which is characterized in that the emollient is selected from Nexbase 2004, ethylhexyl palmitate, poly- diformazan
One of radical siloxane is a variety of.
The cream, which is characterized in that the thickener is selected from xanthan gum, one of carbomer or a variety of.
The cream, which is characterized in that the preservative is selected from methyl hydroxybenzoate, Nipasol, Phenoxyethanol, to hydroxyl
Acetophenone, decoyl hydroximic acid, pungent glycol, one of Sensiva SC50 or a variety of.
A kind of whitening peptide composition, which is characterized in that a kind of whitening peptide composition is used to prepare face
Film liquid, lotion, smoothing toner, toner, skin cream, skin cream, Essence, lotion, facial cleanser, hand lotion, foundation cream, face cream.
Compared with prior art, the beneficial effects of the present invention are:
Claimed a kind of whitening peptide composition, by 4 kinds of polypeptide moiety collocation with whitening function
At the mutual synergistic effect in inhibition melanogenesis has the function that whitening with melanin generation is reduced.
A kind of whitening peptide composition provided by the invention reduces ultraviolet light to the thorn of melanocyte using glutathione
Swash, fundamentally reduce the generation of melanin, inhibits spot and freckle；- 1 antagonism α-MSH of nonapeptide prevents tyrosinase into one
Step is activated to reduce the generation of melanin, while can pigmentation after prevention of inflammation；Carnosine is in addition to that can remove oxygen freedom
Base, anti-oxidant, anti-aging also have extremely strong anti-glycosylation, can protect skin collagen, for ripe age skin
Yellow effect of dispelling is especially significant；MITF in melanocyte is lowered in release of the palmityl tripeptides -5 due to that can promote active TGF-β
And the expression of tyrosinase, and then reduce the generation of melanin.The present invention is inhibiting melanocyte raw by using four kinds of whitening polypeptides
Mutual synergistic effect in, come the yellow skin whitening that achievees the effect that dispel.Peptide composition safety is higher, allergy rate it is lower and
No cytotoxicity does not influence the function of melanocyte, is a kind of ideal skin-whitening agents.
Specific embodiment
The specific embodiment of form by the following examples makes further specifically the above content invented
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
A kind of cream of the whitening peptide composition of embodiment 1
A kind of cream formula of the whitening peptide composition of table 1
The present embodiment preparation is realized according to following steps:
1, beaker is added water to, A phase is separately added into, 80 DEG C are heated under stirring, opens high speed homogenization 5 minutes and extremely disperses
Uniformly, moderate-speed mixer, it is spare.
2, B phase raw material is separately added into another beaker, is heated to 80 DEG C under stirring, stirring is spare to being completely dissolved.
3, B phase is poured into A phase, after middling speed homogeneous 3 minutes, constant temperature is stirred 5 minutes, stirs lower cooling.
4, when temperature is down to 50 DEG C, the C dissolved in advance is added to, maintains moderate-speed mixer 5 minutes to uniformly completely；
5, when temperature is down to 40 DEG C, then D phase is separately added into, maintains moderate-speed mixer 5 minutes to uniformly completely, detection.
A kind of cream of the whitening peptide composition of embodiment 2
A kind of cream formula of the whitening peptide composition of table 2
The present embodiment preparation is realized according to following steps:
1, beaker is added water to, A phase is separately added into, 83 DEG C are heated under stirring, opens high speed homogenization 5 minutes and extremely disperses
Uniformly, moderate-speed mixer, it is spare.
2, B phase raw material is separately added into another beaker, is heated to 82 DEG C under stirring, stirring is spare to being completely dissolved.
3, B phase is poured into A phase, after middling speed homogeneous 3 minutes, constant temperature is stirred 5 minutes, stirs lower cooling.
4, when temperature is down to 50 DEG C, the C dissolved in advance is added to, maintains moderate-speed mixer 5 minutes to uniformly completely；
5, when temperature is down to 40 DEG C, then D phase is separately added into, maintains moderate-speed mixer 5 minutes to uniformly completely, detection.
A kind of cream of the whitening peptide composition of embodiment 3
A kind of cream formula of the whitening peptide composition of table 3
The present embodiment preparation is realized according to following steps:
1, beaker is added water to, A phase is separately added into, 80 DEG C are heated under stirring, opens high speed homogenization 5 minutes and extremely disperses
Uniformly, moderate-speed mixer, it is spare.
2, B phase raw material is separately added into another beaker, is heated to 84 DEG C under stirring, stirring is spare to being completely dissolved.
3, B phase is poured into A phase, after middling speed homogeneous 3 minutes, constant temperature is stirred 5 minutes, stirs lower cooling.
4, when temperature is down to 50 DEG C, the C dissolved in advance is added to, maintains moderate-speed mixer 5 minutes to uniformly completely；
5, when temperature is down to 40 DEG C, then D phase is separately added into, maintains moderate-speed mixer 5 minutes to uniformly completely, detection.
A kind of cream of the whitening peptide composition of embodiment 4
A kind of cream formula of the whitening peptide composition of table 4
The present embodiment preparation is realized according to following steps:
1, beaker is added water to, A phase is separately added into, 85 DEG C are heated under stirring, opens high speed homogenization 5 minutes and extremely disperses
Uniformly, moderate-speed mixer, it is spare.
2, B phase raw material is separately added into another beaker, is heated to 85 DEG C under stirring, stirring is spare to being completely dissolved.
3, B phase is poured into A phase, after middling speed homogeneous 3 minutes, constant temperature is stirred 5 minutes, stirs lower cooling.
4, when temperature is down to 50 DEG C, the C dissolved in advance is added to, maintains moderate-speed mixer 5 minutes to uniformly completely；
5, when temperature is down to 40 DEG C, then D phase is separately added into, maintains moderate-speed mixer 5 minutes to uniformly completely, detection.
A kind of whitening polypeptide cream of comparative example 1
A kind of whitening polypeptide cream formula of table 5
The present embodiment preparation is realized according to following steps:
1, beaker is added water to, A phase is separately added into, 82 DEG C are heated under stirring, opens high speed homogenization 5 minutes and extremely disperses
Uniformly, moderate-speed mixer, it is spare.
2, B phase raw material is separately added into another beaker, is heated to 83 DEG C under stirring, stirring is spare to being completely dissolved.
3, B phase is poured into A phase, after middling speed homogeneous 3 minutes, constant temperature is stirred 5 minutes, stirs lower cooling.
4, when temperature is down to 50 DEG C, the C dissolved in advance is added to, maintains moderate-speed mixer 5 minutes to uniformly completely；
5, when temperature is down to 40 DEG C, then D phase is separately added into, maintains moderate-speed mixer 5 minutes to uniformly completely, detection.
A kind of whitening polypeptide cream of comparative example 2
A kind of whitening polypeptide cream formula of table 6
The present embodiment preparation is realized according to following steps:
1, beaker is added water to, A phase is separately added into, 80 DEG C are heated under stirring, opens high speed homogenization 5 minutes and extremely disperses
Uniformly, moderate-speed mixer, it is spare.
2, B phase raw material is separately added into another beaker, is heated to 85 DEG C under stirring, stirring is spare to being completely dissolved.
3, B phase is poured into A phase, after middling speed homogeneous 3 minutes, constant temperature is stirred 5 minutes, stirs lower cooling.
4, when temperature is down to 50 DEG C, the C dissolved in advance is added to, maintains moderate-speed mixer 5 minutes to uniformly completely；
5, when temperature is down to 40 DEG C, then D phase is separately added into, maintains moderate-speed mixer 5 minutes to uniformly completely, detection.
A kind of whitening polypeptide cream of comparative example 3
A kind of whitening polypeptide cream formula of table 7
The present embodiment preparation is realized according to following steps:
1, beaker is added water to, A phase is separately added into, 85 DEG C are heated under stirring, opens high speed homogenization 5 minutes and extremely disperses
Uniformly, moderate-speed mixer, it is spare.
2, B phase raw material is separately added into another beaker, is heated to 83 DEG C under stirring, stirring is spare to being completely dissolved.
3, B phase is poured into A phase, after middling speed homogeneous 3 minutes, constant temperature is stirred 5 minutes, stirs lower cooling.
4, when temperature is down to 50 DEG C, the C dissolved in advance is added to, maintains moderate-speed mixer 5 minutes to uniformly completely；
5, when temperature is down to 40 DEG C, then D phase is separately added into, maintains moderate-speed mixer 5 minutes to uniformly completely, detection.
A kind of whitening peptide composition stability test of test example 1
Stability survey is carried out to the whitening polypeptide cream of the embodiment 1-4 containing whitening peptide composition of the present invention
Examination, the results are shown in Table 1.As shown in Table 1, heat-resisting, the cold-resistant and loop test result of whitening polypeptide cream meets middle Chinese
The physical and chemical index of people republic light industry standard QB-T 1857-2013 provides, shows to add whitening peptide composition to whitening
The quality index of polypeptide cream is substantially without influence.
Resistance to Thermal test: (45 ± 1) DEG C constant temperature 15 days whether there is water-oil separating phenomenon after restoring room temperature.
Resistance to cold test: -10 DEG C~-18 DEG C recycle 15 days, whether there is water-oil separating phenomenon after restoring room temperature.
Loop test: 45 DEG C and -10 DEG C observation objects 1 month, restore room temperature after whether there is water-oil separating phenomenon.
A kind of whitening peptide composition cream stability test result of table 8
2 whitening polypeptide cream efficacy test of test example
Experimental subjects: choosing 140 volunteers, and the age between 25-55 years old, is randomly divided into 7 groups, every group of 20 people.
Experimental facilities: German CourageKhazaka electronics corporation MPA9 skin multifunctional tester, including
MexameterMX18 probe, software version 2005.7.14, probe diameter 5mm.
Experimental procedure: 7 groups of experimental subjects use respectively embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1,
Comparative example 2, comparative example 3 respectively use 1 time, application after face cleaning sooner or later daily.Other cosmetics are deactivated during the experiment.Continuous 60
It.
Measurement method: skin colorimetric parameter (L*) is measured in 0d, 15d, 30d, 45d, 60d with tester, comparison uses this
The variation of invention front and back skin L* value, effect of the assessment whitening polypeptide cream to skin-whitening.
Skin colorimetric parameter (L*): referring to and compare with pure white object of reference, the brightness value that subject is observed refers to from pure
Black (L=0) arrives the brightness range of pure white (L=100).
The whitening effect of whitening polypeptide cream of the present invention, as shown in table 2, peptide composition can improve the coloration of skin,
Compared with 0d, 15d after use, skin coloration L* value be increased, and after 60d, L* value, which is significantly greater than, tests preceding level.And with making
Increased with the time, effect is more obvious；Wherein 4 skin coloration L* value rate of rise of embodiment obviously rises；With 1~3 phase of comparative example
Than Examples 1 to 4 skin coloration L* obviously rises.In conclusion the whitening polypeptide cream has significant white-skinned face function.
A kind of variation of the tested period skin coloration L* value of the whitening peptide composition cream of table 9
Above-mentioned detailed description is illustrating for wherein possible embodiments of the invention, and the embodiment is not to limit
The scope of the patents of the invention, all equivalence enforcements or change without departing from carried out by the present invention, is intended to be limited solely by technical solution of the present invention
In the range of.
Claims (10)
1. a kind of whitening peptide composition, which is characterized in that the whitening peptide composition active constituent includes: glutathione,
Palmityl tripeptides -5, nonapeptide -1, carnosine.
2. a kind of whitening peptide composition as described in claim 1, which is characterized in that with the whitening peptide composition gross mass
On the basis of, the whitening peptide composition active constituent mass percent range is: glutathione 0.1%-0.5%, palmityl
- 5 1%-5% of tripeptides, -1 0.1%-0.5% of nonapeptide, carnosine 0.05%-0.2%.
3. a kind of whitening peptide composition as described in claim 1~2, which is characterized in that a kind of whitening polypeptide group
It closes agent type to be selected from: capsule, freeze-dried powder, lotion, cream, gel or aqua.
4. as claimed in claim 3, a kind of whitening peptide composition dosage form is cream, which is characterized in that more with the whitening
On the basis of peptide combinations gross mass, the mass percent range of the cream is: whitening peptide composition 1.25%-8%, moisturizing
Agent 5%-15%, emulsifier 4%-8%, emollient 8%-15%, thickener 0.2%-0.5%, preservative 0.3%-1.0%,
Arginine 0.1%-0.2%, pyrenomycetes (SCLEROTIUM ROLFSSII) glue 0.03%-0.08%, allantoin 0.1%-
0.2%, tocopherol acetate 0.05-2% and water surplus.
5. cream as claimed in claim 4, which is characterized in that the moisturizer is selected from butanediol, glycerol, trehalose, 1,5-
Pentanediol, one of antierythrite or a variety of.
6. cream as claimed in claim 4, which is characterized in that it is hard that the emulsifier is selected from cetearyl glucoside, spermaceti
One of lipidol, PEG-100 stearate are a variety of.
7. cream as claimed in claim 4, which is characterized in that the emollient be selected from Nexbase 2004, palm acid ethyl oneself
One of ester, dimethyl silicone polymer are a variety of.
8. cream as claimed in claim 4, which is characterized in that the thickener be selected from xanthan gum, one of carbomer or
It is a variety of.
9. cream as claimed in claim 4, which is characterized in that the preservative is selected from methyl hydroxybenzoate, Nipasol, benzene oxygen second
Alcohol, parahydroxyacet-ophenone, decoyl hydroximic acid, pungent glycol, one of Sensiva SC50 or a variety of.
10. a kind of whitening peptide composition as described in claim 1, which is characterized in that a kind of whitening peptide composition
Be used to prepare facial mask liquid, lotion, smoothing toner, toner, skin cream, skin cream, Essence, lotion, facial cleanser, hand lotion,
Foundation cream, face cream.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110812271A (en) * | 2019-11-16 | 2020-02-21 | 王洪波 | Polypeptide whitening and spot-fading essence and preparation method thereof |
| CN112618431A (en) * | 2020-12-24 | 2021-04-09 | 广州尚品生物科技有限公司 | Novel whitening composition, preparation method and application |
| CN112826756A (en) * | 2021-01-15 | 2021-05-25 | 广州诺禾生物科技有限公司 | Whitening compound peptide and application thereof |
| CN113318031A (en) * | 2021-06-21 | 2021-08-31 | 杭州友丽医疗科技(集团)有限公司 | Skin beautifying toner composition for removing chloasma, skin beautifying toner and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362088A (en) * | 2015-12-22 | 2016-03-02 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin whitening and spot relieving |
| CN107375005A (en) * | 2017-08-07 | 2017-11-24 | 深圳市维琪医药研发有限公司 | A kind of antioxidation and peptide composition and its application for suppressing B16 cell |
| CN107987124A (en) * | 2017-10-20 | 2018-05-04 | 南京斯拜科生化实业有限公司 | A kind of dipeptide compound and its application |
| CN109157429A (en) * | 2018-09-20 | 2019-01-08 | 深圳市维琪医药研发有限公司 | A kind of active peptides and tyrosinase inhibitor composition for whitening spot-removing |
| CN109432395A (en) * | 2019-01-22 | 2019-03-08 | 宇肽生物(东莞)有限公司 | A kind of whitening spot-removing active peptides |
-
2019
- 2019-04-24 CN CN201910334004.6A patent/CN109893463A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362088A (en) * | 2015-12-22 | 2016-03-02 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin whitening and spot relieving |
| CN107375005A (en) * | 2017-08-07 | 2017-11-24 | 深圳市维琪医药研发有限公司 | A kind of antioxidation and peptide composition and its application for suppressing B16 cell |
| CN107987124A (en) * | 2017-10-20 | 2018-05-04 | 南京斯拜科生化实业有限公司 | A kind of dipeptide compound and its application |
| CN109157429A (en) * | 2018-09-20 | 2019-01-08 | 深圳市维琪医药研发有限公司 | A kind of active peptides and tyrosinase inhibitor composition for whitening spot-removing |
| CN109432395A (en) * | 2019-01-22 | 2019-03-08 | 宇肽生物(东莞)有限公司 | A kind of whitening spot-removing active peptides |
Non-Patent Citations (1)
| Title |
|---|
| 高雅倩等: "棕榈酰三肽-5皮肤美白功效及机制研究", 《日用化学工业》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110812271A (en) * | 2019-11-16 | 2020-02-21 | 王洪波 | Polypeptide whitening and spot-fading essence and preparation method thereof |
| CN112618431A (en) * | 2020-12-24 | 2021-04-09 | 广州尚品生物科技有限公司 | Novel whitening composition, preparation method and application |
| CN112826756A (en) * | 2021-01-15 | 2021-05-25 | 广州诺禾生物科技有限公司 | Whitening compound peptide and application thereof |
| CN113318031A (en) * | 2021-06-21 | 2021-08-31 | 杭州友丽医疗科技(集团)有限公司 | Skin beautifying toner composition for removing chloasma, skin beautifying toner and preparation method thereof |
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