CN113813205A

CN113813205A - Multifunctional eye care composition and application thereof

Info

Publication number: CN113813205A
Application number: CN202111061183.4A
Authority: CN
Inventors: 蒲思凯; 乔变莉; 杨勇
Original assignee: Xianting Guangzhou Technology R & D Co ltd
Current assignee: Xianting Guangzhou Technology R & D Co ltd
Priority date: 2021-09-10
Filing date: 2021-09-10
Publication date: 2021-12-21

Abstract

The invention relates to IPC A61K8/72, in particular to a multifunctional eye care composition and application thereof. The raw materials comprise the following components in parts by weight: 1-10 parts of alkaloid load, 0.01-4 parts of hesperidin and derivatives thereof, 0.1-2 parts of inulin, 1-10 parts of glycerol glucoside and 0.05-1 part of glycogen; the alkaloid load comprises inclusions and inclusions, and the inulin is derived from the extract of the leaves of agave. The nano-encapsulated caffeine with high bioavailability is adopted to act together with water-soluble hesperidin, branched inulin and glycerol glucoside, so that blood microcirculation is promoted, metabolism is accelerated, skin edema is improved, skin touch feeling is optimized, the composition is endowed with fine and plump touch feeling, skin smoothness is improved under low dosage, skin depression and protrusion around eyes are relieved, and fine wrinkles are filled. The eye care composition with the specific composition is applied to the emulsion, and has multiple effects of lightening fine wrinkles of eyes, promoting skin metabolic cycle and the like.

Description

Multifunctional eye care composition and application thereof

Technical Field

The invention relates to IPC A61K8/72, in particular to a multifunctional eye care composition and application thereof.

Background

Periocular skin is the thinnest part of human skin, where skin problems due to aging and bad lifestyle habits are particularly prominent. The subcutaneous part of the eye contains a large amount of blood capillaries, but the sebaceous glands and the sweat glands are less distributed, and the characteristics determine that the self-repairing capability of the eye is weak, but the skin state around the eye is more sensitive. Chinese patent CN201910634276.8 discloses a firming and eye-repairing nursing composition, which adopts carboxymethyl chitosan, European horse chestnut extract, hyaluronic acid, retinol palmitate and other substances to act together to achieve the effect of fading black eyes; the prior art has the functions of removing various dark eye circles and reducing local swelling and pigmentation complications caused by laser treatment of the dark eye circles. CN201811633506.0 discloses an exquisite repair eye cream and a preparation method thereof, which adopts caffeine, glucosyl hesperidin, inositol, bitter orange flower extract, schizosaccharomyces cerevisiae fermentation product lysate and the like to improve the problems of fine lines, edema, dark eye circles and the like of skin. Various functional raw materials are developed aiming at eye skin care at present, but the active factor utilization rate is low due to the particularity of the eye skin, potential safety stimulation hazards exist on the skin, and a certain distance is provided for large-scale application. Under the background, the invention aims to explore the eye care composition which is mild and safe, is easy to be absorbed by skin tissues and has obvious skin care effect, and provides a feasible scheme for the technical progress of skin care products (especially eye care).

Disclosure of Invention

The multifunctional eye care composition provided by the invention solves the problem of low bioavailability of skin around eyes in the prior art, and can improve the bioavailability of the skin.

The invention provides a multifunctional eye care composition, which comprises the following raw materials in parts by weight: 1-10 parts of alkaloid load, 0.01-4 parts of hesperidin and derivatives thereof, 0.1-2 parts of inulin, 1-10 parts of glycerol glucoside and 0.05-1 part of glycogen;

preferably, the alkaloid load comprises inclusions and an encapsulate;

preferably, the inulin is derived from the extract of agave americana leaves.

In some preferred embodiments, the inclusions comprise a combination of one or more of caffeine, ephedrine, vinblastine, berberine, anisodamine, matrine, taxol.

In some preferred embodiments, the coating is a cylindrical-like nanomaterial, and the diameter of the cross-section circumference of the coating is less than 1 nm.

In order to increase the bioavailability of the alkaloid, preferably the content of the alkaloid load is caffeine and the inclusion body is cyclodextrin or a derivative thereof with high glucose residue; the cyclodextrin comprises one or more of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, methyl cyclodextrin, hydroxypropyl cyclodextrin and cyclodextrin laurate. The caffeine accelerates the decomposition of fatty acid triglyceride in human body by inhibiting the action of phosphodiesterase, and has obvious fat reducing effect; meanwhile, the skin care product can promote blood microcirculation, accelerate the discharge of redundant moisture in the skin and relieve local tissue edema. The bioavailability of the caffeine on the skin is limited, and the invention finds that the caffeine is loaded by the nano cyclodextrin in the shape similar to a cylinder, so that the active factors can be prevented from being lost in the transmission process; by utilizing the molecular polar structure characteristics, the encapsulated caffeine molecules are replaced by skin lipid after contacting the skin, and are slowly and continuously released to permeate to the lower part of the skin epidermal layer, the gradual release mechanism obviously improves the absorption rate of the skin epidermal layer to alkaloid, the active function of the caffeine can be exerted for a long time, and the caffeine can effectively eliminate edema, promote the water metabolism of the muscle bottom and improve the skin state of eyes after acting on the periphery of the eyes.

The alkaloid load has the trade name of vigor coffee 50C and the English name of CAFFENERGY 50C, the specification is 5kg, the performance of the alkaloid load is promoting blood microcirculation and reducing fat and resisting oxidation, and the alkaloid load is sourced from Xianting (Guangzhou) trade company Limited.

In some preferred embodiments, the hesperidin and derivatives thereof comprise a combination of one or more of hesperidin, glucosyl hesperidin, hesperidin methyl chalcone.

In some preferred embodiments, the hesperidin methyl chalcone is specifically: the hesperidin is alkalized to form hesperidin chalcone, and the hesperidin chalcone is subjected to methylation reaction to obtain hesperidin methyl chalcone, wherein the structural formula of the hesperidin methyl chalcone is shown in the specification

In order to improve the water solubility of hesperidin, it is further preferable that the hesperidin and the derivatives thereof are glucosyl hesperidin and hesperidin methyl chalcone. Hesperidin is a flavonoid active substance widely existing in citrus peels, and has been proved to have the functions of protecting blood vessels, improving the resistance of capillary vessels and promoting blood circulation. However, hesperidin is extremely insoluble in water, and is difficult to be absorbed and utilized by the body when directly acting on the skin of a human body. According to the invention, through experimental researches, the functional adjustment of the molecular structure of hesperidin is found, so that the solubility of hesperidin in water can be obviously improved, and the hesperidin can be promoted to fully exert the biological activity. Further preferably, glucosyl hesperidin and hesperidin methyl chalcone are added into the eye care composition, so that the absorption and utilization rate of blood to hesperidin is effectively improved, the pressure resistance of capillary vessels is enhanced, blood leakage and inflammation diffusion are inhibited, the eye care composition is applied to eyes, the eye care composition can improve the eye pigmentation caused by blood flow stagnation, and has positive effects of improving the skin color around the eyes and inhibiting skin aging.

In some preferred embodiments, the glucosyl hesperidin is a reaction product of a starch-derived glucose and hesperidin in a weight ratio of starch-derived glucose to hesperidin of 1: (1 to 10), preferably 1: 4; the starch is preferably corn starch.

Preferably, the glucosyl hesperidin is available under the trade name of glycosyl hesperidin, the English name of glucosyl hesperidin is alpha G HESPERIDIN, the specification is 1kg, the glucosyl hesperidin has the performance of promoting skin blood circulation, and the glucosyl hesperidin is sourced from Xianting (Guangzhou) trade company Limited.

Preferably, the methylated hesperidin base is water-soluble hesperidin with the trade name of HESPERIDIN WS, the specification is 25kg, and the methylated hesperidin base is derived from Xianting (Guangzhou) trade company Limited and has the performance of promoting capillary vessel tolerance and regulating vascular permeability.

In order to improve the stability of the eye care composition, it is further preferred that the hesperidin and derivatives thereof comprise a glycosyl hesperidin and/or a water soluble hesperidin.

In some preferred embodiments, the weight ratio of the glycosyl hesperidin to the water-soluble hesperidin is (0-4): (0-3).

In some preferred embodiments, the inulin is branched inulin, and the inulin has a sugar number of 6 to 29.

In order to improve the film forming properties of the eye care composition, the branched inulin is derived from a too deficient agave leaf extract; further preferably, the preparation method of the agave leaf extract comprises the following steps: mixing the Taikui agave core with hot water, filtering, spraying the filtrate on maltose, and drying to obtain the final product; the weight ratio of the filtrate to the maltose is (3-7): 1; preferably 4: 1. The invention discovers that the natural branched polysaccharide is adopted to act on the skin, so that the skin touch can be improved, and a skin beautifying film with a velvet matte texture is formed on the surface of the skin; meanwhile, the agave core extract is mixed with maltose, the obtained mixture has excellent medium compatibility, can improve ductility and silky feeling in oil-based and water-based systems, can generate obvious wrinkle filling effect when acting on the skin, can obviously improve skin concavity and convexity and improve skin smoothness when acting on the periphery of eyes, and has a synergistic effect of lifting and firming the skin when acting together with alkaloid load, hesperidin and derivatives thereof and the like.

Preferably, the extract of the leaves of Pogostemon tequilensis (Agave TEQUILANA) is available under the trade name blue silk skin beautifying agent, with a specification of 1kg, and has the performance of filling wrinkles and improving soft and moist skin feeling, and is sourced from Xiantin (Guangzhou) trade company Limited.

In some preferred embodiments, the molecular structure of the glycerol glucoside comprises a combination of one or more of 2- α GG, 2S-1- α GG, 2S-1- α GG, 2R-1- α GG, 2- β GG, 2S-1- β GG, and 2R-1- β GG.

Preferably, the glycerol glucoside has a molecular structure of 2- α GG.

The glycerol glucoside has strong water replenishing capacity, researches the action mechanism of the glycerol glucoside in plant cells, and transfers the glycerol glucoside to act on a human body to improve the water circulation of the skin to become a skin care product. However, the difficulty of extracting the glycerol glucoside from the plant is high, the cost of the enzymatic catalysis method is extremely high, and the application of the glycerol glucoside in skin care products is limited. In some preferred embodiments, the glycerol glucoside is specifically that glycerol is bonded with glucose by adopting a chemical synthesis method to obtain 2-alpha GG, the 2-alpha GG is dissolved in a solvent, and the glycerol glucoside integrating protection, oxidation resistance, energization, recombination and repair can be obtained by adopting lower production cost. The glycerol glucoside provided by the invention can regulate the osmotic pressure of cells, improve the water distribution and circulation of skin, activate aquaporins, awaken the activity and the regeneration capacity of cells, reduce the release of lactate dehydrogenase in vivo, protect the stratum corneum from being damaged by ultraviolet rays, inhibit the crosslinking of collagen in the skin, and improve the water retention and anti-aging capacity of the skin.

Preferably, the solvent is a mixture of water and glycerol; the 2-alpha GG accounts for 30-40% of the total mass of the glycerol glucoside; more preferably 34%.

Preferably, the glycerol glucoside has the trade name of Jimeisi GG, the specification is 20kg, and the glycerol glucoside has the performance of stabilizing the moisture content of the skin, promoting the activity of cells and protecting the cells under the pressure state; from xiantang (guangzhou) trade company ltd.

In some preferred embodiments, the glycogen is phytoglycogen; preferably, the phytoglycogen is extracted from non-transgenic sweet corn, and high-purity dehydrated phytoglycogen is obtained by a clean mechanical extraction method without using chemical agents or chemical treatment methods. The obtained phytoglycogen has a nano-scale particle size, is high in spreadability on the surface layer of skin, can be quickly and efficiently absorbed by the skin and permeates into the deep layer of the skin, and is low in residual feeling after absorption and not greasy; the highly branched polysaccharide in phytoglycogen supplements energy sources for skin cells, promotes energy conversion and transmission, promotes epidermal healing and repair, can revitalize skin, and reduces skin problems such as hyperpigmentation. The glycogen is characterized in that the glycogen is sold under the trade name of sugar essence, the specification is 1kg, the performance is instant moisture retention, the skin barrier is improved, the skin tolerance is improved, and the skin luster is refreshed; from xiantang (guangzhou) trade company ltd.

In some preferred embodiments, the starting materials of the multi-efficacy eye care composition further comprise a combination of one or more of sodium hyaluronate, lactobacillus/soy fermentation product extract, plant fermentate, lactobacillus/soy milk fermentation product filtrate.

Preferably, the plant fermentation product is a mixture of soybean fermentation broth, Viscum ALBUM (VISCUM ALBUM) leaf extract, and Imperata cylindrical (IMPERATA CYLINDRICA) root extract. The invention discovers that the plant fermentation product with the composition can form a water locking-absorbing-storing action system, efficiently strengthen a skin system, keep the skin elasticity, simultaneously keep the skin moisture, inhibit the moisture loss on the surface of the skin, relieve sensitive skin and strengthen the repair of a skin barrier. Compared with moisturizing components (such as hyaluronic acid) in the prior art, the moisturizing cream can bring soft and moist pleasant moisturizing skin feeling to skin, and can provide light and non-sticky experience feeling to skin while efficiently moisturizing. The plant fermentation product is a moisturizing humectant with the trade name of 10kg, and has the performance of moisturizing, relieving, improving skin barrier and optimizing skin feeling; from xiantang (guangzhou) trade company ltd.

Preferably, the lactobacillus/soybean milk fermentation product filtrate is specifically: inoculating 16 kinds of lactobacillus strain compound of 35 kinds of genus lactobacillus into Japanese black soybean milk, fermenting at 37 deg.C for 5 days, filtering the fermented product, and collecting the filtrate to obtain lactobacillus/soybean milk fermented product filtrate. The lactobacillus/soybean milk fermentation product filtrate has the trade name of oxitenmin, the specification of 20L, the performance of improving the quality and diversity of skin microorganisms, protecting a skin acid mask, soothing and recombining skin and promoting skin hydration; from xiantang (guangzhou) trade company ltd.

In a second aspect, the present invention provides the use of a multifunctional eye-care composition for application in creams, emulsions, serums, moisturizing waters;

the emulsion comprises a lotion and/or cream.

In some preferred embodiments, the eye care composition is applied to an emulsion comprising, in weight percent:

phase A: 1.0-30% of an eye care composition;

phase B: 0.1 to 5.0 percent of emulsifier;

and C phase: 2.0 to 15 percent of emollient,

phase D: 0.1-15% of humectant, 0.01-0.1% of chelating agent and the balance of water;

phase E: 0.1 to 5.0 percent of antioxidant;

and (3) phase F: 0.05 to 5.0 percent of thickening agent;

phase G: 0.1 to 1.0 percent of preservative;

the sum of the weight percentages of the A phase, the B phase, the C phase, the D phase, the E phase, the F phase and the G phase is 100 percent.

In some preferred embodiments, the emulsifier comprises one or more of inulin lauryl carbamate, cetostearyl alcohol, glyceryl stearate, hydrogenated lecithin, polyglyceryl-3 methyl glucose distearate, C12-18 alkyl glucoside, polyacrylate, C18-21 alkane, hydrogenated polydecene, ethylhexyl stearate, C13-14 isoparaffin, isotridecyl isononanoate, mineral oil, dioctyl carbonate, trideceth-6, sorbitan stearate, polyglyceryl-10 stearate, polyglyceryl-6 tristearate, ammonium acryloyldimethyl taurate/VP copolymer, stearic acid in combination.

In some preferred embodiments, the polyacrylate is a combination with a grease and trideceth-6; as examples of polyacrylate-containing salts, there may be mentioned, but not limited to, SNF Flocare ET 75, Flocare ET 76, Flocare ES 502, CRODA Viscostima PL, OptiSense RMA110, Viscostima LV, ASHLAND Rapithiix A-60, Clariant Aristoflex PAL 30, PAL 57 and the like from the company SNF/CRODA/ASHLAND/CLARIANT.

In some preferred embodiments, the emulsifier is inulin lauryl carbamate, and further preferably inulin lauryl carbamate pre-dissolved by vegetable glycerin. Inulin lauryl carbamate is obtained by performing hydrophobic chemical modification on inulin from chicory root through a C12 alkane chain derived from coconut, so that the inulin lauryl carbamate has the characteristics of an emulsion structure of a hydrophilic group and a lipophilic group, and can form an oil-in-water emulsion system with high compatibility. The synergistic mechanism of the main emulsifier and the auxiliary emulsifier is adopted, so that the emulsion is safe, mild and non-irritant, the efficacy of active substances can be amplified, the skin feeling is improved, the temperature of the emulsion used as the emulsifier is wide, the particle size of the emulsion can be reduced, the permeability of a product is improved, and the stability of a formula is further improved due to the unique steric hindrance barrier.

The inulin lauryl carbamate pre-dissolved by the vegetable glycerin is sold as an emulsifier SL1 with the specification of 28kg, and has the performance of improving the stability of a formula, optimizing the skin feel and reducing the cost; from xiantang (guangzhou) trade company ltd.

In some preferred embodiments, the emollient comprises one or more combinations of meadowfoam seed oil, squalane, hydrogenated ethylhexyl olive oil oleate, hydrogenated olive oil unsaponifiables, cyclopentadimethylsiloxane, cyclohexasiloxane, polydimethylsiloxane, methyltrimethylsiloxane, polysiloxane-11, jojoba esters, caprylic/capric triglyceride, hydrogenated polydecene, hydrogenated polyisobutene, isononyl isononanoate, isohexadecane.

In some preferred embodiments, the moisturizer comprises a combination of one or more of polyols, allantoin, sodium hyaluronate, hydrolyzed hyaluronic acid, glycogen, glycerol glucoside, lactobacillus/soy fermentation product extract, ginkgo mistletoe leaf extract, lalang grass rhizome extract, lactobacillus/soy milk fermentation product filtrate, trehalose, bioglycan-1.

In some preferred embodiments, the thickening agent may be selected from natural gums and modifications thereof, such as xanthan gum, guar gum, hydroxypropyl guar gum, sclerotium rolfsii gum, and the like; polyacrylic thickeners may be selected, such as carbomers (polyacrylic acid) and sodium salts, acrylates/C10-30 alkyl acrylate crosspolymer, and the like; cellulose can be selected, such as cellulose, ethyl cellulose, hydroxyethyl cellulose, cellulose gum, methyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, and the like.

In some preferred embodiments, the antioxidant comprises a vitamin derivative and a photoprotectant; as examples of vitamin derivatives, including but not limited to tocopheryl acetate; examples of photo-protecting agents include, but are not limited to, diethylhexyl syringylidenemalonate.

Has the advantages that:

the eye care composition and the emulsion provided by the invention have the following advantages:

the nano-encapsulated caffeine with high bioavailability, water-soluble hesperidin, glycerol glucoside, AGAVE tequilensis (AGAVE TEQUILANA) leaf extract and phytoglycogen are adopted to jointly act, so that on one hand, active substance molecules are protected, and meanwhile, the effects are slowly and continuously exerted, skin edema is relieved, blood microcirculation is promoted, and metabolism is accelerated; on one hand, the anti-tolerance of capillary vessels is improved, the blood infiltration and tissue damage are reduced, the skin dullness is improved, and the healthy skin color of the skin is reproduced; meanwhile, the skin touch feeling is optimized, the composition is endowed with fine and plump touch feeling, the skin smoothness is improved under low dosage, the skin depression and protrusion around eyes are relieved, and fine lines are filled; meanwhile, the eye care composition disclosed by the invention can reduce the damage of UV to skin cells, effectively activate aquaporins, maintain the osmotic balance of the cells, induce the expression of the aquaporins in keratinocytes, improve the water retention of the skin and repair skin barriers. The eye care composition with the specific composition is applied to the emulsion, so that multiple effects of tightening the periphery of eyes, fading fine lines of the eyes, promoting skin metabolic cycle and the like are achieved, fresh and thin skin feeling can be provided, the sense organ is comfortable, the eye care composition is suitable for people with various skin types, and the eye care composition is suitable for being popularized in the field of eye skin care products.

Drawings

FIG. 1. results of ANTERA 3D imaging of volunteers after use of example 2;

FIG. 2 shows the results of the photostability test after 30 days of UV irradiation, from left to right, for the emulsions of examples 3, 4, 5 and 6;

FIG. 3.48 ℃ high temperature stability test results after 30 days of irradiation test, which are the emulsions of examples 3, 4, 5, 6, in order from left to right;

FIG. 4 Low temperature stability test results after 30 days at-18 ℃ for the emulsions of examples 3, 4, 5, 6, in order from left to right.

Detailed Description

Example 1.

The embodiment provides a multifunctional eye care composition, which comprises the following raw materials in parts by weight:

raw materials	Parts by weight (parts)
		Alkaloid load	4
Hesperidin and its derivatives	1
		Inulin powder	0.2
Glycerol glucoside	3
		Glycogen	0.2

The content of the alkaloid load is caffeine, and the inclusion body is cyclodextrin; the alkaloid load has the trade name of vigor coffee 50C and the English name of CAFFENERGY 50C, the specification is 5kg, the performance of the alkaloid load is promoting blood microcirculation and reducing fat and resisting oxidation, and the alkaloid load is sourced from Xianting (Guangzhou) trade company Limited.

The hesperidin and its derivatives are glucosyl hesperidin and hesperidin methyl chalcone.

The hesperidin methyl chalcone is specifically as follows: the hesperidin is alkalized to form hesperidin chalcone, and the hesperidin chalcone is subjected to methylation reaction to obtain hesperidin methyl chalcone, wherein the structural formula of the hesperidin methyl chalcone is shown in the specification

The glucosyl hesperidin is a reaction product of starch source glucose and hesperidin, and the weight ratio of the starch source glucose to the hesperidin is 1: (1 to 10), preferably 1: 4; the starch is preferably corn starch.

The glucosyl hesperidin has a trade name of glycosyl hesperidin, an English name of alpha G HESPERIDIN, a specification of 1kg, and the performance of promoting skin blood circulation, and is sourced from Xianting (Guangzhou) trade company Limited.

The inulin is derived from folium AGAVEs Variegatae (Agave TEQUILANA) extract, and is branched inulin with sugar number of 6-29.

The preparation method of the folium AGAVEs variegatae (Agave TEQUILANA) extract comprises: mixing the Taikui agave core with hot water, filtering, spraying the filtrate on maltose, and drying to obtain the final product; the weight ratio of the filtrate to maltose was 4: 1.

The Taikui tequila (Agave tequila) leaf extract is named as blue silk skin beautifying agent with specification of 1kg, has the performance of filling wrinkles and improving soft and moist skin feeling, and is sourced from Xianting trade company Limited in Guangzhou.

The molecular structure of the glycerol glucoside is 2-alpha GG; specifically, glycerol and glucose are bonded by adopting a chemical synthesis method to obtain 2-alpha GG, and the 2-alpha GG is dissolved in a solvent, wherein the solvent is a mixture of water and glycerol; the 2-alpha GG accounts for 34 percent of the total mass of the glycerol glucoside. The glycerol glucoside has the trade name of Jimei silk GG, the specification is 20kg, the performance is to stabilize the moisture content of the skin, promote the activity of cells and protect the cells under the pressure state; from xiantang (guangzhou) trade company ltd.

The glycogen is phytoglycogen; the phytoglycogen is extracted from non-transgenic sweet corn by a clean mechanical extraction method. The glycogen is characterized in that the glycogen is sold under the trade name of sugar essence, the specification is 1kg, the performance is instant moisture retention, the skin barrier is improved, the skin tolerance is improved, and the skin luster is refreshed; from xiantang (guangzhou) trade company ltd.

The preparation method of the eye care composition comprises the following steps: mixing alkaloid load, hesperidin and its derivatives, inulin, glycerol glucoside, and glycogen uniformly.

Example 2.

This example provides the use of a multifunctional eye care composition, applying the eye care composition provided in example 1 to an emulsion, the emulsion having the raw materials comprising:

The eye care composition is provided for example 1.

The humectant is 0.10% of sodium hyaluronate, 5.00% of 1, 3-butanediol, 3.00% of glycerol and 1.00% of rice bran leavening.

The thickener is xanthan gum, specifically transparent xanthan gum, and is derived from Jungbunzlauer.

The antiseptic is p-hydroxyacetophenone, which is derived from carnation (SYMRISE) with a trade name of carnation ketone.

The emulsifier is 0.65% of first emulsifier and 0.60% of second emulsifier.

The emollient is 2.00% of chinaroot greenbrier (LIMNANTHES ALBA) seed oil and 4.00% of polysiloxane.

The antioxidant is 0.50% of tocopherol acetate, 0.20% of a mixture of diethylhexyl syringylidenemalonate and caprylic/capric triglyceride.

The chelating agent is disodium EDTA.

The sodium hyaluronate comprises high molecular sodium hyaluronate and low molecular sodium hyaluronate, and the mass ratio of the high molecular sodium hyaluronate to the low molecular sodium hyaluronate is 1: 1; the average molecular weight of the high molecular sodium hyaluronate is 130 ten thousand, and the average molecular weight of the low molecular sodium hyaluronate is 7000-8000, and the high molecular sodium hyaluronate is derived from Furuida.

The first emulsifier is a composition of sodium polyacrylate, C18-21 alkane and tridecyl polyether-6; available from xiantang (guangzhou) trade limited under the trade name emulsifier G57.

The second emulsifier is a composition of glycerol and inulin lauryl carbamate; available from xiantang (guangzhou) trade limited under the trade name emulsifier SL 1.

The white meadowfoam (LIMNANTHES ALBA) seed oil is sourced from Xianting (Guangzhou) trade company Limited and is sold as the meadowfoam seed oil.

The Silicone is in particular polydimethylsiloxane, available from Dow-Si (Dow-SIL) under the trade name XIAMETER PMX-200 Silicone Fluid 5 cSt.

The mixture of diethylhexyl syringylidenemalonate and caprylic/capric triglyceride is available from MERCK (MERCK) under the trade name OXYNEX ST LIQUID.

The rice bran fermented product is from Xianting (Guangzhou) trade company Limited and is sold as rice bran fermented product NP.

The preparation process of the emulsion comprises the following steps:

s1, selecting a mixing container A and a mixing container B for cleaning and disinfection;

s2, weighing the D-phase raw material and the alkaloid load in the A-phase, adding the D-phase raw material and the alkaloid load in the A-phase raw material into a mixing container A, stirring and heating to 80 ℃, and uniformly stirring to obtain a first mixture for later use;

s3, adding the raw materials of the phase B and the phase C into a mixing container B, heating to 80 ℃, and uniformly stirring to obtain a mixture II for later use;

s4, slowly adding the mixture II into the mixture I, emulsifying and homogenizing, adding the raw materials of the phase E and the phase F, stirring uniformly, and cooling;

s5, cooling to 45 ℃, adding the residual phase A raw material, and uniformly stirring; and (3) cooling to 40 ℃, adding the G-phase raw material, uniformly stirring, filtering by a 200-mesh sieve, and discharging to obtain a finished product.

Example 3.

This example provides the use of a multifunctional eye care composition, which is applied to an emulsion as described in example 1, in the same manner as example 2; the difference lies in that the raw materials of the emulsion comprise:

wherein the emulsifier is 1.2% of the first emulsifier and 0.8% of the second emulsifier.

The raw materials of the eye care composition comprise:

raw materials	Parts by weight (parts)
		Alkaloid load	10
Hesperidin and its derivatives	4
		Inulin powder	2
Glycerol glucoside	10
		Glycogen	1

Example 4.

This example provides the use of a multifunctional eye care composition, as embodied in example 2; except that the eye care composition was 5% by weight in the emulsion.

Example 5.

This example provides the use of a multifunctional eye care composition, as embodied in example 2; the difference is that the weight portion of the hesperidin and the derivative thereof is 6 portions.

Example 6.

This example provides the use of a multifunctional eye care composition, as embodied in example 2; the different points are that the weight portion of the alkaloid load in the emulsion is 15 portions, and the raw materials of the emulsion comprise:

the experimental variables for each example embodiment are shown in the following table:

	remarks for note
		Example 2	The eye care composition is added in an optimal amount
Example 3	Eye protectorThe physical compositions are added at maximum safe amount
		Example 4	The eye care composition is added in small amount
Example 5	The hesperidin and its derivatives are added in excessive amount
		Example 6	Excessive addition of alkaloid load

Performance test method

1. Eye efficacy testing:

1) ocular edema zone test

2) Ocular foveal area testing

3) Test of Water content of horny layer

4) Transdermal water loss test

The test method comprises the following steps: 13 volunteers were screened for frequent staying up overnight and frequent puffiness of the eyes, accompanied by dark pigmentation of the lower eye. Before the test subjects use the products (eye edema/depressed area test using example 2, stratum corneum water content/percutaneous water loss test using example 3), 14 days after use, 28 days after use, corresponding efficacy tests are carried out, questionnaires are carried out, and the data results and evaluation before and after use of the products are compared and judged by comparing the average value difference of indexes before and after use of 13 volunteers;

preparation work: before each measurement, the face is cleaned, a face cleaning towel is used for lightly wiping the face, and corresponding equipment is adopted to test the skin of the eyes;

the using method comprises the following steps: the test was followed by gently applying the emulsion of example 2 to the eyes at night every day, massaging the eyes from inside to outside until absorption, and testing again before use (D0), at day 14 (14D), and at day 28 (28D)

Testing an instrument:

measuring the eye region of the test subject by using an ANTERA 3D imaging method before using the product and after using the product for 14 days and after using the product for 28 days, specifically measuring the volume of an eye edema region and the volume of an eye depression region; data from one volunteer with significant changes were recorded in table 1, and the results of ant 3D imaging are shown in fig. 1, in comparison to changes in the edema and fovea regions of the eyes.

The stratum corneum moisture content test was performed on the ocular region of the subject before the product was applied, before application (D0), and after 7 days (7D) with the stratum corneum hydration meter DELFIN moisturnetersc, and the results were recorded in tables 2 and 3, with 3 measurements of the same region averaged for each test.

The transdermal water loss content test was performed on the ocular region of the subject before the product was used, before the use (D0), and after 7 days (7D) with the transdermal water loss measuring device DELFIN vapemeter, and the results were recorded in tables 2 and 3, with 3 measurements of the same region being averaged for each test.

2. Stability test

The emulsions prepared in examples 2 to 6 were tested for stability under the following conditions and the results are reported in Table 4.

And (3) stability testing: and (3) placing the sample in constant temperature equipment with the temperature of 48 ℃, 25 ℃, 5 ℃, minus 18 ℃ and UV irradiation for stability test, and regularly taking out the sample to observe whether the appearance of the product has abnormal appearance changes such as obvious discoloration, layering, precipitation and the like.

Performance test data

TABLE 1 Ocular protrusion and indentation region test data

TABLE 2 initial (D0) eye skin moisture test data

TABLE 3 eye skin moisture test data record after 7 days use (7D)

TABLE 4 stability test data

As can be seen from Table 4 and FIGS. 2 to 4, examples 2, 3 and 4 have high stability. Comparative examples 3, 4, 5, 6, fig. 2, example 5 discolored more readily under UV irradiation than the other example samples; as shown in FIG. 3, the high temperature stability of example 5 is poor, and the color of the sample is easily changed compared to other examples; as shown in fig. 4, in example 6, crystallization was more likely to occur at a low temperature. In conclusion, the emulsions obtained in examples 2, 3 and 4 are excellent in stability, and strong in temperature resistance and light stability.

Claims

1. The multifunctional eye care composition is characterized by comprising the following raw materials in parts by weight: 1-10 parts of alkaloid load, 0.01-4 parts of hesperidin and derivatives thereof, 0.1-2 parts of inulin, 1-10 parts of glycerol glucoside and 0.05-1 part of glycogen;

the alkaloid load comprises inclusions and an encapsulation;

the inulin is derived from the extract of leaves of agave americana.

2. The multifunctional eye care composition according to claim 1, wherein the content comprises one or more of caffeine, ephedrine, vinblastine, berberine, anisodamine, matrine, and taxol.

3. The multifunctional eye care composition according to claim 1 or 2, wherein the coating is a cylindrical-like shaped nanomaterial and the diameter of the cross-section circumference of the coating is less than 1 nm.

4. A multi-effect eye care composition according to any one of claims 1 to 3, wherein said hesperidin and derivatives thereof comprise a combination of one or more of hesperidin, glucosyl hesperidin and hesperidin methyl chalcone.

5. A multifunctional eye care composition according to any one of claims 1 to 4 wherein the inulin is branched inulin and has an inulin content of from 6 to 29 sugar moieties.

6. The multifunctional eye care composition according to any one of claims 1 to 5, wherein the molecular structure of the glycerol glucoside comprises a combination of one or more of 2- α GG, 2S-1- α GG, 2S-1- α GG, 2R-1- α GG, 2- β GG, 2S-1- β GG, 2R-1- β GG.

7. The use of a multifunctional eye-care composition according to any one of claims 1 to 6, wherein the eye-care composition is applied to any one of cream, emulsion, essence, moisturizing water; the emulsion comprises a lotion and/or cream.

8. The use of a multifunctional eye care composition according to claim 7, wherein the eye care composition is applied to an emulsion, and the emulsion comprises the following raw materials in percentage by weight:

phase A: 1.0-30% of an eye care composition;

phase B: 0.1 to 5.0 percent of emulsifier;

and C phase: 2.0 to 15 percent of emollient,

phase E: 0.1 to 5.0 percent of antioxidant;

and (3) phase F: 0.05 to 5.0 percent of thickening agent;

phase G: 0.1 to 1.0 percent of preservative;

the weight percentage of the A phase, the B phase, the C phase, the D phase, the E phase, the F phase and the G phase is 100 percent.

9. Use of a multifunctional eye care composition according to claim 8 wherein the emulsifier comprises one or a combination of inulin lauryl carbamate, cetearyl alcohol, glyceryl stearate, hydrogenated lecithin, polyglyceryl-3 methyl glucose distearate, C12-18 alkyl glucoside, polyacrylate, C18-21 alkane, hydrogenated polydecene, ethylhexyl stearate, C13-14 isoparaffin, isotridecyl isononanoate, mineral oil, dioctyl carbonate, trideceth-6, sorbitan stearate, polyglyceryl-10 stearate, polyglyceryl-6 tristearate, ammonium acryloyldimethyltaurate/VP copolymer, stearic acid.

10. Use of a multifunctional eye care composition according to claim 8 or 9 wherein the emollient comprises one or more combinations of meadowfoam seed oil, squalane, ethylhexyl hydrogenated olive oil oleate, hydrogenated olive oil unsaponifiables, cyclopentadimethylsiloxane, cyclohexasiloxane, polydimethylsiloxane, methyltrimethylsiloxane, polysiloxane-11, jojoba esters, diethylhexyl syringylidenemalonate, caprylic/capric triglyceride, hydrogenated polydecene, hydrogenated polyisobutene, isononyl isononanoate, isohexadecane;

the humectant comprises one or more of polyalcohol, allantoin, sodium hyaluronate, hydrolyzed hyaluronic acid, glycogen, glycerol glucoside, lactobacillus/soybean fermentation product extract, folium Visci Ginkgo extract, lalang grass rhizome extract, lactobacillus/soybean milk fermentation product filtrate, trehalose, and biological carbohydrate gum-1.