TWI607764B - External dermal composition for anti-ageing and method for producing the same - Google Patents

Description

Anti-aging skin external composition and preparation method thereof

The present invention relates to an anti-aging skin external composition and a method for producing the same, and more particularly to an anti-aging skin external composition for preventing or improving wrinkles, fine lines, spots or slack, and a base cosmetic containing the same. These manufacturing methods.

It is a common and common desire for human beings to keep young. With the increase of age, the appearance of wrinkles, fine lines, spots, and slacks in the skin of the people in the same area is a long-term experience of human beings, and with age, The skin is also aging, and the appearance of wrinkles, fine lines, spots, and slacks on the skin, that is, the natural destiny, is considered to be inevitable.

However, in recent years, with the progress of research on the structure of human skin and its metabolic mechanism, the cause or mechanism of changes in wrinkles, fine lines, spots, slacks, etc. on the skin of people accompanying age is gradually being clarified. . That is, as known, the skin is thinned from the outside The epidermis (epithelial tissue) is composed of the thick dermis (connective tissue) of the lower layer, and the epidermis is the outermost layer of the body, which protects the living body from the outside while preventing the internal moisture or nutrients from being lost to the outside. In addition, the dermis mainly has fibrous buds. Cells, collagen fibers (collagen), elastin (elastin), proteoglycans, etc., open up into a three-dimensional structure of connective tissue, and give the skin a role of strength, stretch and elasticity, and with age If the amount of sebum or moisture of the skin is known to decrease, the stratum corneum on the surface of the skin loses its moisturizing power, and it is likely to cause fine lines or rough skin due to drying or the like.

In addition, the human epidermis is composed of "the stratum corneum (corner layer)", "granular layer", "with spine layer" and "basal layer" from the outside, and the epidermal cells (keratinocytes) born in the basal layer will The sequence moves to the outside to become the stratum corneum and finally peels off. More specifically, the keratinocyte cell proliferates and differentiates in the basal layer on the innermost side of the epidermis, and is extruded to the upper layer, and finally becomes the stratum corneum (corner layer) located at the outermost side of the epidermis, becoming scale and then falling off. A series of processes of proliferation, migration, differentiation and shedding of this keratinocyte are called transformation. The keratinocytes will regenerate under a certain cycle, and thus maintain skin continuation, but with the increase of age, the skin conversion speed will be slow. The result is wrinkles or sagging, and the skin is rough. The speed of the conversion of the skin varies depending on the part of the human body. In general, the transition of the skin of a healthy person is about 20 days, about 28 days in the 20th, 40 days in the 30s, and 40s in the 40s. It is approximately two times in the age of the 20th, and it is approximately 75 days in the 55th and 50th. Incidentally, the conversion of the skin is not good either fast or slow, and the normal conversion of the skin is considered to be 28th in the 20th. This is due to change If the rate of change is fast, the amount of melanin produced by the melanocytes that absorb ultraviolet rays in the skin increases, and the adhesion of melanin precipitate which is unfavorable in cosmetication is promoted by ultraviolet rays.

Moreover, the findings to date often say that the glycation reaction in the skin of the skin (hereinafter referred to as "glycation reaction") is related to the delay in skin turnover and is related to the aging of the skin. The so-called saccharification reaction is also called the Mena reaction (browning reaction), which means that the reducing sugar such as glucose or fructose is non-enzymatically bonded to the dermis (collagen) or the stratum corneum (keratin), and the resulting formation is called The process up to the substance of the advanced glycation end products (AGEs). It is known that AGEs precipitate to adhere to skin tissue and bind to receptors called RAGE (receptor for AGEs), causing inflammatory changes in skin or other tissues, and collagen during the process of producing AGEs. The disordered cross-linking of intramolecular and intramolecular proteins causes physical and physiological changes (modification) of collagen, causing aging of wrinkles, rough skin, dullness, or reduced firmness. In addition, by the saccharification reaction, collagen which is disorderly cross-linked in the molecule and between the molecules, in addition to the loss of elasticity, is also difficult to be decomposed by the proteolytic enzymes in the living body, and the result may be caused. Delay in skin conversion speed (refer to Non-Patent Document 1).

As mentioned above, the delay in skin conversion rate with age is thought to cause wrinkles, sagging, or rough skin. Therefore, it includes age groups from the age of 30 to 50 before the onset of these skin symptoms. The so-called pre-agging generation of skin, to make It is quite difficult to change the conversion speed back to the normal skin conversion speed of 20 years old. Even if it can be used to recover the delay of the conversion speed caused by the age increase, it can effectively improve wrinkles, sagging or rough skin. From this point of view, there may be at least one process of promoting a process of proliferation, migration, differentiation, and shedding of keratinocytes to increase the rate of conversion, or by hindering a saccharification reaction which is considered to cause a delay in conversion speed. Conversion speed. However, no practical solution has yet been provided.

It is also known that if aging, fibrin cells or hyaluronic acid in the dermis are reduced, and collagen cleavage or modification of elastin occurs, wrinkles are formed, and the elasticity of the skin is lowered, resulting in relaxation. Or rough skin. In addition, it has been pointed out that if melanin which is excreted from melanocytes to epidermal cells cannot be smoothly discharged from epidermal cells, it may cause adhesion (spot) or dull skin to pigmentation of the skin.

Based on these research findings and insights, today, with age, changes in wrinkles, fine lines, spots, and slacks in human skin can be reasonably prevented or improved from a scientific point of view, in other words, to achieve anti-aging. A lot of skin external preparations have been proposed (see, for example, Patent Documents 1 to 7), and human beings are gradually approaching the idea of wanting to keep young. However, the anti-aging skin external preparation currently proposed is only a part of the possibility of pursuing most of the possibilities and is realized. The current situation is that it also contains a mechanism different from the anti-aging effect and is convenient to use. The advantages of sex, even the ease of manufacture, etc., from a more perspective, It is desirable to provide a new skin external preparation for anti-aging.

[Previous Technical Literature]

[Patent Literature]

[Patent Document 1] Japanese Re-publication No. WO2007/011066

[Patent Document 2] Japanese Patent Laid-Open Publication No. 2007-291102

[Patent Document 3] Japanese Patent Laid-Open Publication No. 2008-169196

[Patent Document 4] Japanese Patent Laid-Open Publication No. 2008-255020

[Patent Document 5] Japanese Patent Laid-Open Publication No. 2008-260721

[Patent Document 6] Japanese Patent Laid-Open Publication No. 2009-040690

[Patent Document 7] Japanese Patent Laid-Open Publication No. 2009-249306

[Non-patent literature]

[Non-Patent Document 1] "The Journal of Clinical Investigation", Schnider, S. L., etc., Vol. 67, pp. 1630~1635 (1981)

The present invention has been made in view of the state of the art described above, and provides a novel anti-aging for use in preventing or improving changes in wrinkles, fine lines, spots, slacks, and the like of human skin which occur with age. a skin external composition and a base cosmetic containing the composition, and These manufacturing methods are the subject.

In order to solve the above problems, the present inventors have repeatedly focused on research efforts and found that L-ascorbic acid, derivatives thereof, and the like have excellent anti-aging effects, meaning that a skin having prevention or improvement is found. Wrinkles, fine lines, plaques, slacks, etc., and even skin external compositions having effects of preventing or improving wrinkles, fine lines, spots, sagging, etc., can be obtained by including the above-mentioned L-ascorbic acid and derivatives thereof. The present invention has been completed by easily producing a method in which the salt is mixed with an aqueous medium which is a base.

In other words, the present invention provides an anti-aging skin for external use by using an aqueous medium as a base and containing one or more selected from L-ascorbic acid, a derivative thereof, and the like. The composition and the base cosmetic containing the anti-aging skin composition are used to solve the above problems. Moreover, the present invention provides an anti-aging skin external application comprising a step of mixing one or more selected from L-ascorbic acid, a derivative of L-ascorbic acid and a salt thereof, and an aqueous medium as a base. A method for manufacturing a composition or a basic cosmetic to solve the above problems.

The anti-aging skin external composition of the present invention and the active ingredient of the base cosmetic are basically L-ascorbic acid. However, since L-ascorbic acid is reductive and extremely unstable, it is easy to lose physiological activity. Instead of L-ascorbic acid itself, it is not as good as L-ascorbic acid. Things are more suitable. L-ascorbic acid or a derivative thereof may also be in the form of a salt. L-ascorbic acid is liberated from the salt of L-ascorbic acid in an aqueous medium, and the L-ascorbic acid derivative is liberated from the salt of the L-ascorbic acid derivative in an aqueous medium, and the free L-ascorbic acid derivative is applied to In human skin, L-ascorbic acid is further released by the action of enzymes present in human life. Therefore, in addition to L-ascorbic acid, the anti-aging skin external composition and the base cosmetic of the present invention may be selected from a salt of L-ascorbic acid, a salt of L-ascorbic acid, and a salt of an L-ascorbic acid derivative. One or two or more kinds are active ingredients having an anti-aging effect of preventing or improving skin wrinkles, fine lines, spots, and slacks due to age.

In terms of derivatives of L-ascorbic acid, it is preferred to use a glycosyl derivative, a thiolated derivative, or a phosphorylated derivative of L-ascorbic acid, wherein 2-O- which is a glycosyl derivative of L-ascorbic acid The α-D-glucosyl-L-ascorbic acid or the sodium salt thereof is more suitable because it is highly stable in the skin external composition of the present invention and even in the base cosmetic, and exhibits a remarkable anti-aging effect.

2-O-α-D-glucosyl-L-ascorbic acid and its sodium salt are preferably those in which the respective crystalline forms are used. For the crystallization of 2-O-α-D-glucosyl-L-ascorbic acid, which is disclosed in Japanese Patent Laid-Open No. Hei 3-135992, No. 2012-67013, and the like. A powder containing 2-O-α-D-glucosyl-L-ascorbic acid anhydrous crystals.

Further, in the crystallization of the sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid, the diffraction angle (2θ) is 6.8° in the powder X-ray diffraction. The hydrated crystals of the diffraction peaks at 8.2°, 14.3°, 17.8°, and 18.4°, or diffraction at diffraction angles (2θ) of 8.0°, 9.0°, 16.4°, 17.9°, and 20.8° Anhydrous crystal of the peak. The hydrated crystals and anhydrous crystals of the sodium salt of the 2-O-α-D-glucosyl-L-ascorbic acid are novel crystals created by the present inventors, and are highly purified due to crystallization. Therefore, the physical properties and the effectiveness are improved, and the safety is confirmed to be easy, and the advantage of being used as an active ingredient is easily modulated. In the present invention, it is particularly suitable as an active ingredient.

In addition, 2-O-α-D-glucosyl-L-ascorbic acid, which is a glycosyl derivative of L-ascorbic acid, exhibits strong acidity in an aqueous medium, and is blended for use in humans. When the external skin preparation or cosmetic of the skin is used, it is usually necessary to neutralize the pH with a suitable alkali to give a pH of about 5 to 9. However, the aqueous crystals and anhydrous crystals of the sodium salt of the above 2-O-α-D-glucosyl-L-ascorbic acid are alkaline due to the use in the aqueous medium, when 2-O-α-D- is used in combination. When glucosyl-L-ascorbic acid and its sodium salt are crystallized, it is possible to neutralize 2-O-α-D-glucosyl-L- without using a base by appropriately adjusting the blending ratio of the two. Ascorbic acid is an excellent advantage in that it can produce a skin external composition or a base cosmetic in a desired range of pH. When both are used together, a composition obtained by previously mixing aqueous crystals and/or anhydrous crystals of 2-O-α-D-glucosyl-L-ascorbic acid with a sodium salt thereof at an appropriate ratio is used. The pH after mixing with the aqueous medium falls within a predetermined range. Further, in the case of a skin external composition or a base cosmetic which may be alkaline, for example, as a facial cleanser, it may of course not be used in combination with 2-O-α-D-glucosyl-L-ascorbic acid. As the active ingredient, only hydrous crystals and/or anhydrous crystals of the sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid can be used.

The skin external composition of the present invention can be used alone as a skin external composition for anti-aging, but it is preferred to use a suitable cosmetic ingredient for general use as a base cosmetic. For example, in the anti-aging skin external composition of the present invention, ethanol and a moisturizing agent may be added as a lotion, and in the lotion, one or more astringents and keratolytic agents may be separately blended. Softener, or surfactant. In such a lotion, one or two or more kinds of fragrances, coloring matters, preservatives, bactericides, ultraviolet absorbers, metal blocking agents or buffers may be added arbitrarily.

Further, in the anti-aging skin external composition of the present invention, an alkali salt (soap) of a higher fatty acid may be added as a face-washing agent, and one or two or more kinds of flavors, pigments, and anti-drugs may be added to the facial cleanser. An oxidizing agent, or a metal blocking agent. In such a facial cleanser, it is of course possible to further blend glycerin, ethanol, granulated sugar, polyol or bactericide.

In the anti-aging skin external composition of the present invention, a moisturizing agent and a softening agent may be added as a cosmetic liquid, and one or two or more kinds of fragrances, ultraviolet absorbers, whitening agents, and anti-inflammatory substances may be separately added to the cosmetic liquid. Agent, preservative, or bactericide. Further, in the anti-aging skin external composition of the present invention, an appropriate oily component and a surfactant may be added as an emulsion, and one or more kinds of humectants and softeners may be appropriately blended in the emulsion. , blood promoting agent, or high molecular substance. Furthermore, the anti-aging skin external composition of the present invention may be suitably added thereto. The oily component and the surfactant are used as a cream, and in the cream, cetyl wax, cetyl alcohol, lanolin, mobile paraffin, petrolatum, glycerin, or squalane may be appropriately blended.

According to the anti-aging skin external composition of the present invention or the base cosmetic containing the composition, it is possible to effectively prevent or improve the change of skin such as wrinkles, fine lines, spots, and relaxation with age. In particular, in the case of using an active ingredient as 2-O-α-D-glucosyl-L-ascorbic acid or a sodium salt thereof as a glycosyl derivative of L-ascorbic acid, the following advantages are obtained: active ingredient It can be kept in a stable skin external composition or basic cosmetic, and can exert a remarkable anti-aging effect when applied to the skin. Further, in the case of using 2-O-α-D-glucosyl-L-ascorbic acid and/or its sodium salt, when it is used in a crystalline form, it has the advantage that the impurities contained in the raw material can be excluded as much as possible. The extremely high-purity 2-O-α-D-glucosyl-L-ascorbic acid and/or its sodium salt can be used as an active ingredient of a skin external composition or a basic cosmetic, so that the safety is extremely high and can be safely applied. On the skin. Further, in the case of producing the anti-aging skin external composition of the present invention or the base cosmetic containing the composition, when 2-O-α-D-glucosyl-L-ascorbic acid and its sodium salt are used in combination, The following advantages: when mixed with an aqueous medium, it exhibits relatively strong acidity relative to 2-O-α-D-glucosyl-L-ascorbic acid, and its sodium salt can be alkaline due to its Properly considering the ratio of both, it is possible to manufacture without having to neutralize 2-O-α-D-glucosyl-L-ascorbic acid with a base. A skin external preparation or a base cosmetic having a desired range of pH.

In Figure 3,

FT-IR Spectra of Anhydrous Crystalline of A.‧‧ Ascorbic Acid 2-Glucosidin-Sodium Salt

FT-IR spectrum of B‧‧‧ powder containing anhydrous ascorbic acid 2-glucoside anhydrous crystals (control)

In Figure 4,

Powder X-ray diffraction pattern of aqueous crystals of A‧‧‧ ascorbic acid 2-glucoside-sodium salt

B.‧‧Aqueous X-ray diffraction pattern of anhydrous crystalline ascorbic acid 2-glucoside-sodium salt

C‧‧‧Aqueous X-ray diffraction of ascorbic acid 2-glucoside containing water-containing crystalline powder (Control 1)

Powder X-ray diffraction pattern of D‧‧‧ powder containing ascorbic acid 2-glucoside anhydrous crystals (Control 2)

Fig. 1 is a photomicrograph of ascorbic acid 2-glucoside-sodium salt crystals (aqueous crystals).

Fig. 2 is a photomicrograph of ascorbic acid 2-glucoside-sodium salt crystals (anhydrous crystals).

Fig. 3 is a graph comparing infrared absorption spectra of anhydrous crystallization of ascorbic acid 2-glucoside-sodium salt and anhydrous crystallization of ascorbic acid 2-glucoside.

[Fig. 4] Comparison of aqueous crystals of ascorbic acid 2-glucoside-sodium salt, anhydrous crystal of ascorbic acid 2-glucoside-sodium salt, ascorbic acid 2-glucoside aqueous crystal, and ascorbic acid 2-glucoside anhydrous crystal powder X-ray winding Map of the map.

Fig. 5 is a single crystal X-ray diffraction pattern of aqueous crystals of ascorbic acid 2-glucoside-sodium salt.

[Formation for implementing the invention]

The present invention relates to an anti-aging skin external composition comprising one or more selected from the group consisting of L-ascorbic acid, a derivative thereof, and the like, and an aqueous medium as a base. The base cosmetic for the anti-aging skin external composition, and the method for producing the same. Hereinafter, the composition for external use of the skin for anti-aging of the present invention is firstly The materials are explained, and then the basic cosmetics of the present invention and the production methods thereof will be described.

A. Anti-aging skin external composition

The skin external composition for anti-aging of the present invention (hereinafter referred to as "the external composition for skin") contains one or more selected from L-ascorbic acid, a derivative thereof, and the like as an active ingredient. By. L-ascorbic acid, in addition to being an important physiological function in the living body as a vitamin C, can also be used as an antioxidant and an anti-inflammatory agent, and because of its whitening effect and collagen production, it has been in the field of cosmetics since ancient times. That is, a compound that is generally used as a useful component. L-ascorbic acid is incorporated in the external composition for skin, and is effective as an active ingredient in the external composition for skin of the present invention because it can effectively prevent or improve wrinkles, fine lines, spots, and slack.

However, L-ascorbic acid is extremely unstable due to its reducibility, and has a drawback that it is easily decomposed by oxidative decomposition and loses physiological activity. Therefore, in addition to careful attention to preservation and sputum removal, L-ascorbic acid must be blended into the skin external composition of cosmetics or the like, and it is necessary to predict the amount of oxidative decomposition until use, and blending is far more necessary than originally. A larger amount. Therefore, the active ingredient in the external composition for skin of the present invention is more stable than L-ascorbic acid itself, and L-ascorbic acid is released in the living body to exert the original function of L-ascorbic acid L-ascorbic acid. Derivatives or salts thereof are more suitable.

In terms of the active ingredient of the external composition for skin of the present invention, a preferred derivative of L-ascorbic acid is a derivative of L-ascorbic acid. The ascorbic acid is more stable, and L-ascorbic acid is released in the living body, and the original function of L-ascorbic acid is not particularly limited. Examples of the derivative of L-ascorbic acid which is an active ingredient of the external composition for skin of the present invention include a glycosyl derivative of L-ascorbic acid, a thiolated derivative of L-ascorbic acid, and a phosphorylated derivative.

In the case of a glycosyl derivative of L-ascorbic acid, a derivative having a glycosyl group bonded to the 2-position of L-ascorbic acid is suitably used because of its high stability. In the case of the L-ascorbic acid disclosed in Japanese Laid-Open Patent Publication No. Hei No. Hei No. Hei No. Hei No. Hei. The saccharide group is an α-bonded 2-O-α-glycosyl-L-ascorbic acid (ascorbic acid 2-glycoside), or, for example, L-ascorbic acid disclosed in Japanese Laid-Open Patent Publication No. Hei 6-263790 The position has a galactosyl group of β-bonded 2-O-β-D-galactosyl-L-ascorbic acid (ascorbic acid 2-galactoside).

In addition, the thiolated derivative (fatty acid ester derivative) of L-ascorbic acid, for example, JP-A-59-10505, JP-A-63-104971, and JP-A-6-247956 Ascorbic acid-palmitate, ascorbic acid-di-peripate, ascorbic acid-tetrahexyl decanoate, ascorbic acid-cholesteryl ester, etc., and phosphorylation of L-ascorbic acid, as disclosed in Japanese Laid-Open Patent Publication No. 2004-331524 Ascorbic acid 2-phosphate disclosed in, for example, JP-A-61-152613, JP-A-H05-339123, JP-A-2002-3330, JP-A-2006-63060, and the like. Ester or its various metal salts and the like.

Among the various derivatives of the above-mentioned L-ascorbic acid, the glycosyl derivative of L-ascorbic acid is most suitable for high stability, and further, there are glucosyl groups at the 2-position of L-ascorbic acid with α-bonded 2 -O-α-D-glucosyl-L-ascorbic acid (hereinafter, simply referred to as "ascorbic acid 2-glucoside" in the present specification) is optimal. Ascorbic acid 2-glucoside is a derivative of L-ascorbic acid developed to eliminate the above-mentioned disadvantages of L-ascorbic acid, and does not directly exhibit reducibility, stability, and can be decomposed into L by living enzymes in living organisms. - Ascorbic acid and D-glucose exert the original physiological activity of L-ascorbic acid, and thus have a striking property. Ascorbic acid 2-glucoside is disclosed in, for example, Japanese Laid-Open Patent Publication No. Hei 3-135992, and Japanese Patent Application Laid-Open No. Hei No. 3-139288. In a solution containing L-ascorbic acid and starch, cyclodextrin is used. The glucosyltransferase acts as a glycosyltransferase, and is then produced on an industrial scale by the method of causing glucoamylase to act on the resulting ascorbic acid 2-glycoside.

Ascorbic acid 2-glucoside is suitable for those which are partially or wholly crystalline. That is to say, the proportion of the crystals of the whole ascorbic acid 2-glucoside is high, and the physical properties are also stable and preferable, but it is not necessary to use the whole ascorbic acid 2-glucoside in a completely crystalline form, and even if there is a part A crystal-containing powder in which an amorphous substance is mixed may also be used. The presence of the anhydrous crystallization of the ascorbic acid 2-glucoside is known, and it is suitable for the crystallization of the ascorbic acid 2-glucoside of the present invention, and the above-mentioned Japanese Patent Laid-Open No. Hei 3-135992, International Publication No. A powder containing 2-O-α-D-glucosyl-L-ascorbic acid anhydrous crystals disclosed in WO2012/121297, and commercially available products containing ascorbic acid as a cosmetic and cosmeceutical material. - A powder of glucoside anhydrous crystals (trade name "AA2G", sold by Linyuan Co., Ltd.).

Further, in the external composition for skin of the present invention, a derivative of L-ascorbic acid or L-ascorbic acid which is an active ingredient is used, and when mixed with an aqueous medium, the derivative of L-ascorbic acid or L-ascorbic acid is dissociated, and For the form of salt.

The salt which is particularly useful as an active ingredient in the external composition for skin of the present invention is a sodium salt of ascorbic acid 2-glucoside. The sodium salt of ascorbic acid 2-glucoside can be obtained, for example, by neutralizing an aqueous solution of ascorbic acid 2-glucoside using a base such as sodium hydroxide. The sodium salt of ascorbic acid 2-glucoside, if dissolved in an aqueous medium, varies depending on the pH, but at least partially dissociates into ascorbic acid 2-glucoside and sodium, and thus is particularly suitable for use in the present invention as with ascorbic acid 2-glucoside. .

Further, the sodium salt of ascorbic acid 2-glucoside is more suitable for the user in the form of crystals as in the case of ascorbic acid 2-glucoside. The crystallization of the sodium salt of ascorbic acid 2-glucoside is a novel crystal created by the present inventors. That is, the crystal of the metal salt of ascorbic acid 2-glucoside, although a crystalline powder of an aluminum salt or a zinc salt has been proposed in Japanese Patent Publication No. 6-220081, the report on the crystallization of the sodium salt is reported. does not exist. In addition, in the above publication, the ascorbic acid 2-glucoside and the aluminum compound are dissolved in cold water, stirred, and centrifuged, and the supernatant is removed. To freeze-dry or add NaOH to the zinc compound, stir and centrifuge, and then add the obtained precipitate to an aqueous solution of ascorbic acid 2-glucoside. After filtering, the filtrate is freeze-dried to obtain ascorbic acid 2- A crystalline powder of an aluminum salt or a zinc salt of glucoside. However, the present inventors have repeatedly operated the same method as the above-mentioned publication in order to obtain the crystal of the sodium salt of ascorbic acid 2-glucoside, but the method of obtaining any of the crystalline powder of the aluminum salt or the zinc salt However, it is impossible to obtain a crystalline powder of the sodium salt of ascorbic acid 2-glucoside.

The present inventors further studied and repeated the trial results, and accidentally added an excess of sodium hydroxide as an aqueous solution to the ascorbic acid 2-glucoside to form an alkaline solution, and then added the alkaline solution. The organic solvent was allowed to stand, and the crystal of the ascorbic acid 2-glucoside-sodium salt was successfully obtained.

As shown in the experiment described later, the sodium salt crystal of ascorbic acid 2-glucoside found by the present inventors can also obtain any form of aqueous crystals and anhydrous crystals, and aqueous crystals of ascorbic acid 2-glucoside-sodium salt in powder X-ray. In the diffraction, characteristic diffraction peaks are exhibited at diffraction angles (2θ) of 6.8°, 8.2°, 14.3°, 17.8°, and 18.4°, while anhydrous crystals of ascorbic acid 2-glucoside-sodium salt are in powder. In the X-ray diffraction, characteristic diffraction peaks are exhibited at diffraction angles (2θ) of 8.0°, 9.0°, 16.4°, 17.9°, and 20.8°. Further, the inventors of the present invention have succeeded in obtaining a single crystal having a resolution of the X-ray crystal structure, and analyzing the structure by X-ray crystal structure, as described in the experiment below, on the aqueous crystal of the ascorbic acid 2-glucoside-sodium salt. It is known that the hydrous crystal belongs to the orthorhombic system and the display space group is Pbca (#61), the grid number is a = 6.9733 Å, b = 14.48839 Å, c = 19.3221.

Incidentally, the sodium content in the anhydrous crystal of the sodium salt is about 8.7% by mass based on the inductively coupled plasma luminescence spectroscopic analysis described later. Further, the above anhydrous crystal is formed by ascorbic acid 2-glucoside, sodium and sodium hydroxide, and the content ratio thereof is assumed to be 1 atom and sodium hydroxide (1/2) for the ascorbic acid 2-glucoside 1 molecule. The theoretical value of the molecular content of sodium is 8.8% by mass, which is in good agreement with the measured value. At this time, the molar ratio of ascorbic acid 2-glucoside to sodium is about 1:1.5, that is, two of ascorbic acid 2-glucoside contain three sodium. Further, as shown by the measurement result of the water content described later, the water content in the aqueous crystal of the sodium salt of ascorbic acid 2-glucoside is about 15% by mass, and it is assumed that the aqueous crystal contains ascorbic acid 2 in the same molar ratio as in the anhydrous crystal. - Glucosamine, sodium and sodium hydroxide, the molar ratio of ascorbic acid 2-glucoside to water molecule is about 1:4, and the aqueous crystal is one molecule of crystal water containing ascorbic acid 2-glucoside 1 molecule.

In general, an organic compound is considered to exhibit a crystal polymorphism, and even if it is the same compound, a plurality of different crystal structures can be obtained, and various physical properties such as solubility may be different depending on the difference in crystal structure. . Therefore, when an organic compound is used as an active ingredient in a skin external composition or a basic cosmetic, for example, in order to stably maintain and ensure physical properties suitable for the application, when crystals are present in the organic compound, crystals are obtained and the crystal structure is further explained. It is extremely useful. The skin external composition or the basic cosmetic of the present invention, although using ascorbic acid 2-Port The sodium salt of glycosides is a preferred active ingredient, but now, according to the present inventors, crystals of the sodium salt of ascorbic acid 2-glucoside have been obtained, and the crystals are clearly present in the presence of anhydrous crystals and aqueous crystals, and are carried out. There is an analysis of the powder X-ray diffraction pattern or crystal structure imparting such crystal characteristics, and the use of the above-mentioned anhydrous crystalline or hydrous crystalline form of ascorbic acid 2-glucoside sodium salt has the advantage of easily modulating high-purity materials. In addition, it can be easily implemented in the confirmation of its availability, effectiveness, and safety, and it is possible to constantly fix the excellent physical properties that are expected to be stable.

The method for producing the ascorbic acid 2-glucoside-sodium salt crystal used in the present invention is not particularly limited as long as it can obtain a desired crystal. For example, after dissolving ascorbic acid 2-glucoside in an aqueous sodium hydroxide solution, an organic solvent is added. The crystals are precipitated by standing, and then the crystals are recovered by a solid-liquid separation method such as centrifugation to obtain a hydrous crystal of the ascorbic acid 2-glucoside-sodium salt. In this case, the ascorbic acid 2-glucoside which is used as a raw material is preferably a high purity, and is usually ascorbic acid 2-glucose having a purity of 90% by mass or more, preferably 95% by mass or more, and more preferably 99% by mass or more. The anhydrous crystalline glucoside is preferred as a raw material.

By washing the obtained aqueous crystals with aqueous ethanol, it becomes a highly pure aqueous crystal. The obtained hydrous crystals can be pulverized and dried as needed to form a hydrous crystal powder containing ascorbic acid 2-glucoside-sodium salt. Further, the aqueous crystal obtained by the above method was converted into an anhydrous crystal of the ascorbic acid 2-glucoside-sodium salt by vacuum drying while heating. Further, the obtained anhydrous crystals can be again converted into aqueous crystals by absorbing moisture under conditions of a relative humidity of 75% or more. Further, the crystals are precipitated by adding an organic solvent, and the mass set thus obtained is spray-dried to obtain a hydrated crystal powder or an anhydrous crystal powder containing ascorbic acid 2-glucoside-sodium salt.

One of the characteristics of the anhydrous crystalline or hydrous crystal of the ascorbic acid 2-glucoside-sodium salt is that when the anhydrous crystal or the aqueous crystal is dissolved in water, the obtained aqueous solution exhibits basicity. When the anhydrous crystals of ascorbic acid 2-glucoside are dissolved in water, the obtained aqueous solution will show strong acidity as the best control. Therefore, the novel ascorbic acid 2-glucoside-sodium salt crystals created by the present inventors are crystallized by the conventional ascorbic acid 2-glucoside anhydrous crystals, and the aqueous solution thereof exhibits strong acidity, and is also suitable for use or use form. It is used in its own restricted use. For example, when it is used for a skin external composition which is required to be weakly alkaline, for example, soap, shampoo, facial cleansing foam, shower gel, etc., a conventional powder containing anhydrous crystalline ascorbic acid 2-glucoside is used. When necessary, an acidic solution of ascorbic acid 2-glucoside dissolved in an aqueous medium may be previously neutralized with a base, or a buffer for pH adjustment may be added, but crystallization of ascorbic acid 2-glucoside-sodium salt may be obtained. The aqueous solution usually shows alkalinity, and when it is blended into the external composition for skin, there is no need to use an alkali to neutralize the ascorbic acid 2-glucoside. In most cases, it is not necessary to use a buffer together.

Further, when the anhydrous crystalline or aqueous crystal of the ascorbic acid 2-glucoside-sodium salt is combined with the anhydrous crystalline form of ascorbic acid 2-glucoside, it can be obtained by adjusting the blending ratio of the two to dissolve in an aqueous medium. The pH falls within a predetermined range, for example, a range of weakly alkaline to weakly acidic An aqueous solution of ascorbic acid 2-glucoside in the like. Therefore, when the anhydrous crystalline or aqueous crystal of the ascorbic acid 2-glucoside-sodium salt is used in combination with the anhydrous crystallization of ascorbic acid 2-glucoside, it is not necessary to use an anhydrous crystal of the ascorbic acid 2-glucoside-sodium salt or a base other than the aqueous crystal. And the ascorbic acid 2-glucoside, which comprises the skin external composition or the base cosmetic of the present invention, is advantageous in that various compositions which are preferably in a range of weakly alkaline to weakly acidic can be produced. In addition, when both are used together, in the manufacture of various compositions, although anhydrous crystals of ascorbic acid 2-glucoside and anhydrous crystals or aqueous crystals of ascorbic acid 2-glucoside-sodium salt can be used, only the respective blending ratios can be calculated. The amount can be used, and the anhydrous crystallization of ascorbic acid 2-glucoside and the anhydrous crystalline or aqueous crystallization of ascorbic acid 2-glucoside-sodium salt can be preliminarily blended according to the desired pH of the target composition. The composition is preferably a composition in which a mass ratio of 60:40 to 45:55 in terms of an anhydrous substance is blended in advance to form a composition. Further, the anhydrous crystalline or hydrous crystal of the ascorbic acid 2-glucoside-sodium salt or the anhydrous crystalline form of ascorbic acid 2-glucoside in the skin external composition or the basic cosmetic of the present invention, in the L-ascorbic acid anhydrate The total amount of the conversion is usually 0.001% by mass or more, preferably 0.01 to 50% by mass, more preferably 0.1 to 20% by mass, even more preferably 1 to 10% by mass of the skin external composition or the base cosmetic per unit mass. %. If it is less than the lower limit of the above-mentioned blending amount or higher than the upper limit of the blending amount, it is not preferable because the desired effect is remarkably lowered.

As described above, the effective composition of the external composition for skin of the present invention In some aspects, it is preferred to use ascorbic acid 2-glucoside and/or its sodium salt. The sodium salt of ascorbic acid 2-glucoside is at least partially dissociated into ascorbic acid 2-glucoside and sodium in an aqueous medium, and produces ascorbic acid 2-glucoside. Further, ascorbic acid 2-glucoside can be hydrolyzed into L-ascorbic acid and D-glucose by the action of an enzyme such as α-glucosidase in the living body, and functions as L-ascorbic acid. Therefore, by incorporating the α-glucosidase inhibitor as needed in the external composition for skin of the present invention, the production of L-ascorbic acid when applied to the skin is delayed, and the anti-aging effect can be made persistent or late. Line. Conversely, by incorporating the α-glucosidase activating agent as needed in the external composition for skin of the present invention, the production of L-ascorbic acid suitable for skin can be made early, and the effect is maintained. .

In the aspect of the α-glucosidase inhibitor, any of antagonistic and non-antagonistic inhibitors can be used, and specific α-glucosidase inhibitors include maltotriose and maltotetraose. Starch hydrolysate of maltopentaose, maltoheptaose, pannoose, etc.; maltitol, maltotriitol, maltotetraol, maltopentaitol, maltohexaitol, maltoheptaose Alcohol, butanol, 1-thio-D-glucitol, etc.; arabinose, staghorn, 2-deoxy-D-galactose, xylose, ribose, tagatose, ribulose, Monosaccharides such as threose, xylulose, α-methyl-D-xyloside; oligosaccharides derived from fucoidan, oligosaccharides or polysaccharides derived from soybean polysaccharides; adenine nucleotides, bird droppings Nucleotides, cytosine nucleotides, uracil nucleotides, inosine nucleotides, etc.; guanosine nucleosides, deoxyguanosine nucleosides, adenosine nucleosides, deoxyadenosine nucleosides Cytosine, uridine , nucleosides, deoxynucleosic nucleosides and other nucleosides; Panax ginseng, Aloe vera, Hypericum erectum, Malva sylvestris, salacia reticulata ), Connarus cochinchinensis, sapium discolor, Xanthophyllum annamense, Paris, Dimocarpus longan, Erythroxylon cambodianum, Luzon Diospyros malabarica, bean drum, Careya arborea, mulberry, Semecarpus cochinchinensis, Calophyllum calaba, Duabanga sonneratioides, ox (Cratoxylon formosum), Archidendron Turgidum, Nauclea officinalis, Eupatorium odoratum, Hibiscus mesnyi, Myrcia sphaerocarpe, Spatholobus ( Milletia diptera), Milletia conraui, Ascophyllum nodosum, Brucea javanica, Mangifera indicia, Sesbania grandiflora, licorice (Glycyrrhiza uralensis), Rumex bucephalophorus, Murtex Communis, Taraxacum officinale, Viscum album, Ganoderma lucidum, Pinus densiflora, Penare (Penarus schulzei), Origanum Majorana, Grifola frondosa, Sangzhi, Lobelia chinensis, Angelica acutiloba, Syzygium aromaticum, Commelina communis, salacia reticulata, Eucommia ulmoides, Angylocalyx boutiqueanus, Aurora Arachniodes standishii), Laurus nobilis, kappa leaf, chestnut mink, peanut mink, purple rice and other plant extracts.

Further, examples of the α-glucosidase activator include extracts of plants such as rabbit, wild chrysanthemum, sage, soybean, and genus, or microorganisms such as yeast, Bifidobacterium, and lactic acid bacteria. Extracts.

Further, in the skin external composition of the present invention, if a plant extract or a compound having a skin transformation improving effect described later is blended as needed, the active ingredient L-ascorbic acid, L-ascorbic acid derivative, and the like The effect of improving the conversion of the skin is better than the original, and the anti-wrinkle effect, the anti-friction effect, the whitening effect, and even the anti-plaque action and the anti-relaxation effect by the active ingredients can be improved beyond the additive effect.

(plant extract or compound with skin conversion improving effect)

The above-mentioned plant extract or compound having a skin conversion improving effect can be exemplified by sesame, rehmannia, peach, licorice, cactus, wheat germ, wild strawberry, sage, mint, peppermint, houttuynia, and uncaria. Perilla, Poria, Japanese Camellia, Jujube, Indigo, Mutong, Tomorrow, Luohanbai, West Indian Cherry, European Hollyhock, Aloe, Ginkgo, Astragalus, Small Forsythia, Olive, Orange, Chamomile, Alfalfa, Grapefruit, Cinnamon , moon peach, mantle, white birch, carambola, sauerkraut, mulberry, tea, clove, carrot, Witch hazel, rose, Himalayan raspberry, fake leaf tree, pseudo gorse, peony root bark, horse chestnut, evening primrose, cornflower, eucalyptus, saxifrage, grapefruit, coix seed, orchid, lemon , Chinese milk vetch, rose hip, rosemary, cherry, staghorn, wolfberry, golden fruit, cnidium, bordeaux, ramie, eucalyptus, angelica, dwarf scent, corydalis, kansui, impatiens, forsythia , purple scorpion, myrrh, grass scorpion, stone pine, turmeric, medlar, fig, magnolia, white magnolia, white birch, big leafhopper, honeysuckle, hazelnut, peach kernel, jujube and other plant extracts, seaweed, green algae, Royal jelly, dried tangerine peel, carnitine, nicotinic acid amide, pyridoxine hydrochloride (vitamin B6), hyaluronic acid, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid , propanol diacid, vitamin A, glycyrrhizic acid derivative, allantoin, diclofenac, diphenylacetic acid, ibuprofen, ketoprofen, rosopprofen and the salts thereof In addition, one type of these may be used, or two or more types may be used in combination as appropriate. Further, among the plant extracts having the skin transformation improving effect, are plants of the cypress family (Rohan cypress, etc.), plants of the ginkgo family (ginkgo biloba), and plants of the citrus family (yellow, orange, grapefruit, grapefruit, Lemons, etc., extracts of plants of the genus Perilla (menthol, peppermint, perilla, rosemary, etc.), plants of the genus Houttuynia (Houttuynia cordata), and plants of Eucommia ulmoides (European chinensis, etc.) are suitable. Among them, Rohan cypress extract, Ginkgo biloba extract, Astragalus membranaceus extract, orange extract, Perilla extract, Houttuynia cordata extract, and Eucommia ulmoides tea extract have the saccharification reaction inhibition effect described later, and are in the present invention. Among them, a combination with L-ascorbic acid, a derivative of L-ascorbic acid, and the like is most suitable.

The aforementioned plant extract having a skin conversion improving effect or The preferred blending amount of the compound is relative to the skin external composition of the present invention, or the lotion, the facial cleanser, the cosmetic liquid, the lotion, or the cream contained in the cream blended with the composition. The amount of the ascorbic acid, the derivative of the L-ascorbic acid, and the one or more of the total of the one or more selected from the salt (the absolute amount) are usually 0.00001 parts by mass or more, preferably 0.0001 to 50% by mass. It is preferably blended in a range of 0.001 to 10 parts by mass, more preferably 0.01 to 1 part by mass. When it is lower than the lower limit of the aforementioned blending amount or higher than the upper limit of the blending amount, the desired effect may be remarkably lowered or may become unsatisfactory.

Further, in the external composition for skin of the present invention, if a plant extract or a compound having a saccharification reaction inhibiting action described later is blended as needed, it is more preferable to use L-ascorbic acid or a derivative of L-ascorbic acid as an active ingredient and The effect of the salt-induced conversion of the skin can improve the anti-wrinkle effect, the anti-friction effect, the whitening effect, the anti-plaque effect, and the anti-relaxation effect caused by the active ingredients beyond the additive effect.

(plant extract or compound having inhibition of saccharification reaction)

The plant extract or compound having the saccharification reaction inhibiting action may be exemplified by rapeseed, millet grass, stalk cold water hemp, lobular scorpion, dragon bud grass, Jingle fruit, Mutong, young cabbage fruit, and sleeping. Eggplant, Rohan cypress, catechu, cork oak, Gynostemma pentaphyllum, dentate fennel, Witch Hazel, Aristotle, Epimedium, Polygonum cuspidatum, Ginkgo biloba, Japanese wintergreen, Strawberry, Shandan, Halo, False Yellow bell wood bark, red leaf maple, banshan Dan, fennel, American witch hazel, dwarf holly, turmeric, plum, narrow leaf scorpion, short-horned yak yam, camp real, purple rudbeckia, acanthopanax, gorse, dragon Gallbladder, elderberry, micro-pulse holly, fan coconut, scutellaria, berberine, yoghurt, oatmeal, scalloped rice bran, pig's head, rose lily, yellow leeks, ghost lily, oregano, orange, pumpkin seeds, card Bark Bark, Deer Lily, Guarana, Luoshen, Asarum, Rehe Dandelion, Campanulaceae, Sorrel, Haizhou Changshan, Feidaotong, Zhejiang Lily, Walnut, Bilberry, Papua, Saga Brown Algae, Pomegranate, Sweet Potato , Sarshagen, wild hawthorn, mountain pepper, Su, wing bean, mosquito genus, peony, palm leaf rhubarb, white mountain chrysanthemum, medlar, mountain white orchid, plantain, centella, buckwheat, musk lily, broken rice bran, vine (Davilla rugosa), noble lily, branch Cordia salicifolia, clove, narrow-leaved senna, thunder root, daisy, dill, chain hook, mountain chrysanthemum, iron cannon lily, hanging chain hook, raspberry, peach kernel, houttuynia, spine Pear, Eucommia tea, tomato, Potentilla, wrinkle sorrel, elderberry, nasturtium, wild chrysanthemum, mint, Bodo lily, arborvitae, Ohno, passionflower, passion fruit, Brazilian root, Jackfruit, scented cherry, sunflower, python, scented lily, large flower scallions, betel nut, coltsfoot, cowpea, scented flower cohosh, showa grass, hibiscus, fragrant nan, pine, saber vertebrate, horse Tea, white lily, cockroach, eucalyptus, wild papaya, sea bream, willow, valerian, sedge, mountain lily, leeks, marry, litchi seeds, Lijiang lily, croquet, croquet Rose strawberry, apple unripe fruit, elm flower, red oak, lettuce Lemon, lemongrass, thyme, lemon leaf verbena, lemon balm, rose hip, red rose, rosemary, short thorn wild rose, bay laurel, Rhodiola, Mexican hematoxy, mantle, Chinese milk vetch, persimmon leaf, Extracts of licorice leaves, black soybean seed coats, purple rice seeds, moon peach leaves, fine leaf lily, western willow, eucommia leaves, leaves of tomorrow leaves, seaweed extracts such as seaweed, sea radish, and staghorn seaweed, Extracts of green coffee beans, sweet potato shochu, agaric mycelium, etc., and equol, isoflavones, 1,4-anthracene, 1-amino-2-hydroxymethyl hydrazine, 4-amine Phenolic, 1,3,5-trihydroxybenzene, citric acid, 3,4-dihydroxyphenylacetic acid, caffeic acid, ifenprodil, 6-hydroxy-2,5,7,8-tetra Methyldihydrobenzopyran-2-carboxylic acid, 6-hydroxyindole, 7-hydroxy-4,6-dimethyl azlactone, α-lipoic acid, 4-hydroxychalcone, propolis protein hydrolysis Hydroxy stilbene, oxindole, carnosine, etc., aminoguanidine, erythromycin sodium, ergothiol, resveratrol, 3,3 ' , 5,5 ' -tetrahydroxystilbene , salicylic acid, norazine, bromide Hydrogenate, mustard acid, tocopheryl nicotinic acid, nicotinic acid decylamine, dihydroguaiaretic acid, anthocyanin, mannitol, hydrolyzed casein, hydrolyzable tannin, catechol, green Chlorogenic acid such as ortho acid, isochlorogenic acid, neochlorogenic acid, cryptochlorogenic acid, coffee quinic acid, cyanidin, oryzanol, proanthocyanidin oligomer, glucosyl rutin Wait. Among the above ingredients, belladonna, arborvitae, catechu, ginkgo, dwarf holly, sassafras, orange, pumpkin seeds, katuba bark, phenanthrene, glucosyl rutin, bilberry, perilla, buckwheat leaves, grapes Rata (Davilla rugosa), Houttuynia cordata, Vipera, Showa grass, Wood scorpion, Ryukyu yam, Ryukyu roseberry, apple unripe fruit, persimmon leaf, licorice leaf, moon peach leaf, extract of Eucommia ulmoides, and female Phenol, isoflavone, ifenprodil, pearl protein hydrolysate, catechol, caffeic acid, and betulin, which are effective for increasing L-ascorbic acid, L-ascorbic acid derivatives and such The anti-wrinkle effect, the anti-friction action, the whitening effect, and even the anti-plaque action and the anti-relaxation effect by the salt can be used as a better combination in the present invention. Further, among the plant extracts having the saccharification reaction-inhibiting action, plants of the genus Cypress (Rohana, etc.), plants of the Ginkgo family (Ginkgo biloba), plants of the citrus family (yellow, orange, lemon, etc.), perilla Extracts of plants (perilla, rosemary, etc.), plants of the genus Houttuynia (Houttuynia cordata), and plants of Eucommia ulmoides (European chinensis, etc.) are more suitable. Among them, the extract of Luohanbai, Ginkgo biloba extract, Astragalus membranaceus extract, orange extract, Perilla extract, Houttuynia cordata extract, and Eucommia ulmoides leaf extract have the effect of skin transformation improvement, and in the present invention, The combination with L-ascorbic acid, a derivative of L-ascorbic acid, and the like is most suitable. In addition, when a plant extract or a compound having a saccharification reaction inhibitory action is used in combination with one or more selected from the group consisting of L-ascorbic acid, a derivative of L-ascorbic acid, and the like, the saccharification can be effectively suppressed. The formation of advanced glycation end products (AGEs), in addition to reducing or even inhibiting the deposition of poor AGEs on the skin tissue, while in the process of producing AGEs, due to the intramolecular and molecular properties of collagen Forming disorderly cross-linking, and reducing or even inhibiting physical and physiological changes (modification) caused by collagen, thereby effectively preventing or even improving wrinkles, rough skin, dullness, or firmness Reduces the aging of other skin types. In addition, when a plant extract having a saccharification reaction inhibitory action is used in combination with one or more selected from the group consisting of L-ascorbic acid, a derivative of L-ascorbic acid, and a salt thereof, the following advantages are obtained: the blockage is caused by The odor and odor of the plant extracts further enhance the preservation stability.

The aforementioned plant extract having inhibition of saccharification reaction or The skin external composition of the present invention, or the lotion, the facial cleanser, the cosmetic liquid, the lotion, or the derivative of L-ascorbic acid and L-ascorbic acid contained in the cream, and the preferred blending amount of each of the compounds 1 part by mass of one or more of the above-mentioned salts is usually 0.0001 part by mass or more, preferably 0.001 to 50 parts by mass, more preferably 0.001 to 10 parts by mass, even more preferably It is blended in the range of 0.01 to 1 part by mass. When it is lower than the lower limit of the aforementioned blending amount or higher than the upper limit of the blending amount, the desired effect may be remarkably lowered or may become unsatisfactory.

Further, in the external composition for skin of the present invention, the above-mentioned plant extract or compound having a saccharification reaction inhibiting action is usually carried out in a stepwise manner for each unit composition in combination with the aforementioned plant extract or compound having a skin conversion improving action. The total amount of the substance is 0.01 to 1% by mass, and the total amount of one or more selected from the derivatives of L-ascorbic acid and L-ascorbic acid and the salt thereof is 1 to 10% by mass. In addition, in addition to L-ascorbic acid, a derivative of L-ascorbic acid as an active ingredient, and an effect of improving the conversion of the skin caused by the salt, the above-mentioned plant extract or compound having a skin transformation improving effect is The effects of the plant extract or compound having the saccharification reaction inhibition effect described above complement each other, and the anti-wrinkle action, the anti-friction action, the whitening effect, the anti-plaque action, and the anti-relaxation effect can be remarkably enhanced until the additive effect is exceeded.

B. Basic cosmetics

The skin external composition of the invention can be applied to basic cosmetics and color In the field of cosmetics such as makeup cosmetics, in particular, when blended into a base cosmetic such as a lotion, a facial cleanser, a cosmetic liquid, an emulsion, or a cream which is directly applied to the skin, an excellent anti-aging effect can be expected. Hereinafter, a representative basic cosmetic of the external composition for skin of the present invention can be used.

<lotion>

The skin external composition of the present invention, as described above, may be an aqueous medium as a base, and may further be blended with ethanol and a moisturizing agent to form a lotion. The lotion can be used to replenish moisture or moisturizing ingredients to the stratum corneum of the skin, and can be used to assist the physiological effects of the skin. Specific examples of the lotion include a cleansing lotion, astringent lotion, a soft lotion, a multi-layer lotion, and the like, and also include a skin lotion, a body lotion, a hand lotion, a moisturizing lotion, and the like.

(moisturizer)

The moisturizing agent used in the lotion of the present invention includes the following. That is, glycerin, ethylene glycol, propylene glycol, 1,3-butanediol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1 can be exemplified , 3-propanediol, trimethylolpropane, pentaerythritol, diglycerin, polyglycerol, diethylene glycol, triethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, 1,2-pentanediol 1,2-hexanediol, 1,2-heptanediol, isoprenediol, isopentyl glycol, hexanediol, triglycerin, 2-methylpropenyloxyethylphosphocholine , tetrahydrofurfuryl alcohol, polyoxyethylene (POE) tetrahydrofurfuryl alcohol, polyoxypropylene (POP) butyl ether, POP. POE butyl ether, trimeric propylene glycerol Ether, POP glyceryl ether, POP glyceryl ether phosphate, POP. POE pentaerythritol ether, ethylene glycol. Polypropylenes such as propylene glycol copolymer, phytantriol, erythrozanose, ethylene glycol monomethyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, diethylene glycol monomethyl ether , triethylene glycol monoethyl ether, monoglyceryl ether ether, diethylene glycol monoethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. Sugar alcohols such as diol alkyl ethers, sorbitol, xylitol, butyl alcohol, mannitol, maltitol, maltotriol, maltotetraol, hydride of starch hydrolysate, sucrose , rhamnose, glucose, fructose, galactose, mannose, isoerythrocyanin, xylose, arabinose, trehalose, ribose, deoxyribose, maltose, maltotriose, maltotetraose, trehalose , saccharide derivatives of trehalose such as lactose, raffinose, gluconic acid, glucuronic acid, glucosyl trehalose, maltosyl trehalose, maltotriosyl trehalose, maltotetraose-based trehalose, sulfuric acid Fucose, dextrin, cyclodextrin, and ring {→6)-α-D-glucopyranoside-disclosed in International Publication No. WO 02/10361 3)-α-D-gluconoside-(1→6)-α-D-glucoside-(1→3)-α-D-glucoside-glycoside-(1→} Tetra-tetrasaccharide (cyclotetragerosylnigelose), which has a ring {→6)-α-D-glucopyranoside-(1→4)-α-D-grape as described in Japanese Laid-Open Patent Publication No. 2005-95148 Cycloglycoside-(1→6)-α-D-glucoside-(1→4)-α-D-glucoside--(1→}-structured cyclic tetrasaccharide (cyclomaltosyl maltose: Cyclomaltosylmaltose), pullulan, heterologous sugar, xylitol glucoside, sugar, lysine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptamine Acid, lysine, glycine, Alanine, aspartic acid, glutamine, lysine, serine, cysteine, cystine, tyrosine, valine, hydroxyproline, aspartic acid, glutamine NMF components such as acid, sodium glutamate, hydroxy lysine, arginine, ornithine, histidine, pyrrolidone carboxylic acid, etc., sodium lactate, uric acid, sodium pyrrolidonecarboxylate, etc. Natural moisturizing ingredients), glycogen, dextran, locust bean gum, xyloglucan, sputum, carrageenan, pectin, mannan, carterin, amber polyglucose, galactose, Mucopolysaccharides such as arabinogalactan, dermatan sulfate, keratan sulfate, chondroitin, chondroitin sulfate, mucopolysaccharide, keratin sulfate, chitin, chitin, heparin, heparin sulfate, hyaluronic acid, etc. Or a hydrolyzate of such a mucopolysaccharide, a soy protein decomposing peptide, a wheat protein decomposing peptide, a hydrolyzed wheat protein, a casein decomposing peptide, a palmitoyl oligopeptide, or the like, a sulfhydryl peptide, decane Proteins such as peptides, chitin-decomposing peptides, hydrolyzed chitin, silk or collagen/ a peptide or such a hydrolyzate, a hydrolyzed hyaluronic acid, a water-soluble polymer substance such as a hydrolyzed eggshell membrane, a salt thereof, a lecithin derived from soybean, a yolk, etc., a phospholipid glycerin, a phospholipid osmolar, a phospholipid silk Amino acids, phospholipids, ethanolamines, phosphatidic acids, sphingomyelins, phospholipids, sphingolipids, olive oil, jojoba oil, squalane, etc., dimethyl polyoxane, methylphenyl hydrazine Culture supernatants such as oxane, lactic acid bacteria/Bifidobacter, etc., royal jelly extract, yeast extract, eggshell membrane protein, burdock mucin, hypotaurine, galactose arabinose Sugar, sesame lignan glycoside, albumin, whey, choline chloride, choline, placenta extract, coix seed essence, peony essence, seaweed essence, gentian essence, saxifrage Essence, Perilla Huazhong, Hydrolyzed Rice Bran Essence, Quinoa Extract, Trimethylglycine, N-Methyl-L-Leserine, Nicotinic Acid, Astragalus Essence, Tea Essence, Leigonggen Essence, Mulberry Essence, Alcaligenes Polysaccharide, White Mustard Seed Hydrolysis Essence, Acetyl Hyaluronate, European Hollyhock Essence, Angelica Essence, Aloe Vera Essence, Roche Rose Essence, Deoxyribonucleic Acid, Dip Fruit Melon Essence, Carrot Essence, Houttuynia Essence, Oolong Tea Essence, Wheat Germ Essence, Wood Disaccharide Mixture, Mutong Essence, Astragalus Essence, Hypericum erectum Essence, Pueraria Essence , serum, cherry leaf extract, peony essence, cellar essence, West Indian cherry essence, hawthorn extract, alpine velvet extract, almond fruit extract, glucosyl hesperidin, yellow vesicle root Essence, Western Mint Essence, Rehmannia Essence, Mevalorolactone, Tomorrow Leaf Essence, Ginkgo Essence, Essence Essence, Hydrolyzed Black Bean Essence, Thyme Thyme Extract, Coptis Essence, Gland嘌呤Glycoside monophosphate, adenine nucleoside trisodium phosphate, dl-α-tocopherol, DL-malate, γ-amino-β-hydroxybutyric acid, arhatin extract, asparagus extract, sorrel extract , Avocado Essence, Apricot Juice, Mussel Liver Sugar, Inositol, Boxing Extract, Biting Cat Essence, Yujin Essence, Bear Fruit Essence, Curry Essence, False Leaf False Blue Leaf Essence, Ethyl Glucoside, Dahua Ziwei Essence, Ape Essence, Stinging Mango Flower Essence, Olive Leaf Essence, Oyster Essence, Cattail Essence, Kam's Essence, Came Seed Extract Liquid, radish essence, raspberry essence, kiwi essence, guava essence, medlar essence, Vickers bear bamboo essence, Kushen essence, glycolic acid, grapefruit essence, clematis essence Liquid, green algae essence, Cape of Good Hope Aloe Vera Essence, Yak Seedling Essence, Coffee Essence, 2-(2-Hydroxyethoxy)ethyl succinate, Rice Bran Extract Hydrolysate, Collagen/Tripeptide, Asarum Essence, Amber醯 base-deficient collagen, wild hawthorn essence, mountain lentil essence, cyanocobalamin, seaweed essence, Japanese eucalyptus essence, dimethyl sterol/hyaluronic acid condensation solution, mosquito grass essence, calamus essence Liquid, white birch essence, silk extract, silk powder, honeysuckle essence, carambola leaf essence, strawberry juice, ivy essence, western wild mountain essence, infusion flower essence, sauerkraut essence, mulberry Skin Essence, Sorbitol Fermented Polysaccharate, Soy Essence, Jujube Essence, Japanese Camellia Essence, Daisy Extract, Terminalia Essence, Raspberry Essence, Peach Kernel Essence, Spruce Essence, Corn Essence , tomato juice, wild rose essence, hibiscus essence, lupin essence, malt root essence, cape grass essence, lotus seed lactic acid fermentation broth, parsley essence, rose essence, witch hazel essence, 蔷Essence, wall grass essence, coastal crab foot narcissus essence, hawthorn extract, eucalyptus essence, plant liver sugar, fake leaf tree essence, impatiens essence, poly aspartate sodium citrate, large Oregano Essence, Lily Essence, Blue Water Extract, Horse Chestnut Extract, Elastin, Natural Ceramide (Type 1, 2, 3, 4, 5, 6), Hydroxysteroid, Suspected Ceramides, sphingolipids, ceramides, glycosides, and glycosaminoglycines contain neurosteroids such as deep-sea water, alkali-only hot spring water, polyoxyethylene methyl glucoside, and dl-pyrrolidone carboxylate. Sodium, L-oxyproline, acetaminophen, taurine, and the like.

In particular, it is blended with the external composition for skin of the present invention. In the case of a lotion, the skin moisturizing effect is excellent, and one or two or more selected from L-ascorbic acid, a derivative thereof, and the like are combined, and the skin roughness improving effect can be more effectively exhibited. Humectants are preferred. That is, using glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, 3-methyl-1,3-butanediol, pentaerythritol, diglycerin, polyglycerin, diethylene glycol, three Ethylene glycol, polyethylene glycol, dipropylene glycol, trehalose, ceramide, 2-methylpropenyl oxyethylphosphocholine, hyaluronic acid, chondroitin sulfate, hydrolyzed hyaluronic acid, yeast extract, coix seed extract One or more selected from the group consisting of liquid, peony essence, seaweed essence, gentian essence, trimethylglycine, N-methyl-L-serine, nicotinic acid amide, and royal jelly extract Good as a moisturizer.

The humectant is usually used in an amount of 0.0001% by mass or more, preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass, still more preferably 0.1 to 10% by mass per unit mass of the lotion of the present invention. Under blending.

Further, in the lotion according to the present invention, one or two or more selected from the astringents, keratolytic agents, softening agents, and surfactants described above may be blended in accordance with the purpose and function.

(astringent)

Examples of the astringent include citric acid, tannic acid, ethoxylated propionic acid, isomethic acid, amino gibberellic acid, ethoxy acetic acid, ethoxypropionic acid, isoaminic acid, and epoxy groups. Oleic acid, oleic acid, aminobutyric acid, erucic acid, oxalic acid, formic acid, arachidonic acid, glucuronic acid, iduronic acid, Crotonic acid, chloroisocrotonic acid, isocrotonic acid, acetic acid, dihydrolipoic acid, tartaric acid, ethyl crotonic acid, diphenylacetic acid, dimethoxy phthalic acid, ethyl hydroxybutyric acid, succinic acid, hard Fatty acid, stearic acid, sorbic acid, glyceryl acid, thyroxine, citric acid, tropic acid, lactic acid, hydroxyisobutyric acid, hydroxy gemic acid, pyruvic acid, butyl acetic acid, butyl hydroperoxide, hydrazine Oxalic acid, propiolic acid, propionic acid, bromoisophthalic acid, bromoisotylic acid, bromopropionic acid, hexane acid, hexenoic acid, celery acid, leucovoric acid, heptanoic acid, allenoic acid, malayan Amino acid, mycolic acid, myristic acid, methacrylic acid, methyl oxalic acid, methyl thioacetic acid, methyl butyric acid, mevalonic acid, beeswavic acid, indole acetic acid, iodoacetic acid, lauric acid, anti-caries Acid, ricinoleic acid, linoleic acid, linoleic acid, aconitic acid, oxalic acid, ketoglutaric acid, adipic acid, calcein, carboxyphenylacetic acid, ethoxylated succinic acid, pyridine tricarboxylate Acid, sulphuric acid, isomeric sulphate, glutaconic acid, glutaric acid, isocitric acid, crocetin, succinic acid Phthalic acid, fumaric acid, isopyridine dicarboxylic acid, diethylenetriamine pentaacetic acid, isophthalic acid, citramalic acid, dinicotinic acid, itaconic acid, dibromosuccinic acid, dichlorosuccinic acid, Ethylmalonic acid, dimethyl succinic acid, oxalic acid, dipicolinic acid, pyromellitic acid, geranyl acid, barium tricarboxylic acid, benzene hexacarboxylic acid, benzene pentacarboxylic acid, maleic acid, malonic acid, Zhongkang acid, meso-tartaric acid, middle oxalic acid, methyl isophthalic acid, methyl succinic acid, methylmalonic acid, decyl succinic acid, pyromellitic acid, peroxyphthalic acid, malic acid, pyridine Formic acid, leukotriene bromide benzoic acid, amino cinnamic acid, isopropyl cinnamic acid, decylamine phthalate, arecoline acid, carboxy cinnamic acid, cinnamic acid, gallic acid, gallic acid, tranexamic acid , nitrocinnamic acid, hydroxy cinnamic acid, methoxycinnamic acid, hydroxyhydrocinnamic acid, phenyl laurel Phytic acid, turmeric citric acid, orotic acid, azlactone, quinic acid, hydroxyproline, cholesteric acid, brevisic acid, carnosine, carbazole acetic acid, quinoline carboxylic acid, quinolinic acid, quinolin Porphyrinic acid, coumaric acid, chlorophenoxyacetic acid, chenodeoxycholic acid, choline acid, bile acid, mountain acid, dihydroorthoic acid, amber decanoic acid, thiophene carboxylic acid, tetrahydrofolate, Dehydrocholic acid, decenoic acid, hydroxypyrocarboxylic acid, hydroxypyro-dicarboxylic acid, hydroxyphenylacetic acid, hydroxyphenylpropionic acid, biphenyldicarboxylate, black uric acid, phenylglycolic acid, rat bile Acid, methyldopa, methylphenylacetic acid, methylfurancarboxylic acid, methyl red, mefenamic acid, lysergic acid, lithocholic acid, lipoic acid, reserpine acid, retinoic acid, left-handed Pimaric acid, glycolic acid, salicylic acid, zinc p-phenol sulfonate, hollyhock, genus, chrysanthemum, iris, fennel, crape myrtle, orange, raspberry, guava, black currant, yak Miao, wild hawthorn, mosquito genus, peony, white birch, honeysuckle, wattle, ivy, thyme, thyme, tea, parsley, witch hazel, grape, cornflower Lemon, Chinese milk vetch, cellar, cinchona, red, linden, mandarin, juniper, rosemary, small forsythia, ginkgo, lemon balm, thorn flower, horse chestnut, sauerkraut, garlic , chamomile, thyme, mint, biting cat, pepper, ginger, sedge, monkey horse chestnut, lavender, carrot, mustard, laurel, pine, chuanxiong, elderberry, celery, alfalfa, peony, bayberry, surimi Grass, Pampas grass, persimmon, calendula, medlar, yellow gentian, coaster, orange, grapefruit, calamus, summer orange, yellow vanilla hibiscus, Brazilian pepper, eucalyptus, aronia, fragrant tea, rice, Sophora flavescens, Ginger, clove, walnut leaf, scutellaria, sage, rosemary, sage, berberine, cork, scutellaria, heavy medicine, dried tangerine peel, ginseng, rush, taksia, tannin, birch tar, etc. Extract, bee Gum, royal jelly, yeast extract, night primrose polysaccharide, oolong tea, alum, zinc chloride, zinc sulfate, aluminum sulfate, aluminum chloride, allantoin, aluminum hydroxychloride, allantoin, dihydroxy aluminum, pentoxide Alkali chloride, zinc oxide, zinc sulfide, zinc phenolsulfonate, sodium phenolsulfonate, organic complex salts of aluminum and zirconium, and the like.

The astringent agent is usually used in an amount of 0.0001% by mass or more, preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass, still more preferably 0.1 to 10% by mass, per mass of the lotion of the present invention. Under blending.

In particular, when the skin external composition of the present invention is blended into a lotion, it is desirable to use an acid agent such as citric acid, succinic acid, tartaric acid, retinoic acid or malic acid which is excellent in astringent effect, and yellow Aluminum compound such as alcohol, zinc chloride, aluminum powder, aluminum sulfate, alum and modified alcohol, ethanol, hollyhock essence, rabbit chrysanthemum essence, boxing extract, biting cat essence, iris root essence , fennel essence, oolong tea essence, ethanol, big flower Ziwei essence, small forsythia essence, orange flower water, orange juice, artemisia extract, raspberry essence Liquid, geraniol, yak seedling essence, wild hawthorn essence, mosquito grass essence, peony essence, white birch essence, honeysuckle essence, jingjing essence, ivy essence, western wild mountain essence Liquid, Thyme Thyme Extract, Tea Essence, Houttuynia Essence, Parsley Essence, Witch Hazel Essence, Grape Leaf Essence, Pine Essence, Lemon Balm Essence, Cornflower Essence, Ai Essence , More lemon juice, milk vetch Essence, Essence Burnet selected one or two kinds of Astringent is good.

(keratin softener)

Examples of the keratin softener include ethanol, isopropanol, propanol, butanol, polyethylene glycol, benzyl alcohol, phenylethyl alcohol, propylene carbonate, hexyldodecanol, and dimethyl azine. , dimethyl acetamide, dimethylformamide, triethanolamine, diisopropyl adipate, ethyl laurate, lanolin, fatty acid dihydroxyalkyl guanamine, urea, sulfur, isophthalic acid Diphenol, phytic acid, lactic acid, lactate, glycolic acid, sodium hydroxide, potassium hydroxide, and the like. In particular, when the lotion for the anti-aging skin external composition of the present invention is blended, urea, sulfur, ethanol, lactic acid, glycolic acid, salicylic acid, sodium sulfate which is excellent in the use of the keratin softening effect is used. One or two or more selected ones are preferred.

(softener)

In terms of softening (softening) agent, oily components similar to sebum are preferred, and in terms of oily components, for example, hemp seed oil, muluberry fruit brown fat, rapeseed seed oil, star fruit coconut fat, and flax seed oil, Argan nut oil, apricot kernel oil, sea buckthorn oil, eucalyptus seed oil, eucalyptus oil, Atlantic chestnut oil, mustard oil, Japanese eucalyptus seed oil, mangosteen seed oil, caraway seed oil, almond oil, Stone chestnut oil, Kronberg abini Sika seed oil, cranberry seed oil, walnut seed oil, black currant seed oil, bilberry seed oil, rice germ oil, five-leaf pine seed oil, camellia oil, juniper seed oil, Oxidized corn oil, shea oil, juniper oil, white flower lupine Seed oil, hydrogenated avocado oil, hydrogenated olive oil, hydrogenated tallow, hydrogenated soybean oil, hydrogenated rapeseed seed oil, hydrogenated milk fat, hydrogenated palm kernel oil, hydrogenated palm oil, hydrogenated castor seed oil, hydrogenated jojoba oil, hydrogenated Wild vegetable oil, hydrogenated coconut oil, horse milk fruit oil, ostrich oil, wild passionflower seed oil, tea seed oil, Japanese camellia oil, cranberry seed oil, quaint aso oil, porpoise, milk fat, oyster sauce , Barba oil, peanut oil, Pistacia seed oil, vinegar oil, sunflower seed oil, mulberry seed oil, grape seed oil, partially hydrogenated perilla oil, partially hydrogenated horse oil, pseudo gorse seed oil, broccoli seeds Oil, loofah seed oil, American pumpkin seed oil, Haematococcus pluvialis oil, cloudberry seed oil, pine seed oil, mango seed fat, mango seed oil, oyster sauce, bitter seed oil, peach kernel oil, wild vegetable oil, oil tea Oil, European raspberry seed oil, apple seed oil, borage seed oil, rosehip oil, Moringa seed oil, macadamia oil, castor seed oil, olive oil, almond oil, cocoa butter, oyster sauce, coconut oil, Palm oil Wood wax, jojoba oil, grape seed oil, avocado oil, safflower oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, eucalyptus seed oil, white mango seed oil, almond oil, peppermint oil, tea tree, corn Oil, rapeseed oil, sunflower oil, linseed oil, cotton oil, soybean oil, groundnut oil, rice bran oil, cocoa butter, shea butter, fennel oil, perilla oil, chamomile oil, radish oil, chanterelle oil, egg Butter, tallow, horse fat, fish oil, sea turtle oil, plant oils and fats such as Atlantic chestnut oil, lacquer fruit wax, large flower frangipani wax, orange fruit wax, orange flower wax, hydrolyzed jojoba ester , palm wax, candelilla wax, wrinkle crown daffodil wax, rice bran wax, bay berry wax, acacia wax, night scented wax, beeswax, whale wax, Atlantic chest thorn oil, lanolin, rice wax, Waxes such as montan wax and paraffin, Eicosane, isododecane, isohexadecane, diethylhexylcyclohexane, pentahydro squalene, mineral oil, mobile paraffin, polyisobutylene, hydrogenated polyisobutylene, polybutene, squalane, squalene, Microcrystalline wax, ceresin, paraffin wax, petroleum jelly, paraffin wax, α-olefin oligomer, hydrocarbon such as tetradecene, heterogeneous linoleic acid, tallow fatty acid, fatty acid (C14-28), fatty acid (C20- 40), hydrogenated coconut fatty acid, palmitic fatty acid, 10-hydroxy citric acid, tiller fatty acid (C14-28), tiller fatty acid (C12-31), azelaic acid, lanolinic acid, myristic acid, palmitic acid, stearic acid Acid, diced acid, lanolin fatty acid, linoleic acid, linoleic acid, lauric acid, oleic acid, isostearic acid, undecylenic acid, 1,2-hydroxystearic acid, palmitoleic acid, erucic acid, Natural and synthetic fatty acids such as docosahexaenoic acid, decyl pentenoic acid, isohexadecanoic acid, protopinoic acid, isodecanoic acid, 2-ethyl hexane acid, and the like, and C12-16) alcohol, (C14-22) alcohol, (C20-22) alcohol, (C20-40) alcohol, (C30-50) alcohol, rapeseed seed sterol, isocetyl alcohol, isopropanol, xin Glycol, rice gluten , hydrogenated rapeseed oil, cetyl alcohol, stearyl alcohol, hexyl decyl alcohol, octyldodecanol, lauryl alcohol, octanol, myristyl alcohol, oleyl alcohol, cetearyl alcohol, arachidyl alcohol, mountain Sterol, jojobaol, stilbenol, squalyl alcohol, squalyl alcohol, isostearyl sterol, cetyl alcohol, cholesterol, phytosterols, lanolin alcohol, hydrogenated lanolin alcohol, palmitol, 2- Natural and synthetic higher alcohols such as mercaptotetradecyl alcohol, (C12-15) alkanol polyether-9 carboxylic acid isopropyl ester, pyrrolidone carboxylic acid octyldodecyl ester, pyrrolidone carboxylic acid mint Brain ester, pyrrolidone carboxylic acid lauryl ester, PEG-2 isodec-7-carboxylate cetyl ester, adipic acid di PPG-3 myristyl ester, adipic acid di PPG-2 nutmeg - 10, diisopropyl adipate, Diheptyl undecyl dicarboxylate, avocado fatty acid ethyl ester, avocado oil fatty acid butyl ester, benzoic acid methyl glucose-20, ethyl isostearate, (isostearic acid/succinic acid) Castor seed oil, hydrogenated castor oil of isostearic acid, shark liver isostearate, hexyl decyl stearate, (isostearic acid / beeswax / succinic acid) castor seed oil, Isodecyl isononanoate, isotridecyl isononanoate, isodecyl isononanoate, octyl isodecanoate, cetyl isodecanoate, sucrose isobutylate acetate, octyl sesquienoate , butyl ethyl propane ethanohexane propane diol, octyldodecyl erucic acid, oleic acid oleyl ester, alkyl octanoate (C14, 16, 18), (octanoic acid / stearic acid /adipic acid) glyceride, cetyl octanoate, cetyl octanoate, hexyl decyl octylate, ethyl ester of olive fatty acid, oleyl oleate, (mercapto / suet Acid) glyceride, (mercapto/paraffin/coconut fatty acid) glyceride, (mercapto acid/stearic acid/succinic acid) triglyceride, cetyl sorbate, triiso-citric acid Lipid raft, triisooctyldodecyl citrate, (citric acid / Acid/linolenic acid/oleic acid) glyceride, isostearyl succinate diglyceride, diethoxyethyl succinate, dioctyl succinate, rice bran oil fatty acid phytosterol ester, acetic acid sixteen Alkyl ester, farnesyl acetate, lanolin acetate, benzoic acid acetate, propylene glycol diisostearate, dimerized dilinoleyl diisostearate, neopentyl glycol diisostearate, two Ethylhexenoic acid neopentyl glycol, dioleic acid PEG-18 castor seed oil, bis(decyl.succinate) butanediol, isosorbide disorbate, di(indenyl acid). Succinic acid) polyethylene glycol, distearyl citrate dicocoyl decyl pentaerythritol, polyethylene glycol distearate, PG-20 methyl glucose distearate, pentaerythritol distearate, two Neopentanoic acid diethylpentanediol, dipentanoic acid Pentyl diol, polyethylene glycol dioctanoate, fatty acid (C10-30) (cholesterol / lanosterol), fatty acid (C12-18) cetyl, dilauric acid glycol, two linseed oil Diisopropyl acid ester, hydrogenated rosin acid pentaerythritol, hydrogenated rosin acid methyl ester, (hydrogenated rosin / diisostearic acid) glyceride, ethyl hexyl stearate, stearic acid stearic acid Wax, octyldodecyl stearate, dibutyloctyl sebacate, dioctyllinolenic acid octyldodecyl/PPG-3 myristyl ether, dimerized linseed oil Acid di(isostearate/phytosterol), dimerized linolenic acid dicetene, dimerized two linoleic acid hydrogenated castor seed oil, dimerized two linoleic acid stearin/PPG-3 nutmeg Diether, dimerized linolenic acid dimerized dilinyl ester, dimerized dilinoleic acid dimerized dilinyl bis (behenyl alcohol/isostearate/phytosterol ester), dimerization Sesame oil (phytosterol ester/isostearate/cetyl/stearate/behenyl alcohol), dimerized dilinyl hydrogenated rosin condensate, dialkyl carbonate (C14,15), carbonic acid Ethylhexyl, dioctyl carbonate, Pentaerythritol isostearate, pentaerythritol tetraoctanoate, polyglycerol-10 of dodecane (mercapto acid/stearic acid), diiso-cepyl dodecanedioate, dioctyldodecanoate Di-based ester, glyceryl triisostearate, erythritol triethyl hexanoate, di-trimethylolpropane triethyl hexane, tricaprylin, trioctyl trioctyl Propane, ternary fat, tris(mercapto acid/stearic acid) glyceryl, tris(mercapto acid/stearic acid/stearic acid) glyceryl, tris(mercapto acid/stearic acid/meat Myristic acid/stearic acid) glyceryl, tri-fatty acid (C8-12) glyceride, glyceryl tristearate, glyceryl tripalmitate, glyceryl tripalmitate, glyceryl trihydroxystearate, three hawthorn Alcohol ester, dimeric hydroxystearic acid dipentaerythritol, three nutmeg Acid glyceride, alkyl lactate (C12-15), ethyl lactate, octyldodecyl lactate, butyl lactate, menthol lactate, isodecyl neopentylate, neopentane Acid myristyl ester, octyl decanoate, cholesteryl decanoate, ethylhexyl palmitate, cetyl palmitate, bisdiglyceryl polydecyl adipate-1, bis Glyceryl polydecyl adipate-2, (hydroxystearic acid/isostearic acid) dipentaerythritol, ethylhexyl hydroxystearate, octyl hydroxystearate, hydrogenated stearic acid hydroxystearic acid Oil, (hydroxystearic acid/stearic acid/rosin acid) dipentaerythritol, hydroxystearic acid phytosterol ester, ricin seed fatty acid PPG-5.5, castor seed fatty acid methyl ester, propionate myristyl ester, Bismuth fatty acid (C12-31) cholesterol ester, hexahydroxystearic acid dipentaerythritol, hexa(hydroxystearic acid/stearic acid/rosin acid) dipentaerythritol, heptanoic acid stearin, (sebacic acid/icosane) Diacid) glyceride, jojoba ester, jojoba fatty acid isopropyl ester, macadamia fatty acid ethyl ester, macadamia fatty acid cholesterol ester, Xia Wei Fruit fatty acid phytosterol ester, dioctyl maleate, diethyl hexyl syringyl malonate, hexyl decyl methyl myristyl propionate, citronellyl methyl crotonate , white mangosone lactone, white mango seed oil fatty acid octyl dodecyl ester, (coconut oil fatty acid / citric acid / lactic acid) glyceride, coconut oil fatty acid thiol ester, cholesterol tyrosinate, dihydrocholesteryl butyrate Ester, lanolin fatty acid octyldodecyl ester, lanolin fatty acid cholesterol ester, octyldodecyl ricinoleate, diethylhexyl malate, trioleyl phosphate, tri-hexadecyl phosphate, Triethyl 2-ethylhexanedicarboxylate, cetyl 2-ethylhexanecarboxylate, neopentyl glycol di-2-ethylhexanecarboxylate, isopropyl myristate, butyl myristate Ester, isopropyl palmitate, stearic acid Ethyl ester, octyl palmitate, isocetyl isostearate, butyl stearate, ethyl linoleate, isopropyl linoleate, ethyl oleate, myristic acid whale Wax, isostearic acid myristic acid, isostearyl palmitate, octyldodecyl myristate, diethyl sebacate, diisopropyl adipate, isobutyl neopentanoate Ester, tris(decyl.succinate) glyceride, tris-2-ethylhexanecarboxylic acid trimethylolpropane, triisomethylstearate triisostearate, pentaerythritol tetrakis(2-ethylhexacarboxylate), Cetyl mercaptoate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, glycerol trimyristate , stearic acid stearin, decyl oleate, cetyl ricinoleate, isostearyl laurate, isotridecyl myristate, isocetyl palmitate, octyl stearate , stearic acid isocetyl, isodecyl oleate, octyldodecyl oleate, octyldodecyl linolenate, isopropyl isostearate, 2-ethylhexane acid Stearyl ester, 2-B Stearic acid sulfonate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dioleate, propylene glycol disorbate, bis(fluorenyl) . succinyl) propylene glycol, tris(decyl.succinic acid) glycerol, propylene glycol dimercaptoate, neopentyl glycol dipentyl glycol, neopentyl glycol dioctanoate, tridecyl acid Glyceryl ester, tri-undecyl glyceride, triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, hexyl ruthenium neodecanoate Base ester, octyldodecyl neodecanoate, isostearyl isostearate, octyldecyl isostearate, polyglyceryl oleate, polyglyceryl isostearate, dipropyl carbonate, Dialkyl (C12-18) carbonate, triisoheptyl citrate, triisoaphylyl citrate, triisooctyl citrate, milk Acid lauryl ester, myristyl lactate, cetyl lactate, octyl decyl lactate, lactic acid lanolin, triethyl citrate, triethyl citrate, citrate Butyl ester, trioctyl citrate, diisostearate malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, hydrazine Diisopropyl diacrylate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesterol oleate, iso-hard Fatty acid phytosterol ester, oleic acid phytosterol ester, 12-stearyl hydroxystearic acid isocetyl, 12-stearyl hydroxy stearate, 12-stearyl hydroxyl hard Esters of isostearyl sulphate, hexyl decyl dimethyl octanoate, isopropyl ester of lanolin fatty acid, liquid lanolin, reduced lanolin, sorbed purified lanolin, lanolin acetate, acetic acid Wool such as liquid lanolin, hydroxy lanolin, polyoxyethylene lanolin, hard lanolin fatty acid, acetic acid (cetyl ethenyl) ester Phospholipids such as sphingomyelin, phosphatidic acid, lysolecithin, etc., such as lecithin, choline phospholipid, cephalin, phospholipid lysine, phospholipid glycerol, phospholipid creatinine, sphingomyelin, etc. a phospholipid derivative such as soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, dihydrocholesterol, lanosterol, dihydro lanosterol, bile acid, etc. Methylphenyl polyoxyalkylene, methylhydrogen polyoxyalkylene, octamethylcyclotetraoxane, stearyloxypolyoxyl, decamethylcyclopentaoxane, tetramethyltetrahydrocyclotetragen A fluorinated oil such as a fluorene-based oil, a saponin, a saponin, a perfluoropolyether, a perfluorodecalin or a perfluorooctane, such as a decane or a dodecamethylcyclohexaoxane. Agents, etc.

In particular, when the skin external composition of the present invention is blended into a lotion, it is excellent in softening effect, and can be used in combination with cetyl alcohol, lauryl alcohol, cetearyl alcohol, and hard. Lipid sterol, oleyl alcohol, behenyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, hexyl sterol and octyldodecanol, squalane, plant squalane, hexadecyl 2-ethylhexane Α-olefin oligomer, isotridecyl isononanoate, isodecyl isononanoate, cetyl isodecanoate, ethyl oleate, oleic acid oleyl, ethylhexyl palmitate, octane One or two or more softeners selected from alcohols and hydrogenated soybean phospholipids are preferred.

(surfactant)

Examples of the surfactant include sorbitan monolaurate, coconut oil fatty acid sorbitan, sorbitan distearate, sorbitan monostearate, sorbitan tristearate, and monoisostearyl Sorbitanic anhydride, sorbitan monooleate, sorbitan trioleate, sorbitan fatty acid ester, sorbitan monopalmitate, sorbitan sesquioleic acid, sorbitan sesquitty acid, Monolaurin polyoxyethylene sorbitan, monostearate polyoxyethylene sorbitan, ethylene glycol monostearate, ethylene glycol distearate, diethylene glycol distearate, B Glycol fatty acid ester, glyceryl monostearate, glyceryl distearate, glyceryl isostearate, polyoxyethylene glyceryl isostearate, polyoxyethylene glyceryl triisostearate, iso-hard Diglyceride fatty acid, glyceryl diisostearate, glyceryl triisostearate, diglyceryl triisostearate, propylene glycol monostearate, self-emulsified propylene glycol stearate, ricinoleic acid Glyceryl ester, propylene glycol ricinoleate, propylene glycol fatty acid ester, propylene glycol dioleate, propylene glycol laurate, Linoleic acid glyceride, diisopalmitic acid glyceride, sesquioleate, glycerol monooleate, glyceryl trimyristate, isopropyl ester of lanolin fatty acid, hexyl decyl dimethyl octanoate, Acetyl glyceride, triisooctanoic acid glyceride, di-2-heptyl undecanoic acid glyceride, pyroglutamic acid oleic acid glyceride, decyl monooleate, dipentaerythritol fatty acid ester, Stearic acid malic acid glyceride, lauric acid polyoxyethylene hardened castor seed oil, polyoxyethylene alkyl (12-14) ether (7E.O.), polyoxyethylene alkyl (12-14) ether (12E .O.) polyoxyethylene alkyl ether (20E.O.), polyoxyethylene lauryl ether, polyoxyethylene myristyl ether, polyoxyethylene cetyl ether, polyoxyethylene hexadecane ether , polyoxyethylstearyl ether, polyoxyethylene oleyl ether, polyoxyethylene oil cetyl ether, polyoxyethylene behenyl ether, polyoxyethylene octyl phenyl ether, polyoxyethylene fluorenyl Phenyl ether, polyoxyethylene alkyl (12,13) ether (10E.O.), polyoxyethylene octyldodecyl ether, polyoxyethylene cetylstearyl diether, sesquistearic acid Polyoxyethylene methyl glucoside, carboxylated polyoxygen Ethylene tridecyl ether, octane acid polyethylene glycol (4) polyoxyethylene nonylphenyl ether (14E.O.) mixture, polyoxyethylene lanolin alcohol, polyoxyethylene (5) lanolin alcohol, poly Oxyethylene (10) lanolin alcohol, polyoxyethylene (15) lanolin alcohol, polyoxyethylene (20) lanolin alcohol, polyoxyethylene (25) lanolin alcohol, polyoxyethylene (40) lanolin alcohol, poly Oxyethylene (hydroxyalkyl. lanolinol) ether (16E.O.), acetic acid polyoxyethylene lanolin alcohol, polyoxyethylene lanolin, polyoxyethylene. Reduced lanolin, polyoxyethylene sorbitol lanolin (40E.O.), polyoxyethylene polyoxypropylene reduced lanolin, polyoxyethylene polyoxypropylene lanolin, polyoxyethylene polyoxypropylene liquid lanolin, poly Oxyethylene stearyl stearate, polyoxyethylene phytosterol, polyoxyethylene decyl phenyl ether, polyethylene glycol monolaurate, polyethylene glycol dilaurate, polyethylene glycol palmitate Ester, polyethylene glycol dioctanoate, polyethylene glycol dipallate, polyethylene glycol monooleate, polyethylene glycol diacetate 150 ester, polyethylene glycol monostearate , polyethylene glycol stearate, polyoxyethylene glyceryl tristearate, glycerol fatty acid polyethylene glycol 300 ester, lanolin fatty acid polyethylene glycol 600 ester, lanolin fatty acid polyethylene glycol 1000 ester , polyglyceryl monooleate (36), polyoxyethylene sorbitan monolaurate (20E.O.), polyoxyethylene coconut oil fatty acid sorbitan (20E.O.), monopalmitate polyoxyethylene sorbitol Alkyd anhydride (20O.E.), oleic acid polyoxyethylene sorbitan (40E.O.), monooleic acid polyoxyethylene sorbitan (6E.O.), monooleic acid polyoxyethylene sorbitan ( 20E.O.), single Polyoxyethylene sorbitan laurate, tetraoleic acid polyoxyethylene sorbitan, trioleic acid polyoxyethylene sorbitan (20E.O.), monostearic acid polyoxyethylene sorbitan (6E.O. ), polystearic acid sorbitan monostearate (20E.O.), polyoxyethylene sorbitan tristearate (6E.O.), hexasuccinate polyoxyethylene sorbitan, isostearyl Acid polyoxyethylene sorbitan (3E.O.), polyoxyethylene glyceryl monostearate, polyoxyethylene sorbitan beeswax, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene (20) Oxypropylene (15) butyl ether, polyoxyethylene (35) polyoxypropylene (28) butyl ether, polyoxyethylene (36) polyoxypropylene (36) butyl ether, polyoxyethylene (37) polyoxypropylene (38) butyl ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxyethylene polyoxypropylene oligosuccinate (3E.O.) ( 20P.O.), polyoxyethylene polyoxypropylene hexane glycol ether (300E.O.) (75P.O.), tris(polyoxyethylene isostearic acid) trimethylolpropane (3E.O.) , polyoxyethylene oleic acid glyceride, polyoxyethylene (10) polyoxypropylene glycol (30), polyoxyethylene (16) polyoxypropylene glycol (30), polyoxygen Alkene (25) polyoxypropylene glycol (30), polyoxyethylene (160) polyoxypropylene glycol (30), polyoxyethylene (30) polyoxypropylene glycol (35), polyoxyethylene (200) polyoxypropylene glycol (40), polyoxyethylene (200) polyoxypropylene glycol (70), polyoxyethylene (20) polyoxypropylene glycol (15) butyl ether, polyoxyethylene (6) polyoxypropylene glycol (30), poly Oxyethylene (1) polyoxypropylene (4) cetyl ether, polyoxyethylene (1) polyoxypropylene (8) cetyl ether, polyoxyethylene (20) polyoxypropylene (4) hexadecane Ether, polyoxyethylene (20) polyoxypropylene (8) cetyl ether, polyoxypropylene (9) diglyceryl ether, polyoxypropylene stearyl ether, ethylene diamine tetrapolyoxyethylene polyoxypropylene , polyoxyethylene (6E.O.) mercapto / sorbitan, lauric acid polyoxyethylene glyceride, coconut oil fatty acid polyoxyethylene glyceride, polyoxyethylene diethanolamine laurate (4E.O.) , dioctyl dodecyl glutamate, lauric acid glutamic acid dipolyoxyethylene stearyl ether diester, lauryl glutamic acid polyoxyethylene octyl dodecyl ether diester, Polyoxyethylene glyceryl glutamate isostearate, polyoxyethylene glyceryl glutamate Hardened castor seed oil, sorbitan diethanolamine, undecylenic acid monoethanol decylamine, coconut oil fatty acid monoethanol decylamine, coconut oil fatty acid diethanol amide (type 1:2), coconut oil fatty acid diethanol Indamine, lauric acid decylamine, lauric acid diethanolamine, lauric acid isopropylamine, lauric acid myristic acid diethanolamine, lauric acid myristic acid triethanolamine, myristate diethanolamine, Palmitic acid ethanolamine, stearic acid monoethanolamine, stearic acid diethanolamine, stearic acid diethylaminoethylguanamine, isostearic acid diethanolamine, oleic acid diethanolamine , linoleic acid diethanolamine, tallow fatty acid monoethanolamine, tallow fatty acid diethanolamine, hardened tallow fatty acid diethanolamine, lanolin fatty acid diethanolamine, polyoxyethylene coconut oil fatty acid guanamine (5E. O.), polyoxyethylene (2) coconut oil fatty acid monoethanol decylamine, polyoxyethylene (5) coconut oil fatty acid monoethanol decylamine, polyoxyethylene (10) coconut oil fatty acid monoethanol decylamine, polyoxyethylene coconut Oil fatty acid diethanolamine, polyoxyethylene tallow alkyl Amine (2E.O.), polyoxyethylene coconut oil alkyl dimethylamine oxide, coconut oil alkyl dimethylamine oxide liquid, stearin dimethylamine oxide, oleyl dimethylamine Oxide, dihydroxyethyl laurylamine oxide liquid, rosin acid neopentyl alcohol, hexaglyceryl oleate, sesquistearic acid methyl glucoside, polyethylene glycol monooleate, polyethylene glycol Alkyl acid ester, polyoxyethylene alkyl ether, polyethylene glycol diether, lauryl diethanol decylamine, fatty acid isopropanolamine, maltitol hydroxy fatty acid ether, alkylated polysaccharide, alkyl glucoside, Trehalose monosaccharide ester such as monomyristate trehalose, monoisostearate trehalose, monoundecenoic acid trehalose, polyoxyethylene dioleic acid methyl glucoside (120E.O.), sucrose fat Sugar esters such as acid esters, coconut oil fatty acid glyceryl groups, lipophilic glyceryl monostearate, self-emulsified glyceryl monostearate, polyglyceryl monostearate, polyglyceryl alkyl esters, sorbitol Anhydride monooleate, polyethylene glycol monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sterol, poly Ethylene lanolin, polyoxyethyleneated beeswax, polyoxyethylene hardened castor seed oil, glycerin fatty acid ester, polyglycerin fatty acid ester, POE sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE glycerin Fatty acid esters, POE alkyl ethers, POE fatty acid esters, POE hardened castor seed oil, POE castor seed oil, POE. POP copolymer, POE. POP alkyl ether, polyether modified polydecyloxylaurate melamine, alkylamine oxide, hydrogenated soybean phospholipid, octyl glucoside, citric acid fatty acid glyceride, citric acid stearic acid glyceride, corn oil PEG-8 ester, cocoamine DEA, cocoamine MEA, cocoamine MIPA, sucrose stearate, hydrogenated palm kernel oil fatty acid glyceride, hydrogenated palm oil fatty acid PEG-200 glyceride, hydrogenated palm oil fatty acid glycerin Esters, sorbitan sesquisic acid, polyglyceryl sesquistearate, glycerol monosuccinate-2, sesquistea PEG-20 methyl glucose, etc. Nonionic surfactant, sodium stearate, zinc stearate, calcium stearate, magnesium stearate, aluminum stearate, aluminum isostearate, triethanolamine stearate, potassium palmitate, sixteen Sodium alkyl sulfate, sodium lauryl phosphate, sodium lauryl phosphate, triethanolamine palmitate, sodium polyoxyethylene lauryl phosphate, sodium N-mercapto glutamate, sodium palmitate, sodium laurate, potassium laurate, Zinc laurate, triethanolamine laurate, sodium lauryl sulfate, sodium lauryl sulfate, lauryl Potassium acid, ammonium lauryl sulfate, monoethanolamine lauryl sulfate, diethanolamine lauryl sulfate, triethanolamine lauryl sulfate, sodium lauryl diaminoethylglycinate, triethanolamine alkyl sulfate, sulfonated castor oil, Linear dodecyl benzene sulphate, polyoxyethylene hardened ricin seed oil maleic acid, mercaptomethyl taurine, fatty acid soap, α-mercapto sulfonate, alkyl sulfonate, alkyl allyl Sulfonate, alkylnaphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate, alkyl decyl sulfate, alkyl phosphate, POE alkyl phosphate, alkyl guanamine phosphate, aryl hydrazine Alkyl taurate, N-decylamino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, sodium alkyl sulfonate, mercapto isethionate, hydrazinolysis Collagen peptide salt, perfluoroalkyl phosphate, soap raw material, potassium soap, zinc undecylenate, potassium soap raw material, coconut oil fatty acid potassium, sulfated castor seed oil, sodium myristate, meat Potassium citrate, zinc myristate, magnesium myristate, sodium oleate, potassium oleate, N-mercapto-L-glutamic acid triethanolamine, N-mercapto-L-glutamine Sodium, N-coconut oil fatty acid thiol-L-glutamate, N-coconut oil fatty acid. Hardened tallow fatty acid sulfhydryl-L-glutamate, N-coconut fatty acid thiol-L-glutamic acid triethanolamine, stearyl-L-glutamic acid disodium, N-hardened tallow fatty acid thiol- L-glutamate, N-lauryl-L-glutamate, N-stearyl-L-glutamic acid, N-lauryl-L-lysine, Laurel-L - glutamic acid triethanolamine, L-arginine ethyl. DL-pyrrolidone carboxylate, N-coconut oil fatty acid thiol-L-arginine ethyl. DL-pyrrolidone carboxylate, coconut oil fatty acid sarcosine, coconut oil fatty acid sodium sarcosinate, coconut oil fatty acid cresine triethanolamine, lauryl sarcosine, sodium lauryl sarcosinate, bay laurel Tribasic creatinine triethanolamine, carboxylated polyoxyethylene tridecyl ether sodium salt (3E.O.), β-lauryl alaninate, sodium lauryl propionate, coconut fatty acid methyl tauro Potassium acid, coconut oil fatty acid methyl taurate, sodium lauryl methyl taurate, sodium lauryl sulfonate, coconut oil fatty acid methyl propylamine solution, coconut oil fatty acid triethanolamine solution, laurel base Sodium-β-alanine sodium solution, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolium disodium taudecyl sarcosine, coconut oil alkyl-N-carboxyethyl-N - Hydroxyimidazolium betaine sodium, coconut oil alkyl-N-carboxyethoxyethyl-N-carboxyethylimidazolium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N -carboxymethylimidazolium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxymethylimidazolium disodium lauryl sulfate, nutmeg -β-alanine sodium solution, sodium stearyl methyl taurate, sodium tetradecene sulfonate, sodium dodecylbenzene sulfonate, triethanolamine dodecylbenzenesulfonate, sodium alkane sulfonate, alkyl Ammonium sulfate, sodium octylphenoxydiethoxyethyl sulfonate, coconut oil alkyl magnesium sulfate. Triethanolamine, sodium myristyl sulfate, sodium hexadecane sulfate, sodium oleate, triethanolamine oleate, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate (2E.O. ), polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene alkyl ether ammonium sulfate (3E.O.) solution, polyoxyethylene alkyl ether sulfate diethanolamine (3E.O.) solution, polyoxyethylene alkyl Triethanolamine ether sulfate (3E.O.) solution, sodium polyoxyethylene alkyl ether sulfate (3E.O.) solution, hardened coconut oil fatty acid sodium glyceryl sulfate, polyoxyethylene (5) coconut oil fatty acid monoethanol decylamine Phosphate ester, polyoxyethylene alkyl (12-14) ether phosphate (2E.O.), (8E.O.), (10E.O), polyoxyethylene lauryl ether phosphate, polyoxyethylene lauryl ether phosphate Sodium, polyoxyethylene cetyl ether phosphate, polyoxyethylene cetyl ether sodium phosphate, polyoxyethylene stearyl ether, polyoxyethylene cholesteryl ether, polyoxyethylene stearyl ether phosphate, polyoxyethylene Oleyl ether phosphate, polyoxyethylene oleyl ether sodium phosphate, polyoxyethylene oleyl ether diethanolamine, polyoxyethylene alkyl phenyl ether phosphate, polyoxyethylene alkyl phenyl ether Triethanolamine, polyoxyethylene polyoxypropylene cetyl ether phosphate, polyoxypropylene glyceryl ether phosphate, polyoxypropylene butyl ether phosphate, polyoxyethylene sulfosuccinate disodium lauryl, coconut oil fatty acid ethyl ester sulfonate Sodium, sodium dioctyl sulfosuccinate, sodium octylphenoxydiethoxyethyl sulfonate, disodium lauryl sulfosuccinate, disodium oleate sulfosuccinate, polyoxyethylene alkyl ( C12-15) ether phosphate, polyoxyethylene alkyl (C12-14) disodium sulfosuccinate (7E.O.), sulfosuccinate polyoxyethylene lauryl thioglycolate disodium (5E.O.), Isostearyl sulphate sodium lactate, undecylenyl hydrazino hydrolyzed collagen sodium, undecenyl hydrazino hydrolyzed collagen potassium, undecyl hydroxyethyl imidazolium betaine sodium, lauric acid hydrolyzed collagen sodium, coconut oil Fatty acid hydrolyzed collagen sodium, coconut oil fatty acid hydrolyzed collagen potassium, coconut oil fatty acid hydrolyzed collagen potassium solution, coconut oil fatty acid hydrolyzed collagen triethanolamine, isostearyl sulfhydryl hydrolyzed collagen, isostearyl sulfhydryl hydrolyzed silk, different Stearic acid hydrolyzed collagen aminomethylpropanediol salt, B Diamine -N, N, N ', N ' - tetrakis (2-hydroxypropyl) bis oleate, dodecyl acyl muscle leucine, sodium lauryl dipropyl amine solution (30%), oil acyl Creatine, myristyl-β-alanine sodium, undecylhydroxyethylimidazolium betaine, alkyl (C12,13,16) ammonium sulfate, alkyl (C11,13,15) sulfate Triethanolamine (1), alkyl (C11, 13, 15) triethanolamine sulfate (2), alkyl (C12-15) triethanolamine sulfate, alkyl (C12-14) triethanolamine sulfate, alkyl (12, 13 Sodium sulfate, polyoxyethylene alkyl ether triethanolamine (3E.O.) solution, (C11-15) alkane polyether-3 sodium sulfate, (C12,13) alkane polyether-3 sodium sulfate , (C12-15) sodium alkane polyether-3, (C12, 13) alkanol polyether-3 TEA, (C12, 13) alkanol polyether-3 sulfuric acid (TEA/Na), PEG-3 coconut fatty acid guanamine MEA sulfuric acid Na, PEG-5 coconut fatty acid guanamine MEA phosphoric acid, PEG-5 lauryl citrate sulfosuccinate 2 sodium, PEG-5 cetyl-10 phosphate, PEG-25 butyl Phosphoric acid, sodium alkyl (C14-18) sulfonate, alkyl (C20-22) phosphoric acid, isolauryl polyether-4 phosphoric acid, undecylenylglycine, potassium fatty acid potassium, oleyl myoamine , oleyl methyl taurate, oleyl-3 phosphate, oleyl-4 phosphate, oleyl-5 phosphate, oleyl-10 phosphate, oleyl-20 phosphate, Oleoalcohol-7-sodium phosphate, oleyl-8-phosphate, sodium olefin (C14-16) sulfonate, octylglycine, sodium cocoyl amide, triethanolamine cocoyl propylamine , sodium cocoyl isethionate, ammonium cocoyl isethionate, potassium cocoyl glycinate, sodium cocoyl glycinate, cocoyl glutamic acid triethanolamine, Coconut oil glutamic acid, cocoyl glutamic acid 2 sodium, cocoyl glutamate, etc., coconut oil glutamic acid glutamate, cocoyl creatinine, cocoyl ketone Sodium Creatine, Cocoyl Creatine Triethanolamine, Cocoyl Sodium Taurate, Cocoyl Methyl Alanine, Cocoyl Methylalanine, Cocoyl Methyl Cow Sulfonic acid, potassium cocoyl methyl taurine, magnesium cocoyl methyl taurate, sodium cocoyl methyl taurate, sodium cocoyl succinate, cocool Sodium ether sulfate, di(C11-15)alkanol-2phosphate, di(C12-15)alkanol Ether-4 phosphoric acid, di(C12-15)alkanol polyphosphate-8 phosphoric acid, di(C12-15)alkanol polyether-10 phosphoric acid, dioleylphosphoric acid, dioleyl-8-phosphate, Dioleyl oleate-8 sodium phosphate, dicocoyl ethylene diamine PEG-15 sodium sulfate, dilauryl polyether-10 sodium phosphate, stearyl polyether-2 phosphoric acid, stearyl polyether-3 Phosphoric acid, calcium stearyl lactic acid, sodium stearyl sulphate, sodium decyl decyl sulfonamide MEA-2, sodium sulfosuccinate, sodium melacate, sodium lauryl succinate, sodium succinate Cetylphosphonate DEA, potassium cetyl phosphate, sodium cetyl sulfate, cetyl-10 phosphate, cetyl-20 phosphate, tris-cetyl stearyl-4 phosphate, tridecane Alcohol-4carboxylic acid, tridecyl polyether-8 carboxylic acid, tridecyl polyether-4 carboxylate, tridecyl alcohol polyether-7 carboxylate, tridecyl alcohol polyether 3 sodium acetate, tridecyl polyether-7-7 potassium phosphate, trilauryl polyether-4 phosphoric acid, lactic acid oil base, palm fatty acid sodium glutamate, palmitoyl glutamate, palmitoyl-sodium sarcosinate , palmitoyl valine, sodium palmitosyl amide, sodium palmitoyl methyl tauroate Myristyl potassium glutamate, myristyl sodium glutamate, myristyl sodium myristate, myristyl methyl taurate, coconut fatty acid potassium, coconut fatty acid triethanolamine, coconut fatty acid concentrate Amino acid, sodium lauryl diacetate, sodium lauryl glycolate, laureth-5 carboxylic acid, laureth-6 carboxylic acid, laureth-11 carboxylic acid, laureth-5 Sodium carboxylate, sodium laureth-6 carboxylate, sodium laureth-11 carboxylate, laureth-5 acetic acid, laureth-6 acetic acid, laureth-4,5 potassium acetate , laureth-3 sodium acetate, laureth-4 sodium acetate, laureth-5 sodium acetate, laureth-6 sodium acetate, laureth-11 sodium acetate, lauryl polyether MIPA, sodium laureth sulfate, lauryl alcohol triethanolamine, laureth-2 ammonium sulfate, laureth-3 ammonium sulfate, laureth-1 phosphate, laureth-2 Phosphoric acid, laureth-4 phosphate, sodium lauryl aspartate, sodium lauryl glutamate, sodium lauryl lactate, lauryl methyl propyl Anionic surfactants such as potassium amide, lauryl methyl methionine triethanolamine, di-hexadecyl phosphate, cetyl phosphate, etc., lauryl trimethyl ammonium chloride, dicocoyl chloride Dimethylammonium chloride, myristyldimethylbenzylammonium chloride, cetyltrimethylammonium chloride, laurylpyridinium chloride, cetylpyridinium chloride, benzyl chloride Ethoxyammonium, stearin trimethylammonium chloride, benzalkonium chloride chloride, benzalkonium chloride chloride solution, laurylamine oxide, alkyltrimethylammonium chloride, Stearic acid strontium trimethylammonium chloride, chlorinated stearyl dimethyl benzyl ammonium chloride, dimethyl stearyl ammonium chloride treated hectorite, benzyl chloride dimethyl stearate ammonium treated water Pyroxene, distearium dimethylammonium chloride, distequine dimethylammonium chloride treated bentonite, dialkyldimethylammonium chloride, tris(polyoxyethylene) stearyl ammonium chloride ( 5E.O.), bis(polyoxyethylene) oleylmethylammonium chloride (2E.O.), stearyloxyethylaminomethylmercaptomethylpyridinium chloride, chlorinated polyoxypropylene Diethylammonium chloride, alkyldiamine ethylglycine hydrochloride Liquid, alkylisoquinoline hydrazine bromine, lauryl trimethylammonium bromide, cetyltrimethylammonium bromide, stearyl trimethylammonium bromide, cetyl trimethyl Ammonium saccharin, stearin trimethylammonium saccharin, polyethylene glycol. Epichlorohydrin. Coconut oil alkylamine. Dipropylene triamine condensate, polyethylene glycol. Epichlorohydrin. Tallow alkylamine dipropylene triamine condensate, ethyl lanolin fatty acid aminopropyl ethyl dimethyl ammonium (1), (2), benzalkonium bromide trimethylammonium chloride Aminopropyldimethylhydroxypropylammonium, diethylaminoethylguanamine stearate, dimethylaminopropyl decylamine stearate, lanolin derivative quaternary ammonium salt, PEG-5 Oil amine, PEG-2 oil ammonium chloride, PEG-2 cocamine, PEG-3 cocamine, PEG-5 cocamine, PEG-10 cocoamine, PEG-15 cocoamine, PEG-2 White mango seed oil, mercaptoethyl methyl methyl ammonium sulfate, alkyl (C12, 14) oxy hydroxypropyl spermine hydrochloride, alkyl (C16, 18) trimethyl ammonium chloride, different Alkyl (C10-40) guanamine propyl ethyl dimethyl sulphate ammonium, isostearyl hydrazine ethyl imidazolium ethyl sulphate, thorn tree hydroxypropyl trimethyl ammonium chloride, quaternary ammonium Salt-33, quaternary ammonium salt-91, coconut amidoxime PG dimethylammonium oxalic acid, coconut amphetamine propyl betaine guanamine MEA chloride, cocoyl arginine ethyl PCA, coconut Trimethylammonium methylsulfate, fenugreek hydroxypropyltrimonium chloride, acetic acid (myristamide/palm) Butyl hydrazine, dialkyl (C12-18) dimethyl ammonium chloride, dicocoyl ethyl hydroxyethyl methyl ammonium methyl sulfate, dicocodimethyl dimethyl ammonium chloride, diste samarium Dimethylammonium chloride, distearyl ethyl hydroxyethyl methyl ammonium methyl sulfate, di-hexadecyl dimethyl ammonium chloride, dipalmityl ethyl hydroxyethyl methyl sulfate Ammonium ester, dihydroxypropyl PEG-5 linoleic acid ammonium chloride, dimethyl PABA decyl propyl lauryl dimethyl ammonium p-toluene sulfonic acid, dimethyl stearylamine, stearyl amide ethyl Ethylamine, stearylamine dimethylamine, stearyl ammonium chloride, stearin trimethyl ammonium saccharin, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, hard Lipoxypropyltrimethylammonium chloride, cisplatin, cetylpyridinium chloride, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, sixteen Alkyltrimethylammonium methylsulfate, soybean trimethylammonium chloride, palmitosylpropyltrimethylammonium chloride, panthenolylhydroxypropylstearyldimethylammonium chloride, hydroxyethyl ten Hexamethyldimethylammonium phosphate, hydroxypropyltrimethyl Honey, hydroxypropyl bishydroxyethyl dimethyl ammonium chloride, behenamide dimethyl dimethylamine, behenamide dimethyl dimethylamine, behenyl trimethyl ammonium chloride, hawthorn Trimethylammonium methyl sulfate, poloxamine 701, poloxamine 702, poloxamine 704, bishydroxyethyl cetyl decyl malonate, coconut oil alkyl PG dimethyl chloride Cationic surfactants such as ammonium sulphate, lauryl trimethyl ammonium chloride, lauryl pyridinium chloride, linseed guanamine PG dimethyl dimethyl ammonium phosphate, etc., lauryl dimethyl amino acetic acid Betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, undecyl-N-hydroxyethyl-N-carboxymethylimidazolium betaine, coconut oil alkylbetaine , coconut oil fatty acid guanamine propyl betaine, stearin dihydroxyethyl betaine, stearin dimethylaminoacetate betaine, bis(stearin-N-hydroxyethyl imidazoline) chloroacetic acid Body, coconut oil fatty acid hydrolyzed collagen, oil hydrolyzed collagen, hydrolyzed collagen cetyl, lauric acid guanamine propyl betaine, myristyl hydrolyzed gum Protein solution, alkylaminoethylglycine hydrochloride solution, carboxybetaine type, guanamine betaine type, sulfobetaine type, hydroxysulfobetaine type, decyl sulfonate group, etc. Betaine type, diphosphorus betaine type, aminocarboxylate type, imidazoline derivative type, guanamine type, PEG-3 laurylamine oxide, oleylamine oxide, oleyl betaine, (癸Mercapto/nonylamine propyl betaine, cocoalkylamine oxide, sodium cocoamphoacetate, sodium cocoamphodiacetate, sodium cocoa amphoteric diacetate, cocoon Sodium amphoteric propionate, dihydroxyethyl laurylamine oxide, stearylamine oxide, stearin betaine, palm nucleus fatty acid guanamine ethyl hydroxyethylaminopropionate, palm nucleus fatty acid guanamine propyl Betaine, hydroxyalkyl (C12,14) hydroxyethylalanine, heptadecylhydroxyethylcarboxylate methylimidazolium chloride/heptadecylbishydroxyethylimidazolium, myristylamine Betaine, myristylamine oxide, myristyl betaine, laurylamine propylamine oxide, lauryl propyl hydroxy sulfonate Betaine, lauryl propyl betaine, sodium lauryl propionate, laurylamine oxide, sodium lauryl dipropionate, lauryl hydroxy sulfobetaine, lauryl betaine, laurel Amphoteric surfactants such as sodium acetate, lauric acid and lysine, saponin, sodium saponin, saponin, hydrogenated lecithin, hydrogenated lysolecithin, hydrogenated lecithin, cephalin, phospholipid Amine acid, lysolecithin, phospholipid, lecithin, water-soluble collagen, and the like. Among these surfactants, nonionic surfactants are preferred, such as polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerol fatty acids. A nonionic surfactant such as an ester, a polyoxyethylene glycerin fatty acid ester, a polyoxyethylene hardened castor seed oil, or a polyoxyethylene sorbitan fatty acid ester is more preferable.

In particular, in the case where a lotion containing one or more kinds of skin external compositions composed of L-ascorbic acid, a derivative thereof, and the like is blended, the use of a cosmetic-suppressing method is used. The effect of time turbidity and precipitation is high, and it is preferred that the following surfactants are generally used in the field of cosmetics. That is, the following one kind or a combination of two or more kinds of L-arginine ethyl groups may be used alone. DL-pyrrolidone carboxylate, polyoxyethylene glyceryl glutamate isostearate, PEG-9 polydimethyl methoxyethyl dimethyl oxane, coconut oil fatty acid sorbitol, poly Oxyethylene polyoxypropylene decyltetradecyl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene methyl glucoside, polyoxyethylene lauryl ether, polyoxyethylene hardened ramie Seed oil, polyoxyethylene hydrogenated castor seed oil, isostearic acid sorbitan, isostearic acid polyoxyethylene hardened castor seed oil, glycerin fatty acid ester, diisostearic acid polyglyceryl, sucrose fatty acid Ester, sodium stearyl glutamate, sodium stearyl sulphate, sorbitan sesquistearate, sorbitan sorbitan, polyoxyethylene alkyl (C12-15) ether phosphate, polyoxygen Ethylene cholesterol Ether, polyoxyethylene cetyl ether phosphate, polyoxyethylene hexadecane ether, polyoxyethylene phytosterol, polyoxyethylene behenyl ether, monooleic acid polyoxyethylene sorbitan (20E.O ), glyceryl monostearate, polyethylene glycol monostearate, polyoxyethylene glyceryl monostearate, polyoxyethylene sorbitan monolaurate, dioctyl 12 base of lauric acid glutamic acid Preferably, the ester, the hydrolyzed collagen solution, the glyceryl monostearate, the hydrogenated soy lysophospholipid, the hydrogenated soybean phospholipid, and the surfactant selected from the water-soluble collagen are preferred.

In addition, in the lotion, in order to improve the quality and stability, one or two kinds selected from the following spices, pigments, preservatives, bactericides, ultraviolet absorbers, metal blocking agents, and buffers may be blended. Each of these is usually 0.0001% by mass or more, preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass, still more preferably 0.1 to 10% by mass per mass of the lotion of the present invention. Blending.

(spices)

In terms of perfume, benzoic aldehyde, cinnamaldehyde, cyclamate, citral, citronellal, 2-methyl-3-(4-methylphenyl)-propanal, undecenal, methyl Mercaptoacetaldehyde, 3,7-dimethyl-1-octanal, hydroxycitronellal, methoxy citronellal, perillaldehyde, myrtenal, syring aldol, n-green leaf aldehyde, 2- Methyl butyraldehyde, isovaleraldehyde, n-pentanal, acetaldehyde, n-heptanal, n-octanal, n-furfural, 2-methyl octanal, 3,5,5-trimethylhexanal , 1-furfural, undecalkanal, dodecane aldehyde, 2-methylfurfural, 2-methylundecal aldehyde, tridecalkanal, tetradecane aldehyde, 2-pentyl Alkenal, cis-3-hexenal, trans-2-hexenal, trans-2-heptenal, 4-heptenal, trans-2- Octenal, trans-2-nonenal, cis-6-nonenal, 2,6-dimethyl-5-heptenal, trans-4-nonenal, cis-4- Nonenal, trans-2-nonenal, 2,5,6-trimethyl-4-heptenal, 10-undecenal, trans-2-undecenal, trans -2-dodecenal, 3-dodecenal, trans-2-trienol, 2,6,10-trimethyl-9-undecene-1-al 2,4-hexadienal 2,4-heptadienal, 2,4-octadienal, 2,4-nonadienal, 2,6-nonadienal, 2,4-anthracene Dienal, 2,4-undecadienal, 2,4-dodecadienal, 5,9-dimethyl-4,8-nonadienal, 3,7,9-three Methyl-2,6-decadien-1-al, 2,6,10-trimethyl-5,9-undecadienal, α-methylene citronellal, camphoral aldehyde, ring Citral, isocyclic citral, 2,6,6-trimethyl-1,3-cyclohexadien-1-carboxyaldehyde, 6,10-dimethyl-3-hexa-9-undecene Aldehyde, geranyloxyacetaldehyde, dimethyltetrahydrobenzoin, 3-propylbicyclo[2,2,1]-5-hepten-2-carboxyaldehyde, methoxydicyclopentadienylcarboxylate Aldehyde, 4-tricycloarrylbutyraldehyde, 4-(4-methyl-3-cyclohexenylene-1)pentanal, 4(3)-(4-methyl-3-pentyl -1-yl)-3-cyclohexene-1-carboxyaldehyde, violet aldehyde, enolaldehyde, 4-cyclooctene-1-carboxaldehyde, p-tolyl aldehyde, phenylacetaldehyde, 3-benzene Butyraldehyde, anisaldehyde, p-methylphenylacetaldehyde, p-isopropylphenylacetaldehyde, hydrogenated atolaldehyde, p-methyl hydrogenated atolaldehyde, p-isopropyl hydrogenated atolaldehyde, Phenylpropanal, β-methylhydrocinnamaldehyde, jasmonaldehyde, pozheng red aldehyde, sea breeze aldehyde, selapiraldehyde, salicylaldehyde, sharp anisaldehyde, o-methoxybenzoin, o-a Oxycinnamaldehyde, octanal aldehyde, vanillin, ethyl vanillin, methyl vanillin (3,4-dimethoxybenzoin), neo-jasmine aldehyde, phenoxyacetaldehyde, p-methylbenzene Oxyacetaldehyde, furaldehyde, 5-methylfurancarboxaldehyde, 5-hydroxymethyl-2-furancarboxaldehyde, furan Acrolein, neolinglantaldehyde, fresh oxalic acid, high citrus aldehyde, juniper essential oil, vertol aldehyde, lilac aldehyde, mefyral aldehyde, Aegron tar, Cocarl, α-methyl cinnamaldehyde, Aldehydes such as α-butylcinnamaldehyde, α-pentylcinnamaldehyde, α-hexylcinnamaldehyde, aldehyde ethyltetramethyltetrahydronaphthalene, rosin acetate, garyl acetate, benzyl acetate, Acetyl acetate, isoamyl salicylate, benzyl salicylate, hexyl salicylate, cis-3-hexenyl salicylate, ethyl formate, cis-3- Hexenyl ester, benzoic acid ester, citronellyl formate, geranyl formate, benzyl formate, phenethyl formate, ethyl acetate, butyl acetate, isoamyl acetate, ring Methyl amyl acetate, hexyl acetate, cis-3-hexenyl acetate, trans-2-hexenyl acetate, isodecyl acetate, citronellyl acetate, lavender acetate, acetic acid Geranyl ester, lauryl acetate, terpene acetate, menthol acetate, menthyl acetate, norbyl acetate, n-borneol acetate, isobornyl acetate, pt-butyl acetate Cyclohexyl ester, ot-butylcyclohexyl acetate, tricyclodecenyl acetate, 2,4-dimethyl-3-cyclohexene-1-methyl acetate, phenylethyl acetate, phenylacetate Ester, dimethylbenzyl acetate, cinnamyl acetate, fenyl acetate, p-cresol acetate, piperonyl acetate, eugenol, eugenol, acetal acetate, cedar acetate , ethyl propionate, isoamyl propionate, citronellyl propionate, geranyl propionate, benzoic acid propionate, terpene propionate, benzyl propionate, cinnamon propionate Ester, allyl cyclohexylpropionate, tricyclodecenyl propionate, ethyl butyrate, ethyl 2-methylbutyrate, butyl butyrate, isoamyl butyrate, hexyl tyrosinate, agaric acid Base ester, geranyl butyrate, citronellyl butyrate, benzyl butyrate, isobutylate 3-hexenyl ester, citronellyl isobutylate, geranyl isofate, isobutylate, isobutyl tyrosinate, phenethyl isobutylate, tricyclodecenyl isobutylate , ethyl ketoacetate, propyl oxalate, citronellyl glucosinolate, geranyl isoflavone, benzyl isopropyl oxalate, cinnamyl isopropyl oxalate, phenethyl acetoacetate Ester, ethyl linoleate, allyl sorbate, ethyl heptate, allyl heptate, ethyl sorbate, citronellyl chrysanthemum, methyl benzoate , benzoic acid ethyl ester, isobutyl benzoate, isoamyl benzoate, benzoic acid geranyl ester, benzoic acid benzoic acid ester, benzoic acid benzyl ester, benzoic acid phenethyl ester, phenyl Methyl acetate, ethyl phenylacetate, isobutyl phenyl acetate, isoamyl phenyl acetate, geranyl ester of phenylacetate, benzyl phenylacetate, phenylethyl phenylacetate Ester, p-toluene phenylacetate, methyl cinnamate, ethyl cinnamate, benzyl cinnamate, cinnamyl cinnamate, phenyl cinnamate Ester, methyl salicylate, ethyl salicylate, isobutyl salicylate, amyl salicylate, hexyl salicylate, cis-3-hexenyl salicylate, Phenylethyl salicylate, methyl jasmonate, methyl dihydrojasmonate, FRUTATE, allyl 2-pentyloxyglycolate, 3-methyl-3-phenyl ring Ethyl oxypropionate, ethyl 2-valerate, 4-ethenyloxy-3-pentyltetrahydropyran, cyclohexyl salicylate, ethyl 2-cyclohexylpropionate, ethyl Esters of tricyclo[5.2.1.02,6]nonane-2-carboxylate, 2-methylpentyl 2-methylvalerate, γ-undecalactone, pentadectone (cyclo-decene) Pentaerythritol lactone, cyclopentadecanolide (oxetane-1-one), oleyl lactone, cyclohexadecanolide, 10-oxahexadecanolide, 11-oxo Hexadecyl lactone, 12-oxahexadecanolide, ethylene dodecane II Acid ester, γ-butyrolactone, γ-valerolactone, angelica lactone, γ-caprolactone, γ-heptanolactone, γ-caprolactone, γ-decalactone, 3-methyl-4- Octolactone, γ-decalactone, γ-dodecanolactone, γ-synthetic jasmonide, natural jasmonide, cis jasmine lactone, lactone jasmonone, synthetic jasper lactone, mentholactone, n -butyl azlactone, propylene azlactone, butylene azlactone, δ-caprolactone, δ-octanolactone, Trivalon, δ-decalactone, δ-decalactone, δ-2- Terpene lactone, δ-undecalactone, δ-dodecanolactone, δ-tridecanolide, δ-tetradecanolactone, Lactoscatone (decahydro-4,α-hydroxy-2,8,8- Trimethylnaphthalene-2-carboxylic acid-δ-lactone), coumarin, dihydrocoumarin, cyclohexyl lactone, 6-methylcoumarin, ε-decalactone, ε-twelve Lactones such as esters, acetaminophen, carbon, prolone, piperonone, piperone, camphor, isophorenone, norcodone, 2-heptanone, 2-pentanone, 3-hexyl Ketone, 3-heptanone, 4-heptanone, 2-octanone, 3-octanone, 2-nonanone, 3-fluorenone, 2-undecone, 2-tridecanone, methyl isopropyl ketone , ethyl isoamyl ketone, trimethyl carbonyl oxide, Butylene acetonide, methylheptadienone, methylheptenone, dimethyl octenone, 4-methylene-3,5,6,6-tetramethyl-2-heptanone, geranyl Acetone, farnesylacetone, ethyl hydrazine ethanol, 5-hydroxy-4-octanone, methyl lavone, diethyl hydrazine, 2,3-pentanedione, 2,3-hexanedione, 3,4-hexyl Diketone, 2,3-heptanedione, etidinylpentyl, pentylcyclopentanone, pentylcyclopentenone, 2-cyclopentylcyclopentanone, hexylcyclopentanone, 2-n-g Cyclopentanone, cis-jasmone, dihydrojasmone, iso-jasmone, trimethylpentylcyclopentanone, sedum (2-butylene-3,5,5(3,3,5)- Trimethylcyclopentanone), dexamethasone, methylcyclopentenolone, 3,5-dimethyl-1,2-cyclopentanedione, methylmethylcyclopentenedione, 2-tert -butylcyclohexanone, p-tert-butylcyclohexanone, 3,3-dimethylcyclohexyl Methyl ketone, 2-sec-butylcyclohexanone, atreketone, pond ketone, cryptone, p-tert-pentylcyclohexanone, methylcyclosterone, montenone, 4-cyclohexyl -4-methyl-2-pentanone, 2-(1-cyclohexen-1-yl)-cyclohexanone, maltol, ethyl maltol, oxide ketone, ethyl fenugreek lactone, 2-ethyl-4-hydroxy-5-methyl-3[2H]furanone, fenugreek lactone, furanol, acetamidine dimethylfuran, furfural acetone, 2-ethylindole-5-methylfuran 2-Ethylfuran, methyltetrahydrofuranone, benzhydryl ketone, benzophenone, methylnaphthyl ketone, 4-dihydro damitol, 4-methyl-4-phenyl-2-pentyl Ketone), α-methyl arylene acetone, piperonyl acetone, anise methylene acetone, anisidine acetone, p-methoxyphenylacetone, raspberry ketone, 3-methyl-4-benzene 3-buten-2-one, benzylideneacetone, p-methoxyacetophenone, p-methylacetophenone, propiophenone, acetophenone, isomaleone, alpha-damasolone , thiophenone, ionone, pseudoionone, methyl ionone, methyl ketone, 2,4-di-tert-butylcyclohexanone, allyl ionone, 2,6,6- Trimethyl- 2-cyclohexene-1,4-dione, 2-ethylindole-3,3-dimethylnorbornane, fulax, kecaone, cedarone, thixos, verbena , fennel ketone, watermelon ketone, Trimofix O, piracetone, yotericone, ketamine, 3-methylcyclopentadecanone-1, cycloheptadecan-9-en-1-one, cyclopentadecanone, ring Hexadecenophenone, 6-acetylhexamethylindan, 4-ethin-6-tert-butyl-1,1-dimethylindan, Trasmectone, toluene muskone, acetamidine Dimethyltetrahydrobenzoin, dihydrocarbon, dioxol, zingerone, ketones such as Iso E Super, phenylacetic acid, dartarol, linalool, musk ketone, methyl ionone, iris Oil, iris, guanidine, ylang-ylang oil, artemisia, oak, red myrrh resin, syringol, neroli, caramel, carvacrol, L-carbon, Camphor, ketone, carrot oil, clove oil, geraniol, geranyl nitro, sandalwood oil, cyclopentadecanolide, dihydrogeranol, jasmine stock, cinnamon bark oil, 1, 8-nonyl oleyl alcohol, sulphuric acid resin, red eucalyptus oil, cedarene, cedarol, caraway oil, thyme thyme oil, ketone, thioxenone, thymol, tuberose, azlactone, anthraquinone Alcohol, γ-萜, tilramaldehyde, 2,6-nonadienal, azlactone, baiqiuol, Baiqiuli oil, phenethyl alcohol, liming oil, cis-3 -hexenol, Peru balsam, citronella oil, liminyl alcohol, peppermint oil, pepper oil, geranyl aldehyde, citrus oil, borneol, pine algae resin, menthol, L-menthol, L-menthol Ketone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, lemon oil, rose stock, rose oxide, rose oil, rosemary oil, eucalyptus resin, lovage oil, star Sharp-toothed fennel oil, fir oil, musk oil, sunflower oil, ambergris tincture, ylang ylang liquid, iris resin, iris liquid, dwarf winter oil, Fragrance oleoresin, Elem resin base, Elmite tincture, oak moss concrete, oak mulch, oak moss resin, oak moss resin, oyster wood oil, osmanthus sinensis, osmanthus glutinous rice, red myrrh Tree resin, red myrrh tree stock, red myrrh tree oil, frankincense resin, frankincense stock, frankincense oil, caraway oil, oregano oil, oregano resin, orange flower liquid, orange flower concrete, perfume tree Oil, dipterophyllin aromatic resin, dipterophyllin aromatic resin oil, calyx bark oil, beaver incense liquid, acacia liquid, acacia oil, sassafras oil, sassafras liquid, carnation liquid, Brazilian sandalwood Oil, chamomile oil, cardamom oil, alum oil, alum resin, alum resin, caraway seed oil, iron pear oil, iron pear resin, iron pear wood concrete, eucalyptus oil, Bi Lan oil, 孜Oil, cumin, Acrylic oleoresin, sage oil, grapefruit oil, mane oil, cob gum resin, cob gum resin, cob gum resin, eucalyptus oil, sassafras oil, Yingshan original liquid, perilla oil, citronella oil, jasmine concrete, juniper oil, civet fragrant liquid, civet citron, clove narcissus liquid, agarwood oil, ginger oil, cinnamon oil, cinnamon leaf oil, Chinese fir oil, Suhe sesame oil, Spearmint oil, peppermint oil, sage oil, red eucalyptus oil, red eucalyptus oil, target oil, artemisia oil, dill oil, tea tree oil, tree moss, toluene aromatic resin, nutmeg oil, trumpet narcissus liquid , neroli oil, camphor stock, long white pine oil, basil oil, parsley leaf oil, caraway oil, caraway oil, peppermint oil, vanilla liquid, honeysuckle stock solution, geranium oil, valerian oil, Bitter orange oil, Xishouhua oil, Luohan tar, hyacinth stock, fennel oil, edible cactus stock, yam oil, lip oil, peppermint oil, benzoin tincture, benzoin resin, rosewood oil, camphor Oil, grass oil, grass coagulation , Prairie liquid, big oregano oil, citrus oil, orange oil, mimosa concrete, shy grassland liquid, mimosa oil, pine algae liquid, pine algae oil, musk liquid, musk tincture, grapefruit oil, artemisia oil , Laodan gum oil, labdan gum resin, lavender grassland liquid, lavender oil, lavender grassland liquid, galaxal oil, lemon citronella oil, rose concrete, irrigation oil, bay oil, bay leaf oil, bitter oil, Musk, civet, ambergris, beaver, musk, α-monoolefin, β-monoolefin, decene, geranyl, terpineol, terpinol, radix, γ- Hydrocarbons, tines of triene olefin, α-anisole, p-isopropyltoluene, β-syringene, β-farnesene, 1,3,5-undecenetriene, diphenylmethane, etc. Anisole, cinnamyl alcohol, phenylpropyl alcohol, dimethylbenzyl alcohol, phenylethyl methyl ethyl orthoester, 3-methyl-5-benzene Pentanol, resorcinol monomethyl ether, iso-eugenol, sandalwood, isobornyl cyclohexanol, Sandalore 210, Bagdanol, Sandalmysore core, Bramanol, Evanol , Polysantol (Polysantol), 2-ethoxy-4-methoxymethylphenol, trans-2-hexenol, cis-3-hexenol, 3-octanol, 1-octene 3-ol, 2,6-dimethyl-2-heptanol, 9-decenol, 4-methyl-3-nonene-5-ol, 10-undecenol, trans-2- Cis-6-nonadienal, nerol, citronellol, erythritol, geraniol, lavender, tetrahydrogeranol, tetrahydrolinol, hydroxycitronellol, 2,6 - dimethyl-3,5-octylene-2-ol, tert-1,4-nonan-4-ol, iso-menthol, nopol, farnesol, nerolidol, sweet myrrh , baiqierol, 2,4-dimethyl-3-cyclohexene-1-methanol, 4-isopropylcyclohexanol, 4-isopropylcyclohexane methanol 1-(4-isopropyl ring Hexyl)-ethanol, 2,2-dimethyl-3-(3-methylphenyl)-propanol, pt-butylcyclohexanol, ot-butylcyclohexanol, ambricol, benzyl alcohol , phenylethyl alcohol, phenoxyethanol, ethyl phenylethanol, etc. Classes, methyl dihydrojasmonate, tetrahydroindenyl 3-mercaptopropionate, Kovanol, geranium oil, birch oil, ermo eucalyptus, pentyl cinnamaldehyde, allyl pentanyl Alkylate, β-ionone, isobutylquinoline, nerol oxide, 6,7-epoxy-3,7-dimethyl-1,3-octadiene, rose oxide, white Lemon ring ether, peppermint, linalool oxide, butyl dimethyl dihydropyran, ethoxylated pentyl tetrahydropyran, cedar methyl ether, methoxy cyclododecane, 1 -Methyl-1-methoxycyclododecane, ethoxymethylcyclododecyl ether, tricyclodecenyl methyl ether, Lubao Fex, Cedroxide, aurantane, Glycerba, Paul洼基里斯, anisole, dimethyl hydroquinone, p-cresol methyl Ether, acetaminophen, anethole, dihydrofenosamine, diphenyl oxide, methyl syringol, methyl iso-syringyl, benzyl iso-eugenol, phenylethyl isoamyl ether, δ -naphthylmethyl ether, δ-naphthylethyl ether, δ-naphthyl isobutyl ether, 2,4-dimethyl-4-phenyltetrahydrofuran, perylene, 2,2,5,5- Synthetic flavors such as tetramethyl-4-isopropyl-1,3-dioxane, various synthetic oils, natural flavors, and various blending flavors.

(pigment)

In terms of pigments, lipophyllin, crocin, capsanthin, perilla, hibiscus, grape skin extract, baicalein, cocoa pigment, laconic acid, citric acid, curcumin, beetin, red Rhodamine, hematoxylin, caramel, safflower, scorpion pigment, comfrey, carmine pigment, scorpion, anthocyanin, chalcone, carotenoid, flavonoid, flavin Natural coloring materials such as pigments, benzoquinone, purple, diketone, and anthocyanin pigments, photoreceptor No. 101, photoreceptor No. 201, photoreceptor No. 301, and photoreceptor No. 401 , red 2, red 3, red 102, red 104, red 105, red 106, red 201, red 202, red 203, red 204, red 205, red 206, red 207, red 208, red 213, red 214, red 215, red 218, red 219, red 220, red 221, red 223, red 225, red 226, red 227 , red 228, red 230, red 231, red 232 Orange No. 201, Orange No. 203, Orange No. 204, Orange 205 No., Orange 206, Orange 207, Yellow 4, Yellow 5, Green 3, Green 201, Green 202, Green 204, Green 205, Yellow 201, Yellow 202, Yellow 203 No., yellow 204, yellow 205, yellow 401, yellow 402, yellow 403, yellow 404, yellow 405, yellow 406, yellow 407, green 401, green 402, blue 403 , purple 401, black 401, blue 404, red 401, red 404, red 405, red 501, red 502, red 503, red 504, red 506, orange 401 , Orange 402, Orange 403, Red 505, and Blue 1, Blue 2, Blue 201, Blue 202, Blue 203, Blue 204, Blue 205 An organic pigment powder such as a brown 201, a purple 201, a zirconium, a hafnium or an aluminum lake, and a natural pigment such as a comfrey pigment or a safflower pigment or an organic synthetic pigment.

(preservative or fungicide)

Examples of the preservative or the bactericide include phenol, p-chlorophenol, p-chloro-m-cresol, p-chloro-meta-dimethyl phenol, resorcin, resorcinol monoacetate, ortho-phenylphenol, Isobutyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, sodium ethylparaben, butyl p-hydroxybenzoate, sodium butylparaben, propyl Para-oxybenzoic acid alkyl esters such as p-hydroxybenzoate, sodium propyl paraben, methyl paraben, sodium methyl paraben, phenoxyethanol , phenols such as thymol, cresol, indophenol ketone, hydroxybenzenethiol, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, dehydroacetic acid and its salts, 2,4,4 '- trichloro - 2' - hydroxy diphenyl ether, hexachlorobenzene, alcohol sulfate double dichlorobenzene, halogenated bisphenols, 3,4,4 '- trichloro-benzene carbonyl amine, 3-trifluoromethyl 4,4 ' -dichlorocarbonylamine benzene, 3,4 ' , 5-tribromolyl anilide, p-aminophenyl sulfonated decylamine, undecylenic acid monoethanol amide, etc. Amidoxime, benzalkonium chloride a 4-grade ammonium compound such as an alkylisoquinolinium bromide, a benzethonium chloride chloride, a cetylpyridinium chloride, a chlorhexidine chloride or an alkyltrimethylammonium chloride; a two-ionic surfactant such as alkylaminoethylglycine, chlorinated hydroxyethyl hydroxyethyl betaine, crosinidine gluconate, tetramethyl thiuram disulfide, sensitizing Photoreceptors such as No. 101, Photoreceptor No. 201, Photosensitive No. 301, Photoreceptor No. 401, Photoreceptor NK-143, 1-hydroxypyridine-2-thione (zinc pyrithione), imidazolinyl Urea, N-trichloromethyl. Mercapto-4-cyclohexene 1,2-dicarboxylinyl quinone imine, chlorinated lysozyme, chlorophenyl glycol ether, chlorobutanol, 2-bromo-2-nitro-1,3-propane diol, Sharp-toothed fennel oil, sea lion oil, citronellol, syringol, benzyl alcohol, ethanol, 1,3-butanediol, hexanediol, dipropylene glycol, glycerin, 1,2-propanediol, 1,2 -butanediol, 1,2-pentanediol (pentanediol), 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2 - an alcohol such as decanediol or 1,2-decanediol, p-chloro-m-cresol, cloxadesidine chloride, bis(2-pyridylthio-1-oxide) zinc, Dimethyl sulfonium, isopropyl methyl phenol, 6-ethoxycarbonyl-2,4-dimethyl-m-dioxane, 5-chloro-2-methyl-4-isothiazolin-3- Ketone, 2-methyl-4-isothiazolin-3-one, chlorine, sodium hypochlorite, bleaching powder, iodine, formaldehyde, glutaraldehyde, diethyl pyrocarbonate, ethylene oxide, β-propiolactone, hydrogen peroxide Water, sulfur, potassium gluconate, DMDM carbendazim, alkyl (C12-14) diethylaminoethylglycine hydrochloride, quaternary ammonium salt-80, quaternary ammonium salt-87, chloramine T , isopropyl toluene-5-ol, propylaminopropyl propyl iodide, Aminopropyl biguanide, methylisothiazolinone, methyl chloride isothiazolin-one iodide, dimethylamino methyl styrene heptyl thiazolium like. Also, the narrow leaf false blue thorn leaf essence, sassafras essence, olive leaf essence, orange juice, Artemisia essence, licorice flavonoids, Vicki's bear bamboo essence, grapefruit essence, chlorine Plant extracts such as phenylglycol, honeysuckle essence, phenoxyethanol, saxifrage essence, and mantle essence are also useful as antibacterial agents.

Among the above antibacterial agents, in particular, non-p-oxybenzoate-based antibacterial agents such as 1,2-alkanediol or 1,3-butanediol are low in irritation to the skin and have high antiseptic effect. The point of moisturizing is preferred. The 1,2-alkanediol is preferably a 1,2-alkanediol having a carbon number of 4 to 10, particularly 1,2-pentanediol (pentanediol) and 1,2-hexane. One or two or more kinds of 1,2-alkanediols selected from alcohol, 1,2-heptanediol and 1,2-octanediol, and the phase of ascorbic acid 2-glucoside or its sodium salt The solubility is particularly excellent and can be advantageously used.

(UV absorber)

As the ultraviolet absorber, an amine benzoic acid, a p-aminobenzoic acid monoglyceride, an N,N-dipropoxy p-amino benzoic acid ethyl ester, and an N,N-diethoxy-p-amine can be exemplified. An amino-based benzoic acid-based ultraviolet absorber such as ethyl benzoate, ethyl N,N-dimethyl-amino benzoate, or N,N-dimethyl-amino benzoic acid butyl ester, O-amine benzoic acid ultraviolet absorber such as menthol-N-acetic acid benzoate, cinnamic acid, oxybenzone-3, oxybenzone-4, oxybenzone-5, oxybenzone a benzophenone derivative or a 1,3-propanedione derivative of -9 or the like having a sugar or sugar alcohol-bonded sugar-based ultraviolet absorber, salicylic acid and a sodium salt thereof, pentyl salicylate, Mentholyl salicylate, menthol salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Salicylic acid ultraviolet absorber such as salicylic acid dipropylene glycol, octyl cinnamate, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, Base-2,4-diisopropylcinnamate, methyl-2,4- Isopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl P-methoxycinnamate, 2-ethoxyethyl-p-methoxycinnamate (cinofloxacin), cyclohexyl-p-methoxycinnamate, ethyl-α-cyanide Benzyl-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octyl cyanide), glyceryl mono-2-ethylhexyl-diyl Cinnamate-based UV absorbers such as methoxycinnamate, ferulic acid and its derivatives, 2,4-dihydroxybenzophenone, 2,2 ' -dihydroxy-4-methoxybiphenyl Ketone, 2,2 ' -dihydroxy-4,4 ' -dimethoxybenzophenone, 2,2 ' ,4,4 ' -tetrahydroxybenzophenone, 2-hydroxy-4-methoxy benzophenone, 2-hydroxy-4-methoxy-4 '- methyl benzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone benzophenone, 2-ethylhexyl-4 '- phenyl - benzophenone-2-carboxylate, 2-hydroxy -4-n- octyloxy benzophenone, 4-hydroxy-3-carboxy benzophenone of benzophenone ultraviolet absorbers, 3- (4 '- methyl benzylidene Yl) -d, l- camphor, 3-benzylidenecamphor -d, l- camphor, 2-phenyl-5-methyl-benzoxazole, 2,2 '- hydroxy-5-methylphenyl phenyl benzotriazole, 2- (2 '- hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2' - hydroxy - 5 '- methylphenyl benzotriazole, dibenzaldehyde hydrazine, di-p-methoxy benzoyl methane, 5- (3,3-dimethyl-2-norbornyl-ylidene) -3-pentan-2-one, 4-methoxy -4 '-t Imidazoles such as butylbenzhydrylmethane, 4-t-butylmethoxybenzhydrylmethane, etc., octyltriazinone, imidazole acrylate, and imidazolium acrylate acrylic acid derivatives, 2- (2 '- hydroxy - 5' - methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1, 3-pentanedione, dimethoxybenzylidene dioxoimidazolyl propionate octyl, dimethoxybenzylidene dioxoimidazolyl propionate 2-ethylhexyl, etc. Derivatives, phenyl benzimidazole sulfonic acid, p-xylylene dicamphorsulfonic acid, cresol triazole, methyl o-amine benzoate, rutin and its derivatives, rice sterol and Derivative, octyl dimethyl-p-aminobenzoic acid Ester, titanium oxide, zinc oxide, kaolin, talc, ethylhexyl triazinone, octyl cyanide, dimethyl PABA octyl, humulizate, methylene bisbenzotriazolyl tetramethyl Butyl phenol, ethylhexyl methoxycinnamate, octyl methoxycinnamate, and the like.

(metal blocking agent)

The metal blocking agent may, for example, be an ethylenediaminetetraacetate such as ethylenediaminetetraacetic acid (EDTA), EDTA2 sodium, EDTA3Na or EDTA4Na, or a hydroxyethylethylenediyl salt such as hydroxyethylethylenediaminetriacetic acid trisodium salt. Amine triacetate, tripolyphosphoric acid, diamethylenetriamine pentaacetate, phytic acid a salt of a phosphonic acid such as etidronate or a sodium salt thereof, a polyamino acid such as sodium oxalate, polyaspartic acid, polyglutamic acid, sodium polyphosphate, sodium metaphosphate or phosphoric acid , pyrophosphate, hexametaphosphate, sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, succinic acid, tartaric acid, and the like.

(buffering agent)

Examples of the buffer (pH adjuster) include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, potassium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, and hydrochloric acid. Sulfuric acid, boric acid, borax, nitrogen triethanol, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2 -Amino-2-hydroxymethyl-1,3-propanediol, arginine, ammonium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, potassium hydrogen phosphate ammonia, cesium carbonate, Ammonium carbonate, sodium carbonate, potassium carbonate, potassium bicarbonate, sodium bicarbonate, magnesium oxide, calcium oxide, ammonium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, potassium phosphate, magnesium phosphate, calcium phosphate, sodium borate, Sodium metaborate, potassium citrate, and the like.

In particular, the lotion containing the external composition for skin of the present invention may be combined with sodium citrate, glycolic acid, succinic acid, sodium monohydrogen phosphate, sodium dihydrogen phosphate, sodium hydroxide, which are widely used in the field of cosmetics. One or two or more kinds of buffers selected from potassium hydroxide, in particular, the pH of the lotion to be used in the present invention is usually pH 5 to 9, preferably pH 6 to 8, more preferably pH 6.5 to 7.5. The range of the range is good.

<washing agent>

The skin external composition of the present invention can be used as a facial cleanser by blending a component having a detergency effect. For the dirt on the skin, there is a dirty matter caused by the original physiological action of the skin, that is, the sebum membrane is rancid, the deteriorating person and the stratum corneum are peeled off, and there is dust in the air, etc. It is a combination of dirty and hygienic cosmetics and daily-use cosmetics. The facial cleanser is used almost daily for the purpose of washing off the skin and keeping the skin clean. Specific examples of the facial cleanser include soap, body lotion, facial cleansing cream, and makeup remover. The component having a washing action is an alkali salt (soap) of a higher fatty acid, and the alkali salt of a higher fatty acid is mainly a sodium salt, a potassium salt or an amine salt of a C ₁₀ -C ₁₈ fatty acid.

In the facial cleansing agent, one or more selected from the group consisting of a fragrance, a coloring matter, an antioxidant, and a metal blocking agent may be further blended for the purpose of improving the quality and stability. These are generally the quality of the facial cleanser per unit of the present invention. The blending is carried out in a range of 0.0001% by mass or more, preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass, still more preferably 0.1 to 10% by mass. The fragrance, the pigment, and the metal blocking agent can be applied to those detailed in the aforementioned lotion. As the antioxidant, for example, the antioxidant described below can be applied.

(Antioxidants)

In terms of antioxidants, vitamin A such as retinol, dehydroretinol, retinyl acetate, retinyl palmitate, retinal, retinoic acid, vitamin A oil, and the like can be exemplified. And carotenoids and derivatives thereof, such as salt, α-carotene, β-carotene, γ-carotene, cryptoxanthin, astaxanthin, phycoxanthin, pyridoxine, pyridoxal , pyridoxal-5-phosphate, pyridoxamine and the like vitamin B, such derivatives and such salts, ergot calciferol, cholecalciferol, 1, 2, 5-dihydroxy- Vitamin D such as cholecalciferol, such derivatives and salts thereof, α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-parallel double bond regenerator, β - Vitamins of the double bond reproductive phenol, γ-parallel double bond reproductive phenol, δ-parametric double bond reproductive phenol, acetic acid tocopherol, nicotinic acid tocopherol, etc., such derivatives and the salts thereof, water soluble Torolox, its derivatives and such salts, dihydroxytoluene, butylhydroxytoluene, butylhydroxyanisole, dibutylhydroxytoluene, alpha-lipoic acid, dehydrolipoic acid , glutamine-based sulphur, derivatives thereof, and the like, succinic acid, erythorbic acid, sodium erythorbate, and the like, ascorbic acid, derivatives thereof, and salts thereof, gallic acid, gallic acid propyl, etc. Gallic acid, a derivative thereof, and a rutin such as a salt, a rutin, an α-glycosyl-rutin, a derivative thereof, a salt thereof, a tryptophan acid, a derivative thereof, and the like , histidine, its derivatives and the salts thereof, N-acetyl cysteine, N-acetyl cystein, N-octyl cysteine, N-acetyl cystein cysteine derivatives and salts of such esters, etc., N, N '- diacetyl two cysteine dimethyl ester, N, N' - dioctyl acyl cysteine dimethyl ester, N, N a cystine derivative such as di-octyl-mercapto-methionine dimethyl ester, and the like, salts, carnosine and derivatives thereof, and salts thereof, levokinosine and derivatives thereof, and the salts and myopeptides And derivatives thereof and salts thereof, carnosine and derivatives thereof, and salts thereof, dipeptides or tripeptide derivatives containing histidine and/or tryptophan and/or histamine and such Salt, flavanone, flavonoids, flowers , anthocyanin, flavonol, quercetin, quercetin, myricetin, quercetin, witch hazel tannin, catechin, epicatechin, gallocatechin, table Flavonoids, tannic acid, caffeic acid, ferulic acid, protocatechuic acid, such as gallocatechin, epicatechin gallate, epigallocatechin, gallic acid, etc. , chalcone, rice sterol, carnosol, sesame phenol, sesamin, sesamelin, zingerone, curcumin, tetrahydrocurcumin, (3,4-dihydroxyphenyl)acrylamido)propionic acid , deoxy(3,4-dihydroxyphenyl)acrylamido)propionic acid, gingerol, capsaicin, vanillylamine, citric acid, bromophenol, vasomycin, molasses, riboflavin , riboflavin tyrosinate, flavin mononucleotide, flavin adenine nucleotide, ubiquinone, panthenol, mannitol, bilirubin, cholesterol, 2-phenyl benzisoselazole-3-one, selenium Methionine, ceruloplasmin, transferrin, lactoferrin, albumin, superoxide dismutase, catalytic enzyme, glutamine thioperoxidase, metallothionein, thiol redox protein, sulfur Taurine, O-phosphonium-pyridinyloxypyranyl, and N-(2-hydroxybenzyl)amino acid, derivatives thereof, and the like, and N-(4-pyridyloxy) Amino acid, its derivatives and such salts, lysine, 1-methionine, valine, silymarin, tea extract, grape bark/seed extract, melanin, rosemary Fragrant extracts, etc.

(other ingredients)

Further, one or two or more selected from the group consisting of glycerin, ethanol, granulated sugar, polyhydric alcohol, and bactericide may be further blended. In terms of fungicides, although suitable It is used as a preservative and a bactericide as described in the above-mentioned lotion, but in the case of a soap-based detergent such as a face-washing agent, the purpose of disinfection, sterilization, and deodorization is to use cloxazepine hydrochloride. , isopropylmethylphenol, photoreceptor No. 101, cresol, chloroxylenol, trichlorocarbonylamine benzene, halocarban, phenol, chlorocresol, phenoxyethanol, trichlorohydroxydiphenyl ether, etc. It is better.

<Beauty solution>

The skin external composition of the present invention can be used as a cosmetic liquid by blending a moisturizing agent and a softening agent. In general, the cosmetic liquid is a cosmetic having a viscosity, a feeling of use, and a moisturizing property, and is considered to have a moisturizing function and a softening function. In the case of humectants and softeners, it is applicable to those already mentioned in the lotion. The dosage form is known to be a solubilized type, an O/W emulsified type, or an oil type.

In general, the beauty liquid can be further blended with one or more selected from the group consisting of a fragrance, an ultraviolet absorber, a whitening agent, an anti-inflammatory agent, a preservative, and a bactericide, and has a moisturizing function and a softening function. The functioner. Among the above-mentioned blending components, the perfume, the ultraviolet ray preventing agent, the preservative, and the bactericide are preferably those which are described in detail in the above-mentioned lotion. In the case of a whitening agent and an anti-inflammatory agent, for example, a whitening agent and an anti-inflammatory agent described below are preferably used.

(whitening agent)

Further, as a whitening agent, 3-methoxysalicylic acid, 3-ethoxysalicylic acid, 4-methoxysalicylic acid, 4-ethoxysalicylic acid, 4-propoxy group can be exemplified. Salicylic acid, 4-isopropoxysalicylic acid, 4-butoxysalicylic acid, 5-methoxysalicylic acid, 5-ethoxysalicylic acid, 5-propoxysalicylic acid, etc. Alkoxy salicylic acid and its salts, hydroquinone, arbutin, α-arbutin, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D -galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, hydroquinone α-D-ribose, p-phenylene Phenol β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-arabinose, pair Hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L -glucosamine, hydroquinone β-L-glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine , hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuronic acid, hydroquinone α-L-glucuronic acid, pair Hydroquinone β-L-Port Uronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L a hydroquinone such as galacturonic acid or the like, such as a hydroquinone or a glycoside thereof, a hydroquinone derivative, a tranexamic acid or a derivative thereof, and the like, a salt thereof, and an isophthalic acid. a resorcinol derivative such as diphenol or 4-n-butyl resorcinol, citric acid or a derivative thereof, and the like, a salt of citric acid or linoleic acid, and a salt thereof Tooth fennel extract, Polygonum cuspidatum (polygonum cuspidatum root) extract, eucalyptus extract, cassia extract, cassia seed extract, astragalus extract, yellow sassafras extract, maple leaf slab (including root) extract, Sheep Brings (Xianzi) Extract, Ghost Super Mail (Tianma) Extract, Pyracantha Extract, Big Man Polygonum cuspidatum extract, Tiantai medicinal herb extract, pumpkin extract, Typha angustifolia extract, scorpion scorpion (Ganzi) extract, Aquilaria sinensis extract, scorpion extract, black cloud Grass extract, Qiongma extract, Xiandao Clematis extract, Clematis extract, Buttercup (Wuling) extract, Oshima Sakura extract, Dashan Sakura extract, Bean Sakura extract, Kaolin Sakura extract , Sakura sakura extract, Sakura extract, Japanese sable (Aster) extract, palm extract, white flower iris extract, celestial grass (Da 蓼) extract, willow magnolia (Xinyi) extract, tooth tiger Ear extract, evening primrose extract, root extract, dodder extract, dodder extract, bitter extract, valerian extract, white peony extract, dill extract, Eight-salt Polygonum cuspidatum extract, alfalfa extract, sarcophagus (Dendrobium) extract, Jixiangpu (Typha) extract, thorn pine extract, plant Blanca extract, Hamra extract, Amaranthus extract, Western bowl of flower extract, sandalwood extract, ganoderma extract, fine Motherwort extract, silver willow extract, glandular willow extract, pussy willow extract, Tamarix extract, Tamarix extract, Kozao willow extract, Twigs willow extract, Lingliu extract, and mountain willow extract , Euonymus japonicus extract, Chinese Tamarix extract, foxtail extract, sweet poplar extract, bayberry (yangmei) extract, agave extract, green agave extract, covered agave extract, Sancha Extract, Dendrobium extract, Brassica napus extract, Brassica extract, Spirulina extract, Brassica extract, Dendrobium extract, Laminaria extract, True kelp extract, Lithium Khumbu extract, kelp extract, kelp extract, wakame extract, broadleaf wakame extract, green wakame extract, sargassum extract, stag beetle extract Phyllostachys pubescens extract, Phyllostachys pubescens extract, Spirulina gracilis extract, Spirulina gracilis extract, Spirulina gracilis extract, Spirulina platensis extract, Japanese sphaerophyte extract, Small sphagnum extract, Stalk fan Algae Extract, Sawtooth Eucheuma Extract, Licorice Eucheuma Extract, Eucheuma Extract, Cypress Eucheuma Extract, Carrageenan Extract, Heterocarpic Extract, Japanese Carrageen Extract, Vanilla Carrageenan extract, Rhizoctonia solani extract, Rhododendron chinensis extract, Algae extract, Net wing algae extract, Membrane pteridophyte extract, Forked Solanum extract, Wave algae extract, Japanese wave algae extract, S. cerevisiae extract, S. cerevisiae extract, S. cerevisiae extract, Sagitda serrata extract, Dark Sargasso extract, Sargasso algae extract, Sargassum Extract, Branched Sargasso Extract, Sargasso Extract, Sargassum Extract, Algae Extract, Skeleton Extract, Nitragen Extract, Algae Extract, Haibai Extract, Zhenjiangwan extract , horn net algae extract, Phyllostachys pubescens extract, Phyllostachys pubescens extract, O. sylvestris extract, Xenopus extract, A. faecalis extract, P. argyi extract , Rhododendron chinensis extract, algae extract, Tila extract, Camotede Azafran extract, Rosemary extract, Poleo Verde extract, Navo Negro extract, Artemisia argyi extract, Sargassum extract, pod Torrema extract, big horsetail algae extract, large leaf cohosh extract, placenta extract, resveratrol, silk extract, acacia extract, West Indian cherry extract, castor (winter) Extract, silver birch extract, gallnut extract, chestnut extract, turfgrass extract, black flower marguerite extract, marguerite extract, cress extract, buckwheat extract, fucus extract Object, Amaranth extract, Tasmania zealand extract, mulberry extract, hazelnut extract, angelica extract, mantle extract, Sophora flavescens extract, Artemisia extract, Lonicera japonica extract, Taiwan sassafras extract, Houttuynia cordata extract, alfalfa extract, alfalfa extract, stalk extract, sedge extract, wild hawthorn extract, eucalyptus extract, yarrow extract, eucalyptus extract, cinnabar extract , Vitex negundo extract, witch hazel extract, mulberry extract, platycodon grandiflorum extract, continuous stalk extract, dry extract, ephedra extract, Chuanxiong extract, hairy angelica extract, thorn extract , wind extract, sea breeze extract, scutellaria extract, peony bark extract, peony extract, yak seedling extract, puerarin extract, licorice extract, gallnut extract, aloe extract, cohosh extract , safflower extract, green tea extract, black tea extract, medicinal extract, chamomile extract, bluegrass extract, oil-soluble licorice extract, xiheliu essence, saxifrage essence Plant essence, phenyl mercury hexachlorobenzene, oxidized mercury, mercuric chloride, hydrogen hydrogen peroxide, zinc perchlorate, 2-aminophenol and its derivatives, ferulic acid and its derivatives, placental essence, Gluten-based sulfur, rice sterol, butyl resorcinol, and the like.

(anti-inflammatory agent)

Further, in terms of an anti-inflammatory agent which can be blended into the cosmetic liquid of the present invention, beretic acid cortisol, propofol cortisol, flutica cortisol, and cortisol-21-propionate can be exemplified. , propionic acid derivatives such as hydrocorticosterone cyclopentyl propionate, bet cortisol dipropionate, allantoin, allantoin acetaminophen-dl-methionine, allantoin pentahydroxychlorinated Aluminum, allantoin dihydroxy Allantoin or its derivatives of aluminum, allantoin polygalacturonic acid, glycyrrhizic acid, glycyrrhizic acid, allantoin glycyrrhizin, glycyrrhizic acid glycyrrhizic acid, stearic acid glycyrrhizic acid, glycyrrhizin stearate , glycosylic acid or its derivatives, pantothenic acid, panthenol, panthenol ethyl ether, benzhydryl panthenolyl B, etc. Base ether, calcium pantothenate, sodium pantothenate, ethenyl panthenol ethyl ether, panthenol ethyl ether of benzoic acid, pantothenic acid derivatives such as panthenol, alpha-tocopherol, beta-tocopherol, gamma - tocopherol, nicotinic acid tocopherol, acetic acid tocopherol, linoleic acid tocopherol, ferulic acid tocopherol, tocopherol phosphate, etc. tocopherol derivatives, ginseng double bond regenerator, vitamin E acetate, amber Vitamin E or its derivatives such as acid tocopherol, 2-aminophenol and its derivatives, acetic acid derivatives such as sulindac, dichlorophenic acid, fenbufen, pyridoxine hydrochloride, menthol, biological , camphor, turpentine, zinc oxide, strontium, guaiac and its derivatives, mefinic acid and its derivatives, mefenamic acid Its derivatives, phenylbutazone and its derivatives, indomethacin and its derivatives, ibuprofen and its derivatives, biphenylcarboxylic acid derivatives, oxicam, salicylic acid, acetamidine Salicylic acid, nalpromazine, phenoxaprofen, flupiprofen, fampprofen, cepprofen, pyripramine, capprofen, dibenzoxazole propionate, pula Lofen, meloprofen, thioprofen, spproprofen, aminprofen, tirolprofen, fluprofen, ketoprofen and its derivatives, ε-amino-lanoleic acid, double Sodium chlorate, diphenylhydroxylamine, tranexamic acid and its derivatives, corticosterone and its esters, cortisol and its esters, prednisone, penicol cortisol and other renal cortical hormones, antihistamine Agent, boric acid, azaprozin, bromfenac, celecoxib, dipyridamidine, diflunisin, eddorec, flufenamic acid, ketorolac, meloprofen Salt, memphinamid, meloxima, nabumetone, pilocarpine, budebufen, rofecoxib, toltestine, triclofenac, clofibrate, double Phenylhydroxylamine hydrochloride, chlorpheniramine maleate, corticosteroids, cortisol, glucocortisol, flumetasone, cortisol, cortisol-21-monoester, cortisol-21- Acetate, cortisol-21-butyrate, cortisol-21-valerate, cortisol-17,21-diester, cortisol-17,21-diacetate, hydrogenated cortex Keto-17-acetate-21-butyrate, cortisol-17,21-dibutyrate, methylprene cortisol, benzoic acid belat Cortisol, diflupirone diacetate, fluro Cortisol, carbamazepine, topical corticosteroids, hydroxytean cortisol, alpha-methyl glucocorticol, glucocorticol phosphate, clofibrate cortisol, dextromethorphan, deoxygenated Rice pine, deoxycorticosterone acetate, diclofens, diflurane diacetate, diflucone gibberellate, fluoroadrenal ketone, flucloxamid, fludrocortisone, flumetasone trimethylacetate , Ketoflucal cortisol, flucoutin butyl ester, fluconazole, flutidine (fluoroptera), fluorohydrogenated sulphonate, hassinide, cortisol acetate, cortisol butyrate, tean Cortisol propyl ketal, cortonolone, fluoroacetal, medroxyprogesterone, amoxicillin, anciceptrol, bet Cortisol, prednisone, prednisone acetate, clodrosol, kesi Nandrolone, difluprednate, flucline, flunisolide, dexamethasone, fluoropyrine, fluprednisolone, cortisol gibberellate, hydrocortisone, methylprednisolone, parramexone , Corianol, Essoxicol, Texicon, Shudoxicam, CP-14, 304, True Aloe, Plant Sterol, Plant Sterol, Bluegrass, Aster, Hydrangea, European Hollyhock, Rhododendron, aloe, boxing, biting cat, camping, narrow-leaf fake blue thorn, fragrant tea, Yu Gold, Astragalus, Barley, Small Forsythia, Orange, Valerian, Birch, Chamomile, Radish, Artemisia scoparia, Licorice, Courgette, Honeysuckle, Guggal, Scorpion, Vicki's Bear Bamboo, Watercress, Dragon Gallbladder, yak seedlings, cola fruit, burdock, fin glass grass, Wujia, Scrophulariaceae extract, a string of red, Brazilian pepper, medlar, comfrey, perilla, peony, white birch, sage, western small Forsythia, Ivy, Western Juniper, Yarrow, Western Mint, Chuanxiong, Swertia, Mulberry, Jujube, Thyme Thyme, Chinese Parsley, Leigonggen, Winter Melon, Peach Kernel, Houttuynia, Ocean Potentilla, indigo, tea, angelica, calendula, elderberry, carrot, parsley, mint, sandalwood, alfalfa, fake leaf tree, grape, broccoli, safflower, scutellaria, linden, peony, valerian, European seven Ingredients such as leaf tree, sapindus, whip coral extract, purple duck grass, evening primrose, peach, cornflower, eucalyptus, genus, bayberry, lavender, roman chamomile, rosemary, etc. And such mixtures.

In particular, in the case of a cosmetic liquid in which the external composition for skin of the present invention is blended, glycyrrhizic acid such as stearic acid glycyrrhizinate or dipotassium glycyrrhizinate derived from a natural component, which is an anti-inflammatory agent, or an anti-inflammatory agent thereof, or Derivative, gentian essence, perilla essence, sage essence, western elderberry essence, thunder root essence, houttuynia essence, angelica essence, peony essence, evening primrose essence, sapindus essence One or two or more kinds of Saxifrage essence, Ai's essence, and apple essence are preferred. These are usually blended in a range of 0.0001% by mass or more, preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass, still more preferably 0.1 to 10% by mass, based on the mass unit of the cosmetic liquid of the present invention. .

<emulsion>

The skin external composition of the present invention is obtained by using an aqueous medium as a base and blending an oily component and a surfactant to form an emulsion. The purpose of the lotion is to clean the skin, remove makeup, protect the skin, moisturize and soften, and promote blood circulation. In addition to the special case, the emulsion is a liquid emulsion because the oil phase is less than the cream, so the alias is also called "liquid cream". The emulsified type is O/W type and W/O type, but it is generally O/W type, and the ratio of the water phase is large. When applied to the skin, it can be stretched lightly to give a refreshing feeling. As for the oil component and the surfactant, various components detailed in the above-mentioned lotion can be suitably used.

In the emulsion of the present invention, one or more selected from the group consisting of a moisturizing agent, a softening agent, a blood promoting agent and a high molecular substance may be blended in accordance with the purpose and function, and the emulsion of the present invention is usually used in each case. The mass unit is blended in a range of 0.0001% by mass or more, preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass, still more preferably 0.1 to 10% by mass. In the case of the humectant and the softener, various components detailed in the above-mentioned lotion can be appropriately blended. In the blood cell promoter and the polymer material, for example, a blood cell promoter and a polymer material described below can be appropriately blended.

(blood activator)

In terms of blood promoting agents, it can be exemplified from sauerkraut, carrot, and silver. Apricot, biting cat, ginger, garlic, tomorrow leaves, rabbits, apricots, fennel, fragrant tea, small forsythia, thorn flower, Dutch cockroach, medlar, chamomile, Roman chamomile, raspberry, cinchona,虞美人, Kushen, gentian, laurel, pingzhu grass, burdock, rice, a bunch of red, Brazilian pepper, wild hawthorn, shiitake mushroom, rehmannia, persimmon, peony, ginger, calamus, western wild hawthorn, monkey horse chestnut , Western juniper, Chuanxiong, orange, thyme, thyme, clove, pepper, angelica, calendula, peach kernel, spruce, houttuynia, juniper, peppermint, coaster, witch hazel, fake leaf tree, grape, linden Law, peony, pine, horse chestnut, rosemary, lemon balm, grass hibiscus, grapefruit, medlar, coix seed, lavender, yellow gentian, rosemary, rose hip, tangerine peel, peach, walnut, Plants, calamus root, aloe vera, bayberry, eucalyptus, genus and other plants, hesperidin, glycosaminoglycan, rutin, sugar transfer rutin, acetylcholine, methyl trimethylamine butyrate , bishydroxyhydroxylamine hydrochloride, γ-mysterol, l-menthol,千金金素, vitamin E, δ-tocopherol, α-tocopherol, tocopherol acetate, linoleic acid tocopherol, nicotinic acid methyl ester, nicotinic acid tocopherol, succinic acid tocopherol, vitamin E nicotine A vitamin E derivative such as an acid ester, minosinide, niacinamide, vanillyl methacrylate, carbonic acid gas or the like.

(high molecular substance)

Further, in the case of an emulsion, in general, a polymer substance is added in advance to the aqueous phase for the purpose of protecting the gum. Examples of the polymer material include a carboxyvinyl polymer, a trisin, an acrylic polymer, and a carboxyl group. Sodium methyl cellulose (CMC) and the like.

<cream>

The skin external composition of the present invention is based on an aqueous medium and is blended with an oily component and a surfactant to form a cream. In the case of the emulsified type, as in the case of the emulsion, there are both O/W type and W/O type. However, since the cream generally has more oil phase than the emulsion, it is an emulsion having no fluidity. The purpose of the cream is to clean the skin, remove makeup, protect the skin, moisturize and soften, and promote blood circulation of the skin, similarly to the lotion. More specifically, a cleansing cream, a softening cream, a nourishing cream, a night cream, a base cream, a dispersing cream, a moisturizing cream, a massage cream, a cold cream, a lip care cream, and the like can be given.

As for the oily component and the surfactant used in the cream, various components described in the above-mentioned lotion can be applied. Further, in the cream, one or two or more kinds selected from the group consisting of cetyl wax, cetyl alcohol, lanolin, mobile paraffin, petrolatum, glycerin, and squalane may be further blended as an auxiliary component of the oily component. It is blended in a range of 0.0001% by mass or more, preferably 0.001 to 50% by mass, more preferably 0.01 to 25% by mass, still more preferably 0.1 to 10% by mass, based on the mass unit of the cream of the present invention.

<Other ingredients>

In addition to the above various components, the skin external composition of the present invention or the lotion, the facial cleanser, the cosmetic liquid, the lotion, or the cream may be appropriately added to other components as generally used. example For example, the tackifiers, vitamins, amino acids, anti-wrinkle agents, seaweed extracts, cell activators, percutaneous absorption enhancers, foaming agents, solubilizing agents, keratolytic agents, hormones described below Classes, pigments, plasticizers, inorganic powders, organic powders, and the like.

(tackifier)

Examples of the tackifier include guar gum, locust bean gum, kunse seed, carrageenan, galactose, gum arabic, tara gum, sour bean, red algae gum, karaya gum, geranium, Carrageenan, tragacanth, pectin, pectic acid and sodium salt, salt of alginic acid and sodium salt, mannan, rice, corn, potato, wheat, starch, dextrin, Sanxian gum , dextran, succinyl polyglucose, carterin, hyaluronic acid and its salts, xanthan gum, pullulan, yam, chitin, chitin, cold weather, brown algae essence, chondroitin sulfate , casein, collagen, gelatin, albumin, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose and sodium thereof, methyl hydroxy propyl Cellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose and other derivatives thereof, soluble starch, carboxymethyl starch, methyl hydroxypropyl starch Starch polymer such as methyl starch, hydroxypropyl chloride Starch derivatives such as methylammonium starch, octenylsuccinic acid corn starch aluminum, alginic acid derivatives such as propylene glycol alginate, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinyl pyridinium ketone. Vinyl alcohol copolymer, vinyl alcohol. Vinyl acetate copolymer, polyvinyl methyl ether, polyethylene glycol, polypropylene glycol, polyoxyethylene. Gather An oxypropylene copolymer, a (methacryloyloxyethylcarboxycarboxybetaine/alkyl methacrylate) copolymer, and an (acrylate/stearate/ethyl methacrylate) copolymer Methacrylate copolymer, (dimethyloxane/vinyl dimethyl decane) interactive polymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone propylene) Indoleamine copolymer AMP, polyvinyl acetate partial saponification, maleic acid copolymer, polyvinylpyrrolidone, vinyl pyrrolidone. Dialkylaminoalkyl methacrylate; acrylic resin alkanolamine, polyester, water-dispersible polyester, polypropylene decylamine, polyacrylate copolymer, etc., carboxyvinyl polymer , polyacrylic acid and its sodium salt, etc., acrylic acid. Methacrylate copolymer, acrylic acid. Alkyl methacrylate copolymer, polyquaternium-10, etc., cationized cellulose, polyquaternium-7, etc. diallyldimethylammonium chloride. Acrylic amide copolymer, polyquaternium-22 and other acrylic acid. Diallyl dimethyl ammonium chloride copolymer, polyquaternium-39 and the like acrylic acid. Diallyldimethylammonium chloride. Acrylamide copolymer, acrylic acid. Cationized methacrylate copolymer, acrylic acid. Cationic methacrylate methacrylate copolymer, polyquaternium-47 and other acrylic acid. Methyl acrylate. Methyl propylene decyl propyl trimethyl ammonium copolymer, choline methacrylate choline polymer, cationized oligosaccharide, cationized dextran, guar hydroxypropyl trimethyl ammonium chloride Such as a cationized polysaccharide, a polyethyleneimine, a cationic polymer, a polymer of 2-methylpropenyl oxyethylphosphocholine such as polyquaternium-51, and a butyl methacrylate copolymer. Copolymer, acrylic resin emulsion, polyacrylic acid ethyl emulsion, polyalkyl acrylate emulsion, polyvinyl acetate resin Polymer emulsions such as emulsions, natural rubber latexes, synthetic latexes, nitrocellulose, polyurethanes, and various copolymers, various polyfluorenes, acrylic acid-polyoxyl graft copolymers, etc. It is a mixture of various copolymers, various fluorine-based polymers, 12-hydroxystearic acid and its salts, palmitic acid dextrin, myristic acid dextrin, glyceryl hydroxystearate, anhydrous citric acid, Asphalt cerium oxide (ultrafine hydrated ceric acid), magnesium aluminum silicate, sodium magnesium citrate, metal soap, metal dialkyl phosphate, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, Fruit oligosaccharide fatty acid ester, medlar seed extract, hydroxyethyl guar, carboxymethyl guar, starch, carboxymethyl chitin, etc., natural high molecular substances, semi-synthetic high molecular substances or high synthesis Molecular substance.

(vitamin class)

In the case of vitamins, vitamin A and its derivatives such as retinol, retinyl acetate, retinyl palmitate, thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate can be exemplified. , pyridoxine hydrochloride, pyridoxine dicaprylate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid decylamine. Nicotinic acid such as nicotinic acid benzyl, choline, vitamin B6 hydrochloride, vitamin B6 tri-palmitate, vitamin B6 dioctanoate, vitamin B12, vitamin B2, vitamin B6, vitamin B15 and Vitamins such as derivatives, such as derivatives, α-tocopherol, β-tocopherol, γ-tocopherol, nicotinic acid tocopherol, tocopherol acetate, linoleic acid tocopherol, ferulic acid tocopherol, tocopheryl phosphate Tocopherol derivatives such as esters, double bond regenerators, vitamin E acetate, succinic acid Vitamins such as tocopherols such as vitamin E, vitamin D, vitamin H, pantothenic acid, panthenol, vitamin F, vitamin K, vitamin P, etc., vitamin U, ferulic acid, γ-meter Sterol, α-lipoic acid, orotic acid, coenzyme Q10, biotin, and the like.

(amino acid)

As the amino acid, valeric acid, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, and the like can be exemplified. Aspartic acid, glutamine valine, serine, cysteine, cystine, tyrosine, valine, hydroxyproline, aspartic acid, glutamic acid, hydroxyl Amine acid, arginine, ornithine, histidine, taurine, carnitine, etc., or such sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids and such Derivatives, etc.

(anti-wrinkle agent)

Examples of the anti-wrinkle agent include glycerin, vitamin A or a derivative thereof, glycolic acid, thiolated glucosamine, actin, vitamin E or a derivative thereof, aloe extract, collagen, hyaluronic acid, tripeptide, Pyridinoids such as tetrapeptide, seaweed extract, horse chestnut extract, rosemary extract, cornflower extract, and the like.

(seaweed extract)

In the case of seaweed extract, there are extracts derived from brown algae, red algae, green algae, cyanobacteria, and the like, and specifically, it can be exemplified from kelp, real kelp, and skirt. Extracts of vegetables, sarcophagus, broccoli, coral algae, palm-shaped algae, carrageen, seaweed, sarcophagus, sarcophagus, algae, staghorn, seaweed, Okinawa, and seaweed . An extract from an aqueous plant such as Glycyrrhiza is also included.

(cell activator)

In terms of the cell activating agent, an extract of plants such as whey, rabbit, scutellaria, green algae, sedge, and leeks, and amino acids such as γ-amino-butyric acid and ε-aminohexanoic acid can be exemplified. Vitamins such as flavonol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acid, etc., α-hydroxy acids, flavonoids, saponins, allantoin, photoreceptor No. 101, such as glycolic acid and lactic acid. Photoreceptor No. 301, No. 401, NK-4, and the like.

(percutaneous absorption enhancer)

Examples of the percutaneous absorption enhancer include α-hydroxy acid such as urea, lactic acid, fruit acid, and glycolic acid, β-hydroxy acid such as salicylic acid, oleic acid, undecanoic acid, octanol, decyl alcohol, and mint. Alcohol, thymol, limonene, dimethyl hydrazine, dodecylmethyl hydrazine, dimethyl acetamide, N, N-dimethylformamide, sodium lauryl sulfate, N, N-double ( 2-hydroxyethyl)oleylamine, polyoxyethylene (20) sorbitan monooleate, dodecyldimethylammoniopropanesulfonic acid, propylene glycol, polyethylene glycol, n, n-dimethyl- M-toluidine, diethyl-m-toluidine, azone, 1-dodecyl azepan-2-one, isopropyl myristate, isopropyl palmitic acid, N -mono or disubstituted-p-methane-3-carboxydecylamine, 2-(2-methoxy-1-methylethyl)-5-methylcyclohexane An alcohol, an azacycloalkane derivative, a cyclodextrin or the like.

(foaming agent)

Foaming aspects, illustrated azobis 2carboxamide, barium azodicarboxylate ester morpholine, azobisisobutyronitrile, azobis morpholine carboxylic acid acyl amine, N, N '- dinitro pentamethylene and Methyltetramine, N,N ' -dimethyl-N,N ' -dinitro-p-amine, trinitrotrimethyltriamine, 4,4 ' -oxybis(phenylthioindole) ), p-toluene sulfonium, diphenyl sulfonium-3,3 ' -dithiopurine, allyl bis(thioindole), p-stilbene sulfonylaminocarbamidine, 4,4 ' a fluorinated alkane such as oxybis(phenylsulfonylaminocarbazide), trichloromonofluoromethane or dichloromonofluoromethane, 5-morpholinyl-1,2,3,4-thiatriazole, Ammonium carbonate, ammonium hydrogencarbonate, sodium hydrogencarbonate, ammonium nitrite, sodium borohydride, azide, and the like.

(plasticizer)

Examples of the solubilizing agent include ethanol, phenoxyethanol, isopropanol, butyl alcohol, benzyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cetearyl alcohol, and stearyl alcohol. Oleohydrin, behenyl alcohol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, glyceryl monostearate, isovaler Glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 1,2-pentanediol, 1, 5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, sorbitol, maltitol, raffinose, hexanediol, lauric acid diethanolamine, fatty acid diethanol hydrazine Polyols such as amines, polyoxyethylene alkylphenyl ethers, polyoxyethylene alkyl ethers, polyoxyethylene sterol ethers, polyoxyethylenes Cationic surfactants such as fatty alcohol esters, polyoxyethylene hardened castor seed oil, polyol fatty acid esters, ethylene glycol fatty acid esters, polyglycerin fatty acid esters, sucrose fatty acid esters, tetraalkylammonium salts, etc. , alkyl trimethyl ammonium salt, alkyl pyridinium chloride, stearin trimethyl ammonium chloride, fatty acid salt, alkyl sulfate, alkyl ether sulfate, alkyl triethanolamine, polyoxyethylene An anionic surfactant such as sodium lauryl sulfate, sodium lauryl sulfate, sodium lauryl glutamate, a betaine type such as lauryl dimethylaminoacetic acid betaine, a sulfobetaine type, or a sulfonic acid group Amphoteric surfactants such as amino acid type, polyether modified polyfluorene oxide, amine modified polyfluorene oxide, etc., lecithin, lysophosphatidylcholine, ceramide, brain A natural surfactant such as a lipid or a subtilisin sodium.

(keratinolytic agent)

Examples of the keratinolytic agent include glycolic acid, tartaric acid, salicylic acid, citric acid, lactic acid, pyruvic acid, gluconic acid, glucuronic acid, malic acid, oxalic acid, malonic acid, succinic acid, acetic acid, phenol, and isophthalic acid. Diphenol, retinoic acid, adapalene, trichloroacetic acid, 5-fluorouracil, sebacic acid, etc. Further, in the case of hormones, estradiol, estrone, ethylene estradiol, corticosterone, Cortisol, dehydrocortisol, cholecalciferol, eosin, pregnenolone, collateral cortex hormone.

(pigment)

In terms of pigments, body pigments such as talc, kaolin, mica, sericite, calcium carbonate, magnesium carbonate, magnesium citrate, anhydrous citric acid, and the like can be exemplified. White pigments such as titanium, zinc oxide, yellow iron oxide, red iron oxide, black iron oxide, ultramarine blue, iron blue, chromium oxide, chromium hydroxide, carbon black, etc., pigmented foil, oxychloride, mica titanium , pearl pigments such as pigmented mica titanium, magnesium, calcium and aluminum salts of stearic acid, zinc salts of lauric acid, palmitic acid, myristic acid, starch powder, silk powder, nylon powder, polymethyl methacrylate Powder pigments such as powders and polyethylene powders. Further, examples of the plasticizer include dibutyl phthalate, dioctyl phthalate, butyl tributyl citrate, camphor, and the like.

(inorganic powder)

Examples of the inorganic powder include calcium hydrogen phosphate, organically modified montmorillonite, citric acid, anhydrous citric acid, magnesium citrate, mica, bentonite, titanium-coated mica, oxylanthanum chloride, zirconium oxide, magnesium oxide, and oxidation. Zinc, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, indigo, chromium oxide, smithsonite, zeolite and carbon black. Further, examples of the organic powder include polyamine, polyester, polyethylene, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluororesin, oxime resin, and acrylic resin. , melamine resin, epoxy resin, polycarbonate resin, divinylbenzene. A styrene copolymer, a copolymer of two or more kinds of monomers of the above compounds, cellulose, or the like.

(other ingredients)

The skin external composition of the present invention, or in a lotion, a face lotion, a beauty lotion, an emulsion or a cream, in addition to the above, may further For anti-biomass, sugar transfer glycyrrhizin, glycyrrhizin, alpine rose azalea extract, gold saffron extract, alfalfa seed extract, pomegranate flower extract, moon peach seed extract, trumpet mushroom fruit extract, and magnolia Extract, Chlorella extract, Berryberry extract, Vibrio alginolyticus fermentation broth, human oligopeptide, Aureobasidium culture, sputum/chestnut fermented extract, Amonium Fermented serum, hydrolyzed yeast extract, yeast extract, yeast polysaccharide, rice fermentation broth, highly thermophilic Thermus thermophilus culture, wine cellar extract, yeast/Ca culture, yeast/K culture /Mg culture, yeast/zinc culture, yeast/sea salt culture, (yeast/xyloacetic acid)/black tea culture, yeast/sputum culture, yeast/sputum culture, brewer's yeast extract Yeast/Selenium Culture, Yeast/Iron Culture, Yeast/Copper Culture, Yeast Culture Solute, Yeast/Manganese Culture, Yeast Solute Extract, Pseudomonas Alternaria Fermentation Essence Liquid, bacteria Plant Gum, Sphingomonas Essence, Soybean Fermentation Essence, Soymilk Fermentation Liquid, Lactobacillus/California Hairy Grass Fermentation Essence, Lactobacillus/Olive Leaf Fermentation Essence, Lactobacillus/Cocoa Fruit Fermentation Liquid, Lactobacillus / Buckwheat Fermented Essence, Lactobacillus/Rice Fermented Essence, Lactobacillus/Pearl Juice Fermentation Liquid, Lactobacillus/Soybean Fermented Essence, Lactobacillus/Tomato Fermented Essence, Lactobacillus/Herb Fruit Fermented Essence, Lactobacillus / (milk / Ca / phosphorus / Mg / zinc) ferment, lactobacillus / hibiscus fermentation broth, lactobacillus / (legume seed extract / glutamic acid Na) fermentation broth, lactobacillus / grape juice fermentation broth , Lactobacillus/American Pumpkin Fruit Fermented Essence, Lactobacillus/(Ganoderma Lucidum Extract / Mushroom Extract) Fermentation Broth, Lactobacillus/Lemon Fruit Skin fermentation essence, Lactobacillus/Moss root fermentation essence, Lactobacillus culture solution, Bacillus/(rice bran extract/soybean essence) fermentation broth, Bacillus fermentate, Bifidobacterium fermentation essence, Sclerotium Dissolving solution, yoghurt solution, Lar's bacteria/soybean protein fermented product, red wine essence, to link β-D-glucuronic acid, α-L-iduronic acid, β-D-glucuronic acid The 3 sugar structure is composed of the acidic polysaccharides associated with the basic unit, and the gelatin-like substance derived from 鳖蕈, sunflower bud extract, jackfruit extract, longan extract, Indian golden button extract, sea bream Fruit extract, goat's beetle extract, geranium extract, actin, glycosidic acid, ethylhexyl glycerol, ethoxydiglycol, oleyl glyceryl, gluconolactone, two Octyl ether, dihydroxyacetone, panthenol ethyl ether, hydroxyalkyl (C16-18) hydroxydimerized dilinyl ether, hydroxyalkyl (C12-14) hydroxydimeric dilinyl ether, methoxy Ether and ketones such as ethanol, asiatic acid, oleic acid, sodium ursate , oleanolic acid, hydrazine hydrochloride, aluminum citrate, sodium citrate, diammonium citrate, tris(tetramethylhydroxypiperidinol) citrate, sodium amber glucosinolate, dithioglycolic acid , dithioglycolic acid MEA, diammonium dithiodiglycolate, sebacic acid, thioglycolic acid, thioglycolic acid MEA, ammonium thioglycolate, thiolactic acid, thiolactic acid Organic acid or salt thereof of ammonium, panthenary sulfonate, calcium propionate, sodium propionate, platonic acid, sodium succinate, hydroxysalicylic acid, etc., aminomethylpropanol, aminomethylpropane Amines such as diol, diisopropanolamine, cysteamine hydrochloride, tetrahydroxypropylethylenediamine, deoxyribonucleic acid (DNA), deoxyribonucleic acid potassium salt, ribonucleic acid (RNA), ribose Sodium citrate, almond protein, aspartame, adenosine phosphate, adenine Nucleoside sodium phosphate, propylamine glutamine glutamine, (arginine/lysine) polypeptide, undecylenyl phenylalanine, ergothiol, oligopeptide-6 , ornidamine hydrochloride, hydrolyzed DNA, hydrolyzed RNA, hydrolyzed almond protein, hydrolyzed actin, hydrolyzed elastin, hydrolyzed casein, hydrolyzed wild oat protein, hydrolyzed keratin, hydrolyzed yeast protein, hydrolyzed rice protein, hydrolyzed shell Quality, hydrolyzed silk, hydrolyzed white flower lupin protein, hydrolyzed soy protein, hydrolyzed zein, hydrolyzed milk protein, hydrolyzed honey protein, hydrolyzed prion protein, hydrolyzed jojoba protein, hydrolyzed wild vegetable protein, hydrolyzed royal jelly protein, wild oat grain Protein, bovine lactoprotein, guanine nucleotide 2 sodium, creatine, keratin, wheat gluten, wheat protein, creatinine, citrulline, dipalmitosyl hydroxyproline, dipeptide-2 , protein of serine, soy protein, hexapeptide-2, hexapeptide-3, hexapeptide-9, hexapeptide-10, hexapeptide-11, pentapeptide-3, serum protein, etc. And nucleic acids, coenzyme A, subtilisin, papain, proteolytic enzymes, phoenix Enzymes such as enzymes, lipolytic enzymes, α-glucosidase, terpenes such as menthone glycerol acetal, (C30-38 olefin/maleic acid isopropyl/maleic acid) copolymer, (HDI/ PPG/polycaprolactone) interactive polymer, PEG-4, PEG-6, PEG-8, PEG-12, PEG-16, PEG-20, PEG-30, PEG-32, PEG-40, etc. A propylene oxide polymer or a derivative thereof, a diol, a PPG-3, a PPG-7, a (VA/crotonic acid/nicotinic acid vinyl) copolymer, a (VP/acrylic acid DMAPA) copolymer, (VP/ethylene) Hexylamine/acrylic acid DMAPA) copolymer, (VP/methacrylamide/vinylimidazole) copolymer, (acrylamide/ammonium acrylate) copolymer, (acrylamide/acrylonitrile dimethyl) Sodium taurate/acrylic acid) copolymer, (acrylamide) Copolymer of propylene decyl dimethyl taurate), (sodium acrylate / sodium propylene dimethyl dimethyl sulfonate) copolymer, (sodium acrylate / acrylonitrile dimethyl taurine) copolymer, Acrylic acid / acrylamide methyl propane sulfonic acid) copolymer, (acrylic acid / alkyl acrylate (C10-30)) copolymer, (amidopropyltrimethylammonium chloride / decylamine acrylate) copolymer, ( Acrylic acid alkyl/octyl acrylamide copolymer, alkyl acrylate copolymer or derivative thereof, (alkyl acrylate/diacetone acrylamide/amine-terminated dimethyl polyoxyalkylene) copolymer AMP, (Alkyl acrylate/diacetone acrylamide) copolymer, (alkyl acrylate/diacetone acrylamide) copolymer AMP, (alkyl acrylate/diacetone acrylamide) copolymer AMPD, (hydroxyethyl acrylate/ a butyl acrylate/methoxyethyl acrylate copolymer, a (hydroxyethyl acrylate/methoxyethyl acrylate) copolymer, a (hydroxyethyl acrylate/sodium decyldimethyltaurate) copolymer, (Acrylate / acrylamide) copolymer, (acrylate / alkyl acrylate (C10-30)) interactive polymer, (acrylate / alkyl acrylate Stearic acid/ethyl methacrylate oxide copolymer, (acrylate/hydroxyalkyl acrylate) copolymer, acrylate copolymer, carboxyvinyl polymer, (ethylene/propylene) copolymer, (ethylene/propylene) /styrene) copolymer, (octyl acrylamide / hydroxypropyl acrylate / butylaminoethyl methacrylate) copolymer, synthetic wax, hydrogenated C16-14 olefin polymer, (butene / ethylene / benzene Ethylene) copolymer, polyacrylamide, sodium polyacrylate, polyethylene isophthalate, Polyoctanium-5, Polyoctanium-6, Polyoctanium-7, Polyoctanium-11, Polyoctanium-16, Polyoctanium-22, Polyoctanium-28, Polyoctanium-32, etc. Polyoctanium, polyglucuronic acid, polydecene, polypropyl sesquiterpene oxide, polyglyceryl methacrylate, polymethacryl decyl ethyl betaine, polymethacryl decyl ethyl betaine, Synthetic polymer compound such as rapamycin, acetamidine dipeptide-1 cetyl group, acetamidine tetrapeptide-2, acetamidine tetrapeptide-5, acetamidine hexapeptide-1, acesulfame-6 Peptide-3, isoalkyl (C8-16) sodium succinate globulin sulfonate, which is generally equivalent to a skin-derived composition for cosmetics, and may be further used, in addition to the above-mentioned existing cosmetics raw material. For example, the "Second Edition of Cosmetics Raw Materials Standards", the Japan Public Book Association, the Pharmaceutical Affairs Daily, and the 1984 issue; the "Specifications for Cosmetic Raw Materials Standards" and the Supervisory Board of the Ministry of Health and Welfare, Pharmacy Daily News Co., Ltd., issued in 1993; "Reparation of ingredients for reference of cosmetic raw materials", supervision of the Ministry of Health and Welfare Bureau, Pharmacy Daily, and company in 1993; "Specifications for Cosmetic Substances", review by the Ministry of Health and Welfare Class supervision, Pharmacy Daily, the company, issued in 1993; "Specifications for the synthesis of cosmetic substances", the supervision of the Ministry of Health and Welfare, the Pharmacy Daily, and the company issued in 1997; "The Latest Cosmetic Science - Revision II", Japanese Cosmetics Technician, Pharmacy Daily, Joint Stock Company, Heisei 4, and Cosmetics Code, Japan Cosmetics Technician, Maruzen Co., Ltd., 2003, Japan Cosmetics Materials Collection 2007, Japan Cosmetics Industry Co., Ltd. All the makeup recorded in the editorial, the company's Pharmaceutical Daily, and the 2007 issue. Raw materials.

C. Manufacturing method

The skin external composition of the present invention, or a base cosmetic containing the lotion, the facial cleanser, the cosmetic liquid, the lotion, or the cream, is mixed with L-ascorbic acid as an active ingredient in an aqueous medium as a base. And one or more of the steps selected from the derivatives and the salts thereof. More specifically, one or two or more selected from L-ascorbic acid, a derivative thereof, and the like are mixed as an active ingredient in an aqueous medium as a base, and the pH of the solution is made After 3 to 11, more preferably 5 to 9, the appropriate prescription for the type of product to be used may be included in an appropriate step until the completion of the intended product. The mixing method, the sequence, and the various stages of the respective components are not particularly limited, and the appropriate methods and procedures generally used in the field may be employed without impairing the effects of the present invention.

In particular, when manufacturing a skin external composition of the present invention using hydrated or anhydrous crystals of ascorbic acid 2-glucoside-sodium salt, or a base cosmetic such as a lotion, a face lotion, a beauty lotion, an emulsion, or a cream, By blending ascorbic acid 2-glucoside-sodium salt crystals with ascorbic acid 2-glucoside anhydrous crystals in advance at a suitable blending ratio to form a composition, it is possible to additionally perform the anhydrous crystallization of ascorbic acid 2-glucoside as in the past. In the case of neutralizing with a base, the pH at the time of dissolving in an aqueous medium is adjusted to a desired 3-11, preferably 5-9. According to this production method, it is not only necessary to carry out the step of neutralizing the alkali separately, but also it is preferable to reduce the salt concentration due to the addition of the alkali or the buffer.

In the above-mentioned skin external composition of the present invention, or a base cosmetic such as a lotion, a facial cleanser, a cosmetic liquid, an emulsion or a cream, The blending amount of one or two or more selected from the group consisting of L-ascorbic acid, a derivative thereof, and the like is not particularly limited, and may be appropriately determined depending on the purpose, but usually the product mass per unit is solid. In terms of L-ascorbic acid, the content of L-ascorbic acid is 0.1% by mass to 90% by mass, preferably 0.5% by mass to 50% by mass, more preferably 1% by mass to 10% by mass, even more preferably 5 ~10% by mass is good.

The skin external composition of the present invention, or a base cosmetic such as a lotion, a facial cleanser, a cosmetic liquid, an emulsion or a cream, which is produced as described above, contains 1 selected from L-ascorbic acid, a derivative thereof and the like. As an active ingredient, it is excellent as an anti-aging effect, such as anti-wrinkle, anti-fine-grain, anti-plaque, and anti-relaxation.

Hereinafter, the present invention will be described in further detail based on experiments.

<Experiment 1: Effect of ascorbic acid 2-glucoside on conversion in the skin>

As described in the present specification, the epidermis is composed of "the stratum corneum (corner layer)", "granular layer", "spine layer", and "basal layer" from the outer layer, and the epidermal cells born in the basal layer are sequentially directed. The outer side moves to become the stratum corneum and finally peels off. Such a cycle is generally called a conversion. If the transition is stagnant due to age, it will cause skin troubles such as loose skin, wrinkles, and fine lines. In order to investigate the effect of ascorbic acid 2-glucoside on conversion, the following experiment was carried out.

<Experiment 1-1: Effect of ascorbic acid 2-glucoside on skin cell proliferation>

Normal human neonatal foreskin epidermal keratinocytes (sold as "NHEK cells", hereinafter referred to as "NHEK cells") are suspended in the cell proliferation additive (EDGS: EpiLife Defined Growth Supplement) containing EpiLife medium (Invitrogen, which will contain EDGS) The EpiLife medium is abbreviated as "EpiLife medium", and subcultured in the presence of 5 vol% CO ₂ at 37 ° C with 60-80% confluence. After the cells were removed and washed, they were adjusted to 7.5 × 10 ³ cells/mL with HuMedia-KB2 medium (sold by Kurabo Industries), and then encoded with collagen (sold by Shinta Gelatin, trade name "Cellmatorix Type IV"). The 24-well plate was inoculated at 0.4 mL/acupoint, and cultured for 1 day in the presence of 5 vol% CO ₂ at 37 °C. After the culture supernatant was removed, a powder containing anhydrous crystals of ascorbic acid 2-glucoside was dissolved in HuMedia-KB2 medium (should be sold as "KB2-HI medium"), which was added with cortisol and insulin (hereinafter referred to as "KB2-HI medium"). The product name "AA2G" and Linyuan Co., Ltd. are sold. The final concentration of ascorbic acid 2-glucoside is 0-900 μM, which is added one by one at 0.6 mL/acupoint, and cultured at 37 °C for 4 days in the presence of 5 vol% CO ₂ . . After fixing the cells with a 25% glutaraldehyde solution by adding 60 μL/acupoints one by one, the supernatant was removed, washed with water, and then a methylene blue solution was added at 0.24 mL/acupoint for nuclear staining. After washing with water, 0.33 N hydrochloric acid was added one by one at 0.5 mL/acupoint to extract the pigment, and the solution was removed one by one at 0.1 mL/acupoint in a 96-well plate, and the absorbance at a wavelength of 595 nm and 650 nm was measured. The value obtained by subtracting the absorbance value of the wavelength of 650 nm from the absorbance value of the wavelength of 595 nm was used as an index of the cell proliferation rate. The cell proliferation rate was relatively evaluated by using the KB2-HI medium containing no ascorbic acid 2-glucoside as a control, and the value at this time was taken as 100%. The results are shown in Table 1.

As seen in Table 1, ascorbic acid 2-glucoside showed a strong proliferation-promoting effect on NHEK cells, and its relative cell proliferation rate was 148% at 100 μM, 157% at 300 μM, and 169% at 900 μM. The concentration of ascorbic acid 2-glucoside increased and increased. The above results indicate that the proliferation of skin epidermal cells is promoted by ascorbic acid 2-glucoside, which can improve the conversion in the skin and reduce the occurrence of wrinkles, fine lines or slack. In addition, ascorbic acid 2-glucoside will cause L-ascorbic acid to be freed by the enzyme present in the experimental NHEK cells, and the above effect can also be said to be the action of L-ascorbic acid. In addition, the same was true in the following experiment 1-2.

<Experiment 1-2: Effect of ascorbic acid 2-glucoside on the expression of protein of differentiation index of skin cells>

In recent years, in terms of differentiation index proteins of epidermal cells, coating proteins and silk polyproteins have attracted attention. This experiment is to investigate the effect of ascorbic acid 2-glucoside on the expression of differentiation index proteins.

Normal human neonatal foreskin epidermal keratinocytes (NHEK cells) were prepared into 2.5×10 ⁵ cells/mL with EpiLife medium, and then inoculated one by one at 1 mL/acupoint in a 12-well plate, in the presence of 5 vol% CO ₂ at 37 ° C. The culture was carried out for 1 day under the conditions. After the culture supernatant was removed, a medium having a final concentration of ascorbic acid 2-glucoside of 300 and 600 μM was injected into 1 mL/acupoint, and cultured at 37 ° C for 2 days in the presence of 5 vol% CO ₂ . Further, a culture medium containing no ascorbic acid 2-glucoside was used in the same manner as a control. The medium prepared by adding the same concentration of ascorbic acid 2-glucoside-sodium salt was additionally injected at 1 mL/acupoint, and cultured for 3 days under the same conditions. After removing the culture supernatant, the cells were washed with phosphate buffered saline (PBS), and then used as a cell extraction buffer (proteolytic enzyme inhibitor, 2% SDS, 20 mM Tris-HCl buffer containing 1 mM EDTA, pH 8.0). The cells were lysed, and after reacting for 20 minutes on ice, proteins were extracted by ultrasonication using a Sonifier (manufactured by Branson Co., Ltd.). The extract was centrifuged, the supernatant was recovered, and a part of it was subjected to protein quantification. Mix 3-4 times the concentrated supernatant buffer (50 mM dithiothreitol, 40% glycerol, 250 mM Tris-HCl buffer containing 0.02% bromophenol blue, pH 6.8) in the remaining supernatant. It was kept at 99 ° C for 5 minutes, and it was used as a sample for Western ink dot analysis. The protein was injected at a concentration of 20 μg in one column, and after the SDS-polyacrylamide colloidal electrophoresis was carried out by a usual method, the protein in the colloid was transferred to a polydivinylidene oxide (PVDF) film by a usual method, and immersed in Block Ace. It is sealed in (DS Drug Biomedical Company). The PVDF membrane was diluted 100-fold anti-coating protein antibody or anti-drug with 50 mM TBS (50 mM Tris-HCl (pH 7.4) containing 200 mM NaCl) buffer (hereinafter referred to as "TBS buffer") containing 10% by volume of Block Ace. The solution prepared by the filaggrin antibody (sold by Santa Cruz) was immersed for 1 hour at room temperature, and then washed with 50 mM TBS buffer containing 0.05% by volume of TWEEN20 to remove excess antibody. The PVDF membrane was immersed in a solution of HRP-labeled anti-mouse IgG rabbit polyclonal antibody (DAKO) for 2 hours at room temperature. The membrane was washed with 50 mM TBS buffer containing 0.05% by volume of TWEEN 20 for 30 minutes, and then sold using a commercially available Western blot method (GE HELTHCARE BIOSCIENCES, sold under the trade name "ECL Prime Western Blotting Detection System"). Check out and perform image analysis using image analysis software ("ImageJ", NIH development open source software). Using α-tubulin as an internal standard, the performance of each protein was corrected to the relative amount of expression of α-tubulin (50% of the control), and the amount of expression was compared. The results are shown in Table 2.

As shown in Table 2, depending on the concentration of ascorbic acid 2-glucoside, both the coating protein and the silk fibroin as the differentiation index protein were enhanced. The above results show that the differentiation of skin epidermal cells is promoted by the action of ascorbic acid 2-glucoside, and the cosmetic containing ascorbic acid 2-glucoside is excellent in the effect of improving the conversion in the skin.

<Experiment 2: Anti-plaque effect of ascorbic acid 2-glucoside>

For the female subject, 16 (aged 37 to 55 years old), the pigmented deposit attachment site (plaque site) produced on the face of the face was used as the test site, and the following blended cream containing ascorbic acid 2-glucoside was applied. 2 times a day (early and late), 1 time 2g, smeared 90 days. Before the application of the cream, on the 45th and 90th day of the application, PANTONE FORMULA GUIDE747XR was used to investigate the color of the examined part of each subject, and the brightness of the tested part was measured by a colorimeter CR-200 (manufactured by MINOLTA). (L ^* value), the average value of 16 people was calculated. The results are shown in Table 3.

<The blending composition of the test cream> <A phase>

<B phase>

<C phase>

Triethanolamine 99%

<D phase>

Powder containing ascorbic acid 2-glucoside anhydrous crystal 2.0

(trade name "AA2G", Linyuan Co., Ltd.)

<E phase>

Propylene glycol 56%, urea aldehyde 30%, methyl paraben 11%, propyl paraben 3% 1.0

The components of the phase A were heated while being mixed, and the components of the phase B were heated in the same manner and mixed, and then the phase B was added to the phase A. After the phase C was added thereto, it was cooled, and after the phase D and the phase E were added, the mixture was adjusted to pH 6.5 with triethanolamine.

As shown in Table 3, depending on the number of days of application, the L ^* value (lightness) of the site to be inspected increases, and the color of the pigmentation attachment site becomes thinner. In general, the plaque is different from the sunburn and does not disappear with time. Therefore, as a result of the above, it is understood that the ascorbic acid 2-glucoside can lighten the pigment deposition site of the skin and exhibit an effect of improving the plaque.

<Experiment 3: Effect of ascorbic acid 2-glucoside on glutamine-based sulfur production (1)>

The glutamine-based sulphur is a peptide that acts as an acid-resistant component and a supplemental enzyme in the living body, and is usually present in an oxidized form, but its function can be converted into a reduced form by an enzyme. Therefore, it is preferable to have a high glutamine-based sulfur level in the living body, and it is known that the reduction of the glutamine-based sulfur level is one of the causes of aging. To investigate the effect of ascorbic acid 2-glucoside on the production of glutamine-based sulfur, a cell line derived from human epithelial cell carcinoma (A431 cells, HS Research Resources Bank, JCRB0004) (hereinafter abbreviated as "A431 cells") was used. And it is implemented as follows.

<test solution>

In the MEM medium (hereinafter abbreviated as "D-MEM medium") containing 10% (v/v) bovine fetal serum and anti-biomass Dulbecco, ascorbic acid 2-glucoside (Linyuan stock sales, reagent level) and L-ascorbic acid (sold by Wako Pure Chemical Industries, Ltd., special grade) was dissolved, and the test liquid was prepared so that the final concentration of ascorbic acid 2-glucoside or L-ascorbic acid became 1.0 or 2.0 mM.

<Quantification method of glutamine-based sulfur production amount in A431 cells>

The D-MEM medium was used to recover the subcultured A431 cells, and then suspended in D-MEM medium, and cultured in a flat plate of 10 cm diameter cells, sown at 1 × 10 ⁶ cells / 10 ml / flat plate, and cultured for 24 hours. . Thereafter, the culture solution was removed by suction, and any of the test solutions was added at 10 ml/plate and cultured for 24 hours. On the control side, only D-MEM medium was added at 10 ml/plate and cultured for 24 hours. In each of the flat plates from which the culture supernatant had been removed, the ice-cold Dulbecco PBS (-) (sold by Risho Pharmaceutical Co., Ltd.) was injected, and after the cells were washed, the cells were recovered using a doctor blade. The measurement was carried out using a commercially available glutamine-based sulfur measuring kit (available from Bio vision, trade name "Gluthatione Assay Kit"). Each of the experiments was carried out using a control plate or a test solution using three flat plates, and the average amount of glutamine sulfur in each flat unit was determined as the amount of glutamine-based sulfur produced. Further, the culture of A431 cells was carried out in any case using a 5 volume% carbonic acid gas culture apparatus. The amount of reduced form or total glutamine sulfur produced by A431 cells cultured only in D-MEM medium was taken as 100% to obtain relative values, and the results are shown in Table 4.

As shown in Table 4, D-MEM medium supplemented with 1.0 mM of L-ascorbic acid produced a cell disorder, and reduced glutamine sulfur and total glutamine sulfur in A431 cells could not be measured. In addition, when L-ascorbic acid having an upper limit of concentration of 0.1 mM which does not cause a cell disorder under the above conditions is added, the total glutamine-based sulfur and reduced-type glutamine-based sulfur produced by A431 cells are 103% and 102%, respectively. The same degree as in the case of no addition, the increase in the amount of glutamine-based sulfur caused by L-ascorbic acid could not be confirmed.

On the other hand, when A431 cells were cultured in a medium containing 1.0 mM or 2.0 mM of ascorbic acid 2-glucoside in D-MEM medium, no cell disorder was caused, and total glutamine sulfur production was increased, and each was 115%, 508%, and is believed to increase the total glutamine sulfur production depending on the amount of addition of ascorbic acid 2-glucoside. Further, the amount of reduced glutamine-based sulfur produced was 313% and 6816%, respectively, and the increase in the production of reduced-type glutamine-based sulfur was confirmed depending on the amount of addition of ascorbic acid 2-glucoside. In addition, the reduction of reduced glutamine-based sulfur is greater with respect to the increase in total glutamine-based sulfur, which in particular shows an increase in the reduced glutamine-based sulfur level. In the case of A431 cells, it is considered that L-ascorbic acid can be released from ascorbic acid 2-glucoside to the extent that it does not cause cytotoxicity, thereby exerting an effect of enhancing the production of glutamine-based sulfur.

<Experiment 4: Effect of ascorbic acid 2-glucoside on glutamine-based sulfur production (2)>

The experiment of investigating the effect of ascorbic acid 2-glucoside on glutamate-based sulfur was carried out using normal human neonatal epidermal keratinocytes (NHEK cells, Kurabo Industries) (hereinafter abbreviated as "NHEK cells"), and was carried out as follows.

<test solution>

In the EpiLife medium used in Experiment 1-1, dissolved ascorbic acid 2-glucoside (Linyuan stock sales, reagent grade) and L-ascorbic acid (Wako Pure Chemical Industries Co., Ltd., special grade) to make ascorbic acid 2-glucoside or The final concentration of L-ascorbic acid is 0.5, 1.0, 2.0 mM, adjusted Test solution.

<Quantification method of glutamine-based sulfur production amount in NHEK cells>

The subcultured NHEK cells were recovered using EpiLife medium, suspended in EpiLife medium, and seeded in a 10 cm diameter cell culture plate at 1 × 10 ⁶ cells / 10 ml / plate for 24 hours. Thereafter, the culture solution was removed by suction, and any of the test solutions was added at 10 ml/plate and cultured for 24 hours. On the control side, only EpiLife medium was added at 10 ml/plate and cultured for 24 hours. In each of the flat plates from which the culture supernatant had been removed, the ice-cold Dulbecco PBS (-) (sold by Risho Pharmaceutical Co., Ltd.) was injected, and after the cells were washed, the cells were recovered using a doctor blade. The measurement was carried out using a commercially available glutamine-based sulfur measuring kit (available from Bio vision, trade name "Gluthatione Assay Kit"). For each of the experiments, the control or test solution was carried out using 3 flat plates, and the amount of glutamine sulfur in each flat unit and the average amount thereof were determined as the amount of glutamine-based sulfur. Further, the culture of NHEK cells was carried out in any case using a 5 volume% carbonic acid gas culture apparatus. The relative reduction values of the reduced or total glutamine sulfur of NHEK cells when cultured only in EpiLife medium were 100%, and the results are shown in Table 5.

As shown in Table 5, EpiLife medium supplemented with 0.5 mM L-ascorbic acid produced a cell disorder, and reduced glutamine sulfur and total glutamine sulfur in NHEK cells could not be measured. In addition, when L-ascorbic acid having an upper limit of concentration of 0.1 mM which does not cause cell disorder under the above conditions is added, the total glutamine-based sulfur and reduced-type glutamine-based sulfur produced by NHEK cells are 103% and 102%, respectively. The same degree as in the case of no addition, the increase in the amount of glutamine-based sulfur due to L-ascorbic acid could not be confirmed.

In contrast, when NHEK cells were cultured in a medium supplemented with ascorbic acid 2-glucoside 0.5, 1.0 mM or 2.0 mM in EpiLife medium, the total glutamine-based sulfur production was 106%, 111%, and 117%, respectively. It is also believed that the total glutamine-based sulfur is enhanced depending on the amount of addition of ascorbic acid 2-glucoside. Further, when NHEK cells were cultured in a medium supplemented with ascorbic acid 2-glucoside 0.5, 1.0 mM or 2.0 mM in EpiLife medium, the amount of reduced glutamine-based sulfur was 106%, 111%, and 117%, respectively. It is considered that the reduced amount of reduced glutamine-based sulfur is enhanced depending on the amount of addition of ascorbic acid 2-glucoside. Further, the degree of increase of the reduced glutamine-based sulfur is the same as that of the total glutamine-based sulfur, which means that the total glutamine-based sulfur is increased in the case where the reduced-type glutamine-based sulfur level is not lowered. As in the case of A431 cells of Experiment 3, even in the case of NHEK cells, it is considered that L-ascorbic acid can be freed from ascorbic acid 2-glucoside without causing cytotoxicity, and glutamate-based sulfur is produced. Enhancement.

The results of experiments 3 and 4 show that ascorbic acid 2-glucoside has enhanced total glutamine sulfur production and enhanced reduced glutathion sulfur production. A significant effect of the ascorbic acid 2-glucoside system can be utilized as a total glutamine-based sulfur production enhancer or a reduced-type glutamine-based sulfur production enhancer, and it is taught that by this action, the living body can be inhibited. Ageing.

<Experiment 5: Effect of ascorbic acid 2-glucoside on Dickkopf-1 production>

A protein which is present in human skin, which is a Dickkopf-1 (hereinafter abbreviated as "DKK1") which inhibits the formation and accumulation of melanin which causes plaque formation, is investigated, and the influence of ascorbic acid 2-glucoside on DKK1 is investigated. In the experiment, normal human skin fibroblast NHDF cells (sold by Kurabo Industries, Inc.) having DKK1 production ability were used, and were carried out as follows.

<Effects of ascorbic acid 2-glucoside on the production of DKK1 in NHDF cells>

NHDF cells were seeded in a 96-well plate by diluting the culture medium to a cell concentration of 1 × 10 ⁴ cells/well. After 24 hours of sowing, the supernatant in each well of the flat plate was removed, and ascorbic acid 2-glucoside was added to each acupoint to have a final concentration of 0.5, 1, 2, 4 or 8 mM. In contrast, the design did not add a series of ascorbic acid 2-glucoside. After the addition of ascorbic acid 2-glucoside, the supernatant of each acupoint of the 96-well plate was taken on the first day and the third day of the culture, and the supernatant was quantified by ELISA (trade name "RayBio", RayBiotech) using DKK1 measurement. DKK1 (n=3). The statistical analysis of the measured values was carried out by t-test (refer to "Statistics of Basic Statistics III Natural Science", issued by the University of Tokyo Press Conference, 187 pages (2008)). The results are shown in Table 6.

As shown in Table 6, the ascorbic acid 2-glucoside is proportional to the concentration, intentionally promoting the production of DKK1 from NHDF cells, and also from the relationship between the amount of DKK1 produced on the first day and the third day of the culture day, The culture time was positively associated with the intentional promotion of DKK1 production.

From the results of this experiment, it is known that ascorbic acid 2-glucoside promotes the production of DKK1 by administration to a living body, thereby suppressing the melanin production of melanocytes, inhibiting the delivery of melanin to keratinocytes, and exerting anti-plaque, Whitening effect. It can be said that ascorbic acid 2-glucoside is hydrolyzed into L-ascorbic acid and D-glucose by the action of enzymes in the living body, thereby exerting the original function of L-ascorbic acid, so L-ascorbic acid is more than the original, ascorbic acid 2- A derivative of L-ascorbic acid other than glucoside, a salt of L-ascorbic acid, and a salt of an L-ascorbic acid derivative are also administered to a living body to promote the production of DKK1, thereby suppressing melanin production by inhibiting melanocytes. It inhibits the transport of melanin bodies to keratinocytes, and the effect of anti-plaque and whitening is effective. Especially ascorbic acid 2- The crystallization of glucoside and its sodium salt is more stable than L-ascorbic acid, and it is the function of L-ascorbic acid due to the free L-ascorbic acid in the living body. It is most suitable for promoting the production of DKK1. ingredient.

<Experiment 6: Effect of activation of small eyeball-related transcription factors involving ascorbic acid 2-glucoside>

A microphthalmia-associated transcription factor (hereinafter abbreviated as "MITF"), a protein specifically expressed in obese cells, osteoclasts, pigment cells, or cardiac cells, which can be activated by phosphorylation. It is affected by the performance of various proteins associated with melanocytes or allergic symptoms. By inhibiting the activation of MITF, it is possible to suppress allergic symptoms or abnormal proliferation of melanocytes, and it is expected to have an effect of suppressing roughness or whitening of the skin. The experiment of investigating the effect of ascorbic acid 2-glucoside on the activation of MITF was carried out using mouse melanoma cell line B16 cells (hereinafter abbreviated as "B16 cells"), and was carried out as follows.

<test solution>

In the MEM medium (hereinafter abbreviated as "D-MEM medium") containing 10% (v/v) bovine fetal serum and anti-biomass Dulbecco, ascorbic acid 2-glucoside (Linyuan stock sales, reagent level) and L-ascorbic acid (sold by Wako Pure Chemical Industries, Ltd., special grade) was dissolved, and the test liquid was prepared so that the final concentration of ascorbic acid 2-glucoside or L-ascorbic acid became 2.0 or 8.0 mM.

<Quantification method of MITF production amount in B16 cells>

The subcultured B16 cells were recovered using D-MEM medium, suspended in D-MEM medium, and cultured for 24 hours in a 6-well plate at 1 × 10 ⁵ cells / 2 ml / acupoint. Thereafter, the culture solution was removed by suction, and any one of the test solutions was added at 2 ml/acupoint for 2 hours. On the control side, only D-MEM medium was added and cultured for 2 hours at 2 ml/plate. In each flat plate from which the culture supernatant has been removed, the ice-cold Dulbecco PBS (-) (sold by Rishui Pharmaceutical Co., Ltd.) is injected, and after washing the cells, it will contain 62.5 mM Tris-HCl pH 6.8, 2% SDS. The SDS sample buffer of 10% glycerol, 50 mM dithiothreitol, and 0.01% bromophenol blue was added at 0.1 ml/acupoint, and the cells were recovered by a doctor blade. This cell liquid was treated with an ultrasonic wave breaker (Osminics), and subjected to SDS polypropylene guanamine colloid electrophoresis. After electrically transcribed on a nitrocellulose membrane, a primary antibody (Antiphosph-MITF (Ser473), or Anti MITF), a secondary antibody is reacted, and LumiGLO is reacted, and the X-ray film is exposed to detect MITF. Positive band. The intensity of the resulting bands was analyzed using Scion Image to determine the amount of phosphorylated MITF and MITF. Further, the culture of B16 cells was carried out in any case using a 5 volume% carbonic acid gas culture apparatus. When the amount of β-actin in B16 cells cultured in each test solution was taken as 100%, the relative amounts of MITF and MITF were phosphorylated, and the ratio of phosphorylated MITF/MITF was determined. The results are shown in Table 7.

As shown in Table 7, a D-MEM medium supplemented with 2.0 mM L-ascorbic acid produced a cell disorder, and the amount of MITF in B16 cells could not be measured. In addition, the phosphorylated MITF/MITF in B16 cells was 0.90 when cultured in D-MEM medium (no addition of ascorbic acid 2-glucoside).

On the other hand, in B16 cells cultured in a medium supplemented with 2.0 or 8.0 mM ascorbic acid 2-glucoside in D-MEM medium, the phosphorylated MITF/MITF ratio was 0.60 and 0.36, respectively, depending on the ascorbic acid 2-glucoside. The amount of addition was added to confirm the inhibition of phosphorylation of MITF. The results of these experiments show that ascorbic acid 2-glucoside has a significant effect of inhibiting the phosphorylation of MITF, and ascorbic acid 2-glucoside inhibits the activation by MITF phosphorylation, and teaches that it can be used to inhibit skin. Rough or whitening function.

<Experiment 7: Anti-wrinkle test of ascorbic acid 2-glucoside (1)>

In order to investigate the effect of wrinkle improvement in the skin, the test was carried out in a voluntary manner using a cream blended with ascorbic acid 2-glucoside. That is to say, 16 women aged 37-55 who are plagued by wrinkles on the face are selected as subjects, and ascorbic acid 2-glucoside is a powder containing anhydrous crystals of ascorbic acid 2-glucoside (trade name "AA2G", Linyuan public The company's blended test cream blended with 2% by mass of the powder, 1 g once, after washing in the morning and 2 times after the bath in the evening, continuously applied for 90 days around the left and right eyes. . In addition, the test cream was maintained as much as possible on the skin during the test. During the trial, the subject should try to avoid ordinary daily life in addition to guiding the use of cosmetics that flaunt the effect of wrinkle improvement. At the beginning of the test (day 0), the middle of the test (45th day), and the end of the test (90th day), the depth of the wrinkles was measured from the skin surface shape by the following method, and the average value was obtained, and the result was obtained. Shown in Table 8.

<Three-dimensional measurement of skin surface shape wrinkles>

At the beginning of the test (day 0), the middle of the test (45th day), and the end of the test (90th day), the two eye tails were used as the test site, and the replica sample for reflection was used as the set ABS-01-W. (made by ASAHI BIOMED), take a copy of the skin. The surface shape of the replicated sample was analyzed using a replica sample analysis system ASA-03R (manufactured by ASAHI BIOMED Co., Ltd.) to determine the wrinkle portion, and the average depth of wrinkles from the reference surface in the examined portion was obtained.

<Test cream> (mixing prescription)

As shown in Table 8, if a cream blended with ascorbic acid 2-glucoside was applied, the depth of wrinkles was reduced depending on the number of days of application. This result shows that ascorbic acid 2-glucoside has an effect of improving wrinkles in the skin.

<Experiment 8: Anti-wrinkle test of ascorbic acid 2-glucoside (2)>

Although it is not clearly recorded in Experiment 7, in Experiment 7, the average depth of the wrinkles of both eyes of the volunteers around the age of 40 has been confirmed to have a shallower tendency than the volunteers of other ages. In addition, 10 female volunteers of 40±2 years old were used as subjects to investigate the effect of blending ascorbic acid 2-glucoside cream. That is, the same procedure as in Experiment 7 was carried out except that the test period was 42 days, and the same cream as that of the ascorbic acid 2-glucoside used in Experiment 7 was used, and it was carried out in the same manner as in Experiment 7. The effect of the fine lines on the tail of the two eyes was tested (hereinafter referred to as "additional test"), and 6 of the 10 subjects were considered to have significant fine lines at the end of the eye, and at the same time the skin at the end of the eye. The gloss or moisturizing state is also good. In addition, in this additional test, the purpose of investigating the conversion of the skin at the end of the eye is immediately and immediately after the start of the test, and the conversion method of the horn layer caused by the corneal cell area (slide agglutination method) is used. Refer to "FRAGRANCE JOURNAL", Vol. 36, No. 5, 28~ On page 30, 2008), the adhesive tapes were respectively attached to the tails of the two eyes of the subjects, and the keratinocytes on the surface of the skin were taken. After staining and measuring the area of the cornes, the cells measured before the test were compared. The area of the horn cells of the two eyes of the subject. Further, the above-described slice conversion measurement method is a relatively simple method of estimating the skin transformation speed by measuring the cell area of the cornea (the size of the cells). In addition, the present method is based on the following relationship between the area of the corneum cell and the transformation of the horn layer: the faster the transformation of the horn layer becomes, the area of the horn cell is reduced, and the transformation of the horn layer corresponds to the formation of keratin The rate of division of the basal cells of the cells, in addition, the conversion rate of the horn layer is proportional to the skin's rate of conversion.

According to the results of the aforementioned corneal transformation measurement, the corneal cell area of the two eyes of the aforementioned subjects was reduced by about 5% on average, and the conversion speed of the horn layer of the two eye tails (basal cells) The split speed) can be increased by a factor of 1.2 on average. In the 42-day test period set in this additional test, if the age of the volunteer corresponding to the conversion of the skin is considered to be small, and the delay of the known conversion induces fine lines, the results of this test show that This cream instantly improves the skin's conversion delay and improves the appearance of fine lines. In addition, the age of 40±2 years old is the age of about 2 times of the conversion of the skin, and it is the age at which the fine lines appear. Therefore, the cream is used as the so-called old age generation including the age group. It is extremely useful especially for fine-grain improvers used by middle-aged women.

<Experiment 9: Crystallization of ascorbic acid 2-glucoside-sodium salt> <Experiment 9-1: Preparation of ascorbic acid 2 glucoside-sodium salt crystals>

100 g of a powder containing anhydrous crystals of ascorbic acid 2-glucoside (trade name "AA2G", manufactured by Hayashibara Co., Ltd.) was dissolved in 100 ml of 6N sodium hydroxide, and then 100 ml of methanol was added and stirred, and left to stand at 4 ° C for about 3 weeks. When it was observed by a microscope, the formation of crystals was confirmed. The crystal suspension was filtered through a glass filter, and the precipitated crystals were collected, washed with a 70% aqueous methanol solution containing 0.1 N hydrochloric acid, and dried at 40 ° C to obtain about 35 g of a crystalline powder.

<Experiment 9-2: Review of conditions for formation of ascorbic acid 2-glucoside-sodium salt crystals>

10 ml of a 1 to 10 N sodium hydroxide aqueous solution shown in the following Table 8 was added to 10 g of a powder containing anhydrous crystalline ascorbic acid 2-glucoside (product name "AA2G", manufactured by Hayashibara Co., Ltd.), and dissolved. 10 ml of methanol was added and mixed, and 30 mg of ascorbic acid 2-glucoside-sodium salt crystal obtained in Experiment 9-1 was added as a seed crystal, and allowed to stand at 4 ° C for 24 hours, and the degree of precipitation of crystals was visually investigated. The degree of crystallization is determined by the following four stages: "-": crystals are not precipitated

"+": only a little crystallized

"++": Crystallization is about half of the capacity

"+++": All crystals are precipitated and cured

The results are shown in Table 9.

As shown in Table 9, the powder containing anhydrous crystals of ascorbic acid 2-glucoside was dissolved in a sodium hydroxide aqueous solution of various concentrations such as 5N, 6N, 8N, and 10N, and a sample obtained by adding methanol was used, from which precipitation of respective crystals was confirmed. The amount of precipitation of crystals increases as the concentration of sodium hydroxide increases. Further, when the sodium hydroxide concentration was 4 N or less, the precipitation of crystals could not be confirmed at all. When the concentration of sodium hydroxide is 5N, the molar ratio of ascorbic acid 2-glucoside to sodium in the solution is 1.7, and the formation of ascorbic acid 2-glucoside-sodium salt crystals is known to be relative to ascorbic acid 2-glucoside. Sodium hydroxide having a molar ratio of 1.7 or more is required.

<Experiment 9-3: Ascorbic acid 2-glucoside-sodium salt crystallization>

About 10 g of the crystal powder obtained in Experiment 9-1 was vacuum-dried at 50 ° C for 24 hours, and about 8.4 g of a crystal powder different from the crystal appearance obtained in Experiment 9-1 was obtained. The obtained crystal was considered to be a new crystal different from the crystal obtained in Experiment 9-1.

<Experiment 10: Various analyses regarding the crystallization of ascorbic acid 2-glucoside-sodium salt>

The crystals obtained in Experiments 9-1 and 9-3 were subjected to observation of crystal form, HPLC analysis, measurement of sodium content, measurement of infrared absorption spectrum (FT-IR), and measurement of powder X-ray diffraction pattern.

<Experiment 10-1: Shape of Crystallization>

The crystals obtained in Experiments 9-1 and 9-3 were respectively placed on a glass slide. A phase difference microscope was used to observe the shape of the crystal and to perform photographic shadowing. A photograph of each crystal is shown in Figs. 1 and 2. As seen in Fig. 1, the crystal obtained in Experiment 9-1 was in the form of a thin plate or a column. Further, as seen in Fig. 2, the shape of the crystal obtained in Experiment 9-3 was a plate shape in which a plurality of shapes collapsed.

<Experiment 10-2: HPLC analysis>

The crystals obtained in Experiments 9-1 and 9-3 were each dissolved in an appropriate amount of pure water, and subjected to HPLC analysis under the following conditions. For the control, a powder containing an anhydrous crystalline form of ascorbic acid 2-glucoside (a product name "ascorbic acid 2-glucoside 999", a purity of 99.9% or more, manufactured by Aihara Co., Ltd.) was used, and the analysis was carried out under the same conditions.

<HPLC analysis conditions>

Column: Wakopak Wakobeads T-330 H ⁺ type

(Inner diameter 10mm × length 300mm) (Waiguang Pure Pharmaceutical Industry Co., Ltd.)

Dissolved solution: 0.0001N aqueous solution of nitric acid

Flow rate: 0.5ml/min

Temperature: room temperature

Detection: Differential Refractometer

When the crystals obtained in Experiments 9-1 and 9-3 were dissolved in pure water and subjected to HPLC analysis, in the same manner as in the case of anhydrous ascorbic acid 2-glucoside in any chromatogram, only ascorbic acid 2-glucose was used. The peak of the glycoside was detected, and the purity of ascorbic acid 2-glucoside was about For 100%, the crystals obtained in Experiments 9-1 and 9-3 were confirmed to be crystals containing ascorbic acid 2-glucoside as a constituent component.

<Experiment 10-3: Determination of moisture content>

The moisture content of the crystal powder obtained in the experiments 9-1 and 9-3 was 14.9% by mass and 0.2% by mass as a result of measurement by a usual method of drying under reduced pressure (50 ° C, 24 hours). From the results, it was found that the crystal obtained in Experiment 9-1 contained aqueous crystals of ascorbic acid 2-glucoside, and the crystal obtained in Experiment 9-3 contained anhydrous crystals of ascorbic acid 2-glucoside.

<Experiment 10-4: Determination of sodium content>

In the conversion of anhydrous matter, 25 mg of the anhydrous crystal obtained in Experiment 9-3 was weighed, dissolved in 50 ml of pure water, and diluted 5 times with pure water as a measurement sample. The amount of sodium in the sample was measured using an inductively coupled plasma luminescence spectrometer (ICP-AES) CIROS-120 (manufactured by Rigaku Corporation) under the following conditions.

<ICP-AES measurement conditions>

Plasma power: 1400W

Plasma gas: 13.0L / min

Subsidy gas and atomizing gas: 1.0L/min

Blank sample: 1000% dilution of 60% nitric acid

Sodium calibration line solution: ICP MULTI-ELEMENT STANDARDS IV (manufactured by Merck) is diluted to 0.1~10ppm

The anhydrous crystal obtained in Experiment 9-3 had a sodium content in the solid content of 8.7% by mass. This value is based on the assumption that the anhydrous crystal obtained in Experiment 9-3 contains 1 mol of ascorbic acid 2-glucoside and 1 mol of sodium and 1/2 mol of sodium hydroxide, that is, assuming ascorbic acid 2-glucoside The theoretical value of sodium content at a molar ratio of sodium to 1:1.5 is approximately 8.8 mass%, and thus the resulting ascorbic acid 2-glucoside-sodium salt crystallizes relative to ascorbic acid 2-glucoside 2 molar It can be said that it contains 3 moles of sodium.

Further, as described above, the water content in the hydrous crystal of the ascorbic acid 2-glucoside-sodium salt is about 15% by mass, and if the ascorbic acid 2-glucoside and sodium and sodium hydroxide are assumed to be in the above molar ratio, Then, the molar ratio of the ascorbic acid 2-glucoside to the water molecule is about 1:4, and for the ascorbic acid 2-glucoside 1 molecule, the aqueous crystal system contains 4 molecules of crystal water.

From the results of Experiments 10-1 to 10-4, it was confirmed that the crystal obtained in Experiment 9-1 was a hydrous crystal of ascorbic acid 2-glucoside-sodium salt, and the crystal obtained in Experiment 9-3 was ascorbic acid 2-glucoside-sodium salt. Anhydrous crystals.

<Experiment 10-5: FT-IR spectrum>

To 2 mg of the anhydrous crystalline powder obtained in Experiment 9-3, 200 mg of potassium bromide for infrared absorption spectrum analysis was added, and the mixture was pulverized and mixed in a mortar made of agate, and molded into a tablet for analysis. In the apparatus, an infrared spectrophotometer FTIR-8300 (manufactured by Shimadzu Corporation) was used. Contrast aspect The powder of the ascorbic acid 2-glucoside anhydrous crystal of the reagent grade (trade name "ascorbic acid 2-glucoside 999", purity 99.9% or more, manufactured by Hayashira Co., Ltd.) was used, and the measurement was carried out in the same manner. The results are shown in Figure 3.

As seen in Fig. 3A, in the FT-IR spectrum of the anhydrous crystalline powder of the ascorbic acid 2-glucoside-sodium salt, it was confirmed that there was a large absorption in the vicinity of 1580 cm ^-1 . Further, as seen in Fig. 3B, in the powder containing the ascorbic acid 2-glucoside anhydrous crystal of the control, no absorption spectrum was observed at this position, and it was confirmed that there was a large absorption in the vicinity of 1700 cm ^-1 and 1770 cm ^-1 . The large absorption of the anhydrous crystal of the sodium salt at around 1580 cm ^-1 is presumed to be caused by the stretching vibration of the carbonyl group due to the influence of sodium contained in the crystal. The difference between the FT-IR spectra of the two is considered to be that in the anhydrous crystalline powder of the ascorbic acid 2-glucoside-sodium salt, the ascorbic acid 2-glucoside is present in the form of a salt, whereas the control contains In the powder of ascorbic acid 2-glucoside anhydrous crystal, ascorbic acid 2-glucoside is present in the form of free acid.

<Experiment 10-6: Powder X-ray diffraction diagram>

Using a powder X-ray diffraction apparatus (trade name "X'Pert Pro MPD", manufactured by SPECTRIS Co., Ltd.), the aqueous crystals of the ascorbic acid 2-glucoside-sodium salt obtained in Experiment 9-1 and the results obtained in Experiment 9-3, respectively. An anhydrous crystal was used as a sample, and about 50 mg was placed on a non-reflecting plate, and the Cu-Kα line was irradiated while rotating, and a powder X-ray diffraction pattern was obtained by a reflection method. The resulting powder X-ray diffraction pattern is shown in Figures 4A and B. In contrast, as disclosed in International Publication No. WO2012/033218 A powder containing ascorbic acid 2-glucoside aqueous crystals (purity: 99.5%, manufactured by Linyuan Co., Ltd.) and a powder of ascorbic acid 2-glucoside anhydrous crystals of the test grade (trade name "ascorbic acid 2-glucoside 999", purity 99.9% The above-mentioned, manufactured by Hayashibara Co., Ltd.) was also measured in the same manner, and the obtained powder X-ray diffraction pattern is shown in Figs. 4C and D.

<Cu-Kα line irradiation conditions>

X-ray tube current: 40mA

X-ray tube voltage: 45kV

Wavelength: 1.5405Å

The aqueous crystal of ascorbic acid 2-glucoside-sodium salt, as seen in Figure 4A, exhibits characteristic diffraction peaks at diffraction angles (2θ) of 6.8°, 8.2°, 14.3°, 17.8° and 18.4°, in addition to The anhydrous crystal of ascorbic acid 2-glucoside-sodium salt, as seen in Fig. 4B, exhibits characteristic diffraction peaks at diffraction angles (2θ) of 8.0°, 9.0°, 16.4°, 17.9° and 20.8°. The aqueous crystals of the ascorbic acid 2-glucoside-sodium salt and the anhydrous crystals each show a different powder X-ray diffraction pattern, and these are also known as the powders containing anhydrous ascorbic acid 2-glucoside crystals and anhydrous crystals. The powder X-ray diffraction pattern of the powder is completely different.

From this result, it is understood that both the aqueous crystals and the anhydrous crystals of the ascorbic acid 2-glucoside-sodium salt of the present invention are novel crystals.

In addition, if the anhydrous crystal of ascorbic acid 2-glucoside-sodium salt is left at a temperature of 25 ° C and a relative humidity of 75.2% or more for one night, the moisture content after moisture absorption is about 15% by mass and almost constant, and with ascorbic acid. The aqueous crystallization of the 2-glucoside-sodium salt showed the same powder X-ray diffraction pattern. From this, it is understood that the aqueous crystals can be dried to form anhydrous crystals, and the anhydrous crystals can be converted into water-containing crystals by moisture absorption, and are mutually converted by phase transfer.

<Experiment 10-7: Analysis of single crystal X-ray crystal structure>

2 g of sodium hydroxide containing ascorbic acid 2-glucoside anhydrous crystals (trade name "ascorbic acid 2-glucoside 999", purity 99.9% or more, manufactured by Hayashira Co., Ltd.) was dissolved in 10 ml of 3N sodium hydroxide, and methanol was added thereto. 30 ml, which was mixed, was allowed to stand at 4 ° C for 3 weeks, whereby a single crystal of a hydrous crystal of the ascorbic acid 2-glucoside-sodium salt was precipitated. From the obtained single crystal, an appropriately sized one was selected, coated with paratone oil, and placed on an X-ray diffraction apparatus, and the X-ray diffraction pattern was measured by a vibration photographing method under the following conditions. R-AXIS RAPID-R (manufactured by Rigaku Corporation) was used for the measurement device, and Crystal Structure Ver. 3.8.2 (manufactured by Rigaku Corporation) was used for the analysis software.

<Measurement conditions>

X-ray source: Cu

Output: 50kV-100mA

Incident X-ray: Cu-Kα line

Incident X-ray size: about 0.5mm

Crystal size: 0.3 × 0.2 × 0.2mm

Detector: image board

Measuring temperature: about -170 ° C (nitrogen blowing method)

The single crystal X-ray diffraction pattern is shown in Fig. 5. In the X-ray diffraction pattern, it was confirmed that there were a large number of diffraction spots, and it was confirmed that the crystal was a single crystal. The crystallographic parameters of the obtained aqueous crystals of the ascorbic acid 2-glucoside-sodium salt were summarized in Table 10 by the analysis of the single crystal X-ray crystal structure.

From the obtained X-ray diffraction intensity data, as shown in Table 10, the aqueous crystal of the ascorbic acid 2-glucoside-sodium salt belongs to the orthorhombic system, and the space group is Pbca (#61), and the lattice number is a= 6.9733Å, b=14.4839Å, c=19.3221Å, V=1951.54Å ³ .

<Experiment 11: pH of a blend of ascorbic acid 2-glucoside-sodium salt crystals and ascorbic acid 2-glucoside anhydrous crystals>

The anhydrous crystalline form of the ascorbic acid 2-glucoside-sodium salt obtained by the method of the above experiment 9-3 and the powder containing anhydrous crystalline ascorbic acid 2-glucoside (trade name "ascorbic acid 2-glucoside 999", purity 99.9% or more, Lin Yuan Co., Ltd.) is blended in an absolute amount of 100:0 to 0:100 as shown in Table 11 below, and then dissolved in 10 times the volume of pure water of the blend. It pH. The results are shown in Table 11.

As seen in Table 11, the pH of the aqueous solution of the anhydrous crystalline solution of the ascorbic acid 2-glucoside-sodium salt alone was 13.1, and the pH of the aqueous solution containing the powder of the anhydrous crystalline form of ascorbic acid 2-glucoside alone was 1.7. Further, the pH of the aqueous solution of the anhydrous crystalline form of the ascorbic acid 2-glucoside-sodium salt and the powder containing the anhydrous crystalline form of ascorbic acid 2-glucoside is shown to be in the range of 12.9 to 2.6 in accordance with the blending ratio thereof. The ascorbic acid 2-glucoside-sodium salt and the ascorbic acid 2-glucoside are used, and the ascorbic acid 2-glucoside aqueous solution is made acidic/alkaline by blending them in an appropriate ratio in terms of anhydrate. A wide range of pH is desired, especially when blended in the range of 55:45 to 40:60, which has been confirmed to exhibit a preferred weakly alkaline to weakly acidic pH in the manufacture of cosmetics.

<Experiment 12: Effect of ascorbic acid 2-glucoside-sodium salt on gelling agent>

In order to investigate the influence of the ascorbic acid 2-glucoside-sodium salt in the manufacture of gelatinous cosmetics, nine kinds of carboxyvinyl polymers (Carbopol (manufactured by Nikko Chemical Co., Ltd.), and HIVISWAKO (Wako Pure Chemical Co., Ltd.) described in Table 12 were used. 3 kinds, 3 kinds of AQUPEC (manufactured by Sumitomo Seika Co., Ltd.), preservative and ascorbic acid 2-glucoside as a colloidal agent widely used in the field of cosmetics, and simulation of preparing a gel containing ascorbic acid 2-glucoside experiment. That is, when the ascorbic acid 2-glucoside is added, the pH is adjusted to pH 6.5 with citrate buffer and sodium hydroxide, and the ascorbic acid 2-glucoside-sodium salt is used to prepare for neutralization without citrate buffer. When the gel was near pH 6.5, the properties of the obtained gel were compared.

5 g of each colloidalizing agent and 7.5 g of pentanediol as a preservative were dissolved in 237.5 g of water to prepare a gel base (concentration: 2%). Further, the aqueous crystal of the ascorbic acid 2-glucoside-sodium salt obtained by the method of Experiment 10-1 was dissolved in water to prepare 250 g of an aqueous solution containing ascorbic acid 2-glucoside 20 g (hereinafter referred to as "ascorbic acid 2-glucoside-sodium Saline solution"). To 25 g of each gel base, 25 g of an aqueous solution of ascorbic acid 2-glucoside-sodium salt was added, and water was added thereto to make the total amount 100 g, and a gel having a pH of about 6.5 was prepared. In addition, 20 g of powder containing ascorbic acid 2-glucoside anhydrous crystals (trade name "AA2G", sold by Linyuan Co., Ltd.) was dissolved in 100 g of water, and then citric acid buffer (1% citric acid, 15% sodium citrate) was added. 20 g and 10% sodium hydroxide 24.7 g were prepared to prepare a solution for neutralizing ascorbic acid 2-glucoside (total 164.7 g, hereinafter referred to as "ascorbic acid 2-glucoside neutralized aqueous solution"). To 25 g of each gel base, 16.47 g of an aqueous solution of ascorbic acid 2-glucoside neutralized was added, and 2 g of 10% sodium hydroxide was added thereto, and water was added thereto to make 100 g of the whole amount, and a gel having a pH of about 6.5 was prepared. The pH and gel properties of each of the gels (carboxyvinyl polymer concentration: 0.5%, ascorbic acid 2-glucoside concentration: 2%) were observed, and the results are shown in Table 12.

As seen in Table 12, ascorbic acid 2-glucoside was used, and the gel substrate prepared by neutralizing the citrate buffer and sodium hydroxide was used, and although it was found that partial viscosity was obtained, either of them was fluid. High, can't get the shape that remains as a gel. Further, any gel substrate prepared by using ascorbic acid 2-glucoside-sodium salt maintains viscosity and can be maintained in a colloidal shape. As a result of these, it can be said that if the ascorbic acid 2-glucoside-sodium salt is used, a gel-like cosmetic which is difficult to prepare with ascorbic acid 2-glucoside can be easily produced.

<Experiment 13: Anti-wrinkle effect of lotion>

Based on the square (value is % by mass) shown in Table 13, three kinds of lotions were prepared, that is, the ascorbic acid 2-glucoside without added lotion 1 (control), and the powder containing ascorbic acid 2-glucoside anhydrous crystals was blended. (product name "AA2G", sold by Hayashira Co., Ltd.) 2% by mass, using sodium hydroxide as a neutralizing agent, citric acid and sodium citrate as a pH adjuster, and a blending solution 2, and blending will be described later. The ascorbic acid 2-glucoside-sodium salt anhydrous crystalline powder obtained by the method of Example 2, 2% by mass of the water-repellent powder 3 prepared without the neutralization operation, was subjected to a volunteer test for anti-wrinkle action.

(Making lotion 1): Dissolve (1), (4) to (7) of Table 13 in purified water (14) to prepare an aqueous phase, and mix the polyoxyethylene oleyl alcohol (8) and the flavor in advance ( 10) It is prepared by dissolving in ethanol (9), using an appropriate amount of sodium hydroxide, and adjusting the pH to 6.5.

(Makeup 2): After dissolving (1), (4) to (7) of Table 13 in a part of purified water (14), a powder containing anhydrous crystals of ascorbic acid 2-glucoside (product name "AA2G") , Linyuan Co., Ltd. sold as ascorbic acid 2-glucoside (2), dissolved it, followed by neutralization with sodium hydroxide, and by adding citric acid (11) and sodium citrate (12) as a pH adjuster The pH was adjusted to 6.5, and the remaining purified water was added to prepare an aqueous phase, and the rest was produced in the same manner as the lotion 1.

(Make-up water 3): an ascorbic acid 2-glucoside-sodium salt anhydrous crystalline powder prepared by blending the method of the following Example 2 except for the ascorbic acid 2-glucoside-sodium salt (3), and having a pH of 6.5 The rest is produced in the same manner as the lotion 1.

The lotion 1 (control), the lotion 2, and the lotion 3 obtained above were examined for their anti-wrinkle and anti-friction action. That is, 30 female subjects, aged 37 to 55, who are troubled by wrinkles and fine lines, are randomly divided into 3 groups for each group of 10, and each group is used with any of the lotions 1 to 3, 1 2 times a day (morning and late), continuous use for 4 weeks. During the trial, the subject should try to avoid ordinary daily life in addition to guiding the use of cosmetics that flaunt the effect of wrinkle improvement. After the end of the test period, a questionnaire survey was conducted on all the subjects, including the improvement of wrinkles, fine lines, improvement of skin firmness and feeling of use. In each group, the number of people who responded to wrinkles, fine lines or skin with "improvement effect" and "good sense of use" was summarized in Table 14.

As shown in Table 14, in the case of the lotion 1, the "improvement effect" is applied to the wrinkles, the fine lines, or the skin firmness. The number of the subjects is 2 or less, but the lotions 2 and 3 are Six or more people answered "Improved effect." In addition, in the case of the use of the lotion, there are 3 of the 10 respondents who answered "good" in the lotion 1 but 5 of the lotion 2 and 7 of the lotion 3 answered "good". In addition, during the trial, no one felt skin trouble and there was no problem in safety. From the above results, it is known that a lotion using ascorbic acid 2-glucoside or its sodium salt is compared with ascorbic blood. Acid 2-glucoside is a non-additive lotion that improves wrinkles and fine lines and gives skin firmness.

<Experiment 14: Anti-spot, anti-freckle effect of emulsion>

Based on the square (value is % by mass) shown in Table 15, three types of emulsions (moisturizing emulsions) were obtained, that is, ascorbic acid 2-glucoside without added emulsion 1 (control), blended with ascorbic acid 2-glucoside anhydrous 3% by mass of the crystallized powder (trade name "AA2G", sold by Linyuan Co., Ltd.), and the emulsion 2 which is neutralized and pH-adjusted with sodium hydroxide, and the ascorbic acid 2-glucose obtained by the method of the following Example 2. The glycoside-sodium salt anhydrous crystalline powder was 3% by mass, and after the emulsion 3 prepared by the neutralization operation, the volunteer test for anti-plaque and anti-frecking effect was carried out.

(Emulsion 1): To the purified water (15), (7) to (9) and (14) of Table 14 were added and heated and mixed, and an aqueous phase of pH 7.0 was formed using sodium hydroxide. Further, (1) to (5) of Table 15 were mixed and heated to 70 ° C as an oil phase. The oil phase portion is added to the aqueous phase to carry out preliminary emulsification, and then uniformly emulsified by a homomixer, and after cooling, it is produced by adding triethanolamine (6), carboxyvinyl polymer (10) and perfume (11). Emulsion.

(Emulsion 2): In addition to using ascorbic acid 2-glucoside (12), a powder containing anhydrous crystalline ascorbic acid 2-glucoside (trade name "AA2G", sold by Linyuan Co., Ltd.), dissolved in purified water (14) Part, add sodium hydroxide (14) to neutralize and adjust to pH 7.0, This was produced in the same manner as the emulsion 1 except that this was added last.

(Emulsion 3): In addition to the ascorbic acid 2-glucoside-sodium salt anhydrous crystalline powder prepared by the method of Example 2 described later, as the ascorbic acid 2-glucoside-sodium salt (13), this was dissolved in purified water (14). In some cases, this was added at the end and adjusted to pH 7.0, and the others were produced in the same manner as the emulsion 1.

With respect to the emulsion 1 (control), the emulsion 2 or the emulsion 3 obtained above, the antiplaque and freckle action were investigated. That is, 30 female subjects aged 22 to 51 years old who are plagued by spots and freckles are randomly divided into 3 groups for every 10 units. For each group, the emulsion is used continuously for 4 weeks. Any of the three. In addition, during the trial period, the subjects were also referred to in addition to guiding them to avoid the use of cosmetics that advertised spots and freckles to improve the effect. Guided the general daily life. After the end of the test period, a questionnaire was used to determine the effect of skin spots and freckles. The test results are shown in Table 16.

As shown in Table 16, in the case of the emulsion 1 (control), the spot and the freckles were "improved", and one of the 10 subjects answered "slightly improved", and 2 of the subjects were 2, Seven or more of the emulsions 2 and 3 answered "improved" or "slightly improved". In addition, during the trial, no one felt skin trouble and there was no problem in safety. From the above results, it has been found that an emulsion using ascorbic acid 2-glucoside or a sodium salt thereof is superior to an emulsion in which ascorbic acid 2-glucoside is not added, and is excellent in the effect of improving spots and freckles.

<Experiment 15: Anti-relaxation effect of facial cleanser>

Based on the square (value is % by mass) shown in Table 17, three types of facial cleansers (face creams) are obtained, that is, ascorbic acid 2-glucoside without added facial cleanser 1 (control), blended with ascorbic acid 2 - a granulose anhydrous crystalline powder (trade name "AA2G", sold by Hayashira Co., Ltd.) 2% by mass, using potassium hydroxide for neutralizing and pH-adjusting facial cleanser 2, and blending the method of Example 3 described later Ascorbic acid 2-gluco The glycoside-sodium salt anhydrous crystalline powder was 2% by mass, and after the facial cleanser 3 was obtained without using a pH adjuster, a volunteer test for anti-relaxation was carried out.

(Flossing Agent 1): (11) to (13) of Table 17 were dissolved in purified water (14) as an aqueous phase. Further, (1) to (8) of Table 16 were previously mixed and dissolved, and in the oil phase adjusted to 70 ° C, the aqueous phase was slowly added while stirring, and maintained at 70 ° C to complete the saponification reaction. The mixture was cooled to 50 ° C with stirring, uniformly mixed, and cooled to 25 ° C to prepare a face rinsing agent (washing cream) of pH 9.0.

(Flossing agent 2): In addition to using ascorbic acid 2-glucoside (9), a powder containing anhydrous crystalline ascorbic acid 2-glucoside (trade name "AA2G", sold by Linyuan Co., Ltd.), pre-dissolved in purified water (14) One of them was neutralized with potassium hydroxide, and then mixed with the surface-cleaning agent after cooling, and the other was produced in the same manner as the face-washing agent 1.

(Flossing agent 3): an ascorbic acid 2-glucoside-sodium salt anhydrous crystalline powder prepared by using the method of Example 2 described later as an ascorbic acid 2-glucoside-sodium salt (10), dissolved in one of purified water (14) The part was produced in the same manner as the facial cleanser 1 except that it was blended to the cooled facial cleanser without being neutralized.

The anti-relaxation effect was examined about the above-mentioned facial cleanser 1 (control), facial cleanser 2, or facial cleanser 3. That is, 30 male and female subjects aged 36 to 58 who are plagued by skin relaxation make the male-female ratio in the group almost the same, divided into 3 groups in 10 units, for each group for 4 consecutive weeks. Use any of the facial cleansers 1~3. In addition, during the trial, the subjects were guided to avoid the use of cosmetics that advertised skin sagging improvement effects, and also guided the daily life as much as possible. After the end of the test period, the effect of skin relaxation improvement was determined by questionnaire. The results are shown in Table 18.

As shown in Table 18, in the face-washing agent 1 (control), the answer to the "satisfaction" of the skin was 2, among the 10 subjects, and the respondent "slightly improved" was among the 10 subjects. 2, but in contrast, 8 of the facial cleansers 2 and 3 answered "improved" or "slightly improved". In addition, during the trial, no one felt skin trouble and there was no problem in safety. From the above results, it was found that a facial cleanser using ascorbic acid 2-glucoside or a sodium salt thereof is superior to an anti-ascorbic acid 2-glucoside non-additive facial cleanser in improving the effect of skin relaxation.

<Experiment 16: Whitening and anti-wrinkle effect of beauty liquid>

Based on the surface of Table 19 (value is % by mass), three types of beauty liquids are prepared, that is, a cosmetic liquid 1 (control) in which ascorbic acid 2-glucoside is not added, and a powder containing anhydrous crystals of ascorbic acid 2-glucoside (trade name "AA2G", sold by Hayashira Co., Ltd.) 3 mass%, beauty liquid 2 adjusted to pH 6.5 with sodium hydroxide, and ascorbic acid 2-glucoside-sodium salt obtained by blending the method of Example 3 described later The crystal powder was 3 mass%, and the beauty liquid 3 prepared by using the pH adjuster was not used, and the whitening and the volunteer test for the anti-wrinkle effect were performed.

(Beauty solution 1): According to the blending prescription of Table 19, mix (1)~(5), (12)~(18), add premixed (9)~(11) and homogenize it, add (8), adjust the pH to 6.5 to make a cosmetic liquid.

(Beauty solution 2): In addition to blending with ascorbic acid 2-glucoside anhydrous The crystallization powder (trade name "AA2G", sold by Hayashira Co., Ltd.) was used as the ascorbic acid 2-glucoside (6), and the potassium hydroxide was adjusted to pH 6.5 and used in the same manner as in the cosmetic liquid 1. Manufacturing.

(Beauty Liquid 3): Ascorbic acid 2-glucoside-sodium salt anhydrous crystalline powder prepared by blending the method of Example 2 described later as ascorbic acid 2-glucoside-sodium salt (7), and without potassium hydroxide The mixture was adjusted to pH 6.5 except for the neutralization operation, and the others were produced in the same manner as the cosmetic liquid 1.

The beauty liquid 1 (control), beauty liquid 2 or Beauty liquid 3, to investigate the role of whitening and anti-wrinkle. That is, 30 female subjects aged 26 to 48 who are plagued by dullness and wrinkles of the skin are randomly divided into 3 groups for every 10 units, and for each group, they are continuously used for 4 weeks. Any of the beauty liquids 1 to 3. In addition, during the test period, the subjects were guided to general daily life in addition to avoiding the use of cosmetics that advertised whitening effects and wrinkle improvement effects. After the end of the test period, the skin whitening effect and wrinkle improvement effect were judged by questionnaire. The test results are shown in Table 20.

As shown in Table 20, the beauty liquid 1 (control) has an effect on whitening, and the answer to the "improvement" of wrinkles is one of the 10 subjects, and the answer is "slightly improved", and 10 subjects are examined. There is one. In contrast, 7 of the beauty liquids 2 and 3 answered "improved" or "slightly improved". In addition, during the trial, no one felt skin trouble and there was no problem in safety. From the above results, it was found that a cosmetic liquid using ascorbic acid 2-glucoside or a sodium salt thereof exhibited a whitening effect and an excellent effect on the improvement of wrinkles as compared with the cosmetic liquid in which ascorbic acid 2-glucoside was not added.

Hereinafter, the present invention will be described in more detail based on examples. However, the invention is not limited to the embodiments.

[Example 1] <Cosmetics material>

500 g of a powder containing anhydrous crystals of ascorbic acid 2-glucoside (trade name "AA2G", sold by Linyuan Co., Ltd.) was dissolved in 500 ml of an 8N aqueous sodium hydroxide solution. After adding 750 ml of ethanol thereto, the mixture was stirred, and allowed to stand at 4 ° C for 5 days to precipitate crystals. The precipitated crystals were collected by filtration through a glass filter, washed with a small amount of a 70% aqueous solution of ethanol, and dried and pulverized at 40 ° C to obtain 326 g of a water-containing crystal powder containing ascorbic acid 2-glucoside-sodium salt.

This product is a novel crystalline powder containing ascorbic acid 2-glucoside. It can be applied to cosmetic materials as well as cosmeceuticals, pharmaceuticals, and foods in the same manner as conventional powders containing ascorbic acid 2-glucoside anhydrous crystals. Etc. Since the aqueous solution of the product exhibits alkalinity, it can be applied to the production of a product which is inconsistent when the method of neutralizing ascorbic acid 2-glucoside by alkali is conventionally used.

[Embodiment 2] <Cosmetics material>

100 parts by mass of the aqueous crystal powder containing ascorbic acid 2-glucoside-sodium salt obtained by the method of Example 1 was dried at 50 ° C for 24 hours under reduced pressure, and then pulverized to obtain 2-glucoside-sodium salt containing ascorbic acid. no The water crystallized powder was 81 parts by mass.

This product is a novel crystalline powder containing ascorbic acid 2-glucoside. It can be applied to cosmetic materials as well as cosmeceuticals, pharmaceuticals, and foods in the same manner as conventional powders containing ascorbic acid 2-glucoside anhydrous crystals. Etc. Since the aqueous solution of the product exhibits alkalinity, it can be applied to the production of a product which is inconsistent when the method of neutralizing ascorbic acid 2-glucoside by alkali is conventionally used.

[Example 3] <Cosmetics material>

To 55 parts by mass of the ascorbic acid 2-glucoside-sodium salt anhydrous crystalline powder obtained by the method of Example 2, the powder containing anhydrous crystalline ascorbic acid 2-glucoside was uniformly mixed (trade name "AA2G", Linyuan Co., Ltd. 45 parts by mass, and a powdery cosmetic material was obtained.

This product is a novel blend of powder containing ascorbic acid 2-glucoside-sodium salt anhydrous crystals and a powder of anhydrous crystalline form of ascorbic acid 2-glucoside from the past, and the conventional ascorbic acid 2-glucoside anhydrous Similarly, the crystal powder can be applied to a cosmetic material, and can also be applied to materials such as cosmeceuticals, pharmaceuticals, and foods. Further, since the aqueous solution of the product exhibits weak alkalinity, it can be more easily adjusted to a desired pH as compared with the case of using a powder containing anhydrous crystals of ascorbic acid 2-glucoside.

[Example 4] <Cosmetics material>

The hydrated crystal powder containing ascorbic acid 2-glucoside-sodium salt obtained by the method of Example 1 is uniformly mixed with anhydrous crystalline powder of ascorbic acid 2-glucoside in terms of 50 parts by mass in terms of anhydrate (product) 50 parts by mass of "AA2G" and Linyuan Co., Ltd.), and a powdery cosmetic material was obtained.

This product is a novel blend of a water-containing crystalline powder containing ascorbic acid 2-glucoside-sodium salt and a conventionally used powder containing ascorbic acid 2-glucoside anhydrous crystals, and a conventional ascorbic acid 2-glucoside Similarly, the powder of anhydrous crystal can be applied to a cosmetic material, and can also be applied to materials such as cosmeceuticals, pharmaceuticals, and foods. Further, since the aqueous solution of the product exhibits weak acidity, it can be more easily adjusted to a desired pH as compared with the case of using a powder containing anhydrous crystals of ascorbic acid 2-glucoside.

[Example 5] <lotion> (mixing prescription)

After the components (1) to (4) of the above-mentioned blending prescription are dissolved in purified water (9), the components (5) to (8) which have been mixed are slowly added and mixed to prepare a lotion. This product is an excellent lotion that exerts a stable anti-wrinkle effect, and is not only anti-wrinkle and anti-friction effect, but also suitable for anti-aging makeup which is excellent for whitening effect and even anti-plaque and anti-relaxation effect. water. In addition, the lotion is excellent in antiseptic effect and moisturizing property, and has low irritation to the skin, and also inhibits active ingredients such as ascorbic acid 2-glucoside. Precipitating and excellent stability.

[Embodiment 6] <lotion> (mixing prescription)

(Production method)

The components (1) and (2) of the above-mentioned blending formulation are heated to 70 ° C and uniformly mixed, and a part of the water in which the components (3), (4) and purified water (9) are mixed is added thereto. Part and heated (A phase). Arbutin (7) is dissolved in the remaining purified water (9) (phase B). After slowly adding the phase A to the phase B, the components (5) and (8) are further mixed, and (6) is added to obtain a lotion in the form of a microemulsion.

This product is transparent and stable due to the formation of microemulsion. It is an excellent lotion that stabilizes and exerts anti-wrinkle effect, and is not only anti-wrinkle and anti-friction effect, but also suitable for whitening and even anti-whitening. An anti-aging lotion that is excellent in plaque and anti-relaxation. In addition, this lotion is excellent in antiseptic effect and moisturizing property because it is blended with 1,3-butanediol, and is excellent in the point of low irritation to the skin.

[Embodiment 7] <emulsion> (mixing prescription)

The above components (1), (3), (10), (11) and purified water (14) were mixed as an aqueous phase. Next, the components (2), (5) to (9), (12), and (13) are heated and mixed as an oil phase. The aqueous phase was added to the oil phase, uniformly mixed, cooled, and the component (4) was added and homogeneously mixed to obtain an emulsion. This product is an excellent emulsion that exerts a stable anti-wrinkle effect. It is not only anti-wrinkle and anti-frost, but also effective for anti-aging for whitening, even anti-plaque and anti-relaxation. Emulsion.

[Embodiment 8] <gel-like emulsion> (mixing prescription)

In a part of the purified water (18), after dissolving the components (11) to (16), the components (1) to (10) and (17) are added and emulsified by a usual method to prepare a gel emulsion. This product is a cosmetic gel that is excellent in whitening effect, non-sticky and has a good feeling of use while exerting a stable anti-wrinkle effect. Further, since the citrate buffer solution is not used and the concentration of the lower salt is lower than that of the lower salt, it can be used as an excellent gel emulsion for anti-aging.

[Embodiment 9] <Cosmetic lotion> (mixing prescription)

(12) Purified water residue

According to the above prescription, the blended components are mixed by a usual method, and then an appropriate amount of the flavor is added to prepare an emulsion. This product is useful as an anti-aging emulsion which is excellent in whitening action while exerting a firm anti-wrinkle and anti-fine effect, and which has no sticky feeling even when applied to the skin.

[Embodiment 10] <Cosmetic Cream> (mixing prescription)

(13) purified water residual

The components (6) and (7) were added to the purified water (13), and the mixture was heated to 60 ° C to prepare an aqueous phase. Further, the components (1) to (5) and (9) to (12) were mixed, and the mixture was heated to 70 ° C to prepare an oil phase, which was added to the previously prepared aqueous phase. After adding the component (8), it is emulsified by a usual method to produce a cream. This product can be used as an anti-aging cosmetic cream which is excellent in whitening effect, non-sticky and has a good feeling of use while exerting a stable anti-wrinkle effect.

[Example 11] <Cosmetic Cream> (mixing prescription)

The components (1) to (14) and (21) of the above prescription are heated and mixed as an oil phase. Next, the components (15) to (18), (20), and (22) are mixed as an aqueous phase. The aqueous phase is mixed into the oil phase, and after cooling, the component (19) is added and mixed to prepare a cream. This product is used as an anti-aging cosmetic cream which is excellent in whitening effect, non-sticky and has a good feeling of use while exerting an anti-wrinkle effect.

[Embodiment 12] <Beauty solution> (mixing prescription)

Blending fraction (% by mass)

According to the above prescription, the blended components are mixed by a usual method to prepare a cosmetic liquid. This product can be used as an anti-aging beauty lotion which is excellent in whitening action while exerting a firm anti-wrinkle and anti-fine effect, and which has no sticky feeling even when applied to the skin.

[Example 13] <mask> (mixing prescription)

According to the above prescription, the blended components are mixed by a usual method to prepare a mask. This product can be used as an anti-aging mask which is excellent in whitening effect while exerting a stable anti-wrinkle and anti-fine effect. It is easy to clean after application on the skin.

[Embodiment 14] <washing foam> (mixing prescription)

The facial cleansing foam is prepared by the usual method according to the above mixing. This product is also excellent in whitening action and anti-plaque effect, and it can be used as an anti-aging facial cleansing foam because it exerts a stable anti-wrinkle and anti-fine effect.

[Example 15] <liquid soap> (mixing prescription)

The liquid soap is prepared by a conventional method according to the above blending prescription. This product is also excellent in whitening action and anti-plaque effect, and it can be used as a liquid soap for anti-aging because it exerts a stable anti-wrinkle and anti-fine effect.

[Example 16] <Bathing milk> (mixing prescription)

According to the above blending prescription, the shower gel is prepared by a conventional method. This product is also used as an anti-aging shower gel because it exerts a stable anti-wrinkle and anti-fine effect, and also has excellent whitening action and anti-plaque effect, and has a moist cleansing effect.

[Example 17] <clean> (mixing prescription)

The cleansing cream is prepared by a conventional method according to the above blending prescription. This product is a cleansing cream that is used for cleansing and removing makeup on the skin. In addition, it can be used as an anti-aging cleansing cream which exhibits an excellent effect on whitening and anti-plaque while exerting a stable anti-wrinkle and anti-friction effect.

[Embodiment 18] <Whitening sunscreen (water-based emulsion type)> (mixing prescription)

(Production method)

A. The components (1) to (3) and (5) are heated to 75 ° C and uniformly mixed and dissolved.

B. The components (4), (6) to (10), (14) and (15) are heated to 75 ° C and uniformly mixed and dissolved.

C. Add B to A to emulsify.

D. Cool C and add ingredients (11) to (13) to obtain a sunscreen (whitening type).

This product can be used as a moisturizing effect on the skin while maintaining a calming whitening effect. It is also excellent in anti-wrinkle and anti-fine lines. It has excellent moisturizing effect on the skin, and it has excellent moisturizing effect even on the skin. A sunscreen agent for anti-aging (water-based emulsion type) which is excellent in stability over time.

[Embodiment 19] <Whitening lotion (oil type emulsified type)> (mixing prescription)

(Production method)

A. The components (1) to (4) are heated to 75 ° C and uniformly mixed and dissolved.

B. The components (5) to (10), (12) and (13) are heated to 75 ° C and uniformly mixed and dissolved.

C. Add B to A to emulsify.

D. C was cooled, and component (11) was added to obtain a whitening emulsion (oil-in-water emulsion type).

This product can be used as a moisturizing anti-wrinkle and anti-fine effect, and it is also excellent in whitening effect and anti-plaque effect. It is uniform on the skin, has no sticky feeling, and the skin is smooth and smooth. It is excellent in effect, and it is an emulsion for anti-aging whitening (water-based emulsion type) which is excellent in stability over time.

[Example 20] <Skin conversion improves cosmetic substrate> (mixing prescription)

Mixing the above ingredients (1)~(7) at room temperature After stirring, mixing, and dissolving, the membrane was filtered through a membrane to prepare a cosmetic substrate (pH 6.0), which was converted into a light-shielding container. This product is blended into various cosmetics, in addition to imparting a transformation-improving effect to the skin, while also imparting anti-wrinkle effect, anti-friction effect, whitening effect, and even anti-plaque effect and anti-relaxation effect. In particular, in this product, the olive leaf extract and the α-glucosyl rutin are blended with the conversion improving effect, and the action of the component (1) is complementary, in addition to effectively imparting a conversion improving effect on the immediate skin. In addition, it is also very useful at the same time, effectively imparting an effect of protecting the skin from ultraviolet rays or an antioxidant effect. Moreover, it goes without saying that it is for the so-called old-age generation, even for middle-aged women, this product is suitable for incorporation into various cosmetics as a ready-to-use fine line improving agent. In addition, the appropriate amount of various cosmetics blended with this product, for busy women who are busy with work every day and care for the skin, if applied to the skin before going to bed at night, the active ingredients will be effective in bedtime. It penetrates into the skin and instantly improves the skin's transformation.

[Example 21] <Skin conversion improves cosmetic substrate> (mixing prescription)

The components (1) to (7) of the above-mentioned blending formulation were stirred, mixed, and dissolved at room temperature, and then adjusted to pH 6.0, and the membranes were filtered to prepare a cosmetic substrate for conversion of two types of skin. This product is formulated to blend into various cosmetics to impart a conversion-improving effect to the skin, while imparting anti-wrinkle action, anti-friction effect, whitening effect, and even anti-plaque action and anti-relaxation effect. In particular, in this product, the effect of the component (1) is complemented by the addition of the Eucommia leaf extract, the Ganoderma lucidum extract or the cockroach extract having the conversion improving effect and the inhibition of the saccharification reaction, thereby imparting immediate effect. The skin is converted and improved, and the aging effect of the skin is effectively exerted. Further, the Eucommia ulmoides leaf extract having an inhibitory effect on the saccharification reaction in combination with ascorbic acid 2-glucoside can effectively inhibit the formation of advanced glycation end products (AGEs), in addition to reducing or even inhibiting AGEs. In addition to the deposition of skin tissue, in the process of producing AGEs, disorderly cross-linking occurs in the molecules and molecules of collagen, which reduces or even inhibits the physical and physiological changes caused by collagen. Therefore, it can effectively prevent or even improve the aging of skin such as wrinkles, rough skin, dullness, or firmness. Again, for the package Containing so-called middle-aged women of the old age, this product is suitable for blending into various cosmetics as a fine-effect improver. In addition, the appropriate amount of various cosmetics blended with this product, for busy women who are busy with work every day and care for the skin, if applied to the skin before going to bed at night, the active ingredients will be effective in bedtime. It penetrates into the skin and instantly improves the skin's transformation.

[Example 22] <Skin conversion improves cosmetic substrate> (mixing prescription)

Any one of the extracts shown in the above-mentioned ingredients (1), (2), and (3) and (4) to (6) are stirred, mixed, and dissolved at room temperature, and then filtered by a membrane. In order to modulate the skin, the cosmetic base material (pH 6.0) was prepared, and it was filled in a light-shielding container, and 17 types of skin conversion-improving cosmetic base materials were obtained. This product is blended into various cosmetics, in addition to imparting a transformation-improving effect to the skin, while also imparting anti-wrinkle effect, anti-friction effect, whitening effect, and even anti-plaque effect and anti-relaxation effect. In particular, this product is blended with the plant extract which has a skin-sweating-improving effect, and complements the action of the component (1), in addition to effectively imparting a conversion-improving effect to the immediate skin, and at the same time effectively imparting It is extremely useful at this point because it protects the skin from the action of UV rays or has an antioxidant effect. Moreover, it goes without saying that the so-called old-age generation, even for middle-aged women, this product is suitable for incorporation into various cosmetics as a ready-to-use fine line improving agent. In addition, the appropriate amount of various cosmetics blended with this product, for busy women who are busy with work every day and care for the skin, if applied to the skin before going to bed at night, the active ingredients will be effective in bedtime. It penetrates into the skin and instantly improves the skin's transformation.

[Example 23] <Anti-corrosion and sterilization cosmetic substrate> (mixing prescription)

Mixing, mixing, and dissolving each of the components (1) and (4) to (9), and (2) and (3) of the above-mentioned blending formula, and then mixing the two, and adjusting At pH 6.0, four kinds of antiseptic and bactericidal cosmetic substrates were prepared by membrane filtration, and filled into a light-shielding container. In particular, in this product, the extract of the peony which inhibits the saccharification reaction can be blended, and the action of the component (1) complements, thereby significantly imparting a conversion-improving effect to the skin, and at the same time effectively exerting the aging inhibition of the skin. effect. In addition, this product can be blended in a variety of cosmetics according to the desired amount, and is a liquid makeup that imparts anti-wrinkle action, anti-friction effect, whitening effect, even anti-plaque action and anti-relaxation effect. The base material is particularly suitable as a ready-to-use fine line improving agent for middle-aged women of the so-called aging age, and is suitable for blending into various cosmetics. Furthermore, in this product, due to the antiseptic effect, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol or 1,2-octanediol When any one of the selected ones is blended with the photoreceptor 201 having excellent compatibility with the above, it is excellent in anticorrosive effect by blending it into various cosmetics in an appropriate amount. In addition, this product is blended with pullulan and is complementary to the component (1), and is suitable as a cosmetic substrate which can effectively impart moisturizing action to the skin. In addition, the appropriate amount of various cosmetics blended with this product, for busy women who are busy with work every day and care for the skin, if applied to the skin before bed at night, the active ingredients will be effective in bedtime. It penetrates into the skin and instantly improves the conversion of the skin.

[Example 24] <Skin conversion improves cosmetic substrate> (mixing prescription)

The ingredients (1) to (8) to be blended are stirred, mixed, and dissolved while being heated, and then filtered by a membrane to prepare a skin conversion conversion cosmetic substrate (pH 6.0), and filled thereinto. In a light-shielding container. In particular, in this product, it is possible to effectively improve by blending the wild strawberry extract with the conversion improving effect and the equol which has both the conversion improving effect and the inhibition of the saccharification reaction, and complementing the action of the component (1). It transforms the skin and exerts a stable anti-wrinkle effect, anti-frost effect, whitening effect, even anti-plaque effect and anti-relaxation effect. In addition, in order to include middle-aged women of the so-called aging age, this product is suitable for incorporation into various cosmetics as a ready-to-use fine line improving agent. In addition, the appropriate amount of various cosmetics blended with this product, for busy women who are busy with work every day and care for the skin, if applied to the skin before going to bed at night, the active ingredients will be effective in bedtime. It penetrates into the skin and instantly improves the skin's transformation.

[Example 25] <Skin conversion improves cosmetic substrate> (mixing prescription)

Blending fraction (% by mass)

The mixture of any one of the components (1), (2), and (3), and (4) to (6), which were mixed as described above, were stirred and mixed at room temperature, and then adjusted to pH 6.0 by means of a film. Filtration was carried out to prepare a cosmetic substrate for conversion of 32 types of skin, and it was filled in a light-shielding container. In particular, due to the blendability in this product, it has a conversion improving effect and/or a saccharification reaction inhibiting effect. The plant extract or other ingredients complement the action of the component (1), and the skin is converted and improved, and the aging effect of the skin is effectively exerted. In addition, this product can be blended in a variety of cosmetics according to the desired amount, and is used for liquid makeup for imparting anti-wrinkle action, anti-friction action, whitening effect, even anti-plaque action and anti-relaxation effect. The substrate is particularly suitable as a ready-to-use fine line improving agent for middle-aged women of the so-called aging age, and is suitable for blending into various cosmetics. In addition, the appropriate amount of various cosmetics blended with this product, for busy women who are busy with work every day and care for the skin, if applied to the skin before going to bed at night, the active ingredients will be effective in bedtime. It penetrates into the skin and instantly improves the skin's transformation.

[Example 26] <Skin conversion improver>

Four types of conversion improving agents for the skin of the present invention were prepared according to the following blending prescription. That is, in the case of the following component (17), the conversion of the skin obtained in Example 24 using Example 20, Example 21 (in the conversion of two types of skin to improve the cosmetic base material) A cosmetic base material or a powder containing anhydrous crystals of ascorbic acid 2-glucoside is improved.

<Test cream> (mixing prescription)

Blending fraction (% by mass)

The above-mentioned four types of skin conversion improvers all have excellent fine grain improving effects, and are extremely useful as an improvement in fine lines with age, and include immediate effects for middle-aged women of the so-called middle-aged generation. Anti-wrinkle improver. Further, the conversion improving agent of the skin prepared by using the cosmetic substrate obtained by the conversion of the skin obtained in Example 21 or 24 is blended with ascorbic acid 2-glucoside and other components having a conversion improving effect and a saccharification reaction inhibiting action, Compared with the skin of Example 20 in which the ascorbic acid 2-glucoside and the component having only the conversion improving effect are blended, the conversion improving agent for the skin prepared by the cosmetic substrate is improved, and the skin conversion can be further improved. Speed improvement. Moreover, the conversion improving agent of the skin prepared by the cosmetic base material was improved by the conversion of the skin of Example 20, and the component (17) was compared with the skin prepared by using the powder containing anhydrous crystalline ascorbic acid 2-glucoside. The conversion improver can improve the conversion speed of the skin.

[Industrial availability]

The anti-aging skin external composition of the present invention, or a base cosmetic containing the composition, such as a lotion, a facial cleanser, a cosmetic liquid, an emulsion or a cream, can achieve excellent anti-wrinkle, anti-fine lines, and anti-plaque And the anti-relaxation effect is extremely effective as a means to achieve the common aspirations of the young people forever.

Further, the anti-aging skin external composition of the present invention, or A base cosmetic containing a lotion, a face lotion, a cosmetic liquid, an emulsion or a cream containing the composition can be easily produced by a production method including a step of mixing an active ingredient with an aqueous medium as a base, in particular In the case of using ascorbic acid 2-glucoside or a sodium salt thereof as a preferred active ingredient, in the case of using a crystalline form, the advantage of using a high-purity raw material having less impurities, first of all, it is possible to obtain a predetermined knowledge. The advantage of being extremely excellent in physical properties can be expected.

Further, in the production method of the present invention, when the ascorbic acid 2-glucoside-sodium salt crystal is used in combination with the ascorbic acid 2-glucoside anhydrous crystal, the alkali blending ratio can be omitted without appropriately adjusting the blend ratio of the two used. Ascorbic acid 2-glucoside, and the pH of the product can be adjusted to a predetermined range, the anti-aging skin external composition of the present invention or a lotion, a facial cleanser, a cosmetic liquid, an emulsion or a cream containing the composition The basic cosmetics have the advantage of being easily manufactured in fewer steps. The present invention has such an excellent advantage that it is extremely useful in the industry.

Claims (7)

A crystal of a sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid. The crystal of the sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid described in claim 1 is in a powder X-ray diffraction at a diffraction angle (2θ) of 6.8°, 8.2°, 14.3. °, 17.8 °, and 18.4 ° showing the hydrothermal crystals of the 2-O-α-D-glucosyl-L-ascorbate sodium salt of the diffraction peak, or at a diffraction angle (2θ) of 8.0°, 9.0°, 16.4° 17.9°, and 20.8° show anhydrous crystals of the 2-O-α-D-glucosyl-L-ascorbate sodium salt of the diffraction peak. The crystal of the sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid described in claim 2, wherein the aqueous crystal of the sodium 2-O-α-D-glucosyl-L-ascorbate belongs to the oblique The square system is, and the space group is Pbca (#61), the lattice constant is a=6.9733Å, b=14.4839Å, c=19.3221Å, V=1951.54Å ³ . A method for producing a crystal of a sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid according to any one of claims 1 to 3, which comprises 2-O-α-D-gluco a step of dissolving glycosyl-L-ascorbic acid in an aqueous sodium hydroxide solution, a step of adding an organic solvent, and a step of allowing the crystal of sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid to stand still to be precipitated. And the step of taking the crystal after precipitation. A composition comprising the crystal of the sodium salt of 2-O-α-D-glucosyl-L-ascorbic acid according to any one of claims 1 to 3. The composition according to claim 5, which further comprises L-ascorbic acid or 2-O-α-D-glucosyl-L-ascorbic acid. The composition of claim 6, wherein the 2-O-α-D-glucose The blend ratio of crystallization of basal-L-ascorbic acid to its sodium salt is in the range of 60:40 to 45:55 by mass ratio in terms of anhydrate.