CN115025026B - Natural plant extract composition with relieving, repairing and anti-allergic effects - Google Patents
Natural plant extract composition with relieving, repairing and anti-allergic effects Download PDFInfo
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- CN115025026B CN115025026B CN202210632615.0A CN202210632615A CN115025026B CN 115025026 B CN115025026 B CN 115025026B CN 202210632615 A CN202210632615 A CN 202210632615A CN 115025026 B CN115025026 B CN 115025026B
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Epidemiology (AREA)
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- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to a natural plant extract composition with effects of relieving, repairing and resisting allergy. The composition comprises, by weight, 3-5 parts of gentian root extract, 3-5 parts of crocus sativus flower extract, 3-5 parts of paeonia lactiflora root extract, 2-4 parts of centella asiatica extract and 3-5 parts of olive leaf extract. In the composition, radix Gentianae extract, herba Centellae extract and radix Paeoniae extract are mutually matched to jointly control skin inflammation; the olive leaf extract, the crocus sativus flower extract and the paeonia lactiflora root extract synergistically inhibit the release of histamine in a body, and improve the problems of skin allergy, itching and stinging. In addition, the paeonia lactiflora root extract and the centella asiatica extract also have the effects of increasing the hydration degree of the stratum corneum and enhancing the skin moisture, and help the skin to be in a more stable state.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a natural plant extract composition with effects of relieving, repairing and resisting sensitization.
Background
The skin is the organ with the largest area of the human body, is one of the most important organs, and plays roles in protecting the body organ, resisting invasion of microorganisms, bacteria and the like in the external environment, participating in regulation of the body temperature and sensing external matters contacted with the skin. In recent years, with the deterioration of environmental quality, the increase of working pressure and the abuse of hormones on the skin surface caused by the transition pursuit of rapid efficacy of some consumers or manufacturers, people have poorer tolerance to external stimulus, and skin allergy phenomenon is more frequent.
At present, the exact meaning of sensitive skin is not agreed, and the sensitive skin has the characteristics of unknown etiology, high incidence rate, difficult radical treatment and the like, is generally considered to be a highly intolerant skin state, generally has reduced tolerance to stimulus, and a series of abnormal sensory reactions appear, generally starts from a thin and tender part of the skin, gradually develops to ears and necks, and seriously spreads to the whole body. Sensitive skin is skin that is in a state of high vigilance at any time, care is taken with particular care, and repair is difficult.
At present, most of common cosmetics with skin soothing effect on the market improve the moisturizing effect so as to achieve the repairing effect. For example, patent application CN113730322a discloses an anti-allergic and soothing cosmetic comprising the following components: the anti-aging, moisturizing and soothing effects of the cosmetics are improved through the synergistic effect of the components. But only the skin irritation can be relieved briefly by moisturizing, and the problems that fragile sensitive skin is easy to feel stinging and itching, and is easy to reddish and has red blood streaks can not be fundamentally solved.
Disclosure of Invention
Based on the defects in the prior art, the invention provides the natural plant extract composition with the effects of relieving, repairing and resisting the sensitization, and the obvious effects of diminishing inflammation, preserving moisture, relieving and repairing are realized through the mutual synergistic cooperation of various plant extracts in the composition, so that the state of the sensitization skin is improved.
The invention provides a natural plant extract composition with relieving, repairing and anti-allergic effects, which comprises, by weight, 3-5 parts of gentian extract, 3-5 parts of crocus sativus flower extract, 3-5 parts of paeonia lactiflora root extract, 2-4 parts of centella asiatica extract and 3-5 parts of olive leaf extract.
Preferably, the natural plant extract composition comprises, by weight, 4 parts of gentian extract, 4 parts of crocus sativus flower extract, 4 parts of paeonia lactiflora root extract, 3 parts of centella asiatica extract and 4 parts of olive leaf extract.
Preferably, the natural plant extract composition with the effects of relieving, repairing and resisting allergy further comprises 50-68 parts by weight of water.
Preferably, the preparation method of the gentian root extract comprises the following steps: pulverizing radix Gentianae, adding water and enzyme for enzymolysis, heating for extraction, pouring the extractive solution into macroporous resin, eluting with water, discharging the eluate, eluting with ethanol, collecting the eluate, and concentrating.
Preferably, the enzyme is selected from cellulases and/or beta-glucosidases, preferably cellulases and beta-glucosidases in a mass ratio of 2-5:1. The preparation efficiency of the gentian extract is improved in an enzymolysis mode, and the cell walls of the gentian are rapidly damaged by the cellulase and the beta-glucosidase, so that effective substances in cells are released, and the activity of the gentian extract is improved.
Preferably, the mass ratio of gentian root to enzyme is 100:3-6.
Preferably, the enzymolysis temperature of the gentian root is 35-50 ℃ and the enzymolysis time is 2-4h.
Preferably, the ratio of the mass of gentian root to the volume of water is 1:6-8, and the ratio of the mass to the volume is g/mL.
Preferably, the extraction heating temperature of radix Gentianae is 50-60deg.C, and the extraction time is 30-60min.
Preferably, the macroporous resin is selected from one or more of AB-8, XAD-2, D-101 and WLD-3.
Preferably, the ethanol is 65-80% by volume when the gentian extract is eluted.
Preferably, the preparation method of the crocus sativus flower extract comprises the following steps: drying flower of crocus sativus, pulverizing, extracting with water, and concentrating the extractive solution.
Preferably, the crocus sativus flower is dried in vacuum at 40-50deg.C for 20-30h. The vacuum drying method at low temperature is adopted to avoid loss of effective components in crocus sativus flower and improve activity of the extract.
Preferably, the ratio of the mass of the crocus sativus flower to the volume of water is 1:9-12, and the ratio of the mass to the volume is g/mL.
Preferably, the extraction temperature of crocus sativus flower is 40-50deg.C, and the extraction time is 50-60min.
Preferably, the preparation method of the paeonia lactiflora root extract comprises the following steps: extracting radix Paeoniae powder with ethanol, pouring the extractive solution into macroporous resin, eluting with water, collecting eluate, and concentrating.
Preferably, the volume ratio of the mass of the paeonia lactiflora root to the ethanol is 1:7-9, and the ratio of the mass to the volume is g/mL.
Preferably, the volume percentage of ethanol used in the extraction of the paeonia lactiflora roots is 20-40%.
Preferably, the extraction temperature of the paeonia lactiflora root is 50-60 ℃ and the extraction time is 30-40min.
Preferably, the macroporous resin used in the extraction of the paeonia lactiflora roots is D-101.
Preferably, the preparation method of the centella asiatica extract comprises the following steps: steaming herba Centellae, extracting with absolute ethanol, pouring the extractive solution into macroporous resin, eluting with water, collecting eluate, and concentrating.
Preferably, the steaming temperature of centella asiatica is 90-100 ℃, and the steaming time is 5-10min.
Preferably, the volume ratio of the mass of centella asiatica to absolute ethyl alcohol is 1:8-10, and the ratio of the mass to the volume is g/mL.
Preferably, the extraction temperature of centella asiatica is 80-90 ℃, and the extraction time is 90-120min.
Preferably, the macroporous resin is X-5 during centella asiatica extraction.
Preferably, the preparation method of the olive leaf extract comprises the following steps: drying and pulverizing olive leaf, adding beta-cyclodextrin, grinding, soaking in acetone, separating solid from liquid, adding ethanol into the solid residue, ultrasonic extracting, concentrating the extractive solution, adding into polyamide resin, eluting with ethanol, and concentrating the eluate.
Preferably, the mass ratio of the olive leaves to the beta-cyclodextrin is 100:3-7. The cyclodextrin is used for wrapping the active ingredients in the olive leaves, so that the damage of the olive leaves during the subsequent removal of pigment impurities is avoided.
Preferably, the volume of the olive leaf and the acetone is 1:5-8, and the ratio of the mass to the volume is g/mL. Acetone is added to fully remove pigment impurities in olive leaves, so that the subsequent extraction efficiency is improved.
Preferably, the volume ratio of the mass of the olive leaves to the ethanol is 1:8-10, and the ratio of the mass to the volume is g/mL.
Preferably, the volume percentage of ethanol used in the extraction of the olive leaves is 60-80%.
Preferably, the ultrasonic power of the olive leaf is 300-350w, the ultrasonic time is 20-40min, and the cyclodextrin-coated active ingredient is fully released.
Preferably, the extraction temperature of the olive leaf is 70-90 ℃, and the extraction time is 20-50min.
Preferably, the extract of olive leaves is concentrated to 1/40-1/20 of the original volume.
Preferably, the volume percentage of ethanol used in the olive She Xituo is 75-95%.
The invention further provides a preparation method of the natural plant extract composition, which comprises the following steps: and uniformly mixing the raw materials to obtain the composition.
The invention also provides a skin care product with the effects of relieving, repairing and resisting allergy, which comprises the composition and auxiliary materials in the field of cosmetics.
Preferably, the composition is added to the skin care product in an amount of 3-8wt%.
The beneficial effects of the invention are as follows:
1. the invention provides a natural plant extract composition with relieving, repairing and anti-allergic effects, which comprises, by weight, 3-5 parts of gentian extract, 3-5 parts of crocus sativus flower extract, 3-5 parts of paeonia lactiflora root extract, 2-4 parts of centella asiatica extract and 3-5 parts of olive leaf extract. In the composition, the radix gentianae extract reduces the damage of external stimulus to skin, the centella asiatica extract reduces the generation of in vivo inflammatory mediators, the radix paeoniae alba extract inhibits bacterial fungi, and the three are mutually matched to control skin inflammation from the inside to the outside; the olive leaf extract can inhibit the release of histamine and reduce skin allergy, the crocus sativus flower extract can improve skin blood circulation and promote skin metabolism, so that skin itch is improved, paeoniflorin is rich in paeoniflorin in the paeonia lactiflora root extract, and the skin stinging problem can be relieved. In addition, radix Paeoniae extract and herba Centellae extract also have effects of increasing hydration degree of horny layer and enhancing skin moisture.
2. The invention researches the extraction method of each component in the composition, and discovers that the active ingredients in the composition prepared by the preparation method provided by the invention are increased, and the formed composition has obvious synergistic effect, and can improve the sensitive skin state in various aspects from anti-inflammatory, anti-allergic, pain relieving, itching relieving and moisturizing. In particular, the gentian root extract is prepared by using a complex enzyme enzymolysis mode, plant cell walls are subjected to enzymolysis and then are extracted, the extraction efficiency and the activity of the extract are improved, and in the research and development process, the crocus sativus flower, the paeonia lactiflora root, the centella asiatica and the olive leaves are treated by adopting the enzymolysis mode, so that no better effect is obtained. In addition, the olive leaf is embedded by beta-cyclodextrin during extraction, so that the destruction of active ingredients in the subsequent acetone decoloring process is prevented, and the activity of the extract is greatly improved.
3. The composition provided by the invention can be applied to the preparation of various cosmetics, such as moisturizing water, emulsion, essence, face cream, facial mask and the like, has smooth skin feel, is safe and nonirritating, has obvious effects of relieving, repairing and resisting allergy, and has wide application value.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The embodiment provides a natural plant extract composition with relieving, repairing and anti-allergic effects, which comprises 4g of gentian root extract, 4g of crocus sativus flower extract, 4g of paeonia lactiflora root extract, 3g of centella asiatica extract, 4g of olive leaf extract and 60g of water.
The preparation method of the gentian extract comprises the following steps: pulverizing radix Gentianae 100g, adding 700mL of water, 3g of cellulase and 1g of beta-glucosidase, performing enzymolysis at 40deg.C for 3h, heating to 55deg.C, extracting for 40min, centrifuging, pouring the extractive solution into AB-8 macroporous resin, eluting with water, discharging the eluate, eluting with 70% ethanol, collecting the eluate, and concentrating.
The preparation method of the crocus sativus flower extract comprises the following steps: vacuum drying crocus sativus flower at 44deg.C for 24 hr, pulverizing, adding 1000mL water into 100g, heating to 45deg.C, extracting for 55min, centrifuging, and concentrating the extractive solution.
The preparation method of the paeonia lactiflora root extract comprises the following steps: 100g of paeonia lactiflora root powder is added with 800mL of 30% ethanol, leaching is carried out for 35min at 55 ℃, the extracting solution is poured into D-101 macroporous resin after centrifugation, water is used for eluting, and eluent is collected and concentrated to obtain the paeonia lactiflora root extract.
The preparation method of the centella asiatica extract comprises the following steps: steaming 100g centella asiatica at 100deg.C for 8min, adding 900mL absolute ethanol, leaching at 85deg.C for 100min, centrifuging, pouring the leaching solution into X-5 macroporous resin, eluting with water, collecting eluate, and concentrating.
The preparation method of the olive leaf extract comprises the following steps: drying and crushing olive leaves, weighing 100g of powder, adding 5g of beta-cyclodextrin, grinding, adding 700mL of acetone, soaking for 2 hours, centrifuging, adding 900mL of 70% ethanol into the solid residue, performing ultrasonic treatment at 330w power for 30 minutes, heating to 80 ℃ for leaching for 35 minutes, centrifuging, concentrating the extract to 1/30 of the original volume, adding into a polyamide resin column, eluting with 85% ethanol, collecting the eluent, and concentrating.
The preparation method of the composition comprises mixing radix Gentianae extract, stigma croci Sativi extract, radix Paeoniae extract, herba Centellae extract, and folium Canarii albi extract with water.
Example 2
The embodiment provides a natural plant extract composition with relieving, repairing and anti-allergic effects, which comprises 3g of gentian root extract, 5g of crocus sativus flower extract, 5g of paeonia lactiflora root extract, 2g of centella asiatica extract, 3g of olive leaf extract and 67.2g of water.
The preparation method of the gentian extract comprises the following steps: pulverizing radix Gentianae 100g, adding 600mL of water, 2g of cellulase and 1g of beta-glucosidase, performing enzymolysis at 50deg.C for 2h, extracting at 50deg.C for 60min, centrifuging, pouring the extractive solution into D-101 macroporous resin, eluting with water, discharging the eluent, eluting with 65% ethanol, collecting the eluent, and concentrating.
The preparation method of the crocus sativus flower extract comprises the following steps: vacuum drying stigma croci Sativi at 40deg.C for 30 hr, pulverizing, adding 1200mL water into 100g, heating to 40deg.C, extracting for 60min, centrifuging, and concentrating the extractive solution.
The preparation method of the paeonia lactiflora root extract comprises the following steps: 100g of paeonia lactiflora root powder is added with 900mL of 40% ethanol, leaching is carried out for 40min at 50 ℃, the extracting solution is poured into D-101 macroporous resin after centrifugation, water is used for eluting, and eluent is collected and concentrated to obtain the paeonia lactiflora root extract.
The preparation method of the centella asiatica extract comprises the following steps: steaming 100g centella asiatica at 90deg.C for 10min, adding 800mL absolute ethanol, leaching at 90deg.C for 90min, centrifuging, pouring the leaching solution into X-5 macroporous resin, eluting with water, collecting eluate, and concentrating.
The preparation method of the olive leaf extract comprises the following steps: drying and crushing olive leaves, weighing 100g of powder, adding 3g of beta-cyclodextrin, grinding, adding 800mL of acetone, soaking for 2 hours, centrifuging, adding 800mL of 80% ethanol into the solid residue, performing ultrasonic treatment at 300w power for 40min, heating to 90 ℃ for leaching for 20min, centrifuging, concentrating the extract to 1/20 of the original volume, adding into a polyamide resin column, eluting with 75% ethanol, collecting the eluent, and concentrating.
The preparation method of the composition comprises mixing radix Gentianae extract, stigma croci Sativi extract, radix Paeoniae extract, herba Centellae extract, and folium Canarii albi extract with water.
Example 3
The embodiment provides a natural plant extract composition with relieving, repairing and anti-allergic effects, which comprises 5g of gentian root extract, 3g of crocus sativus flower extract, 3g of paeonia lactiflora root extract, 4g of centella asiatica extract, 5g of olive leaf extract and 52.5g of water.
The preparation method of the gentian extract comprises the following steps: pulverizing radix Gentianae 100g, adding 800mL of water, 5g of cellulase and 1g of beta-glucosidase, performing enzymolysis at 35deg.C for 4h, heating to 60deg.C for 30min, centrifuging, pouring the extractive solution into WLD-3 macroporous resin, eluting with water, discharging the eluate, eluting with 80% ethanol, collecting eluate, and concentrating.
The preparation method of the crocus sativus flower extract comprises the following steps: vacuum drying stigma croci Sativi at 50deg.C for 20 hr, pulverizing, adding 900mL water into 100g, heating to 50deg.C, extracting for 50min, centrifuging, and concentrating the extractive solution.
The preparation method of the paeonia lactiflora root extract comprises the following steps: 100g of paeonia lactiflora root powder is added with 700mL of 20% ethanol, leaching is carried out for 30min at 60 ℃, the extracting solution is poured into D-101 macroporous resin after centrifugation, water is used for eluting, and eluent is collected and concentrated to obtain the paeonia lactiflora root extract.
The preparation method of the centella asiatica extract comprises the following steps: steaming 100g centella asiatica at 100deg.C for 5min, adding 1000mL absolute ethanol, leaching at 80deg.C for 120min, centrifuging, pouring the leaching solution into X-5 macroporous resin, eluting with water, collecting eluate, and concentrating.
The preparation method of the olive leaf extract comprises the following steps: drying and crushing olive leaves, weighing 100g of powder, adding 7g of beta-cyclodextrin, grinding, adding 500mL of acetone, soaking for 2 hours, centrifuging, adding 1000mL of 60% ethanol into the solid residue, performing ultrasonic treatment at 350w power for 20 minutes, heating to 90 ℃ for leaching for 20 minutes, centrifuging, concentrating the extract to 1/40 of the original volume, adding into a polyamide resin column, eluting with 95% ethanol, collecting the eluent, and concentrating.
The preparation method of the composition comprises mixing radix Gentianae extract, stigma croci Sativi extract, radix Paeoniae extract, herba Centellae extract, and folium Canarii albi extract with water.
Example 4
The present example provides a natural plant extract composition having soothing, repairing and anti-allergic effects, which is different from example 1 only in that the gentian extract preparation process is only enzymatically hydrolyzed using cellulase.
Example 5
This example provides a natural plant extract composition with soothing, repairing, anti-sensitization effects, which is different from example 1 only in that the olive leaf extract preparation process is not subjected to the beta-cyclodextrin embedding process, and the crushed olive leaf powder is directly added into acetone.
Comparative example 1
This example provides a natural plant extract composition having soothing, repairing, and anti-allergic effects, which is different from example 1 only in that centella asiatica extract is used instead of paeonia lactiflora root extract.
Comparative example 2
This example provides a natural plant extract composition having soothing, repairing, anti-sensitization effects, which is different from example 1 only in that centella asiatica extract is used instead of gentian root extract.
Comparative example 3
The present example provides a natural plant extract composition having soothing, repairing, and anti-allergic effects, which is different from example 1 only in that centella asiatica extract is used instead of paeonia radix and gentian radix extract.
Comparative example 4
This example provides a natural plant extract composition with soothing, repairing, and anti-sensitization effects, which is different from example 1 only in that paeonia lactiflora root extract is used instead of olive leaf extract.
Comparative example 5
This example provides a natural plant extract composition with soothing, repairing, and anti-allergic effects, which is different from example 1 only in that paeonia radix extract is used instead of crocus sativus flower extract.
Comparative example 6
This example provides a natural plant extract composition with soothing, repairing, anti-allergic effects, which is different from example 1 only in that paeonia radix extract is used instead of olive leaf and crocus sativus flower extracts.
Experimental example 1
The effect of the plant extract compositions of examples 1-5, comparative examples 1-6 on the histamine release and the expression of pro-inflammatory cytokines by KU812 cells was examined as follows:
preparing and treating a tested sample: 1mg of the plant extract composition of examples 1 to 5, comparative examples 1 to 6, respectively, was dissolved with 10mL of LDMSO, and diluted to a concentration of 0.05mg/mL in IMDM medium of 10% fetal bovine serum.
Cell culture and model establishment: cell density was diluted to 2.2X10 with IMDM medium containing 10% fetal bovine serum 6 Each mL was then plated in 96-well plates at an inoculum size of 180. Mu.L per well.
Grouping and processing: the method comprises the steps of dividing the experimental group, the model control group, the blank control group and setting 3 parallel groups in each group; wherein 20. Mu.L of the test sample (examples 1-5, comparative examples 1-6) was added to each of the experimental groups, 20. Mu.L of IMDM culture solution containing 10% fetal bovine serum was added to each of the blank control group and the model control group, and the mixture was placed at 37℃and 5% CO 2 After incubation in the incubator for 2h, 40nM crotyl alcohol-12-tetradecanoate-13-acetate (PMA) 5. Mu.L and 1. Mu.M calcium ionophore (A23187) 5. Mu.L were added to the experimental and model control groups, respectively; the blank group was added with 10. Mu.L of DMSO.
And (3) index detection: after 2h, the cells were centrifuged, and the cell supernatant was collected, and the content of histamine and IL-1α in the supernatant was measured according to ELISA detection kit (manufacturer, wuhan Aidi Biotechnology Co., ltd., product numbers AD20844 and AD 20077), and the content of histamine and IL-1α in the hollow white control group was significantly lower than that in the model control group, indicating that the modeling was successful.
Histamine release inhibition (%) = (model group histamine content-experimental group histamine content)/model group histamine content x 100%;
inhibition rate of IL-1α release (%) = (model group IL-1α content-experimental group IL-1α content)/model group IL-1α content; the results of the histamine release inhibition and IL-1. Alpha. Release inhibition of each group are shown in Table 1.
TABLE 1 Effect of different plant extract compositions on histamine release and IL-1 alpha release from KU812 cells
The data in Table 1 show that the plant extract composition provided by the embodiment of the invention can obviously inhibit the release of histamine and IL-1 alpha from KU812 cells, and the composition can effectively inhibit the release of inflammation and histamine, thereby improving the state of allergic skin. In comparative example 1, paeonia root extract was omitted, in comparative example 2, gentian root extract was omitted, in comparative example 3, paeonia root and gentian root extract were simultaneously omitted, the above 3 groups were equivalent in inhibiting the release of inflammatory factor IL-1α and significantly reduced compared to example 1, demonstrating the synergistic effect of inhibiting the release of inflammatory factor among gentian root extract, paeonia root extract and centella asiatica extract. Similarly, comparative example 4 omitted olive leaf extract, comparative example 5 omitted crocus sativus flower extract, comparative example 6 omitted olive leaf and crocus sativus flower extract, and the above 3 were equivalent in inhibiting histamine release and significantly lower than example 1, demonstrating that the synergistic inhibition of histamine release in vivo between olive leaf extract, crocus sativus flower extract and paeonia lactiflora root extract, reduced skin allergy.
Experimental example 2
The actual application effect of examples 1-5 was examined, and the compositions of examples 1-5 were applied to the preparation of creams with an addition of 5%, the composition of the specific creams being: 1 part of cetyl alcohol, 2 parts of glyceryl monostearate, 0.5 part of sodium carboxymethyl cellulose, 0.5 part of sodium alginate, 6 parts of glycerin, 0.5 part of sorbitol, 1 part of butanediol, 0.5 part of triethanolamine, 0.05 part of citric acid, 0.05 part of disodium EDTA, 4.5 parts of natural plant extract composition with effects of relieving, repairing and resisting allergy and 70 parts of deionized water.
The preparation method of the facial cream mask comprises the following steps: heating cetyl alcohol, glyceryl monostearate, sodium carboxymethylcellulose, sodium alginate, glycerol, sorbitol, propylene glycol, triethanolamine, citric acid, EDTA disodium with deionized water to 40deg.C, stirring thoroughly, cooling to room temperature after all substances are dissolved, adding natural plant extract composition with effects of relieving, repairing and resisting sensitization, and stirring uniformly.
Through questionnaires, 100 people of the sensitive skin are selected and randomly divided into 5 groups, and the face cream prepared by the compositions of examples 1-5 is used for investigation, and is used once every person after cleansing the face every morning and evening every day, without using any other skin care products and cosmetics, and is continuously used for 4 weeks. The extent of improvement of skin problems was self-assessed after 4 weeks using a questionnaire, scoring criteria were as follows:
4, the following steps: the symptoms such as red blood streak, redness, stinging, dryness, itching and the like are well repaired;
3, the method comprises the following steps: the symptoms of red blood streak, redness, stinging, dryness, itching and the like are obviously improved;
2, the method comprises the following steps: the symptoms of red blood streak, redness, stinging, dryness, itching and the like are slightly improved;
1, the method comprises the following steps: the symptoms such as red blood streak, redness, stinging, dryness, itching and the like are not improved;
0 point: symptoms such as red blood streak, redness, stinging, dryness, itching and the like are not improved or even more serious.
TABLE 2 Effect of Using creams prepared from the compositions of examples 1-5
| Score average | |
| Example 1 | 3.9 |
| Example 2 | 3.6 |
| Example 3 | 3.55 |
| Example 4 | 3.3 |
| Example 5 | 3.2 |
The data in Table 2 show that the natural plant extract composition provided by the invention can be applied to face cream, can effectively repair symptoms such as red blood streak, redness, stinging, dryness, itching and the like, and has good effects of relieving, repairing and resisting sensitization.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (5)
1. The natural plant extract composition with the effects of relieving, repairing and resisting allergy is characterized by comprising the following components in parts by weight: 3-5 parts of gentian root extract, 3-5 parts of crocus sativus flower extract, 3-5 parts of paeonia lactiflora root extract, 2-4 parts of centella asiatica extract and 3-5 parts of olive leaf extract;
the preparation method of the gentian extract comprises the following steps: pulverizing radix Gentianae, adding water and enzyme for enzymolysis, heating for extraction, pouring the extractive solution into macroporous resin, eluting with water, discharging the eluate, eluting with ethanol, collecting the eluate, and concentrating; the enzymes are cellulase and beta-glucosidase with the mass ratio of 2-5:1; the macroporous resin is one or more selected from AB-8, XAD-2, D-101 and WLD-3;
the preparation method of the crocus sativus flower extract comprises the following steps: drying stigma croci Sativi, pulverizing, extracting with water, and concentrating the extractive solution;
the preparation method of the paeonia lactiflora root extract comprises the following steps: extracting radix Paeoniae powder with ethanol, pouring the extractive solution into D-101 macroporous resin, eluting with water, collecting eluate, and concentrating;
the preparation method of the centella asiatica extract comprises the following steps: steaming herba Centellae, extracting with absolute ethanol, pouring the extractive solution into X-5 macroporous resin, eluting with water, collecting eluate, and concentrating;
the preparation method of the olive leaf extract comprises the following steps: drying and pulverizing olive leaf, adding beta-cyclodextrin, grinding, soaking in acetone, separating solid from liquid, adding ethanol into the solid residue, ultrasonic extracting, concentrating the extractive solution, adding into polyamide resin, eluting with ethanol, and concentrating the eluate.
2. The natural plant extract composition according to claim 1, which is composed of the following components in parts by weight: 4 parts of gentian root extract, 4 parts of crocus sativus flower extract, 4 parts of paeonia lactiflora root extract, 3 parts of centella asiatica extract and 4 parts of olive leaf extract.
3. A process for the preparation of a natural plant extract composition according to any one of claims 1 to 2, characterized by comprising the steps of: and uniformly mixing the raw materials to obtain the composition.
4. A skin care product with soothing, repairing and anti-allergic effects, which is characterized by comprising the composition according to any one of claims 1-2 and auxiliary materials in the field of cosmetics.
5. The skin care product according to claim 4, wherein the composition is added to the skin care product in an amount of 3 to 8wt%.
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| EP1604647A1 (en) * | 2004-05-12 | 2005-12-14 | Ichimaru Pharcos Co., Ltd. | Cosmetic composition containing polyorganosiloxane-containing epsilon-polylysine polymer, and polyhydric alcohol, and production thereof |
| CN106456530A (en) * | 2014-05-16 | 2017-02-22 | 雷斯托尔西有限公司 | Biphasic cosmetic |
| CN111001013A (en) * | 2019-12-12 | 2020-04-14 | 安徽工业大学 | Loquat leaf extract nano capsule, preparation method and application |
| CN111329808A (en) * | 2020-04-03 | 2020-06-26 | 西安力邦医美科技有限公司 | Cosmetic composition with anti-glycosylation and anti-aging effects and application thereof |
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