CN109568181B - Tea oil hand cream - Google Patents
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention provides tea oil hand cream which mainly comprises the following components in percentage by mass: 5-10% of glycerol, 5-10% of mineral oil, 3-6% of caprylic/capric triglyceride, 1-3% of cyclopentadimethylsiloxane, 1-3% of hydroxyethyl urea, 1-3% of cetearyl alcohol, 0.5-1.5% of cetearyl glucoside, 0.1-1% of beeswax, 0.1-1% of liquid paraffin, 0.1-1% of cetyl alcohol, 0.1-1% of stearyl alcohol, 0.05-0.25% of polyacrylamide, 0.05-0.25% of C13-14 isoparaffin, 0.05-0.25% of laureth-70.05, 0.1-0.3% of carbomer, 0.05-0.15% of xanthan gum, 0.1-0.3% of triethanolamine, 0.01-0.1% of allantoin, 0.01-0.1% of salicylic acid, 0.1-0.5% of phenoxyethanol, 0.1-0.3% of methylparaben, 0.1-0.2% of ethylparaben, 0.05-0.15% of ethylhexyl glycerol, 0.5-5% of fermented camellia seed oil and 53-80% of water; the fermented camellia seed oil is prepared from the following raw materials: camellia seed cake, camellia root and camellia oleifera leaf. The hand cream disclosed by the invention is easy to absorb through skin, and can achieve good skin care effects of preventing frost cracking, preventing rough skin, preventing dry cracking, moistening and tendering skin, relieving itching and relieving pain.
Description
Technical Field
The invention relates to the field of cosmetics, and in particular relates to tea oil hand cream.
Background
The camellia seed Oil is fatty Oil obtained from mature seeds of camellia oleifera or camellia oleifera (Oil-tea camellia) of the camellia family by Oil extraction technical methods such as a squeezing method and a leaching method, contains rich unsaturated fatty Oil, mainly contains unsaturated fatty acid mainly comprising oleic acid and linoleic acid, and also contains vitamin E and antioxidant components, and is recorded in the compendium of materia medica: the camellia seed oil is cold and cool in nature and sweet and flat in taste, and has the effects of relaxing bowel, clearing heat and eliminating dampness, moistening lung and eliminating phlegm, and benefiting head and eyes. The whole body of the oil tea tree is precious, oil tea seed oil contains high-content unsaturated fatty acid, tocopherol and squalene as well as unique tea polyphenol, oil tea glycoside, oil tea saponin and other physiological active substances, and has good skin care application prospects of oxidation resistance, radiation protection, water locking and moisture retention, bacteriostasis, inflammation resistance and hair nourishing; the camellia oleifera flower is also high in medicinal value and has the curative effects of astringing, stopping bleeding, cooling blood, regulating stomach, regulating qi, dissipating blood stasis, reducing swelling and the like; the oil tea also contains tea polyphenol and caffeine, has important physiological activity to human body, has high medicinal value and strong oxidation resistance, and can promote metabolism of human body; the oil tea root has the efficacies of removing blood stasis, reducing swelling and promoting digestion on the aspect of medicinal value.
At present, the oil tea seed oil is obtained mainly by adopting a mode of firstly squeezing and then refining. However, the residual oil content after oil extraction from oil-tea camellia seeds by the traditional squeezing method is as high as 5-10%, and the oil cannot be effectively utilized (reference document [1] He Zhe Hua, Shuyunlin, Dingde root, Zhanrenchun, Jiang Shujun, Liu Huan Juan, Xiejing Lin, Yu Hu Ming, Yulin, 3 processes for preparing oil-tea camellia seeds, the acid value and peroxide value of the oil-tea camellia seeds, and the comparison of benzo [ a ] pyrene [ J ]. Zhejiang agricultural science, 2018,59(06):1001 and 1006 ]).
Chapped hands are a common skin problem which is easy to occur in autumn and winter, and are mainly characterized by dry skin, cornification, thickening, hypoelasticity, desquamation, chapping and the like, and even accompanied by different degrees of pain and itching. The main problems of the method are that the air is cold and dry in autumn and winter, the external humidity is low, the palm skin is not secreted by sebaceous glands to cause low moistening degree and dry skin, and the skin is chapped due to walking movement and external force traction in daily life. Chapped skin gradually becomes cornified due to the fact that effective maintenance cannot be achieved, as chapped parts spread to dermis and subcutaneous tissues, chapped areas of epidermis are enlarged, cornification is deepened, and some of the chapped parts are also accompanied by microbial infection, bleeding and pain of chapped parts of serious patients affect daily work and life. However, most of the hand creams sold in the market at present have slow curative effect and are difficult to cure radically.
Disclosure of Invention
Based on the above, the invention aims to provide the tea oil hand cream which has the effects of preventing frost crack, rough skin, dry crack, skin tendering, pruritus and pain and the like.
In order to solve the technical problems, the invention is realized by the following technical scheme:
a hand cream mainly comprises the following components in percentage by mass: 5-10% of glycerol, 5-10% of mineral oil, 3-6% of caprylic/capric triglyceride, 1-3% of cyclopentadimethylsiloxane, 1-3% of hydroxyethyl urea, 1-3% of cetearyl alcohol, 0.5-1.5% of cetearyl glucoside, 0.1-1% of beeswax, 0.1-1% of liquid paraffin, 0.1-1% of cetyl alcohol, 0.1-1% of stearyl alcohol, 0.05-0.25% of polyacrylamide, 0.05-0.25% of C13-14 isoparaffin, 0.05-0.25% of laureth-70.05, 0.1-0.3% of carbomer, 0.05-0.15% of xanthan gum, 0.1-0.3% of triethanolamine, 0.01-0.1% of allantoin, 0.01-0.1% of salicylic acid, 0.1-0.5% of phenoxyethanol, 0.1-0.3% of methylparaben, 0.1-0.2% of ethylparaben, 0.05-0.15% of ethylhexyl glycerol, 0.5-5% of fermented camellia seed oil and 53-80% of water; the fermented camellia seed oil is prepared from the following raw materials: camellia seed cake, camellia root and camellia oleifera leaf.
In some embodiments, the fermented camellia oleosa seed oil is prepared from the following raw materials: 1000 parts of camellia seed cake, 1-10 parts of camellia root and 1-10 parts of camellia tea.
In some embodiments, the preparation method of the fermented camellia oleosa seed oil comprises the following steps:
drying oil tea roots and oil tea leaves in the shade, mixing the dried oil tea roots and the oil tea leaves with oil tea seed cakes, crushing the oil tea roots and the oil tea seed cakes, adding water to prepare a solution with the weight percent of 10-20, and adjusting the pH value to 3.5-5.0; sterilizing at high temperature, and cooling to room temperature to obtain sterilized mixture;
step two, inoculating microzyme into a liquid culture medium for amplification culture to obtain mature strains; inoculating mature strains into the sterilized mixture for fermentation to obtain fermentation liquor;
adding pectinase and cellulase into the fermentation liquor, uniformly stirring, adjusting the temperature to 30-60 ℃, and reacting for 1-2 hours; then heating and demulsifying; centrifuging by a centrifuge, and collecting the upper layer vegetable oil.
In some of these embodiments, the pulverizing of step one is to 10-50 mesh.
In some embodiments, the autoclaving in step one is: sterilizing at 100-120 deg.C for 10-20 min.
The liquid culture medium in the second step of the invention is a culture medium suitable for the growth and propagation of yeast.
In some embodiments, the liquid medium is YPD medium and the expansion culture is performed at 30-40 deg.C for 1-3 days.
In some embodiments, the yeast in step two is a mixture of saccharomyces cerevisiae and candida, the inoculation amount of the yeast is 6-9wt% of the weight of the culture medium, and the addition ratio of the saccharomyces cerevisiae to the candida is 1 (5-10).
In some of these embodiments, the amount of inoculated mature bacteria used in step two is 5-10wt% of the weight of the sterilized mixture, and the fermentation conditions are: fermenting at 25-35 deg.C with ventilation of 1-4VVM for 1-3 days.
In some embodiments, the addition amount of the pectinase and the cellulase in the step three is 10-100U/mL.
In some embodiments, the temperature-raising demulsification in the third step is temperature-raising to 80-85 ℃ for demulsification treatment for 10-30 minutes, and the centrifugation is 1000-5000rpm for 10-30 minutes.
The invention has the following advantages and beneficial effects:
1. the fermented camellia seed oil disclosed by the invention fully utilizes the waste camellia seed cake after the camellia seed oil is squeezed, is obtained by adopting microbial fermentation and enzymolysis auxiliary treatment, and is beneficial to promoting the environmental protection career of energy conservation, emission reduction and waste utilization.
2. The camellia oleifera root and the camellia oleifera leaf are added in the preparation process of the fermented camellia seed oil, the effective active components of fat-soluble macromolecules which are difficult to absorb by human skin and contained in the raw materials are decomposed into micromolecules which are easy to absorb through the action of microorganisms through microbial fermentation treatment, the obtained fermented camellia seed oil becomes functional grease with the skin care effect, and the skin care effect of preventing frost crack, rough skin, dry crack, moistening and tendering skin, itching and pain can be achieved by adding the fermented camellia seed oil into hand cream.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below. However, the embodiments of the present invention are not limited thereto, and the process parameters or conditions not particularly mentioned may be performed by referring to the conventional techniques.
The camellia seed cake provided by the invention is a residue cake obtained after oil pressing of camellia seeds.
Example 1
A fermented oil tea seed oil is prepared by the following steps:
step one, mixing 10g of dried oil tea roots and 100g of dried oil tea leaves with 1000g of oil tea seed cakes, and crushing to 10 meshes; adding water to prepare a 10wt% solution, and adjusting the pH value to 5.0; sterilizing at 120 deg.C for 10 min, and cooling to room temperature to obtain sterilized mixture;
step two, respectively inoculating saccharomyces cerevisiae and candida to a YPD culture medium, culturing for 1-3 days at 30-40 ℃ to obtain mature saccharomyces cerevisiae strains and candida strains, wherein the strain content of the saccharomyces cerevisiae strains and the candida strains is controlled to be 1 multiplied by 106-1×108cfU/mL; mixing the saccharomyces cerevisiae strain and the candida strain according to the proportion of 1 (5-10) to obtain a mixed strain, and then inoculating the mixed strain into a sterilized mixture for fermentation, wherein the inoculation amount of the mixed strain is 6-9wt% of the weight of a culture medium, and the fermentation condition is that the mixed strain is fermented for 1-3 days under the conditions of 25-35 ℃ and the ventilation volume of 1-4 VVM; obtaining fermentation liquor;
adding pectinase and cellulase into the fermentation liquor, wherein the addition amount of the pectinase is 10U/mL, and the addition amount of the cellulase is 100U/mL; stirring uniformly, adjusting the temperature to 60 ℃, and reacting for 1 hour; then heating to 80 ℃ for demulsification treatment for 30 minutes; centrifuging for 30 minutes by a centrifuge with the speed of 1000rpm, and collecting the upper layer vegetable oil.
Example 2
A fermented oil tea seed oil is prepared by the following steps:
step one, mixing 10g of dried oil tea roots and 1g of dried oil tea leaves with 1000g of oil tea seed cakes, and crushing to 50 meshes; adding water to prepare a 20wt% solution, and adjusting the pH value to 3.5; sterilizing at 100 deg.C for 20 min, and cooling to room temperature to obtain sterilized mixture;
step two, inoculating 9wt% of saccharomyces cerevisiae and candida in the liquid YPD culture medium, wherein the addition ratio of the saccharomyces cerevisiae to the candida is 1: 10; ventilating and enlarging culturing at 30 deg.C for 3 days to obtain mature strain; inoculating 10wt% of mature strain into the sterilized mixture; fermenting at 25 deg.C and ventilation of 1VVM for 1 day to obtain fermentation liquid;
adding pectinase and cellulase into the fermentation liquor, wherein the addition amount of the pectinase is 100U/mL, and the addition amount of the cellulase is 10U/mL; stirring uniformly, adjusting the temperature to 30 ℃, and reacting for 2 hours; then heating to 85 ℃ for demulsification treatment for 10 minutes; centrifuging at 5000rpm for 10 min, and collecting the upper layer vegetable oil.
Example 3
A fermented oil tea seed oil is prepared by the following steps:
firstly, mixing 5g of oil-tea camellia root and 5g of oil-tea camellia leaf which are dried in the shade with 550g of oil-tea camellia seed cake, and crushing to 30 meshes; adding water to prepare a 15 wt% solution, and adjusting the pH value to 4.2; sterilizing at 110 deg.C for 15 min, and cooling to room temperature to obtain sterilized mixture;
step two, inoculating 7.5 wt% of saccharomyces cerevisiae and candida in the liquid YPD culture medium, and performing aeration amplification culture at 35 ℃ for 2 days to obtain mature strains, wherein the addition ratio of the saccharomyces cerevisiae to the candida is 1: 7.5; inoculating 7.5 wt% of mature strain into the sterilized mixture; fermenting at 30 deg.C and ventilation of 2.5VVM for 2 days to obtain fermentation liquid;
adding pectinase and cellulase into the fermentation liquor, wherein the addition amount of the pectinase is 55U/mL, and the addition amount of the cellulase is 55U/mL; stirring uniformly, adjusting the temperature to 45 ℃, and reacting for 1.5 hours; then heating to 83 ℃ for demulsification treatment for 20 minutes; centrifuging at 3000rpm for 20 min, and collecting the upper layer vegetable oil.
Comparative example 1
A fermented oil tea seed oil is prepared by the following steps:
step one, 10g of dried oil tea root is mixed with 550g of oil tea seed cake and crushed to 30 meshes; adding water to prepare a 15 wt% solution, and adjusting the pH value to 4.2; sterilizing at 110 deg.C for 15 min, and cooling to room temperature to obtain sterilized mixture;
step two, inoculating 7.5 wt% of saccharomyces cerevisiae and candida in the liquid YPD culture medium, and performing aeration amplification culture at 35 ℃ for 2 days to obtain mature strains, wherein the addition ratio of the saccharomyces cerevisiae to the candida is 1: 7.5; inoculating 7.5 wt% of mature strain into the sterilized mixture; fermenting at 30 deg.C and ventilation of 2.5VVM for 2 days to obtain fermentation liquid;
adding pectinase and cellulase into the fermentation liquor, wherein the addition amount of the pectinase is 55U/mL, and the addition amount of the cellulase is 55U/mL; stirring uniformly, adjusting the temperature to 45 ℃, and reacting for 1.5 hours; then heating to 83 ℃ for demulsification treatment for 20 minutes; centrifuging at 3000rpm for 20 min, and collecting the upper layer vegetable oil.
Comparative example 2
A fermented oil tea seed oil is prepared by the following steps:
step one, 10g of dried tea-oil tree leaves in the shade are mixed with 550g of tea-oil tree seed cakes and crushed to 30 meshes; adding water to prepare a 15 wt% solution, and adjusting the pH value to 4.2; sterilizing at 110 deg.C for 15 min, and cooling to room temperature to obtain sterilized mixture;
step two, inoculating 7.5 wt% of saccharomyces cerevisiae and candida in the liquid YPD culture medium, and performing aeration amplification culture at 35 ℃ for 2 days to obtain mature strains, wherein the addition ratio of the saccharomyces cerevisiae to the candida is 1: 7.5; inoculating 7.5 wt% of mature strain into the sterilized mixture; fermenting at 30 deg.C and ventilation of 2.5VVM for 2 days to obtain fermentation liquid;
adding pectinase and cellulase into the fermentation liquor, wherein the addition amount of the pectinase is 55U/mL, and the addition amount of the cellulase is 55U/mL; stirring uniformly, adjusting the temperature to 45 ℃, and reacting for 1.5 hours; then heating to 83 ℃ for demulsification treatment for 20 minutes; centrifuging at 3000rpm for 20 min, and collecting the upper layer vegetable oil.
Comparative example 3
A fermented oil tea seed oil is prepared by the following steps:
firstly, crushing 550g of camellia seed cake to 30 meshes; adding water to prepare a 15 wt% solution, and adjusting the pH value to 4.2; sterilizing at 110 deg.C for 15 min, and cooling to room temperature to obtain sterilized mixture;
step two, inoculating 7.5 wt% of saccharomyces cerevisiae and candida in the liquid YPD culture medium, and performing aeration amplification culture at 35 ℃ for 2 days to obtain mature strains, wherein the addition ratio of the saccharomyces cerevisiae to the candida is 1: 7.5; inoculating 7.5 wt% of mature strain into the sterilized mixture; fermenting at 30 deg.C and ventilation of 2.5VVM for 2 days to obtain fermentation liquid;
adding pectinase and cellulase into the fermentation liquor, wherein the addition amount of the pectinase is 55U/mL, and the addition amount of the cellulase is 55U/mL; stirring uniformly, adjusting the temperature to 45 ℃, and reacting for 1.5 hours; then heating to 83 ℃ for demulsification treatment for 20 minutes; centrifuging at 3000rpm for 20 min, and collecting the upper layer vegetable oil.
Comparative example 4
A fermented oil tea seed oil is prepared by the following steps:
firstly, mixing 5g of oil-tea camellia root and 5g of oil-tea camellia leaf which are dried in the shade with 550g of oil-tea camellia seed cake, and crushing to 30 meshes; adding water to prepare a 15 wt% solution, and adjusting the pH value to 4.2; sterilizing at 110 deg.C for 15 min, and cooling to room temperature to obtain sterilized mixture;
step two, inoculating 7.5 wt% of saccharomyces cerevisiae into the liquid YPD culture medium, and performing aeration amplification culture at 35 ℃ for 2 days to obtain mature strains; inoculating 7.5 wt% of mature strain into the sterilized mixture; fermenting at 30 deg.C and ventilation of 2.5VVM for 2 days to obtain fermentation liquid;
adding pectinase and cellulase into the fermentation liquor, wherein the addition amount of the pectinase is 55U/mL, and the addition amount of the cellulase is 55U/mL; stirring uniformly, adjusting the temperature to 45 ℃, and reacting for 1.5 hours; then heating to 83 ℃ for demulsification treatment for 20 minutes; centrifuging at 3000rpm for 20 min, and collecting the upper layer vegetable oil.
Comparative example 5
A fermented oil tea seed oil is prepared by the following steps:
firstly, mixing 5g of oil-tea camellia root and 5g of oil-tea camellia leaf which are dried in the shade with 550g of oil-tea camellia seed cake, and crushing to 30 meshes; adding water to prepare a 15 wt% solution, and adjusting the pH value to 4.2; sterilizing at 110 deg.C for 15 min, and cooling to room temperature to obtain sterilized mixture;
step two, inoculating 7.5 wt% of candida in the liquid YPD culture medium, and performing aeration amplification culture at 35 ℃ for 2 days to obtain mature strains, wherein the addition ratio of saccharomyces cerevisiae to candida is 1: 7.5; inoculating 7.5 wt% of mature strain into the sterilized mixture; fermenting at 30 deg.C and ventilation of 2.5VVM for 2 days to obtain fermentation liquid;
adding pectinase and cellulase into the fermentation liquor, wherein the addition amount of the pectinase is 55U/mL, and the addition amount of the cellulase is 55U/mL; stirring uniformly, adjusting the temperature to 45 ℃, and reacting for 1.5 hours; then heating to 83 ℃ for demulsification treatment for 20 minutes; centrifuging at 3000rpm for 20 min, and collecting the upper layer vegetable oil.
Experiment 2 trial for population
Experimental and control groups 1 to 3 and 1 to 5 of hand cream having the compositions shown in table 1 were prepared, and the hand cream was composed of the following components in percentage by mass:
TABLE 1 hand cream test groups 1-3 and control groups 1-5
Experimental method 1: test for patients with frost cracks in their hand skin
1. Test subjects: there were 240 volunteers with frost-cracks in the skin of the hands, 175 men and 65 women. Volunteers were randomly divided into 8 groups of 30 individuals.
2. Sample preparation: hand cream samples from experimental groups 1-3 and control groups 1-5.
3. The using method comprises the following steps: experimental groups: after the hands are cleaned by warm water for 5 minutes and dried, samples prepared by the hand cream experimental groups 1-3 prepared by the invention are smeared, 2 times a day, once in the morning and evening, and the using amount of each time is 0.1g/10cm2. Control group: samples were prepared by applying control groups 1-5, and the application method, dosage and frequency were the same as those of the treatment groups.
4. And (4) judging the standard:
(1) the effect is shown: the skin at the frost crack part of the hand skin is completely healed without scars, the skin becomes tender and moist, and the pain feeling disappears;
(2) the method has the following advantages: the frost crack basically heals with slight trace, and relieves pain symptoms;
(3) and (4) invalidation: the symptoms are not obviously improved.
The data after the test is recorded, the less the number of days for the affected part to completely recover, and the more the number of recovered people in the same time, the better the drug effect. Test results of 5 days and 10 days are tested: see table 2.
Table 2 frost crack effect test statistical table
As can be seen from the data recorded in the table above, after the hand cream experimental group 1-3 prepared by the invention is used for smearing hands, the hand cream experimental group has remarkable effects except for 2 people in the hand cream experimental group 1, the hand skin is completely healed, the skin becomes tender and white, the hand cream is moist, and the pain feeling disappears.
As can be seen from the comparison between the hand cream experimental groups 1-3 and the control groups 1-2, when the oil tea root or the oil tea leaves are absent in the fermented oil tea seed oil, the skin care effect is poor (15 cases are still ineffective after 10 days using the sample of the control group 1, and 15 cases are still ineffective after 10 days using the sample of the control group 2). After 10 days, 20 of the samples prepared by the control group 3 are still ineffective, and the effect is not ideal. Therefore, the fermented camellia seed oil prepared by compounding the camellia seed cake, the camellia root and the camellia leaves through fermentation has better effect and has synergistic effect.
Compared with the control group 4-5, the hand cream experimental group 1-3 has better anti-cracking effect on the fermented camellia oleosa seed oil obtained by the mixed fermentation of saccharomyces cerevisiae and candida. The anti-freezing effect of the fermented camellia oleosa seed oil obtained by fermenting with saccharomyces cerevisiae or candida alone is poor, 22 cases of the samples are still ineffective after the samples of the control group 4 are used for 10 days, and 22 cases of the samples of the control group 5 are still ineffective after the samples of the control group 5 are used for 10 days.
Experimental method 2: tests on patients with rough, itchy, and dry hand skin
1. Test subjects: 240 volunteers with rough and itching hand and dry skin, 115 men and 125 women. Volunteers were randomly divided into 8 groups of 30 individuals.
2. Sample preparation: hand cream samples from experimental groups 1-3 and control groups 1-5.
3. The using method comprises the following steps: the prepared sample is applied to hand 2 times a day, once in the morning and at night, and the dosage of each time is 0.1g/10cm2。
4. Testing
4.1 moisturizing Effect test
The test method comprises the following steps: after the subject smears the test specimen for 15 minutes, the moisture content of the back of the hand is then measured in an environment where the test environment temperature is 25 ℃ and the relative humidity is 60%. A1 square experimental area of 2CM multiplied by 2CM is marked on the back of a hand to be used as a test area of a sample, and a Corneometer CM825 probe of a multifunctional skin tester is used for testing the moisture content of the skin, the probe reflects the change of the moisture of the skin by measuring the capacitance value of the skin, and the higher the CM value is, the higher the moisture content of the stratum corneum is. The multifunctional skin tester respectively measures the moisture content of the skin of the hand 2 and 4 hours before and after the hand cream is applied, and records the result. The specific results are shown in Table 3.
Table 3 moisturizing test results table
Test results show that the hand cream experimental groups 1-3 have obvious moisturizing effect on skin (the CM value is increased to 71.32-72.41 after 2 hours of use and is 64.56-65.67 after 4 hours) and the moisturizing effect is better than that of the control groups 1-5 (the CM value is increased to 50.34-55.35 after 2 hours of use and is 38.56-41.31 after 4 hours of use and is increased to the original CM value). With the time being prolonged, the moisture loss is slower and the moisturizing capability is more durable after the hand cream experimental groups 1-3 are used.
4.2 test of moistening and tendering effects
And (4) judging the standard:
(1) the effect is shown: the chapping symptom disappears, no desquamation and no scale are generated, the skin becomes tender, moist and elastic, and the itch disappears;
(2) the method has the following advantages: the chapped part is basically healed, and has slight trace, rough symptom and pruritus symptom relief;
(3) and (4) invalidation: the symptoms are not obviously improved.
The data after the test are recorded, the less days are taken for the symptoms to completely disappear, and the more the number of people recovered in the same time, the better the drug effect is. Trial results of 3 days and 7 days are as follows: see table 4.
Table 4 test statistical table for moistening and tendering effect
The data recorded in the table above show that the hand cream experimental group 1-3 prepared by the invention has remarkable effect except 1 person in the hand cream experimental group 1 after being applied for 7 days, the hand skin has no chapping symptom, no desquamation and no scale, the skin becomes tender, moist and elastic, and the itch disappears.
Compared with the control group 1-5, the hand cream experimental group 1-3 shows that the fermented camellia seed oil obtained by compounding the camellia seed cake, the camellia root and the camellia oleifera leaf and fermenting and hydrolyzing by the preparation method has better skin care effect and synergistic effect.
Statistics, detection and analysis of the test subjects using the hand cream samples prepared by the experimental groups 1-3 show that the hand cream prepared by the invention has no stimulation to skin, no toxic or side effect, has the functions of diminishing inflammation and sterilizing for frost crack and dry crack skin, has the functions of accelerating wound healing of damaged skin, promoting skin metabolism, promoting blood circulation and removing obstruction in channels, enables the skin to be tender, white and elastic, has the function of moistening dry skin, and has the function of 95 percent peeling
The phenomenon disappeared and the scaling symptom was completely removed.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention will still fall within the scope of the technical solution of the present invention without departing from the content of the technical solution of the present invention.
Claims (6)
1. The hand cream is characterized by mainly comprising the following components in percentage by mass: 5-10% of glycerol, 5-10% of mineral oil, 3-6% of caprylic/capric triglyceride, 1-3% of cyclopentadimethylsiloxane, 1-3% of hydroxyethyl urea, 1-3% of cetearyl alcohol, 0.5-1.5% of cetearyl glucoside, 0.1-1% of beeswax, 0.1-1% of liquid paraffin, 0.1-1% of cetyl alcohol, 0.1-1% of stearyl alcohol, 0.05-0.25% of polyacrylamide, 0.05-0.25% of C13-14 isoparaffin, 0.05-0.25% of laureth-70.05, 0.1-0.3% of carbomer, 0.05-0.15% of xanthan gum, 0.1-0.3% of triethanolamine, 0.01-0.1% of allantoin, 0.01-0.1% of salicylic acid, 0.1-0.5% of phenoxyethanol, 0.1-0.3% of methylparaben, 0.1-0.2% of ethylparaben, 0.05-0.15% of ethylhexyl glycerol, 0.5-5% of fermented camellia seed oil and 53-80% of water; the fermented camellia seed oil is prepared from the following raw materials: 1000 parts of camellia seed cake, 1-10 parts of camellia root and 1-10 parts of camellia tea;
the preparation method of the fermented camellia seed oil comprises the following steps:
drying oil tea roots and oil tea leaves in the shade, mixing the dried oil tea roots and the oil tea leaves with oil tea seed cakes, crushing the oil tea roots and the oil tea seed cakes, adding water to prepare a solution with the weight percent of 10-20, and adjusting the pH value to 3.5-5.0; the high-temperature sterilization temperature is as follows: cooling to room temperature at 100-120 ℃ to obtain a sterilized mixture;
step two, inoculating microzyme into a liquid culture medium for enlarged culture to obtain mature strains, wherein the microzyme is the mixture of saccharomyces cerevisiae and candida, the inoculation amount of the microzyme is 6-9wt% of the weight of the culture medium, and the addition ratio of the saccharomyces cerevisiae to the candida is 1: 5-10; inoculating mature strains into the sterilized mixture for fermentation to obtain fermentation liquor;
adding pectinase and cellulase into the fermentation liquor, uniformly stirring, adjusting the temperature to 30-60 ℃, and reacting for 1-2 hours; then heating and demulsifying; centrifuging by a centrifuge, and collecting the upper layer vegetable oil.
2. The hand cream as claimed in claim 1, wherein the pulverization of the step one is to 10-50 mesh, and the high temperature sterilization time is 10-20 minutes.
3. The hand cream according to claim 1, wherein the liquid medium in step two is YPD medium suitable for growth and propagation of yeast, and is cultured with aeration at 30-40 deg.C for 1-3 days.
4. The hand cream as claimed in claim 1, wherein the inoculation amount of the mature bacterial spawn in the second step is 5-10wt% of the weight of the sterilized mixture, and the fermentation is: fermenting at 25-35 deg.C with ventilation of 1-4VVM for 1-3 days.
5. The hand cream as claimed in claim 1, wherein the addition amount of pectinase in step three is 10-100U/mL, and the addition amount of cellulase is 10-100U/mL.
6. The hand cream as claimed in claim 1, wherein the temperature-raising demulsification in step three is temperature-raising to 80-85 ℃ for demulsification treatment for 10-30 minutes, and the centrifugation is 1000-5000rpm for 10-30 minutes.
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