CN115887332A - Skin-firming and anti-wrinkle composition and application thereof - Google Patents
Skin-firming and anti-wrinkle composition and application thereof Download PDFInfo
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- CN115887332A CN115887332A CN202211738430.4A CN202211738430A CN115887332A CN 115887332 A CN115887332 A CN 115887332A CN 202211738430 A CN202211738430 A CN 202211738430A CN 115887332 A CN115887332 A CN 115887332A
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Abstract
The invention relates to the technical field of daily skin care products, and provides a skin-tightening and anti-wrinkle composition which comprises the following components in percentage by mass: comprises the following components: euglena gracilis polysaccharide, hydrolyzed collagen, cordyceps extract, flos Matricariae Chamomillae extract, milk protein, SEPITONIC M3, mu-conopeptide, acetyl hexapeptide-8, procyanidine and beta-glucan. The skin anti-wrinkle composition provided by the invention improves the skin firming and anti-wrinkle effects of the composition from inside to outside and from multiple aspects based on the wrinkle formation mechanism and the aging performance.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to a skin-tightening and anti-wrinkle composition and application thereof.
Background
Skin aging is a process of making the human body function or develop rapidly or slowly naturally under the influence of internal and external factors, mainly due to endogenous aging and exogenous aging. Endogenous aging is an irresistible complex natural law and mainly shows that cell metabolism is gradually slowed down, collagen is gradually lost, collagen is damaged, hormone secretion is disordered, fat content begins to be reduced, partial cells are naturally killed and the like, and the conditions that skin loses elasticity and luster, skin is dried to generate wrinkles, and even melanin pigmentation, senile plaques are generated and the like are accelerated on the skin. Exogenous aging is mainly affected by environmental pollution, excessive ultraviolet irradiation, haze, computer blue light radiation, high working pressure, irregular diet, night-out, excessive intake of irritant food and other factors.
Reducing substances for resisting free radicals contained in plant extracts are generally used as effective components in the market, and the reducing substances are simply mixed according to a certain proportion, so that the comprehensive effect is difficult to satisfy.
For example, CN108904408A discloses a formula of an anti-wrinkle product, which is mainly prepared from carnosine, a tremella extract, hydrolyzed collagen, fullerene, hydrolyzed hyaluronic acid, a pelargonium graveolens extract and the like, and can moisten skin, improve skin metabolism, tighten skin, repair fine wrinkles, resist wrinkles, aging and the like.
For example, CN107007501A discloses an anti-aging composition comprising ginseng extract, equisetum extract and arillus longan extract. The anti-aging composition simultaneously comprises the ginseng extract, the equisetum extract and the arillus longan extract, the ginseng extract, the equisetum extract and the arillus longan extract are complementary in action mechanism, and the combined anti-aging effect is more obvious. The preparation method of the anti-aging composition provided by the invention is simple, the production time is saved, the stability of active ingredients can be kept in the preparation process, and the product also has an obvious free radical scavenging effect. However, barrier repair and immunity improvement on aging fragile skin are not considered, and an ideal health state is not achieved.
Therefore, it is highly desirable to provide a composition for improving the skin-tightening and anti-wrinkle effects from the inside out.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a skin-firming and anti-wrinkle composition, which improves the skin-firming and anti-wrinkle effects from inside to outside in various aspects.
In order to achieve the purpose, the invention adopts the following technical scheme:
a skin-firming and anti-wrinkle composition comprises the following components in parts by weight:
preferably, the euglena gracilis polysaccharide is prepared by biological fermentation of euglena gracilis.
Preferably, the hydrolyzed collagen is extracted from fish skin.
Preferably, the preparation method of the cordyceps sinensis extract comprises the following steps: drying the washed Cordyceps at low temperature of 15 deg.C, controlling water content within 10%, pulverizing, and adding 90 times of distilled water to obtain mixed solution; heating the mixed solution to 30-35 deg.C, and performing ultrasonic extraction at 25-30KHZ to obtain crude extract of 20-25 min; filtering the crude extractive solution with microporous membrane, and removing solid impurities to obtain filtrate as Cordyceps extract.
Preferably, the mass ratio of the euglena gracilis polysaccharide to the hydrolyzed collagen is 9.
Preferably, the skin-firming and anti-wrinkle composition comprises the following components in parts by weight:
the invention provides a skin care product, which comprises the skin firming and anti-wrinkle composition in any one of the technical schemes and acceptable auxiliary materials in the field of skin care products.
Preferably, the skin firming and anti-wrinkle composition is added into the skin care product in an amount of 0.3wt% to 6wt%.
The components of the composition of the invention function as follows:
the hydrolyzed collagen has a very low molecular weight and is easily absorbed by the skin, and can effectively help increase skin firmness and elasticity.
The euglena minutissima polysaccharide comprises glucan and mannan as main components, and the euglena minutissima polysaccharide and the hydrolyzed collagen are compounded according to the proportion to be used for forming a transparent film on the skin, so that the softness and the elasticity of the skin are increased, the moisture retention capacity is stronger, fine wrinkles and deep wrinkles of the skin can be improved, the effect of immediate tightening is achieved, and the wrinkles can be lifted instantly.
The chamomile extract contains 27 kinds of triterpenoids with anti-inflammatory effect, and has inhibitory effect on induced allergy of skin; can enhance capillary resistance, inhibit capillary permeability, and has antiinflammatory effect; meanwhile, the health care product has the effects of soothing nerves, helping sleep, relieving pain, beautifying and protecting skin and soothing mood.
Acetyl hexapeptide-8 has the effect of inhibiting acetylcholine release by a botulinum toxin without cytotoxicity of Botox, has a structure similar to SNAP-25, competes with SNAP-25 for occupying the position of SNAP-25 in SNARE combination, thereby inhibiting the formation of SNARE, reducing the release of neurotransmitter acetylcholine from synaptic vesicles to the synaptic area of neuromuscular, and reducing the expression striations on the skin surface caused by muscle contraction.
Mu-conopeptide targets various voltage sensitive sodium channels to generate electrostatic effect, block Nav1.4 sodium ion channels and reduce the passing of bioelectric signals. The invention combines acetyl hexapeptide-8 and mu-conopeptide for use, and the two can play complementary roles in mechanism, thereby reducing the release of acetylcholine, reducing the passing of bioelectric signals generated by acetylcholine stimulation, relaxing skin contraction caused by expression wrinkles, eliminating the effect of micro-tension on the skin, and reducing fine lines and wrinkles of the skin.
SEP I TON I C M3 is produced by French Saibox company, and the names of components I NC I are respectively: magnesium aspartate (CAS: 1187-91-3), zinc gluconate (CAS: 4468-02-4), copper gluconate (CAS: 527-09-3); the SEPI TON IC M3 has certain adsorption and flocculation effects on air pollutants, can reduce the toxicity of the air pollutants on the skin, has good skin cell energy supplement effect, promotes skin metabolism, self-purifies cells, expels toxins and the like.
The cordyceps sinensis extract is rich in polysaccharide, mannitol, adenosine and a plurality of amino acid components with the same structure as human skin cuticle NMF, and has the synergistic SEP I TON I C M3 effects of adsorbing, flocculating, neutralizing toxicity and the like on heavy metals and pollutants in the air; has obvious functions of repairing cuticle, strengthening skin barrier and preventing external pollution from entering deep skin to cause damage.
The milk protein improves the cell cohesion through protein crosslinking, can quickly form physical compactness, and enables the skin surface to be smoother through the action mechanism of physical film forming with the euglena gracilis polysaccharide, thereby achieving the effect of instant compactness.
The beta-glucan can improve the immunity of the skin, help the tissues of the damaged skin to recover and produce cytomin, and particularly has a certain effect on the skin with hormone-dependent dermatitis or damaged skin barrier function. Beta-glucan is also effective in wrinkle treatment of the skin, and can increase epidermal growth factor to promote the increase of collagen and elastin in the skin, and at the same time, the glucan has sunscreen effect and can reduce local inflammation and pain; also has certain antiallergic effect, and can be used for promoting repair of sensitive skin.
Procyanidin is plant polyphenol, is a secondary metabolite in the plant growth process, is a powerful antioxidant and natural complex, can eliminate free radicals and prevent skin aging, procyanidin can prevent the generation of free radicals generated by smoking, the free radicals are harmful to skin compared with sunlight, and the free radicals are atoms or atomic groups with strong activity in human body and can oxidize other substances in human body.
The invention has the beneficial effects that: (1) Through the transparent film compounded by the euglena gracilis polysaccharide, the hydrolyzed collagen and the milk protein, the smooth skin is instantly compacted from the aspect of physical compaction, meanwhile, the hydrolyzed collagen can stay in the deep epidermal layer for a long time to promote the synthesis of the collagen to bring an endogenous anti-aging effect, and can also provide a long-acting moisturizing effect, strengthen the skin hydration effect, strengthen the material barrier and the permeation barrier of the skin, and exogenously reduce the damage of the external environment to the skin. (2) The SEPITONI C M3 further supplements energy for skin cells endogenously, promotes skin metabolism, exogenously reduces the toxic effect of external pollutants on the skin, avoids the damage caused by the external pollutants entering the deep layer of the skin under the action of strengthening the skin barrier by the cordyceps sinensis extract, and plays a role in improving the chemical poison barrier effect of the skin and the permeation effect of chemical poisons. (3) The chamomile extract has the effects of resisting inflammation and allergy, improving the antibacterial barrier of skin to microorganisms and the immune barrier to antigens in an exogenous manner, relieving and helping sleep, improving the sleep quality, promoting the metabolism of cells, reducing the damage of the external environment to the skin, preventing epidermal keratosis, dermal elastic fiber deformation and the like, and further playing the effects of tightening the skin and resisting wrinkles. (4) Through the compounding of the mu-conopeptide and the acetyl hexapeptide-8, the release of acetylcholine is reduced, the passing of bioelectricity signals generated by the stimulation of the acetylcholine is reduced, and the muscle contraction on the surface of the skin is endogenously reduced in the aspect of biochemistry, namely, the inherent anti-wrinkle capability of the skin is improved, so that the wrinkles of the skin are reduced. (5) Procyanidine endogenously removes active free radicals and delays skin aging, thereby achieving the effects of firming the skin and resisting beating; the beta-glucan endogenously promotes the increase of collagen, enhances the skin elasticity, improves the hydration degree, and prevents the loss of excessive moisture and electrolytes of the skin; the beta-glucan is cooperated with the chamomile extract to improve the antibacterial barrier of the skin to microorganisms and the immune barrier to antigens, and further reduce the photoaging effect of ultraviolet rays. (6) Based on the wrinkle formation mechanism and aging performance, the skin firming and wrinkle resisting effect of the composition is improved from inside to outside and from multiple aspects.
Detailed Description
The invention is further described below with reference to examples, but the scope of the invention as claimed is not limited to the examples.
The skin firming and anti-wrinkle composition comprises the following components in parts by weight as shown in the following table 1:
TABLE 1
The preparation method of the cordyceps sinensis extract in examples 1 to 5 is as follows: selecting high-quality Cordyceps, washing with clear water to remove particles and impurities, drying at 15 deg.C, controlling water content within 10%, pulverizing to 15-30 μm, and adding 90 times of distilled water to obtain mixed solution; heating the mixed solution to 30-35 deg.C, starting ultrasonic wave of 25-30KHZ to assist extraction for 20-25min, repeatedly extracting for 2-3 times, and filtering to obtain crude extract; filtering the crude extractive solution with microporous membrane with pore diameter of 0.25-0.4 μm, and removing solid impurities to obtain filtrate.
The preparation method of the cordyceps sinensis extract has the advantages that: cleaning and drying the cordyceps sinensis until the moisture content is within 10 percent, and being most beneficial to preserving the essential components of the cordyceps sinensis; drying at 15 deg.C to ensure the activity of amino acids, adenosine and various enzymes in Cordyceps sinensis is not destroyed; the dissolution rate of the refined flower components can be greatly increased by combining the ultrasonic extraction technology on the basis of crushing to the particle size of 15-30 mu m.
The skin firming and anti-wrinkle compositions of examples 1-5 above were prepared as follows: adding euglena gracilis polysaccharide, hydrolyzed collagen, milk protein, SEPITONIC M3, mu-conopeptide, acetyl hexapeptide-8 and beta-glucan in parts by weight into a stirrer, heating to 60 ℃, stirring for 15-20 min, fully mixing, cooling to below 40 ℃, adding the rest components, uniformly stirring, and discharging to obtain the product.
The invention also provides the following comparative examples:
comparative example 1, the milk protein in the formula of example 3 was not contained, and the rest of the components, their contents and preparation method were the same as those of example 3.
Comparative example 2, the cordyceps sinensis extract in the formula of example 3 was not contained, and the rest components, the content thereof and the preparation method thereof were the same as those of example 3.
Comparative example 3, the mu-conopeptide in the formula of example 3 is not contained, and the rest components, the content and the preparation method are the same as those in example 3.
The compositions in the comparative examples 1 to 3 of the grades 1 to 5 are respectively prepared into essence water with the effects of tightening skin and resisting wrinkles, and the formula is shown in the following table 2:
TABLE 2
The preparation method of the essence water comprises the following steps: heating water, thickener, humectant and chelating agent to 85 deg.C, stirring at 500 r/min for 15 min to mix well, and keeping the temperature for 20 min; cooling to 45 ℃, adding the preservative, and stirring and mixing uniformly; cooling to 40 ℃, sequentially adding the skin-firming and anti-wrinkle composition, uniformly stirring, and discharging to obtain the skin-firming and anti-wrinkle composition.
The effect test of the essence water is as follows:
(1) And (3) safety testing: 80 volunteers aged 20 to 50 years were recruited, each of which was tested at 10 persons, and spot-on tests were performed using the essence liquids of examples 1 to 5 and comparative examples 1 to 3, with an observation time of 24 hours, and the results were shown in the following table 4, in which the essence liquids were scored according to the criteria of table 3:
TABLE 3
TABLE 4
The above results show that: the essence water prepared in the examples 1-5 and the comparative examples 1-3 has no adverse reaction, low irritation and high safety.
(2) Tightening skin and resisting wrinkle test: the essence liquids of examples 1 to 5 and comparative examples 1 to 3 were administered to 10 test subjects who were subjected to the patch test, and the number of test subjects was 10 for each essence liquid. During the test period, the testee sprays a proper amount of the essence water every morning and evening, the abdomen is gently smeared and massaged until the essence water is absorbed, and the testee cannot smear any other products during the period from 0 day to 30 days; before testing, a subject sits quietly for 30 min in a testing environment to enable the skin to reach the most natural state, photographs are recorded by using VI SA-CR, after 5min of the essence water of the invention is sprayed, photographs are recorded on the face by using VI SA-CR, and then the wrinkle improvement rate and roughness before and after use are calculated by analysis software so as to reflect the instant tightening and wrinkle resisting effects of each essence water on the wrinkles on the face. After the face is cleaned on day 30, a photographing test is carried out to reflect the long-acting tightening anti-wrinkle effect of each essence on the wrinkles of the face; the following test data were obtained in table 5:
TABLE 5
The above results show that the essence solutions of examples 1 to 5 have good instant wrinkle removal effect, wherein the skin wrinkle improvement rate is above 10%, and the skin roughness improvement rate is above 18%; the skin care matrix prepared in the example 2 has the best instant wrinkle removal effect, but because the skin improvement rate of the example 3 is close to 13%, the example 3 can be selected as the optimal example based on the consideration of factors such as cost and the like; examples 4-5 compare with example 3 respectively, and when the weight ratio of euglena gracilis polysaccharide to hydrolyzed collagen is 9; compared with the comparative examples 1-3, the milk protein, the mu-conopeptide and the cordyceps sinensis extract which are obtained in the comparative examples 1-3 respectively have synergistic anti-aging effects with other components in the composition, any component is absent in the composition, the effects are greatly reduced, and the effects of the components have immediate tightening and anti-wrinkle effects and long-acting tightening and anti-wrinkle effects only when the components act together.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (8)
1. The skin-firming and anti-wrinkle composition is characterized by comprising the following components in parts by weight:
2. the firming and anti-wrinkle composition according to claim 1, wherein the euglena gracilis polysaccharide is prepared from euglena by biofermentation.
3. The skin-firming and anti-wrinkle composition according to claim 1, wherein the hydrolyzed collagen is extracted from fish skin.
4. The skin-firming and anti-wrinkle composition according to claim 1, wherein the preparation method of the cordyceps sinensis extract comprises: drying the cleaned Cordyceps at 15 deg.C, controlling water content within 10%, pulverizing, and adding 90 times of distilled water to obtain mixed solution; heating the mixed solution to 30-35 deg.C, and starting ultrasonic wave for 25-30KHZ assisted extraction for 20-25min to obtain crude extract; filtering the crude extract with microporous membrane, and removing solid impurities to obtain filtrate as Cordyceps extract.
5. The firming and anti-wrinkle composition according to claim 1, wherein the weight ratio of the euglena parvopolysaccharide to the hydrolyzed collagen is 9.
6. The firming and anti-wrinkle composition according to claim 1, which comprises the following components in parts by weight:
7. use of the firming and anti-wrinkle composition according to any one of claims 1 to 6 for the preparation of a skin care product.
8. The use according to claim 7, wherein the firming and anti-wrinkle composition is added in the skin care product in an amount of 0.3wt% to 6wt%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116983232A (en) * | 2023-07-27 | 2023-11-03 | 广州名门闺秀生物科技有限责任公司 | Compact anti-wrinkle composition, and preparation method and application thereof |
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