CN114652763A

CN114652763A - Plant fermentation allergy-relieving composition and preparation method and application thereof

Info

Publication number: CN114652763A
Application number: CN202011539786.6A
Authority: CN
Inventors: 肖明华; 张海波; 张彦; 彭宁; 覃敬羽; 杨树金
Original assignee: Angel Nutt Co ltd
Current assignee: Angel Nutt Co ltd
Priority date: 2020-12-23
Filing date: 2020-12-23
Publication date: 2022-06-24
Anticipated expiration: 2040-12-23
Also published as: CN114652763B

Abstract

The invention relates to a plant fermentation allergy-relieving composition, a preparation method and application thereof, wherein the composition comprises 0.05-2 parts by weight of polyphenol, 0.5-5 parts by weight of crude polysaccharide and 0.1-3 parts by weight of organic acid. Preferably, the allergy-soothing composition is obtained by fermenting yeast in a plant fermentation substrate, wherein the fermentation substrate comprises chamomile, centella asiatica, peony, pseudo-ginseng, purslane, cactus and scutellaria baicalensis. The preparation method of the composition comprises the following steps: mixing the components in the fermentation substrate, adding water, heating to the temperature of 100-120 ℃, sterilizing, cooling to the temperature of 20-35 ℃, inoculating fermentation strains for fermentation, and filtering and sterilizing to obtain the plant fermentation allergy-relieving composition. The plant fermentation allergy-relieving composition can relieve skin allergy, resist bacteria and diminish inflammation, promote skin cell renewal and achieve the effects of resisting allergy and relieving allergy.

Description

Plant fermentation allergy-relieving composition and preparation method and application thereof

Technical Field

The invention relates to the technical field of skin care, mainly relates to the technical field of skin care product production, and particularly relates to a plant fermentation allergy-relieving composition as well as a preparation method and application thereof.

Background

Skin allergy is a common skin disease, allergic people have sensitive skin, and adverse reactions can also occur when the cosmetic is applied to the skin easily. Common lipsticks, hair dyes and the like exist, and after the use, the problems of skin allergy such as red, swelling, heat, itching, pain, blister and the like appear. The inhibition and resistance of skin allergy are very important problems from the skin physiological and medical and cosmetic perspectives. Although the traditional control method treatment such as hormone treatment, antihistamine treatment and anti-inflammatory drug treatment can relieve and treat the skin allergy problem and symptoms within a certain time, if the traditional control method treatment is not used properly, the skin disease is likely to be aggravated, and even irreparable lesions of the skin can be caused. Therefore, the method is quite worthy of being researched for how to safely and effectively inhibit the skin allergy. How to reduce the allergic rate of cosmetics is a problem which needs to be solved urgently at present, and some enterprises add prohibited substances such as glucocorticoid to solve the problem, for example, in a unqualified cosmetic list published by the Guangdong food and drug administration 2015 at the 3 rd stage, 15 companies find out that the glucocorticoid is illegally added, and the long-term use of products containing glucocorticoid can cause serious consequences such as skin dependence and even ulceration. Therefore, the research of the plant-derived soothing agents is an important research direction at present and has practical significance for the cosmetic industry.

Research shows that substances with effective anti-aging and anti-allergic effects exist in a plurality of natural plant extracts, and the substances can be used for preparing cosmetics, skin care products or medicaments with anti-aging or anti-allergic effects. Natural plants or extracts thereof include: chamomile, witch hazel, scutellaria baicalensis, folium artemisiae argyi, grape seeds, blueberry, ginkgo, hawthorn, liquorice extract, glycyrrhizic acid, aloe, chamomile blue, peony, astragalus mongholicus, honeysuckle, indigowoad root bloom, centella asiatica, peony, kiwi fruit, roxburgh rose, calendula, lotus seeds, saussurea involucrate, ginseng, lavender, seaweed, honeysuckle, coix seed, lucid ganoderma, green tea, poria cocos and the like.

There are many studies of interest, CN200810033341.3 discloses an anti-aging and anti-allergy composition comprising: anti-aging and anti-allergy active ingredients prepared by mixing natural alpha-bisabolol of plant extracts and procyanidine, and a carrier acceptable for cosmetics, skin care products or medicines. The composition can produce anti-aging and anti-allergic effects far superior to those of natural alpha-bisabolol or proanthocyanidin used alone when applied to the skin. CN201510684956.2 discloses a plant desensitizer and a preparation method thereof, the preparation method comprises: weighing raw materials in proportion, and adding the raw materials into an extraction device for extraction to obtain an extracting solution A; filtering the extract A, and taking the permeated liquid as an extract B; concentrating the extract B to obtain the final product, namely the plant soothing and sensitizing agent; the raw materials comprise the following components in parts by weight: 20-30 parts of liquorice, 20-30 parts of sweet wormwood, 10-20 parts of gentian, 10-20 parts of radix sophorae flavescentis and 10-20 parts of fructus cnidii. The plant soothing agent for cosmetics is prepared by adopting a specific process, and is effective, stable and light in color. The prepared plant allergy relieving agent comprises 0.25-0.35% of glycyrrhizic acid and 0.61-0.87 mg/ml of artemisinin in percentage by mass. CN201310374302.0 discloses a plant composition with the effects of moisturizing, removing wrinkles and soothing allergy and a preparation method thereof. The active ingredients of the traditional Chinese medicine composition are water extracts of the following raw materials: herba Dendrobii, pansy, radix Ophiopogonis, Tremella and herba Avenae Fatuae; wherein the oat raw material is oat grains, oat flour or oat bran. In the composition, the mass ratio of the dendrobium to the pansy to the ophiopogon root to the tremella to the oat is 5-15: 2-10: 2-10: 1-5: 1-5, in particular 12: 6: 3: 2: 2. the invention selects the five plants of dendrobium, pansy, ophiopogon root, oat raw material and tremella to be combined and extracted for external use, and achieves the effects of moisturizing, delaying skin aging, resisting sensitivity and preventing chapping through the ways of retaining water, maintaining the physiological function of normal aquaporin and the like.

Disclosure of Invention

The technical problem solved by the invention is as follows: the safety and the efficacy of the existing allergy relieving agent are still to be improved, and the application of the plant fermentation composition to the skin relieving and anti-allergy effects is not seen at present.

The purpose of the invention is: the plant fermentation soothing agent is prepared by performing proper structural modification on active ingredients in natural plants through the biotransformation of microorganisms in a biological fermentation process to improve the efficacy of products and reduce the irritation to skin, and the active ingredients are synergistic with metabolites of the microorganisms, such as polypeptides, organic acids and amino acids, to improve the efficacy of the products.

In order to solve the technical problems, the invention provides a plant fermentation sensitizer, and a fermentation substrate comprises 0.1-30% of chamomile, 0.1-10% of centella asiatica, 0.1-20% of peony, 0.1-5% of pseudo-ginseng, 0.1-30% of purslane, 0.1-30% of cactus and 0.1-5% of scutellaria baicalensis. The prepared composition product has obvious allergy-relieving efficacy through efficacy tests.

Specifically, aiming at the defects of the prior art, the invention provides the following technical scheme:

the plant fermentation allergy-relieving composition is characterized by comprising the following components:

0.05-2 parts of polyphenol, 0.5-5 parts of crude polysaccharide and 0.1-3 parts of organic acid.

Preferably, the plant fermentation desensitizing composition comprises the following components: 0.05-2 wt% of polysaccharide, 0.5-5 wt% of crude polysaccharide, 0.1-3 wt% of organic acid and 85-98 wt% of water.

Wherein the organic acid comprises tartaric acid, malic acid, citric acid and succinic acid.

Preferably, in the plant fermentation desensitizing composition, the polyphenol is 0.08-2 parts by weight, preferably 0.08-1 part by weight, and more preferably 0.1-0.8 part by weight.

Preferably, in the plant fermentation desensitizing composition, the crude polysaccharide is 1 to 5 parts by weight, preferably 1.5 to 3.0 parts by weight, and more preferably 2.5 to 3.0 parts by weight.

Preferably, in the plant fermentation desensitizing composition, the organic acid is 0.5 to 3 parts by weight, preferably 0.5 to 1.0 part by weight.

Preferably, the plant fermentation allergy-relieving composition comprises 0.4-0.6 part by weight of polyphenol, 2.5-3.0 parts by weight of crude polysaccharide and 0.8-1.0 part by weight of organic acid.

Preferably, in the above plant fermentation allergy-relieving composition, the allergy-relieving composition is obtained by fermenting yeast in a plant fermentation substrate, and the fermentation substrate includes chamomile, centella asiatica, peony, notoginseng, purslane, cactus and scutellaria baicalensis.

Preferably, in the above plant fermentation allergy-relieving composition, the fermentation substrate comprises chamomile 0.1-30 parts by weight, centella asiatica 0.1-10 parts by weight, peony 0.1-20 parts by weight, notoginseng 0.1-5 parts by weight, purslane 0.1-30 parts by weight, cactus 0.1-30 parts by weight and scutellaria baicalensis 0.1-5 parts by weight.

Preferably, in the above plant fermentation allergy-relieving composition, the fermentation substrate comprises chamomile 0.1-30 parts by weight, centella asiatica 5-10 parts by weight, peony 0.1-20 parts by weight, notoginseng 3-5 parts by weight, purslane 0.1-30 parts by weight, cactus 4.5-30 parts by weight and scutellaria baicalensis 0.1-5 parts by weight.

Preferably, in the plant fermentation allergy-relieving composition, the fermentation substrate comprises 20-30 parts by weight of chamomile and 15-20 parts by weight of peony.

Preferably, in the above plant fermentation allergy-relieving composition, the fermentation substrate comprises 30 parts by weight of chamomile, 10 parts by weight of centella asiatica, 20 parts by weight of peony, 5 parts by weight of notoginseng, 0.1-30 parts by weight of purslane, 4.5-30 parts by weight of cactus and 0.1-5 parts by weight of scutellaria baicalensis.

Preferably, in the above plant fermentation allergy-relieving composition, the fermentation substrate comprises 30 parts by weight of chamomile, 10 parts by weight of centella asiatica, 20 parts by weight of peony, 5 parts by weight of notoginseng, 0.1-0.5 part by weight of purslane, 29.5-29.9 parts by weight of cactus and 5 parts by weight of scutellaria baicalensis.

Preferably, in the above plant fermentation allergy-relieving composition, the fermentation substrate comprises one or more of witch hazel, folium artemisiae argyi, grape seed, blueberry, ginkgo, hawthorn, licorice extract or glycyrrhizic acid, aloe, chamomile blue, astragalus membranaceus, honeysuckle, indigowoad root flower, peony, kiwi fruit, roxburgh rose, calendula, lotus seed, snow lotus, ginseng, lavender, seaweed, honeysuckle, coix seed, ganoderma, green tea and poria cocos.

The invention also provides a preparation method of the plant fermentation allergy-relieving composition, which comprises the following steps:

mixing the components in the fermentation substrate, adding water, heating to 100-120 ℃, sterilizing, cooling to 20-35 ℃, inoculating a fermentation strain for fermentation, and filtering and sterilizing to obtain the plant fermentation allergy-relieving composition.

Preferably, in the above preparation method, the fermentation bacteria is selected from lactic acid bacteria and/or yeast.

Preferably, in the above preparation method, the mass ratio of the fermentation substrate to water is 1 (5-100), preferably 1 (10-50).

Preferably, in the above preparation method, the temperature-raising treatment time is 10 to 60 min.

Preferably, in the preparation method, the fermentation time is 3-120 h; preferably, the fermentation time is 24-96 h.

The invention also provides application of the plant fermentation allergy-relieving composition in the fields of skin care products, cosmetics or medicines.

The invention has the advantages that: the composition provided by the invention can relieve skin allergy, resist bacteria and inflammation, promote skin cell renewal and achieve the effects of resisting allergy and relieving.

Detailed Description

In view of the fact that the safety and the efficacy of the existing skin allergy-relieving agent are still to be improved, the invention provides a plant fermentation allergy-relieving agent and a preparation method and application thereof.

In a preferred embodiment, the fermentation substrate of the soothing agent comprises chamomile 0.1-30%, centella asiatica 0.1-10%, peony 0.1-20%, notoginseng 0.1-5%, purslane 0.1-30%, cactus 0.1-30%, and scutellaria baicalensis 0.1-5%.

The preparation process comprises the following steps: crushing, mixing, sterilizing, fermenting, filtering and filling.

In another preferred embodiment, the process for preparing the soothing agent of the invention comprises the following steps: pulverizing the above Chinese medicinal materials, mixing at a certain proportion, adding 5-100 times (m/m) of purified water, treating at 120 deg.C for 10-60min at 100 deg.C, cooling to 20-35 deg.C, inoculating yeast or lactobacillus, fermenting for 3-120h, filtering, sterilizing, and bottling to obtain the final product.

The plant fermentation sensitizer of the present invention, its preparation method and application are further illustrated by the following specific examples.

In the following examples, the information on the raw materials used is as follows:

HaCaT cells (human immortalized keratinocytes) used in this assay were purchased from Shangen cell Bank, cell catalog number SNL-163.

Yeast, manufacturer: angel Yeast, Inc., model number: high activity dry yeast; the goods number is: 2018091221.

lactic acid bacteria, manufacturer: angel Yeast, Inc., Cathaki, Inc.: 20190909.

chamomile, centella asiatica, peony, pseudo-ginseng, purslane, cactus and scutellaria baicalensis, and the sources are as follows: xianchang Yue Biotechnology Co., Ltd.

Example 1

Crushing the Chinese herbal medicines in the example 1 in the table 1 to 40 meshes, mixing the Chinese herbal medicines according to the proportion in the example 1 in the table 1, adding 5 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition in the example 1 in the table 2, stirring the mixture at 100 ℃ for 60min, cooling the mixture to 20 ℃, adding 0.1 wt% of yeast, fermenting the mixture for 3h, filtering the mixture after the fermentation is finished, sterilizing the mixture for 1h at 95 ℃, and filling the mixture to obtain the finished product of the soothing agent.

Detecting a finished product of the comfort agent: the polyphenol content is determined according to the method specified in appendix A of GB/T31740.2, the crude polysaccharide content is determined according to the method specified in SN/T4260, the organic acid content (total amount of tartaric acid, malic acid, citric acid and succinic acid) is determined according to the method specified in GB5009.157, and the water content is determined according to the method specified in NY/T2321.

Through detection, the components in the desensitizer product obtained in example 1 are 0.08% of polyphenol, 0.8% of crude polysaccharide, 0.2% of organic acid and 92% of water.

Example 2

Crushing the Chinese herbal medicines in the table 1 to 80 meshes, mixing the Chinese herbal medicines according to the proportion in the example 2 in the table 1, adding 100 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition in the example 2 in the table 2, stirring the mixture at 120 ℃ for 10min at the stirring speed of 100r/min, cooling the mixture to 35 ℃, inoculating 0.1 wt% of yeast, fermenting the mixture for 12h, filtering the mixture after the fermentation is finished, sterilizing the mixture for 0.5h at 121 ℃, and filling the mixture to obtain the finished product of the allergy-relieving agent.

The detection shows that the components of the obtained soothing agent product comprise 0.05% of polyphenol, 0.6% of crude polysaccharide, 0.2% of organic acid and 98% of water.

Example 3

Crushing the Chinese herbal medicines in the table 1 to 20 meshes, mixing the Chinese herbal medicines according to the proportion in the example 3 in the table 1, adding 5 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition in the example 3 in the table 2, stirring the mixture at 100 ℃ for 60min at the stirring speed of 100r/min, cooling the mixture to 25 ℃, inoculating 1 wt% of yeast, fermenting the mixture for 72h, filtering the mixture after the fermentation is finished, sterilizing the mixture at 100 ℃ for 0.5h, and filling the mixture to obtain the finished product of the soothing agent.

Through detection, the components in the obtained soothing agent product comprise 0.3% of polyphenol, 2.4% of crude polysaccharide, 0.2% of organic acid and 92% of water.

Example 4

Crushing the Chinese herbal medicines in the table 1 to 80 meshes, mixing the Chinese herbal medicines according to the proportion of example 4 in the table 1, adding 100 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition of example 4 in the table 2, stirring the mixture at 120 ℃ for 20min at the stirring speed of 100r/min, cooling the mixture to 30 ℃, inoculating 1 wt% of yeast, fermenting the mixture for 120h, filtering the mixture after the fermentation is finished, sterilizing the mixture for 2h at 90 ℃, and filling the mixture to obtain the finished product of the soothing agent.

The detection shows that the components of the obtained soothing agent product comprise 0.05% of polyphenol, 0.9% of crude polysaccharide, 0.2% of organic acid and 98% of water.

Example 5

Crushing the Chinese herbal medicines in the table 1 to 60 meshes, mixing according to the proportion in the example 5 in the table 1, adding 10 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition in the example 5 in the table 2, stirring at 120 ℃ for 20min at the stirring speed of 100r/min, cooling to 20 ℃, inoculating 2 wt% of lactic acid bacteria, fermenting for 24h, filtering after fermentation, sterilizing at 100 ℃ for 1h, and filling to obtain the finished product of the soothing agent.

Through detection, the components in the obtained soothing agent product comprise 0.5% of polyphenol, 2.8% of crude polysaccharide, 0.8% of organic acid and 87% of water.

Example 6

Crushing the Chinese herbal medicines in the table 1 to 20 meshes, mixing the Chinese herbal medicines according to the proportion in the example 6 in the table 1, adding 50 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition in the example 6 in the table 2, treating the mixture at 100 ℃ for 40min, cooling the mixture to 35 ℃, inoculating 2 wt% of lactic acid bacteria, fermenting the mixture for 48h, filtering the mixture after the fermentation is finished, sterilizing the mixture for 1h at 100 ℃, and filling the mixture to obtain the finished product of the soothing agent.

The detection shows that the components of the obtained soothing agent product are 0.06% of polyphenol, 0.9% of crude polysaccharide, 0.6% of organic acid and 95% of water.

Example 7

Crushing the Chinese herbal medicines in the table 1 to 40 meshes, mixing the Chinese herbal medicines according to the proportion of example 7 in the table 1, adding 20 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition of example 7 in the table 2, stirring the mixture at 120 ℃ for 20min at the stirring speed of 100r/min, cooling the mixture to 25 ℃, inoculating 0.5 wt% of lactic acid bacteria, fermenting the mixture for 96h, filtering the mixture after the fermentation is finished, sterilizing the mixture for 2h at 80 ℃, and filling the mixture to obtain the finished allergy-relieving agent.

Through detection, the components in the obtained soothing agent product comprise 0.09% of polyphenol, 1.9% of crude polysaccharide, 0.7% of organic acid and 90% of water.

Example 8

Crushing the Chinese herbal medicines in the table 1 to 20 meshes, mixing the Chinese herbal medicines according to the proportion in the example 8 in the table 1, adding 20 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition in the example 8 in the table 2, stirring the mixture at the temperature of 120 ℃ for 20min at the stirring speed of 100r/min, cooling the mixture to 30 ℃, inoculating 0.5 wt% of lactic acid bacteria, fermenting the mixture for 72h, filtering the mixture after the fermentation is finished, sterilizing the mixture at the temperature of 121 ℃ for 0.5h, and filling the mixture to obtain the finished allergy-relieving agent.

The detection shows that the components of the obtained soothing agent product comprise 0.08% of polyphenol, 2.1% of crude polysaccharide, 0.09% of organic acid and 96% of water.

Example 9

Crushing the Chinese herbal medicines in the table 1 to 80 meshes, mixing the Chinese herbal medicines according to the proportion of example 9 in the table 1, adding 10 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition of example 9 in the table 2, heating and sterilizing the mixture at 120 ℃ for 20min, cooling the mixture to 35 ℃, inoculating 2 wt% of lactic acid bacteria, fermenting the mixture for 120h, filtering the mixture after the fermentation is finished, sterilizing the mixture for 1h at 100 ℃, and filling the mixture to obtain the finished product of the allergy-relieving agent.

Through detection, the components in the allergy-relieving agent product comprise 2% of polyphenol, 5% of crude polysaccharide, 3% of organic acid and 90% of water.

Example 10

Crushing the Chinese herbal medicines in the table 1 to 80 meshes, mixing the Chinese herbal medicines according to the proportion of example 10 in the table 1, adding 20 times of water by mass into the Chinese herbal medicine mixture according to the fermentation condition of the example 10 in the table 2, heating and sterilizing the mixture at 100 ℃ for 30min, cooling the mixture to 28 ℃, inoculating 1 wt% of yeast, fermenting the mixture for 96h, filtering the mixture after the fermentation is finished, sterilizing the mixture at 120 ℃ for 15min, and filling the mixture to obtain the finished product of the allergy-relieving agent. The detection shows that the components in the allergy-relieving agent product comprise 1% of polyphenol, 3.5% of crude polysaccharide, 1.5% of organic acid and 93% of water.

Comparative example 1

The fermentation substrate is: 0.3 percent of chamomile, 85.5 percent of purslane and 14.2 percent of scutellaria baicalensis, and the soothing agent product is prepared according to the same method as the embodiment 1.

The detection shows that the components of the obtained soothing agent product comprise 0.05% of polyphenol, 0.8% of crude polysaccharide, 0% of organic acid and 95% of water.

Table 1 example fermentation substrate composition and proportions

TABLE 2 fermentation conditions of the examples

The products of the phlegmatizers obtained in examples 1 to 10 and comparative examples were used in cytology experiments as follows:

after HACaT cells were stimulated to model with SLS (sodium dodecyl sulfate), lyophilized powder (concentration of 0.2mg/mL) of the composition of examples 1-8 was allowed to act together with HaCaT cells for 24 hours, and then the growth rate of ROS (reactive oxygen species), SOD (superoxide dismutase), and MDA (malondialdehyde) in HaCaT cells was measured at a concentration of 0.2mg/mL as compared to that in the model group. The specific experimental method is as follows:

1. stimulation model making

Culture of HaCaT cells: the HaCaT cells were recovered and inoculated into 12-well plates at a plating density of 50% in a DMEM-high sugar medium (Gibco Co., Ltd.) at 37 ℃ with 5% CO₂Culturing in an incubator for 24h under the condition.

Cell passage: changing the culture medium to fresh DMEM-high sugar culture solution; HaCaT cells are inoculated into a culture flask, SLS solution with the concentration of 50ug/mL is added, and the mixture is cultured for 24 hours in a 5% CO2 incubator at 37 ℃.

2. The compositions described in examples 1-10 and comparative examples were prepared as lyophilized powders by the following procedure:

and (3) putting the solution obtained in each embodiment into a freeze dryer, and drying to obtain the freeze-dried powder of the composition product in each embodiment.

3. Taking the examples 1-10 and the comparative example as model groups, adding 0.2mg/mL of freeze-dried powder of the composition obtained in the examples 1-10 into a cell culture solution to obtain experimental groups 1-10; after culturing in a 5% CO2 incubator at 37 ℃ for 24 hours, the growth rate of ROS (reactive oxygen species), SOD (superoxide dismutase) and MDA (malondialdehyde) of the HaCaT cells was examined compared with that of the model group. The results are shown in Table 3.

The ROS detection method comprises the following steps: ELISA kit method (BD Co.); the detection method of SOD comprises the following steps: ELISA kit method (BD Co.); the detection method of MDA comprises the following steps: ELISA kit method (BD Co.).

TABLE 3 cytological Experimental results

ROS and MDA are oxidation factors generated by skin cells due to external stimulation, and SOD is an oxidation factor. The results show that the ingredients of the examples are effective in relieving oxidative damage caused by irritation.

In conclusion, the plant fermentation allergy-relieving agent disclosed by the invention can relieve skin allergy, resist bacteria and diminish inflammation, promote skin cell renewal and achieve the effects of resisting allergy and relieving after the active ingredients in natural plants are subjected to appropriate structural modification.

Claims

1. The plant fermentation allergy-relieving composition is characterized by comprising the following components:

2. The phytofermentant phlegmatism composition according to claim 1, wherein the polyphenol is present in an amount of 0.08-2 parts by weight, preferably 0.08-1 parts by weight, more preferably 0.1-0.8 parts by weight.

3. Plant fermentation phlegmatism-relieving composition according to claim 1 or 2, wherein the crude polysaccharide is present in an amount of 1 to 5 parts by weight, preferably 1.5 to 3.0 parts by weight, more preferably 2.5 to 3.0 parts by weight.

4. Plant fermentation soothing composition according to any of the claims 1-3, wherein the organic acid is present in an amount of 0.5-3 parts by weight, preferably 0.5-1.0 parts by weight.

5. The plant fermented soothing composition according to any one of claims 1 to 4, wherein the soothing composition is obtained by fermenting yeast in a plant fermentation substrate comprising chamomile, centella asiatica, peony, notoginseng, purslane, cactus and scutellaria baicalensis.

6. The plant fermentation allergy-relieving composition of claim 5, wherein the fermentation substrate comprises chamomile 0.1-30 parts by weight, centella asiatica 0.1-10 parts by weight, peony 0.1-20 parts by weight, notoginseng 0.1-5 parts by weight, purslane 0.1-30 parts by weight, cactus 0.1-30 parts by weight and scutellaria baicalensis 0.1-5 parts by weight.

7. The plant fermentation allergy-relieving composition of claim 6, wherein the fermentation substrate comprises chamomile 0.1-30 parts by weight, centella asiatica 5-10 parts by weight, peony 0.1-20 parts by weight, notoginseng 3-5 parts by weight, purslane 0.1-30 parts by weight, cactus 4.5-30 parts by weight and scutellaria baicalensis 0.1-5 parts by weight.

8. The plant fermentation allergy-relieving composition according to claim 6 or 7, wherein the fermentation substrate comprises 20 to 30 parts by weight of chamomile and 15 to 20 parts by weight of peony.

9. The plant fermented allergy relief composition according to any one of claims 5 to 8, wherein the fermentation substrate comprises one or more of witch hazel, mugwort leaf, grape seed, blueberry, ginkgo biloba, hawthorn, licorice extract or glycyrrhizic acid, aloe, chamomile blue, astragalus, honeysuckle, indigowoad root bloom, peony, kiwi, rosa roxburghii, calendula, lotus seed, snow lotus, ginseng, lavender, seaweed, honeysuckle, coix seed, ganoderma lucidum, green tea and poria cocos.

10. A process for the preparation of a plant fermentation soothing composition according to any one of claims 1 to 9, comprising the steps of:

11. The method according to claim 10, wherein the fermentation strain is selected from lactic acid bacteria and/or yeast.

12. The method according to claim 10 or 11, wherein the mass ratio of the fermentation substrate to the water is 1 (5-100), preferably 1 (10-50).

13. Use of a phytofermentant phlegmatism composition according to any of claims 1-9 in the field of skin care, cosmetics or pharmaceuticals.