JP2000281555A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin preparation for external use, capable of giving an effect not processed by the same conventional skin preparations by paying an attention on the whitening effect or dyspigmentation-improving effect of bearberry leaf or its extract and then mixing the bearberry leaf or its extract with an agent for supplementing or promoting the effect. SOLUTION: This skin preparation for external use contains as a main component a composition obtained by formulating at least one substance selected from UV light absorbents, allantoin or its derivatives, and pantetheine or its salts with a mixture of bearberry leaf with L-ascorbic acid or its derivative or with a mixture of a bearberry leaf extract with L-ascorbic acid or its derivative.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention relates to the use of
Either an ascorbic acid or a derivative thereof, or an extract of Lilium spp. To which L-ascorbic acid or a derivative thereof has been added, and an ultraviolet absorber, allantoin or a derivative thereof, pantethine-S-sulfonic acid or a salt thereof The present invention relates to an external preparation for skin containing as a main component at least one compound selected from at least one selected from the group consisting of:

[0002]

2. Description of the Related Art It has been disclosed in Japanese Patent Application Laid-Open (JP-A) No. 6-1 / 1994 that ouwarushi or its extract is an active ingredient of a whitening agent or a pigmentation improving agent.
It has been clarified from the invention disclosed in US Pat. No. 66609.

[0003] That is, pigmentation such as spots, freckles, and black and white is said to be a disease caused as a result of excessive deposition of melanin on the skin. However, it has been found that they have an excellent whitening effect and an improvement effect of pigmentation as compared with synthetic arbutin conventionally used as a whitening agent.

[0004]

SUMMARY OF THE INVENTION The present invention focuses on the whitening effect or the improvement effect of pigmentation disease of the above-mentioned awaluushi or its extract, and prepares a preparation which complements or promotes the above-mentioned effect. It is an object of the present invention to provide a skin external preparation that can obtain an effect not found in conventional products of the same type when mixed into an extract to produce a skin external preparation.

[0005]

Means for Solving the Problems The purpose of the present invention for solving the above-mentioned problems is to provide an external preparation for skin according to the present invention, which is prepared by adding L-ascorbic acid or a derivative thereof to awaurushi or an extract of awaurushi. L-ascorbic acid or a derivative thereof is added, and at least one selected from one or more of an ultraviolet absorber, allantoin or a derivative thereof, pantethine-S-sulfonic acid or a salt thereof is blended, and It is characterized by having been used as a component.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION L-ascorbic acid to be added to ouwarushi or its extract in the present invention is generally called vitamin C, and has a strong reductive action to have a cell respiratory action, an enzyme activating action, a collagen forming action, and It has a melanin reducing effect. Examples of L-ascorbic acid derivatives include L-ascorbic acid monostearate and L-ascorbic acid monostearate.
L-ascorbic acid monoalkyl esters such as L-ascorbic acid monopalmitate, L-ascorbic acid monooleate, L-ascorbic acid monophosphate, L
L-ascorbic acid monoester derivatives such as ascorbic acid-2-sulfuric acid, L-ascorbic acid such as L-ascorbic acid diphosphate such as L-ascorbic acid distearate, L-ascorbic acid dipalmitate and L-ascorbic acid diallate. Acid diester derivatives,
Examples thereof include trialkyl esters such as L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid triolate, and ascorbic acid triester derivatives such as L-ascorbic acid triphosphate. In the present invention, one or more of these are appropriately selected and blended.

[0007] An external preparation for skin containing as an active ingredient a mulberry or its extract to which L-ascorbic acid or a derivative thereof is added according to the present invention will be described. As the ultraviolet absorber incorporated in the external preparation for skin, any ultraviolet absorber commonly used in conventional external preparations for skin can be used, and representative compounds of such ultraviolet absorbers will be exemplified. It is as follows.

(1) Benzoic acid-based ultraviolet absorbers paraaminobenzoic acid (hereinafter abbreviated as PABA), PAB
A monoglycerin ester, N, N-dipropoxy PA
BA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N
-Dimethyl PABA amyl ester, N, N-dimethyl PABA octyl ester,

(2) Anthranilic acid ultraviolet absorbers homomenthyl-N-acetylanthranilate

(3) Salicylic acid ultraviolet absorbers amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate

(4) Cinnamic acid ultraviolet absorber octylcinnamate, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4- Diisopropyl cinnamate, propyl-p
-Methoxycinnamate, isopropyl-p-methoxycinnamate, isoaluminum-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoaluminum-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p -Methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate,
2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate,

(5) Benzophenone ultraviolet absorber 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2 ', 4,4 '
-Tetrahydroxybenzophenone, 2-hydroxy-
4-methoxybenzophenone, 2-hydroxy-4-methoxy 4'-methylbenzophenone, 2-hydroxy-
4-methoxybenzophenone-5-sulfonate, 4-
Phenylbenzophenone, 2-ethylhexyl-4'-
Phenyl-benzophenone-2-carboxylate, 2
-Hydroxy-4-n-octoxybenzophenone, 4
-Hydroxy-3-carboxybenzophenone

(6) Other ultraviolet absorbers 3- (4'-methylbenzylidene) -d, 1-camphor;
3-benzylidene-d, 1-camphor, urocanic acid,
Urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole,
2- (2'-hydroxy-5'-methylphenyl) benzotriazole, dibenzarazine, dianisoylmethane,
4-methoxy-4'-t-butyldibenzoylmethane,
5- (3,3-dimethyl-2-norbornylidene) -3-
Pentan-2-one,

[0014] Here, ultraviolet absorption to be added to a skin external preparation containing as an active ingredient the awalussi or the squid extract to which L-ascorbic acid or a derivative thereof is added according to the present invention. The amount of the agent is not particularly limited, but is generally 0.05 to 10% by weight, preferably 0.5 to 8% by weight, based on the total amount of the external preparation for skin. If this amount is too small, sunburn cannot be prevented, and the whitening effect of awaurushi or its extract tends to be offset, which is not preferable.On the contrary, if it is too large, the stability of the external preparation for skin tends to be impaired. Is not preferred.

In addition to the essential components described above, the skin external preparation of the present invention also contains other components usually used in skin external preparations such as cosmetics and pharmaceuticals, such as oils, antioxidants, surfactants, humectants, fragrances, Water, alcohol, thickeners, preservatives, coloring agents, powders, chemicals, and the like can be appropriately added as necessary.
The dosage form of the external preparation for skin according to the present invention is arbitrary, and for example, it can take any dosage form such as a solubilizing system such as a lotion, an emulsion system such as a milky lotion or a cream, or an ointment or a dispersion. .

Next, the external preparation for skin of the present invention in which allantoin derivative is blended with ouwarushi or its extract to which L-ascorbic acid or its derivative is added, will be described. Examples of the allantoin derivatives used here include dihydroxyaluminum allantoinate, chlorohydroxyaluminum allantoinate and the like. In practicing the present invention, one or more of allantoin and its derivatives may be appropriately selected and blended. The compounding amount is 0.01 to 5.0% by weight, preferably 0.1 to 3.0% by weight, based on the total amount of the external preparation for skin.

The topical skin preparation of the present invention is used in combination with allantoin or a derivative thereof, and awaurushi or an extract thereof containing L-ascorbic acid or a derivative thereof. However, it was found that the healing was remarkably promoted. In addition, according to the present invention, an excellent wound healing effect can be obtained even when a base that acts to suppress wound healing is used. Therefore,
The formulation of the external preparation for skin applied for the purpose can be easily prepared by selecting and using a desired base, and the production is also easy. L
-The skin external preparation of the present invention in which Aluton or its derivative is added to Astragalus or its extract, and Aryton or its derivative is added, a surfactant, an oil, a wetting agent,
UV absorbers, antioxidants, preservatives, humectants, fragrances,
Water, an alcohol agent, a chelating agent, a pH adjuster, a thickener and the like can be appropriately compounded as needed. The external preparation for skin of the present invention is a nourishing cream, a cream such as a hand cream, a body cream, a massage cream, a nourishing milk,
Skin preparations for external use, such as packs and lotions,
It is also useful as an external preparation for the skin, such as a treatment for the hair, particularly for the scalp (scalable).

Next, pantethine was added to L. astragali or an extract thereof to which L-ascorbic acid or a derivative thereof was added.
The external preparation for skin of the present invention containing S-sulfonic acid (hereinafter, referred to as PSS) or a salt thereof will be described. PSS is
A known compound represented by the following general formula (1), which is naturally present in carrots, is known as a factor that promotes the growth of Bifidobacterium, and is also known to have a whitening effect itself. ing.

HOCH ₂ C (CH ₃ ) ₂ CH (OH) CONHCH ₂ CH ₂ CONHCH ₂ CH ₂ SSO ₃ H (1)

The PSS can be used in the form of a salt in addition to the free acid. Examples of the salt include a wide range of organic acid salts and inorganic acid salts, and alkali metal salts and alkaline earth metal salts are preferable.

In the present invention, the above-mentioned PSS or a salt thereof is 1: 0.1 or more, preferably 1: 1, in a weight ratio with respect to var.
0.1 to 1:10, particularly preferably 1: 0.5 to 1: 5. If the weight ratio of PSS or a salt thereof to varium is less than 0.1, the stabilizing effect is insufficient, which is not preferable.

The external preparation for skin of the present invention may contain, in addition to the above-mentioned awaurushi and PSS or a salt thereof, various components generally used in cosmetics, pharmaceuticals, etc., ie, water-producing components, powder components, surfactants, humectants, and the like. Thickeners, preservatives, ultraviolet absorbers, coloring agents, drugs, fragrances and the like can be added. Of course, these must be used within a quantitative and qualitative range that does not impair the effects of the present invention. Further, the dosage form of the external preparation for skin of the present invention is arbitrary, and any dosage form conventionally used for this type of external preparation for skin may be used, for example, ointment, cream, emulsion, lotion and the like.

[0023]

First, the efficacy of the external preparation for skin according to the present invention described above will be described in order of the composition in which an ultraviolet absorber is blended with awaurushi, the one in which allantoin is blended in awaurushi, and the one in which PSS is blended with awaurushi. I do. The skin external preparation of the present invention in which an ultraviolet absorber is mixed with L. ascorbic acid or a derivative thereof to which L-ascorbic acid or a derivative thereof is added. Was evaluated.

(1) Whitening Effect A method expressed as a ratio (inhibition rate) of inhibiting oxidase tyrosinase, which is generally used as a melanin-producing melanin, was used as an index of whitening effect. The tyrosinase inhibition rate was determined by the following procedure using dopa as a substrate. Sample solution: 150, 300 and 600 m
An M concentration aqueous solution was prepared. Substrate solution: prepared by dissolving 5 mg of dopa in 10 ml of distilled water. Enzyme solution: Tyrosinase (2000 units / mg, Sigma) 10
mg was dissolved in distilled water to prepare 10 ml. Measurement: 0.5 ml of the substrate solution and 0.9 ml of a 1/15 M phosphate buffer solution were added to 0.05 ml of the sample, 0.05 ml of the enzyme solution incubated at 25 ° C. for 5 minutes was added, and the mixture was reacted for 1.5 minutes. The absorbance at 475 nm was measured. . The inhibition rate was calculated from the measured value of the absorbance by the following equation. Inhibition rate = [1- (TT ′) / (CC ′)] × 100
(%) Where: T: absorbance when an inhibitor is added, T ': absorbance when an inhibitor is added and no substrate is added, C: absorbance when an inhibitor is not added, and C': inhibitor Table 1 shows the results of the absorbance in the case where neither the substrate nor the substrate was added, and the inhibition ratio thus obtained.

[0025]

[Table 1]

From the above results, it can be seen that compared with hydroquinone, eucalyptus has a remarkable inhibitory effect.

(2) Cumulative skin irritation The backs of white guinea pigs (5 animals per group) were shaved and shaved, and then 1%, 5%, 10% and 20% of awaurushi extract and hydroquinone monocaprylate (however, , Water mulberry extract only) in ethanol water (1: 1)
50 μl of the solution (solution or suspension) was applied once a day for 4 days, and the presence or absence of irritation was visually determined every day.
The results were as shown in Table 2. The numbers in Table 2 represent the number of guinea pigs in which the stimulus appeared.

[0028]

[Table 2]

As is clear from the results in Table 2, it can be seen that hydroquinone monocaprylate has a strong irritation, whereas Uwaurushi extract has a particularly low irritation.

(3) Contact sensitization Test method: Using a healthy guinea pig weighing 370 to 420 g, the method of Sato et al. (Sato Y., Katsumura Y. Ichikawa HK)
obayashi T.et “A Modified Technique of Guinea Pig
Testing to Identity Delayed Hypersensitivity Alle
rgens "ContactDermatitis 7,225-237,1981).

Judgment Criteria: (A) Erythema and Crust Formation State Score No erythema at all 0 Somewhat erythema is observed 1 Something with obvious erythema 2 Something with moderate erythema 3 Intense erythema with slight eschar 4

(B) Formation of edema Evaluation of edema No edema observed 0 Slight edema observed 1 Moderate edema observed 2 Strong edema observed 3

Samples: Hydroquinone, Uwaurushi extract and hydroquinone monocaprylate were as shown in Table 3. As is clear from the results in Table 3, the strength of the contact sensitization is in the order of hydroquinone mocaprylate> hydroquinone >> uwaurushi, and it is clear that the sensitization of uwaurushi is remarkably low.

[0034]

[Table 3]

(4) Stability over time Dissolve hydroquinone, awaurushi extract and hydroquinone monocaprylate at a concentration of 1 mM in a 0.1 N aqueous sodium hydroxide solution, and measure the change over time in the degree of coloration at 37 ° C.
The absorbance was measured at 420 nm. The results are shown in FIG.
In FIG. 1, curve (1) shows the change in absorbance over time of awaurushi, curve (2) shows the change in absorbance of hydroquinone, and curve (3) shows the change over time in the absorbance of hydroquinone mocaprylate. As is clear from FIG. 1, hydroquinone is rapidly colored, whereas hydroquinone monocaprylate is quite stable.
However, it is clear that the umulus are more stable and do not color at all.

Next, in order to confirm the stability in the formulation system, a stability experiment was carried out using a neutral cream of Example 3 described later. That is, Table 4 shows the degree of coloring after storing three samples at 37 ° C. for one month, two months, and three months, except that the samples were prepared by substituting hydroquinone and hydroquinone mocaprylate for awaluushi in Examples described later. As is evident from Table 4, the stability of the umbrella according to the present invention over time is extremely good.

[0037]

[Table 4]

Next, an external preparation for skin prepared by mixing allantoin with awalussi or its extract to which L-ascorbic acid or its derivative of the present invention is added will be described. Since this external preparation for skin has an excellent wound healing promoting effect, it can be suitably used after shave, after shampooing, on the scalp, cracks, cracks, and rough skin damaged by nails.

Hereinafter, the effects of the three types of skin external preparations according to the present invention, which are formulated with ouarushi and allantoin, such as whitening effect, wound healing promotion effect, and skin roughening improvement effect, will be specifically described with reference to examples. The present invention is not limited to these examples.

Example 1 Test Method Wistar rats (SPF) 6 weeks old were grouped in groups of four and subjected to a test after shaving. After anesthesia with Nembutal, the rat was cut along the midline along the midline, about
Immediately, the incision was sutured with a Michel suture device. After suturing, the incision was painted with 0.1 ml of the test once a day for two weeks. Two weeks later, the rat was killed, and after removing the suture needle, a skin section was prepared so as to have a cross section of 1 cm. For the measurement of the tension, the cutting tension of the skin section was measured using Tensilon UTM-4 (manufactured by Toyo Keiki Co., Ltd.). In addition,
As a control, physiological saline was used, and in Examples and Comparative Examples, a mixture of allantoin and awaurushi in the amounts shown in the following table was used. Table 5 shows the results.

[0041]

[Table 5]

From the results in Table 5, it can be seen that the tension applied to the 0.1% and 1.0% allantoin-applied sites was higher than the non-applied site (control), and the effect of promoting the repairing power was recognized.
%, 10.0% application showed almost no increase in tension. On the other hand, in the case of the product of the present invention in which ouwarushi and allantoin were used in combination, the tension tended to increase, and a remarkable healing promoting effect was observed, as compared with the comparative product applied alone. In addition to the animal experiments described above, in the case of a human body panel, the combination system of awalus and allantoin and / or a derivative thereof showed an effect equivalent to the result of this animal test.

Example 2 Lotion A lotion was prepared according to the following formulation by a conventional method. Propylene glycol 5.0 Ethanol 14.0 POE (20) Oleyl ether 0.5 Ouarushi extract 21.0 Allantoin 0.01 Methyl paraben 0.1 Citric acid 0.01 Sodium citrate 0.1 Perfume 0.05 Ion exchange water Residue

Example 3 Cream A cream was produced according to the following formula by a conventional method. Propylene glycol 5.0 Beeswax 4.0 Cetyl alcohol 5.0 Reduced lanolin 5.0 Squalane 36.0 Glyceryl monostearate 2.0 POE (20) sorbitan monolaurate 2.0 Methyl paraben 0.1 Ethyl paraben 0.15 Hydroquinone-β-D-arabinose 1.0 Allantoin 3.0 Fragrance 0.1 Ion exchange water Residue

Example 4 Pack A pack was produced according to the following formulation by a conventional method. Polyvinyl alcohol 16.0 Polyethylene glycol 4.0 Propylene glycol 7.0 Ethanol 11.0 Methyl paraben 0.1 Uwaurushi 7.0 Dihydroxyaluminum allantoinate 3.0 Perfume 0.1 Ion exchange water Residue

Example 5 Scalb Treatment (Scalp Cosmetic) A scalb treatment was produced by a conventional method according to the following formulation. 1,3 butylene glycol 6.0 polyethylene glycol 4.0 ethanol 11.0 POE (60) hydrogenated castor oil 2.0 caustic potash 0.05 carboxyvinyl polymer 0.2 2-hexyldecyl palmitate 11.0 squalane 5.0 beeswax 0.5 awaurushi 10.0 allantoin 4.0 preservative 0.2 flavoring 0.1 ion exchange water residue

Example 6 Ointment Vaseline 40.0 Stearyl alcohol 15.0 Wood wax 15.0 POE (10) oleate 0.25 Glyceryl monostearate 0.25 Uwaurushi 6.0 Allantoin 1.0 Sorbitol 5.0 Provylene glycol 5.0 Ion-exchanged water Residue

Finally, pantethine-added to awalussi or extract to which L-ascorbic acid or a derivative thereof has been added.
An example of the skin external preparation of the present invention containing S-sulfonic acid will be described. Note that the present invention is not limited by this description. In the following, the compounding amount is weight%.
It is.

Example 7 Lotion (Alcohol Phase) 95% Ethanol 26 Polyoxyethylene (60) Hardened Castor Oil 2 Preservatives Appropriate Perfume Appropriate (Aqueous Phase) Uwaurushi 1 PSS Calcium Salt 0.2 Glycerin 5 Ion Exchange Water Residue (Preparation Method) Water Phase and alcohol phase are adjusted and solubilized.

Example 8 Cream Stearic Acid 4 Stearyl Alcohol 4 Butyl Stearate 4 Glycerin Monostearate 2 Propylene Glycol 12 Uwaurushi 3 PSS Potassium Salt 5 Caustic Potassium 0.2 Preservatives Appropriate Perfume Appropriate Ion-exchanged Water Residue (Preparation method) Add Uwaurushi, PSS potassium salt, propylene glycol and caustic potash, dissolve and heat to maintain at 70 ° C (aqueous phase). Mix the other ingredients, heat and melt to keep at 70 ° C (oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to allow the reaction to proceed. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 9 Emulsion Stearic acid 3 Cetyl alcohol 2 Vaseline 5 Liquid paraffin 10 Polyoxyethylene (10) monooleate 2 Polyethylene glycol 1500 3 Triethanolamine 1 Uwaurushi 5 PSS sodium salt 10 Ion exchange water Residual perfume Appropriate preservative Adequate amount (Preparation method) Add awaurushi, PSS sodium salt, polyethylene glycol and triethanolamine to ion-exchanged water, dissolve by heating, and maintain at 70 ° C (aqueous phase). Mix other components, heat and maintain at 70 ° C (oil phase). The oil phase is added to the water phase, preliminarily emulsified, homogenized uniformly with a homomixer, and cooled to 30 ° C. while stirring.

Example 10 Water Absorbing Ointment Vaseline 45 Stearyl Alcohol 20 Mokurou 20 Polyoxyethylene (10) Monooleate 0.25 Glycerin Monostearate 0.25 Uwaurushi 5 PSS Calcium Salt 2 Deionized Water Residue (Preparation Method) , PSS calcium salt and maintain at 70 ° C. (aqueous phase). Other components are mixed and dissolved at 70 ° C (oil phase). The oil phase is added to the water phase, and the mixture is uniformly emulsified by a homomixer and then cooled.

(Comparative Experiment) The cosmetic of Example 7 obtained by the present invention was compared with the conventional cosmetic and the comparative cosmetic for light stability.

<Discoloration Test> Sample: (A) Lotion of Example 7 of the present invention (A) Lotion of a conventional product in which PSS calcium salt was removed (increased amount of water) from the lotion of Example 7 of the present invention (C) A comparative lotion in which the PSS calcium salt in the lotion of Example 7 of the present invention was replaced with tocopherol acetate.

Experimental Method 10 g of each sample was separately weighed into a 20-ml screw tube, and three samples were prepared for each sample.
A xenon lamp was irradiated for 16 hours at 25 ° C. Xenon lamp uses Shimadzu Xenon tester XF-60S type,
The amount of light energy received on the sample surface at a lamp power of 5 kW is about 12
00 μW / mm ² / sec, and its wavelength is close to that of sunlight. Next, the color depth of each sample after light irradiation was measured by the Gardner method, and the degree of discoloration was examined by comparing it with a sample not irradiated with light. The average value of each sample is shown in Table 6. The numerical values in the table are Gardner numbers, and the larger the numerical value, the deeper the coloring.

[0056]

[Table 6]

As shown in the results in Table 6, the coloring of the cosmetics of the present invention was remarkably suppressed and was at a level having no practical problem, whereas the cosmetics of the conventional product and the comparative product were considerably colored. Has progressed to a level that impairs product value.

<Residual rate test> Sample: The product of the present invention which is the same as that used in the discoloration test (A)
And a conventional product (a) and a comparative product (c).

Experimental Method 1 g of each sample was added to each sample (a sample not irradiated with light and a sample irradiated with light, and 3 samples per sample).
A 10 ml sample was used as a sample for HPLC, and the amount of awalus was quantified by high performance liquid chromatography, and the residual ratio was determined by the following formula. The average value of the three samples is shown in Table 7.
The higher the survival rate of awaurushi, the better the stability.

[0060]

(Equation 1)

[0061]

[Table 7]

As shown in the results in Table 7, the cosmetics of the present invention have a stable ouwarushi and a sufficient amount remains under the conditions of receiving light such as sunlight or fluorescent light.
It was proved that the effect of improving skin pigmentation could be sufficiently exhibited.

As described above, by forming an external preparation for the skin by combining awaurushi with PSS or a salt thereof, it is excellent in stability without discoloration or decomposition over time, and excellent in the effect of improving skin pigmentation. Skin external preparation can be provided. Furthermore, the whitening effect inherent to PSS or a salt thereof can also be used.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A61K 7/00 A61K 7/00 W 7/42 7/42 A61P 17/00 31/00 617 A61K 31/165 31/165 31/375 31/375 35/78 35/78 CF term (reference) 4C083 AA082 AA111 AA112 AB032 AB052 AC012 AC022 AC072 AC102 AC122 AC132 AC182 AC242 AC302 AC352 AC422 AC432 AC482 AC542 AC681 AC682 AC781 AC782 AD042 AD092 AD202 AD512 AD641 BB60 CC02 CC05 CC33 DD22 EE06 EE16 4C086 AA02 BA18 BC38 GA17 MA02 MA04 MA63 ZA89 ZB21 ZC01 4C088 AB21 AC06 BA08 MA02 MA03 MA28 NA05 ZA89 ZB21 ZC01 4C206 AA01 GA05 MA02 MA04 MA13 MA48 MA83 ZA89 ZB21 ZC01

Claims (1)

[Claims] Claims: 1. A solution of L. astragali plus L-ascorbic acid or a derivative thereof, or L. ascorbic acid extract and L.
-Ascorbic acid or a derivative thereof added with at least one selected from the group consisting of an ultraviolet absorber, allantoin or a derivative thereof, pantethine-S-sulfonic acid or a salt thereof, and An external preparation for skin, characterized in that: