JP5019885B2 - Dispersion composition, cosmetic for skin care, and method for producing dispersion composition - Google Patents

Description

  The present invention relates to a dispersion composition, a skin care cosmetic, and a method for producing the same, and in particular, a dispersion composition in which a carotenoid-containing oil-soluble component is dispersed in an aqueous composition, a skin care cosmetic using the same, and the dispersion composition. The present invention relates to a method for manufacturing a product.

  Carotenoids are naturally occurring yellow to red terpenoid pigments that can be found in plants, algae, and bacteria. Astaxanthins (including astaxanthin and its esters), which are a kind of carotenoids, are widely distributed in the animal and plant kingdoms in nature, and are mainly used as coloring agents for farmed fish and poultry. It is also known that astaxanthin has functions such as an antioxidant effect, an anti-inflammatory effect (Patent Document 1), an anti-skin aging effect (Patent Document 2), and a stain and wrinkle formation preventing effect (Patent Document 3). It has been. For this reason, it has been studied and practiced to add astachitin sun to foods, cosmetics, raw materials for pharmaceuticals, processed products thereof, and the like.

Thus, when carotenoids are added to foods, cosmetics, pharmaceuticals, and other processed products, they are often added as highly dispersible emulsion compositions. However, carotenoids derived from natural products are not suitable. In addition, it was a stable structure, and it was not easy to maintain high dispersion stability for a relatively long period of time within a range where the particle diameter of the emulsion particles was satisfactory.
In order to solve this problem, for example, Patent Documents 4 and 5 describe techniques for examining the dispersion stability of carotenoid pigments.

JP-A-2-49091 Japanese Patent Application Laid-Open No. 5-15536 JP-A-2005-47860 Japanese Patent Laid-Open No. 9-328419 JP 2005-506841 gazette

However, even in the above-described technique, the dispersion, color, and properties of the aqueous dispersion containing carotenoids may be impaired over time, and the stability of the dispersion composition containing carotenoids should be maintained over a desired period. It was difficult.
An object of the present invention is to provide a dispersion composition containing a carotenoid-containing oil-soluble component and excellent in storage stability, and a skin care cosmetic using the same.

The dispersion composition of the present invention is a dispersion composition containing a carotenoid-containing oil-soluble component, an aqueous dispersion having emulsion particles containing a carotenoid-containing oil-soluble component and a phospholipid or a derivative thereof, and ascorbic acid or a derivative thereof. And it has emulsion particles with an average particle diameter of 200 nm or less obtained by mixing with an aqueous composition containing 20% by mass or less of an oily component with respect to the total mass of the dispersion composition.
The skin care cosmetic of the present invention is characterized by containing the above dispersion composition.
The method for producing a dispersion composition of the present invention is a method for producing a dispersion composition containing a carotenoid-containing oil-soluble component, wherein the emulsion is prepared by mixing a carotenoid-containing oil-soluble component and a phospholipid or a derivative thereof with an aqueous phase. Obtaining an aqueous dispersion having particles, mixing the aqueous dispersion with an aqueous composition containing ascorbic acid or a derivative thereof and an oily component of 20% by mass or less based on the total mass of the dispersion composition; Obtaining a dispersion composition having emulsion particles having an average particle diameter of 200 nm or less.

Here, in the dispersion composition, the carotenoid is preferably at least one selected from astaxanthin and esters thereof, and the carotenoid-containing oil-soluble component is preferably a Haematococcus alga extract. .
In the dispersion composition, the ascorbic acid or a derivative thereof is preferably at least one selected from magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl-2-glucoside, and sodium ascorbate.
In the dispersion composition, the water dispersion composition may further contain tocopherol.
In the said dispersion composition, it is preferable that the said phospholipid or its derivative (s) is 0.001 mass%-20 mass% with respect to the mass of the said whole water dispersion.

  According to the present invention, it is possible to provide a dispersion composition containing a carotenoid-containing oil-soluble component and excellent in storage stability, and a skin care cosmetic using the same.

The dispersion composition of the present invention comprises an aqueous dispersion having emulsion particles containing a carotenoid-containing oil-soluble component and phospholipid or a derivative thereof, ascorbic acid or a derivative thereof, and 20% by mass with respect to the total mass of the dispersion composition. The emulsion composition is obtained by mixing an aqueous composition containing the following oil component and has emulsion particles having an average particle diameter of 200 nm or less.
In the present invention, a carotenoid-containing oil-soluble component is mixed by mixing an aqueous dispersion that is an O / W emulsion having emulsion particles and containing a carotenoid-containing oil-soluble component and an aqueous composition containing ascorbic acid or a derivative thereof. The dispersion stability of the carotenoid and the color stability of the carotenoid can both be kept good, and as a result, a dispersion composition having excellent storage stability can be obtained.

  The carotenoid in the dispersion composition of the present invention includes any of plants, algae and bacteria. Moreover, it is not limited to the thing of natural origin, Any thing will be included by the carotenoid in this invention if it can be obtained in accordance with a conventional method.

Examples of carotenoids include hydrocarbons (carotenes), oxidized alcohol derivatives thereof (xanthophylls), and esters thereof. In the present invention, these compounds are referred to as “carotenoid” unless otherwise specified.
Examples of carotenoids include actinioerythrol, astaxanthin, bixin, canthaxanthin, capsanthin, capsorubin, β-8′-apo-carotenal (apocarotenal), β-12′-apo-carotenal, α-carotene, β-carotene , “Carotene” (a mixture of α- and β-carotenes), γ-carotene, δ-carotene, β-cryptoxanthin, echinone, palm oil carotene, lutein, lycopene, biorelithrin, zeaxanthin, and among them hydroxyl or carboxyl The ester of what contains is mentioned.

Many of these carotenoids occur naturally in the form of cis and trans isomers, but in the case of synthetics also include racemic mixtures.
Carotenoids can generally be extracted from plant material. These carotenoids have a variety of functions, for example, lutein extracted from marigold petals is widely used as a raw material for poultry food, and functions to color poultry skin and fat and eggs produced by poultry There is.
The content of the carotenoid in the aqueous dispersion is a relatively high concentration from the viewpoint of satisfactorily exerting the carotenoid-containing functional effect when the dispersion composition is formed, preferably 0.1 to 10% by mass, more preferably Is 0.2 to 5 mass%, more preferably 0.5 to 2 mass%.

The carotenoid used in the present invention is preferably oily at normal temperature from the viewpoint of minimizing the organic medium used during dispersion. A particularly preferred example is astaxanthin, which is known as a colorant in the yellow to red range.
Astaxanthin is a red pigment with absorption maxima at 476 nm (ethanol) and 468 nm (hexane) and belongs to a kind of carotenoid xanthophyll (Davies, BH: In “Chemistry and Biochemistry of Plant Pigments”, TW Goodwin ed., 2nd. ed., 38-165, Academic Press, NY, 1976.). The chemical structure of astaxanthin is 3,3′-dihydroxy-β, β-carotene- ₄ , 4′-dione (C ₄₀ H ₅₂ 0 ₄ , molecular weight 596.82).
In the present invention, the term “astaxanthin” includes the above-mentioned derivatives such as astaxanthin and astaxanthin ester unless otherwise specified.

  Astaxanthin is a 3S, 3S′-form, 3S, 3R′-form (meso-form), 3R in which isomers exist due to the configuration of the hydroxyl groups at the 3 (3 ′)-position of the ring structure present at both ends of the molecule. , 3R′-isomers, and cis- and trans-isomers of conjugated double bonds at the center of the molecule. For example, all cis-, 9-cis and 13-cis isomers.

  The hydroxyl group at the 3 (3 ')-position can form an ester with a fatty acid. Astaxanthin obtained from krill is a diester (Yamaguchi, K., Miki, W., Toriu, N., Kondo, Y., Murakami, M., Konosu, S., Satake, M., Fujita). , T .: The composition of carotenoid pigments in the antarctic krill Euphausia superba, Bull. Jap. Sos. Sci. Fish., 1983, 49, p.1411-1415.), H. pluvialis can be obtained from 3S, 3S '-Body, which contains many monoesters with one fatty acid (Renstrom, B., Liaaen-Jensen, S .: Fatty acids of some esterified carotenols, Comp. Biochem. Physiol. B, Comp. Biochem. , 1981, 69, p.625-627.).

  Astaxanthin obtained from Phaffia Rhodozyma is a 3R, 3R′-form (Andrewes, AG, Starr, MP: (3R, 3′R) -Asttaxanthin from the yeast Phaffa rhodozyma, Phytochem., 1976, 15, p.1009. -1011.) And has the opposite structure to the 3S, 3S′-form normally found in nature. It also exists in free form that does not form esters with fatty acids (Andrewes, AG, Phaffia, HJ, Starr, MP: Carotenids of Phaffia rhodozyma, a red pigmented fermenting yeast, Phytochem., 1976, 15, p. .1003-1007.)

  Astaxanthin and its ester are R.I. Kuhn et al. First isolated from lobster (Astacus gammarus L.) and disclosed its putative structure (Kuhn, R., Soerensen, NA: The coloring matters of the lobster (Astacus gammarus L.), Z. Angew. Chem. , 1938, 51, p.465-466.). Since then, it has been clarified that astaxanthin is widely distributed in nature and usually exists as an astaxanthin fatty acid ester, and also exists as an astaxanthin protein (oborbin, cluster cyanine) bound to proteins in crustaceans (Cheesman , DF: Ovorubin, a chromoprotein from the eggs of the gastropod mollusc Pomacea canaliculata, Proc. Roy. Soc. B, 1958, 149, p.571-587.).

The astaxanthin and the ester of astaxanthin (astaxanthins) may be contained in the aqueous dispersion and the dispersion composition of the present invention as an astaxanthin-containing oil separated and extracted from a natural product containing astaxanthin and / or its ester. Examples of such astaxanthin-containing oils include red yeast Phaffia, green algae hematococcus, marine bacteria, and the like, and extracts from the culture, extracts from Antarctic krill, and the like.
Astaxanthin has two hydroxyl groups in the molecule, Haematococcus alga extract (Haematococcus alga-derived dye) is monoester is the main component, krill-derived dyes, in terms diester as a main component It is known to be different.

  Astaxanthin that can be used in the present invention may be the above-described extract, a product obtained by appropriately purifying the extract as necessary, or a synthetic product. As the astaxanthin, those extracted from Haematococcus alga (hereinafter also referred to as Haematococcus alga extract) are particularly preferred from the viewpoint of quality and productivity.

  Specific examples of the origin of the Haematococcus alga extract usable in the present invention include Haematococcus pluvialis, Haematococcus lacustris, Haematococcus capensis, Haematococcus capensis, Examples thereof include Haematococcus droebakensis and Haematococcus zimbabwiensis.

The method for culturing Haematococcus algae that can be used in the present invention can employ various methods disclosed in JP-A-8-103288 and the like, and is not particularly limited. What is necessary is just to change the form to cyst cells.
The Haematococcus alga extract that can be used in the present invention is prepared by using the above-mentioned raw materials, if necessary, by crushing the cell wall by a method disclosed in, for example, JP-A-5-68585, etc., and adding acetone, ether, chloroform, and alcohol. It can be obtained by adding an organic solvent such as (ethanol, methanol, etc.) or an extraction solvent such as supercritical carbon dioxide.

The Haematococcus alga extract contains astaxanthin or an ester thereof as the pure pigment, as in the dye described in JP-A-2-49091, and the ester is generally at least 50 mol%, preferably 75 mol. % Or more, more preferably 90 mol% or more.
In addition, in the present invention, commercially available Haematococcus alga extract can be used, for example, ASTOTS-S, -2.5O, -5O, -10O, etc., manufactured by Takeda Shiki Co., Ltd. Examples include Asteryl Oil 50F and 5F manufactured by Fuji Chemical Industry Co., Ltd., BioAstin SCE7 manufactured by Toyo Enzyme Chemical Co., Ltd., and the like.
In the present invention, the content of astaxanthin in the Haematococcus alga extract as a pure pigment content is preferably 0.001% by mass to 50% by mass, more preferably 0.01% by mass to 25% by mass. .
Moreover, 0.001 mass%-20 mass% are preferable from a viewpoint of the stability of a dispersion, and, as for the compounding quantity as an astaxanthin containing oil in an aqueous dispersion, it is still more preferable that it is 0.1 mass%-10 mass%.

The phospholipid in the present invention is an ester composed of fatty acid, alcohol, phosphoric acid and nitrogen compound among complex lipids, and is a group having phosphate ester and fatty acid ester, glycerophospholipid not containing glycerin, sphingoline containing sphingosine It refers to lipid.
Specific examples of the phospholipid used in the present invention include phosphatidic acid, bisphosphatidic acid, lecithin (phosphatidylcholine), phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, diphosphatidylglycerol, and sphingomyelin. Examples thereof include those derived from plants such as soybeans, corn, peanuts, rapeseed, and wheat, those derived from animals such as egg yolk and cows, and various lecithins derived from microorganisms such as E. coli. it can. A mixture of these, lecithin and hydrogenated lecithin can also be used. The origin of these phospholipids is not particularly limited. For example, vegetable oils such as soybean oil, those derived from animals such as egg yolk, etc. are used, and particularly purified ones are preferred.

In the present invention, the glycerophospholipid includes glycerophospholipid having one fatty acid residue in one molecule, that is, lysolecithin as a result of enzymatic degradation.
Such lysolecithin can be obtained by hydrolysis of lecithin with an acid or alkali catalyst, but can also be obtained by hydrolysis of lecithin with phospholipase A ₁ or A ₂ .
Examples of such lysolecithin include lysophosphatidic acid, lysophosphatidylglycerin, lysophosphatidylinositol, lysophosphatidylethanolamine, lysophosphatidylmethylethanolamine, lysophosphatidylcholine (lysolecithin), lysophosphatidylserine and the like.

Furthermore, as glycerophospholipid represented by the above lecithin, hydrogenated or hydroxylated one can also be used in the present invention. For example, hydrogenated lecithin, enzymatically decomposed lecithin, enzymatically decomposed hydrogenated lecithin, hydroxylecithin Etc. can be used.
The hydrogenation is performed, for example, by reacting lecithin with hydrogen in the presence of a catalyst, and the unsaturated bond of the fatty acid moiety is hydrogenated. Hydrogenation improves the oxidation stability of lecithin.
Moreover, the said hydroxylation heats a lecithin with high concentration hydrogen peroxide and organic acids, such as an acetic acid, tartaric acid, and butyric acid, and the unsaturated bond of a fatty-acid part is hydroxylated. Hydroxylation improves the hydrophilicity of lecithin.

In the present invention, lecithin is particularly preferable from the viewpoint of emulsion stability.
Examples of commercially available lecithins include the Riken series manufactured by Riken Vitamin Co., Ltd. and Recimar EL.

Although the lecithin having a purity of 60% by mass or more is industrially used as lecithin, in the present invention, a lecithin having a purity of 80% by mass or more generally called “high purity lecithin” is preferable. Preferably it is 90 mass% or more.
The lecithin purity (mass%) is determined by subtracting the weight of the toluene insoluble matter and the acetone soluble matter by utilizing the property that lecithin is easily dissolved in toluene and not dissolved in acetone. High purity lecithin, high lipophilicity compared to lysolecithin, therefore increases the compatibility of the lecithin and the oily component is preferable since capable of improving emulsion stability.
The phospholipid used in the present invention can be used alone or in the form of a mixture of plural kinds.

  The phospholipid content in the aqueous dispersion in the present invention is preferably from 0.001% by mass to 20% by mass, more preferably from 0.001 to 10%, based on the aqueous dispersion, from the viewpoint of emulsion stability. % By mass.

  The water-soluble emulsifier that can be used in the aqueous dispersion according to the present invention is not particularly limited as long as it is an emulsifier that dissolves in an aqueous medium. For example, a nonionic surfactant having an HLB of 10 or more, preferably 12 or more. preferable. If the HLB is less than 10, the emulsifying power may be insufficient. From the viewpoint of emulsion stability, the HLB is preferably 16 or less.

Here, HLB is a hydrophilic-hydrophobic balance that is usually used in the field of surfactants, and a commonly used calculation formula such as the Kawakami formula can be used. In the present invention, the Kawakami equation is adopted.
HLB = 7 + 11.7log (Mw / Mo)
Here, Mw is the molecular weight of the hydrophilic group, and Mo is the molecular weight of the hydrophobic group.
Moreover, you may use the numerical value of HLB described in the catalog etc.
Further, as can be seen from the above formula, an emulsifier having an arbitrary HLB value can be obtained by utilizing the additivity of HLB.

  The emulsifier that can be used in the present invention is not particularly limited, but a nonionic emulsifier is preferable. Examples of nonionic emulsifiers include glycerin fatty acid esters, organic acid monoglycerides, polyglycerin fatty acid esters, propylene glycol fatty acid esters, polyglycerin condensed ricinoleic acid esters, sorbitan fatty acid esters, and sucrose fatty acid esters. More preferred are polyglycerin fatty acid esters, sorbitan fatty acid esters, and sucrose fatty acid esters. The emulsifier is not necessarily highly purified by distillation or the like, and may be a reaction mixture.

  The polyglycerin fatty acid ester used in the present invention has an average degree of polymerization of 2 or more, preferably 6 to 15, more preferably 8 to 10 and fatty acid having 8 to 18 carbon atoms, such as caprylic acid and caprin. Esters with acids, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, and linoleic acid. Preferred examples of polyglycerol fatty acid esters include hexaglycerol monooleate, hexaglycerol monostearate, hexaglycerol monopalmitate, hexaglycerol monomyristate, hexaglycerol monolaurate, decaglycerol monooleate , Decaglycerin monostearic acid ester, decaglycerin monopalmitic acid ester, decaglycerin monomyristic acid ester, decaglycerin monolauric acid ester and the like. These polyglycerin fatty acid esters can be used alone or in combination. Commercially available products include, for example, Nikko Chemicals Co., Ltd., NIKKOL DGMS, NIKKOL DGMO-CV, NIKOL DGMO-90V, NIKKOL DGDO, NIKKOL DGMIS, NIKKOL DGTI, NIKKOL DGTIS, NIKKOL DGTI Tetraglyn 3-S, NIKKOL Tetraglyn 5-S, NIKKOL Tetraglyn 5-O, NIKKOL Hexaglyn 1-L, NIKKOL Hexaglyn 1-M, NIKKOL Hexaglyn 1-SV, NIKKOL Hexaglyn 1-O, NIKKOL Hexaglyn 3-S, NIKKOL Hexaglyn 4 -B, NIKKOL Hexa lyn 5-S, NIKKOL Hexaglyn 5-O, NIKKOL Hexaglyn PR-15, NIKKOL Decaglyn 1-L, NIKKOL Decaglyn 1-M, NIKKOL Decaglyn 1-SV, NIKKOL Decaglyn 1-50SV, NIKKOL Decaglyn 1-ISV, NIKKOL Decaglyn 1 -O, NIKKOL Decaglyn 1-OV, NIKKOL Decaglyn 1-LN, NIKKOL Decaglyn 2-SV, NIKKOL Decaglyn 2-ISV, NIKKOL Decaglyn 3-SV, NIKKOL Decaglyn 3-OV, NIKKOL Decaglyn 5-SV, NIKKOL Decaglyn 5-H , NIKKOL Decaglyn 5-IS, NIKKOL Decaglyn 5-OV, NIKKOL Decaglyn 5-O-R, NIKKOL Decaglyn 7-S, NIKKOL Decaglyn 7-O, NIKKOL Decaglyn 10-SV, NIKKOL Decaglyn 10-IS, NIKKOL Decaglyn 10-OV , NIKKOL Decaglyn 10-MAC, NIKKOL Decaglyn PR-20, Ryoto polyglycerate L-10D, L-7D, M-10D, M-7D, P-8D, S-28D, S, manufactured by Mitsubishi Chemical Foods Co., Ltd. -24D, SWA-20D, SWA-15D, SWA-10D, O-50D, O-15D, B-100D, B-70D, ER-60D, solarization Examples include Sunsoft Q-17UL, Sunsoft Q-14S, Sunsoft A-141C, and Poem DO-100, Poem J-0021 manufactured by Riken Vitamin Co., Ltd.

  The sorbitan fatty acid ester used in the present invention preferably has 8 or more carbon atoms, more preferably 12 or more. Preferable examples of sorbitan fatty acid esters include sorbitan monocaprylate, sorbitan monolaurate, sorbitan monostearate, sorbitan tristearate, sorbitan tristearate, sorbitan isostearate, sorbitan sesquiisostearate, sorbitan oleate, sorbitan sesquioleate And sorbitan trioleate. These sorbitan fatty acid esters can be used alone or in combination. As a commercial item, Nikko Chemicals Co., Ltd. make, NIKKOL SL-10, SP-10V, SS-10V, SS-10MV, SS-15V, SS-30V, SI-10RV, SI-15RV, SO-15 10V, SO-15MV, SO-15V, SO-30V, SO-10R, SO-15R, SO-30R, SO-15EX, manufactured by Daiichi Kogyo Seiyaku Co., Ltd., Sorgen 30V, 40V, 50V, 90, 110 or the like.

  The sucrose fatty acid ester used in the present invention preferably has a fatty acid having 12 or more carbon atoms, more preferably 12-20. Preferred examples of sucrose fatty acid esters include sucrose dioleate, sucrose distearate, sucrose dipalmitate, sucrose dimyristic ester, sucrose dilaurate, sucrose monooleate, sucrose Examples thereof include sugar monostearate, sucrose monopalmitate, sucrose monomyristate, and sucrose monolaurate. In the present invention, these sucrose fatty acid esters can be used alone or in combination. Examples of commercially available products include Ryoto Sugar Esters S-070, S-170, S-270, S-370, S-370F, S-570, S-770, and S-970 manufactured by Mitsubishi Chemical Foods Corporation. , S-1170, S-1170F, S-1570, S-1670, P-070, P-170, P-1570, P-1670, M-1695, O-170, O-1570, OWA-1570, L -195, L-595, L-1695, LWA-1570, B-370, B-370F, ER-190, ER-290, POS-135, DK ester SS manufactured by Daiichi Kogyo Seiyaku Co., Ltd., F160, F140, F110, F90, F70, F50, F-A50, F-20W, F-10, F-A10E, Cosmelike B-30, S-10, S-50, S-70, -110, S-160, S-190, SA-10, SA-50, P-10, P-160, M-160, L-10, L-50, L-160, L-150A, L-160A , R-10, R-20, O-10, O-150 and the like.

  The amount of these emulsifiers added is preferably 0.1 to 50% by mass, more preferably 0.5 to 20% by mass, and still more preferably 1 to 15% by mass with respect to the aqueous dispersion. By setting the addition amount to 0.1% by mass or more, it is possible to obtain an emulsion having a finer particle size and to sufficiently ensure the stability of the emulsion, and to add 50% by mass or less. By setting the amount, foaming of the emulsion can be adjusted to an appropriate range.

The aqueous dispersion preferably further contains tocopherol as an oil-soluble component from the viewpoint of preventing carotenoids from being oxidized.
Usable tocopherols are not particularly limited and are selected from the group of compounds consisting of tocopherols or derivatives thereof.
The compound group consisting of tocopherol or its derivatives includes dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, dl-α-tocopherol acetate, nicotinic acid-dl-α-tocopherol. , Linoleic acid-dl-α-tocopherol, tocopherols such as dl-α-tocopherol succinate and derivatives thereof, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol and the like. These are often used in the form of a mixture, and can be used in a state called extracted tocopherol, mixed tocopherol or the like.
The content of tocopherol in the present aqueous dispersion is not particularly limited, but is preferably a ratio of 0.1 to 5 with respect to the amount of carotenoid, more preferably from the viewpoint of an amount effective for preventing carotenoids from being oxidized. Is a ratio of 0.2 to 3, more preferably 0.5 to 2.

In the aqueous dispersion according to the present invention, it is preferable that glycerin is contained because the average particle diameter of the emulsion particles in the aqueous dispersion can be further reduced, and the particle diameter can be stably maintained over a long period of time. .
In this case, the content of glycerin is preferably 10% by mass to 60% by mass, preferably 20% by mass to 55% by mass, more preferably 20% by mass to 55% by mass with respect to the total mass of the aqueous dispersion. Preferably they are 30 mass%-50 mass%.

Moreover, it is preferable that this water dispersion contains antioxidant.
Examples of usable antioxidants include, but are not limited to, compounds including polyphenols, radical scavengers, the aforementioned tocopherols, and the like.
As the antioxidant that can be used in the present invention, a hydrophilic antioxidant and / or an oil-soluble antioxidant can be used alone or in combination.
The content of the antioxidant in the carotenoid-containing emulsion composition of the present invention is generally 0.1% by mass to 10% by mass, preferably 0.2% by mass to 5% by mass, and more preferably 0.8%. It is 5 mass%-2 mass%.
In addition, ascorbic acid or an ascorbic acid derivative that can generally be used as an antioxidant or the like is not included in the aqueous dispersion. These compounds are contained in the aqueous composition for mixing with the aqueous dispersion as described later.

  Compound groups consisting of polyphenols that are antioxidants that can be used in aqueous dispersions include flavonoids (catechin, anthocyanin, flavone, isoflavone, flavan, flavanone, rutin), phenolic acids (chlorogenic acid, ellagic acid, gallic acid Propyl gallate), lignans, curcumins, and coumarins. Moreover, since these compounds are contained in a large amount in the following natural product-derived extracts, they can be used in the form of extracts.

  For example, licorice extract, cucumber extract, caquette extract, gentian (gentian) extract, Gentian extract, cholesterol and its derivatives, hawthorn extract, peonies extract, ginkgo biloba extract, scallop (Ogon) extract, carrot Extract, Maika (Maika, Hamanasu) extract, Sunpens (Kawara-Ketsumei) extract, Tormentilla extract, Parsley extract, Button (buttonpi) extract, Mokka (bokeh) extract, Melissa extract, Yashajitsu (Yasha) extract , Yukinoshita extract, Rosemary (mannenrou) extract, lettuce extract, tea extract (Oolong tea, black tea, green tea, etc.), microbial fermentation metabolites, Rakan fruit extract, etc. (in parentheses are plant aliases) , Herbal medicine name etc. were described.) Among these polyphenols, catechin, rosemary extract, glucosyl rutin, ellagic acid, and gallic acid are particularly preferable.

  What is generally marketed can be used suitably for the antioxidant used for this invention. For example, ellagic acid (Wako Pure Chemicals, etc.), rosemary extract (trade names RM-21A, RM-21E: Mitsubishi Chemical Foods, etc.), catechin (trade names: Sankatol W-5, No. 1: Taiyo Kagaku, etc. ), Na gallate (trade name: Sankatol: Taiyo Kagaku, etc.), rutin / glucosylrutin / enzymatic degradation rutin (trade name: rutin K-2, P-10: Kiriya Chemical, trade name αG rutin: Hayashibara Biochemical Research) Etc.).

The group of radical scavengers that can be used in the aqueous dispersion is an additive that suppresses the generation of radicals, captures the generated radicals as quickly as possible, and interrupts the chain reaction. (Source: “Oil Chemistry Handbook 4th Edition”, edited by Japan Oil Chemists' Society, 2001) As a direct method of confirming the function as a radical scavenger, it can be mixed with a reagent to capture radicals by spectrophotometry. A method of measuring by a meter or an ESR (electron spin resonance apparatus) is known. In these methods, DPPH (1,1-diphenyl-2-picrylhydrazyl) or galvinoxyl radical is used as a reagent.
In the present invention, the time required to raise the peroxide value (POV value) of fats and oils to 60 meq / kg under the following experimental conditions using the autoxidation reaction of fats and oils is twice or more that of the blank. The compound is a radical scavenger. More preferably, it is 5 times or more.
Fat and oil: Olive oil Addition amount: 0.1% by mass with respect to fat and oil
Test conditions: The sample was heated at 190 ° C., the POV value was measured over time, and the time for 60 meq / kg was calculated.

The compounds that can be used as the radical scavenger of the present invention include “theory and practice of antioxidants” (Enomoto, Sanshobo, 1984) and “Antioxidant Handbook” (Saruwatari, Nishino, Tabata, Taiseisha, 1976). Among the various antioxidants described in (1), any compound that functions as a radical scavenger may be used. Specifically, compounds having phenolic OH, amine-based antioxidants such as phenylenediamine, ascorbic acid, Examples include oil-solubilized derivatives of erythorbic acid.
Although the preferable compound is illustrated below, this invention is not limited to these.
Examples of the compound having phenolic OH include guaiac fat, nordihydroguaiaretic acid (NDGA), gallic acid esters, BHT (butylhydroxytoluene), BHA (butylhydroxyanisole), tocopherols and bisphenols. . Examples of gallic acid esters include propyl gallate, butyl gallate, and octyl gallate.
Examples of the amine compound include phenylenediamine, and diphenyl-p-phenylenediamine or 4-amino-p-diphenylamine is more preferable.

  Other oil-soluble ingredients are usually UV absorbers, antioxidants, anti-inflammatory agents, moisturizers, hair protectants, dispersants, solvents, whitening agents, anti-staining agents, cell activators, emollients, keratolytics. Other ingredients used as agents, antistatic agents, vitamins, metabolic syndrome improving agents, antihypertensives, sedatives, etc. can be used, for example, oils such as olive oil, camellia oil, macadamia nut oil, castor oil , Hydrocarbons such as liquid paraffin, paraffin, petrolatum, ceresin, microcrystalline wax, squalane, carnauba wax, candelilla wax, jojoba oil, beeswax, lanolin and other waxes, isopropyl myristate, 2-octyldodecyl myristate, 2 -Esters such as cetyl ethylhexanoate and diisostearyl malate, Fatty acids such as mitic acid, stearic acid and isostearic acid, higher alcohols such as cetyl alcohol, stearyl alcohol, isostearyl alcohol and 2-octyldodecanol, silicone oils such as methylpolysiloxane and methylphenylpolysiloxane, fatty acids of glycerin Examples include esters, other polymers, oil-soluble pigments, and oil-soluble proteins. In addition, various plant-derived oils and animal-derived oils that are mixtures thereof are also included. Other preferable oily components used in the present invention include vitamin Es (in addition to the above-mentioned tocopherol, tocotrienol, etc.), coenzyme Qs, omega-3 oils (oils and fats containing EPA, DHA, linolenic acid, etc.), etc. Can be mentioned.

In addition, an organic solvent is added to the aqueous dispersion in the present invention in order to dissolve the various oily components and other components described above and to further refine the average particle size of the emulsion particles in the aqueous dispersion. It is preferable to do.
Such an organic solvent is preferably water-soluble, and examples thereof include methanol, ethanol, isopropanol, acetone, tetrahydrofuran, acetonitrile and a mixture thereof. Among these, ethanol is preferred when considering use for foods, cosmetics and the like.
Content with respect to the aqueous dispersion of this organic solvent can be 0.1 mass%-20 mass%, for example, Preferably it can be 0.5 mass%-10 mass%.

From the viewpoint of transparency, the particle diameter of the emulsion particles in the aqueous dispersion is 200 nm or less, preferably 150 nm or less, more preferably 100 nm or less, as a volume average particle diameter (median diameter). The particles having such an average particle diameter can be easily obtained by mixing the components of the aqueous dispersion in the above-described quantitative ratio.
The particle size depends on factors such as the type and amount used of the additive component, emulsification conditions (shearing force, temperature, pressure) in the production method, the amount of additive used, the ratio of oil phase to water phase, and the amount of surfactant used. Although it varies, there is no practical problem if the particle diameter of the present invention is used.

The particle diameter can be measured with a commercially available particle size distribution meter or the like. Emulsion particle size distribution measurement methods include optical microscopy, confocal laser microscopy, electron microscopy, atomic force microscopy, static light scattering, laser diffraction, dynamic light scattering, centrifugal sedimentation, electricity A pulse measurement method, a chromatography method, an ultrasonic attenuation method, and the like are known, and apparatuses corresponding to the respective principles are commercially available.
In view of the particle size range and the ease of measurement in the present invention, the dynamic light scattering method is preferred for the emulsion particle size measurement of the present invention. As a commercially available measuring device using dynamic light scattering, Nanotrac UPA (Nikkiso Co., Ltd.), dynamic light scattering type particle size distribution measuring device LB-550 (Horiba, Ltd.), a concentrated particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.) etc. are mentioned. The measurement temperature may be any temperature usually used for measuring the particle diameter, but is preferably 20 ° C.
The particle diameter in the present invention is a value measured using the dynamic light scattering particle size distribution measuring apparatus at a measurement temperature of 20 ° C.

  Examples of the aqueous medium constituting the aqueous dispersion according to the present invention include water, and any of distilled water, ion-exchanged water, pure water, and the like can be used.

  The aqueous dispersion containing the carotenoid-containing oil-soluble component in the present invention is not particularly limited. For example, a) a water-soluble emulsifier is dissolved in an aqueous medium to obtain an aqueous phase, and b) the aforementioned carotenoid, tocopherol, It can be obtained by mixing and dissolving phospholipids and other fats and oils as necessary to obtain an oil phase, and c) mixing an aqueous phase and an oil phase with stirring, and emulsifying and dispersing.

  When emulsifying and dispersing, for example, after emulsification using a normal emulsifier using a shearing action such as a stirrer, impeller agitation, homomixer, continuous flow type shearing device, etc., two or more types are passed by a method such as passing through a high-pressure homogenizer. It is particularly preferable to use the above emulsifying apparatus together. By using a high-pressure homogenizer, the emulsion can be arranged into even more uniform droplets of fine particles. Further, it may be performed a plurality of times for the purpose of forming a droplet having a more uniform particle diameter.

  Examples of the high-pressure homogenizer include a chamber-type high-pressure homogenizer having a chamber in which a flow path for processing liquid is fixed, and a homogeneous valve-type high-pressure homogenizer having a homogeneous valve. Among these, the homogeneous valve type high-pressure homogenizer can easily adjust the width of the flow path of the processing liquid, so the pressure and flow rate during operation can be set arbitrarily, and the operation range is wide. Can be preferably used in the present invention. In addition, although the degree of freedom of operation is low, a mechanism for increasing the pressure is easy to make, and therefore a chamber type high-pressure homogenizer can be suitably used for applications that require ultra-high pressure.

Examples of the chamber type high-pressure homogenizer include a microfluidizer (manufactured by Microfluidics), a nanomizer (manufactured by Yoshida Kikai Kogyo Co., Ltd.), an optimizer (manufactured by Sugino Machine Co., Ltd.), and the like.
As the homogeneous valve type high-pressure homogenizer, Gorin type homogenizer (manufactured by APV), Lanier type homogenizer (manufactured by Lanier), high-pressure homogenizer (manufactured by Niro Soabi), homogenizer (manufactured by Sanwa Machinery Co., Ltd.), high-pressure homogenizer ( Izumi Food Machinery Co., Ltd.), ultra-high pressure homogenizer (manufactured by Ika), and the like.

  In the present invention, the pressure of the high-pressure homogenizer is preferably 50 MPa or more, more preferably 50 to 250 MPa, and still more preferably 100 to 250 MPa. Moreover, it is preferable from the viewpoint of maintaining the particle size of the dispersed particles that the emulsified liquid, which is an emulsified and dispersed composition, is cooled through some cooler within 30 seconds, preferably within 3 seconds immediately after passing through the chamber.

Next, the aqueous composition in the present invention will be described.
The aqueous composition in the present invention contains ascorbic acid or a derivative thereof.
In the present invention, ascorbic acid or a derivative thereof is contained in the aqueous composition. By mixing the aqueous composition and the aqueous dispersion containing the carotenoid-containing oil-soluble component, the discoloration of the carotenoid is suppressed, and the emulsion particles are dispersed. Both sex and color can be stabilized. Moreover, in the dispersion composition which further contains a fragrance | flavor, the fragrance | flavor property by a fragrance | flavor can be maintained favorable.
Ascorbic acid or a derivative thereof is preferably water-soluble ascorbic acid or a derivative thereof.
Examples of such ascorbic acid or ascorbic acid derivatives include ascorbic acid, sodium ascorbate, potassium ascorbate, calcium ascorbate, L-ascorbic acid phosphate, ascorbyl magnesium phosphate, ascorbyl sulfate, ascorbyl sulfate disodium salt, ascorbyl -2-glucoside and the like. In addition, erythorbic acid or a derivative thereof such as erythorbic acid, sodium erythorbate, potassium erythorbate, calcium erythorbate, erythorbic acid phosphate, erythorbic acid sulfate, etc. can also be included in the ascorbic acid or derivative thereof in the present invention.
Of these, from the viewpoints of preventing carotenoid discoloration and dispersion stability of emulsion particles, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl-2-glucoside, and sodium ascorbate are preferred, and magnesium ascorbyl phosphate and ascorbyl phosphate are preferred. Sodium is particularly preferred.

  These ascorbic acid or its derivative can use what is generally marketed suitably. For example, L-ascorbic acid (Takeda Pharmaceutical, Fuso Chemical, BASF Japan, Daiichi Pharmaceutical, etc.), L-ascorbic acid Na (Takeda Pharmaceutical, Fuso Chemical, BASF Japan, Daiichi Pharmaceutical, etc.), Ascorbic acid 2-glucoside (Product name: AA-2G: Hayashibara Biochemical Research Institute), Mg as L-ascorbate phosphate (Product name: Ascorbic acid PM “SDK” (Showa Denko), Product name: NIKKOL VC-PMG (Nikko Chemicals), Product name: Seamate (Takeda) Pharmaceutical industry)) and the like.

  Ascorbic acid or a derivative thereof may be present in the aqueous composition in an amount capable of suppressing the discoloration of the carotenoid and maintaining the dispersibility of the emulsion particles in the aqueous composition. For this reason, the amount of ascorbic acid or a derivative thereof is 0.1% by mass to less than 10% by mass, preferably 0.5% by mass to 5% with respect to the total mass of the aqueous composition from the viewpoint of preventing the decomposition of carotenoids. It can be made into the mass% or less.

  The aqueous composition according to the present invention may contain the oil-soluble component described above other than the carotenoid-containing oil-soluble component. When the oil-soluble component other than the carotenoid-containing oil-soluble component is contained, the oil-soluble component is preferably 20% by mass or less, particularly preferably 5% by mass or less, based on the total mass of the dispersion composition. preferable. An amount of 20% by mass or less in the dispersion composition is preferable because it is easy to suppress separation of the oil phase and the aqueous phase.

The aqueous composition according to the present invention may contain polyols such as glycerin, PG (propylene glycol), BG (1,3-butylene glycol), and pentylene glycol as an aqueous base material.
In addition, various water-soluble polymer compounds and water-dispersible fine particles can be included as particle stabilizers.
As the water-soluble polymer compound, any of a wide range of synthetic polymers, natural polymers, and semi-synthetic polymers can be used, and in particular, from the viewpoint of satisfactorily stabilizing carotenoid-containing oil-soluble components and the like. Saccharides, proteins and their complexes are preferred.

Examples of saccharides include, but are not limited to, monosaccharides, disaccharides, oligosaccharides, polysaccharides, dextrins, starch derivatives, gums, mucopolysaccharides, and celluloses.
Among these, representative ones are agarose, arabinose, amylose, amylopectin, acacia gum, gum arabic, arabinogalactan, alkylglycoside, alginic acid, sodium alginate, propylene glycol alginate, aldose, inulin, oligosaccharide, gati gum , Curdlan, carrageenan, galactomannan, galactose, xanthan gum, xylose, xyloglucan, chitin, chitosan, guar gum, cluster dextrin, β-glucan, glucuronic acid, glycogen, glycosaminoglycan, glyceraldehyde, glucosamine, glucose, gluco Mannan, ketose, chondroitin sulfate, psyllium seed gum, gellan gum, cyclodextrin, sucrose, hydroxyethyl Cellulose, hydroxypropylcellulose, carboxymethylcellulose, methylcellulose, cellobiose, sorbitol, deoxyribose, dextrin, invert sugar, starch, soy polysaccharide, sugar alcohol, glycoprotein, tragacanth gum, trehalose, hyaluronic acid, fucose, fructose, pullulan, pectin, Examples include heparin, hemicellulose, maltose, mannitol, mannan, lactose, and ribose, but are not limited thereto.
Among these saccharides, polysaccharides are preferable from the viewpoint of dispersion stability due to an increase in viscosity, and gum arabic and pullulan are more preferable from the viewpoint of stability of carotenoids.

Any kind of protein can be used as long as it is a polymer or oligomer in which amino acids are polymerized by peptide bonds, but it is preferably naturally derived and water-soluble.
Proteins include simple proteins composed of amino acids and complex proteins containing components other than amino acids, and both can be used. Examples of simple proteins include gelatin, collagen, casein, fibroin, sericin, keratin, protamine and the like. In addition, complex proteins include glycoproteins that bind to carbohydrates, lipoproteins that bind to lipids, metal proteins that bind to metal ions, nucleoproteins that bind to ribonucleic acid, and phosphates. There are phosphoproteins that are proteins bound to groups.
On the other hand, in general, it is often referred to as a protein raw material, and examples include animal muscle protein, milk protein, egg protein, rice protein, wheat protein (wheat gluten), soy protein, yeast protein, and bacterial protein. .
Such proteins may be used as a mixture.
Among these proteins, gelatin and water-soluble collagen are particularly preferable from the viewpoint of dispersion stability.

  These stabilizers can be added in an arbitrary ratio with respect to the entire oil component, but for stabilization of the emulsion, it is preferably 0.1 to 100 times the oil component, and 0 It is more preferably 5 times or more and 50 times or less.

  The aqueous composition according to the present invention contains, in addition to the components specifically described above for the aqueous composition, the compounds mentioned as components that can be added to the aqueous medium among the matters described regarding the aqueous dispersion. can do. In this case, the amount ratio of each component should just be able to be used by the quantity normally used with respect to the whole dispersion composition of this invention as a total amount of each of an aqueous dispersion and an aqueous composition.

The dispersion composition of the present invention is obtained by mixing the aqueous dispersion and the aqueous composition.
The average particle size of the emulsion particles contained in the dispersion composition is 200 nm or less from the viewpoint of maintaining transparency, and may be larger than the particle size of the emulsion particles in the aqueous dispersion. From the viewpoint of maintaining stability, the thickness is preferably 150 nm or less, more preferably 100 nm or less. The method for measuring the emulsion particles in the dispersion composition can be performed in the same manner as the method for measuring the emulsion particles in the aqueous dispersion.

The mixing of the aqueous dispersion and the aqueous composition is not particularly limited, and a small amount of the aqueous dispersion may be added to the large amount of the aqueous composition so that the aqueous dispersion becomes a part of the split acid composition. .
The amount of the aqueous dispersion added to the aqueous composition can be appropriately changed depending on the use of the dispersion composition, but is generally 0.01% by mass to 10% by mass with respect to the total mass of the dispersion composition. From the viewpoint of the coloring concentration of the aqueous dispersion, it is preferable to add the aqueous dispersion so that the blending amount is 0.05% by mass to 5% by mass, and further 0.1% by mass to 1% by mass. preferable.

The dispersion composition of the present invention may further contain a fragrance. Since the dispersion composition of the present invention contains ascorbic acid or a derivative thereof in the aqueous composition, it is possible to stabilize the fragrance of the fragrance and mask the scent from the carotenoid.
As the fragrance usable in the present invention, any of animal-based, plant-based, mineral-based natural fragrance and synthetic fragrance can be used. For example, rose extract, chamomile extract, green tea fragrance, lavender oil, geranium Oil, jasmine oil, bergamot oil, musk oil, ylang ylang oil, limonene, linalool, β-phenylethyl alcohol, 2,6-nonadienal, citral, cyclopentadecanone, eugenol, rose oxide, indole, phenylacetaldehyde dimethyl acetal, Examples include auranthiol. Among these fragrances, a rose extract, a chamomile extract, and a green tea fragrance are particularly preferable from the viewpoints of masking properties and aromas for carotenoid fragrance.
Although these fragrance | flavors may be mix | blended in the dispersion composition of this invention, it is preferable to mix | blend with an aqueous composition from a viewpoint of dispersion stability. In this case, in the aqueous composition, the blending amount is preferably 1% by mass to 50% by mass and preferably 5% by mass to 20% by mass with respect to the added mass of the aqueous dispersion. it can.

As described above, the dispersion composition of the present invention mixes a carotenoid-containing oil-soluble component and a phospholipid or derivative thereof with an aqueous phase to obtain an aqueous dispersion having emulsion particles, and the aqueous dispersion , Ascorbic acid or a derivative thereof and an aqueous composition containing 20% by mass or less of an oily component based on the total mass of the dispersion composition.
The carotenoid oil-soluble component, ascorbic acid or a derivative thereof are obtained through a two-step mixing process of mixing to obtain an aqueous dispersion and mixing the obtained aqueous dispersion and the aqueous composition. In particular, a dispersion composition excellent in storage stability in which emulsion particles having an average particle diameter of 200 nm or less are dispersed can be easily obtained.

The skin care cosmetic of the present invention comprises the dispersion composition of the present invention.
As described above, the dispersion composition of the present invention is a dispersion composition that particularly includes ascorbic acid or a derivative thereof and has excellent storage stability in which emulsion particles having an average particle diameter of 200 nm or less are dispersed. The skin care cosmetics to be included can similarly exhibit good storage stability.
There is no restriction | limiting in particular in the other component which can be used with this dispersion composition, Usually, the component which can be mix | blended as cosmetics can be used as it is, without a restriction | limiting in kind and compounding quantity.

  EXAMPLES Hereinafter, although an Example demonstrates this invention, this invention is not limited to this. In the following description, “parts” and “%}” are based on mass unless otherwise specified.

(1) Preparation of aqueous dispersions (i) -a and (i) -b Each component shown in Table 1 below was dissolved for 1 hour while heating at 70 ° C. to obtain an aqueous composition.
Moreover, each component of following Table 2 was melt | dissolved for 1 hour, heating at 70 degreeC, and the oil phase composition was obtained.

While maintaining the aqueous phase at 70 ° C., the mixture was stirred with a homogenizer (vacuum emulsifier PVQ-1D type manufactured by Mizuho Kogyo Co., Ltd.) (10000 rpm), and the oil phase composition was added thereto to obtain an emulsion. The obtained emulsion was subjected to high-pressure emulsification at 40 ° C. using an optimizer HJP-25005 (manufactured by Sugino Machine Co., Ltd.) at a pressure of 200 MPa.
Then, it filtered with the micro filter with an average hole diameter of 1 micrometer, and prepared astaxanthin containing water dispersion (i) -a.

  Astaxanthin-containing aqueous dispersion (i) -b was prepared in the same manner except that 90 g of pure water was added instead of 90 g of lecithin in the oil phase composition.

(2) Preparation of aqueous compositions (ii) -a to (ii) -g The components in Table 3 below were mixed and dissolved at room temperature to obtain aqueous compositions (ii) -a to (ii) -g.

(3) Preparation of dispersion composition [Example 1]
0.5 g of an aqueous dispersion (i) -a of Haematococcus alga extract is added to 999.5 g of the aqueous composition (ii) -a and mixed uniformly to obtain a red transparent dispersion (A). It was.
[Example 2]
1 g of an aqueous dispersion (i) -a of Haematococcus alga extract was added to 999 g of the aqueous composition (ii) -a and mixed uniformly to obtain a red transparent dispersion liquid (B).
[Example 3]
10 g of an aqueous dispersion (i) -a of Haematococcus alga extract was added to 990 g of the aqueous composition (ii) -a and mixed uniformly to obtain a red transparent dispersion liquid (C).
[Example 4]
20 g of an aqueous dispersion (i) -a of Haematococcus alga extract was added to 980 g of the aqueous composition (ii) -a, and mixed uniformly to obtain a red transparent dispersion (D).
[Example 5]
1 g of an aqueous dispersion (i) -a of Haematococcus alga extract was added to 999 g of the aqueous composition (ii) -b and mixed uniformly to obtain a red transparent dispersion liquid (E).

[Example 6]
Aqueous composition (ii) -b (980 g) was added with Haematococcus alga extract aqueous dispersion (i) -a (20 g) and mixed uniformly to obtain a red transparent dispersion (F).
[Example 7]
1 g of an aqueous dispersion (i) -a of Haematococcus alga extract was added to 999 g of the aqueous composition (ii) -c and mixed uniformly to obtain a red transparent dispersion liquid (G).
[Example 8]
1 g of an aqueous dispersion (i) -a of Haematococcus alga extract was added to 999 g of the aqueous composition (ii) -d and mixed uniformly to obtain a red transparent dispersion liquid (H).
[Example 9]
1 g of an aqueous dispersion (i) -a of Haematococcus alga extract was added to 999 g of the aqueous composition (ii) -e, and mixed uniformly to obtain a red transparent dispersion liquid (I).
[Example 10]

1 g of an aqueous dispersion (i) -a of Haematococcus alga extract was added to 999 g of the aqueous composition (ii) -f and mixed uniformly to obtain a red transparent dispersion (J).
[Comparative Example 1]
1 g of an aqueous dispersion (i) -a of Haematococcus alga extract was added to 999 g of the aqueous composition (ii) -g and mixed uniformly to obtain a red transparent dispersion liquid (K).
[Comparative Example 2]
1 g of an aqueous dispersion (i) -b of Hematococcus alga extract was added to 999 g of the aqueous composition (ii) -a, and mixed uniformly to obtain a red transparent dispersion (L).

(4) Measurement of physical property value An aqueous dispersion of Haematococcus alga extract is added to the aqueous composition obtained above and mixed uniformly, and a red transparent dispersion liquid corresponding to the dispersion composition of the present invention ( A) to (L) were obtained.
Each of the obtained dispersions (A) to (L) was filled into a light-shielding container, the lid was closed, and then placed in a thermostatic bath at 50 ° C., and the discoloration level of the dispersion over a period of 30 days (λmax: at 478 nm) Absorbance change), particle diameter, and visual property change (turbidity, precipitation) were confirmed as follows. The results are shown in Table 4.

Absorbance was determined by measuring an absorption spectrum at 478 nm using a UV-VIVE spectrum photometer UV-2550 (manufactured by Shimadzu Corporation). The evaluation was performed based on the following evaluation criteria, using the absorbance remaining rate as the discoloration level of the dispersion from the absorbance at 50 ° C. for 30 days with respect to the absorbance immediately after mixing the aqueous composition and the aqueous dispersion.
○: Absorbance remaining ratio of 85% or more Δ: Absorbance remaining ratio of 70% or more

The particle size of the emulsion in the dispersion was measured using a dynamic light scattering particle size dispersion measuring device LB-550 (manufactured by Horiba, Ltd.). The evaluation was performed based on the following evaluation criteria by determining the change in particle diameter immediately after mixing the aqueous composition and the aqueous dispersion and after 30 days at 50 ° C.
○: 20 nm or less Δ: 70 nm or less ×: Over 70 nm

The visual property change was evaluated according to the following evaluation criteria by visually observing the properties of the aqueous composition after 30 days at 50 ° C.
○: Appearance change cannot be recognized immediately after mixing.
Δ: Some turbidity is felt in the liquid.
×: Vigorous turbidity occurs. The liquid is separated. Precipitation is occurring.
(Please add it.)

From the above results, the dispersions according to the examples of the present invention had a small average particle size immediately after emulsification, and the particle size hardly changed even after storage. In visual observation of the emulsion after forced storage, the color change and property change were small, and no turbidity or precipitation was observed.
Thus, according to the present invention, it is possible to supply an aqueous composition that is small in particle diameter, color, and property change with time and excellent in stability.

Claims (9)

(A) Emulsion particles having an average particle size of 200 nm or less containing astaxanthin, polyglycerin fatty acid ester, and phospholipid or a derivative thereof;
(B) at least one ascorbic acid derivative selected from magnesium ascorbyl phosphate and sodium ascorbyl phosphate; and
(C) Oil component of 20% by mass or less based on the mass of the entire dispersion composition
A dispersion composition comprising: The dispersion composition according to claim 1, wherein the phospholipid or derivative thereof is lecithin. The dispersion composition according to claim 1 or 2 , further comprising tocopherol. The dispersion composition according to any one of claims 1 to 3, wherein the astaxanthin is derived from an extract of Haematococcus alga. The dispersion composition according to any one of claims 1 to 4, further comprising glycerin. A skin care cosmetic comprising the dispersion composition according to any one of claims 1 to 5 . It is a manufacturing method of the dispersion composition of any one of Claims 1-5, Comprising :
Mixing an aqueous phase with a carotenoid-containing oil-soluble component containing astaxanthin , polyglycerin fatty acid ester and phospholipid or a derivative thereof, to obtain an aqueous dispersion having emulsion particles,
The aqueous dispersion, an aqueous composition comprising at least one ascorbic acid derivative selected from sodium ascorbyl phosphate and magnesium ascorbyl phosphate, and an oily component of 20% by mass or less based on the total mass of the dispersion composition. Mixing to obtain a dispersion composition having emulsion particles with an average particle size of 200 nm or less,
The manufacturing method of the dispersion composition containing this. The manufacturing method of the dispersion composition of Claim 7 whose content of phospholipid or its derivative (s) is 0.001 mass% or more and 20 mass% or less with respect to the mass of the said whole water dispersion.   The dispersion composition obtained by the manufacturing method of Claim 7 or Claim 8.