CN113332205B - Composition and cosmetic composition with effects of whitening and brightening skin color - Google Patents

Abstract

The invention discloses a composition with whitening and skin color brightening effects and a cosmetic composition, and relates to the technical field of cosmetics, wherein the composition with the whitening and skin color brightening effects comprises the following components in parts by weight: citrus peel extract: 0.1-5 parts; extract of Tianzhu fruit: 0.1-10 parts; nicotinamide: 0.1-10 parts; d-panthenol: 0.1-5 parts; soluble proteoglycan: 0.1-3 parts. According to the invention, the citrus peel extract, the triquetrum extract, the nicotinamide, the D-panthenol and the soluble proteoglycan in a specific ratio are used in a matched manner, wherein the D-panthenol and the soluble proteoglycan can play a role in self moisture retention and water supplement, promote the whitening effects of the citrus peel extract, the triquetrum extract and the nicotinamide, further enhance the barrier effect of the cuticle and inhibit the melanin effect, improve the water content and intercellular compactness of the cuticle, and have the effects of whitening, homogenizing and brightening the skin color.

Description

Composition and cosmetic composition with effects of whitening and brightening skin color

Technical Field

The invention relates to the technical field of cosmetics, and particularly relates to a composition with whitening and skin color brightening effects and a cosmetic composition.

Background

The pursuit of oriental women for whitening is always uninterrupted, and the 'white shading ugly', 'skin like snow' and 'coagulation like fat' are the skin states of people, but the skin of people becomes dull, red, yellow, melanin aggregation, loss of luster, uneven skin color and the like under the influence of various factors such as living environment, sun irradiation, irregular life, natural aging process and the like, and the demand of people for whitening products is increased day by day.

Melanin belongs to amino acid derivatives, which are widely present in the human body; the formation of melanin is related to skin color, the more melanin, the darker the skin color. Melanocytes are destroyed by external influences and increase in number, forming melanin. Factors affecting melanin formation are: ultraviolet irradiation causes melanocytes to proliferate in large quantities to form pigmentation; also, inflammation, metabolic disorder, poor lifestyle, poor diet, mental factors, endocrine factors, etc. may cause an increase in melanin.

Traditional whitening agents such as hydroquinone, lead, mercury-containing compounds, hormones, etc., which cause irreversible damage to the skin, have become banned substances; VC, arbutin, kojic acid and the like have poor stability and large irritation; these potent tyrosinase inhibitors, which aim at reducing melanin, may destroy or even kill melanocytes, resulting in a melanin imbalance. Melanin has a protective effect on human skin, which is reduced if excessive intervention in melanin formation occurs.

Recently, many companies have developed some whitening compositions, and more indeed some products with simply superimposed effects, which are difficult to achieve. The development of safe, efficient, healthy, comprehensive and comprehensive whitening products will become the main development direction of future whitening products.

Disclosure of Invention

The invention aims to solve the technical problem of providing a composition with the effects of whitening and brightening skin color, which has the effects of enhancing the barrier effect of stratum corneum, inhibiting melanin, improving the water content and intercellular compactness of stratum corneum and whitening, homogenizing and brightening the skin color by adopting the cooperation of a citrus peel extract, a triquetum extract, nicotinamide, D-panthenol and soluble proteoglycan in a specific proportion.

In order to solve the technical problems, the invention aims to realize the following technical scheme: the composition with the effects of whitening and brightening the skin color is prepared from the following components in parts by weight:

citrus peel extract: 0.1-5 parts;

extract of Tianzhu fruit: 0.1-10 parts;

nicotinamide: 0.1-10 parts;

d-panthenol: 0.1-5 parts;

soluble proteoglycan: 0.1-3 parts.

Further, the composition with the effects of whitening and brightening the skin color comprises the following components in parts by weight:

citrus peel extract: 0.3-4 parts;

extract of triquetrum: 0.5-6 parts;

nicotinamide: 0.5-6 parts;

d-panthenol: 0.3-4 parts;

soluble proteoglycan: 0.3-2 parts.

Further, the composition with the effects of whitening and brightening the skin color comprises the following components in parts by weight:

citrus peel extract: 1 part;

extract of Tianzhu fruit: 2 parts of a mixture;

nicotinamide: 2 parts of (1);

d-panthenol: 1 part;

soluble proteoglycan: 0.5 part.

Further, the nicotinamide is a cosmetic raw material with the nicotinic acid content of less than 100 PPM.

In addition, the technical problem to be solved by the present invention is to provide a cosmetic composition, comprising the above composition with skin whitening and skin color brightening effects, wherein the composition with skin whitening and skin color brightening effects accounts for 0.5-33% of the total weight of the cosmetic composition.

Further, the cosmetic composition also comprises cosmetic auxiliary materials: 67-99.5 percent.

Further, the cosmetic auxiliary materials are selected from one or more of emulsifier, emollient, solubilizer, thickener, skin conditioner, humectant, pH regulator, preservative, chelating agent, essence and deionized water.

Further, the humectant is selected from one or more of glycerol, butanediol, propylene glycol, dipropylene glycol, 1, 3-propanediol, glycerol acrylate/acrylic acid copolymer, glyceryl polyether-26, hexanediol, 1, 2-pentanediol, caprylyl glycol, ethylhexyl glycerin, polyethylene glycol-32, urea, allantoin, PEG/PPG-17/6 copolymer, PPG-28-buthanol polyether-35, bis-PEG-18 methyl ether dimethylsilane and sorbitol.

Further, the thickening agent is selected from one or more of acryloyl dimethyl ammonium taurate/VP copolymer, sodium polyacrylate, acrylic acid (ester) copolymer sodium, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, polyacrylate-13, acryloyl dimethyl ammonium taurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, xanthan gum and carbomer.

Further, the preservative is selected from one or more of parabens, phenoxyethanol, chlorphenesin, caprylyl hydroximic acid, glyceryl caprylate, benzoic acid and salts thereof, dehydroacetic acid and salts thereof, 1, 2-pentanediol, ethylhexyl glycerol and caprylyl glycol;

the pH regulator is one or more of citric acid, sodium citrate, sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine, acetic acid and lactic acid.

As a preferred technical scheme, the cosmetic auxiliary material comprises: 1-10% of glycerol, 1-10% of butanediol, 1-10% of dipropylene glycol, 0.05-0.5% of xanthan gum, 0.05-0.5% of carbomer, 0.05-0.5% of arginine, 0.3-0.8% of preservative and the balance of water.

As a further preferred technical solution, the cosmetic auxiliary material includes: 3-8% of glycerin, 3-8% of butanediol, 3-8% of dipropylene glycol, 0.2-0.3% of xanthan gum, 0.1-0.2% of carbomer, 0.1-0.2% of arginine, 0.4-0.6% of preservative and the balance of water.

As a more preferable technical solution, the cosmetic auxiliary material includes: 5% of glycerin, 5% of butanediol, 5% of dipropylene glycol, 0.2% of xanthan gum, 0.1% of carbomer, 0.1% of arginine, 0.5% of preservative and the balance of water.

In the technical solution of the present invention, the properties of the cosmetic composition used are as follows:

the citrus peel extract: the extract is extracted from Mandarin orange by supercritical extraction technology, and is rich in flavonoids. The stratum corneum functions as a barrier to skin defense, and protects the skin from damage, but if the intercellular junctions of the stratum corneum are not sufficiently tight, the barrier efficacy of the skin defense is also greatly reduced. In the composition, the citrus peel extract can reduce the gaps between adjacent cells, improve the cuticle into a smoother and smoother state, is beneficial to the injection of light and the reflection of light to the skin to have natural brightness, and improves the transparency of the skin.

Extract of Tianzhu fruit: the product name of dragon fruit is extracted by supercritical technology, and contains vegetable protein, anthocyanin, abundant vitamins and water-soluble dietary fiber. In the composition, the gaultheria zizanoides achieves the effect of whitening skin by inhibiting the movement of melanin in melanocytes and reducing the migration of melanin.

Nicotinamide: also known as vitamin B3, and is chemically named 3-pyridinecarboxamide. Nicotinamide has anti-inflammatory, skin cutin barrier improving, skin moistening, and skin pigmentation reducing effects. In the compositions of the present invention, niacinamide prevents pigment transfer to the skin surface, can reduce skin pigmentation, and contributes to a safe, efficient, uniform skin color.

As a preferable technical scheme, the nicotinamide selects cosmetic raw materials with the nicotinic acid content of less than 100PPM, so that the nicotinamide can prevent pigments from transferring to the surface of the skin, reduce the pigmentation of the skin and simultaneously cause no skin discomfort or sensitivity problems.

D-panthenol: also called provitamin B5, is a deeply penetrating moisturizer, improves and increases skin moisture, and makes skin softer and more elastic; stimulating the growth and development of the squamous epithelial cells, helping the repair and healing of small wounds and playing a role in diminishing inflammation.

Preferably, the D-panthenol used in the present invention is a cosmetic grade material with a content of more than 98%.

Soluble proteoglycan: the proteoglycan is one kind of proteoglycan extracted from salmon nasal cartilage tissue, has one or several covalent bonds capable of being connected to mucopolysaccharide (GAG) matter, such as chondroitin sulfate and dermatan sulfate, as one kind of main extracellular tissue components, and is beneficial to human body tissue including skin and cartilage tissue, can increase the amount of hyaluronic acid in fibroblast and has long-acting moisture maintaining effect.

The inventor finds that in the composition, the D-panthenol and the soluble proteoglycan can play a role in self moisturizing and hydrating, and can promote the whitening effects of the citrus peel extract, the triquetum extract and the nicotinamide, and the specific action mechanism is as follows: promoting the citrus peel extract to enhance the barrier function of the stratum corneum, the water content of the stratum corneum and the intercellular compactness; the effect of inhibiting melanin of the triquetrum extract is improved, the effect of improving the skin cutin barrier and preventing pigment from transferring to the skin surface by the nicotinamide is improved, so that the composition has the effects of whitening, homogenizing and brightening the skin color.

Compared with the prior art, the invention has the following beneficial effects:

the invention adopts the citrus peel extract, the triquetrum extract, the nicotinamide, the D-panthenol and the soluble proteoglycan in a specific proportion to be matched for use, can overcome the defects of the traditional whitening agent, and realizes the comprehensive whitening by adopting the safe, mild, effective and synergistic effects. Wherein, the D-panthenol and the soluble proteoglycan can play a role in self moisture retention and water supplement and can also promote the barrier effect of the citrus peel extract on the horny layer, the water content of the horny layer and the intercellular compactness; the skin care product has the beneficial effects that the effect of the triquetrum extract on inhibiting melanin is improved, the effect of the nicotinamide on improving the skin cutin barrier and preventing pigments from transferring to the skin surface is improved, the components have the synergistic effect, the melanogenesis can be inhibited, the skin color can be brightened, the skin resistance and the skin luster can be enhanced, and the effects of whitening, homogenizing and brightening the skin color are realized, so that the purposes of safe skin care and effective whitening are realized, and the skin care product can be used for daily care of various skin types of people.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It will be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.

It is also to be understood that the terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in the specification of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

It should be further understood that the term "and/or" as used in this specification and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.

In the inventive examples and comparative examples, the following percentages (%) are by weight unless otherwise specified. In the examples of the invention and the comparative examples, the cosmetic composition was essence.

Examples 1 to 6

The contents (%) of the respective components of the cosmetic compositions comprising the composition having the whitening and skin color-lightening effects provided in examples 1 to 6 are shown in table 1.

Table 1:

the preparation method of the cosmetic compositions of examples 1 to 6 includes the steps of:

uniformly mixing glycerol, butanediol, dipropylene glycol, xanthan gum and carbomer, adding into deionized water, stirring, heating to 85 ℃, keeping the temperature, stirring for 20 minutes, cooling to 60 ℃, adding arginine, cooling to 45 ℃, adding a preservative, an orange peel extract, a triquetrum extract, nicotinamide, D-panthenol and soluble proteoglycan, stirring, uniformly mixing, cooling to room temperature, and discharging after the detection is qualified to obtain the essence.

Comparative examples 1 to 5

The contents (%) of the respective components of the cosmetic compositions comprising the composition having whitening and skin color-lightening effects provided in comparative examples 1 to 5 are shown in Table 2.

Table 2:

comparative examples 6 to 11

The contents (%) of the respective components of the cosmetic compositions comprising the composition having whitening and skin color-lightening effects provided in comparative examples 6 to 11 are shown in Table 3.

Table 3:

the cosmetic compositions of comparative examples 1 to 11 were prepared in the same manner as the cosmetic compositions of examples 1 to 6.

In the examples and the comparative examples, the preservative is selected from one or more of parabens, phenoxyethanol, chlorphenesin, caprylic hydroxamic acid, glyceryl caprylate, benzoic acid and salts thereof, dehydroacetic acid and salts thereof, 1, 2-pentanediol, ethylhexyl glycerol, and caprylyl glycol.

Through tests, in the examples and the comparative examples, the humectant can also be selected from one or a combination of any more of propylene glycol, 1, 3-propylene glycol, glycerin acrylate/acrylic acid copolymer, glyceryl polyether-26, hexylene glycol, 1, 2-pentanediol, caprylyl glycol, ethylhexyl glycerin, polyethylene glycol-32, urea, allantoin, PEG/PPG-17/6 copolymer, PPG-28-buthanol polyether-35, bis-PEG-18 methyl ether dimethylsilane and sorbitol.

The thickening agent can also be selected from one or the combination of any more of acryloyl dimethyl ammonium taurate/VP copolymer, sodium polyacrylate, acrylic acid (ester) copolymer sodium, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, polyacrylate-13, acryloyl dimethyl ammonium taurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer and hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer.

The pH regulator can also be one or more of citric acid, sodium citrate, sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, acetic acid, and lactic acid.

Effect testing

The test method comprises the following steps:

test objects: 170 healthy 25-50 year old women, randomized into 17 groups of 10 people each.

Test area: face (blank sample for left face, control or example sample for right face).

Use of: applied once a day, in the morning and evening, and is used for 4 weeks.

Testing an instrument: CK skin tester (germany), VISIA full face analyzer (germany).

The effect indexes are as follows: the transdermal water loss rate, the facial brightness L value and the white degree ITA degree, and the lower the transdermal water loss rate is, the better the skin barrier is; the larger the value of facial brightness L, the better the skin brightening effect of the product is; the higher the ITA degree is, the better the product is.

Measuring the skin percutaneous water loss rate by using a CK skin tester after 4 weeks, and measuring a delta L value and a fair degree delta ITA degree of the change of the facial brightness before and after use by using VISA; where Δ L × and Δ ITA ° are the average values of all test subjects.

The test results are shown in table 4.

Table 4: test results of examples 1 to 6 and comparative examples 1 to 11

Sample set	Rate of water loss through skin	△L*	△ITA°
				Comparative example 1	2.58	3.25	3.65
Comparative example 2	2.63	3.02	3.12
				Comparative example 3	1.95	3.86	4.01
Comparative example 4	2.42	1.30	1.12
				Comparative example5	1.53	1.67	1.20
Comparative example 6	1.90	4.02	4.70
				Comparative example 7	1.98	4.13	4.82
Comparative example 8	1.75	4.26	4.90
				Comparative example 9	2.16	3.55	4.30
Comparative example 10	2.23	3.67	4.51
				Comparative example 11	1.65	3.85	4.62
Example 1	0.80	4.91	5.48
				Example 2	0.55	5.36	5.32
Example 3	0.72	5.09	5.65
				Example 4	0.70	5.06	5.54
Example 5	0.56	5.13	5.78
				Example 6	0.35	5.85	6.10

According to the test data in table 4, comparing the test results of examples 1-6 of the present invention with those of comparative examples 1-5, the cosmetic compositions of examples 1-6 have significantly improved effects in terms of repairing the barrier of the horny layer, lightening the skin color, whitening the skin, etc. when the total weight percentage content of the citrus peel extract, the gaultheria bidens extract, nicotinamide, D-panthenol and soluble proteoglycan of examples 1-6 is the same as the content of the individual components of comparative examples 1-5, i.e., the 5 compositions of the present invention have better synergistic effects than the single components of the same content.

Comparing the test results of examples 1-6 with those of comparative examples 6-10, the effect was far less than that achieved by the synergistic effect of 5 compositions in the absence of one or both of the components citrus peel extract, the extract of gaultheria zizanoides, niacinamide, D-panthenol and soluble proteoglycan.

Comparing the test results of examples 1-6 with those of comparative example 11, the composition of comparative example 11 was far less effective in terms of stratum corneum barrier repair, lightening skin color, whitening skin, etc. than the compositions of examples 1-6 by increasing the component contents of citrus peel extract, trivia quinquefolia extract, niacinamide in the absence of D-panthenol and soluble proteoglycan.

The results show that the composition has better synergistic effect in aspects of stratum corneum barrier repair, skin color brightening, skin whitening and the like. The D-panthenol and the soluble proteoglycan can play a role in self moisture retention and water supplement, and can promote the effects of enhancing the barrier effect of the cuticle and inhibiting melanin of the citrus pericarp extract, the triquetrum extract and the nicotinamide, improve the water content and intercellular compactness of the cuticle, and improve the effects of whitening, homogenizing and brightening the skin color.

In order to further verify the optimal mixture ratio of the composition with the effects of whitening and brightening the skin color, the invention also provides examples 7-13.

Examples 7 to 13

The contents (%) of the respective components of the cosmetic compositions comprising the composition having whitening and skin color-lightening effects provided in comparative examples 7 to 13 are shown in Table 5.

Table 5:

the cosmetic compositions of examples 7 to 13 were prepared in the same manner as the cosmetic compositions of examples 1 to 6.

Effect testing

Test objects: 70 healthy women, 25-50 years old, were randomized into 7 groups of 10 people each.

Test area: face (blank sample for left face and example sample for right face).

Use of: applied once a day, in the morning and evening, and is used for 4 weeks.

Testing an instrument: CK skin tester (germany), VISIA full face analyzer (germany).

The effect indexes are as follows: the transdermal water loss rate, the facial brightness L value and the white degree ITA degree, wherein the lower the transdermal water loss rate is, the better the skin barrier is; the larger the value of facial brightness L, the better the skin brightening effect of the product is; the higher the ITA degree, the better the product is able to whiten skin.

Measuring the skin percutaneous water loss rate by using a CK skin tester after 4 weeks, and measuring a delta L value and a fair degree delta ITA degree of the change of the facial brightness before and after use by using VISA; where Δ L × and Δ ITA ° are the average values of all test subjects.

The test results are shown in table 6.

Table 6: test results of examples 7 to 13

Sample set	Rate of percutaneous water loss	△L*	△ITA°
				Example 7	1.40	4.30	4.93
Example 8	1.35	4.33	4.96
				Example 9	1.16	4.32	5.15
Example 10	0.95	4.96	5.56
				Example 11	0.38	5.78	5.97
Example 12	0.36	5.75	5.83
				Example 13	0.40	5.82	5.79

The test results of comparative example 6 and examples 7 to 13 show that the cosmetic compositions of examples 6 to 13 have significant effects in terms of stratum corneum barrier repair, skin lightening, skin whitening, etc., but the higher the content of each component is, the better the effect is, and the compositions of comparative example 6 and examples 10 to 13 have an enhanced effect of increasing the content of the component at a low content, but the effect of increasing the content of the component at a certain ratio is not significant. Therefore, the technical means of the present invention using citrus peel extract, triquetum extract, niacinamide, D-panthenol and soluble proteoglycan are not simple additions or substitutions between components.

Appearance stability test

The compositions of examples 6 to 13 were allowed to stand at room temperature, 45 ℃ and under sunlight for 1 month, and the change in appearance of each composition was observed, and the test results are shown in Table 7.

Table 7: appearance stability test results for examples 6-13:

sample set	Normal temperature (1 month)	45 deg.C (1 month)	Illumination (1 month)
				Example 6	Is normal	Is normal	Is normal
Example 7	Is normal	Is normal	Is normal
				Example 8	Is normal	Is normal	Is normal
Example 9	Is normal	Is normal	Is normal
				Example 10	Is normal	Is normal	Is normal
Example 11	Is normal and normal	Slight yellowing	Yellowing of
				Example 12	Is normal	Deep yellow	Deep yellow
Example 13	Slight yellowing	Become dark yellow	Deep yellow

As can be seen from the test results in Table 7, in comparison with examples 6-13 of the present invention, the stability is increased with the content of the components, and the discoloration is severe, i.e., the synergistic effect between the compositions has certain requirements on the content of each component, and the optimal component ratio can ensure the stability of the product while exerting better effect.

It is particularly noted that the cosmetic composition of the invention can be prepared into cosmetics of other formulations, such as skin lotion, skin emulsion, skin cream, skin gel and the like, and the cosmetics of other formulations have the same effect as the effect proved by the embodiment within the range of the mixture ratio disclosed by the invention.

While the invention has been described with reference to specific embodiments, the invention is not limited thereto, and various equivalent modifications and substitutions can be easily made by those skilled in the art within the technical scope of the invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (9)

1. The composition with the effects of whitening and brightening the skin color is characterized by comprising the following components in parts by weight:

citrus peel extract: 0.3-2 parts;

extract of Tianzhu fruit: 0.5-2 parts;

nicotinamide: 0.5-2 parts;

d-panthenol: 0.3-1 part;

soluble proteoglycan: 0.3-1 part.

2. The composition with the effects of whitening and brightening the skin color according to claim 1 is characterized by comprising the following components in parts by weight:

citrus peel extract: 1 part;

extract of Tianzhu fruit: 2 parts of (1);

nicotinamide: 2 parts of (1);

d-panthenol: 1 part;

soluble proteoglycan: 0.5 part.

3. The composition with skin whitening and brightening effects according to any one of claims 1-2, characterized in that the niacinamide is a cosmetic raw material with a niacin content of less than 100 ppm.

4. A cosmetic composition comprising the composition having skin whitening and color brightening effects of any one of claims 1 to 3, wherein the composition having skin whitening and color brightening effects accounts for 0.5 to 33% of the total weight of the cosmetic composition.

5. The cosmetic composition of claim 4, further comprising cosmetic adjuvants: 67-99.5 percent.

6. The cosmetic composition of claim 5, wherein the cosmetic adjuvant is selected from the group consisting of emulsifiers, emollients, solubilizers, thickeners, skin conditioners, humectants, pH adjusters, preservatives, chelating agents, fragrances, deionized water, in combination or combinations thereof.

7. The cosmetic composition of claim 6, wherein the humectant is selected from the group consisting of glycerin, butylene glycol, propylene glycol, dipropylene glycol, 1, 3-propanediol, glyceryl acrylate/acrylic acid copolymer, glyceryl polyether-26, hexylene glycol, 1, 2-pentanediol, caprylyl glycol, ethylhexyl glycerin, polyethylene glycol-32, urea, allantoin, PEG/PPG-17/6 copolymer, PPG-28-buthylenether-35, bis-PEG-18 methyl ether dimethylsilane, and sorbitol.

8. The cosmetic composition of claim 6, wherein the thickener is selected from the group consisting of one or more of ammonium acryloyl dimethyltaurate/VP copolymer, sodium polyacrylate, sodium acrylate copolymer, hydroxyethyl acrylate/sodium acryloyl dimethyltaurate copolymer, polyacrylate-13, ammonium acryloyl dimethyltaurate/beheneth-25 methacrylate crosspolymer, xanthan gum, and carbomer.

9. The cosmetic composition of claim 6, wherein the preservative is selected from the group consisting of parabens, phenoxyethanol, chlorphenesin, caprylhydroxamic acid, glyceryl caprylate, benzoic acid and salts thereof, dehydroacetic acid and salts thereof, 1, 2-pentanediol, ethylhexylglycerin, caprylyl glycol;

the pH regulator is one or more of citric acid, sodium citrate, sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine, acetic acid and lactic acid.