CN108578300B - skin care gel with synergistic whitening effect and preparation method thereof - Google Patents
skin care gel with synergistic whitening effect and preparation method thereof Download PDFInfo
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Abstract
The invention discloses skin-care gels with a synergistic whitening effect, which comprise, by mass, 1.0-3.0% of nicotinamide, 0.5-1.5% of citrus peel extract, 0.1-0.5% of arbutin, 1.0-4.0% of whitening compound 1, 0.5-5.0% of whitening compound 2 and 86.0-96.9% of cosmetic auxiliary material matrix, wherein the skin can be prevented from obtaining negative feedback signals such as melanin reduction and melanin requirement due to sudden enhancement of signals of certain whitening nodes by adopting the components.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to skin-care gels with a synergistic whitening effect and a preparation method thereof.
Background
East asian women were beautiful with white from ancient times, and many methods such as milk bath and the like were used for whitening. Even many toxic substances, such as the early lead and mercury facings, were used until the last century. Many whitening agents have been developed and selected since the recent years.
Currently, , the most effective skin lightening active, is hydroquinone, however, hydroquinone has a small molecular weight, destroys melanocytes, and may induce inflammation, and therefore, hydroquinone is subject to strict regulations in most countries throughout the world and is banned from use as a cosmetic ingredient.
Rhododendrol was once the whitening active mastered by the japanese famous cosmetics company however, there was a later outbreak of over-whitening problem the company's patent was regrouped with the customer for this problem.
Azelaic acid is a naturally occurring medium chain length fatty acid which is an important skin lightening agent with tyrosinase inhibiting effect, however, there are technical and formulation problems in application firstly azelaic acid must be effective at high concentrations where it does not dissolve making formulated cosmetic quality poor, especially very thick systems difficult to wipe.
L-ascorbic acid and its derivatives and licorice extract are easy to discolor, and its stability is not a little problem, and special attention is required for use.
Moreover, in order to make a short-term profit, some illegal merchants add glucocorticoid to cosmetics such as facial masks, which can produce whitening and firming effects in a short term, but have very serious consequences on human skin after long-term use.
The skin color is controlled by various factors, but mainly depends on the content and distribution of melanin, melanin is produced by melanocyte, which is important constituent cells of skin and is in the form of dendriform, melanin formed in cells is transported into stratum corneum cells through the dendriform, the dendriform forms epidermal units with keratinocytes in a ratio of 1: 36, exists in the epidermal basal layer, and the melanocyte determines the skin color by synthesizing melanin and can absorb ultraviolet rays so as to prevent the body from being damaged by the ultraviolet rays.
Recently, many companies developed whitening compositions, and more than products with simple additive effects are difficult to achieve the expected effects, so how to develop a high-efficiency, safe and stable whitening scheme with synergy becomes difficult points in the cosmetic industry.
Disclosure of Invention
In order to overcome the technical defects, of the present invention is to provide skin care gels with synergistic whitening effects, which not only can inhibit tyrosinase activity and melanin transfer to achieve the purpose of whitening, but also can act synergistically in other aspects to achieve the outstanding whitening effect and simultaneously achieve balanced cooperation without negative feedback.
In order to solve the problems, the invention is realized according to the following technical scheme:
skin care gel with synergistic whitening effect, which comprises the following components in percentage by mass:
wherein the whitening complex 1 comprises water, butylene glycol, arbutin, citric acid, sodium sulfite, acetyl tyrosine, strawberry saxifrage extract, peony root extract, aminopropanol ascorbic acid phosphate, scutellaria root extract, glutathione, hydrolyzed cherry plum;
the whitening compound 2 comprises glycerin, butylene glycol, extract of bearberry (Arctostaphylylos UVA URSI) leaf, extract of Psidium guajava (MITARCARPUS SCABER), sodium metabisulfite, and biotin.
Nicotinamide has outstanding effects in inhibiting melanosome transfer and accelerating damaged DNA repair. When the content of the nicotinamide in the skin care gel is lower than 1%, the overall whitening effect is greatly weakened through tests; when the nicotinamide content is more than 3%, the cytotoxicity is too high through in vitro cell tests. Therefore, the content of nicotinamide is 1-3%.
The citrus peel extract in the skin care gel disclosed by the invention has the effect of coordinating with other components to enable the skin to be smoother and brighter, and the total flavone content and the types of the citrus peel extract are standards of the quality of the citrus peel extract, the citrus peel extract in the skin care gel disclosed by the invention adopts a carbon dioxide supercritical extraction technology, the total flavone content of the citrus peel extract extracted by the technology can be more than 2.5%, is obviously higher than that extracted by other modes, and has the advantages of environmental friendliness and energy conservation.
Arbutin has the ability to inhibit the activity of tyrosinase, a key enzyme in the process of melanin production, and also has the effect of absorbing ultraviolet rays. Because arbutin has similarity with tyrosine in structure, the arbutin can compete with tyrosine to bind tyrosinase in the process of synthesizing melanin by tyrosine, thereby reducing the effect of tyrosinase on synthesizing melanin. In the test of the skin care gel of the present invention, when the content of arbutin is less than 0.1%, the whitening effect is very small; when the arbutin content is more than 0.5 percent, the skin care gel of the invention is easy to turn red in the storage process. Therefore, the content of arbutin is 0.1-0.5%.
In the whitening compound 1, arbutin and scutellaria root extracts can absorb ultraviolet rays; radix Scutellariae extract and radix moutan extract can inhibit inflammatory factor activity; arbutin can inhibit tyrosinase activity; the extract of herba Saxifragae, radix Scutellariae extract, and ascorbic acid phosphate aminopropanol can inhibit natural oxidative polymerization of melanin and reduce melanin formation; the extract of herba Saxifragae can repair DNA damage caused by ultraviolet; glutathione can promote the synthesis of pheomelanin but not eumelanin; acetyl tyrosine is able to compete with tyrosine for tyrosinase; the aminopropanol ascorbic acid phosphate and citric acid can promote cell proliferation and keratinocyte renewal; hydrolyzed cherry plum can inhibit melanin from being engulfed by keratinocyte. Through research and experimental analysis on the mechanism, in the skin care gel, when the dosage of the whitening compound 1 is less than 1%, the whitening effect of the skin care gel is not obvious; when the whitening complex 1 is used in an amount higher than 4%, the heat-resistant and light-resistant stability of the skin care gel of the present invention is deteriorated. Thus, the selective amount of whitening complex 1 is 1-4%.
In the whitening compound 2, the extract of the malpighia glabra contains hydrogenated quinine derivatives, and is compounded with the extract of the bearberry leaves, so that the malpighia glabra has a powerful inhibitory effect on the neuraminidase. In the skin care gel, when the dosage of the whitening compound 2 is less than 0.5%, the skin care gel has a non-obvious whitening effect; when the whitening complex 2 is used in an amount of more than 5%, the heat-resistant and light-resistant stability of the skin care gel of the present invention is deteriorated. Therefore, the selective amount of whitening complex 2 is 0.5-5%.
, the composition comprises the following components in percentage by mass:
, the whitening compound 1 comprises the following components in percentage by mass:
46.3-50.0% of water, 40.0-50.0% of butanediol, 0.3-0.8% of arbutin, 0.3-0.6% of citric acid, 0.4-0.6% of sodium sulfite, 0.1-0.3% of acetyltyrosine, 0.01-0.3% of strawberry saxifrage extract, 0.01-0.2% of peony root extract, 0.001-0.1% of aminopropanol ascorbic acid phosphate ester, 0.01-0.1% of scutellaria root extract, 0.001-0.1% of glutathione and 0.01-0.6% of hydrolyzed cherry plum.
, the whitening compound 2 comprises the following components in percentage by mass:
45.0-65.0% of glycerin, 10.0-30.0% of butanediol, 5.0-15.0% of bearberry (Arctostaphylosuva URSI) leaf extract, 5.0-10.0% of crabapple (Mitracarpus siber) extract, 0.01-0.1% of sodium metabisulfite and 0.001-0.01% of biotin.
, the cosmetic auxiliary material matrix comprises the following components in percentage by mass:
1.0-30.0% of humectant, 0.01-2.0% of chelating agent, 0.05-5.0% of thickening agent, 0.1-40.0% of emollient, 0.01-37.0% of skin conditioning agent, 0.01-1.0% of solubilizer, 0.01-1.0% of essence, 0.01-1.0% of preservative and 20.0-98.0% of water.
, the humectant is or more of glycerol, propylene glycol, 1, 3-propylene glycol, butylene glycol, hexylene glycol, 1, 2-pentanediol, caprylyl glycol, allantoin, sorbitol, and betaine;
the chelating agent is or more of disodium EDTA, tetrasodium EDTA, citric acid and sodium citrate;
the thickening agent is or more of acryloyl dimethyl taurate/VP copolymer, sodium polyacrylate, acrylic acid (ester) copolymer sodium, hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer, polyacrylate-13, acryloyl dimethyl taurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer and hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer;
the skin moistening machine is or more of mineral oil, isohexadecane, shea butter, olive oil, polydimethylsiloxane, caprylic/capric triglyceride, tri (ethyl hexanoate) glyceride, squalane, ethylhexyl palmitate, hydrogenated polydecene, cyclopenta dimethyl siloxane, and cyclohexasiloxane;
the skin conditioner is α -mannan, sodium hyaluronate, sodium PCA, betaine, polyquaternium-51, fructan, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, Chondrus CRISPUS (Chondrus CRISPUS) extract, chitosan, β -dextran, and creatine or more.
, the nicotinamide is cosmetic material with nicotinic acid content less than 100 PPM.
, the citrus peel extract adopts the carbon dioxide supercritical extraction technology, and the total flavone content of the citrus peel extract is more than 2.5%.
, the arbutin is a cosmetic grade material with a content of more than 98%.
In order to overcome the technical defects, the second object of the present invention is to provide a preparation method of skin care gels with synergistic whitening effect, wherein the preparation method is simple and fast.
In order to solve the problems, the invention is realized according to the following technical scheme:
A preparation method of skin care gel with synergistic whitening effect comprises the following steps:
s1, batching: preparing the following raw material components in percentage by mass: 1.0-3.0% of nicotinamide, 0.5-1.5% of citrus peel extract, 0.1-0.5% of arbutin, 1.0-4.0% of whitening compound 1, 0.5-5.0% of whitening compound 2 and 86.0-96.9% of cosmetic auxiliary material matrix;
wherein the whitening complex 1 comprises water, butylene glycol, arbutin, citric acid, sodium sulfite, acetyl tyrosine, strawberry saxifrage extract, peony root extract, aminopropanol ascorbic acid phosphate, scutellaria root extract, glutathione, hydrolyzed cherry plum;
the whitening compound 2 comprises glycerin, butylene glycol, extract of bearberry (Arctostaphylylos UVA URSI) leaf, extract of Naemorhedi (Mitracarpus SCABER), sodium metabisulfite, and biotin;
the cosmetic auxiliary material matrix comprises a humectant, a chelating agent, a thickening agent, an emollient, a skin conditioner, a solubilizer, an essence, a preservative and water;
s2, adding water, a humectant, a chelating agent and a thickening agent into a water phase pot, heating to 80-85 ℃, and uniformly stirring and dispersing to obtain a phase A;
s3, adding the emollient into the oil phase pot, heating to 75-80 ℃, and uniformly stirring and dispersing to obtain phase B;
s4, pumping the phase A obtained in the step 1) and the phase B obtained in the step 2) into an emulsifying pot, homogenizing at a high speed for 5-10 minutes, starting cooling circulating water, stirring and cooling, adding a skin conditioner, the nicotinamide, the citrus peel extract, the arbutin, the whitening compound 1, the whitening compound 2, a solubilizer, an essence and a preservative into the emulsifying pot when the temperature is reduced to 40-45 ℃, and homogenizing for 1-3 minutes;
and S5, continuously stirring and cooling until the temperature is lower than 38 ℃, stopping stirring, and discharging after the detection is qualified.
Compared with the prior art, the invention has the beneficial effects that:
(1) the skin-care gels with the synergistic whitening effect comprise, by mass, 1.0-3.0% of nicotinamide, 0.5-1.5% of citrus peel extract, 0.1-0.5% of arbutin, 1.0-4.0% of whitening compound 1, 0.5-5.0% of whitening compound 2 and 86.0-96.9% of cosmetic auxiliary material matrix, and can avoid the skin from obtaining negative feedback signals such as melanin reduction and melanin requirement and the like due to the sudden enhancement of signals of a certain whitening node.
(2) The preparation method of the skin care gel with the synergistic whitening effect is simple, convenient and quick.
Drawings
Embodiments of the present invention are described in further detail with reference to the drawings, in which:
fig. 1 is a flowchart of a method for preparing a skin care gel having a synergistic whitening effect according to the present invention.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
The invention discloses skin-care gels with a synergistic whitening effect, which comprise the following components in percentage by mass:
wherein the whitening complex 1 comprises water, butylene glycol, arbutin, citric acid, sodium sulfite, acetyl tyrosine, strawberry saxifrage extract, peony root extract, aminopropanol ascorbic acid phosphate, scutellaria root extract, glutathione, hydrolyzed cherry plum;
the whitening compound 2 comprises glycerin, butylene glycol, extract of bearberry (Arctostaphylylos UVA URSI) leaf, extract of Psidium guajava (MITARCARPUS SCABER), sodium metabisulfite, and biotin.
Various test instruments and reagents are all commercial products and can be purchased through commercial approaches; wherein, the nicotinamide is a cosmetic raw material with nicotinic acid content less than 100 PPM; the total flavone content of the citrus peel extract is more than 2.5%; the arbutin is a cosmetic grade material with the content of more than 98 percent.
Examples 1 to 4
The raw material composition ratios of the skin care gels having the synergistic whitening effect of example 1, example 2, example 3 and example 4 are shown in table 1.
TABLE 1 Components of examples 1-4
Wherein, the components of the whitening compound 1 are shown in table 2.
Table 2 components of whitening complex 1
Component name | Content (wt.) |
Water (W) | 48.9930g |
Butanediol | 48.7511g |
Arbutin | 0.4750g |
Citric acid | 0.4750g |
Sodium sulfite | 0.4750g |
Acetyl tyrosine | 0.1425g |
Strawberry saxifrage extract | 0.1188g |
Peony root extract | 0.0855g |
Aminopropanol ascorbic acid phosphate ester | 0.04725g |
Scutellaria root extract | 0.0428g |
Glutathione | 0.0048g |
Hydrolyzed cherry plum | 0.3890g |
Wherein, the components of the whitening complex 2 are shown in table 3.
Table 3 components of whitening complex 2
The preparation method of skin care gels with synergistic whitening effect in examples 1-4 comprises the following steps:
1) compounding the raw material components as shown in table 1;
2) putting deionized water into a water phase pot, adding carbomer and acryloyl dimethyl ammonium taurate/VP copolymer, stirring until swelling completely, adding xanthan gum and hyaluronic acid pre-dispersed with 1.3-butanediol and glycerol, adding EDTA-2NA and allantoin, heating to 85 deg.C, keeping the temperature, and stirring for 20 min to obtain phase A;
3) adding polydimethylsiloxane and hydrogenated polyisobutene into an oil phase pot, heating to 80 ℃, and uniformly stirring and dispersing to obtain a phase B;
4) pumping the phase A obtained in the step 2) and the phase B obtained in the step 3) into an emulsifying pot, stirring and homogenizing for 5 minutes, starting cooling water, stirring and cooling to 45 ℃, adding triethanolamine, arbutin, nicotinamide, the whitening compound 1, the citrus peel extract, the whitening compound 2, the solubilizer, the essence, the solubilizer and the preservative, and homogenizing for 1 minute;
5) continuously stirring and cooling to the temperature lower than 38 ℃, and discharging after the inspection is qualified.
Wherein, the whitening compound 1 is prepared according to the table 2, and the whitening compound 2 is prepared according to the table 3.
Comparative examples 1 to 6
The skin care gels of comparative examples 1 to 6 had the raw material composition ratios shown in Table 4.
TABLE 4 Components of comparative examples 1-6
The preparation methods of the skin care gels of comparative examples 1 to 6 are the same as in example 1, and the formulations of the whitening complex 1 and the whitening complex 2 are shown in tables 2 and 3 of example 1.
Comparative examples 7 to 12
The skin care gels of comparative examples 7 to 12 had the raw material composition ratios shown in Table 5.
TABLE 5 Components of comparative examples 7-12
The skin care gels of comparative examples 7-12 were prepared as in example 1, and the formulation of whitening complex 1 is shown in table 2 of example 1.
Comparative examples 13 to 17
The skin care gels of comparative examples 13 to 17 had the raw material composition ratios shown in Table 6.
TABLE 6 Components of comparative examples 13 to 17
The skin care gels of comparative examples 13-17 were prepared as in example 1, and the formulation of whitening complex 1 is shown in table 2 of example 1.
Safety test
1. The number of tested persons: 30 persons in total, 3 men and 27 women; minimum age: 24 years old, maximum age: age 45 years old; mean age 35.73 ± 7.15 years volunteer enrollment criteria;
2. the test method comprises the following steps: examples 1-4 were tested for patch. Selecting a qualified spot tester, placing about 0.020-0.025 mL of a tested object into the spot tester by using a closed spot test method, externally applying a medical adhesive tape to the back of the tested object, removing the tested object after 24 hours, observing skin reactions 0.5, 24 and 48 hours after the spot is removed, and recording the results according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).
3. The evaluation criteria are shown in Table 7 below.
TABLE 7 evaluation criteria
Through determination, the result of the skin closed patch test on human body shows that 0 cases of 30 persons in comparison table 7 have positive reaction, and the test object does not cause adverse skin reaction to the batch of test subjects according to the regulation in technical Specification for cosmetic safety (2015 edition).
Stability test
1. Stability test samples: the product of example 3;
2. the test method comprises the following steps: the internal control standard (illumination for 1 month and high and low temperature test for 3 months) is higher than the national standard and the industrial standard;
3. the test results are shown in table 8.
Table 8 example 3 product test results
The results in table 8 show: the skin care gel of the present invention has good stability.
Examples of Effect test
1. The tester: 190 healthy women (25-45 years old) were divided into 19 groups of 10 persons each, each group using the same formula;
2. test area: face (left face blank, right face control sample or example sample; among them, the blanks of examples 1-3, comparative examples 1-5 are comparative example 6; the blanks of examples 4, comparative examples 6-16 are comparative example 17);
3. use of: twice a day in the morning and evening for 4 weeks;
4. testing an instrument: delfin skincolorlatch (finland);
5. the effect indexes are as follows: the change in color brightness (Δ L) and the ITA degree were measured, and the L value (brightness) and the ITA degree (color individual type angle) were mainly used as indices in the present invention. The test results are shown in table 10.
(1) Equation: Δ L ═ L (after 1 month of test on control or example product) -L (before start of test) ] - [ L ═ L (after 1 month of test on blank) -L (before start of test);
(2) the ITA degree (representing the overall change in chromaticity, the larger the ITA degree value, the lighter the skin color) is, as shown in Table 9.
TABLE 9 ITA degree
ITA degree range | |
55–90 | Very shallow Very light |
41–54 | Light shallow |
28–40 | Intermediate, etc |
10–27 | Tanned tanning |
-30–9 | Brown color of Brown |
-90–-29 | -29 Dark color of Dark color |
TABLE 10 test results
As can be seen from table 10, the skin care gel with synergistic whitening effect of the present invention has relatively significant whitening and brightening effects through the synergistic effect of the components, and the whitening effect is more significant than that of the comparative example containing only , two, three or four components in combination.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (8)
1, skin-care gel with a synergistic whitening effect, which is characterized by comprising the following components in percentage by mass:
46.3-50.0% of water, 40.0-50.0% of butanediol, 0.3-0.8% of arbutin, 0.3-0.6% of citric acid, 0.4-0.6% of sodium sulfite, 0.1-0.3% of acetyltyrosine, 0.01-0.3% of strawberry saxifrage extract, 0.01-0.2% of peony root extract, 0.001-0.1% of aminopropanol ascorbic acid phosphate ester, 0.01-0.1% of scutellaria root extract, 0.001-0.1% of glutathione and 0.01-0.6% of hydrolyzed cherry plum;
20.5 to 5.0 percent of whitening compound; the whitening compound 2 comprises the following components in percentage by mass:
45.0-65.0% of glycerin, 10.0-30.0% of butanediol, 5.0-15.0% of bearberry (Arctostaphylylos UVAURSI) leaf extract, 5.0-10.0% of fructus Toosendan (MITRACARUPUS SCABER) extract, 0.01-0.1% of sodium metabisulfite, 0.001-0.01% of biotin;
86.0-96.9% of cosmetic auxiliary material matrix.
3. the skin care gel with the synergistic whitening effect according to claim 1, characterized in that: the cosmetic auxiliary material matrix comprises the following components in percentage by mass:
1.0-30.0% of humectant, 0.01-2.0% of chelating agent, 0.05-5.0% of thickening agent, 0.1-40.0% of emollient, 0.01-37.0% of skin conditioning agent, 0.01-1.0% of solubilizer, 0.01-1.0% of essence, 0.01-1.0% of preservative and 20.0-98.0% of water.
4. The skin care gel with synergistic whitening effect according to claim 1, wherein the humectant is or more selected from glycerin, propylene glycol, 1, 3-propanediol, butylene glycol, hexylene glycol, 1, 2-pentanediol, caprylyl glycol, allantoin, sorbitol, betaine;
the chelating agent is or more of disodium EDTA, tetrasodium EDTA, citric acid and sodium citrate;
the thickening agent is or more of acryloyl dimethyl taurate/VP copolymer, sodium polyacrylate, acrylic acid (ester) copolymer sodium, hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer, polyacrylate-13, acryloyl dimethyl taurate/behenyl alcohol polyether-25 methacrylate cross-linked polymer and hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer;
the emollient is or more of mineral oil, isohexadecane, shea butter, olive oil, polydimethylsiloxane, caprylic/capric triglyceride, tri (ethyl hexanoate) glyceride, squalane, ethylhexyl palmitate, hydrogenated polydecene, cyclopentadecyldimethyl siloxane, and cyclohexasiloxane;
the skin conditioner is α -mannan, sodium hyaluronate, sodium PCA, betaine, polyquaternium-51, fructan, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, Chondrus CRISPUS (Chondrus CRISPUS) extract, chitosan, β -dextran, and creatine or more.
5. The skin care gel with the synergistic whitening effect according to claim 1, characterized in that: the nicotinamide is a cosmetic raw material with nicotinic acid content less than 100 PPM.
6. The skin care gel with the synergistic whitening effect according to claim 1, characterized in that: the citrus peel extract adopts a carbon dioxide supercritical extraction technology, and the total flavone content of the citrus peel extract is more than 2.5%.
7. The skin care gel with the synergistic whitening effect according to claim 1, characterized in that: the arbutin is a cosmetic grade raw material with the content of more than 98 percent.
8, method for preparing skin care gel with synergistic whitening effect according to any of claims 1-7, characterized by comprising the following steps:
s1, batching: preparing the following raw material components in percentage by mass: 1.0-3.0% of nicotinamide, 0.5-1.5% of citrus peel extract, 0.1-0.5% of arbutin, 1.0-4.0% of whitening compound 1, 0.5-5.0% of whitening compound 2 and 86.0-96.9% of cosmetic auxiliary material matrix;
wherein the whitening complex 1 comprises water, butylene glycol, arbutin, citric acid, sodium sulfite, acetyl tyrosine, strawberry saxifrage extract, peony root extract, aminopropanol ascorbic acid phosphate, scutellaria root extract, glutathione, hydrolyzed cherry plum;
the whitening compound 2 comprises glycerin, butylene glycol, extract of bearberry (Arctostaphylylos UVA URSI) leaf, extract of Naemorhedi (Mitracarpus SCABER), sodium metabisulfite, and biotin;
the cosmetic auxiliary material matrix comprises a humectant, a chelating agent, a thickening agent, an emollient, a skin conditioner, a solubilizer, an essence, a preservative and water;
s2, adding water, a humectant, a chelating agent and a thickening agent into a water phase pot, heating to 80-85 ℃, and uniformly stirring and dispersing to obtain a phase A;
s3, adding the emollient into the oil phase pot, heating to 75-80 ℃, and uniformly stirring and dispersing to obtain phase B;
s4, pumping the phase A obtained in the step 1) and the phase B obtained in the step 2) into an emulsifying pot, homogenizing at a high speed for 5-10 minutes, starting cooling circulating water, stirring and cooling, adding a skin conditioner, the nicotinamide, the citrus peel extract, the arbutin, the whitening compound 1, the whitening compound 2, a solubilizer, an essence and a preservative into the emulsifying pot when the temperature is reduced to 40-45 ℃, and homogenizing for 1-3 minutes;
and S5, continuously stirring and cooling until the temperature is lower than 38 ℃, stopping stirring, and discharging after the detection is qualified.
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CN110478287A (en) * | 2019-08-14 | 2019-11-22 | 广州睿晞生化科技有限公司 | It is a kind of can whitening Eradicates Huang skin lightening composition |
CN114224752A (en) * | 2022-01-13 | 2022-03-25 | 南京昂谷医药科技有限公司 | Preparation and application of Lanqin gel |
CN115944577A (en) * | 2022-12-29 | 2023-04-11 | 羽楠(广州)化妆品有限公司 | Whitening composition and application thereof, whitening cosmetic and preparation method thereof |
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