CN115120532A - Skin-care cream and preparation method thereof - Google Patents
Skin-care cream and preparation method thereof Download PDFInfo
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- CN115120532A CN115120532A CN202210999186.0A CN202210999186A CN115120532A CN 115120532 A CN115120532 A CN 115120532A CN 202210999186 A CN202210999186 A CN 202210999186A CN 115120532 A CN115120532 A CN 115120532A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The application discloses a skin care cream, which relates to the field of personal care products and comprises the following preparation components in percentage by weight: phase A: 0.005-0.02% of medium molecular hyaluronic acid and/or salt thereof; 0.005-0.02% of low molecular weight hyaluronic acid and/or salt thereof; 0.001-0.01% of acetylated hyaluronic acid and/or salt thereof; 0.5 to 3 percent of betaine; 0.8-2.5% of polyacrylate cross-linked polymer; 5-20% of a polyhydric alcohol humectant; 0.01 to 0.05 percent of chelating agent; the balance of water; phase B: 0.5 to 2.5 percent of cyclic polyorganosiloxane; and phase C: 0.1 to 1.0 percent of p-hydroxyacetophenone; 0.1 to 1.0 percent of 1, 2-hexanediol; wherein the content of the emulsifier is 0%. The application has the effect of preparing the skin cream without the emulsifier.
Description
Technical Field
The application relates to the field of personal care products, in particular to a skin care cream and a preparation method thereof.
Background
The skin cream is an emulsified product with skin care effect, which refers to a solid or semi-solid emulsified product, and is an emulsified body, and the design of an emulsifying system is also the most critical link of cream skin care or cosmetics, and the advantages and disadvantages of the emulsified product directly influence the stability, appearance and skin feel of the product, and further influence the quality, price and the like of the cream product, so that the raw materials of the skin cream usually comprise emulsifier raw materials, and in addition, the raw materials of grease, water, thickening agent, humectant, preservative and the like are generally added.
The emulsifier is a surface active substance, has both hydrophilic group and hydrophilic group in the molecule, and is gathered on an oil-water interface to reduce interfacial tension and reduce energy required for forming emulsion, so as to form a firm emulsion film to form stable emulsion.
In view of the above-mentioned related technologies, in the production process of skin cream, the addition of emulsifier increases the raw material cost of skin cream, and increases the difficulty and time consumption of the preparation process, so it is to be improved.
Disclosure of Invention
In order to prepare a skin cream without an emulsifier, the application provides a skin cream and a preparation method thereof.
In a first aspect, the skin care cream provided by the application adopts the following technical scheme:
the skin-care cream comprises the following preparation components in percentage by weight:
phase A: 0.005-0.02% of medium molecular hyaluronic acid and/or salt thereof; 0.005-0.02% of low molecular weight hyaluronic acid and/or salt thereof; 0.001-0.01% of acetylated hyaluronic acid and/or salt thereof; 0.5 to 3 percent of betaine; 0.8-2.5% of polyacrylate cross-linked polymer; 5-20% of polyalcohol humectant; 0.01 to 0.05 percent of chelating agent; the balance of water;
phase B: 0.5 to 2.5 percent of cyclic polyorganosiloxane; and
and C phase: 0.1 to 1.0 percent of p-hydroxyacetophenone; 0.1 to 1.0 percent of 1, 2-hexanediol;
wherein the content of the emulsifier is 0%.
By adopting the technical scheme, the dosage of the thickening agent-polyacrylate cross-linked polymer is increased, and the polyacrylate cross-linked polymer and the betaine are compounded to play a role in synergistic emulsification, so that the skin cream can form a stable emulsification system without using an emulsifier;
the polyacrylate crosslinked polymer is a high molecular polymer, has larger molecular chains, is used as a thickening agent and a film forming agent in cosmetics, contains hydrophilic groups and hydrophobic groups, the hydrophilic groups can adsorb a large amount of water molecules around, so that the viscosity of the system is increased, and the hydrophobic groups can be easily associated with oil phase components due to hydrophobic effect, so that oil drops are uniformly distributed in a space with higher viscosity, and the emulsion stability of the system is enhanced;
the betaine is a mild amphoteric surfactant, contains hydrophilic groups and hydrophobic groups, can be adsorbed on the surface of water and oil, remarkably reduces the interfacial tension between two phases, and improves the suspension stability of oil drops;
moreover, quaternary ammonium inner salt type zwitterionic monomers with both anionic property and cationic property in the betaine can be adsorbed and arranged on a macromolecular chain of the polyacrylate cross-linked polymer, and the betaine structures of the macromolecular chain of the copolymer can form dipole force through the mutual attraction of positive charges and negative charges, so that the acting force among the molecular chains is enhanced, the mutual accumulation of oil drops is reduced, and the suspension stability of the oil drops in a system is improved;
meanwhile, acetylated hyaluronic acid and/or salt thereof is added, the acetylated hyaluronic acid and/or salt thereof is prepared by acetylation of natural moisturizing factor hyaluronic acid, and acetyl is introduced, so that the acetylated hyaluronic acid and/or salt thereof has hydrophilicity and lipophilicity, and can play a role in doubling moisturizing, repairing stratum corneum barrier, improving skin elasticity and the like;
therefore, the skin care cream prepared by the invention is free of emulsifier, safe, environment-friendly, mild and non-irritant to skin, fresh and cool in skin feel, moistening and moisturizing, translucent, simple in preparation process, low in preparation cost and good in popularization, and does not need heating in production.
Preferably, the paint consists of the following preparation components in percentage by weight:
phase A: 0.013% of middle molecular hyaluronic acid and/or salt thereof; 0.013% of low-molecular hyaluronic acid and/or salt thereof; 0.004% of acetylated hyaluronic acid and/or salt thereof; 2% of betaine; polyacrylate crosspolymer-61.5%; 5% of glycerol; 5% of propylene glycol; 0.03 percent of EDTA disodium; the balance of deionized water;
phase B: 1.5% of a mixture of cyclohexasiloxane and cyclopentasiloxane; and
and C phase: 0.5 percent of p-hydroxyacetophenone; 0.5% of 1, 2-hexanediol.
Preferably, the molecular weight of the medium molecular hyaluronic acid and/or the salt thereof is between 60 and 100 kilodaltons, for example, the molecular weight of the medium molecular hyaluronic acid and/or the salt thereof may be between 60 kilodaltons, 70 kilodaltons, 80 kilodaltons, 90 kilodaltons, 100 kilodaltons, and the molecular weight of the low molecular hyaluronic acid and/or the salt thereof may be between 20 and 40 kilodaltons, for example, the molecular weight of the low molecular hyaluronic acid and/or the salt thereof may be between 20 kilodaltons, 25 kilodaltons, 30 kilodaltons, 35 kilodaltons, 40 kilodaltons.
By adopting the technical scheme, the high molecular weight hyaluronic acid and/or the salt thereof has the characteristic of high viscosity, so that the hyaluronic acid and/or the salt thereof can generate sticky feeling during smearing, is not easily and quickly absorbed by skin, and cannot achieve the effect of well preventing water in the skin from evaporating, so that the hyaluronic acid and/or the salt thereof with medium and low molecular weights can show long-term moisturizing property and obtain excellent skin feeling.
Preferably, the acetyl content of the acetylated hyaluronic acid and/or salt thereof is 15-30wt%, for example the acetyl content may be 15 wt%, 17 wt%, 19 wt%, 21 wt%, 23 wt%, 25 wt%, 27 wt%, 29 wt%.
By adopting the technical scheme, a certain amount of acetyl is introduced to the hyaluronic acid and/or the salt thereof as a hydrophobic group, so that the acetylated hyaluronic acid and/or the salt thereof has both hydrophilicity and lipophilicity and can be adsorbed on a water-oil interface.
Preferably, the polyhydric alcohol humectant comprises one or more of glycerin, propylene glycol, 1, 3-butanediol and sorbitol.
By adopting the technical scheme, the polyalcohol moisturizing agent is a hydrophilic substance, contains hydroxyl, can form hydrogen bonds with water molecules, binds water, and moisturizes by enhancing the water absorption of the skin cuticle and the water binding capacity.
Preferably, the chelating agent comprises disodium EDTA and/or tetrasodium EDTA.
Preferably, the cyclic polyorganosiloxane includes one or more of cyclohexasiloxane, cyclopentasiloxane, and cyclopentadimethicone.
By adopting the technical scheme, the cyclic polyorganosiloxane is an organosilicon polymer with appropriate volatile substances, has higher intermiscibility with other cosmetic raw materials, is light and fresh in texture, is not greasy, can improve the touch feeling, and has no long-term residue.
In a second aspect, the preparation method of the skin cream provided by the application adopts the following preparation steps:
s1: weighing each phase A component according to the component proportion, and mixing to obtain a first mixture;
s2: weighing all the B-phase components according to the component proportion, mixing, and adding the mixed B-phase components into the first mixture to obtain a second mixture;
s3: and weighing all the C-phase components according to the component proportion, mixing, adding the mixed C-phase components into the second mixture, and preparing the skin-care cream.
In summary, the present application includes at least one of the following beneficial technical effects:
(1) according to the invention, the dosage of the polyacrylate cross-linked polymer is increased, the polyacrylate cross-linked polymer and the betaine are compounded to play a role in synergistic emulsification, and the acetylated hyaluronic acid and/or the salt thereof are added, so that the skin cream can form a stable emulsification system without using an emulsifier;
(2) the invention adopts the hyaluronic acid and/or the salt thereof with medium and low molecular weight, can show long-time moisture-keeping property, well solves the sticky feeling of the hyaluronic acid and/or the salt thereof with high molecular weight, and obtains excellent skin feeling;
(3) the skin care cream prepared by the invention is safe and environment-friendly, is mild and non-irritant to skin, has fresh and cool skin feel, is moist and moisturized, is semitransparent, does not need to be heated during production, and has the advantages of simple preparation process, low preparation cost and good popularization.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
Example 1:
the method comprises the following steps: weighing 0.013% of middle molecular sodium hyaluronate with the molecular weight of 70 ten thousand daltons, 0.013% of low molecular sodium hyaluronate with the molecular weight of 20 ten thousand daltons, 0.004% of sodium acetylated hyaluronate (the acetyl content is 25 wt%), 2% of betaine, 1.5% of polyacrylate cross-linked polymer-6, 5% of glycerol, 5% of propylene glycol, 0.03% of disodium EDTA and 83.44% of deionized water according to the component proportion, mixing, adding into a stirring kettle, starting homogenizing and stirring for 10min until the particles are completely dissolved, and obtaining a first mixture;
step two: weighing 1.5% of DC345 cyclohexasiloxane and cyclopentasiloxane according to the component proportion, adding the mixture into the first mixture, starting homogenizing and stirring for 10min until the particles are completely dissolved, and obtaining a second mixture;
step three: weighing 0.5% of p-hydroxyacetophenone and 0.5% of 1, 2-hexanediol according to the component proportion, mixing, adding into the second mixture, homogenizing and stirring for 10min until the particles are completely dissolved, and preparing the skin care cream.
Example 2:
this example is different from example 1 in that 0.009% of medium molecular sodium hyaluronate, 0.009% of low molecular sodium hyaluronate, 0.003% of acetylated sodium hyaluronate, 1.5% of betaine, 61.3% of polyacrylate crosspolymer, 3.5% of glycerin, 3.5% of propylene glycol, 0.02% of disodium EDTA, 88.46% of deionized water, 1.0% of DC345 cyclohexasiloxane and cyclopentasiloxane, 0.35% of p-hydroxyacetophenone, and 0.35% of 1, 2-hexanediol, and the rest was the same as example 1.
Example 3:
this example is different from example 1 in that 0.005% of medium molecular sodium hyaluronate, 0.005% of low molecular sodium hyaluronate, 0.001% of acetylated sodium hyaluronate, 0.5% of betaine, 61.0% of polyacrylate crosslinked polymer, 2.5% of glycerin, 2.5% of propylene glycol, 0.01% of disodium EDTA, 92.48% of deionized water, 0.5% of DC345 cyclohexasiloxane and cyclopentasiloxane, 0.25% of p-hydroxyacetophenone, and 0.25% of 1, 2-hexanediol, and the rest is the same as example 1.
Example 4:
this example is different from example 1 in that 0.02% of medium molecular sodium hyaluronate, 0.02% of low molecular sodium hyaluronate, 0.01% of acetylated sodium hyaluronate, 3% of betaine, 62.5% of polyacrylate cross-linked polymer, 10% of glycerin, 10% of propylene glycol, 0.05% of disodium EDTA, 69.9% of deionized water, 2.5% of DC345 cyclohexasiloxane and cyclopentasiloxane, 1% of p-hydroxyacetophenone, and 1% of 1, 2-hexanediol, and the rest is the same as example 1.
Example 5:
this example is different from example 1 in that 0.002% of acetylated sodium hyaluronate, 83.94% of deionized water, and the rest is the same as example 1.
Example 6:
this example differs from example 1 in that betaine 1%, deionized water 84.94%, and the rest is the same as example 1.
Example 7:
this example is different from example 1 in that the polyacrylate crosslinked polymer was-61.1%, the deionized water was 84.34%, and the rest was the same as example 1.
Example 8:
the difference between this example and example 1 is that the medium molecular sodium hyaluronate 0.007%, the low molecular sodium hyaluronate 0.007%, the deionized water 83.95%, and the rest are the same as example 1.
The weight percentages of the components of the skin cream prepared in examples 1-8 are shown in table 1:
TABLE 1
Comparative example 1:
the method comprises the following steps: weighing 0.013% of medium molecular sodium hyaluronate with the molecular weight of 70 ten thousand daltons, 0.013% of low molecular sodium hyaluronate with the molecular weight of 20 ten thousand daltons, 3.504% of arachidyl alcohol (and) behenyl alcohol (and) arachidyl alcohol glucoside, 5% of glycerol, 5% of propylene glycol, 0.03% of disodium EDTA and 88.94% of deionized water according to the component proportion, mixing, adding into a stirring kettle, starting homogenizing and stirring for 10min until the particles are completely dissolved to obtain a first mixture;
step two: weighing 1.5% of DC345 cyclohexasiloxane and cyclopentasiloxane according to the component proportion, adding the mixture into the first mixture, starting homogenizing and stirring for 10min until the particles are completely dissolved, and obtaining a second mixture;
step three: weighing 0.5% of p-hydroxyacetophenone and 0.5% of 1, 2-hexanediol according to the component proportion, mixing, adding into the second mixture, starting homogenizing and stirring for 10min until the particles are completely dissolved, and preparing the skin care cream.
Comparative example 2:
the method comprises the following steps: weighing 0.013% of medium molecular sodium hyaluronate with the molecular weight of 70 ten thousand daltons, 0.013% of low molecular sodium hyaluronate with the molecular weight of 20 ten thousand daltons, 0.004% of sodium hyaluronate with the acetyl content of 25 wt%, 1.5% of polyacrylate cross-linked polymer-6, 5% of glycerol, 5% of propylene glycol, 0.03% of disodium EDTA and 85.44% of deionized water according to the component proportion, mixing, adding into a stirring kettle, starting homogenizing and stirring for 10min until the particles are completely dissolved, and obtaining a first mixture;
step two: weighing 1.5% of DC345 cyclohexasiloxane and cyclopentasiloxane according to the component proportion, adding the mixture into the first mixture, starting homogenizing and stirring for 10min until the particles are completely dissolved, and obtaining a second mixture;
step three: weighing 0.5% of p-hydroxyacetophenone and 0.5% of 1, 2-hexanediol according to the component proportion, mixing, adding into the second mixture, homogenizing and stirring for 10min until the particles are completely dissolved, and preparing the skin care cream.
Comparative example 3:
this comparative example differs from comparative example 2 in that polyacrylate crosslinked polymer-60%, betaine-2%, deionized water 84.84%, and the remainder were the same as comparative example 2.
Comparative example 4:
the difference between the comparative example and the comparative example 2 is that 0 percent of sodium hyaluronate with medium molecule, 0 percent of sodium hyaluronate with low molecule, 0.026 percent of sodium hyaluronate with high molecule of 150 kilodalton, 2 percent of betaine and the rest are the same as the comparative example 2.
And (3) performance inspection and test:
(1) and (3) testing the emulsion stability: the skin cream prepared in examples 1 to 8 and comparative examples 1 to 4 were respectively filled in transparent plastic bottles, 10 testers were selected, whether oil-water stratification occurred in the skin cream after standing for 1 day, 15 days and 90 days was respectively observed by using an electron scanning microscope, and the emulsion stability of the skin cream was scored, with a score of 5 being adopted as a scoring criterion, 1 being the worst, and 5 being the best, with the evaluation result being the average score of all testers, the higher the average score is, the oil-water stratification is indicated, and the better the emulsion stability is.
(2) And (4) testing the moisturizing effect: 10 test subjects were selected to test the skin cream prepared in examples 1 to 8 and comparative examples 1 to 4, marking a painted area on the inner side of the left forearm of the test subject with a marker pen, and testing and recording the moisture value L1 of the painted area with a skin tester; then, the sample application area is applied once according to the dosage of a (2.0 +/-0.1) mg/cm2 test sample, the whole process is carried out in a constant temperature and humidity environment, after 120min, the moisture value L2 of the sample application area is tested again by a skin tester and recorded, and the moisture content increase rate is obtained, wherein the calculation formula of the moisture content increase rate is as follows: the moisture content increase rate was (L2-L1)/L1.
The results of the performance test of examples 1-8 and comparative examples 1-4 are shown in table 2:
TABLE 2
(1) As can be seen from the comparison between examples 1-7 and comparative examples 1-3, in the scheme, the polyacrylate crosslinked polymer-6 and the betaine are selected for compounding, and the acetylated sodium hyaluronate is added, so that an emulsifying system which is equal to or slightly superior to the emulsifying agent can be constructed, the cost of the prepared skin cream is saved, and the preparation process is simplified on the premise of ensuring a good emulsifying system.
(2) As can be seen from the comparison among examples 1 and 8 and comparative example 4, sodium hyaluronate with medium and low molecular weights is selected in the present invention, and can moisturize the skin for a longer time than sodium hyaluronate with high molecular weight.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (8)
1. The skin cream is characterized by comprising the following preparation components in percentage by weight:
phase A: 0.005-0.02% of medium molecular hyaluronic acid and/or salt thereof; 0.005-0.02% of low molecular weight hyaluronic acid and/or salt thereof; 0.001-0.01% of acetylated hyaluronic acid and/or salt thereof; 0.5 to 3 percent of betaine; 0.8-2.5% of polyacrylate cross-linked polymer; 5-20% of polyalcohol humectant; 0.01 to 0.05 percent of chelating agent; the balance of water;
phase B: 0.5 to 2.5 percent of cyclic polyorganosiloxane; and
and C phase: 0.1 to 1.0 percent of p-hydroxyacetophenone; 0.1 to 1.0 percent of 1, 2-hexanediol;
wherein the content of the emulsifier is 0%.
2. The skin cream according to claim 1, characterized by consisting of the following preparation components in weight percent:
phase A: 0.013% of middle molecular hyaluronic acid and/or salt thereof; 0.013% of low-molecular hyaluronic acid and/or salt thereof; 0.004% of acetylated hyaluronic acid and/or salt thereof; 2% of betaine; polyacrylate crosspolymer-61.5%; 5% of glycerol; 5% of propylene glycol; 0.03 percent of EDTA disodium; the balance of deionized water;
phase B: 1.5% of a mixture of cyclohexasiloxane and cyclopentasiloxane; and
and C phase: 0.5 percent of p-hydroxyacetophenone; 0.5 percent of 1, 2-hexanediol.
3. The skin cream of claim 1, wherein the medium molecular hyaluronic acid and/or salt thereof has a molecular weight of 60-100 kilodaltons and the low molecular hyaluronic acid and/or salt thereof has a molecular weight of 20-40 kilodaltons.
4. The skin cream according to claim 1, wherein the acetylated hyaluronic acid and/or salt thereof has an acetyl content of 15-30 wt%.
5. The skin cream of claim 1, wherein the polyhydric alcohol humectant comprises one or more of glycerin, propylene glycol, 1, 3-butylene glycol, and sorbitol.
6. The skin cream of claim 1, wherein the chelating agent comprises disodium EDTA and/or tetrasodium EDTA.
7. The skin cream of claim 1, wherein the cyclic polyorganosiloxane comprises one or more of cyclohexasiloxane, cyclopentasiloxane, cyclopentadimethicone.
8. A method of preparing a skin cream according to any one of claims 1 to 7, comprising the steps of:
s1: the skin cream according to any one of claims 1-7, wherein each phase A component is weighed and mixed to obtain a first mixture;
s2: weighing all the phase B components according to the component proportion, mixing, and adding the mixed phase B components into the first mixture to obtain a second mixture;
s3: and weighing all the C-phase components according to the component proportion, mixing, adding the mixed C-phase components into the second mixture, and preparing the skin-care cream.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737517A (en) * | 2022-11-28 | 2023-03-07 | 上海臻臣化妆品有限公司 | Moisturizing face cream |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104116650A (en) * | 2014-08-11 | 2014-10-29 | 上海贝泰妮生物科技有限公司 | Cream preparation with high oil phase content and no emulsifier and preparation method of cream preparation |
| KR20150123132A (en) * | 2014-04-24 | 2015-11-03 | 주식회사 엘지생활건강 | Cosmetic composition comprising high-content of calcium pantothenate and manufacturing method thereof |
| US20170224596A1 (en) * | 2014-07-31 | 2017-08-10 | Kimberly-Clark Worldwide, Inc. | Anti-adherent alcohol-based composition |
| CN109172435A (en) * | 2018-10-23 | 2019-01-11 | 广州艾蓓生物科技有限公司 | A kind of bean curd frost and preparation method thereof |
| CN110302063A (en) * | 2019-07-05 | 2019-10-08 | 中山中研化妆品有限公司 | A kind of Moisturizer containing layered liquid crystal bionic structure film |
| US20200246229A1 (en) * | 2017-08-07 | 2020-08-06 | Shiseido Company, Ltd. | Powder containing water-based composition and external skin preparation |
| CN113069393A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Eye cream and preparation method thereof |
| CN113274312A (en) * | 2021-06-02 | 2021-08-20 | 上海活彩生物科技有限公司 | Essence for improving skin aging and injury and preparation method thereof |
| CN113576934A (en) * | 2021-08-23 | 2021-11-02 | 上海晶典化妆品有限公司 | Fresh skin-caring and skin-activating essence stock solution and preparation method thereof |
| US20210369583A1 (en) * | 2018-02-26 | 2021-12-02 | Danisco Us Inc. | Compositions for providing skin care benefits and methods of use |
| CN113749954A (en) * | 2020-06-07 | 2021-12-07 | 美歆然化妆品(上海)有限公司 | Essence cream and preparation method thereof |
| CN114344180A (en) * | 2022-01-27 | 2022-04-15 | 仙婷(广州)科技研发有限公司 | Composition for improving skin condition and preparation method and application thereof |
| CN114848520A (en) * | 2022-06-20 | 2022-08-05 | 上海新高姿化妆品有限公司 | Whitening and repairing composition and application thereof |
-
2022
- 2022-08-19 CN CN202210999186.0A patent/CN115120532A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150123132A (en) * | 2014-04-24 | 2015-11-03 | 주식회사 엘지생활건강 | Cosmetic composition comprising high-content of calcium pantothenate and manufacturing method thereof |
| US20170224596A1 (en) * | 2014-07-31 | 2017-08-10 | Kimberly-Clark Worldwide, Inc. | Anti-adherent alcohol-based composition |
| CN104116650A (en) * | 2014-08-11 | 2014-10-29 | 上海贝泰妮生物科技有限公司 | Cream preparation with high oil phase content and no emulsifier and preparation method of cream preparation |
| US20200246229A1 (en) * | 2017-08-07 | 2020-08-06 | Shiseido Company, Ltd. | Powder containing water-based composition and external skin preparation |
| US20210369583A1 (en) * | 2018-02-26 | 2021-12-02 | Danisco Us Inc. | Compositions for providing skin care benefits and methods of use |
| CN109172435A (en) * | 2018-10-23 | 2019-01-11 | 广州艾蓓生物科技有限公司 | A kind of bean curd frost and preparation method thereof |
| CN110302063A (en) * | 2019-07-05 | 2019-10-08 | 中山中研化妆品有限公司 | A kind of Moisturizer containing layered liquid crystal bionic structure film |
| CN113069393A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Eye cream and preparation method thereof |
| CN113749954A (en) * | 2020-06-07 | 2021-12-07 | 美歆然化妆品(上海)有限公司 | Essence cream and preparation method thereof |
| CN113274312A (en) * | 2021-06-02 | 2021-08-20 | 上海活彩生物科技有限公司 | Essence for improving skin aging and injury and preparation method thereof |
| CN113576934A (en) * | 2021-08-23 | 2021-11-02 | 上海晶典化妆品有限公司 | Fresh skin-caring and skin-activating essence stock solution and preparation method thereof |
| CN114344180A (en) * | 2022-01-27 | 2022-04-15 | 仙婷(广州)科技研发有限公司 | Composition for improving skin condition and preparation method and application thereof |
| CN114848520A (en) * | 2022-06-20 | 2022-08-05 | 上海新高姿化妆品有限公司 | Whitening and repairing composition and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| XUE Y等: "Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether", RSC ADVANCES, vol. 10, no. 12, pages 7206 - 7213 * |
| 毛华、王海英等: "不同分子量透明质酸钠的保湿效果评价", 第九届中国化妆品学术研讨会论文集（上）, pages 19 - 22 * |
| 阅紫: "医用透明质酸钠的三种分子量与作用", pages 1, Retrieved from the Internet <URL:https://zhuanlan.zhihu.com/p/64064861?utm_id=0> * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737517A (en) * | 2022-11-28 | 2023-03-07 | 上海臻臣化妆品有限公司 | Moisturizing face cream |
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