CN110302063A - A kind of Moisturizer containing layered liquid crystal bionic structure film - Google Patents
A kind of Moisturizer containing layered liquid crystal bionic structure film Download PDFInfo
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- CN110302063A CN110302063A CN201910602108.0A CN201910602108A CN110302063A CN 110302063 A CN110302063 A CN 110302063A CN 201910602108 A CN201910602108 A CN 201910602108A CN 110302063 A CN110302063 A CN 110302063A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention proposes a kind of Moisturizer containing layered liquid crystal bionic structure film, it by mass percentage include following components: layered liquid crystal bionic structure membrane complex 1-10%, skin conditioning agent 1-10%, emollient 5-15%, Sodium Hyaluronate 0.01-0.05%, glycine betaine 1-3%, polyalcohol 8-27%, thickener 0.1-0.8%, emulsifier 0.5-2% and water 35%-70%；The layered bionical membrane complex of liquid crystal structure, comprising: ceramide, cholesterol and the fatty acid mixt of 0.1-10%, the liquid crystal emulsifier of 0.1-5%, 10-60% polyalcohol；Wherein ceramide, cholesterol, fatty acid molar ratio be 1:1:1~3:1:1.The present invention, which mentions, is dissolved into the layered liquid crystal bionic structure film that ceramide, cholesterol, fatty acid are formed in skin care item, improves the moisture-retaining capacity of skin, is effectively improved skin condition.
Description
Technical field
The present invention relates to cosmetic field more particularly to a kind of Moisturizers containing layered liquid crystal bionic structure film.
Background technique
The cuticula of skin is the outermost part of epidermis, mainly by 10 to 20 layers it is flat, do not have it is nucleolate dead thin
Born of the same parents' composition.When these cell detachments, the beneath cell positioned at basal layer, which can be brought to, to be come, and forms new cuticula.Work as cutin
When the water content of layer is lower than percent 15, skin has tight feeling, and it is de- to be easy decortication for skin when lower than percent 10
Bits.
Influence physiology lipid (ceramide, cholesterol, the fat for mainly forming skin barrier of epidermis moisture-retaining capacity
Acid).Ceramide, cholesterol, fatty acid are combined into long-chain and are folded into multilayer and formed in cell with equimolar ratio (1:1:1)
Thin layer corpusculum (liquid crystal structure), and be stored in cell, thin layer corpusculum releases (this from horn cell in the fullness of time
Process is referred to as exocytosis).The thin layer corpusculum gone out by exocytosis passes through the degradation of enzyme, obtain the ceramide of equimolar ratio, cholesterol,
Fatty acid exists between horn cell, maintains the balance of the water content of cuticula, keeps epidermis moisture-retaining capacity normal.So working as cutin
When the physiology lipid of cell is unbalance, especially ceramide lack the case where, will make skin moisture-keeping ability decline, cuticula
It excessively falls off, skin barrier is impaired, and then becomes fragile sensitive.
Summary of the invention
For the moisture-retaining capacity for improving skin, the present invention proposes a kind of preserving moisture and protecting skin containing layered liquid crystal bionic structure film
The layered liquid crystal bionic structure film that ceramide, cholesterol, fatty acid are formed is dissolved into skin care item, improves skin by product
Moisture-retaining capacity is effectively improved skin condition.
The present invention proposes a kind of Moisturizer containing layered liquid crystal bionic structure film, by mass percentage includes following
Component: layered liquid crystal bionic structure membrane complex 1-10%, skin conditioning agent 1-10%, emollient 5-15%, Sodium Hyaluronate
0.01-0.05%, glycine betaine 1-3%, polyalcohol 8-27%, thickener 0.1-0.8%, emulsifier 0.5-2% and water 35%-
70%；
The layered bionical membrane complex of liquid crystal structure includes: ceramide, the gallbladder of 0.1-10% by its mass percent
Sterol and fatty acid mixt, the liquid crystal emulsifier of 0.1-5%, the polyalcohol of 10-60%, chelating agent 0.05-0.1%, surplus
Water, the sum of each component are 100%；
In the ceramide, cholesterol and fatty acid mixt, the molar ratio of ceramide, cholesterol, fatty acid
For 1:1:1~3:1:1；Molar ratio is consistent with the ingredient of keratoderma intercellular lipid when being 1:1:1, is conducive to skin suction
It receives, ceramide is slightly above lipid binding unbalance in ratio Shi Keyu skin, promotes the recovery of skin epidermis moisture-retaining capacity.
Preferably, the ceramide include Cer EOS, Cer NS, Cer NP, in Cer AP II
It is a kind of, two or more.
Preferably, the liquid crystal emulsifier includes hydrolecithin hydrogenated lyso lecithin.It is two kinds of liquid crystal emulsified
Agent superposition uses, and is more advantageous to the stability for improving layered liquid crystal bionic structure film.
Preferably, the fatty acid includes one of palmitinic acid, stearic acid, isostearic acid, behenic acid, two kinds or more
Kind.
Preferably, polyalcohol include glycerol, it is dipropylene glycol, 1,3-BDO, a variety of in isoprene.
Preferably, the skin conditioning agent includes panthenol, tetrahydro methylpyrimidine carboxylic acid, two kinds or more in glycosphingolipids
Kind.
Panthenol, molecular weight is smaller, and cuticula can be effectively penetrated into after being absorbed by the skin, and increases the hyaluronic acid in skin
Content moisturizes the skin the cuticula on surface, plays the role of potent moisturizing, is effectively improved pachylosis, skin is made to become soft
There is certain antiinflammation simultaneously.
Tetrahydro methylpyrimidine carboxylic acid has very strong hydrone complexing power, can make the water-bound of cell free.It is general
Alcohol compounds the synthesis that can promote the hyaluronic acid of skin itself with tetrahydro methylpyrimidine carboxylic acid.
Glycosphingolipids are one of the ingredients for constituting cell membrane, durings cell adhesion, growth, differentiation, signal transduction etc.
It plays an important role.
Preferably, the emollient includes jojoba seed oil, silybin oil acetoacetic ester, phytosterols oletate and fertility
One of phenol, two or more.The emollient in preferred plant source reduces stimulation of the raw material to skin.
Preferably, thickener includes polyacrylate cross-linked polymer -6.
Preferably, emulsifier includes the pure and mild cetearyl glucoside of cetearyl alcohol.
The skin care item can adjust viscosity and emulsification degree is prepared into the dosage forms such as lotion, cream, frost.
Beneficial effects of the present invention:
(1) present invention contains the approximate layered liquid crystal bionic structure film of lipid between corneocyte.
Main component of the ceramide as keratoderma intercellular lipid, is that skin barrier function is played in cuticula
Critical lipid substance, the barrier function with cuticula, i.e. water tariff collection is closely related.Exogenous supplement ceramide facilitates
The perfect and recovery of impaired skin barrier function, increases the moisture holding capacity of skin itself, locks hydrone securely, reduce
Percutaneous water loss has good moisturizing and restitution, especially dry, chap skin to skin.
The present invention according to specific molar ratio, forms ceramide and cholesterol, fatty acid by liquid crystal emulsified method
Between corneocyte the Nomenclature Composition and Structure of Complexes of lipid it is close, using ceramide as principal component, with the bionical of layered liquid crystal structure
Film.It will be smeared on the skin containing the skin care item of this layered liquid crystal bionic structure film, have to skin barrier function and more rapidly show
The improvement of work, can effectively improve the water holding capacity of skin itself, and peomotes ceramide and be absorbed by the skin, and improve
The stability of ceramide in the product makes product have more stable efficient performance of keeping humidity.
(2) present invention will between corneocyte the approximate layered liquid crystal bionic structure film of lipid it is (solid with ceramide, gallbladder
Alcohol, fatty acid are main component) it is organically combined with specific skin conditioning agent, emollient, moisturizer, can be synergistic, from
Two angles of skin surface and cuticula are set out, and are promoted the promotion of skin moisturizing ability, percutaneous water loss are reduced, to realize
Superior performance of keeping humidity is effectively protected skin and improves skin condition.
Detailed description of the invention
Fig. 1 is the petrographic microscope figure of the layered liquid crystal bionic structure membrane complex of the embodiment of the present invention 1.
Fig. 2 is the performance of keeping humidity contrast test figure of the embodiment of the present invention 1 and comparative example 1.
Specific embodiment
As follows in conjunction with attached drawing, application scheme is further described:
Embodiment 1
1, a kind of Moisturizer containing layered liquid crystal bionic structure film includes following components by mass percentage:
The M68 emulsifier of the emulsifier preferred France's match BIC Corp, main component is the pure and mild spermaceti of cetearyl alcohol
Stearyl glucoside.
2, the layered liquid crystal bionic structure membrane complex includes following components by mass percentage:
| Component | Quality percentage (%) |
| Dipropylene glycol | 20 |
| Glycerol | 10 |
| 1,2- pentanediol | 5 |
| Hydrolecithin | 4.5 |
| Hydrogenated lyso lecithin | 0.1 |
| Cer NS | 1.4 |
| Isostearic acid | 0.7 |
| Cholesterol | 1.0 |
| EDETATE SODIUM | 0.1 |
| Water | 57.2 |
3, preparation method
(1) preparation of layered liquid crystal bionic structure membrane complex, comprising the following steps:
A, glycerol is added in the emulsion pot of clean dried in advance, Cer NS, different tristearin is added while homogeneous
Acid, cholesterol are heated with stirring to 95 DEG C -98 DEG C to complete melting and become transparent, no particle-liquid.
B, dipropylene glycol is heated with stirring to 80-85 DEG C, hydrolecithin is added while stirring, continue stirring 5-10 minutes
It is dissolved to uniformly without blocky light yellow clear liquid.
C, the light yellow clear liquid of step b is added in the liquid of step a emulsion pot, emulsion pot is kept for 85-90 DEG C, is stirred
It mixes 5-10 minutes, is dissolved to light yellow clear, without particle-liquid.
D, it is added water in clean kettle in advance, is heated with stirring to 85-90 DEG C, 1,2- pentanediol, EDTA is added in stirring
Disodium, hydrogenated lyso lecithin continue stirring and are uniformly dissolved for 5 minutes, keep the temperature to 85-90 DEG C.
E, homogeneous is opened, the Material filtering of step d is pumped into the emulsion pot of step c.Homogeneous 5-10 minutes is opened to system cream
Change uniform.Stirring is cooled to 40 DEG C or less.With high-pressure homogeneous when confirming bubble-free, 600bar-700bar circulation is adjusted 6 times, obtain
Layered liquid crystal bionic structure membrane complex.Its structure chart under petrographic microscope is as shown in Figure 1.
(2) preparation of the Moisturizer containing layered liquid crystal bionic structure film, comprising the following steps:
A. it takes the container of clean dried that 55-65 DEG C of water is added, adds panthenol, stirring and dissolving is standby to colourless transparent liquid
With.
B. it takes the container of clean dried that dipropylene glycol is added, is while stirring crosslinked Sodium Hyaluronate and polyacrylate poly-
It closes object -6 to be slowly added to, continues stirring after addition 5-8 minutes to uniformly without bulk, it is spare.
C. it adds water in clean emulsion pot, is heated with stirring to 90 ± 2 DEG C or so, step A and step B preparation is added
Material and glycine betaine, to being uniformly dissolved, 75 ± 1 DEG C of stirring cooling was spare in 5~8 minutes for homogeneous.
D. emulsifier, jojoba seed oil, silybin oil acetoacetic ester are added in the oil cauldron of clean dried, adjust moderate-speed mixer
Be heated to 85 ± 2 DEG C to be completely dissolved uniformly it is spare.
E. the Material filtering in step D oil cauldron is added in the emulsion pot of step C.Emulsification pot temperature is maintained at 75~80
DEG C, homogeneous 10~15 minutes are uniform to system emulsification.It is cooled to 63~68 DEG C, is added 1,2- pentanediol, homogeneous 3~5 minutes.It stirs
Mix be cooled to 45 ± 1 DEG C it is spare.
F. water, glycerol, EDETATE SODIUM are added in the container of clean dried in advance, while stirring answer layered liquid crystal structure
Conjunction object, tetrahydro methylpyrimidine carboxylic acid are slowly added to, and continue to obtain to uniformly without bulk for stirring 5~8 minutes after addition milky white
Color liquid.
G. liquid obtained in F is added in E, continues stirring and is cooled to 36~38 DEG C of inspection by sampling qualifications and filters out
Material.The dosage form of Moisturizer containing layered liquid crystal bionic structure film made from the present embodiment 1 is face cream.
Comparative example 1
A kind of basis face cream, includes following components by mass percentage:
This comparative example 1 increases ceramide, gallbladder in 1 component of dosage alternate embodiment of Sodium Hyaluronate and hyaluronic acid
Sterol, fatty acid and hydrolecithin, hydrogenated lyso lecithin are polynary with the hyaluronic acid of high moisturizing and Sodium Hyaluronate cooperation
Main moisturizing ingredient of the alcohol as basic face cream.
The preparation method of the basis face cream, the preserving moisture and protecting skin by above-described embodiment 1 containing layered liquid crystal bionic structure film
The preparation step of product operates, wherein hyaluronic acid and Sodium Hyaluronate are added in stepb together.
Performance test
With the base of Moisturizer (face cream) and comparative example 1 containing layered liquid crystal bionic structure film prepared by embodiment 1
Plinth face cream carries out performance of keeping humidity test as sample.
1, test method:
It finds and filters out skin properties as mixing, neutral or stemness, women 20 in 20~45 one full year of life of age.10
It is one group, each group of subject uses the sample of different formulations.Before test, subject needs to clean face, with dry face-cloth
Paper wiped clean, and at least 30min that sits quietly in the room of steady temperature humidity, cannot drink water, keep loosening, and use in face
The sample of one piece of unitary coin-size.
The test of skin surface moisture content is being carried out before and using rear 1h, 2h, 3h, 4h respectively.
2, test result
As shown in Fig. 2, subject is after the face cream 1h using embodiment 1, skin moisture content has apparent rising, improves
39%, after use in 4 hours, skin moisture content is kept at higher level, and skin average moisture content improves 30%, has
Good moistening effect.
And after the basic face cream 1h using comparative example 1, skin moisture content only improves 28%, after use in 4 hours, skin
Skin average moisture content only improves 20%.
The skin care item that layered liquid crystal bionic structure film is added known to comparative example 1 and comparative example 1 have excellent moisturizing
Performance, moisture of skin are obviously improved.
It is that above-mentioned preferred embodiment should be regarded as application scheme embodiment for example, all with application scheme thunder
Same, approximate or technology deduction, replacement, improvement for making based on this etc., are regarded as the protection scope of this patent.
Claims (10)
1. a kind of Moisturizer containing layered liquid crystal bionic structure film, which is characterized in that by mass percentage include following
Component: layered liquid crystal bionic structure membrane complex 1-10%, skin conditioning agent 1-10%, emollient 5-15%, Sodium Hyaluronate
0.01-0.05%, glycine betaine 1-3%, polyalcohol 8-27%, thickener 0.1-0.8%, chelating agent 0.05-0.1%, emulsifier
0.5-2% and water 35%-70%；
The layered bionical membrane complex of liquid crystal structure includes: ceramide, the cholesterol of 0.1-10% by its mass percent
With fatty acid mixt, the liquid crystal emulsifier of 0.1-5%, the polyalcohol of 10-60%, chelating agent 0.05-0.1%, excess water, respectively
The sum of component is 100%；
In the ceramide, cholesterol and fatty acid mixt, ceramide, cholesterol, fatty acid molar ratio be 1:
1:1~3:1:1.
2. the Moisturizer according to claim 1 containing layered liquid crystal bionic structure film, which is characterized in that the mind
Through amide include one of Cer EOS, Cer NS, Cer NP, Cer AP II, two or more.
3. the Moisturizer according to claim 1 containing layered liquid crystal bionic structure film, which is characterized in that the liquid
Brilliant emulsifier includes hydrolecithin and hydrogenated lyso lecithin.
4. the Moisturizer according to claim 1 containing layered liquid crystal bionic structure film, which is characterized in that the rouge
Fat acid include one of palmitinic acid, stearic acid, isostearic acid, behenic acid, two or more.
5. the Moisturizer according to claim 1 containing layered liquid crystal bionic structure film, which is characterized in that polyalcohol
Including a variety of in glycerol, dipropylene glycol, 1,3 butylene glycol, isoprene.
6. the Moisturizer according to claim 1 containing layered liquid crystal bionic structure film, which is characterized in that the skin
Skin conditioner includes panthenol, tetrahydro methylpyrimidine carboxylic acid, two or more in glycosphingolipids.
7. the Moisturizer according to claim 1 containing layered liquid crystal bionic structure film, which is characterized in that the profit
Skin agent includes one of jojoba seed oil, silybin oil acetoacetic ester, phytosterols oletate and tocopherol, two kinds or more
Kind.
8. the Moisturizer according to claim 1 containing layered liquid crystal bionic structure film, which is characterized in that thickener
Including polyacrylate cross-linked polymer -6.
9. the Moisturizer according to claim 1 containing layered liquid crystal bionic structure film, which is characterized in that emulsifier
Including the pure and mild cetearyl glucoside of cetearyl alcohol.
10. the Moisturizer according to claim 1 containing layered liquid crystal bionic structure film, which is characterized in that chelating
Agent includes EDETATE SODIUM.
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111110589A (en) * | 2019-12-12 | 2020-05-08 | 广东博然堂生物科技有限公司 | Long-acting moisturizing composition and skin care product thereof |
| CN111135107A (en) * | 2020-01-09 | 2020-05-12 | 广州市科能化妆品科研有限公司 | Composition for repairing skin barrier and preparation method thereof |
| CN111467284A (en) * | 2020-04-29 | 2020-07-31 | 泉后(广州)生物科技研究院有限公司 | Anti-aging nano composition and preparation method and application thereof |
| CN111568829A (en) * | 2020-06-03 | 2020-08-25 | 上海新高姿化妆品有限公司 | High-content ceramide repair cream and preparation method thereof |
| CN111920741A (en) * | 2020-09-08 | 2020-11-13 | 张晶 | A skin caring composition and method |
| CN112245315A (en) * | 2020-10-14 | 2021-01-22 | 广州环亚化妆品科技有限公司 | Ceramide facial mask with moisturizing and repairing effects and preparation method thereof |
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| CN115120532A (en) * | 2022-08-19 | 2022-09-30 | 厦门海马化妆品有限公司 | Skin-care cream and preparation method thereof |
| CN115737484A (en) * | 2022-11-21 | 2023-03-07 | 媞颂日化用品(广州)有限公司 | Bionic hair care composition with repairing effect and application thereof |
| CN115737502A (en) * | 2022-11-25 | 2023-03-07 | 上海传美实业有限公司 | BMR bionic repair co-delivery system and preparation method and application thereof |
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Application publication date: 20191008 |