CN111135107A - Composition for repairing skin barrier and preparation method thereof - Google Patents
Composition for repairing skin barrier and preparation method thereof Download PDFInfo
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- CN111135107A CN111135107A CN202010021396.3A CN202010021396A CN111135107A CN 111135107 A CN111135107 A CN 111135107A CN 202010021396 A CN202010021396 A CN 202010021396A CN 111135107 A CN111135107 A CN 111135107A
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- ceramide
- acid
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- skin
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- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 230000008591 skin barrier function Effects 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title description 8
- 150000002632 lipids Chemical class 0.000 claims abstract description 25
- 238000003756 stirring Methods 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 230000001804 emulsifying effect Effects 0.000 claims description 16
- 229940106189 ceramide Drugs 0.000 claims description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 8
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 7
- 239000000194 fatty acid Substances 0.000 claims description 7
- 229930195729 fatty acid Natural products 0.000 claims description 7
- 150000004665 fatty acids Chemical class 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 6
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 6
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 6
- 239000004264 Petrolatum Substances 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 229940075529 glyceryl stearate Drugs 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 6
- 229940066842 petrolatum Drugs 0.000 claims description 6
- 235000019271 petrolatum Nutrition 0.000 claims description 6
- 229960005323 phenoxyethanol Drugs 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 5
- 235000021355 Stearic acid Nutrition 0.000 claims description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
- 239000008117 stearic acid Substances 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 4
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 239000005639 Lauric acid Substances 0.000 claims description 4
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 229960001631 carbomer Drugs 0.000 claims description 4
- -1 ceramide 2 Chemical compound 0.000 claims description 4
- 229940099417 ceramide 2 Drugs 0.000 claims description 4
- 229940095137 ceramide 6 ii Drugs 0.000 claims description 4
- 229960003993 chlorphenesin Drugs 0.000 claims description 4
- 235000012000 cholesterol Nutrition 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims description 4
- 238000004945 emulsification Methods 0.000 claims description 4
- 229930182478 glucoside Natural products 0.000 claims description 4
- 150000008131 glucosides Chemical class 0.000 claims description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- 239000002480 mineral oil Substances 0.000 claims description 4
- 235000010446 mineral oil Nutrition 0.000 claims description 4
- 229920005862 polyol Polymers 0.000 claims description 4
- 150000003077 polyols Chemical class 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 3
- 229940035437 1,3-propanediol Drugs 0.000 claims description 3
- 239000000686 essence Substances 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 3
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims description 2
- 241001530056 Athelia rolfsii Species 0.000 claims description 2
- 235000021357 Behenic acid Nutrition 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 235000021360 Myristic acid Nutrition 0.000 claims description 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 2
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 2
- 235000021314 Palmitic acid Nutrition 0.000 claims description 2
- NENOAJSZZPODGJ-OIMNJJJWSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] octanoate Chemical compound CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NENOAJSZZPODGJ-OIMNJJJWSA-N 0.000 claims description 2
- RBBHGNBWKGCPAF-XEKXCHJCSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC RBBHGNBWKGCPAF-XEKXCHJCSA-N 0.000 claims description 2
- MIUIRGGKIICMBP-NFOZDHADSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC MIUIRGGKIICMBP-NFOZDHADSA-N 0.000 claims description 2
- DRRMRHKHTQRWMB-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(COC(=O)C(CC)CCCC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DRRMRHKHTQRWMB-UHFFFAOYSA-N 0.000 claims description 2
- ZGBFGAHZKZQSLG-UMCOJZBLSA-N [30-oxo-30-[[(e,2s,3r,6r)-1,3,6-trihydroxyoctadec-4-en-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCC[C@@H](O)\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC ZGBFGAHZKZQSLG-UMCOJZBLSA-N 0.000 claims description 2
- 229940116226 behenic acid Drugs 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 2
- 229940048864 ceramide 1 Drugs 0.000 claims description 2
- 229940044176 ceramide 3 Drugs 0.000 claims description 2
- 150000001783 ceramides Chemical class 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 235000012209 glucono delta-lactone Nutrition 0.000 claims description 2
- 229960003681 gluconolactone Drugs 0.000 claims description 2
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 19
- 230000008439 repair process Effects 0.000 abstract description 8
- 239000002537 cosmetic Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract 1
- 210000002615 epidermis Anatomy 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 18
- 238000006243 chemical reaction Methods 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- 206010015150 Erythema Diseases 0.000 description 6
- 231100000321 erythema Toxicity 0.000 description 6
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 3
- 206010040914 Skin reaction Diseases 0.000 description 3
- 230000008595 infiltration Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000037307 sensitive skin Effects 0.000 description 3
- 230000035483 skin reaction Effects 0.000 description 3
- 231100000430 skin reaction Toxicity 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 206010033733 Papule Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 238000007705 chemical test Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000000799 fusogenic effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to a composition for repairing a skin barrier. The skin barrier repair composition of the present invention includes a physiological lipid and a non-physiological lipid. The repair effect of the skin barrier is effectively accelerated by compounding the physiological lipid and the non-physiological lipid, so that the skin barrier function is improved, and the moisture loss of the epidermis is prevented. The skin is recovered to be healthy.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a composition for repairing a skin barrier and a preparation method thereof.
Background
In recent years, more and more people damage skin barriers due to over-cleaning and the like, the stratum corneum in the skin plays a role in protecting the human body from the external environment, lipid is an important component of the lipid barrier built in the stratum corneum like bricks, and once the skin barrier is damaged, the moisture retention capacity of the skin is reduced, so that the symptoms of tight, dry, peeling, erythema and the like after washing are caused, and even sensitive skin is easily generated.
The existing commercial skin barrier repair products mostly use non-physiological lipid with strong blocking property in oil selection, and the effect is poorer than that of using physiological lipid with proper proportion.
Disclosure of Invention
The present invention provides a composition for repairing a skin barrier.
The invention also provides application of the skin barrier repairing composition in preparation of cream, lotion, essence and mask products.
The invention also provides a preparation method of the composition for repairing the skin barrier.
The invention provides a composition for repairing skin barrier, which is beneficial to accelerating the repair of the skin barrier through reasonable proportioning of non-physiological lipid and is suitable for sensitive skin.
In one embodiment, there is provided a skin barrier repair composition comprising, in weight percent: 1-10% of physiological lipid and 1-30% of non-physiological lipid.
In a preferred embodiment, the following components are contained in weight percent: 2-8% of physiological lipid and 5-20% of non-physiological lipid.
In one embodiment, the physiological lipid is selected from the group consisting of fatty acids, cholesterol, ceramides; preferably, the weight percentage of the fatty acid, the cholesterol and the ceramide is 2:1:1-3:1: 1.
In one embodiment, the fatty acid is selected from one or more of lauric acid, palmitic acid, stearic acid, behenic acid, myristic acid; preferably one or more of lauric acid and stearic acid; stearic acid is more preferred.
In one embodiment, the ceramide is selected from one or more of ceramide 1, ceramide 1A, ceramide 2, ceramide 3, ceramide 4, ceramide 6 II.
In one embodiment, the ceramide is selected from one or more of ceramide 2, ceramide 6 II.
In one embodiment, the non-physiological lipid is a combination of one or more of petrolatum, white mineral oil, hydrogenated polydecene, pentaerythritol tetrakis (ethyl hexanoate), cetyl ethyl hexanoate, polydimethylsiloxane; preferably one or more of petrolatum, white mineral oil, hydrogenated polydecene; more preferably petrolatum.
In one embodiment, there is also provided a skin barrier repair composition further comprising in weight percent: 1-15% of polyol; preferably 3 to 8%; 0.2 to 1 percent of preservative; preferably 0.3 to 0.6; 1-5% of emulsifier; preferably 2 to 3%; 0.2 to 2 percent of thickening agent; preferably 0.3 to 1%; the balance of deionized water.
In one embodiment, there is also provided a composition for repairing a skin barrier, the polyol selected from the group consisting of glycerol, propylene glycol, 1, 3-propanediol, 1, 3-butanediol, dipropylene glycol, sorbitol, diglycerol, and combinations of one or more thereof; preferably one or more of glycerol, 1, 3-propylene glycol and sorbitol; more preferably glycerol.
In one embodiment, there is also provided a skin barrier repair composition, the preservative being selected from the group consisting of one or more of p-hydroxyacetophenone, phenoxyethanol, chlorphenesin, methylparaben, sorbitan caprylate, benzoic acid, gluconolactone, sodium benzoate; preferably one or more of phenoxyethanol and chlorphenesin; more preferably phenoxyethanol.
In one embodiment, there is also provided a composition for repairing a skin barrier, the emulsifier selected from the group consisting of PEG-100 glyceryl stearate, cetearyl glucoside, hydrogenated lecithin, ceteareth-25 in combination with one or more; preferably one or more of PEG-100 glyceryl stearate, cetearyl glucoside, hydrogenated lecithin; more preferably PEG-100 glyceryl stearate.
In one embodiment, there is also provided a composition for repairing a skin barrier, the thickening agent selected from the group consisting of one or more of hydroxyethylcellulose, carbomer, xanthan gum, sclerotium rolfsii gum in combination; preferably one or more of carbomer and xanthan gum; more preferably xanthan gum.
In one embodiment, there is also provided the use of the composition in the preparation of a skin care product; preferably, the types of the skin care products comprise one or more of lotion, cream, essence and mask.
In one embodiment, there is also provided a method of preparing a composition for repairing a skin barrier, comprising the steps of:
(1) preparing raw materials according to the composition;
(2) adding water, polyalcohol and thickener into an emulsifying pot, stirring for dissolving, heating to 85-95 deg.C, and maintaining the temperature for 10-20 min; preferably, heating to 90 ℃; preferably, the incubation is for 15 minutes;
(3) putting physiological lipid, non-physiological lipid and an emulsifier into an emulsifying pot, and stirring, dissolving and dispersing uniformly at the temperature of 80-90 ℃; emulsifying at a homogenizing rotation speed of 1000-3000 rpm for 1-5 minutes, stirring at a rotation speed of 20-30 rpm for 5 minutes after emulsification, and cooling
(4) When the temperature is reduced to 40-45 ℃, adding a preservative into the emulsifying pot, and uniformly stirring;
(5) vacuumizing, stirring uniformly, cooling to 30-40 ℃, and discharging; preferably, the temperature is reduced to 35 ℃.
The invention has the following beneficial effects:
(1) the skin barrier is efficiently repaired, and the skin barrier is suitable for sensitive skin.
(2) The stability is good: the compositions of the present invention exhibit good stability, whether at room temperature, high temperature, low temperature, or in a cyclic temperature system.
Detailed Description
The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others of the concepts fall within the scope of the invention.
Examples 1-5 compositions containing different Components
TABLE 1 examples of the different components (unit: wt%)
The preparation method comprises the following steps:
(1) adding the phase A into an emulsifying pot, stirring and dissolving, heating to 90 ℃, and preserving heat for 15 minutes.
(2) Putting the phase B into an emulsifying pot, and stirring, dissolving and dispersing uniformly at the temperature of 80-90 ℃; emulsifying at a homogenizing rotation speed of 1000-3000 rpm for 1-5 minutes, and stirring at a rotation speed of 20-30 rpm for 5 minutes after emulsification to start cooling.
(3) When the temperature is reduced to 40-45 ℃, adding a preservative into the emulsifying pot, and uniformly stirring;
(4) vacuumizing, stirring, cooling to 35 deg.C, and discharging.
Comparative examples 1-4 compositions containing different Components
TABLE 2 comparative examples of different components (unit: wt%)
TABLE 3 comparative examples of the different components (unit: wt%)
The preparation method comprises the following steps:
(1) adding the phase A into an emulsifying pot, stirring and dissolving, heating to 90 ℃, and preserving heat for 15 minutes.
(2) Putting the phase B into an emulsifying pot, and stirring, dissolving and dispersing uniformly at the temperature of 80-90 ℃; emulsifying at a homogenizing rotation speed of 1000-3000 rpm for 1-5 minutes, and stirring at a rotation speed of 20-30 rpm for 5 minutes after emulsification to start cooling.
(3) When the temperature is reduced to 40-45 ℃, adding a preservative into the emulsifying pot, and uniformly stirring;
(4) vacuumizing, stirring, cooling to 35 deg.C, and discharging.
Physical and chemical tests:
the results of the physicochemical tests conducted on examples 1 to 5 and comparative examples 1 to 9 were as follows:
appearance: the white color is milky, and the white color is milky,
pH value: 6-8.
Comparison of stability of examples and comparative examples
To examine the stability of the composition of the present invention, 120g of the compositions of examples 1 to 5 and comparative examples 1 to 9 were taken and placed in a room temperature, a incubator at 48 deg.C, a refrigerator at-20 deg.C and a circulation oven at-20-25-48 deg.C, respectively, and then the stability was observed for 1 month. The observation results are shown in table 4 below.
Table 4 stability test results
As can be seen from the results in Table 3 above, examples 1 to 5 of the present invention and comparative examples 1 to 9 showed good dosage form stability.
Patch test
1. Experimental methods
1.1 test materials
The test substance: compositions of examples 1-5, compositions of comparative examples 1-9.
A spot tester: shanghai sanitation Material works, Ltd. + 140801;
testing an instrument: a quantitative piston gun (Microman M100+ GILSON LCO5239), a single channel pipette (Transferpette +08N 33275).
2. Test method
Subject: a total of 30 subjects; minimum age 23 years, maximum age 35 years; average age 27 ± 5.1 year old volunteers met the enrollment criteria.
The spot-sticking test method comprises the following steps: selecting a qualified spot tester, placing 0.020-0.025g of a tested object in the spot tester by a closed spot test method, externally applying a medical adhesive tape to the back of the tested object, removing the tested object after 24 hours, observing skin reactions 0.5, 24 and 48 hours after the spot is removed, and recording the results according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).
3. Basis of examination
The fifth part of the human skin closed patch test skin adverse reaction grading standard of the technical Specification for cosmetic safety (2015 edition) shows the detection results as shown in Table 3.
The specific reaction degree grading grade is as follows:
0 negative reaction;
1 suspicious reaction: only faint erythema;
2 weak positive reaction (erythema reaction): erythema, infiltration, edema, and possibly papules;
strong positive reaction (herpes reaction): erythema, infiltration, edema, papules, herpes: the reaction may be beyond the test area;
4 very strong positive reaction (fusogenic herpes reaction): obvious erythema, severe infiltration, edema, fusional herpes: the reaction goes beyond the test area.
TABLE 5 results of the human skin occlusive patch test for the compositions of examples 1-5
From the above conclusion of table 5 it can be seen that: the result of the human skin closed patch test shows that 0 of 30 persons has positive reaction, and the test object does not cause adverse skin reaction to the batch of test objects according to the regulation in technical Specification for cosmetic safety (2015 edition). The results show that examples 1-5 of the present invention, comparative examples 1-9, are non-irritating to the skin and have no positive response.
Efficacy test
The principle of moisture measurement by means of the Corneometer CM825, a german CK skin moisture tester, is based on the fact that the dielectric constant (<7) of water and other substances varies considerably, and that, depending on the moisture content, a suitably shaped measuring capacitor changes with the change in the capacitance of the skin, which is within the measurement range, so that the moisture content of the skin can be measured. The degree of repair of the skin barrier is indirectly obtained through the moisture content.
The main technical parameters are as follows:
1. the test principle is as follows: the capacitive principle;
2. area of the test head: 7 x 7mm2；
3. And (3) probe parameters: a length of about 11 cm;
4. measurement time frequency: 0.9-1.2 MHZ;
5. and (3) testing pressure: 1.1-1.5N;
6. precision: plus or minus 3 percent;
7. numerical ranges: 0 to 130;
8. weight: about 41 g.
Using a german CK skin moisture tester, Corneometer CM825, 15 volunteers were given a face wash before use, and then 15 volunteers were given the above-described compositions of examples 1 to 5 and comparative examples 1 to 9 and a commercial moisturizing cream in an amount of 0.5 g, and the skin moisture content of each subject was measured under conditions of constant temperature and constant humidity (21 ℃ and 40% humidity) using a skin moisture tester, and as a reference value, T0 immediately after application and changes in the skin moisture content 2 hours (T2), 4 hours (T4) and 8 hours (T8) after application were measured, and the test results are shown in table 6.
Skin water loss △ M value
△M＝T0-T8
△ M has a lower value and less water loss, indicating better skin barrier function.
TABLE 6
As can be seen from the test results of Table 6, in the case of using examples 1 to 5, the skin moisture content decreased less than that of comparative examples 1 to 9 and a commercial moisturizing milk within 8 hours after the use. The change in moisture content may reflect the skin barrier function, with more complete skin barrier function and less transepidermal water loss, indicating an improved skin barrier with the compositions of the present invention.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents and are included in the scope of the present invention.
Claims (10)
1. A composition for repairing a skin barrier, comprising in weight percent: 1-10% of physiological lipid and 1-30% of non-physiological lipid;
preferably, physiological lipids 2-8%;
preferably, the non-physiological lipid is 5-20%.
2. The composition of claim 1, wherein the physiological lipid is selected from the group consisting of fatty acids, cholesterol, ceramides; preferably, the weight percentage of the fatty acid, the cholesterol and the ceramide is 2:1:1-3:1: 1;
preferably, the fatty acid is selected from one or more of lauric acid, palmitic acid, stearic acid, behenic acid and myristic acid;
further preferably, the fatty acid is selected from one or more of lauric acid, stearic acid;
preferably, the ceramide is selected from one or more of ceramide 1, ceramide 1A, ceramide 2, ceramide 3, ceramide 4, ceramide 6 II;
further preferably, the ceramide is selected from one or more of ceramide 2 and ceramide 6 II.
3. The composition of claim 1, wherein the non-physiological lipid is selected from the group consisting of petrolatum, white mineral oil, hydrogenated polydecene, pentaerythritol tetra (ethyl hexanoate), cetyl ethyl hexanoate, and a combination of one or more of polydimethylsiloxane; preferably selected from one or more of petrolatum, white mineral oil, hydrogenated polydecene; more preferably petrolatum.
4. The composition of claim 1, further comprising in weight percent:
1-15% of polyol; preferably 3 to 8%;
0.2 to 1 percent of preservative; preferably 0.3-0.6%;
1-5% of emulsifier; preferably 2 to 3%;
0.2 to 2 percent of thickening agent; preferably 0.3 to 1%;
the balance of deionized water.
5. The composition of claim 4, wherein the polyol is selected from the group consisting of glycerol, propylene glycol, 1, 3-propanediol, 1, 3-butanediol, dipropylene glycol, sorbitol, diglycerol; preferably selected from one or more of glycerol, 1, 3-propanediol, sorbitol; more preferably glycerol.
6. The composition of claim 4, wherein the preservative is selected from the group consisting of one or more of p-hydroxyacetophenone, phenoxyethanol, chlorphenesin, methylparaben, sorbitan caprylate, benzoic acid, gluconolactone, sodium benzoate; preferably one or more of phenoxyethanol and chlorphenesin; more preferably phenoxyethanol.
7. The composition of claim 4, wherein the emulsifier is selected from the group consisting of PEG-100 glyceryl stearate, cetearyl glucoside, hydrogenated lecithin, ceteareth-25 in combination with one or more; preferably a combination of one or more selected from PEG-100 glyceryl stearate, cetearyl glucoside, hydrogenated lecithin; more preferably PEG-100 glyceryl stearate.
8. The composition of claim 4, wherein the thickener is selected from the group consisting of one or more of hydroxyethylcellulose, carbomer, xanthan gum, sclerotium rolfsii gum; preferably one or more selected from carbomer, xanthan gum; more preferably xanthan gum.
9. Use of a composition according to any one of claims 1 to 8 in the manufacture of a skin care product; preferably, the types of the skin care products comprise one or more of lotion, cream, essence and mask.
10. A method of preparing the composition of claim 4, comprising the steps of:
(1) preparing raw materials according to the composition;
(2) adding water, polyalcohol and thickener into an emulsifying pot, stirring for dissolving, heating to 85-95 deg.C, and maintaining the temperature for 10-20 min; preferably, heating to 90 ℃; preferably, the incubation is for 15 minutes;
(3) putting physiological lipid, non-physiological lipid and an emulsifier into an emulsifying pot, and stirring, dissolving and dispersing uniformly at the temperature of 80-90 ℃; emulsifying at a homogenizing rotating speed of 1000-3000 rpm for 1-5 minutes, and stirring at a rotating speed of 20-30 rpm for 5 minutes after emulsification to start cooling;
(4) when the temperature is reduced to 40-45 ℃, adding a preservative into the emulsifying pot, and uniformly stirring;
(5) vacuumizing, stirring uniformly, cooling to 30-40 ℃, and discharging; preferably, the temperature is reduced to 35 ℃.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737502A (en) * | 2022-11-25 | 2023-03-07 | 上海传美实业有限公司 | BMR bionic repair co-delivery system and preparation method and application thereof |
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| CN109010205A (en) * | 2018-08-29 | 2018-12-18 | 广州四环康源化妆品有限公司 | A kind of sensitivity flesh remediation composition and preparation method thereof |
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| CN110302063A (en) * | 2019-07-05 | 2019-10-08 | 中山中研化妆品有限公司 | A kind of Moisturizer containing layered liquid crystal bionic structure film |
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| CN104173207A (en) * | 2014-08-11 | 2014-12-03 | 上海贝泰妮生物科技有限公司 | Skin barrier repairing preparation and preparation method thereof |
| CN109010205A (en) * | 2018-08-29 | 2018-12-18 | 广州四环康源化妆品有限公司 | A kind of sensitivity flesh remediation composition and preparation method thereof |
| CN109464296A (en) * | 2018-11-19 | 2019-03-15 | 拉芳家化股份有限公司 | A kind of reparation cream of the triacetate containing resveratrol |
| CN110302063A (en) * | 2019-07-05 | 2019-10-08 | 中山中研化妆品有限公司 | A kind of Moisturizer containing layered liquid crystal bionic structure film |
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| CN115737502A (en) * | 2022-11-25 | 2023-03-07 | 上海传美实业有限公司 | BMR bionic repair co-delivery system and preparation method and application thereof |
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